Market Value2,332,373,000
Total Holdings251
File Date2014-08-14
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price		 Prev
Shares		 Current
Shares		 Change
(Percent)		 Prev Value
(USD x1000)		 Current Value
(USD x1000)		 Change
(Percent)
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
ACAD / ACADIA Pharmaceuticals Inc.
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
ADXSW / Advaxis, Inc. Warrants
AEGR / Aegerion Pharmaceuticals, Inc. Call
AGEN / Agenus Inc.
AGEN / Agenus Inc. Put
ALXA / Alexza Pharmaceuticals, Inc. Call
ALIM / Alimera Sciences, Inc.
ALIM / Alimera Sciences, Inc. Call
ALIM / Alimera Sciences, Inc. Put
018490100 / Allergan plc Call
018490100 / Allergan plc Put
NWBO / Northwest Biotherapeutics, Inc. Call
NWBO / Northwest Biotherapeutics, Inc. Put
ALNY / Alnylam Pharmaceuticals, Inc.
ALNY / Alnylam Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Put
ATHX / Athersys, Inc. Put
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMGN / Amgen Inc.
AMGN / Amgen Inc. Put
FOLD / Amicus Therapeutics, Inc.
AMPE / Ampio Pharmaceuticals, Inc.
AMPE / Ampio Pharmaceuticals, Inc. Put
ANTH / Anthera Pharmaceuticals, Inc.
ANTH / Anthera Pharmaceuticals, Inc. Call
BLRX / BioLineRx Ltd. - Depositary Receipt (Common Stock)
ARNA / Arena Pharmaceuticals Inc
ARNA / Arena Pharmaceuticals Inc Call
ARNA / Arena Pharmaceuticals Inc Put
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Call
ARIA / ARIAD Pharmaceuticals, Inc. Put
ARROWHEAD RESEARCH CORP / (042797209)
ARROWHEAD RESEARCH CORP / Call (042797909)
ARROWHEAD RESEARCH CORP / Put (042797959)
SESN / Sesen Bio Inc.
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Call
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Put
ASPX / Auspex Pharmaceuticals, Inc.
AUXL / Auxilium Pharmaceuticals Inc Call
AVNR / Avanir Pharmaceuticals Inc
AVNR / Avanir Pharmaceuticals Inc Call
BCRX / BioCryst Pharmaceuticals, Inc.
BLUE / bluebird bio, Inc. Call
BMY / Bristol-Myers Squibb Company
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
BMYMP / Bristol-Myers Squibb Company - Preferred Security Put
19041P105 / CBS Corp.
ACRX / Talphera, Inc. Put
OUT / OUTFRONT Media Inc.
OUT / OUTFRONT Media Inc. Put
CVMW / CEL-SCI Corp. Warrants
PATI / Patriot Transportation Holding, Inc.
CELG / Celgene Corp. Call
CELG / Celgene Corp. Put
CLTX / Celsus Therapeutics
MLNT / Melinta Therapeutics, Inc.
CEMP / Cempra, Inc. Call
/ Ceres, Inc.
THMO / ThermoGenesis Holdings, Inc.
TENX / Tenax Therapeutics, Inc.
TENX / Tenax Therapeutics, Inc. Call
CLVS / Clovis Oncology Inc
CLVS / Clovis Oncology Inc Call
CLVS / Clovis Oncology Inc Put
CORI / Corium International, Inc.
CBST /
CBST / Put
CYTX / Cytori Therapeutics, Inc.
ASRT / Assertio Holdings, Inc. Call
DRNA / Dicerna Pharmaceuticals Inc
WINT / Windtree Therapeutics, Inc.
WINT / Windtree Therapeutics, Inc. Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
ATHX / Athersys, Inc. Call
PSTI / Pluristem Therapeutics Inc
ENTA / Enanta Pharmaceuticals, Inc. Call
ECYT / Endocyte, Inc. Call
ECYT / Endocyte, Inc. Put
EPZM / Epizyme Inc
EPZM / Epizyme Inc Call
EXEL / Exelixis, Inc.
EXEL / Exelixis, Inc. Call
EXEL / Exelixis, Inc. Put
BIIB / Biogen Inc. Call
BIIB / Biogen Inc. Put
FURX / Furiex Pharmaceuticals, Inc. Call
/ GW Pharmaceuticals Plc. Call
/ GW Pharmaceuticals Plc. Put
SLS / SELLAS Life Sciences Group, Inc.
SLS / SELLAS Life Sciences Group, Inc. Call
SLS / SELLAS Life Sciences Group, Inc. Put
GERN / Geron Corporation Call
GERN / Geron Corporation Put
GILD / Gilead Sciences, Inc. Call
GILD / Gilead Sciences, Inc. Put
ADXS / Ayala Pharmaceuticals, Inc. Put
BSTG / Biostage Inc
HRTX / Heron Therapeutics, Inc.
CVM / CEL-SCI Corporation
CBLI / Cytocom Inc
HZNP / Horizon Therapeutics Plc Put
IDRA / Idera Pharmaceuticals, Inc.
IDRA / Idera Pharmaceuticals, Inc. Call
451731103 / Ignyta, Inc.
IMUC / EOM Pharmaceuticals Holdings, Inc. Put
INCY / Incyte Corporation Call
TPST / Tempest Therapeutics, Inc.
INSM / Insmed Incorporated Call
INTERMUNE INC / Call (45884X903)
IPCI / Intellipharmaceutics International Inc.
INTERMUNE INC / Put (45884X953)
ICPT / Intercept Pharmaceuticals Inc Call
IOC / InterOil Corporation
IOC / InterOil Corporation Put
KYTH / Kythera Biopharma Call
GEVO / Gevo, Inc.
LPCN / Lipocine Inc.
SSKN / STRATA Skin Sciences, Inc.
MEIP / MEI Pharma, Inc.
MGNX / MacroGenics, Inc.
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
MDGN.WS / Medgenics, Inc., Warrant
MDCO / Medicines Company
MDCO / Medicines Company Put
MRK / Merck & Co., Inc. Put
NPSP / NPS Pharmaceuticals Inc
NPSP / NPS Pharmaceuticals Inc Put
NKTR / Nektar Therapeutics
NEOSTEM INC / (640650404)
NEOSTEM INC / Put (640650954)
NURO / NeuroMetrix, Inc.
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
LUMO / Lumos Pharma, Inc.
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
NVAX / Novavax, Inc.
NVAX / Novavax, Inc. Put
NONOF / Novo Nordisk A/S Put
OCRX / Ocera Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc. Call
NBSE / NeuBase Therapeutics, Inc. Put
ACHV / Achieve Life Sciences, Inc.
ACHV / Achieve Life Sciences, Inc. Call
ONTY / Oncothyreon, Inc. Call
OPK / OPKO Health, Inc.
OPK / OPKO Health, Inc. Call
OPK / OPKO Health, Inc. Put
OREX / Orexigen Therapeutics, Inc.
OREX / Orexigen Therapeutics, Inc. Put
OTLC / Oncotelic Therapeutics, Inc. Call
ALTO / Alto Ingredients, Inc.
ALTO / Alto Ingredients, Inc. Put
CDMO / Avid Bioservices, Inc.
PCYC / Pharmacyclics Put
PSTI / Pluristem Therapeutics Inc Put
PGNX / Progenics Pharmaceuticals, Inc.
PGNX / Progenics Pharmaceuticals, Inc. Call
PGNX / Progenics Pharmaceuticals, Inc. Put
PSDV / pSivida Corp. Call
PSDV / pSivida Corp. Put
PBYI / Puma Biotechnology, Inc. Call
PBYI / Puma Biotechnology, Inc. Put
QUINPARIO ACQUISITION CORP / (74874R108)
QUINPARIO ACQUISITION - CW18 / *W (74874R116)
REPH / Societal CDMO Inc
REGADO BIOSCIENCE INC / (75874Q107)
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc. Call
REGN / Regeneron Pharmaceuticals, Inc. Put
76028H209 / Repros Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc. Put
TVTX / Travere Therapeutics, Inc. Call
RVNC / Revance Therapeutics, Inc.
RIBT / RiceBran Technologies
RMTI / Rockwell Medical, Inc. Put
SPDR S&P BIOTECH / ETF Put (78464A950)
SLXP / Salix Therapeuticals, Inc.
SLXP / Salix Therapeuticals, Inc. Call
SLXP / Salix Therapeuticals, Inc. Put
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
ALBO / Albireo Pharma Inc Put
ALBO / Albireo Pharma Inc
SGEN / Seagen Inc Call
SGEN / Seagen Inc Put
SMLR / Semler Scientific, Inc.
OTLC / Oncotelic Therapeutics, Inc.
VIRX / Viracta Therapeutics, Inc. Call
VIRX / Viracta Therapeutics, Inc. Put
GEVA / Synageva Biopharma Corp Put
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
TPH / Tri Pointe Homes, Inc.
TPH / Tri Pointe Homes, Inc. Put
TSRO / TESARO, Inc. Call
TSRO / TESARO, Inc. Put
TSLA / Tesla, Inc.
TSLA / Tesla, Inc. Put
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
TNXP / Tonix Pharmaceuticals Holding Corp.
TROV / TrovaGene, Inc.
UTHR / United Therapeutics Corporation Call
UTHR / United Therapeutics Corporation Put
UNH / UnitedHealth Group Incorporated Call
VNDA / Vanda Pharmaceuticals Inc.
VNDA / Vanda Pharmaceuticals Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Call
VRTX / Vertex Pharmaceuticals Incorporated Put
/ VIVUS, Inc. Call
ADXS / Ayala Pharmaceuticals, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp. Put
ANTM / Anthem Inc Call
WY / Weyerhaeuser Company
WY / Weyerhaeuser Company Put
XNCR / Xencor, Inc.
XOMA / XOMA Royalty Corporation
XOMA / XOMA Royalty Corporation Call
XOMA / XOMA Royalty Corporation Put
ZIOP / Alaunos Therapeutics Inc Call
G0083B108 / Actavis
G0083B108 / Actavis Call
G0083B108 / Actavis Put
ALKS / Alkermes plc Call
PRTA / Prothena Corporation plc
PRTA / Prothena Corporation plc Put
ADHD / Alcobra Ltd. Put
CGEN / Compugen Ltd. Call
GLMD / Galmed Pharmaceuticals Ltd.
QURE / uniQure N.V.
CLSN / Imunon Inc
CLSN / Imunon Inc Put
SEEL / Seelos Therapeutics, Inc.
SEEL / Seelos Therapeutics, Inc. Put
ACRX / Talphera, Inc.
IWM / iShares Trust - iShares Russell 2000 ETF Put
OEF / iShares Trust - iShares S&P 100 ETF Put