Clive Meanwell - Insider Trading Tracker

Fractyl Health, Inc.

US ˙ NasdaqGM

Pendahuluan

Halaman ini memberikan analisis komprehensif tentang sejarah perdagangan orang dalam yang diketahui dari Clive Meanwell. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Adalah ilegal bagi orang dalam untuk melakukan perdagangan di perusahaan mereka berdasarkan informasi spesifik yang tidak dipublikasikan. Ini tidak berarti bahwa mereka dilarang melakukan perdagangan apa pun di perusahaan mereka sendiri. Namun, mereka harus melaporkan semua perdagangan kepada SEC melalui Formulir 4. Terlepas dari pembatasan ini, penelitian akademis menunjukkan bahwa orang dalam - secara umum - cenderung mengungguli pasar di perusahaan mereka sendiri.

Rata-rata Profitabilitas Perdagangan

Profitabilitas perdagangan rata-rata adalah pengembalian rata-rata dari semua pembelian pasar terbuka yang dilakukan oleh orang dalam dalam tiga tahun terakhir. Untuk menghitung ini, kami memeriksa setiap pembelian pasar terbuka yang tidak direncanakan yang dilakukan oleh orang dalam, tidak termasuk semua perdagangan yang ditandai sebagai bagian dari rencana perdagangan 10b5-1. Kami kemudian menghitung kinerja rata-rata dari perdagangan tersebut selama 3, 6, dan 12 bulan, dengan merata-ratakan setiap durasi tersebut untuk menghasilkan metrik kinerja akhir untuk setiap perdagangan. Terakhir, kami merata-ratakan semua metrik kinerja untuk menghitung metrik kinerja untuk orang dalam. Daftar ini hanya mencakup orang dalam yang telah melakukan setidaknya tiga perdagangan dalam dua tahun terakhir.

Jika profitabilitas perdagangan orang dalam ini adalah "N/A", maka orang dalam tersebut belum melakukan pembelian di pasar terbuka dalam tiga tahun terakhir, atau perdagangan yang mereka lakukan terlalu baru untuk menghitung metrik kinerja yang andal.

Frekuensi Pembaruan: Setiap Hari

Lihat daftar pedagang dalam perusahaan yang paling menguntungkan.

Lihat Peringkat Tertinggi Orang Dalam

Perusahaan dengan Posisi Orang Dalam yang Dilaporkan

Pengajuan SEC menunjukkan bahwa Clive Meanwell telah melaporkan kepemilikan atau perdagangan di perusahaan-perusahaan berikut:

Keamanan	Judul	Kepemilikan Terakhir yang Dilaporkan
	Executive Chairman, Director, 10% Owner	12,767,462
US:GUTS / Fractyl Health, Inc.	Director	277,890
US:ADGI / Adagio Therapeutics Inc		1,201,680
US:EQRX / EQRx Inc	Director	42,946
US:PHIC / Population Health Investment Co Inc - Class A	Chief Executive Officer, Director	20,000
US:MDCO / Medicines Company	Chief Innovation Officer, Director	0

Cara Membaca Grafik

Grafik berikut menunjukkan kinerja saham sekuritas setelah setiap perdagangan pasar terbuka yang tidak direncanakan yang dilakukan oleh Clive Meanwell. Perdagangan yang tidak direncanakan adalah perdagangan yang tidak dilakukan sebagai bagian dari rencana perdagangan 10b5-1. Kinerja saham digambarkan sebagai perubahan persentase kumulatif dalam harga saham. Misalnya, jika perdagangan orang dalam dilakukan pada 1 Januari 2019, grafik akan menunjukkan perubahan persentase harian sekuritas hingga saat ini. Jika harga saham naik dari $10 menjadi $15 selama periode ini, perubahan persentase kumulatif dalam harga saham akan menjadi 50%. Perubahan harga dari $10 menjadi $20 akan menjadi 100%, dan perubahan harga dari $10 menjadi $5 akan menjadi -50%.

Pada akhirnya, kita mencoba menentukan seberapa erat korelasi perdagangan orang dalam dengan pengembalian berlebih (positif atau negatif) pada harga saham untuk melihat apakah orang dalam tersebut mengatur waktu perdagangannya untuk mendapatkan keuntungan dari informasi orang dalam. Pertimbangkan situasi di mana orang dalam melakukan hal ini. Dalam situasi ini, kita akan mengharapkan (a) pengembalian positif setelah pembelian, atau (b) pengembalian negatif setelah penjualan. Dalam kasus (a), grafik PEMBELIAN akan menunjukkan serangkaian kurva yang miring ke atas, menunjukkan pengembalian positif setelah setiap transaksi pembelian. Dalam kasus (b), grafik PENJUALAN akan menunjukkan serangkaian kurva yang miring ke bawah, menunjukkan pengembalian negatif setelah setiap transaksi penjualan.

Namun, ini saja tidak cukup untuk menarik kesimpulan. Jika, misalnya, harga saham perusahaan berada dalam tren kenaikan non-siklikal selama bertahun-tahun, maka kita akan mengharapkan semua plot pasca-pembelian memiliki kemiringan ke atas. Demikian pula, penurunan non-siklikal selama bertahun-tahun akan menghasilkan plot pasca-perdagangan dengan kemiringan ke bawah. Tak satu pun dari grafik ini akan menunjukkan aktivitas perdagangan orang dalam.

Indikator terkuat adalah situasi di mana harga saham sangat siklikal, dan terdapat sinyal positif pada grafik PEMBELIAN dan plot negatif pada grafik PENJUALAN. Situasi ini akan sangat menunjukkan adanya orang dalam yang mengatur waktu perdagangan untuk keuntungan finansial mereka.

Pembelian Orang Dalam GUTS / Fractyl Health, Inc. - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di GUTS / Fractyl Health, Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Ticker	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Maksimal	Harga di Maksimal	Maksimal Keuntungan ($)	Maksimum Pengembalian (%)
Tidak ada transaksi pasar terbuka tak terduga yang diketahui untuk kombinasi orang dalam dan sekuritas ini.

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

Penjualan Orang Dalam GUTS / Fractyl Health, Inc. - Analisis Kerugian Jangka Pendek

Pada bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan internal pasar terbuka yang tidak direncanakan yang dilakukan di GUTS / Fractyl Health, Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham Dilaporkan
Harga Disesuaikan
Saham Disesuaikan
Harga Dasar Biaya Hari-hari menuju
Menit Harga di
Menit Kerugian Maksimal
Dihindari ($) Kerugian Maksimal
Dihindari (%)

Tidak ada transaksi pasar terbuka tak terduga yang diketahui untuk kombinasi orang dalam dan sekuritas ini.

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

Pembelian Orang Dalam IVVD / Invivyd, Inc. - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di GUTS / Fractyl Health, Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham Dilaporkan
Harga Disesuaikan
Saham Disesuaikan
Harga Dasar Biaya Hari-hari menuju
Maksimal Harga di
Maksimal Maksimal
Keuntungan ($) Maksimum Pengembalian (%)

Tidak ada transaksi pasar terbuka tak terduga yang diketahui untuk kombinasi orang dalam dan sekuritas ini.

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

Penjualan Orang Dalam IVVD / Invivyd, Inc. - Analisis Kerugian Jangka Pendek

Pada bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan internal pasar terbuka yang tidak direncanakan yang dilakukan di GUTS / Fractyl Health, Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham Dilaporkan
Harga Disesuaikan
Saham Disesuaikan
Harga Dasar Biaya Hari-hari menuju
Menit Harga di
Menit Kerugian Maksimal
Dihindari ($) Kerugian Maksimal
Dihindari (%)

Tidak ada transaksi pasar terbuka tak terduga yang diketahui untuk kombinasi orang dalam dan sekuritas ini.

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

Sejarah Perdagangan Orang Dalam

Tabel ini menunjukkan daftar lengkap transaksi orang dalam yang dilakukan oleh Clive Meanwell sebagaimana diungkapkan kepada Komisi Bursa Efek (Securities Exchange Commission/SEC).

Tanggal File Tanggal Transaksi Formulir Ticker Keamanan Kode 10b5-1 Saham Sisa Saham Persen
Ubah Bagikan
Harga Tran
Nilai Sisa
Nilai

2025-01-30 3 MTSR Metsera, Inc.
Common Stock 12,767,462

2024-02-08 2024-02-06 4 GUTS Fractyl Health, Inc.
Common Stock C - Conversion 277,890 277,890

2022-03-30 3 ADGI Adagio Therapeutics, Inc.
Common Stock 1,201,680

2021-12-20 2021-12-17 4 EQRX EQRx, Inc.
Earn-out Shares A - Award 42,946 42,946

2021-12-20 2021-12-17 4 EQRX EQRx, Inc.
Stock Option (Right to Buy) A - Award 313,500 313,500

2021-08-25 2021-08-24 4 PHIC Population Health Investment Co., Inc.
Warrants to purchase Class A Ordinary Share P - Purchase 20,000 20,000 0.79 15,800 15,800

2021-08-25 2021-08-24 4 PHIC Population Health Investment Co., Inc.
Class A Ordinary Shares P - Purchase 11,300 11,300 9.80 110,740 110,740

2021-08-25 2021-08-24 4 PHIC Population Health Investment Co., Inc.
Class A Ordinary Shares P - Purchase 5,100 16,400 45.13 9.79 49,929 160,556

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -95,000 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -117,000 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -117,000 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -234,000 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -87,750 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -210,793 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -297,776 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -234,375 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Stock Option D - Sale to Issuer -120,000 0 -100.00

2020-01-06 2020-01-06 4 MDCO MEDICINES CO /DE
Common Stock D - Sale to Issuer -480,340 0 -100.00

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Stock Option M - Exercise -11,483 120,000 -8.73

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Stock Option M - Exercise -64,568 0 -100.00

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Stock Option M - Exercise -150,000 0 -100.00

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Stock Option M - Exercise -240,000 0 -100.00

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Stock Option M - Exercise -15,620 0 -100.00

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Stock Option M - Exercise -60,000 0 -100.00

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -22,345 480,340 -4.45 84.78 -1,894,409 40,723,225

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -329,796 502,685 -39.62 84.78 -27,960,105 42,617,634

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 11,483 832,481 1.40 30.55 350,806 25,432,295

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 64,568 820,998 8.54 31.49 2,033,246 25,853,227

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 150,000 756,430 24.73 22.04 3,306,000 16,671,717

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 240,000 606,430 65.50 17.45 4,188,000 10,582,204

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 15,620 366,430 4.45 13.54 211,495 4,961,462

2019-12-31 2019-12-27 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 60,000 350,810 20.63 7.31 438,600 2,564,421

2019-09-04 2019-08-30 4 MDCO MEDICINES CO /DE
Common Stock A - Award 491 290,810 0.17 21.60 10,606 6,281,496

2019-04-26 2019-04-25 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -2,796 290,319 -0.95 30.48 -85,222 8,848,923

2019-03-06 2019-03-04 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -2,962 293,115 -1.00 25.53 -75,620 7,483,226

2019-03-06 2019-03-04 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -3,586 296,077 -1.20 25.53 -91,551 7,558,846

2019-03-06 2019-03-04 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -3,063 299,663 -1.01 25.53 -78,198 7,650,396

2019-03-04 2019-03-01 4 MDCO MEDICINES CO /DE
Stock option (right to buy) A - Award 95,000 95,000

2019-03-04 2019-02-28 4 MDCO MEDICINES CO /DE
Common Stock A - Award 317 302,726 0.10 20.97 6,647 6,348,164

2018-09-05 2018-09-04 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -50,000 302,409 -14.19 39.31 -1,965,500 11,887,698

2018-09-05 2018-08-31 4 MDCO MEDICINES CO /DE
Common Stock A - Award 375 352,409 0.11 28.28 10,605 9,966,127

2018-08-02 2018-08-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -50,000 352,034 -12.44 39.24 -1,962,000 13,813,814

2018-07-05 2018-07-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -50,000 402,034 -11.06 36.07 -1,803,500 14,501,366

2018-04-26 2018-04-24 4 MDCO MEDICINES CO /DE
Common Stock A - Award 22,589 452,034 5.26

2018-03-05 2018-03-02 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -22,287 429,445 -4.93 33.29 -741,934 14,296,224

2018-03-02 2018-02-28 4 MDCO MEDICINES CO /DE
Common Stock A - Award 330 451,732 0.07 26.02 8,587 11,754,067

2017-12-19 2017-12-15 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -200,920 0 -100.00

2017-12-19 2017-12-15 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -136,250 451,402 -23.19 27.24 -3,711,450 12,296,190

2017-12-19 2017-12-15 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 200,920 587,652 51.95 19.36 3,889,811 11,376,943

2017-09-05 2017-08-31 4 MDCO MEDICINES CO /DE
Common Stock A - Award 237 386,732 0.06 31.18 7,390 12,058,304

2017-03-02 2017-03-02 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -27,149 386,495 -6.56 52.40 -1,422,608 20,252,338

2017-03-02 2017-03-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) A - Award 210,793 210,793

2017-03-02 2017-03-01 4 MDCO MEDICINES CO /DE
Common Stock A - Award 34,156 413,644 9.00

2017-03-02 2017-02-28 4 MDCO MEDICINES CO /DE
Common Stock A - Award 320 379,488 0.08 33.12 10,598 12,568,643

2016-12-09 2016-12-07 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -40,000 0 -100.00

2016-12-09 2016-12-07 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 40,000 379,168 11.79 28.60 1,144,000 10,844,205

2016-11-17 2016-11-15 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -20,000 40,000 -33.33

2016-11-17 2016-11-15 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -20,000 339,168 -5.57 40.00 -800,054 13,567,636

2016-11-17 2016-11-15 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 20,000 359,168 5.90 28.60 572,000 10,272,205

2016-09-23 2016-09-21 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -8,623 60,000 -12.57

2016-09-23 2016-09-21 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -8,623 339,168 -2.48 40.00 -344,920 13,566,720

2016-09-23 2016-09-21 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 8,623 347,791 2.54 28.60 246,618 9,946,823

2016-09-02 2016-09-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -1,377 68,623 -1.97

2016-09-02 2016-09-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -1,377 339,168 -0.40 40.00 -55,080 13,566,720

2016-09-02 2016-09-01 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 1,377 340,545 0.41 28.60 39,382 9,739,587

2016-09-02 2016-08-31 4 MDCO MEDICINES CO /DE
Common Stock A - Award 378 339,168 0.11 28.08 10,614 9,523,837

2016-08-25 2016-08-24 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -20,000 70,000 -22.22

2016-08-25 2016-08-24 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -20,000 338,790 -5.57 40.00 -800,000 13,551,600

2016-08-25 2016-08-24 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 20,000 358,790 5.90 28.60 572,000 10,261,394

2016-05-18 2016-05-16 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -10,000 90,000 -10.00

2016-05-18 2016-05-16 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -10,000 338,790 -2.87 35.00 -350,000 11,857,650

2016-05-18 2016-05-16 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 10,000 348,790 2.95 28.60 286,000 9,975,394

2016-03-02 2016-03-02 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -21,600 338,790 -5.99 33.85 -731,160 11,468,042

2016-03-02 2016-03-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) A - Award 297,776 297,776

2016-03-02 2016-03-01 4 MDCO MEDICINES CO /DE
Common Stock A - Award 45,400 360,390 14.41

2016-03-02 2016-02-29 4 MDCO MEDICINES CO /DE
Common Stock A - Award 305 314,990 0.10 27.34 8,339 8,611,827

2016-02-29 2016-02-25 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -10,220 314,685 -3.15 32.42 -331,332 10,202,088

2015-09-02 2015-08-31 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -49,998 0 -100.00

2015-09-02 2015-08-31 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -49,998 324,905 -13.34 39.36 -1,967,871 12,787,936

2015-09-02 2015-08-31 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 49,998 374,903 15.39 18.27 913,463 6,849,478

2015-09-02 2015-08-31 4 MDCO MEDICINES CO /DE
Common Stock A - Award 429 324,905 0.13 24.74 10,613 8,038,150

2015-08-04 2015-08-03 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -16,667 49,998 -25.00

2015-08-04 2015-08-03 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -16,667 324,476 -4.89 30.96 -515,960 10,044,804

2015-08-04 2015-08-03 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 16,667 341,143 5.14 18.27 304,506 6,232,683

2015-07-02 2015-07-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -16,667 66,665 -20.00

2015-07-02 2015-07-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -16,667 324,476 -4.89 28.39 -473,243 9,213,172

2015-07-02 2015-07-01 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 16,667 341,143 5.14 18.27 304,506 6,232,683

2015-06-03 2015-06-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -16,667 83,332 -16.67

2015-06-03 2015-06-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -16,667 324,476 -4.89 28.11 -468,441 9,119,690

2015-06-03 2015-06-01 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 16,667 341,143 5.14 18.27 304,506 6,232,683

2015-05-05 2015-05-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -16,667 99,999 -14.29

2015-05-05 2015-05-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -16,667 324,476 -4.89 26.52 -442,029 8,605,493

2015-05-05 2015-05-01 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 16,667 341,143 5.14 18.27 304,506 6,232,683

2015-04-03 2015-04-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -16,667 116,666 -12.50

2015-04-03 2015-04-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -16,667 324,476 -4.89 27.58 -459,598 8,947,523

2015-04-03 2015-04-01 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 16,667 341,143 5.14 18.27 304,506 6,232,683

2015-03-25 2015-03-23 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -16,667 133,333 -11.11

2015-03-25 2015-03-23 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -16,667 324,476 -4.89 30.62 -510,394 9,936,429

2015-03-25 2015-03-23 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 16,667 341,143 5.14 18.27 304,506 6,232,683

2015-03-03 2015-03-02 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -16,470 324,476 -4.83 28.93 -476,479 9,387,123

2015-03-03 2015-03-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) A - Award 234,375 234,375

2015-03-03 2015-03-01 4 MDCO MEDICINES CO /DE
Common Stock A - Award 39,103 340,946 12.95

2015-03-03 2015-02-27 4 MDCO MEDICINES CO /DE
Common Stock A - Award 475 301,843 0.16 22.32 10,602 6,737,136

2015-02-26 2015-02-24 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -12,306 301,368 -3.92 28.67 -352,791 8,639,678

2015-02-20 2015-02-18 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -5,045 313,674 -1.58 28.38 -143,189 8,902,821

2014-09-03 2014-08-29 4 MDCO MEDICINES CO /DE
Common Stock A - Award 415 318,719 0.13 21.77 9,035 6,938,513

2014-03-04 2014-03-03 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -8,643 318,304 -2.64 30.10 -260,141 9,580,473

2014-03-04 2014-03-01 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) A - Award 131,483 131,483

2014-03-04 2014-03-01 4 MDCO MEDICINES CO /DE
Common Stock A - Award 60,082 326,947 22.51

2014-03-04 2014-02-28 4 MDCO MEDICINES CO /DE
Common Stock A - Award 392 266,865 0.15 25.97 10,180 6,930,484

2014-02-27 2014-02-25 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -12,369 266,473 -4.44 30.49 -377,188 8,125,988

2014-02-21 2014-02-20 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -2,603 278,842 -0.92 29.73 -77,391 8,290,391

2014-02-21 2014-02-19 4 MDCO MEDICINES CO /DE
Common Stock F - Taxes -6,328 281,445 -2.20 29.98 -189,719 8,437,974

2014-02-05 2014-02-03 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -10,000 287,773 -3.36 34.29 -342,916 9,868,197

2014-01-08 2014-01-07 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -24,627 0 -100.00

2014-01-08 2014-01-07 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -24,627 297,773 -7.64 38.13 -938,949 11,353,132

2014-01-08 2014-01-07 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 24,627 322,400 8.27 28.02 690,049 9,033,648

2014-01-08 2014-01-06 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -3,302 24,627 -11.82

2014-01-08 2014-01-06 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -3,302 297,773 -1.10 38.13 -125,904 11,353,995

2014-01-08 2014-01-06 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 3,302 301,075 1.11 28.02 92,522 8,436,122

2014-01-06 2014-01-03 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -47,516 27,929 -62.98

2014-01-06 2014-01-03 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -47,516 297,773 -13.76 38.19 -1,814,855 11,373,321

2014-01-06 2014-01-03 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 47,516 345,289 15.96 28.02 1,331,398 9,674,998

2014-01-06 2014-01-02 4 MDCO MEDICINES CO /DE
Stock Option (right-to-buy) M - Exercise -24,555 75,445 -24.56

2014-01-06 2014-01-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -10,000 297,773 -3.25 37.98 -379,757 11,308,138

2014-01-06 2014-01-02 4 MDCO MEDICINES CO /DE
Commom Stock S - Sale X -24,555 307,773 -7.39 37.98 -932,493 11,687,895

2014-01-06 2014-01-02 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 24,555 332,328 7.98 28.02 688,031 9,311,831

2013-12-04 2013-12-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -10,000 307,773 -3.15 36.58 -365,764 11,257,228

2013-11-27 2013-11-26 4 MDCO MEDICINES CO /DE
Option (Right-to-buy) M - Exercise -25,136 0 -100.00

2013-11-27 2013-11-26 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -25,136 317,773 -7.33 36.66 -921,486 11,649,558

2013-11-27 2013-11-26 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 25,136 342,909 7.91 28.01 704,059 9,604,881

2013-11-27 2013-11-25 4 MDCO MEDICINES CO /DE
Option (Right-to-buy) M - Exercise -99,864 25,136 -79.89

2013-11-27 2013-11-25 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -99,864 317,773 -23.91 36.71 -3,666,007 11,665,447

2013-11-27 2013-11-25 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 99,864 417,637 31.43 28.01 2,797,191 11,698,012

2013-11-27 2013-11-25 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -10,000 317,773 -3.05 36.71 -367,100 11,665,447

2013-10-03 2013-10-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 327,773 -2.24 33.45 -250,875 10,964,007

2013-09-05 2013-09-03 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 335,273 -2.19 31.85 -238,875 10,678,445

2013-09-03 2013-08-30 4 MDCO MEDICINES CO /DE
Common Stock J - Other 396 342,773 0.12 26.77 10,601 9,176,033

2013-08-05 2013-08-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 342,377 -2.14 31.26 -234,450 10,702,705

2013-07-02 2013-07-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 349,877 -2.10 31.25 -234,375 10,933,656

2013-05-02 2013-05-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 357,377 -2.06 33.47 -251,025 11,961,408

2013-04-04 2013-04-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 364,877 -2.01 33.37 -250,275 12,175,945

2013-03-05 2013-03-01 4 MDCO MEDICINES CO /DE
Options (Right to Buy) A - Award 64,568 64,568 31.49 2,033,246 2,033,246

2013-03-05 2013-03-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -7,500 372,377 -1.97 31.56 -236,700 11,752,218

2013-03-05 2013-03-01 4 MDCO MEDICINES CO /DE
Common Stock A - Award 65,354 379,877 20.78

2013-03-05 2013-02-28 4 MDCO MEDICINES CO /DE
Common Stock J - Other 474 314,523 0.15 22.39 10,613 7,042,170

2013-02-26 2013-02-25 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -12,303 314,049 -3.77 31.17 -383,485 9,788,907

2013-02-22 2013-02-20 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -8,292 326,352 -2.48 32.42 -268,827 10,580,332

2013-02-21 2013-02-19 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -6,232 334,644 -1.83 31.84 -198,427 10,655,065

2013-02-05 2013-02-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 340,876 -1.45 29.83 -149,150 10,168,331

2013-02-05 2013-02-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -2,500 345,876 -0.72 30.04 -75,100 10,390,115

2013-01-17 2013-01-16 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -2,500 348,376 -0.71 30.00 -75,000 10,451,280

2013-01-04 2013-01-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 350,876 -1.40 24.22 -121,100 8,498,217

2012-11-28 2012-11-26 4 MDCO MEDICINES CO /DE
Option (right to buy) M - Exercise -13,593 0 -100.00

2012-11-28 2012-11-26 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -13,593 355,876 -3.68 21.02 -285,725 7,480,514

2012-11-28 2012-11-26 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 13,593 369,469 3.82 15.50 210,692 5,726,770

2012-10-29 2012-10-25 4 MDCO MEDICINES CO /DE
Option (right to buy) M - Exercise -13,600 13,593 -50.01

2012-10-29 2012-10-25 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -13,600 355,876 -3.68 23.09 -314,024 8,217,177

2012-10-29 2012-10-25 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 13,600 369,476 3.82 15.50 210,800 5,726,878

2012-09-26 2012-09-25 4 MDCO MEDICINES CO /DE
Option (right to buy) M - Exercise -13,600 27,193 -33.34

2012-09-26 2012-09-25 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -13,600 355,876 -3.68 26.31 -357,816 9,363,098

2012-09-26 2012-09-25 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 13,600 369,476 3.82 15.50 210,800 5,726,878

2012-09-04 2012-08-31 4 MDCO MEDICINES CO /DE
Common Stock J - Other 576 355,876 0.16 18.44 10,621 6,562,353

2012-09-04 2012-08-30 4 MDCO MEDICINES CO /DE
Option (right to buy) M - Exercise -13,600 40,793 -25.00

2012-09-04 2012-08-30 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -13,600 355,300 -3.69 25.33 -344,488 8,999,749

2012-09-04 2012-08-30 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 13,600 368,900 3.83 15.50 210,800 5,717,950

2012-07-05 2012-07-02 4 MDCO MEDICINES CO /DE
Option (right to buy) M - Exercise -68,607 54,393 -55.78

2012-07-05 2012-07-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 355,300 -1.39 23.03 -115,150 8,182,559

2012-07-05 2012-07-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -68,607 360,300 -16.00 22.78 -1,562,867 8,207,634

2012-07-05 2012-07-02 4 MDCO MEDICINES CO /DE
Common Stock M - Exercise 68,607 428,907 19.04 15.50 1,063,408 6,648,058

2012-06-04 2012-06-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 360,300 -1.37 21.72 -108,600 7,825,716

2012-05-03 2012-05-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 365,300 -1.35 22.16 -110,800 8,095,048

2012-04-04 2012-04-02 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 370,300 -1.33 20.07 -100,350 7,431,921

2012-03-05 2012-03-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 375,300 -1.31 21.49 -107,450 8,065,197

2012-03-05 2012-03-01 4 MDCO MEDICINES CO /DE
Common Stock J - Other 883 380,300 0.23 12.03 10,622 4,575,009

2012-02-28 2012-02-24 4 MDCO MEDICINES CO /DE
Option (right to buy) A - Award 150,000 150,000 22.04 3,306,000 3,306,000

2012-02-28 2012-02-24 4 MDCO MEDICINES CO /DE
Common Stock A - Award 93,750 379,417 32.82 22.04 2,066,250 8,362,351

2012-02-23 2012-02-21 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -7,063 285,667 -2.41 20.94 -147,899 5,981,867

2012-02-23 2012-02-21 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -1,842 292,730 -0.63 20.94 -38,571 6,129,766

2012-02-23 2012-02-21 4 MDCO MEDICINES CO /DE
Common Stock S - Sale -4,425 294,572 -1.48 20.94 -92,660 6,168,338

2012-02-02 2012-02-01 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -5,000 298,997 -1.64 20.08 -100,400 6,003,860

2012-02-02 2012-01-31 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -2,500 303,997 -0.82 20.00 -50,000 6,079,940

2012-01-05 2012-01-03 4 MDCO MEDICINES CO /DE
Common Stock S - Sale X -2,500 306,497 -0.81 18.99 -47,475 5,820,378

P

Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.

S

Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.

A

Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)

C

Konversi turunan

D

Penjualan atau pengalihan sekuritas kembali ke perusahaan.

F

Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.

G

Pemberian sekuritas oleh atau kepada orang dalam.

K

Swap ekuitas dan transaksi lindung nilai serupa

M

Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)

V

Transaksi yang dilaporkan secara sukarela pada Formulir 4.

J

Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)

Tanggal File	Tanggal Transaksi	Formulir	Ticker	Keamanan	Kode	10b5-1	Saham	Sisa Saham	Persen Ubah	Bagikan Harga	Tran Nilai	Sisa Nilai
2025-01-30		3	MTSR	Metsera, Inc. Common Stock				12,767,462
2024-02-08	2024-02-06	4	GUTS	Fractyl Health, Inc. Common Stock	C - Conversion		277,890	277,890
2022-03-30		3	ADGI	Adagio Therapeutics, Inc. Common Stock				1,201,680
2021-12-20	2021-12-17	4	EQRX	EQRx, Inc. Earn-out Shares	A - Award		42,946	42,946
2021-12-20	2021-12-17	4	EQRX	EQRx, Inc. Stock Option (Right to Buy)	A - Award		313,500	313,500
2021-08-25	2021-08-24	4	PHIC	Population Health Investment Co., Inc. Warrants to purchase Class A Ordinary Share	P - Purchase		20,000	20,000		0.79	15,800	15,800
2021-08-25	2021-08-24	4	PHIC	Population Health Investment Co., Inc. Class A Ordinary Shares	P - Purchase		11,300	11,300		9.80	110,740	110,740
2021-08-25	2021-08-24	4	PHIC	Population Health Investment Co., Inc. Class A Ordinary Shares	P - Purchase		5,100	16,400	45.13	9.79	49,929	160,556
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-95,000	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-117,000	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-117,000	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-234,000	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-87,750	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-210,793	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-297,776	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-234,375	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Stock Option	D - Sale to Issuer		-120,000	0	-100.00
2020-01-06	2020-01-06	4	MDCO	MEDICINES CO /DE Common Stock	D - Sale to Issuer		-480,340	0	-100.00
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Stock Option	M - Exercise		-11,483	120,000	-8.73
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Stock Option	M - Exercise		-64,568	0	-100.00
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Stock Option	M - Exercise		-150,000	0	-100.00
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Stock Option	M - Exercise		-240,000	0	-100.00
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Stock Option	M - Exercise		-15,620	0	-100.00
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Stock Option	M - Exercise		-60,000	0	-100.00
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-22,345	480,340	-4.45	84.78	-1,894,409	40,723,225
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-329,796	502,685	-39.62	84.78	-27,960,105	42,617,634
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		11,483	832,481	1.40	30.55	350,806	25,432,295
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		64,568	820,998	8.54	31.49	2,033,246	25,853,227
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		150,000	756,430	24.73	22.04	3,306,000	16,671,717
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		240,000	606,430	65.50	17.45	4,188,000	10,582,204
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		15,620	366,430	4.45	13.54	211,495	4,961,462
2019-12-31	2019-12-27	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		60,000	350,810	20.63	7.31	438,600	2,564,421
2019-09-04	2019-08-30	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		491	290,810	0.17	21.60	10,606	6,281,496
2019-04-26	2019-04-25	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-2,796	290,319	-0.95	30.48	-85,222	8,848,923
2019-03-06	2019-03-04	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-2,962	293,115	-1.00	25.53	-75,620	7,483,226
2019-03-06	2019-03-04	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-3,586	296,077	-1.20	25.53	-91,551	7,558,846
2019-03-06	2019-03-04	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-3,063	299,663	-1.01	25.53	-78,198	7,650,396
2019-03-04	2019-03-01	4	MDCO	MEDICINES CO /DE Stock option (right to buy)	A - Award		95,000	95,000
2019-03-04	2019-02-28	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		317	302,726	0.10	20.97	6,647	6,348,164
2018-09-05	2018-09-04	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-50,000	302,409	-14.19	39.31	-1,965,500	11,887,698
2018-09-05	2018-08-31	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		375	352,409	0.11	28.28	10,605	9,966,127
2018-08-02	2018-08-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-50,000	352,034	-12.44	39.24	-1,962,000	13,813,814
2018-07-05	2018-07-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-50,000	402,034	-11.06	36.07	-1,803,500	14,501,366
2018-04-26	2018-04-24	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		22,589	452,034	5.26
2018-03-05	2018-03-02	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-22,287	429,445	-4.93	33.29	-741,934	14,296,224
2018-03-02	2018-02-28	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		330	451,732	0.07	26.02	8,587	11,754,067
2017-12-19	2017-12-15	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-200,920	0	-100.00
2017-12-19	2017-12-15	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-136,250	451,402	-23.19	27.24	-3,711,450	12,296,190
2017-12-19	2017-12-15	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		200,920	587,652	51.95	19.36	3,889,811	11,376,943
2017-09-05	2017-08-31	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		237	386,732	0.06	31.18	7,390	12,058,304
2017-03-02	2017-03-02	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-27,149	386,495	-6.56	52.40	-1,422,608	20,252,338
2017-03-02	2017-03-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	A - Award		210,793	210,793
2017-03-02	2017-03-01	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		34,156	413,644	9.00
2017-03-02	2017-02-28	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		320	379,488	0.08	33.12	10,598	12,568,643
2016-12-09	2016-12-07	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-40,000	0	-100.00
2016-12-09	2016-12-07	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		40,000	379,168	11.79	28.60	1,144,000	10,844,205
2016-11-17	2016-11-15	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-20,000	40,000	-33.33
2016-11-17	2016-11-15	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-20,000	339,168	-5.57	40.00	-800,054	13,567,636
2016-11-17	2016-11-15	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		20,000	359,168	5.90	28.60	572,000	10,272,205
2016-09-23	2016-09-21	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-8,623	60,000	-12.57
2016-09-23	2016-09-21	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-8,623	339,168	-2.48	40.00	-344,920	13,566,720
2016-09-23	2016-09-21	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		8,623	347,791	2.54	28.60	246,618	9,946,823
2016-09-02	2016-09-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-1,377	68,623	-1.97
2016-09-02	2016-09-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-1,377	339,168	-0.40	40.00	-55,080	13,566,720
2016-09-02	2016-09-01	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		1,377	340,545	0.41	28.60	39,382	9,739,587
2016-09-02	2016-08-31	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		378	339,168	0.11	28.08	10,614	9,523,837
2016-08-25	2016-08-24	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-20,000	70,000	-22.22
2016-08-25	2016-08-24	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-20,000	338,790	-5.57	40.00	-800,000	13,551,600
2016-08-25	2016-08-24	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		20,000	358,790	5.90	28.60	572,000	10,261,394
2016-05-18	2016-05-16	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-10,000	90,000	-10.00
2016-05-18	2016-05-16	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-10,000	338,790	-2.87	35.00	-350,000	11,857,650
2016-05-18	2016-05-16	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		10,000	348,790	2.95	28.60	286,000	9,975,394
2016-03-02	2016-03-02	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-21,600	338,790	-5.99	33.85	-731,160	11,468,042
2016-03-02	2016-03-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	A - Award		297,776	297,776
2016-03-02	2016-03-01	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		45,400	360,390	14.41
2016-03-02	2016-02-29	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		305	314,990	0.10	27.34	8,339	8,611,827
2016-02-29	2016-02-25	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-10,220	314,685	-3.15	32.42	-331,332	10,202,088
2015-09-02	2015-08-31	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-49,998	0	-100.00
2015-09-02	2015-08-31	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-49,998	324,905	-13.34	39.36	-1,967,871	12,787,936
2015-09-02	2015-08-31	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		49,998	374,903	15.39	18.27	913,463	6,849,478
2015-09-02	2015-08-31	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		429	324,905	0.13	24.74	10,613	8,038,150
2015-08-04	2015-08-03	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-16,667	49,998	-25.00
2015-08-04	2015-08-03	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-16,667	324,476	-4.89	30.96	-515,960	10,044,804
2015-08-04	2015-08-03	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		16,667	341,143	5.14	18.27	304,506	6,232,683
2015-07-02	2015-07-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-16,667	66,665	-20.00
2015-07-02	2015-07-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-16,667	324,476	-4.89	28.39	-473,243	9,213,172
2015-07-02	2015-07-01	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		16,667	341,143	5.14	18.27	304,506	6,232,683
2015-06-03	2015-06-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-16,667	83,332	-16.67
2015-06-03	2015-06-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-16,667	324,476	-4.89	28.11	-468,441	9,119,690
2015-06-03	2015-06-01	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		16,667	341,143	5.14	18.27	304,506	6,232,683
2015-05-05	2015-05-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-16,667	99,999	-14.29
2015-05-05	2015-05-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-16,667	324,476	-4.89	26.52	-442,029	8,605,493
2015-05-05	2015-05-01	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		16,667	341,143	5.14	18.27	304,506	6,232,683
2015-04-03	2015-04-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-16,667	116,666	-12.50
2015-04-03	2015-04-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-16,667	324,476	-4.89	27.58	-459,598	8,947,523
2015-04-03	2015-04-01	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		16,667	341,143	5.14	18.27	304,506	6,232,683
2015-03-25	2015-03-23	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-16,667	133,333	-11.11
2015-03-25	2015-03-23	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-16,667	324,476	-4.89	30.62	-510,394	9,936,429
2015-03-25	2015-03-23	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		16,667	341,143	5.14	18.27	304,506	6,232,683
2015-03-03	2015-03-02	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-16,470	324,476	-4.83	28.93	-476,479	9,387,123
2015-03-03	2015-03-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	A - Award		234,375	234,375
2015-03-03	2015-03-01	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		39,103	340,946	12.95
2015-03-03	2015-02-27	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		475	301,843	0.16	22.32	10,602	6,737,136
2015-02-26	2015-02-24	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-12,306	301,368	-3.92	28.67	-352,791	8,639,678
2015-02-20	2015-02-18	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-5,045	313,674	-1.58	28.38	-143,189	8,902,821
2014-09-03	2014-08-29	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		415	318,719	0.13	21.77	9,035	6,938,513
2014-03-04	2014-03-03	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-8,643	318,304	-2.64	30.10	-260,141	9,580,473
2014-03-04	2014-03-01	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	A - Award		131,483	131,483
2014-03-04	2014-03-01	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		60,082	326,947	22.51
2014-03-04	2014-02-28	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		392	266,865	0.15	25.97	10,180	6,930,484
2014-02-27	2014-02-25	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-12,369	266,473	-4.44	30.49	-377,188	8,125,988
2014-02-21	2014-02-20	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-2,603	278,842	-0.92	29.73	-77,391	8,290,391
2014-02-21	2014-02-19	4	MDCO	MEDICINES CO /DE Common Stock	F - Taxes		-6,328	281,445	-2.20	29.98	-189,719	8,437,974
2014-02-05	2014-02-03	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-10,000	287,773	-3.36	34.29	-342,916	9,868,197
2014-01-08	2014-01-07	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-24,627	0	-100.00
2014-01-08	2014-01-07	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-24,627	297,773	-7.64	38.13	-938,949	11,353,132
2014-01-08	2014-01-07	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		24,627	322,400	8.27	28.02	690,049	9,033,648
2014-01-08	2014-01-06	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-3,302	24,627	-11.82
2014-01-08	2014-01-06	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-3,302	297,773	-1.10	38.13	-125,904	11,353,995
2014-01-08	2014-01-06	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		3,302	301,075	1.11	28.02	92,522	8,436,122
2014-01-06	2014-01-03	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-47,516	27,929	-62.98
2014-01-06	2014-01-03	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-47,516	297,773	-13.76	38.19	-1,814,855	11,373,321
2014-01-06	2014-01-03	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		47,516	345,289	15.96	28.02	1,331,398	9,674,998
2014-01-06	2014-01-02	4	MDCO	MEDICINES CO /DE Stock Option (right-to-buy)	M - Exercise		-24,555	75,445	-24.56
2014-01-06	2014-01-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-10,000	297,773	-3.25	37.98	-379,757	11,308,138
2014-01-06	2014-01-02	4	MDCO	MEDICINES CO /DE Commom Stock	S - Sale	X	-24,555	307,773	-7.39	37.98	-932,493	11,687,895
2014-01-06	2014-01-02	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		24,555	332,328	7.98	28.02	688,031	9,311,831
2013-12-04	2013-12-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-10,000	307,773	-3.15	36.58	-365,764	11,257,228
2013-11-27	2013-11-26	4	MDCO	MEDICINES CO /DE Option (Right-to-buy)	M - Exercise		-25,136	0	-100.00
2013-11-27	2013-11-26	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-25,136	317,773	-7.33	36.66	-921,486	11,649,558
2013-11-27	2013-11-26	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		25,136	342,909	7.91	28.01	704,059	9,604,881
2013-11-27	2013-11-25	4	MDCO	MEDICINES CO /DE Option (Right-to-buy)	M - Exercise		-99,864	25,136	-79.89
2013-11-27	2013-11-25	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-99,864	317,773	-23.91	36.71	-3,666,007	11,665,447
2013-11-27	2013-11-25	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		99,864	417,637	31.43	28.01	2,797,191	11,698,012
2013-11-27	2013-11-25	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-10,000	317,773	-3.05	36.71	-367,100	11,665,447
2013-10-03	2013-10-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	327,773	-2.24	33.45	-250,875	10,964,007
2013-09-05	2013-09-03	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	335,273	-2.19	31.85	-238,875	10,678,445
2013-09-03	2013-08-30	4	MDCO	MEDICINES CO /DE Common Stock	J - Other		396	342,773	0.12	26.77	10,601	9,176,033
2013-08-05	2013-08-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	342,377	-2.14	31.26	-234,450	10,702,705
2013-07-02	2013-07-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	349,877	-2.10	31.25	-234,375	10,933,656
2013-05-02	2013-05-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	357,377	-2.06	33.47	-251,025	11,961,408
2013-04-04	2013-04-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	364,877	-2.01	33.37	-250,275	12,175,945
2013-03-05	2013-03-01	4	MDCO	MEDICINES CO /DE Options (Right to Buy)	A - Award		64,568	64,568		31.49	2,033,246	2,033,246
2013-03-05	2013-03-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-7,500	372,377	-1.97	31.56	-236,700	11,752,218
2013-03-05	2013-03-01	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		65,354	379,877	20.78
2013-03-05	2013-02-28	4	MDCO	MEDICINES CO /DE Common Stock	J - Other		474	314,523	0.15	22.39	10,613	7,042,170
2013-02-26	2013-02-25	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-12,303	314,049	-3.77	31.17	-383,485	9,788,907
2013-02-22	2013-02-20	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-8,292	326,352	-2.48	32.42	-268,827	10,580,332
2013-02-21	2013-02-19	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-6,232	334,644	-1.83	31.84	-198,427	10,655,065
2013-02-05	2013-02-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	340,876	-1.45	29.83	-149,150	10,168,331
2013-02-05	2013-02-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-2,500	345,876	-0.72	30.04	-75,100	10,390,115
2013-01-17	2013-01-16	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-2,500	348,376	-0.71	30.00	-75,000	10,451,280
2013-01-04	2013-01-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	350,876	-1.40	24.22	-121,100	8,498,217
2012-11-28	2012-11-26	4	MDCO	MEDICINES CO /DE Option (right to buy)	M - Exercise		-13,593	0	-100.00
2012-11-28	2012-11-26	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-13,593	355,876	-3.68	21.02	-285,725	7,480,514
2012-11-28	2012-11-26	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		13,593	369,469	3.82	15.50	210,692	5,726,770
2012-10-29	2012-10-25	4	MDCO	MEDICINES CO /DE Option (right to buy)	M - Exercise		-13,600	13,593	-50.01
2012-10-29	2012-10-25	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-13,600	355,876	-3.68	23.09	-314,024	8,217,177
2012-10-29	2012-10-25	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		13,600	369,476	3.82	15.50	210,800	5,726,878
2012-09-26	2012-09-25	4	MDCO	MEDICINES CO /DE Option (right to buy)	M - Exercise		-13,600	27,193	-33.34
2012-09-26	2012-09-25	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-13,600	355,876	-3.68	26.31	-357,816	9,363,098
2012-09-26	2012-09-25	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		13,600	369,476	3.82	15.50	210,800	5,726,878
2012-09-04	2012-08-31	4	MDCO	MEDICINES CO /DE Common Stock	J - Other		576	355,876	0.16	18.44	10,621	6,562,353
2012-09-04	2012-08-30	4	MDCO	MEDICINES CO /DE Option (right to buy)	M - Exercise		-13,600	40,793	-25.00
2012-09-04	2012-08-30	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-13,600	355,300	-3.69	25.33	-344,488	8,999,749
2012-09-04	2012-08-30	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		13,600	368,900	3.83	15.50	210,800	5,717,950
2012-07-05	2012-07-02	4	MDCO	MEDICINES CO /DE Option (right to buy)	M - Exercise		-68,607	54,393	-55.78
2012-07-05	2012-07-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	355,300	-1.39	23.03	-115,150	8,182,559
2012-07-05	2012-07-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-68,607	360,300	-16.00	22.78	-1,562,867	8,207,634
2012-07-05	2012-07-02	4	MDCO	MEDICINES CO /DE Common Stock	M - Exercise		68,607	428,907	19.04	15.50	1,063,408	6,648,058
2012-06-04	2012-06-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	360,300	-1.37	21.72	-108,600	7,825,716
2012-05-03	2012-05-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	365,300	-1.35	22.16	-110,800	8,095,048
2012-04-04	2012-04-02	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	370,300	-1.33	20.07	-100,350	7,431,921
2012-03-05	2012-03-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	375,300	-1.31	21.49	-107,450	8,065,197
2012-03-05	2012-03-01	4	MDCO	MEDICINES CO /DE Common Stock	J - Other		883	380,300	0.23	12.03	10,622	4,575,009
2012-02-28	2012-02-24	4	MDCO	MEDICINES CO /DE Option (right to buy)	A - Award		150,000	150,000		22.04	3,306,000	3,306,000
2012-02-28	2012-02-24	4	MDCO	MEDICINES CO /DE Common Stock	A - Award		93,750	379,417	32.82	22.04	2,066,250	8,362,351
2012-02-23	2012-02-21	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-7,063	285,667	-2.41	20.94	-147,899	5,981,867
2012-02-23	2012-02-21	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-1,842	292,730	-0.63	20.94	-38,571	6,129,766
2012-02-23	2012-02-21	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale		-4,425	294,572	-1.48	20.94	-92,660	6,168,338
2012-02-02	2012-02-01	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-5,000	298,997	-1.64	20.08	-100,400	6,003,860
2012-02-02	2012-01-31	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-2,500	303,997	-0.82	20.00	-50,000	6,079,940
2012-01-05	2012-01-03	4	MDCO	MEDICINES CO /DE Common Stock	S - Sale	X	-2,500	306,497	-0.81	18.99	-47,475	5,820,378