Market Value2,600,069,000
Total Holdings254
File Date2014-11-14
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
(USD x1000)
Current Value
(USD x1000)
Change
(Percent)
ALBO / Albireo Pharma Inc Put
ALBO / Albireo Pharma Inc
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
WINT / Windtree Therapeutics, Inc. Call
TSRO / TESARO, Inc. Call
INSM / Insmed Incorporated
INSM / Insmed Incorporated Call
GILD / Gilead Sciences, Inc. Call
INTERMUNE INC / Call (45884X903)
ADHD / Alcobra Ltd. Put
QRHC / Quest Resource Holding Corporation
REGADO BIOSCIENCE INC / (75874Q107)
MDGN / Medgenics, Inc. Put
PBYI / Puma Biotechnology, Inc. Call
PBYI / Puma Biotechnology, Inc. Put
CLRB / Cellectar Biosciences, Inc.
CTIC / CTI BioPharma Corp Put
SHPG / Shire Plc.
GEVA / Synageva Biopharma Corp
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
ARIA / ARIAD Pharmaceuticals, Inc.
OTLC / Oncotelic Therapeutics, Inc. Call
BIIB / Biogen Inc. Call
ABBV / AbbVie Inc. Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
PRQR / ProQR Therapeutics N.V.
AMGN / Amgen Inc. Put
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Call
AMPE / Ampio Pharmaceuticals, Inc.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
BMY / Bristol-Myers Squibb Company
CNAT / Conatus Pharmaceuticals Inc.
REPH / Societal CDMO Inc
ABUS / Arbutus Biopharma Corporation Put
NPSP / NPS Pharmaceuticals Inc
COVIDIEN PLC / SHS Put (G2554F953)
MRK / Merck & Co., Inc. Call
MRK / Merck & Co., Inc. Put
UTHR / United Therapeutics Corporation Call
UTHR / United Therapeutics Corporation Put
NWBO / Northwest Biotherapeutics, Inc. Put
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
DXTR / Dextera Surgical Inc.
RCPT / Receptos, Inc. Call
US00448Q2012 / Achillion Pharmaceuticals, Inc.
LUMO / Lumos Pharma, Inc.
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
INCY / Incyte Corporation Call
CASC / Cascadian Therapeutics, Inc.
TROV / TrovaGene, Inc.
OPK / OPKO Health, Inc. Call
OPK / OPKO Health, Inc. Put
XOMA / XOMA Royalty Corporation
XOMA / XOMA Royalty Corporation Put
LRMR / Larimar Therapeutics, Inc.
SGEN / Seagen Inc Put
MDGN.WS / Medgenics, Inc., Warrant
NKTR / Nektar Therapeutics
ALKS / Alkermes plc
WY / Weyerhaeuser Company
FOLD / Amicus Therapeutics, Inc.
MDCO / Medicines Company Put
MDCO / Medicines Company
VNDA / Vanda Pharmaceuticals Inc.
IPCI / Intellipharmaceutics International Inc. Put
IPCI / Intellipharmaceutics International Inc.
ALTO / Alto Ingredients, Inc.
ALTO / Alto Ingredients, Inc. Put
MDVN / Medivation, Inc. Call
MDVN / Medivation, Inc. Put
CLVS / Clovis Oncology Inc
ACAD / ACADIA Pharmaceuticals Inc.
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
ALKS / Alkermes plc Call
BSTG / Biostage Inc
SHPG / Shire Plc. Put
881569AA5 / TESARO, Inc. Bond 3.000%10/0
AVNR / Avanir Pharmaceuticals Inc
ABUS / Arbutus Biopharma Corporation Call
ACHC / Acadia Healthcare Company, Inc. Call
SLXP / Salix Therapeuticals, Inc. Put
G0083B108 / Actavis
EXAS / Exact Sciences Corporation Put
KOOL / Spinnaker ETF Series - North Shore Equity Rotation ETF
ALKS / Alkermes plc Put
EXAS / Exact Sciences Corporation
TENX / Tenax Therapeutics, Inc. Call
018490100 / Allergan plc Call
INTERMUNE INC / Put (45884X953)
BLRX / BioLineRx Ltd. - Depositary Receipt (Common Stock)
IRWD / Ironwood Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Call
HZNP / Horizon Therapeutics Plc Call
HRTX / Heron Therapeutics, Inc.
CBST /
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Call
CGEN / Compugen Ltd.
ZIOP / Alaunos Therapeutics Inc Call
GILD / Gilead Sciences, Inc. Put
ACHC / Acadia Healthcare Company, Inc.
ADVM / Adverum Biotechnologies, Inc.
TRUP / Trupanion, Inc.
EIGR / Eiger BioPharmaceuticals, Inc.
UNH / UnitedHealth Group Incorporated Call
SPDR S&P BIOTECH / ETF Put (78464A950)
BMYMP / Bristol-Myers Squibb Company - Preferred Security Put
IDRA / Idera Pharmaceuticals, Inc.
SEEL / Seelos Therapeutics, Inc.
EXEL / Exelixis, Inc. Put
PGNX / Progenics Pharmaceuticals, Inc. Put
CASI / CASI Pharmaceuticals, Inc.
RMTI / Rockwell Medical, Inc.
WY / Weyerhaeuser Company Put
ACHC / Acadia Healthcare Company, Inc. Put
ALIM / Alimera Sciences, Inc.
NEOSTEM INC / Call (640650904)
ARROWHEAD RESEARCH CORP / (042797209)
SEEL / Seelos Therapeutics, Inc. Put
G0083B108 / Actavis Put
NEOSTEM INC / (640650404)
NEOSTEM INC / Put (640650954)
OUT / OUTFRONT Media Inc.
OUT / OUTFRONT Media Inc. Put
ALNY / Alnylam Pharmaceuticals, Inc. Put
CEMP / Cempra, Inc. Put
018490100 / Allergan plc Put
WGBS / WaferGen Bio-Systems, Inc.
CELG / Celgene Corp. Call
CELG / Celgene Corp. Put
ECYT / Endocyte, Inc.
ECYT / Endocyte, Inc. Call
ECYT / Endocyte, Inc. Put
ENTA / Enanta Pharmaceuticals, Inc. Call
CGEN / Compugen Ltd. Call
PCYC / Pharmacyclics Put
OREX / Orexigen Therapeutics, Inc.
OREX / Orexigen Therapeutics, Inc. Put
PSDV / pSivida Corp. Put
AEGR / Aegerion Pharmaceuticals, Inc. Call
ARNA / Arena Pharmaceuticals Inc Call
ARNA / Arena Pharmaceuticals Inc Put
ONTY / Oncothyreon, Inc. Call
AMT.PRB / American Tower Corp Call
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Put
AMT.PRB / American Tower Corp Put
XNCR / Xencor, Inc.
CBAY / CymaBay Therapeutics, Inc.
ARROWHEAD RESEARCH CORP / Put (042797959)
ANTH / Anthera Pharmaceuticals, Inc.
CLSN / Imunon Inc Put
IDRA / Idera Pharmaceuticals, Inc. Call
BLUE / bluebird bio, Inc. Call
QUINPARIO ACQUISITION CORP / (74874R108)
VNDA / Vanda Pharmaceuticals Inc. Call
SLS / SELLAS Life Sciences Group, Inc.
/ Ceres, Inc.
TPH / Tri Pointe Homes, Inc. Put
HZNP / Horizon Therapeutics Plc Put
SLS / SELLAS Life Sciences Group, Inc. Put
/ VIVUS, Inc. Call
PGNX / Progenics Pharmaceuticals, Inc.
AMPE / Ampio Pharmaceuticals, Inc. Put
CTIC / CTI BioPharma Corp Call
A / Agilent Technologies, Inc. Put
CVMW / CEL-SCI Corp. Warrants
COV /
CYTX / Cytori Therapeutics, Inc.
CORI / Corium International, Inc.
KERX / Keryx Biopharmaceuticals, Inc. Put
ANTH / Anthera Pharmaceuticals, Inc. Call
GERN / Geron Corporation Put
PRTA / Prothena Corporation plc
76028H209 / Repros Therapeutics, Inc. Call
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
KERX / Keryx Biopharmaceuticals, Inc. Call
KYTH / Kythera Biopharma Call
CBST / Put
EPZM / Epizyme Inc
EPZM / Epizyme Inc Call
19041P105 / CBS Corp.
OPK / OPKO Health, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
15117F112 / Cellectar Biosciences, Inc. Series A Warrants
ASPX / Auspex Pharmaceuticals, Inc.
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
FOMX / Foamix Pharmaceuticals Ltd.
PSDV / pSivida Corp.
NONOF / Novo Nordisk A/S Put
GEVO / Gevo, Inc.
AAPL / Apple Inc. Call
AASTROM BIOSCIENCES INC / (00253U404)
MGNX / MacroGenics, Inc.
PSDV / pSivida Corp. Call
CEMP / Cempra, Inc. Call
TPH / Tri Pointe Homes, Inc.
ADHD / Alcobra Ltd. Call
DRNA / Dicerna Pharmaceuticals Inc
MLNT / Melinta Therapeutics, Inc.
US249908AA20 / DepoMed, Inc. 2.5% Bond Due 9/1/2021
GERN / Geron Corporation Call
NPSP / NPS Pharmaceuticals Inc Call
ARNA / Arena Pharmaceuticals Inc
ARIA / ARIAD Pharmaceuticals, Inc. Put
ARROWHEAD RESEARCH CORP / Call (042797909)
OTLC / Oncotelic Therapeutics, Inc. Put
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
CBLI / Cytocom Inc
BLUE / bluebird bio, Inc.
BAXS / Baxano Surgical, Inc.
GEVA / Synageva Biopharma Corp Put
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
EXEL / Exelixis, Inc. Call
G0083B108 / Actavis Call
DYAX / Dyax Corp. Call
NPSP / NPS Pharmaceuticals Inc Put
QUINPARIO ACQUISITION - CW18 / *W (74874R116)
AMGN / Amgen Inc. Call
EXEL / Exelixis, Inc.
ACHV / Achieve Life Sciences, Inc.
ACHV / Achieve Life Sciences, Inc. Call
WINT / Windtree Therapeutics, Inc.
SLXP / Salix Therapeuticals, Inc.
FURX / Furiex Pharmaceuticals, Inc. Call
SLXP / Salix Therapeuticals, Inc. Call
PGNX / Progenics Pharmaceuticals, Inc. Call
QURE / uniQure N.V.
IOC / InterOil Corporation
IOC / InterOil Corporation Put
SMLR / Semler Scientific, Inc.
OCRX / Ocera Therapeutics, Inc.
ADXSW / Advaxis, Inc. Warrants
AVNR / Avanir Pharmaceuticals Inc Call
ALXA / Alexza Pharmaceuticals, Inc. Call
ALIM / Alimera Sciences, Inc. Call
ALIM / Alimera Sciences, Inc. Put
AUXL / Auxilium Pharmaceuticals Inc Call
76028H209 / Repros Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc. Put
AAPL / Apple Inc. Put
ARIA / ARIAD Pharmaceuticals, Inc. Call
CLTX / Celsus Therapeutics
BCLI / Brainstorm Cell Therapeutics Inc.
APEN / Apollo Endosurgery Inc
451731103 / Ignyta, Inc.
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc. Call
REGN / Regeneron Pharmaceuticals, Inc. Put
SESN / Sesen Bio Inc.
ALNY / Alnylam Pharmaceuticals, Inc.
RMTI / Rockwell Medical, Inc. Put
GLMD / Galmed Pharmaceuticals Ltd.
OTLC / Oncotelic Therapeutics, Inc.
GWP / GW Pharmaceuticals plc Call
TSLA / Tesla, Inc.
CLVS / Clovis Oncology Inc Put
OCUL / Ocular Therapeutix, Inc.
BIIB / Biogen Inc. Put
ASRT / Assertio Holdings, Inc. Call
NVAX / Novavax, Inc. Put
/ GW Pharmaceuticals Plc. Put
PRTA / Prothena Corporation plc Put
PATI / Patriot Transportation Holding, Inc.
A / Agilent Technologies, Inc. Call
ICPT / Intercept Pharmaceuticals Inc Call
RIBT / RiceBran Technologies
ATHX / Athersys, Inc. Put
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
ANTM / Anthem Inc Call
AMGN / Amgen Inc.
ATHX / Athersys, Inc. Call
ACRX / Talphera, Inc. Put
TTOO / T2 Biosystems, Inc.
PGEN / Precigen, Inc. Call
SGEN / Seagen Inc
SGEN / Seagen Inc Call
CLSN / Imunon Inc
AGEN / Agenus Inc. Put
IONS / Ionis Pharmaceuticals, Inc. Call
NVAX / Novavax, Inc.
IMUC / EOM Pharmaceuticals Holdings, Inc. Put
PFE / Pfizer Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Call
VRTX / Vertex Pharmaceuticals Incorporated Put
MEIP / MEI Pharma, Inc.
XOMA / XOMA Royalty Corporation Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
BCRX / BioCryst Pharmaceuticals, Inc.
INFI / Infinity Pharmaceuticals Inc.
INFI / Infinity Pharmaceuticals Inc. Call
INFI / Infinity Pharmaceuticals Inc. Put
CVM / CEL-SCI Corporation
TNXP / Tonix Pharmaceuticals Holding Corp.
TSRO / TESARO, Inc. Put
PGEN / Precigen, Inc.
PGEN / Precigen, Inc. Put
ITP / IT Tech Packaging, Inc.
TSLA / Tesla, Inc. Put
CLVS / Clovis Oncology Inc Call
ABBV / AbbVie Inc. Put
PSTI / Pluristem Therapeutics Inc
PSTI / Pluristem Therapeutics Inc Put
TNXP / Tonix Pharmaceuticals Holding Corp. Call
ALT / Altimmune, Inc. Call
TVTX / Travere Therapeutics, Inc. Call
SKBI / Skystar Bio-Pharmaceutical Company
MBOT / Microbot Medical Inc.
RVNC / Revance Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc. Call
TENX / Tenax Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
ACRX / Talphera, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
CDMO / Avid Bioservices, Inc.
VIRX / Viracta Therapeutics, Inc. Call
VIRX / Viracta Therapeutics, Inc. Put
SLS / SELLAS Life Sciences Group, Inc. Call
SSKN / STRATA Skin Sciences, Inc.
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
NWBO / Northwest Biotherapeutics, Inc. Call
LPCN / Lipocine Inc.
NBSE / NeuBase Therapeutics, Inc. Put
ADXS / Ayala Pharmaceuticals, Inc.
ADXS / Ayala Pharmaceuticals, Inc. Put
NURO / NeuroMetrix, Inc.
TPST / Tempest Therapeutics, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp. Put
SPY / SPDR S&P 500 ETF Put
OEF / iShares Trust - iShares S&P 100 ETF Put
LLY / Eli Lilly and Company Call