Market Value1,916,583,000
Total Holdings287
File Date2016-08-15
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price		 Prev
Shares		 Current
Shares		 Change
(Percent)		 Prev Value
(USD x1000)		 Current Value
(USD x1000)		 Change
(Percent)
AEZS / COSCIENS Biopharma Inc.
ADVM / Adverum Biotechnologies, Inc.
GWP / GW Pharmaceuticals plc
NVAX / Novavax, Inc.
NVAX / Novavax, Inc. Call
INSM / Insmed Incorporated
ATRS / Antares Pharma Inc
ATRS / Antares Pharma Inc Call
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated Put
CYTR / LadRx Corp Call
SCON / Superconductor Technologies Inc.
CYTK / Cytokinetics, Incorporated Call
MTEM / Molecular Templates, Inc.
ARLZ / Aralez Pharmaceuticals Inc. Call
EXEL / Exelixis, Inc. Call
NWBO / Northwest Biotherapeutics, Inc. Put
WINT / Windtree Therapeutics, Inc.
ICPT / Intercept Pharmaceuticals Inc Put
ILMN / Illumina, Inc.
ALQA / Alliqua, Inc.
COLL / Collegium Pharmaceutical, Inc.
MDCO / Medicines Company
RIGL / Rigel Pharmaceuticals, Inc. Call
EXPR / Express, Inc. Put
TSRO / TESARO, Inc. Call
878193101 / TearLab Corp
IOVA / Iovance Biotherapeutics, Inc. Put
EXPR / Express, Inc.
WGBS / WaferGen Bio-Systems, Inc.
JUNO / Juno Therapeutics, Inc. Call
PATI / Patriot Transportation Holding, Inc.
CSBR / Champions Oncology, Inc.
IOVA / Iovance Biotherapeutics, Inc.
SHPG / Shire Plc. Put
ADXS / Ayala Pharmaceuticals, Inc. Call
TRIL / Trillium Therapeutics Inc
UTHR / United Therapeutics Corporation Call
BDSI / Biodelivery Sciences International
BDSI / Biodelivery Sciences International Call
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
ATHX / Athersys, Inc. Put
THMO / ThermoGenesis Holdings, Inc.
MDVN / Medivation, Inc.
ADMS / Adamas Pharmaceuticals Inc
RLYP / Relypsa, Inc.
LUMO / Lumos Pharma, Inc.
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
ADVM / Adverum Biotechnologies, Inc. Call
ZSAN / Zosano Pharma Corp
CASC / Cascadian Therapeutics, Inc.
POAI / Predictive Oncology Inc.
OPK / OPKO Health, Inc.
ENDP / Endo International plc
TROV / TrovaGene, Inc.
LRMR / Larimar Therapeutics, Inc. Call
IL0011177958 / Intec Pharma Ltd
SESN / Sesen Bio Inc.
XLRN / Acceleron Pharma Inc
CMRX / Chimerix, Inc.
SIOX / Sio Gene Therapies Inc.
EW / Edwards Lifesciences Corporation Put
HALO / Halozyme Therapeutics, Inc.
HALO / Halozyme Therapeutics, Inc. Call
ONCS / OncoSec Medical Inc
KPRX / Kiora Pharmaceuticals, Inc.
VTVT / vTv Therapeutics Inc.
PPBT / Purple Biotech Ltd - Depositary Receipt (Common Stock)
OPGN / OpGen, Inc.
61166W101 / Monsanto Co. Call
EW / Edwards Lifesciences Corporation Call
RNVA / Rennova Health, Inc.
ABT / Abbott Laboratories
ABT / Abbott Laboratories Call
ABT / Abbott Laboratories Put
FOLD / Amicus Therapeutics, Inc. Call
FOLD / Amicus Therapeutics, Inc. Put
MDCO / Medicines Company Call
MDCO / Medicines Company Put
ALNY / Alnylam Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Put
VNDA / Vanda Pharmaceuticals Inc. Call
91911K102 / Bausch Health Companies Call
CLVS / Clovis Oncology Inc Call
MDVN / Medivation, Inc. Put
TENX / Tenax Therapeutics, Inc. Call
TENX / Tenax Therapeutics, Inc. Put
032420101 / Anacor Pharmaceuticals, Inc. Call
92686J114 / Viking Therapeutics, Inc. Warrants exp. 2021-04-04
GNMX / Aevi Genomic Medicine, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc. Put
ACAD / ACADIA Pharmaceuticals Inc.
ITCI / Intra-Cellular Therapies, Inc.
ITCI / Intra-Cellular Therapies, Inc. Call
ITCI / Intra-Cellular Therapies, Inc. Put
ADHD / Alcobra Ltd. Call
ALPN / Alpine Immune Sciences, Inc.
BIIB / Biogen Inc. Call
ABUS / Arbutus Biopharma Corporation
ABUS / Arbutus Biopharma Corporation Call
PARN / Parnell Pharmaceuticals Holdings Ltd.
RLYP / Relypsa, Inc. Call
DERM / Journey Medical Corporation Put
ALDX / Aldeyra Therapeutics, Inc.
ARCT / Arcturus Therapeutics Holdings Inc.
PVCT / Provectus Biopharmaceuticals, Inc.
NTRA / Natera, Inc.
ARQL / ArQule, Inc.
OMER / Omeros Corporation Call
FLDM / Standard BioTools Inc
AKRX / Akorn, Inc. Put
/ Ceres, Inc.
CYTX / Cytori Therapeutics, Inc.
CRDC / Cardica, Inc.
NTRA / Natera, Inc. Call
SHPG / Shire Plc. Call
CYTXW / Cytori Therapeutics, Inc. Warrants
ONSIW / Oncobiologics, Inc. Series A Warrant Expiring 2/18/2018
RIGL / Rigel Pharmaceuticals, Inc.
STAF / Staffing 360 Solutions, Inc.
220480AB3 / Amrn 3.5 1/32 Bond
RENNOVA HEALTH INC / *W (759757115)
LJPC / La Jolla Pharmaceutical Co. Call
US60877T1007 / Momenta Pharmaceuticals, Inc. Put
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
HZNP / Horizon Therapeutics Plc Call
HZNP / Horizon Therapeutics Plc Put
NSPH / Nanosphere, Inc.
/ Immunomedics, Inc.
ZGNX / Zogenix Inc
ZGNX / Zogenix Inc Call
CBMX / CombiMatrix Corp.
CBMX / CombiMatrix Corp.
MLNT / Melinta Therapeutics, Inc.
OASM / Oasmia Pharmaceutical AB
EIGR / Eiger BioPharmaceuticals, Inc.
RGLS / Regulus Therapeutics Inc. Call
US60877T1007 / Momenta Pharmaceuticals, Inc.
49803V115 / Kitov Pharamceuticals Holdings Ltd.
RGNX / REGENXBIO Inc.
SPDR S&P 500 BIOTECH / TR Put (78464A950)
OCX / OncoCyte Corporation
ACOR / Acorda Therapeutics, Inc. Put
GNVC / GenVec, Inc.
NERV / Minerva Neurosciences, Inc.
DERM / Journey Medical Corporation Call
CYNA / Cynapsus Therapeutics Inc.
RGLS / Regulus Therapeutics Inc.
PSDV / pSivida Corp.
ELDN / Eledon Pharmaceuticals, Inc.
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
SPNC / Spectranetics Corp. (The) Call
NXTM / NxStage Medical, Inc. Put
TBRA / Tobira Therapeutics, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
FOMX / Foamix Pharmaceuticals Ltd.
AKRX / Akorn, Inc.
AKRX / Akorn, Inc. Call
PRSNW / Perseon Corporation Warrants
BNTCW / Benitec Biopharma Ltd
HTWR / Heartware International Inc. Put
RLYP / Relypsa, Inc. Put
ACRS / Aclaris Therapeutics, Inc.
PGNX / Progenics Pharmaceuticals, Inc.
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019
ANTH / Anthera Pharmaceuticals, Inc.
ONSIZ / Oncobiologics, Inc. Series B Warrant Expiring 5/18
FWP / Forward Pharma A/S - ADR
FOLD / Amicus Therapeutics, Inc.
OCRX / Ocera Therapeutics, Inc.
CLRBW / Cellectar Biosciences, Inc. Warrants expiring 8/20/2019
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019 Call
LJPC / La Jolla Pharmaceutical Co.
IMUC / EOM Pharmaceuticals Holdings, Inc.
QRHC / Quest Resource Holding Corporation
VXX / iPath Series B S&P 500 VIX Short-Term Futures ETN Call
SRRA / Sierra Oncology Inc
SVRA / Savara Inc. Put
AERI / Aerie Pharmaceuticals Inc Call
KITE / Kite Pharma, Inc. Call
US60877T1007 / Momenta Pharmaceuticals, Inc. Call
SCYX / SCYNEXIS, Inc.
NUROW / NeuroMetrix, Inc. Warrants
ADHD / Alcobra Ltd. Put
SHPG / Shire Plc.
PGNX / Progenics Pharmaceuticals, Inc. Put
CEMP / Cempra, Inc. Call
CEMP / Cempra, Inc. Put
ARLZ / Aralez Pharmaceuticals Inc.
EGRX / Eagle Pharmaceuticals, Inc.
US00C4U1L353 / Mylan N.V. Call
ADMA / ADMA Biologics, Inc.
ACERW / Acer Therapeutics Inc. Warrant
032420101 / Anacor Pharmaceuticals, Inc.
RGLS / Regulus Therapeutics Inc. Put
US00484MAA45 / Acorda Therapeutics, Inc. Bond 1.750% 6/1
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
ANTH / Anthera Pharmaceuticals, Inc. Call
PGNX / Progenics Pharmaceuticals, Inc. Call
MDGN.WS / Medgenics, Inc., Warrant
ONTY / Oncothyreon, Inc.
451731103 / Ignyta, Inc.
APEN / Apollo Endosurgery Inc
PRTK / Paratek Pharmaceuticals Inc.
PRTK / Paratek Pharmaceuticals Inc. Call
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc. Call
REGN / Regeneron Pharmaceuticals, Inc. Put
BNTC / Benitec Biopharma Inc.
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RDUS / Radius Recycling, Inc. Call
RDUS / Radius Recycling, Inc. Put
RDUS / Radius Recycling, Inc.
CLRB / Cellectar Biosciences, Inc.
NVAX / Novavax, Inc. Put
LNKD / LinkedIn Corp. Call
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Call
ASRT / Assertio Holdings, Inc. Call
ASRT / Assertio Holdings, Inc.
ALBO / Albireo Pharma Inc
/ GW Pharmaceuticals Plc. Put
/ GW Pharmaceuticals Plc. Call
FGEN / FibroGen, Inc.
PRTA / Prothena Corporation plc
CGRN / Capstone Green Energy Corp.
VRTX / Vertex Pharmaceuticals Incorporated
VRTX / Vertex Pharmaceuticals Incorporated Put
KPRX / Kiora Pharmaceuticals, Inc.
SRPT / Sarepta Therapeutics, Inc.
GALT / Galectin Therapeutics Inc.
KDNY / Chinook Therapeutics Inc Call
CAPR / Capricor Therapeutics, Inc.
RIBT / RiceBran Technologies
NSPR / InspireMD, Inc.
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
US0153511094 / Alexion Pharmaceuticals, Inc.
CYCC / Cyclacel Pharmaceuticals, Inc.
MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF
DERM / Journey Medical Corporation
ALKS / Alkermes plc
IPCI / Intellipharmaceutics International Inc. Put
CBAY / CymaBay Therapeutics, Inc.
ABEO / Abeona Therapeutics Inc.
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL
MCRB / Seres Therapeutics, Inc.
MCRB / Seres Therapeutics, Inc. Call
CELG / Celgene Corp. Call
CELG / Celgene Corp. Put
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Put
DRRX / DURECT Corporation
DRRX / DURECT Corporation Call
PIRS / Pieris Pharmaceuticals, Inc.
GLD / SPDR Gold Trust Call
PFE / Pfizer Inc. Call
TXMD / TherapeuticsMD, Inc.
TXMD / TherapeuticsMD, Inc. Call
TXMD / TherapeuticsMD, Inc. Put
CDTX / Cidara Therapeutics, Inc.
SENS / Senseonics Holdings, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Call
AKBA / Akebia Therapeutics, Inc. Call
OTIC / Otonomy Inc
ESRX / Express Scripts Holding Co. Put
0PP / Portola Pharmaceuticals Inc Call
INFI / Infinity Pharmaceuticals Inc.
INFI / Infinity Pharmaceuticals Inc. Put
PGEN / Precigen, Inc.
ASXC / Asensus Surgical, Inc. Call
ARMP / Armata Pharmaceuticals, Inc.
AMGN / Amgen Inc. Put
AMGN / Amgen Inc.
ISEE / IVERIC bio Inc Call
ACUR / Acura Pharmaceuticals, Inc.
INFI / Infinity Pharmaceuticals Inc. Call
GBT / Global Blood Therapeutics Inc.
GBT / Global Blood Therapeutics Inc. Call
ALQA / Alliqua, Inc. Call
SLS / SELLAS Life Sciences Group, Inc.
ASXC / Asensus Surgical, Inc. Put
ESRX / Express Scripts Holding Co.
BLCM / Bellicum Pharmaceuticals, Inc.
JNJ / Johnson & Johnson Call
JNJ / Johnson & Johnson Put
TNXP / Tonix Pharmaceuticals Holding Corp.
PBYI / Puma Biotechnology, Inc. Call
PGEN / Precigen, Inc. Put
NVIV / InVivo Therapeutics Holdings Corp.
DBVT / DBV Technologies S.A. - Depositary Receipt (Common Stock)
HCA / HCA Healthcare, Inc. Call
HCA / HCA Healthcare, Inc. Put
ASMB / Assembly Biosciences, Inc.
BIIB / Biogen Inc.
BIIB / Biogen Inc. Put
IONS / Ionis Pharmaceuticals, Inc. Call
IONS / Ionis Pharmaceuticals, Inc.
IONS / Ionis Pharmaceuticals, Inc. Put
EGRX / Eagle Pharmaceuticals, Inc. Call
EGRX / Eagle Pharmaceuticals, Inc. Put
OCGN / Ocugen, Inc.
VYNT / Vyant Bio, Inc.
CLVS / Clovis Oncology Inc
CLVS / Clovis Oncology Inc Put
SSKN / STRATA Skin Sciences, Inc.
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
GILD / Gilead Sciences, Inc. Put
BCLI / Brainstorm Cell Therapeutics Inc.
GILD / Gilead Sciences, Inc. Call
PSTI / Pluristem Therapeutics Inc
FLXN / Horizon Funds - Horizon Flexible Income ETF
THC / Tenet Healthcare Corporation Call
OTLK / Outlook Therapeutics, Inc.
TTOO / T2 Biosystems, Inc.
MRTX / Mirati Therapeutics, Inc.
OPK / OPKO Health, Inc. Call
OPK / OPKO Health, Inc. Put
VTGN / Vistagen Therapeutics, Inc.
NHWK / NightHawk Biosciences, Inc.
PALI / Palisade Bio, Inc.
NVIV / InVivo Therapeutics Holdings Corp. Call
AKTX / Akari Therapeutics, Plc - Depositary Receipt (Common Stock)
PRQR / ProQR Therapeutics N.V.
LXRX / Lexicon Pharmaceuticals, Inc. Call
LXRX / Lexicon Pharmaceuticals, Inc. Put
TVTX / Travere Therapeutics, Inc. Call
TVTX / Travere Therapeutics, Inc. Put
TVTX / Travere Therapeutics, Inc.
OCUP / Opus Genetics, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
RVNC / Revance Therapeutics, Inc. Call
ARDX / Ardelyx, Inc.
BPTH / Bio-Path Holdings, Inc.
SLNO / Soleno Therapeutics, Inc.
TENX / Tenax Therapeutics, Inc.
ATHX / Athersys, Inc.
HRTX / Heron Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
TMBR / Timber Pharmaceuticals Inc
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
DXCM / DexCom, Inc. Call
DXCM / DexCom, Inc. Put
RCKT / Rocket Pharmaceuticals, Inc.
BPMC / Blueprint Medicines Corporation
BPMC / Blueprint Medicines Corporation Call
SAGE / Sage Therapeutics, Inc.
SAGE / Sage Therapeutics, Inc. Call
SAGE / Sage Therapeutics, Inc. Put
PTCT / PTC Therapeutics, Inc. Call
ALKS / Alkermes plc Call
SLS / SELLAS Life Sciences Group, Inc. Put
ENLV / Enlivex Therapeutics Ltd.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
NBIX / Neurocrine Biosciences, Inc.
NBIX / Neurocrine Biosciences, Inc. Call
LPCN / Lipocine Inc.
LPCN / Lipocine Inc. Call
DVAX / Dynavax Technologies Corporation
DVAX / Dynavax Technologies Corporation Call
DVAX / Dynavax Technologies Corporation Put
XTLB / XTL Biopharmaceuticals Ltd. - Depositary Receipt (Common Stock)
TPST / Tempest Therapeutics, Inc.
NWBO / Northwest Biotherapeutics, Inc.
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
SRNE / Sorrento Therapeutics, Inc.
BCLI / Brainstorm Cell Therapeutics Inc. Call
NURO / NeuroMetrix, Inc.
CLSN / Imunon Inc
CVM / CEL-SCI Corporation
TNXP / Tonix Pharmaceuticals Holding Corp. Call
ADXS / Ayala Pharmaceuticals, Inc. Put
ADXS / Ayala Pharmaceuticals, Inc.
LLY / Eli Lilly and Company Call
LLY / Eli Lilly and Company Put
SPY / SPDR S&P 500 ETF
SPY / SPDR S&P 500 ETF Put
OEF / iShares Trust - iShares S&P 100 ETF Put