Market Value2,401,968,000
Total Holdings284
File Date2015-05-15
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
(USD x1000)
Current Value
(USD x1000)
Change
(Percent)
NURO / NeuroMetrix, Inc.
AGIO / Agios Pharmaceuticals, Inc.
AGIO / Agios Pharmaceuticals, Inc. Call
AGIO / Agios Pharmaceuticals, Inc. Put
ADVM / Adverum Biotechnologies, Inc.
TSRO / TESARO, Inc. Call
NWBO / Northwest Biotherapeutics, Inc. Put
COVIDIEN PLC / SHS Put (G2554F953)
SPDR S&P BIOTECH ETF / ETF Put (78464A950)
INSM / Insmed Incorporated Call
CTSO / Cytosorbents Corporation Put
ARROWHEAD RESEARCH CORP / Call (042797909)
PMAH / PlasmaTech, Inc.
IOVA / Iovance Biotherapeutics, Inc.
SCON / Superconductor Technologies Inc.
EXEL / Exelixis, Inc. Put
PBYI / Puma Biotechnology, Inc. Call
ICPT / Intercept Pharmaceuticals Inc Call
GEVA / Synageva Biopharma Corp Put
GEVA / Synageva Biopharma Corp
IDRA / Idera Pharmaceuticals, Inc. Put
DERM / Journey Medical Corporation
BDSI / Biodelivery Sciences International Call
AXGN / Axogen, Inc.
CYTX / Cytori Therapeutics, Inc.
MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF
QRHC / Quest Resource Holding Corporation
ABUS / Arbutus Biopharma Corporation
SESN / Sesen Bio Inc.
MRK / Merck & Co., Inc.
MRK / Merck & Co., Inc. Call
MRK / Merck & Co., Inc. Put
ESPR / Esperion Therapeutics, Inc. Call
ESPR / Esperion Therapeutics, Inc.
UTHR / United Therapeutics Corporation Call
BDSI / Biodelivery Sciences International Put
INCY / Incyte Corporation Call
ZSAN / Zosano Pharma Corp
INCY / Incyte Corporation Put
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
451731103 / Ignyta, Inc.
584688AC9 / Medicines Company 1.375% Bond due 2017-06-01
/ Immunomedics, Inc.
COLLABRX INC / (19422J108)
THMO / ThermoGenesis Holdings, Inc.
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
ACRX / Talphera, Inc. Call
ADVM / Adverum Biotechnologies, Inc. Call
CASC / Cascadian Therapeutics, Inc.
CBST / Call
EPZM / Epizyme Inc
NKTR / Nektar Therapeutics Call
TROV / TrovaGene, Inc.
AMT.PRB / American Tower Corp Call
OPK / OPKO Health, Inc.
OPK / OPKO Health, Inc. Call
LRMR / Larimar Therapeutics, Inc.
15117F112 / Cellectar Biosciences, Inc. Series A Warrants
REGN / Regeneron Pharmaceuticals, Inc. Put
GWP / GW Pharmaceuticals plc
G0083B108 / Actavis Call
RPTP / Raptor Pharmaceutical Corp. Call
IDRA / Idera Pharmaceuticals, Inc.
IDRA / Idera Pharmaceuticals, Inc. Call
INCY / Incyte Corporation
CASI / CASI Pharmaceuticals, Inc.
HALO / Halozyme Therapeutics, Inc. Call
ARNA / Arena Pharmaceuticals Inc Call
SGEN / Seagen Inc Call
CLSN / Imunon Inc Put
GILD / Gilead Sciences, Inc.
GILD / Gilead Sciences, Inc. Call
PFE / Pfizer Inc.
CLDX / Celldex Therapeutics, Inc. Call
CLDX / Celldex Therapeutics, Inc. Put
FOLD / Amicus Therapeutics, Inc. Call
FOLD / Amicus Therapeutics, Inc. Put
FOLD / Amicus Therapeutics, Inc.
MDCO / Medicines Company Put
ALNY / Alnylam Pharmaceuticals, Inc. Call
MBLY / Mobileye Global Inc.
MBLY / Mobileye Global Inc. Call
VNDA / Vanda Pharmaceuticals Inc. Call
RMTI / Rockwell Medical, Inc.
DXTR / Dextera Surgical Inc.
MDVN / Medivation, Inc. Call
RCPT / Receptos, Inc. Call
CNAT / Conatus Pharmaceuticals Inc. Call
CVM / CEL-SCI Corporation
BIIB / Biogen Inc. Call
BIIB / Biogen Inc. Put
ALKS / Alkermes plc
ACAD / ACADIA Pharmaceuticals Inc.
ACAD / ACADIA Pharmaceuticals Inc. Call
MBLY / Mobileye Global Inc. Put
TLT / iShares Trust - iShares 20+ Year Treasury Bond ETF
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
RCPT / Receptos, Inc. Put
KITE / Kite Pharma, Inc. Put
VCEL / Vericel Corporation
ALT / Altimmune, Inc. Call
ASPX / Auspex Pharmaceuticals, Inc.
ACHV / Achieve Life Sciences, Inc.
ACHC / Acadia Healthcare Company, Inc. Call
RGLS / Regulus Therapeutics Inc.
BDSI / Biodelivery Sciences International
NXTM / NxStage Medical, Inc. Call
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
IOC / InterOil Corporation
HZNP / Horizon Therapeutics Plc Put
ASND / Ascendis Pharma A/S - Depositary Receipt (Common Stock)
G0083B108 / Actavis
PRGO / Perrigo Company plc Call
NUVA / Nuvasive Inc Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
AMT.PRB / American Tower Corp Put
CSLT / Castlight Health Inc - Class B Call
ARROWHEAD RESEARCH CORP / Put (042797959)
SHPG / Shire Plc.
FGEN / FibroGen, Inc.
PGNX / Progenics Pharmaceuticals, Inc. Put
/ Ceres, Inc.
SHPG / Shire Plc. Put
30161QAC8 / Exelixis, Inc. Bond
ZGNX / Zogenix Inc Call
SNOA / Sonoma Pharmaceuticals, Inc.
TPST / Tempest Therapeutics, Inc. Call
AEGR / Aegerion Pharmaceuticals, Inc. Call
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
HZNP / Horizon Therapeutics Plc Call
KERX / Keryx Biopharmaceuticals, Inc. Call
KERX / Keryx Biopharmaceuticals, Inc.
KERX / Keryx Biopharmaceuticals, Inc. Put
BMRN / BioMarin Pharmaceutical Inc.
BMRN / BioMarin Pharmaceutical Inc. Call
ZGNX / Zogenix Inc
MLNT / Melinta Therapeutics, Inc.
881569AA5 / TESARO, Inc. Bond 3.000%10/0
ITCI / Intra-Cellular Therapies, Inc.
BMYMP / Bristol-Myers Squibb Company - Preferred Security Put
09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018
HTWR / Heartware International Inc. Put
SCON / Superconductor Technologies Inc. Put
CVMW / CEL-SCI Corp. Warrants
NONOF / Novo Nordisk A/S Call
HALO / Halozyme Therapeutics, Inc.
CYTX / Cytori Therapeutics, Inc. Put
TRUP / Trupanion, Inc.
EIGR / Eiger BioPharmaceuticals, Inc. Call
CSLT / Castlight Health Inc - Class B
CERS / Cerus Corporation
REGADO BIOSCIENCE INC / (75874Q107)
ALDR / Alder BioPharmaceuticals, Inc.
MEIP / MEI Pharma, Inc. Call
KYTH / Kythera Biopharma Put
US00C4U1L353 / Mylan N.V.
US00C4U1L353 / Mylan N.V. Put
CEMP / Cempra, Inc. Put
PATI / Patriot Transportation Holding, Inc.
WGBS / WaferGen Bio-Systems, Inc.
COV /
RIBT / RiceBran Technologies
ARROWHEAD RESEARCH CORP / (042797209)
HALO / Halozyme Therapeutics, Inc. Put
NSPH / Nanosphere, Inc.
G0083B108 / Actavis Put
BMRN / BioMarin Pharmaceutical Inc. Put
TTHI / Transition Therapeutics Inc.
EXEL / Exelixis, Inc. Call
CLLS / Cellectis S.A. - Depositary Receipt (Common Stock)
FOMX / Foamix Pharmaceuticals Ltd.
RGLS / Regulus Therapeutics Inc. Call
PLASMATECH BIOPHARMACEUTICALS / *W (72754H117)
ACHC / Acadia Healthcare Company, Inc.
NPSP / NPS Pharmaceuticals Inc Call
FWP / Forward Pharma A/S - ADR
G0083B108 / Actavis Call
ACHC / Acadia Healthcare Company, Inc. Put
VNDA / Vanda Pharmaceuticals Inc.
CEMP / Cempra, Inc. Call
NPSP / NPS Pharmaceuticals Inc
SLXP / Salix Therapeuticals, Inc. Call
PGNX / Progenics Pharmaceuticals, Inc.
IOC / InterOil Corporation Put
MDGN.WS / Medgenics, Inc., Warrant
SMLR / Semler Scientific, Inc.
OCRX / Ocera Therapeutics, Inc.
DRNA / Dicerna Pharmaceuticals Inc
ALXA / Alexza Pharmaceuticals, Inc. Call
AUXL / Auxilium Pharmaceuticals Inc Call
76028H209 / Repros Therapeutics, Inc. Call
REPH / Societal CDMO Inc
76028H209 / Repros Therapeutics, Inc. Put
CLTX / Celsus Therapeutics
DYAX / Dyax Corp. Put
76028H209 / Repros Therapeutics, Inc.
MDCO / Medicines Company Call
EXAS / Exact Sciences Corporation Put
APEN / Apollo Endosurgery Inc
CBLI / Cytocom Inc
REGN / Regeneron Pharmaceuticals, Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RMTI / Rockwell Medical, Inc. Call
RMTI / Rockwell Medical, Inc. Put
MNKKQ / Mallinckrodt Plc
OTLC / Oncotelic Therapeutics, Inc.
885175307 / Thoratec Call
NHWK / NightHawk Biosciences, Inc.
OCUL / Ocular Therapeutix, Inc.
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Put
DARA / DARA Biosciences, Inc.
/ GW Pharmaceuticals Plc. Put
/ GW Pharmaceuticals Plc. Call
XNPT / XenoPort, Inc. Call
KEYS / Keysight Technologies, Inc.
SRPT / Sarepta Therapeutics, Inc.
US249908AA20 / DepoMed, Inc. 2.5% Bond Due 9/1/2021
MNKKQ / Mallinckrodt Plc Put
LLY / Eli Lilly and Company Call
LLY / Eli Lilly and Company Put
GALT / Galectin Therapeutics Inc.
A / Agilent Technologies, Inc.
ICPT / Intercept Pharmaceuticals Inc Put
TXMD / TherapeuticsMD, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
A / Agilent Technologies, Inc. Call
A / Agilent Technologies, Inc. Put
DYAX / Dyax Corp. Call
AMGN / Amgen Inc. Call
CYCC / Cyclacel Pharmaceuticals, Inc.
XOMA / XOMA Royalty Corporation
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Call
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Put
IPCI / Intellipharmaceutics International Inc. Put
IPCI / Intellipharmaceutics International Inc.
NVAX / Novavax, Inc. Put
SGEN / Seagen Inc Put
SGEN / Seagen Inc
CELG / Celgene Corp. Call
CELG / Celgene Corp.
CELG / Celgene Corp. Put
IONS / Ionis Pharmaceuticals, Inc. Call
IONS / Ionis Pharmaceuticals, Inc. Put
GNCA / Genocea Biosciences Inc
IMUC / EOM Pharmaceuticals Holdings, Inc.
PFE / Pfizer Inc. Put
PFE / Pfizer Inc. Call
APDNW / Applied DNA Sciences, Inc., Warrants
ENDP / Endo International plc
ENDP / Endo International plc Call
TXMD / TherapeuticsMD, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Put
ARIA / ARIAD Pharmaceuticals, Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Put
VRTX / Vertex Pharmaceuticals Incorporated Call
DHR / Danaher Corporation
DHR / Danaher Corporation Call
DHR / Danaher Corporation Put
MEIP / MEI Pharma, Inc.
018490100 / Allergan plc Call
GEVO / Gevo, Inc.
XOMA / XOMA Royalty Corporation Call
XOMA / XOMA Royalty Corporation Put
INFI / Infinity Pharmaceuticals Inc. Call
INFI / Infinity Pharmaceuticals Inc. Put
BCRX / BioCryst Pharmaceuticals, Inc. Call
BCRX / BioCryst Pharmaceuticals, Inc. Put
SLS / SELLAS Life Sciences Group, Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp.
PBYI / Puma Biotechnology, Inc.
PBYI / Puma Biotechnology, Inc. Put
CERN / Cerner Corp. Call
CERN / Cerner Corp. Put
PGEN / Precigen, Inc. Put
GILD / Gilead Sciences, Inc. Put
HCA / HCA Healthcare, Inc. Call
PGEN / Precigen, Inc. Call
ITP / IT Tech Packaging, Inc.
OCGN / Ocugen, Inc.
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
PSTI / Pluristem Therapeutics Inc Put
BLPH / Bellerophon Therapeutics, Inc.
AGTC / Applied Genetic Technologies Corp
NVAX / Novavax, Inc. Call
THC / Tenet Healthcare Corporation
THC / Tenet Healthcare Corporation Call
THC / Tenet Healthcare Corporation Put
PTCT / PTC Therapeutics, Inc. Call
PCYC / Pharmacyclics Call
PCYC / Pharmacyclics Put
CTIC / CTI BioPharma Corp Put
CTIC / CTI BioPharma Corp
CTIC / CTI BioPharma Corp Call
TTOO / T2 Biosystems, Inc.
OPK / OPKO Health, Inc. Put
PRQR / ProQR Therapeutics N.V.
OMER / Omeros Corporation Call
OMER / Omeros Corporation Put
CYTR / LadRx Corp Put
LXRX / Lexicon Pharmaceuticals, Inc.
ARDX / Ardelyx, Inc.
SKBI / Skystar Bio-Pharmaceutical Company
APDN / Applied DNA Sciences, Inc.
NSPR / InspireMD, Inc.
ATHX / Athersys, Inc. Call
ATHX / Athersys, Inc. Put
US00448Q2012 / Achillion Pharmaceuticals, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
BLUE / bluebird bio, Inc. Put
BLUE / bluebird bio, Inc. Call
PSTI / Pluristem Therapeutics Inc
RVNC / Revance Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc. Put
NBSE / NeuBase Therapeutics, Inc. Call
TENX / Tenax Therapeutics, Inc.
CYH / Community Health Systems, Inc.
CYH / Community Health Systems, Inc. Call
CYH / Community Health Systems, Inc. Put
HRTX / Heron Therapeutics, Inc.
HRTX / Heron Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
BIOL / BIOLASE, Inc.
MDGL / Madrigal Pharmaceuticals, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
CDMO / Avid Bioservices, Inc.
CBAY / CymaBay Therapeutics, Inc.
SEEL / Seelos Therapeutics, Inc. Put
TPST / Tempest Therapeutics, Inc.
ALKS / Alkermes plc Call
ALKS / Alkermes plc Put
VIRX / Viracta Therapeutics, Inc.
VIRX / Viracta Therapeutics, Inc. Call
VIRX / Viracta Therapeutics, Inc. Put
SLS / SELLAS Life Sciences Group, Inc.
SLS / SELLAS Life Sciences Group, Inc. Put
CLRB / Cellectar Biosciences, Inc.
SSKN / STRATA Skin Sciences, Inc.
ABIO / ARCA biopharma, Inc.
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
XTLB / XTL Biopharmaceuticals Ltd. - Depositary Receipt (Common Stock)
MBOT / Microbot Medical Inc.
ACRX / Talphera, Inc. Put
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
GBSN / Great Basin Scientific, Inc.
CLSN / Imunon Inc
BCLI / Brainstorm Cell Therapeutics Inc.
ALBO / Albireo Pharma Inc
ALBO / Albireo Pharma Inc Put
ACRX / Talphera, Inc.
BLRX / BioLineRx Ltd. - Depositary Receipt (Common Stock)
OEF / iShares Trust - iShares S&P 100 ETF Put
IWM / iShares Trust - iShares Russell 2000 ETF
SPY / SPDR S&P 500 ETF Put
OEF / iShares Trust - iShares S&P 100 ETF Put