Market Value1,538,677,000
Total Holdings194
File Date2013-11-14
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price		 Prev
Shares		 Current
Shares		 Change
(Percent)		 Prev Value
(USD x1000)		 Current Value
(USD x1000)		 Change
(Percent)
ALBO / Albireo Pharma Inc Put
ALBO / Albireo Pharma Inc Call
ABIO / ARCA biopharma, Inc.
AASTROM BIOSCIENCES INC / (00253U305)
ABBV / AbbVie Inc.
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
ACAD / ACADIA Pharmaceuticals Inc.
ACAD / ACADIA Pharmaceuticals Inc.
ACAD / ACADIA Pharmaceuticals Inc.
ARAY / Accuray Incorporated
ARAY / Accuray Incorporated
ARAY / Accuray Incorporated
ACRX / Talphera, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc.
ACOR / Acorda Therapeutics, Inc.
AEGR / Aegerion Pharmaceuticals, Inc.
AEGR / Aegerion Pharmaceuticals, Inc.
AEGR / Aegerion Pharmaceuticals, Inc.
AGEN / Agenus Inc.
AGEN / Agenus Inc.
NWBO / Northwest Biotherapeutics, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc.
ALXA / Alexza Pharmaceuticals, Inc.
ALGN / Align Technology, Inc. Call
018490100 / Allergan plc
018490100 / Allergan plc
ALNY / Alnylam Pharmaceuticals, Inc. Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
CYTR / LadRx Corp
ANTH / Anthera Pharmaceuticals, Inc.
ARNA / Arena Pharmaceuticals Inc
ARNA / Arena Pharmaceuticals Inc
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARROWHEAD RESEARCH CORP / (042797209)
ARROWHEAD RESEARCH CORP / (042797909)
ASTX / Investment Managers Series Trust II - Tradr 2X Long ASTS Daily ETF
ASTEX / American Funds Short-Term Tax-Exempt Bond Fund - American Funds Short-Term Tax-Exempt Bond Fund Class A
ASTEX / American Funds Short-Term Tax-Exempt Bond Fund - American Funds Short-Term Tax-Exempt Bond Fund Class A
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
AUXL / Auxilium Pharmaceuticals Inc Call
AVNR / Avanir Pharmaceuticals Inc
AVNR / Avanir Pharmaceuticals Inc
BAX / Baxter International Inc.
BCRX / BioCryst Pharmaceuticals, Inc.
BMRN / BioMarin Pharmaceutical Inc.
BB / BlackBerry Limited
ZVO / Zovio Inc Put
ZVO / Zovio Inc Call
BMYMP / Bristol-Myers Squibb Company - Preferred Security
BMYMP / Bristol-Myers Squibb Company - Preferred Security
ACRX / Talphera, Inc.
DXTR / Dextera Surgical Inc.
CELG / Celgene Corp.
CELG / Celgene Corp.
CLDX / Celldex Therapeutics, Inc.
CLDX / Celldex Therapeutics, Inc.
CLDX / Celldex Therapeutics, Inc.
CLSN / Imunon Inc
MLNT / Melinta Therapeutics, Inc.
CERS / Cerus Corporation Call
CCXI / ChemoCentryx Inc
LLY / Eli Lilly and Company Call
CLSN / Imunon Inc
CNAT / Conatus Pharmaceuticals Inc.
CPRT / Copart, Inc. Call
CORONADO BIOSCIENCES INC / Call (21976U909)
CORONADO BIOSCIENCES INC / (21976U909)
CORONADO BIOSCIENCES INC / Put (21976U959)
CORONADO BIOSCIENCES INC / (21976U959)
OCUP / Opus Genetics, Inc.
CBST /
CBST /
CYBX / Cyberonics, Inc.
CYBX / Cyberonics, Inc.
DNDN /
DNDN / Call
DNDN /
DYAX / Dyax Corp.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
EW / Edwards Lifesciences Corporation
ELAN CORPORATION PLC - ADR / ADR Call (284131908)
ELAN CORPORATION PLC / ADR (284131908)
ENDO / Thermic Sciences International Put
ECYT / Endocyte, Inc.
ECYT / Endocyte, Inc.
ENTREMED INC / (29382F202)
EXAS / Exact Sciences Corporation
EXEL / Exelixis, Inc.
FCSC / Fibrocell Science Inc.
BIIB / Biogen Inc.
SLS / SELLAS Life Sciences Group, Inc.
ATHX / Athersys, Inc.
ATHX / Athersys, Inc.
GERN / Geron Corporation
GERN / Geron Corporation
GERN / Geron Corporation
GILD / Gilead Sciences, Inc.
GILD / Gilead Sciences, Inc.
GILD / Gilead Sciences, Inc.
GSK / GSK plc - Depositary Receipt (Common Stock)
GSK / GSK plc - Depositary Receipt (Common Stock)
GTXO / GTX Corp Call
HOLX / Hologic, Inc.
LLY / Eli Lilly and Company
IMUC / EOM Pharmaceuticals Holdings, Inc.
INCY / Incyte Corporation
INFI / Infinity Pharmaceuticals Inc.
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated
NSPR / InspireMD, Inc.
INTERMUNE INC / Call (45884X903)
INTERMUNE INC / (45884X903)
INTERMUNE INC / Put (45884X953)
INTERMUNE INC / (45884X953)
IHRMF / iShares Public Limited Company - iShares MSCI Japan UCITS ETF USD (Dist)
ISHARES MSCI JAPAN ETF / ETF (464286958)
TLT / iShares Trust - iShares 20+ Year Treasury Bond ETF
IONS / Ionis Pharmaceuticals, Inc.
IONS / Ionis Pharmaceuticals, Inc.
IONS / Ionis Pharmaceuticals, Inc.
ISR / Perspective Therapeutics Inc
HGEN / Humanigen, Inc.
KERX / Keryx Biopharmaceuticals, Inc.
KERX / Keryx Biopharmaceuticals, Inc.
KERX / Keryx Biopharmaceuticals, Inc.
LLY / Eli Lilly and Company
LINE / Lineage, Inc. Call
LINE / Lineage, Inc. Put
APEN / Apollo Endosurgery Inc
MEIP / MEI Pharma, Inc.
MAKO / Mako Surgical Corp. Call
MNKD / MannKind Corporation
MNKD / MannKind Corporation
MNKD / MannKind Corporation
SVRA / Savara Inc.
GNMX / Aevi Genomic Medicine, Inc.
MDCO / Medicines Company
MDVN / Medivation, Inc.
MDVN / Medivation, Inc.
MDVN / Medivation, Inc.
MRK / Merck & Co., Inc.
MRK / Merck & Co., Inc.
US60877T1007 / Momenta Pharmaceuticals, Inc.
MYGN / Myriad Genetics, Inc. Call
MYGN / Myriad Genetics, Inc. Put
NSPH / Nanosphere, Inc.
NAVB / Navidea Biopharmaceuticals, Inc. Call
NKTR / Nektar Therapeutics
NKTR / Nektar Therapeutics
NURO / NeuroMetrix, Inc.
NBIX / Neurocrine Biosciences, Inc.
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
LUMO / Lumos Pharma, Inc.
NVAX / Novavax, Inc.
NS / NuStar Energy L.P. - Limited Partnership
NS / NuStar Energy L.P. - Limited Partnership Call
NS / NuStar Energy L.P. - Limited Partnership Put
NUPATHE INC / (67059M950)
ACHV / Achieve Life Sciences, Inc.
ACHV / Achieve Life Sciences, Inc.
ONCY / Oncolytics Biotech Inc.
CASC / Cascadian Therapeutics, Inc.
ONTY / Oncothyreon, Inc.
ONXX / Onyx Pharmaceuticals Inc
ONYX / Onyx Acquisition Co. I
ONYX / Onyx Acquisition Co. I Put
OPK / OPKO Health, Inc.
OPK / OPKO Health, Inc.
OREX / Orexigen Therapeutics, Inc.
OREX / Orexigen Therapeutics, Inc.
TENX / Tenax Therapeutics, Inc.
PBF / PBF Energy Inc.
PTN / Palatin Technologies, Inc.
CDMO / Avid Bioservices, Inc.
CDMO / Avid Bioservices, Inc. Call
CDMO / Avid Bioservices, Inc. Put
PRGO / Perrigo Company plc Call
PCYC / Pharmacyclics
PCYC / Pharmacyclics
PCYC / Pharmacyclics
PSTI / Pluristem Therapeutics Inc
NVLN / NOVELION THERAPEUTICS INC.
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc.
76028H209 / Repros Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc.
RIGL / Rigel Pharmaceuticals, Inc.
RMTI / Rockwell Medical, Inc. Call
RMTI / Rockwell Medical, Inc. Put
SLXP / Salix Therapeuticals, Inc.
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc.
SQNM / Sequenom, Inc.
SQNM / Sequenom, Inc.
SQNM / Sequenom, Inc.
TVIA / TerraVia Holdings, Inc.
TVIA / TerraVia Holdings, Inc. Call
TVIA / TerraVia Holdings, Inc.
VIRX / Viracta Therapeutics, Inc.
VIRX / Viracta Therapeutics, Inc. Put
SCON / Superconductor Technologies Inc.
GEVA / Synageva Biopharma Corp
MDGL / Madrigal Pharmaceuticals, Inc.
MDGL / Madrigal Pharmaceuticals, Inc.
MDGL / Madrigal Pharmaceuticals, Inc.
SGYPW / Synergy Pharmaceuticals, Inc., Warrants Call
TRGT / Targacept Call
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
TGTX / TG Therapeutics, Inc.
TXMD / TherapeuticsMD, Inc.
INVA / Innoviva, Inc.
TMP / Tompkins Financial Corporation
TRANSCEPT PHARMACEUTICALS INC / (89354M106)
TRANSCEPT PHARMACEUTICALS / Put (89354M956)
TRANSCEPT PHARMACEUTICALS INC / (89354M956)
UNXLQ / Uni-Pixel, Inc.
UNXLQ / Uni-Pixel, Inc.
UTHR / United Therapeutics Corporation
91911K102 / Bausch Health Companies Call
VNDA / Vanda Pharmaceuticals Inc.
VNDA / Vanda Pharmaceuticals Inc.
VENTRUS BIOSCIENCES INC / (922822101)
VRTX / Vertex Pharmaceuticals Incorporated
VRTX / Vertex Pharmaceuticals Incorporated
VRTX / Vertex Pharmaceuticals Incorporated
BBI / Brickell Biotech Inc
BBI / Brickell Biotech Inc Call
BBI / Brickell Biotech Inc Put
/ VIVUS, Inc.
/ VIVUS, Inc.
WCG / Wellcare Health Plans, Inc.
ANTM / Anthem Inc Call
ANTM / Anthem Inc Put
XOMA / XOMA Royalty Corporation
XOMA / XOMA Royalty Corporation
ZIOP / Alaunos Therapeutics Inc
ZIOP / Alaunos Therapeutics Inc
ZTS / Zoetis Inc.
ZTS / Zoetis Inc. Call
ZTS / Zoetis Inc. Put
SEEL / Seelos Therapeutics, Inc.
TPST / Tempest Therapeutics, Inc.
OEF / iShares Trust - iShares S&P 100 ETF
IWM / iShares Trust - iShares Russell 2000 ETF Put
SPY / SPDR S&P 500 ETF
OEF / iShares Trust - iShares S&P 100 ETF
OEF / iShares Trust - iShares S&P 100 ETF