Market Value2,427,276,000
Total Holdings379
File Date2015-11-16
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
(USD x1000)
Current Value
(USD x1000)
Change
(Percent)
ADXS / Ayala Pharmaceuticals, Inc.
ADXS / Ayala Pharmaceuticals, Inc. Call
OTLC / Oncotelic Therapeutics, Inc.
GBSN / Great Basin Scientific, Inc.
OEF / iShares Trust - iShares S&P 100 ETF Put
TNXP / Tonix Pharmaceuticals Holding Corp. Call
AGIO / Agios Pharmaceuticals, Inc.
AGIO / Agios Pharmaceuticals, Inc. Call
AGIO / Agios Pharmaceuticals, Inc. Put
PRQR / ProQR Therapeutics N.V.
ADVM / Adverum Biotechnologies, Inc.
TSRO / TESARO, Inc. Put
NVAX / Novavax, Inc.
CYTR / LadRx Corp
US29266S3040 / Endologix, Inc.
GWP / GW Pharmaceuticals plc
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated Put
FEIC / FEI Company Call
ALBO / Albireo Pharma Inc Put
SCON / Superconductor Technologies Inc.
ALBO / Albireo Pharma Inc
ADXS / Ayala Pharmaceuticals, Inc. Put
PBYI / Puma Biotechnology, Inc.
EXEL / Exelixis, Inc. Call
EXEL / Exelixis, Inc. Put
PBYI / Puma Biotechnology, Inc. Call
MNKKQ / Mallinckrodt Plc Call
WINT / Windtree Therapeutics, Inc.
FOMX / Foamix Pharmaceuticals Ltd.
MDCO / Medicines Company Call
ZLTQ / ZELTIQ Aesthetics, Inc. Call
CYTX / Cytori Therapeutics, Inc.
30161QAC8 / Exelixis, Inc. Bond
BNTCW / Benitec Biopharma Ltd
PHG / Koninklijke Philips N.V. - Depositary Receipt (Common Stock) Call
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019
EXAS / Exact Sciences Corporation Put
NUVA / Nuvasive Inc Call
ASND / Ascendis Pharma A/S - Depositary Receipt (Common Stock)
QURE / uniQure N.V. Put
CEMP / Cempra, Inc. Put
JUNO / Juno Therapeutics, Inc. Put
JUNO / Juno Therapeutics, Inc.
SKY / Champion Homes, Inc.
IONS / Ionis Pharmaceuticals, Inc. Call
CNAT / Conatus Pharmaceuticals Inc.
ABUS / Arbutus Biopharma Corporation
ABUS / Arbutus Biopharma Corporation Call
MRK / Merck & Co., Inc.
MRK / Merck & Co., Inc. Call
MRK / Merck & Co., Inc. Put
UTHR / United Therapeutics Corporation Call
BDSI / Biodelivery Sciences International
BDSI / Biodelivery Sciences International Call
BDSI / Biodelivery Sciences International Put
PRSN / Perseon Corporation
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
AOXG / Aoxing Pharmaceutical Company, Inc.
TROV / TrovaGene, Inc. Call
032420101 / Anacor Pharmaceuticals, Inc. Put
TBRA / Tobira Therapeutics, Inc.
QURE / uniQure N.V. Call
NDRM / NeuroDerm Ltd.
THMO / ThermoGenesis Holdings, Inc.
RLYP / Relypsa, Inc.
RLYP / Relypsa, Inc. Call
GMED / Globus Medical, Inc. Put
US0153511094 / Alexion Pharmaceuticals, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc. Call
US0153511094 / Alexion Pharmaceuticals, Inc. Put
LUMO / Lumos Pharma, Inc.
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
ADVM / Adverum Biotechnologies, Inc. Call
ADVM / Adverum Biotechnologies, Inc. Put
CYH / Community Health Systems, Inc. Call
OPK / OPKO Health, Inc. Call
OPK / OPKO Health, Inc. Put
ANIP / ANI Pharmaceuticals, Inc. Call
CYTR / LadRx Corp Put
NWBO / Northwest Biotherapeutics, Inc. Put
RPTP / Raptor Pharmaceutical Corp. Call
RPTP / Raptor Pharmaceutical Corp. Put
IDRA / Idera Pharmaceuticals, Inc.
IDRA / Idera Pharmaceuticals, Inc. Put
607355906 / China Mobile Ltd. Call
ESPR / Esperion Therapeutics, Inc.
ESPR / Esperion Therapeutics, Inc. Put
SIOX / Sio Gene Therapies Inc.
CASI / CASI Pharmaceuticals, Inc.
ENDP / Endo International plc
HALO / Halozyme Therapeutics, Inc. Call
HALO / Halozyme Therapeutics, Inc. Put
ENDP / Endo International plc Put
BMRN / BioMarin Pharmaceutical Inc. Call
ZSPH / ZS Pharma, Inc.
ZSPH / ZS Pharma, Inc. Put
ANTH / Anthera Pharmaceuticals, Inc. Call
MDGN.WS / Medgenics, Inc., Warrant
NHWK / NightHawk Biosciences, Inc.
REEMF / Rare Element Resources Ltd.
MNKKQ / Mallinckrodt Plc Put
GILD / Gilead Sciences, Inc.
PCRX / Pacira BioSciences, Inc.
CLDX / Celldex Therapeutics, Inc. Call
CLDX / Celldex Therapeutics, Inc. Put
APDNW / Applied DNA Sciences, Inc., Warrants
US00C4U1L353 / Mylan N.V.
ONCE / Spark Therapeutics, Inc. Call
ARDX / Ardelyx, Inc.
ALNY / Alnylam Pharmaceuticals, Inc.
ALNY / Alnylam Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Put
DXTR / Dextera Surgical Inc.
91911K102 / Bausch Health Companies Put
KPRX / Kiora Pharmaceuticals, Inc.
ONCS / OncoSec Medical Inc
RCPT / Receptos, Inc. Call
RCPT / Receptos, Inc. Put
MBLY / Mobileye Global Inc.
MBLY / Mobileye Global Inc. Call
ACRX / Talphera, Inc. Put
TLT / iShares Trust - iShares 20+ Year Treasury Bond ETF
SESN / Sesen Bio Inc.
LJPC / La Jolla Pharmaceutical Co.
SPDR SERIES TRUST / S&P BIOTECH Put (78464A950)
MBLY / Mobileye Global Inc. Put
BCS / Barclays PLC - Depositary Receipt (Common Stock) Call
NVRO / Nevro Corp.
PRGO / Perrigo Company plc Call
ITP / IT Tech Packaging, Inc. Put
FWP / Forward Pharma A/S - ADR
FLDM / Standard BioTools Inc Call
ONCE / Spark Therapeutics, Inc. Put
CYNA / Cynapsus Therapeutics Inc.
COLLABRX ORD SHS / (19422J108)
91911K102 / Bausch Health Companies
NUVA / Nuvasive Inc
EXAS / Exact Sciences Corporation
HTWR / Heartware International Inc. Put
EXAS / Exact Sciences Corporation Call
US88165N2045 / Tetraphase Pharmaceuticals, Inc.
15117F112 / Cellectar Biosciences, Inc. Series A Warrants
CAPR / Capricor Therapeutics, Inc.
ATRS / Antares Pharma Inc Call
PVCT / Provectus Biopharmaceuticals, Inc.
MACK / Merrimack Pharmaceuticals, Inc. Call
CSLT / Castlight Health Inc - Class B Call
584688AC9 / Medicines Company 1.375% Bond due 2017-06-01
NXTM / NxStage Medical, Inc.
CSBR / Champions Oncology, Inc.
NONOF / Novo Nordisk A/S Put
MDCO / Medicines Company Put
FOLD / Amicus Therapeutics, Inc. Put
KITE / Kite Pharma, Inc. Put
IOC / InterOil Corporation Put
XOM / Exxon Mobil Corporation
CVMW / CEL-SCI Corp. Warrants
HTWR / Heartware International Inc.
IOVA / Iovance Biotherapeutics, Inc.
OCAT / Ocata Therapeutics, Inc.
TRUP / Trupanion, Inc.
ACERW / Acer Therapeutics Inc. Warrant
QRHC / Quest Resource Holding Corporation
HUM / Humana Inc. Call
BNTC / Benitec Biopharma Inc.
ONVO / Organovo Holdings, Inc.
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
0PP / Portola Pharmaceuticals Inc Put
ALPN / Alpine Immune Sciences, Inc.
RGLS / Regulus Therapeutics Inc.
FNCX / Function(x) Inc.
IMDZ / Immune Design Corp.
ECYT / Endocyte, Inc.
US60877T1007 / Momenta Pharmaceuticals, Inc.
IOC / InterOil Corporation
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
KERX / Keryx Biopharmaceuticals, Inc. Put
BMRN / BioMarin Pharmaceutical Inc.
NSPH / Nanosphere, Inc.
ZGNX / Zogenix Inc
ZGNX / Zogenix Inc Call
MLNT / Melinta Therapeutics, Inc.
IPCI / Intellipharmaceutics International Inc. Put
885175307 / Thoratec Put
XNPT / XenoPort, Inc. Call
HZNP / Horizon Therapeutics Plc Put
NLTX / Neoleukin Therapeutics, Inc.
KITE / Kite Pharma, Inc.
BMRN / BioMarin Pharmaceutical Inc. Put
FLDM / Standard BioTools Inc
PRSNW / Perseon Corporation Warrants
AERI / Aerie Pharmaceuticals Inc Call
PGNX / Progenics Pharmaceuticals, Inc. Put
GMED / Globus Medical, Inc.
ITCI / Intra-Cellular Therapies, Inc. Call
76028H209 / Repros Therapeutics, Inc.
ZLTQ / ZELTIQ Aesthetics, Inc.
RGLS / Regulus Therapeutics Inc. Call
VASC / Vascular Solutions, Inc.
TTHI / Transition Therapeutics Inc.
IL0011177958 / Intec Pharma Ltd
NTRA / Natera, Inc.
ENDP / Endo International plc Call
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
AR / Antero Resources Corporation
ATRS / Antares Pharma Inc
TROV / TrovaGene, Inc.
POZN / Pozen, Inc.
US60877T1007 / Momenta Pharmaceuticals, Inc. Call
DERM / Journey Medical Corporation
CEMP / Cempra, Inc. Call
MNOV / MediciNova, Inc.
09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018
US00C4U1L353 / Mylan N.V. Put
HZNP / Horizon Therapeutics Plc
FOLD / Amicus Therapeutics, Inc. Call
ZSPH / ZS Pharma, Inc. Call
US00C4U1L353 / Mylan N.V. Call
US00484MAA45 / Acorda Therapeutics, Inc. Bond 1.750% 6/1
032420101 / Anacor Pharmaceuticals, Inc.
885175307 / Thoratec Call
CHRS / Coherus Oncology, Inc.
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
PGNX / Progenics Pharmaceuticals, Inc.
PGNX / Progenics Pharmaceuticals, Inc. Call
IDRA / Idera Pharmaceuticals, Inc. Call
OCRX / Ocera Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc. Call
76028H209 / Repros Therapeutics, Inc. Put
032420101 / Anacor Pharmaceuticals, Inc. Call
MGNX / MacroGenics, Inc. Call
APEN / Apollo Endosurgery Inc
ABEO / Abeona Therapeutics Inc.
451731103 / Ignyta, Inc.
PRTK / Paratek Pharmaceuticals Inc.
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc. Call
REGN / Regeneron Pharmaceuticals, Inc. Put
RDUS / Radius Recycling, Inc.
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RDUS / Radius Recycling, Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc. Put
RMTI / Rockwell Medical, Inc.
RMTI / Rockwell Medical, Inc. Put
MNKKQ / Mallinckrodt Plc
XLB / The Select Sector SPDR Trust - The Materials Select Sector SPDR Fund Put
PXD / Pioneer Natural Resources Company
PXD / Pioneer Natural Resources Company Put
ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock)
09074D103 / Biotie Therapies Corp.
VXX / iPath Series B S&P 500 VIX Short-Term Futures ETN
VXX / iPath Series B S&P 500 VIX Short-Term Futures ETN Call
OCUL / Ocular Therapeutix, Inc.
OCUL / Ocular Therapeutix, Inc. Call
ASRT / Assertio Holdings, Inc.
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Call
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Put
ASRT / Assertio Holdings, Inc. Call
VASC / Vascular Solutions, Inc. Put
HTWR / Heartware International Inc. Call
ZSAN / Zosano Pharma Corp
AM / Antero Midstream Corporation Call
NVAX / Novavax, Inc. Call
/ GW Pharmaceuticals Plc. Put
/ GW Pharmaceuticals Plc. Call
FGEN / FibroGen, Inc.
SRPT / Sarepta Therapeutics, Inc. Call
CBPO / China Biologic Products Holdings Inc
PEGY / Pineapple Energy Inc. Call
RIBT / RiceBran Technologies
CJJD / China Jo-Jo Drugstores, Inc.
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc. Put
DYAX / Dyax Corp.
DYAX / Dyax Corp. Put
BCLI / Brainstorm Cell Therapeutics Inc.
CYCC / Cyclacel Pharmaceuticals, Inc.
DYAX / Dyax Corp. Call
ALDX / Aldeyra Therapeutics, Inc.
TENX / Tenax Therapeutics, Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Call
INO / Inovio Pharmaceuticals, Inc. Call
XOM / Exxon Mobil Corporation Put
TPST / Tempest Therapeutics, Inc. Call
TPST / Tempest Therapeutics, Inc. Put
NVAX / Novavax, Inc. Put
MCRB / Seres Therapeutics, Inc.
ASXC / Asensus Surgical, Inc.
HIFR / InfraREIT, Inc. Call
LRMR / Larimar Therapeutics, Inc. Put
ACRX / Talphera, Inc.
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Put
PIRS / Pieris Pharmaceuticals, Inc.
GNCA / Genocea Biosciences Inc
ADMS / Adamas Pharmaceuticals Inc
BLPH / Bellerophon Therapeutics, Inc.
IMUC / EOM Pharmaceuticals Holdings, Inc.
TXMD / TherapeuticsMD, Inc. Call
CDTX / Cidara Therapeutics, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Put
NURO / NeuroMetrix, Inc.
VRTX / Vertex Pharmaceuticals Incorporated
MEIP / MEI Pharma, Inc.
0PP / Portola Pharmaceuticals Inc
XOMA / XOMA Royalty Corporation Call
XOMA / XOMA Royalty Corporation Put
INFI / Infinity Pharmaceuticals Inc.
INFI / Infinity Pharmaceuticals Inc. Call
INFI / Infinity Pharmaceuticals Inc. Put
ASXC / Asensus Surgical, Inc. Call
CYTK / Cytokinetics, Incorporated Call
CYTK / Cytokinetics, Incorporated Put
US0325111070 / Anadarko Petroleum Corp.
US0325111070 / Anadarko Petroleum Corp. Put
US0325111070 / Anadarko Petroleum Corp. Call
ISEE / IVERIC bio Inc Call
BCRX / BioCryst Pharmaceuticals, Inc.
BCRX / BioCryst Pharmaceuticals, Inc. Call
BCRX / BioCryst Pharmaceuticals, Inc. Put
GBT / Global Blood Therapeutics Inc.
BLCM / Bellicum Pharmaceuticals, Inc.
EW / Edwards Lifesciences Corporation
AMG / Affiliated Managers Group, Inc. Put
TNXP / Tonix Pharmaceuticals Holding Corp.
PBYI / Puma Biotechnology, Inc. Put
TSRO / TESARO, Inc.
TSRO / TESARO, Inc. Call
PGEN / Precigen, Inc. Put
PGEN / Precigen, Inc. Call
GILD / Gilead Sciences, Inc. Call
GILD / Gilead Sciences, Inc. Put
DBVT / DBV Technologies S.A. - Depositary Receipt (Common Stock)
HCA / HCA Healthcare, Inc. Call
HCA / HCA Healthcare, Inc. Put
EW / Edwards Lifesciences Corporation Put
LLY / Eli Lilly and Company Call
LLY / Eli Lilly and Company Put
BIIB / Biogen Inc.
BIIB / Biogen Inc. Put
BIIB / Biogen Inc. Call
OCGN / Ocugen, Inc.
ABBV / AbbVie Inc.
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
CLBS / Caladrius Biosciences Inc
SPY / SPDR S&P 500 ETF Put
PSTI / Pluristem Therapeutics Inc Put
AGTC / Applied Genetic Technologies Corp
INO / Inovio Pharmaceuticals, Inc.
PSTI / Pluristem Therapeutics Inc
NVIV / InVivo Therapeutics Holdings Corp. Call
THC / Tenet Healthcare Corporation
THC / Tenet Healthcare Corporation Call
THC / Tenet Healthcare Corporation Put
MRTX / Mirati Therapeutics, Inc.
NSPR / InspireMD, Inc.
KPRX / Kiora Pharmaceuticals, Inc.
CTIC / CTI BioPharma Corp Call
TTOO / T2 Biosystems, Inc.
OPK / OPKO Health, Inc.
ALQA / Alliqua, Inc.
ACUR / Acura Pharmaceuticals, Inc.
HCMC / Healthier Choices Management Corp.
IMUX / Immunic, Inc. Call
ORMP / Oramed Pharmaceuticals Inc.
IMUX / Immunic, Inc. Put
CLSN / Imunon Inc Put
AAPL / Apple Inc. Call
OMER / Omeros Corporation
OMER / Omeros Corporation Call
LXRX / Lexicon Pharmaceuticals, Inc.
LXRX / Lexicon Pharmaceuticals, Inc. Call
LXRX / Lexicon Pharmaceuticals, Inc. Put
VTVT / vTv Therapeutics Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
BLUE / bluebird bio, Inc. Put
BLUE / bluebird bio, Inc. Call
IMUX / Immunic, Inc.
RVNC / Revance Therapeutics, Inc. Call
BPTH / Bio-Path Holdings, Inc.
SKBI / Skystar Bio-Pharmaceutical Company
RSLS / ReShape Lifesciences Inc.
NBSE / NeuBase Therapeutics, Inc.
TENX / Tenax Therapeutics, Inc.
CYH / Community Health Systems, Inc.
CYH / Community Health Systems, Inc. Put
ATHX / Athersys, Inc. Put
HRTX / Heron Therapeutics, Inc.
HRTX / Heron Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
BIOL / BIOLASE, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
CDMO / Avid Bioservices, Inc.
NVRO / Nevro Corp. Call
NVRO / Nevro Corp. Put
RCKT / Rocket Pharmaceuticals, Inc.
BPMC / Blueprint Medicines Corporation
SAGE / Sage Therapeutics, Inc.
SAGE / Sage Therapeutics, Inc. Call
PTCT / PTC Therapeutics, Inc. Call
PTCT / PTC Therapeutics, Inc. Put
PTCT / PTC Therapeutics, Inc.
CBAY / CymaBay Therapeutics, Inc.
ALKS / Alkermes plc Call
VIRX / Viracta Therapeutics, Inc.
VIRX / Viracta Therapeutics, Inc. Put
SLS / SELLAS Life Sciences Group, Inc. Put
CLRB / Cellectar Biosciences, Inc.
ELDN / Eledon Pharmaceuticals, Inc.
SSKN / STRATA Skin Sciences, Inc.
LRMR / Larimar Therapeutics, Inc. Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
AFMD / Affimed N.V.
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
NWBO / Northwest Biotherapeutics, Inc.
LPCN / Lipocine Inc.
DVAX / Dynavax Technologies Corporation Put
DVAX / Dynavax Technologies Corporation
DVAX / Dynavax Technologies Corporation Call
XTLB / XTL Biopharmaceuticals Ltd. - Depositary Receipt (Common Stock)
MBOT / Microbot Medical Inc.
APDN / Applied DNA Sciences, Inc.
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
TPST / Tempest Therapeutics, Inc.
SRNE / Sorrento Therapeutics, Inc. Call
SRNE / Sorrento Therapeutics, Inc.
SEEL / Seelos Therapeutics, Inc. Put
NURO / NeuroMetrix, Inc.
ATNM / Actinium Pharmaceuticals, Inc.
CLSN / Imunon Inc
SEEL / Seelos Therapeutics, Inc.
GEVO * / Gevo, Inc.
ACRX / Talphera, Inc. Call
IWM / iShares Trust - iShares Russell 2000 ETF