Investor Opaleye Management Inc.
13D/G Filings

This page shows a list of all the recent 13D/G filings made by Opaleye Management Inc. . Schedule 13D is commonly referred to as a “beneficial ownership report.” The term "beneficial owner" is defined under SEC rules. It includes any person who directly or indirectly shares voting power or investment power (the power to sell the security).

When a person or group of persons acquires beneficial ownership of more than 5% of a voting class of a company’s equity securities, they are required to file a Schedule 13D within ten days after the purchase. Click the link icon to see the full transaction history.

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Date Form Target Prev
Shares		 Current
Shares		 Change
(Percent)		 Ownership
(Percent)		 Change
(Percent)
2025-08-29 13G LRMR / Larimar Therapeutics, Inc. 3,952,409 4,110,000
2025-08-29 13G SLGL / Sol-Gel Technologies Ltd. 139,386
2025-04-28 13G/A TARA / Protara Therapeutics, Inc. 1,825,000 1,730,000
2025-04-16 13G LRMR / Larimar Therapeutics, Inc. 1,560,000 3,952,409
2025-02-14 13G/A OCUL / Ocular Therapeutix, Inc. 6,070,000 4,342,500
2025-02-14 13G/A IBIO / iBio, Inc. 650,000 750,000
2025-02-14 13G/A TARA / Protara Therapeutics, Inc. 1,681,154 1,825,000
2025-02-14 13G/A CNTX / Context Therapeutics Inc. 820,000 0
2024-11-18 13G TARA / Protara Therapeutics, Inc. 2,508,472 1,681,154
2024-10-22 13G/A SNWV / SANUWAVE Health, Inc. 944,132
2024-09-18 13G/A CDXS / Codexis, Inc. 3,540,000 7,524,000
2024-09-12 13G/A ETON / Eton Pharmaceuticals, Inc. 2,524,887 2,672,500
2024-07-12 13G CDXS / Codexis, Inc. 3,540,000
2024-04-09 13G/A IBIO / iBio, Inc. 650,000 650,000
2024-04-08 13G IBIO / iBio, Inc. 650,000
2024-02-14 13G/A OCUL / Ocular Therapeutix, Inc. 6,075,000 6,070,000
2024-02-14 13G/A SNWV / SANUWAVE Health, Inc. 31,428,571 115,493,554
2024-02-09 13G/A ETON / Eton Pharmaceuticals, Inc. 2,170,000 2,524,887
2024-02-09 13D/A TCON / TRACON Pharmaceuticals, Inc. 0
2024-02-09 13G/A HROW / Harrow, Inc. 3,775,000 3,820,000
2024-02-09 13G JNCE / Jounce Therapeutics Inc 2,810,000 0
2024-01-05 13G CNTX / Context Therapeutics Inc. 820,000
2023-04-12 13G JNCE / Jounce Therapeutics Inc 2,810,000
2023-02-13 13G/A SNWV / SANUWAVE Health, Inc. 31,428,571 31,428,571
2023-02-13 13G/A CMRX / Chimerix, Inc. 5,580,000 0
2023-02-13 13G/A OCUL / Ocular Therapeutix, Inc. 5,974,800 6,075,000
2023-01-23 13G/A LRMR / Larimar Therapeutics, Inc. 943,702 1,560,000
2023-01-20 13G/A HROW / Harrow, Inc. 3,285,000 3,775,000
2023-01-20 13G/A ETON / Eton Pharmaceuticals, Inc. 2,385,000 2,170,000
2022-06-10 13D TELA / TELA Bio, Inc. 751,168 1,557,500
2022-06-03 13G TELA / TELA Bio, Inc. 751,168
2022-02-18 13G LRMR / Larimar Therapeutics, Inc. 943,702
2022-02-01 13G/A CMRX / Chimerix, Inc. 5,580,000
2022-02-01 13G/A OCUL / Ocular Therapeutix, Inc. 5,974,800
2022-02-01 13G/A GMTX / Gemini Therapeutics Inc 0
2022-01-26 13G/A SNWV / SANUWAVE Health, Inc. 31,428,571
2022-01-26 13G/A ADMS / Adamas Pharmaceuticals Inc 0
2022-01-26 13G/A HROW / Harrow, Inc. 3,285,000
2022-01-24 13G/A ETON / Eton Pharmaceuticals, Inc. 2,385,000
2021-06-17 13G/A ETON / Eton Pharmaceuticals, Inc.
2021-02-12 13G/A OCUL / Ocular Therapeutix, Inc.
2021-02-12 13G/A EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
2021-02-12 13G/A SNWV / SANUWAVE Health, Inc.
2021-02-12 13G/A CMRX / Chimerix, Inc.
2021-02-12 13G/A INFI / Infinity Pharmaceuticals Inc.
2021-02-12 13G/A ADMS / Adamas Pharmaceuticals Inc
2021-02-12 13G/A CRDF / Cardiff Oncology, Inc.
2021-02-12 13G/A SMLR / Semler Scientific, Inc.
2021-02-12 13G/A STXS / Stereotaxis, Inc.
2021-02-12 13G/A HROW / Harrow, Inc.
2021-02-12 13G/A FBIO / Fortress Biotech, Inc.
2021-02-12 13G/A TCON / TRACON Pharmaceuticals, Inc. 1,718,346
2021-02-12 13G/A / FS Development Corp. Class A
2021-02-12 13G/A ATXI / Avenue Therapeutics, Inc.
2021-01-08 13G / FS Development Corp. Class A
2020-09-25 13D/A TARA / Protara Therapeutics, Inc. 5,036,010 2,508,472
2020-09-21 13G INFI / Infinity Pharmaceuticals Inc.
2020-09-18 13G INFI / Infinity Pharmaceuticals Inc.
2020-09-01 13G TCON / TRACON Pharmaceuticals, Inc. 1,718,346
2020-08-28 13G CRDF / Cardiff Oncology, Inc.
2020-08-21 13G ADMS / Adamas Pharmaceuticals Inc
2020-08-21 13G CMRX / Chimerix, Inc.
2020-05-26 13G/A ETON / Eton Pharmaceuticals, Inc.
2020-04-07 13G/A ETON / Eton Pharmaceuticals, Inc.
2020-04-06 13G/A ETON / Eton Pharmaceuticals, Inc.
2020-03-30 13G SMLR / Semler Scientific, Inc.
2020-02-21 13G CDTX / Cidara Therapeutics, Inc.
2020-02-14 13G/A CDTX / Cidara Therapeutics, Inc.
2020-02-14 13G/A FBIO / Fortress Biotech, Inc.
2020-02-14 13G/A ATXI / Avenue Therapeutics, Inc.
2020-02-14 13G/A AVTX / Avalo Therapeutics, Inc.
2020-02-14 13G/A ETON / Eton Pharmaceuticals, Inc.
2020-02-14 13G/A EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
2020-02-14 13G/A STXS / Stereotaxis, Inc.
2020-01-27 13D/A TARA / Protara Therapeutics, Inc. 5,036,010 5,036,010
2020-01-21 13G SNWV / SANUWAVE Health, Inc.
2020-01-21 13D TARA / Protara Therapeutics, Inc. 5,036,010
2020-01-10 13G/A OCUL / Ocular Therapeutix, Inc.
2019-12-27 13G APTO / Aptose Biosciences Inc.
2019-11-22 13G FBIO / Fortress Biotech, Inc.
2019-11-07 13G EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
2019-08-16 13G STXS / Stereotaxis, Inc.
2019-05-24 13G ETON / Eton Pharmaceuticals, Inc.
2019-05-03 13G OCUL / Ocular Therapeutix, Inc.
2019-02-14 13G/A AVTX / Avalo Therapeutics, Inc.
2019-02-14 13G/A HROW / Harrow, Inc.
2019-02-14 13G/A FENC / Fennec Pharmaceuticals Inc.
2019-02-14 13G/A AXGN / Axogen, Inc.
2019-02-14 13G/A RCKT / Rocket Pharmaceuticals, Inc.
2019-02-14 13G/A CDTX / Cidara Therapeutics, Inc.
2019-02-14 13G/A SBBP / Strongbridge Biopharma plc
2019-01-22 13G ATXI / Avenue Therapeutics, Inc.
2018-10-03 13G AVTX / Avalo Therapeutics, Inc.
2018-09-07 13G HROW / Harrow, Inc.
2018-06-22 13G FENC / Fennec Pharmaceuticals Inc.
2018-06-22 13G SBBP / Strongbridge Biopharma plc
2018-06-04 13G CDTX / Cidara Therapeutics, Inc.
2018-02-09 13G/A SYBX / Synlogic, Inc.
2018-02-09 13G/A TNXP / Tonix Pharmaceuticals Holding Corp.
2018-02-09 13G AXGN / Axogen, Inc.
2018-02-09 13G/A RCKT / Rocket Pharmaceuticals, Inc.
2017-10-06 13G RCKT / Rocket Pharmaceuticals, Inc.
2017-06-29 13G SYBX / Synlogic, Inc.
2017-04-17 13G TNXP / Tonix Pharmaceuticals Holding Corp.
2017-02-23 13G/A HROW / Harrow, Inc.
2017-02-23 13G/A GNMX / Aevi Genomic Medicine, Inc.
2017-02-23 13G/A AXGN / Axogen, Inc.
2017-02-23 13G/A HROW / Harrow, Inc.
2017-02-23 13G/A IL0011177958 / Intec Pharma Ltd
2017-02-23 13G/A PLX / Protalix BioTherapeutics, Inc.
2017-02-23 13G/A WGBS / WaferGen Bio-Systems, Inc.
2016-11-28 13G WGBS / WaferGen Bio-Systems, Inc.
2016-04-21 13G GNMX / Aevi Genomic Medicine, Inc.
2016-04-21 13G GNMX / Aevi Genomic Medicine, Inc.
2016-02-12 13G/A HROW / Harrow, Inc.
2016-02-12 13G/A IL0011177958 / Intec Pharma Ltd
2016-02-12 13G/A HROW / Harrow, Inc.
2016-02-12 13G/A TRIL / Trillium Therapeutics Inc
2016-02-12 13G/A PLX / Protalix BioTherapeutics, Inc.
2015-11-23 13G PLX / Protalix BioTherapeutics, Inc.
2015-08-14 13G IL0011177958 / Intec Pharma Ltd
2015-05-20 13G/A HROW / Harrow, Inc.
2015-05-20 13G/A HROW / Harrow, Inc.
2015-02-23 13G TRIL / Trillium Therapeutics Inc
2015-02-13 13G/A NSPR / InspireMD, Inc.
2015-02-13 13G/A HROW / Harrow, Inc.
2015-02-13 13G/A REPH / Societal CDMO Inc
2014-09-05 13G HROW / Harrow, Inc.
2014-07-24 13G REPH / Societal CDMO Inc
2014-02-07 13G/A OCRX / Ocera Therapeutics, Inc.
2014-01-16 13G NSPR / InspireMD, Inc.