Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

Pendahuluan

Halaman ini memberikan analisis komprehensif tentang sejarah perdagangan orang dalam yang diketahui dari Joseph Iii Klein. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Adalah ilegal bagi orang dalam untuk melakukan perdagangan di perusahaan mereka berdasarkan informasi spesifik yang tidak dipublikasikan. Ini tidak berarti bahwa mereka dilarang melakukan perdagangan apa pun di perusahaan mereka sendiri. Namun, mereka harus melaporkan semua perdagangan kepada SEC melalui Formulir 4. Terlepas dari pembatasan ini, penelitian akademis menunjukkan bahwa orang dalam - secara umum - cenderung mengungguli pasar di perusahaan mereka sendiri.

Rata-rata Profitabilitas Perdagangan

Profitabilitas perdagangan rata-rata adalah pengembalian rata-rata dari semua pembelian pasar terbuka yang dilakukan oleh orang dalam dalam tiga tahun terakhir. Untuk menghitung ini, kami memeriksa setiap pembelian pasar terbuka yang tidak direncanakan yang dilakukan oleh orang dalam, tidak termasuk semua perdagangan yang ditandai sebagai bagian dari rencana perdagangan 10b5-1. Kami kemudian menghitung kinerja rata-rata dari perdagangan tersebut selama 3, 6, dan 12 bulan, dengan merata-ratakan setiap durasi tersebut untuk menghasilkan metrik kinerja akhir untuk setiap perdagangan. Terakhir, kami merata-ratakan semua metrik kinerja untuk menghitung metrik kinerja untuk orang dalam. Daftar ini hanya mencakup orang dalam yang telah melakukan setidaknya tiga perdagangan dalam dua tahun terakhir.

Jika profitabilitas perdagangan orang dalam ini adalah "N/A", maka orang dalam tersebut belum melakukan pembelian di pasar terbuka dalam tiga tahun terakhir, atau perdagangan yang mereka lakukan terlalu baru untuk menghitung metrik kinerja yang andal.

Frekuensi Pembaruan: Setiap Hari

Lihat daftar pedagang dalam perusahaan yang paling menguntungkan.

Perusahaan dengan Posisi Orang Dalam yang Dilaporkan

Pengajuan SEC menunjukkan bahwa Joseph Iii Klein telah melaporkan kepemilikan atau perdagangan di perusahaan-perusahaan berikut:

Keamanan Judul Kepemilikan Terakhir yang Dilaporkan
US:IONS / Ionis Pharmaceuticals, Inc. Director 0
Director 0
US:69329YAE4 / PDL BioPharma, Inc. Bond 2.875% Director 16,983
Cara Membaca Grafik

Grafik berikut menunjukkan kinerja saham sekuritas setelah setiap perdagangan pasar terbuka yang tidak direncanakan yang dilakukan oleh Joseph Iii Klein. Perdagangan yang tidak direncanakan adalah perdagangan yang tidak dilakukan sebagai bagian dari rencana perdagangan 10b5-1. Kinerja saham digambarkan sebagai perubahan persentase kumulatif dalam harga saham. Misalnya, jika perdagangan orang dalam dilakukan pada 1 Januari 2019, grafik akan menunjukkan perubahan persentase harian sekuritas hingga saat ini. Jika harga saham naik dari $10 menjadi $15 selama periode ini, perubahan persentase kumulatif dalam harga saham akan menjadi 50%. Perubahan harga dari $10 menjadi $20 akan menjadi 100%, dan perubahan harga dari $10 menjadi $5 akan menjadi -50%.

Pada akhirnya, kita mencoba menentukan seberapa erat korelasi perdagangan orang dalam dengan pengembalian berlebih (positif atau negatif) pada harga saham untuk melihat apakah orang dalam tersebut mengatur waktu perdagangannya untuk mendapatkan keuntungan dari informasi orang dalam. Pertimbangkan situasi di mana orang dalam melakukan hal ini. Dalam situasi ini, kita akan mengharapkan (a) pengembalian positif setelah pembelian, atau (b) pengembalian negatif setelah penjualan. Dalam kasus (a), grafik PEMBELIAN akan menunjukkan serangkaian kurva yang miring ke atas, menunjukkan pengembalian positif setelah setiap transaksi pembelian. Dalam kasus (b), grafik PENJUALAN akan menunjukkan serangkaian kurva yang miring ke bawah, menunjukkan pengembalian negatif setelah setiap transaksi penjualan.

Namun, ini saja tidak cukup untuk menarik kesimpulan. Jika, misalnya, harga saham perusahaan berada dalam tren kenaikan non-siklikal selama bertahun-tahun, maka kita akan mengharapkan semua plot pasca-pembelian memiliki kemiringan ke atas. Demikian pula, penurunan non-siklikal selama bertahun-tahun akan menghasilkan plot pasca-perdagangan dengan kemiringan ke bawah. Tak satu pun dari grafik ini akan menunjukkan aktivitas perdagangan orang dalam.

Indikator terkuat adalah situasi di mana harga saham sangat siklikal, dan terdapat sinyal positif pada grafik PEMBELIAN dan plot negatif pada grafik PENJUALAN. Situasi ini akan sangat menunjukkan adanya orang dalam yang mengatur waktu perdagangan untuk keuntungan finansial mereka.

Pembelian Orang Dalam IONS / Ionis Pharmaceuticals, Inc. - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di IONS / Ionis Pharmaceuticals, Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham
Dilaporkan
Harga
Disesuaikan
Saham
Disesuaikan
Harga
Dasar Biaya Hari-hari menuju
Maksimal
Harga di
Maksimal
Maksimal
Keuntungan ($)
Maksimum Pengembalian (%)
Tidak ada transaksi pasar terbuka tak terduga yang diketahui untuk kombinasi orang dalam dan sekuritas ini.

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Penjualan Orang Dalam IONS / Ionis Pharmaceuticals, Inc. - Analisis Kerugian Jangka Pendek

Pada bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan internal pasar terbuka yang tidak direncanakan yang dilakukan di IONS / Ionis Pharmaceuticals, Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham
Dilaporkan
Harga
Disesuaikan
Saham
Disesuaikan
Harga
Dasar Biaya Hari-hari menuju
Menit
Harga di
Menit
Kerugian Maksimal
Dihindari ($)
Kerugian Maksimal
Dihindari (%)
2024-05-03 IONS KLEIN JOSEPH III 1,318 42.5721 1,318 42.5721 56,110 340 25.5100 -22,488 -40.08
2024-05-03 IONS KLEIN JOSEPH III 682 42.9449 682 42.9449 29,288
2024-05-03 IONS KLEIN JOSEPH III 1,269 42.5875 1,269 42.5875 54,044
2024-05-03 IONS KLEIN JOSEPH III 731 42.9767 731 42.9767 31,416
2024-05-03 IONS KLEIN JOSEPH III 1,070 42.5473 1,070 42.5473 45,526
2024-05-03 IONS KLEIN JOSEPH III 930 42.8957 930 42.8957 39,893
2015-11-11 ISIS KLEIN JOSEPH III 3,750 64.1795 3,750 64.1795 240,673
2015-11-11 ISIS KLEIN JOSEPH III 3,125 64.1795 3,125 64.1795 200,561
2015-03-05 ISIS KLEIN JOSEPH III 7,000 70.9545 7,000 70.9545 496,682
2014-01-24 ISIS KLEIN JOSEPH III 7,500 48.6797 7,500 48.6797 365,098
2014-01-24 ISIS KLEIN JOSEPH III 2,813 48.6102 2,813 48.6102 136,740
2013-11-25 ISIS KLEIN JOSEPH III 6,000 36.8594 6,000 36.8594 221,156
2013-08-09 ISIS KLEIN JOSEPH III 103 28.2300 103 28.2300 2,908
2013-08-09 ISIS KLEIN JOSEPH III 3,647 28.2200 3,647 28.2200 102,918
2013-08-09 ISIS KLEIN JOSEPH III 7,500 28.2200 7,500 28.2200 211,650
2013-08-09 ISIS KLEIN JOSEPH III 7,500 28.2200 7,500 28.2200 211,650

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Sejarah Perdagangan Orang Dalam

Tabel ini menunjukkan daftar lengkap transaksi orang dalam yang dilakukan oleh Joseph Iii Klein sebagaimana diungkapkan kepada Komisi Bursa Efek (Securities Exchange Commission/SEC).

Tanggal File Tanggal Transaksi Formulir Ticker Keamanan Kode 10b5-1 Saham Sisa Saham Persen
Ubah
Bagikan
Harga
Tran
Nilai
Sisa
Nilai
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -28,000 0 -100.00 60.00 -1,680,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 28,000 75.00
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 16,000 16,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -28,000 0 -100.00 60.00 -1,680,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 28,000 75.00
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 16,000 16,000
2024-07-17 2024-07-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,000 0 -100.00 50.00 -600,000
2024-07-17 2024-07-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 12,000 24.42 293,040 293,040
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -930 0 -100.00 42.90 -39,893
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,070 930 -53.50 42.55 -45,526 39,569
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -731 2,000 -26.77 42.98 -31,416 85,953
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,269 2,731 -31.72 42.59 -54,044 116,306
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -682 4,000 -14.57 42.94 -29,288 171,780
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,318 4,682 -21.97 42.57 -56,110 199,323
2023-11-17 2023-11-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 16,346 -10.90 50.00 -100,000 817,300
2023-09-28 2023-09-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 18,346 -9.83 45.13 -90,254 827,896
2023-07-19 2023-07-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,555 20,346 -14.87 42.00 -149,310 854,532
2023-07-19 2023-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5,333 23,901 28.72
2023-07-19 2023-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,777 18,568 10.58
2023-01-18 2023-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 16,791 -10.64 40.00 -80,000 671,640
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -644 18,791 -3.31 38.78 -24,974 728,715
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -689 19,435 -3.42 37.74 -26,003 733,477
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,665 20,124 15.26
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5,333 17,459 43.98
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 8,000 8,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 12,000 12,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 12,000 12,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 16,000 16,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 16,000 16,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 12,000 12,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -8,000 8,000 -50.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -12,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -12,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -16,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -16,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -12,000 4,000 -75.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Common Stock
G - Gift 6,000 6,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Common Stock
G - Gift -6,000 12,126 -33.10
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -1,778 9,775 -15.39
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -666 11,553 -5.45
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -889 12,219 -6.78
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -5,333 13,108 -28.92
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,334 18,126 -19.30 35.30 -152,989 639,844
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,778 22,460 8.60
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 666 20,682 3.33
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 889 20,016 4.65
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5,333 19,127 38.66
2021-07-06 2021-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
A - Award 5,333 18,441 40.69
2021-07-06 2021-07-01 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
A - Award 12,000 12,000
2020-10-22 2020-10-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,889 13,794 -17.32 46.86 -135,386 646,421
2020-10-13 2020-10-12 4 AKCA AKCEA THERAPEUTICS, INC.
Stock Option (right to buy)
D - Sale to Issuer -26,400 0 -100.00 2.01 -53,064
2020-07-06 2020-07-06 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 666 -50.04
2020-07-06 2020-07-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 16,683 4.16
2020-07-06 2020-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -889 1,777 -33.35
2020-07-06 2020-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 889 16,016 5.88
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 12,000 12,000
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5,333 5,333
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,778 5,332 -25.01
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -666 0 -100.00
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,778 15,127 13.32
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 666 13,349 5.25
2020-04-15 2020-04-13 4 AKCA AKCEA THERAPEUTICS, INC.
Stock Option (right to buy)
A - Award 26,400 26,400
2019-12-23 2019-12-23 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 0 -100.00
2019-12-23 2019-12-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 61.87 -61,874 784,750
2019-12-23 2019-12-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-12-18 2019-12-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 1,000 -50.00
2019-12-18 2019-12-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 65.45 -65,446 830,058
2019-12-18 2019-12-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-12-10 2019-12-09 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 2,000 -33.33
2019-12-10 2019-12-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 63.74 -63,745 808,474
2019-12-10 2019-12-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-12-04 2019-12-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 3,000 -25.00
2019-12-04 2019-12-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 64.08 -64,083 812,765
2019-12-04 2019-12-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-11-26 2019-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -812 12,683 -6.02 62.90 -51,075 797,761
2019-11-21 2019-11-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 13,495 -12.91 60.00 -120,000 809,700
2019-09-23 2019-09-20 4 AKCA AKCEA THERAPEUTICS, INC.
Stock Option (right to buy)
A - Award 53,000 53,000
2019-07-03 2019-07-03 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 1,333 -33.35
2019-07-03 2019-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 15,495 4.50
2019-07-03 2019-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -889 2,666 -25.01
2019-07-03 2019-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 889 14,828 6.38
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 7,110 7,110
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 666 -50.04
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -666 0 -100.00
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 13,939 5.03
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 666 13,272 5.28
2018-07-03 2018-07-03 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 2,000 -25.01
2018-07-03 2018-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 12,606 5.59
2018-07-03 2018-07-02 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2018-07-03 2018-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 3,555 3,555
2018-07-03 2018-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2,000 1,999 -50.01
2018-07-03 2018-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,000 11,939 20.12
2018-03-30 2018-03-29 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 2,000 0 -100.00
2018-03-30 2018-03-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 9,939 -16.75 46.15 -92,300 458,685
2018-03-30 2018-03-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,000 11,939 20.12 24.42 48,840 291,550
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 2,000 2,000
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 9,939 -1.97 52.11 -10,422 517,921
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 10,139 2.01 24.42 4,884 247,594
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 9,939 -8.30 51.59 -46,431 512,753
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 10,839 9.06 24.42 21,978 264,688
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 10,839 9.06 24.42 21,978 264,688
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 9,939 -8.30 50.45 -45,405 501,423
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 3,000 0 -100.00
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,100 9,939 -17.44 52.29 -109,809 519,710
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,100 12,039 21.13 35.53 74,613 427,746
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 9,939 -8.30 51.02 -45,918 507,088
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 10,839 9.06 35.53 31,977 385,110
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 3,000 3,000
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,600 9,939 -13.87 49.20 -78,720 488,999
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,600 11,539 16.10 35.53 56,848 409,981
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,400 9,939 -12.35 48.76 -68,264 484,626
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,400 11,339 14.09 35.53 49,742 402,875
2018-01-31 2018-01-30 4/A IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 3,000 6,000 100.00
2018-01-31 2018-01-30 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 52.86 -158,580 525,376
2018-01-31 2018-01-30 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 35.53 106,590 459,723
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -3,000 9,000 -25.00
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,400 9,939 -12.35 52.97 -74,158 526,469
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,400 11,339 14.09 35.53 49,742 402,875
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,600 9,939 -13.87 52.13 -83,408 518,120
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,600 11,539 16.10 35.53 56,848 409,981
2018-01-02 2017-12-29 4 IONS IONIS PHARMACEUTICALS INC
Non-Employee Director Stock Option (right to buy)
M - Exercise -3,000 0 -100.00
2018-01-02 2017-12-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 50.56 -151,680 502,516
2018-01-02 2017-12-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 28.47 85,410 368,373
2017-12-19 2017-12-15 4 IONS IONIS PHARMACEUTICALS INC
NonEmployee Director stock option (right to buy)
M - Exercise -3,000 3,000 -50.00
2017-12-19 2017-12-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 51.69 -155,070 513,747
2017-12-19 2017-12-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 28.47 85,410 368,373
2017-12-01 2017-11-30 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,000 6,000 -33.33
2017-12-01 2017-11-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 53.55 -160,650 532,233
2017-12-01 2017-11-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 28.47 85,410 368,373
2017-11-17 2017-11-16 4 IONS IONIS PHARMACEUTICALS INC
Non-Employee Director Stock Option (right to buy)
M - Exercise -2,812 0 -100.00
2017-11-17 2017-11-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,812 9,939 39.46 12.94 36,387 128,611
2017-11-17 2017-11-15 4 IONS IONIS PHARMACEUTICALS INC
Non-Employee Director Stock Option (right to buy)
M - Exercise -2,250 9,000 -20.00
2017-11-17 2017-11-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,250 7,127 -23.99 53.56 -120,510 381,722
2017-11-17 2017-11-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,250 9,377 31.57 28.47 64,058 266,963
2017-11-14 2017-11-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 7,127 -29.62 55.39 -166,170 394,765
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2017-07-03 2017-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,469 10,127 32.24
2017-07-03 2017-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2,469 3,999 -38.17
2016-07-06 2016-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -312 0 -100.00
2016-07-06 2016-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 312 7,658 4.25
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,803 3,801 -32.17
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 469 7,346 6.82
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 6,877 10.74
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 6,877 10.74
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,125 2,812 -52.64
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -3,125 5,543 -36.05 64.18 -200,561 355,747
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,125 8,668 56.38 12.94 40,438 112,164
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -3,750 5,543 -40.35 64.18 -240,673 355,747
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,750 9,293 67.65 9.30 34,875 86,425
2015-07-02 2015-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -312 312 -50.00
2015-07-02 2015-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 312 5,543 5.96
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 2,000 -25.01
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -469 937 -33.36
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 5,231 14.61
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 469 4,564 11.45
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 5,937 -29.63
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 3,750 -50.00
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 3,750 -50.00
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,000 4,095 -63.09 70.95 -496,682 290,559
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,500 11,095 29.09 12.94 32,350 143,569
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,750 8,595 77.40 9.30 34,875 79,934
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,750 4,845 342.47 9.22 34,575 44,671
2015-02-13 2015-02-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
G - Gift -2,000 1,095 -64.62
2014-07-02 2014-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -313 624 -33.40
2014-07-02 2014-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 313 3,095 11.25
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -469 1,406 -25.01
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 469 2,782 20.28
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,813 8,437 -25.00
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -7,500 0 -100.00
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -2,813 2,313 -54.88 48.61 -136,740 112,435
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,813 5,126 121.62 12.94 36,400 66,330
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,500 2,313 -76.43 48.68 -365,098 112,596
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,500 9,813 324.25 16.32 122,400 160,148
2013-11-27 2013-11-25 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,000 2,313 -72.18 36.86 -221,156 85,256
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -7,500 7,500 -50.00
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -7,500 7,500 -50.00
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,500 8,313 -47.43 28.22 -211,650 234,593
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,500 8,313 -47.43 28.22 -211,650 234,593
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,500 15,813 90.22 9.22 69,150 145,796
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,500 15,813 90.22 9.30 69,750 147,061
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -3,647 8,313 -30.49 28.22 -102,918 234,593
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,647 11,960 43.87 13.88 50,620 166,005
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -103 8,313 -1.22 28.23 -2,908 234,676
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 103 8,416 1.24 13.88 1,430 116,814
2013-07-03 2013-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -313 937 -25.04
2013-07-03 2013-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 313 8,313 3.91
2013-07-03 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1,875 1,875
2013-07-03 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 11,250 11,250
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -174 0 -100.00 18.00 -3,132
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 174 174 5.93 1,032 1,032
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,250 0 -100.00 18.00 -22,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,250 1,250 9.22 11,525 11,525
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,500 0 -100.00 18.00 -45,000
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,500 2,500 16.32 40,800 40,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -174 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -174 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -1,250 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -1,250 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -4,167 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -4,167 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -1,250 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -173 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -4,166 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,167 0 -100.00 18.00 -75,006
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,167 0 -100.00 18.00 -75,006
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,167 4,167 9.77 40,712 40,712
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,167 4,167 9.77 40,712 40,712
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,750 0 -100.00 18.00 -67,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,750 3,750 13.88 52,050 52,050
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -174 0 -100.00 18.00 -3,132
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 174 174 5.93 1,032 1,032
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,250 0 -100.00 18.00 -22,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,250 0 -100.00 18.00 -22,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,250 1,250 9.22 11,525 11,525
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,250 1,250 9.22 11,525 11,525
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,500 0 -100.00 18.00 -45,000
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,500 2,500 16.32 40,800 40,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,750 0 -100.00 18.00 -67,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,750 3,750 13.88 52,050 52,050
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -173 100 -63.37 18.00 -3,114 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 173 273 173.00 5.93 1,026 1,619
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,500 100 -96.15 18.00 -45,000 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,500 2,600 2,500.00 16.32 40,800 42,432
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,166 100 -97.66 18.00 -74,988 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,166 4,266 4,166.00 9.77 40,702 41,679
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,750 100 -97.40 18.00 -67,500 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,750 3,850 3,750.00 13.88 52,050 53,438
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,727 174 -95.54
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,726 174 -95.54
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,726 174 -95.54
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,727 0 -100.00 18.00 -67,086
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,727 3,727 5.93 22,101 22,101
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,726 0 -100.00 18.00 -67,068
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,726 0 -100.00 18.00 -67,068
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,726 3,726 5.93 22,095 22,095
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,726 3,726 5.93 22,095 22,095
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -6,667 0 -100.00
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -6,667 0 -100.00
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -266 3,901 -6.38
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -266 3,901 -6.38
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -6,666 0 -100.00
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -268 3,899 -6.43
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,667 0 -100.00 18.01 -120,052
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,667 0 -100.00 18.01 -120,052
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,667 6,667 5.17 34,468 34,468
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,667 6,667 5.17 34,468 34,468
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -266 0 -100.00 18.01 -4,790
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -266 0 -100.00 18.01 -4,790
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 266 266 5.93 1,577 1,577
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 266 266 5.93 1,577 1,577
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,666 100 -98.52 18.01 -120,034 1,801
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,666 6,766 6,666.00 5.17 34,463 34,980
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -268 100 -72.83 18.01 -4,826 1,801
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 268 368 268.00 5.93 1,589 2,182
2012-07-03 2012-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 11,250 11,250
2012-07-03 2012-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 2,500 2,500
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 2,500 2,500
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 3,750 3,750
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 3,750 3,750
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 2,500 2,500
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 3,750 3,750
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 4,166 4,166
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -3,750 11,250 -25.00
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -7,500 7,500 -50.00
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -11,250 3,750 -75.00
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -12,500 0 -100.00
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 6,667 6,667
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 6,667 6,667
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 4,166 4,166
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 6,666 6,666
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift -12,500 0 -100.00
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift -20,000 0 -100.00
2009-06-08 2009-06-04 4 PDLI PDL BIOPHARMA, INC.
Common Stock
A - Award 6,983 16,983 69.83 7.16 49,998 121,598
2007-09-10 2007-09-06 4 PDLI PDL BIOPHARMA, INC.
Commn Stock
P - Purchase X 500 1,500 50.00 20.12 10,060 30,180
2005-12-15 3 ISIS ISIS PHARMACEUTICALS INC
Common Stock
100
P
Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.
S
Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.
A
Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)
C
Konversi turunan
D
Penjualan atau pengalihan sekuritas kembali ke perusahaan.
F
Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.
G
Pemberian sekuritas oleh atau kepada orang dalam.
K
Swap ekuitas dan transaksi lindung nilai serupa
M
Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)
V
Transaksi yang dilaporkan secara sukarela pada Formulir 4.
J
Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)