IONS / Ionis Pharmaceuticals, Inc. - Insider Trading and Ownership Report - SEC Form 3, 4, 5

Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

Jumlah Saham Beredar 159,391,229 shares
Saham Orang Dalam1,424,259 shares
Kepemilikan oleh Orang Dalam0.89 %
Orang Dalam Sejati37
Skor Sentimen Orang Dalam

Skor Sentimen Orang Dalam mengidentifikasi perusahaan yang dibeli oleh orang dalam korporat.

Ini adalah hasil dari model kuantitatif multifaktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi internal tertinggi. Model penilaian ini menggunakan kombinasi dari jumlah bersih orang dalam yang membeli dalam 90 hari sebelumnya, total saham yang dibeli sebagai persentase dari jumlah saham yang beredar, dan total saham yang dimiliki oleh orang dalam. Angka tersebut berkisar dari 0 hingga 100, dengan angka yang lebih tinggi menunjukkan tingkat akumulasi yang lebih tinggi dibandingkan dengan perusahaan sejenis, dan 50 adalah rata-rata.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan akumulasi orang dalam tertinggi.

Skor Sentimen Petugas

Skor Sentimen Pejabat menemukan perusahaan yang dibeli oleh Pejabat Korporat.

Menurut definisi, Pejabat Korporasi adalah Orang Dalam Korporasi, tetapi tidak seperti beberapa Orang Dalam lainnya (Pemegang Saham 10% dan Anggota Dewan), Pejabat bekerja untuk perusahaan setiap hari, dan mereka menggunakan uang mereka sendiri saat bertransaksi . (Pemegang Saham 10% dan Anggota Dewan seringkali adalah manajer dana yang mengelola uang orang lain.) Dengan demikian, transaksi orang dalam yang dilakukan oleh Pejabat jauh lebih signifikan dan harus ditangani dengan tepat.

Seperti Skor Sentimen Internal, Skor Sentimen Pejabat adalah hasil dari model kuantitatif multi-faktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi pejabat tertinggi.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan sentimen orang dalam tertinggi.

Metrik Utama Orang Dalam

Kartu ini menunjukkan peringkat perusahaan berdasarkan berbagai metrik internal. Peringkat persentil menunjukkan bagaimana perusahaan ini dibandingkan dengan perusahaan lain di pasar AS. Peringkat yang lebih tinggi menunjukkan situasi yang lebih baik.

Sebagai contoh, secara umum diterima bahwa pembelian oleh orang dalam perusahaan adalah indikator positif, sehingga perusahaan dengan lebih banyak pembelian oleh orang dalam akan mendapat peringkat lebih tinggi daripada perusahaan dengan lebih sedikit pembelian oleh orang dalam (atau bahkan penjualan oleh orang dalam).

Jumlah Bersih Pembelian oleh Orang Dalam (Peringkat)

-13 ( )

11299 out of 11305

Jumlah Bersih Pembelian oleh Orang Dalam adalah total jumlah orang dalam yang membeli dikurangi total jumlah orang dalam yang menjual dalam 90 hari terakhir. Peringkat persentil ditunjukkan di sini (kisaran dari 0 hingga 100%).

Persentase Saham yang Dibeli oleh Orang Dalam (Peringkat)

-0.360 %( )

10869 out of 11224

Persentase Saham yang Dibeli oleh Orang Dalam adalah total jumlah saham yang dibeli oleh orang dalam dikurangi total jumlah saham yang dijual oleh orang dalam dalam 90 hari terakhir, dibagi dengan total jumlah saham yang beredar dan dikalikan dengan 100.

Grafik Perdagangan Orang Dalam

Grafik berikut menunjukkan Ionis Pharmaceuticals, Inc. transaksi orang dalam. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Secara umum, melakukan transaksi di perusahaan mereka berdasarkan informasi material yang belum dipublikasikan adalah ilegal bagi orang dalam. Ini tidak berarti bahwa mereka dilarang melakukan transaksi apa pun di perusahaan mereka sendiri. Namun, mereka wajib melaporkan semua transaksi kepada SEC melalui Formulir 4.

Daftar Orang Dalam dan Metrik Profitabilitas

Tabel ini menampilkan daftar orang dalam yang diketahui, dan dibuat secara otomatis dari pengajuan yang diungkapkan kepada SEC. Selain nama, jabatan terbaru, dan sebutan direktur, pejabat, atau pemilik 10%, kami memberikan kepemilikan terbaru yang diungkapkan. Selain itu, jika memungkinkan, kami memberikan kinerja perdagangan historis untuk orang dalam tersebut. Kinerja perdagangan historis adalah rata-rata tertimbang dari kinerja transaksi pembelian pasar terbuka aktual yang dilakukan oleh orang dalam tersebut. Untuk informasi lebih lanjut tentang bagaimana ini dihitung, tonton webinar YouTube ini.

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Orang Dalam Rata-rata Keuntungan (%) Saham
Dimiliki
Terbagi
Disesuaikan
C Frank Bennett EVP, Chief Scientific Officer - [O] 88,679 88,679
Spencer R Berthelsen Director - [D] 156,083 156,083
Joseph Baroldi EVP, Chief Business Officer - [O] 34,997 34,997
Brian Birchler EVP, Corp and Development Ops - [O] 56,826 56,826
Sarah Boyce Chief Business Officer - [O] 8,931 8,931
Stanley T Crooke Exec Chairman of the Board, Director - [D] [O] 2,021 2,021
Onaiza Cadoret-Manier EVP,Chf GL Pdt Str & Oper Ofc - [O] 35,788 35,788
Breaux Castleman Director - [D] 19,183 19,183
Devers Shannon L. EVP, Chief Human Resources Ofc - [O] 15,937 15,937
Richard D DiMarchi 10,000
Diaz Allene M. Director - [D] 18,368 18,368
David J Ecker Vice President - [O] 35,485 35,485
Orang Dalam Rata-rata Keuntungan (%) Saham
Dimiliki
Terbagi
Disesuaikan
Christopher Gabrieli 10,000
Richard S Geary EVP, Chief Development Officer - [O] 79,657 79,657
Joan E Herman Director - [D] 46,086 46,086
Elizabeth L Hougen EVP, Finance & CFO - [O] 110,500 110,500
Michael R Hayden Director - [D] 56,298 56,298
Jeffrey M Jonas Executive Vice President - [O] 0 0
Kyle Jenne EVP, Chf GL Pdt Str Ofcr - [O] 11,199 11,199
Joseph Iii Klein Director - [D] 16,446 16,446
Arthur A Levin Vice President - [O] 1,492 1,492
Joseph Loscalzo Director - [D] 36,330 36,330
Frederick T Muto Director - [D] 61,097 61,097
Damien McDevitt Chief Business Officer - [O] 2,573 2,573
Orang Dalam Rata-rata Keuntungan (%) Saham
Dimiliki
Terbagi
Disesuaikan
Brett P Monia Chief Executive Officer, Director - [D] [O] 180,009 180,009
O'neil Patrick R. EVP CLO & General Counsel - [O] 57,130 57,130
B Lynne Parshall Director - [D] 66,344 66,344
John C Reed Director - [D] 0 0
Peter N Reikes Director - [D] 14,222 14,222
Mark B Skaletsky 10,000
Aron Stein Vice President - [O] 1,536 1,536
Eugene Schneider EVP, Chf Clinical Develop Ofcr - [O] 51,507 51,507
Eric Swayze EVP Research - [O] 37,486 37,486
Joseph H Wender Director - [D] 108,835 108,835
Mark K Wedel VP & Chief Medical Officer - [O] 7,204 7,204
Kleanthis G Xanthopoulos President of Regulus - [O] 0 0
Yang Michael J. Director - [D] 6,010 6,010

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Rekam Jejak Pembelian Orang Dalam - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di IONS / Ionis Pharmaceuticals, Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Orang Dalam Dilaporkan
Saham
Dilaporkan
Harga
Disesuaikan
Saham
Disesuaikan
Harga
Dasar Biaya Hari-hari menuju
Maksimal
Harga di
Maksimal
Maksimal
Keuntungan ($)
Maksimum Pengembalian (%)
2025-05-01 Hayden Michael R 15,000 31.8600 15,000 31.8600 477,900 127 61.2300 440,550 92.18
2024-12-23 Hayden Michael R 2,500 36.1983 2,500 36.1983 90,496
2024-12-23 Hayden Michael R 2,500 36.2332 2,500 36.2332 90,583

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Rekam Jejak Penjualan Orang Dalam - Analisis Kerugian Jangka Pendek

Dalam bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan dalam pasar terbuka yang tidak direncanakan oleh orang dalam yang dilakukan di IONS / Ionis Pharmaceuticals, Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Orang Dalam Dilaporkan
Saham
Dilaporkan
Harga
Disesuaikan
Saham
Disesuaikan
Harga
Dasar Biaya Hari-hari menuju
Menit
Harga di
Menit
Kerugian Maksimal
Dihindari ($)
Kerugian Maksimal
Dihindari (%)
2025-04-16 Baroldi Joseph 3,928 28.4000 3,928 28.4000 111,555 0 28.3500 -196 -0.18
2025-04-16 Birchler Brian 680 28.3700 680 28.3700 19,292
2025-04-16 Jenne Kyle 3,016 28.3600 3,016 28.3600 85,534
2025-01-31 Geary Richard S 1,406 32.4049 1,406 32.4049 45,561
2025-01-31 HOUGEN ELIZABETH L 1,523 32.4384 1,523 32.4384 49,404
2025-01-31 BENNETT C FRANK 1,327 32.4636 1,327 32.4636 43,079
2025-01-31 Schneider Eugene 1,484 32.1967 1,484 32.1967 47,780
2025-01-31 O'NEIL PATRICK R. 1,406 32.4926 1,406 32.4926 45,685
2025-01-31 Monia Brett P 13,242 32.4464 13,242 32.4464 429,655

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Riwayat Transaksi

Klik ikon tautan untuk melihat riwayat transaksi lengkap. Transaksi yang dilaporkan sebagai bagian dari rencana perdagangan otomatis 10b5-1 akan memiliki tanda X di kolom yang bertanda 10b-5.

Berkas
Tanggal
Perdagangan
Tanggal
Formulir Orang Dalam Ticker Judul Keamanan Kode 10b5-1 Langsung Latihan
Harga
Satuan
Harga
Unit
Diubah
Nilai
Diubah (1 ribu)
Sisa
Pilihan
Sisa
Saham
2025-09-04 2025-09-02 4 Swayze Eric IONS Common Stock S - Sale D 53.6829 -1,130 -61 37,302
2025-09-04 2025-09-02 4 Swayze Eric IONS Common Stock S - Sale D 49.2200 -10,000 -492 38,432
2025-09-04 2025-09-03 4 WENDER JOSEPH H by Trust IONS Common Stock S - Sale I 60.1383 -11,200 -674 108,835
2025-09-04 2025-09-02 4 WENDER JOSEPH H by Trust IONS Common Stock S - Sale I 57.5311 -5,600 -322 120,035
2025-09-04 2025-09-02 4 WENDER JOSEPH H by Trust IONS Common Stock S - Sale I 55.0386 -11,200 -616 125,635
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock S - Sale D 61.0629 -59,699 -3,645 180,009
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock M - Exercise D 32.6000 27,568 899 239,708
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock M - Exercise D 32.6000 31,316 1,021 212,140
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock S - Sale D 60.1337 -127,500 -7,667 180,824
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock M - Exercise D 37.5800 42,030 1,579 308,324
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock S - Sale D 59.1190 -16,615 -982 266,294
2025-09-04 2025-09-03 4 Monia Brett P IONS Common Stock M - Exercise D 53.7700 102,900 5,533 282,909
2025-09-04 2025-09-02 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 51.4900 -9,250 -476 66,344
2025-09-04 2025-09-02 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 50.4200 -10,750 -542 75,594
2025-09-04 2025-09-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 60.0000 -28,000 -1,680 0
2025-09-04 2025-09-03 4 KLEIN JOSEPH III by Trust IONS Common Stock M - Exercise I 12,000 28,000
2025-09-04 2025-09-03 4 KLEIN JOSEPH III by Trust IONS Common Stock M - Exercise I 16,000 16,000
2025-09-04 2025-09-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 60.0000 -28,000 -1,680 0
2025-09-04 2025-09-03 4 KLEIN JOSEPH III by Trust IONS Common Stock M - Exercise I 12,000 28,000
2025-09-04 2025-09-03 4 KLEIN JOSEPH III by Trust IONS Common Stock M - Exercise I 16,000 16,000
2025-09-04 2025-09-03 4 Devers Shannon L. IONS Common Stock M - Exercise D 32.6000 928 30 15,937
2025-09-04 2025-09-03 4 Devers Shannon L. IONS Common Stock S - Sale D 61.0192 -3,162 -193 15,009
2025-09-04 2025-09-03 4 Devers Shannon L. IONS Common Stock M - Exercise D 37.5800 2,234 84 18,171
2025-09-04 2025-09-02 4 Geary Richard S IONS Common Stock S - Sale D 50.3671 -10,000 -504 79,657
2025-09-04 2025-09-03 4 Baroldi Joseph IONS Common Stock M - Exercise D 31.8000 15,000 477 31,926
2025-09-04 2025-09-03 4 Baroldi Joseph IONS Common Stock S - Sale D 59.0864 -30,000 -1,773 16,926
2025-09-04 2025-09-03 4 Baroldi Joseph IONS Common Stock M - Exercise D 31.8000 15,000 477 46,926
2025-09-04 2025-09-03 4 Baroldi Joseph IONS Common Stock S - Sale D 62.0101 -2,800 -174 31,926
2025-09-04 2025-09-03 4 Baroldi Joseph IONS Common Stock M - Exercise D 31.8000 2,800 89 34,726
2025-09-04 2025-09-03 4 WENDER JOSEPH H by Trust IONS Common Stock S - Sale I 60.1383 -11,200 -674 108,835
2025-09-04 2025-09-02 4 WENDER JOSEPH H by Trust IONS Common Stock S - Sale I 57.5311 -5,600 -322 120,035
2025-09-04 2025-09-02 4 WENDER JOSEPH H by Trust IONS Common Stock S - Sale I 55.0386 -11,200 -616 125,635
2025-09-04 2025-09-03 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 53.7700 49,800 2,678 57,130
2025-09-04 2025-09-03 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 61.4200 -11,375 -699 7,330
2025-09-04 2025-09-03 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 32.6000 13,050 425 18,705
2025-09-04 2025-09-03 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 60.8900 -65,475 -3,987 5,655
2025-09-04 2025-09-03 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 37.5800 14,000 526 71,130
2025-09-04 2025-09-02 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 54.5148 -13,050 -711 57,130
2025-09-04 2025-09-02 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 32.6000 13,050 425 70,180
2025-09-04 2025-09-03 4 BENNETT C FRANK IONS Common Stock M - Exercise D 61.5000 -12,891 -793 88,679
2025-09-04 2025-09-03 4 BENNETT C FRANK IONS Common Stock S - Sale D 60.6200 -33,909 -2,056 101,570
2025-09-04 2025-09-03 4 BENNETT C FRANK IONS Common Stock M - Exercise D 53.7700 46,800 2,516 135,479
2025-09-04 2025-09-02 4 BENNETT C FRANK IONS Common Stock S - Sale D 49.1400 -5,000 -246 88,679
2025-09-04 2025-09-03 4 Schneider Eugene IONS Common Stock S - Sale D 61.4163 -7,203 -442 51,507
2025-09-04 2025-09-03 4 Schneider Eugene IONS Common Stock S - Sale D 60.4608 -12,455 -753 58,710
2025-09-04 2025-09-03 4 Schneider Eugene IONS Common Stock M - Exercise D 53.7700 19,658 1,057 71,165
2025-09-04 2025-09-03 4 LOSCALZO JOSEPH IONS Common Stock S - Sale D 60.1482 -16,000 -962 36,330
2025-09-04 2025-09-03 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 24.4200 16,000 391 52,330
2025-09-03 2025-08-29 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 27.7100 331 9 57,130
2025-09-03 2025-08-29 4 Monia Brett P IONS Common Stock J - Other D 27.7100 189 5 180,009
2025-09-03 2025-08-29 4 BENNETT C FRANK IONS Common Stock J - Other D 27.7100 213 6 93,679
2025-09-03 2025-08-29 4 Geary Richard S IONS Common Stock J - Other D 27.7100 165 5 89,657
2025-09-03 2025-08-29 4 Birchler Brian IONS Common Stock J - Other D 27.7100 166 5 56,826
2025-08-26 2025-08-22 4 Diaz Allene M. IONS Common Stock S - Sale D 42.5278 -1,427 -61 18,368
2025-08-20 2025-08-18 4 BENNETT C FRANK IONS Common Stock S - Sale D 43.9776 -10,000 -440 93,466
2025-08-20 2025-08-18 4 BENNETT C FRANK IONS Common Stock M - Exercise D 32.6000 10,000 326 103,466
2025-08-08 2025-08-06 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 42.6275 -400 -17 86,344
2025-08-08 2025-08-06 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 41.8685 -4,600 -193 86,744
2025-08-06 2025-08-05 4 Geary Richard S IONS Common Stock S - Sale D 42.8593 -10,000 -429 89,492
2025-08-05 2025-08-04 4 Schneider Eugene IONS Common Stock S - Sale D 42.8004 -9,549 -409 51,507
2025-08-01 2025-07-30 4 Monia Brett P IONS Common Stock S - Sale D 45.0000 -2,432 -109 179,820
2025-08-01 2025-07-30 4 Monia Brett P IONS Common Stock M - Exercise D 32.6000 2,432 79 182,252
2025-07-17 2025-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 4,079 36,330
2025-07-17 2025-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 4,079 91,344
2025-07-17 2025-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 4,079 136,835
2025-07-17 2025-07-15 4 YANG MICHAEL J. IONS Common Stock M - Exercise D 4,079 6,010
2025-07-17 2025-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 4,079 156,013
2025-07-17 2025-07-15 4 Diaz Allene M. IONS Common Stock M - Exercise D 4,079 19,795
2025-07-17 2025-07-15 4 Hayden Michael R IONS Common Stock M - Exercise D 4,079 54,298
2025-07-17 2025-07-15 4 HERMAN JOAN E IONS Common Stock M - Exercise D 4,079 46,086
2025-07-15 2025-07-11 4 Monia Brett P IONS Common Stock S - Sale D 41.7381 -1,160 -48 179,820
2025-05-02 2025-05-01 4 Hayden Michael R IONS Common Stock P - Purchase D 31.8600 15,000 478 50,219
2025-04-17 2025-04-16 4 Baroldi Joseph IONS Common Stock S - Sale D 28.4000 -3,928 -112 31,926
2025-04-17 2025-04-15 4 Baroldi Joseph IONS Common Stock M - Exercise D 10,837 35,854
2025-04-17 2025-04-16 4 Jenne Kyle IONS Common Stock S - Sale D 28.3600 -3,016 -86 11,199
2025-04-17 2025-04-15 4 Jenne Kyle IONS Common Stock M - Exercise D 12,226 14,215
2025-04-17 2025-04-16 4 Birchler Brian IONS Common Stock S - Sale D 28.3700 -680 -19 56,660
2025-04-17 2025-04-15 4 Birchler Brian IONS Common Stock M - Exercise D 1,875 57,340
2025-03-13 2025-03-11 4 Monia Brett P IONS Common Stock S - Sale D 32.3200 -140 -5 180,980
2025-03-04 2025-02-28 4 Monia Brett P IONS Common Stock J - Other D 28.2115 437 12 181,120
2025-03-04 2025-02-28 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 28.2115 554 16 56,799
2025-03-04 2025-02-28 4 Swayze Eric IONS Common Stock J - Other D 28.2115 415 12 48,432
2025-03-04 2025-02-28 4 BENNETT C FRANK IONS Common Stock J - Other D 28.2115 320 9 93,466
2025-03-04 2025-02-28 4 Birchler Brian IONS Common Stock J - Other D 28.2115 414 12 55,465
2025-03-04 2025-02-28 4 Geary Richard S IONS Common Stock J - Other D 28.2115 415 12 99,492
2025-02-24 2025-02-20 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 32.3500 -1,207 -39 56,245
2025-02-06 2025-02-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 31.6203 -6,165 -195 57,452
2025-02-06 2025-02-04 4 Monia Brett P IONS Common Stock S - Sale D 31.6521 -38,843 -1,229 180,683
2025-02-03 2025-01-31 4 Schneider Eugene IONS Common Stock S - Sale D 32.1967 -1,484 -48 61,056
2025-02-03 2025-01-30 4 Schneider Eugene IONS Common Stock A - Award D 4,032 62,540
2025-02-03 2025-01-31 4 Swayze Eric IONS Common Stock S - Sale D 32.3058 -1,367 -44 48,017
2025-02-03 2025-01-30 4 Swayze Eric IONS Common Stock A - Award D 3,714 49,384
2025-02-03 2025-01-31 4 BENNETT C FRANK IONS Common Stock S - Sale D 32.4636 -1,327 -43 93,146
2025-02-03 2025-01-30 4 BENNETT C FRANK IONS Common Stock A - Award D 3,607 94,473
2025-02-03 2025-01-31 4 Geary Richard S IONS Common Stock S - Sale D 32.4049 -1,406 -46 99,077
2025-02-03 2025-01-30 4 Geary Richard S IONS Common Stock A - Award D 3,820 100,483
2025-02-03 2025-01-31 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 32.4384 -1,523 -49 110,500
2025-02-03 2025-01-30 4 HOUGEN ELIZABETH L IONS Common Stock A - Award D 4,138 112,023
2025-02-03 2025-01-31 4 Monia Brett P IONS Common Stock S - Sale D 32.4464 -13,242 -430 219,526
2025-02-03 2025-01-30 4 Monia Brett P IONS Common Stock A - Award D 25,372 232,768
2025-02-03 2025-01-31 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 32.4926 -1,406 -46 63,617
2025-02-03 2025-01-30 4 O'NEIL PATRICK R. IONS Common Stock A - Award D 3,820 65,023
2025-01-17 2025-01-16 4 Swayze Eric by Son IONS Common Stock S - Sale I 32.7000 -22 -1 184
2025-01-17 2025-01-16 4 Swayze Eric IONS Common Stock S - Sale D 32.8430 -7,154 -235 45,670
2025-01-17 2025-01-15 4 Swayze Eric by Son IONS Common Stock M - Exercise I 49 206
2025-01-17 2025-01-15 4 Swayze Eric IONS Common Stock M - Exercise D 19,111 52,824
2025-01-17 2025-01-16 4 Monia Brett P IONS Common Stock S - Sale D 32.6340 -33,445 -1,091 207,396
2025-01-17 2025-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 73,448 240,841
2025-01-17 2025-01-16 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 32.8300 -7,360 -242 61,203
2025-01-17 2025-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 19,690 68,563
2025-01-17 2025-01-15 4 YANG MICHAEL J. IONS Common Stock M - Exercise D 1,931 1,931
2025-01-17 2025-01-16 4 Schneider Eugene IONS Common Stock S - Sale D 32.7900 -6,523 -214 58,508
2025-01-17 2025-01-15 4 Schneider Eugene IONS Common Stock M - Exercise D 17,372 65,031
2025-01-17 2025-01-16 4 Baroldi Joseph by Spouse IONS Common Stock S - Sale I 32.7000 -1,029 -34 3,071
2025-01-17 2025-01-16 4 Baroldi Joseph IONS Common Stock S - Sale D 32.7000 -3,401 -111 25,017
2025-01-17 2025-01-15 4 Baroldi Joseph by Spouse IONS Common Stock M - Exercise I 2,460 4,100
2025-01-17 2025-01-15 4 Baroldi Joseph IONS Common Stock M - Exercise D 8,787 28,418
2025-01-17 2025-01-16 4 BENNETT C FRANK IONS Common Stock S - Sale D 32.8960 -6,752 -222 90,866
2025-01-17 2025-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 18,011 97,618
2025-01-17 2025-01-16 4 Birchler Brian IONS Common Stock S - Sale D 32.7000 -5,400 -177 55,051
2025-01-17 2025-01-15 4 Birchler Brian IONS Common Stock M - Exercise D 14,283 60,451
2025-01-17 2025-01-16 4 Geary Richard S IONS Common Stock S - Sale D 32.8630 -7,072 -232 96,663
2025-01-17 2025-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 18,901 103,735
2025-01-17 2025-01-16 4 Devers Shannon L. IONS Common Stock S - Sale D 32.7760 -4,267 -140 15,937
2025-01-17 2025-01-15 4 Devers Shannon L. IONS Common Stock M - Exercise D 12,295 20,204
2025-01-17 2025-01-16 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 32.8060 -8,870 -291 107,885
2025-01-17 2025-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 23,887 116,755
2024-12-26 2024-12-23 4 Hayden Michael R IONS Common Stock P - Purchase D 36.2332 2,500 91 35,219
2024-12-26 2024-12-23 4 Hayden Michael R IONS Common Stock P - Purchase D 36.1983 2,500 90 32,719
2024-11-14 2024-11-12 4 LOSCALZO JOSEPH IONS Common Stock S - Sale D 37.8610 -13,508 -511 32,251
2024-11-14 2024-11-12 4 Monia Brett P IONS Common Stock S - Sale D 38.0534 -6,630 -252 167,393
2024-11-14 2024-11-12 4 Swayze Eric IONS Common Stock S - Sale D 37.9210 -1,194 -45 33,713
2024-10-17 2024-10-16 4 Swayze Eric by Son IONS Common Stock S - Sale I 38.3130 -53 -2 157
2024-10-17 2024-10-15 4 Swayze Eric by Son IONS Common Stock M - Exercise I 125 210
2024-10-01 3 Devers Shannon L. IONS Common Stock D 7,909
2024-09-04 2024-08-30 4 Swayze Eric IONS Common Stock J - Other D 38.6410 11 0 34,907
2024-09-04 2024-08-30 4 Monia Brett P IONS Common Stock J - Other D 38.6410 140 5 174,023
2024-09-04 2024-08-30 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 38.6410 246 10 48,873
2024-09-04 2024-08-30 4 BENNETT C FRANK IONS Common Stock J - Other D 38.6410 177 7 79,607
2024-09-04 2024-08-30 4 Birchler Brian IONS Common Stock J - Other D 38.6410 12 0 46,168
2024-09-04 2024-08-30 4 Geary Richard S IONS Common Stock J - Other D 38.6410 11 0 84,834
2024-09-04 2024-02-02 4/A Geary Richard S IONS Common Stock S - Sale D 50.0433 -1,995 -100 87,300
2024-09-04 2024-02-02 4/A HOUGEN ELIZABETH L IONS Common Stock S - Sale D 49.5399 -2,162 -107 92,868
2024-09-04 2024-02-02 4/A O'NEIL PATRICK R. IONS Common Stock S - Sale D 49.6738 -1,995 -99 48,627
2024-09-04 2024-02-02 4/A Schneider Eugene IONS Common Stock S - Sale D 49.5900 -2,106 -104 47,659
2024-09-04 2024-02-02 4/A Swayze Eric IONS Common Stock S - Sale D 49.5613 -1,940 -96 34,291
2024-09-04 2024-02-02 4/A Monia Brett P IONS Common Stock S - Sale D 49.3725 -23,907 -1,180 173,732
2024-09-04 2024-02-02 4/A Monia Brett P IONS Common Stock S - Sale D 49.3725 -23,907 -1,180 173,732
2024-09-04 2024-02-02 4/A BENNETT C FRANK IONS Common Stock S - Sale D 49.5156 -1,885 -93 79,047
2024-09-04 2024-02-02 4/A Cadoret-Manier Onaiza IONS Common Stock S - Sale D 49.6020 -2,162 -107 35,788
2024-09-03 2024-08-29 4 Geary Richard S IONS Common Stock S - Sale D 49.6300 -331 -16 84,823
2024-09-03 2024-08-28 4 Geary Richard S IONS Common Stock S - Sale D 49.1600 -320 -16 85,154
2024-08-06 2024-08-05 4 Geary Richard S IONS Common Stock S - Sale D 48.0000 -2,430 -117 85,508
2024-07-17 2024-07-16 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 50.0000 -12,000 -600 0
2024-07-17 2024-07-16 4 KLEIN JOSEPH III by Trust IONS Common Stock M - Exercise I 24.4200 12,000 293 12,000
2024-07-17 2024-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 4,677 45,759
2024-07-17 2024-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 4,677 132,756
2024-07-17 2024-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 4,677 87,265
2024-07-17 2024-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 4,677 151,934
2024-07-17 2024-07-15 4 HERMAN JOAN E IONS Common Stock M - Exercise D 4,677 42,007
2024-07-17 2024-07-16 4 Diaz Allene M. IONS Common Stock S - Sale D 50.1700 -737 -37 15,716
2024-07-17 2024-07-16 4 Diaz Allene M. IONS Common Stock S - Sale D 48.9379 -900 -44 16,453
2024-07-17 2024-07-15 4 Diaz Allene M. IONS Common Stock M - Exercise D 4,677 17,353
2024-06-20 2024-06-17 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 40.2900 -16,000 -645 147,257
2024-06-20 2024-06-17 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 35.5300 16,000 568 163,257
2024-05-13 2024-05-09 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 35.5300 16,000 568 128,079
2024-05-07 2024-05-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 42.8957 -930 -40 0
2024-05-07 2024-05-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 42.5473 -1,070 -46 930
2024-05-07 2024-05-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 42.9767 -731 -31 2,000
2024-05-07 2024-05-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 42.5875 -1,269 -54 2,731
2024-05-07 2024-05-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 42.9449 -682 -29 4,000
2024-05-07 2024-05-03 4 KLEIN JOSEPH III by Trust IONS Common Stock S - Sale I 42.5721 -1,318 -56 4,682
2024-04-17 2024-04-16 4 Baroldi Joseph IONS Common Stock S - Sale D 41.5978 -4,006 -167 19,631
2024-04-17 2024-04-15 4 Baroldi Joseph IONS Common Stock M - Exercise D 10,838 23,637
2024-04-17 2024-04-16 4 Birchler Brian IONS Common Stock S - Sale D 41.6555 -905 -38 46,156
2024-04-17 2024-04-15 4 Birchler Brian IONS Common Stock M - Exercise D 1,875 47,061
2024-03-13 3 Jenne Kyle IONS Common Stock D 1,989
2024-03-04 2024-02-29 4 Monia Brett P IONS Common Stock J - Other D 34.4250 538 19 174,289
2024-03-04 2024-02-29 4 Birchler Brian IONS Common Stock J - Other D 34.4250 604 21 45,186
2024-03-04 2024-02-29 4 Geary Richard S IONS Common Stock J - Other D 34.4250 604 21 87,938
2024-03-04 2024-02-29 4 Swayze Eric IONS Common Stock J - Other D 34.4250 605 21 34,929
2024-03-04 2024-02-29 4 BENNETT C FRANK IONS Common Stock J - Other D 34.4250 383 13 79,462
2024-02-16 2024-02-16 4 Monia Brett P IONS Common Stock S - Sale D 44.4924 -387 -17 173,751
2024-02-02 2024-02-02 4 Swayze Eric IONS Common Stock S - Sale D 49.5613 -1,907 -95 34,324
2024-02-02 2024-02-01 4 Swayze Eric IONS Common Stock A - Award D 3,715 36,231
2024-02-02 2024-01-31 4 Swayze Eric IONS Common Stock S - Sale D 52.0000 -10,773 -560 32,516
2024-02-02 2024-02-02 4 BENNETT C FRANK IONS Common Stock S - Sale D 49.5156 -1,853 -92 79,079
2024-02-02 2024-02-01 4 BENNETT C FRANK IONS Common Stock A - Award D 3,609 80,932
2024-02-02 2024-02-02 4 Cadoret-Manier Onaiza IONS Common Stock S - Sale D 49.6020 -2,125 -105 35,825
2024-02-02 2024-02-01 4 Cadoret-Manier Onaiza IONS Common Stock A - Award D 4,140 37,950
2024-02-02 2024-02-02 4 Geary Richard S IONS Common Stock S - Sale D 50.0433 -1,961 -98 87,334
2024-02-02 2024-02-01 4 Geary Richard S IONS Common Stock A - Award D 3,820 89,295
2024-02-02 2024-02-02 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 49.5399 -2,125 -105 92,905
2024-02-02 2024-02-01 4 HOUGEN ELIZABETH L IONS Common Stock A - Award D 4,140 95,030
2024-02-02 2024-02-02 4 Monia Brett P IONS Common Stock S - Sale D 49.3725 -23,501 -1,160 174,138
2024-02-02 2024-02-01 4 Monia Brett P IONS Common Stock A - Award D 20,416 197,639
2024-02-02 2024-02-01 4 Monia Brett P IONS Common Stock A - Award D 25,372 177,223
2024-02-02 2024-02-02 4 Schneider Eugene IONS Common Stock S - Sale D 49.5900 -2,071 -103 49,812
2024-02-02 2024-02-01 4 Schneider Eugene IONS Common Stock A - Award D 4,033 51,883
2024-02-02 2024-02-02 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 49.6738 -1,961 -97 48,661
2024-02-02 2024-02-01 4 O'NEIL PATRICK R. IONS Common Stock A - Award D 3,820 50,622
2024-01-29 2024-01-25 4 Monia Brett P IONS Common Stock S - Sale D 51.7500 -2,285 -118 151,851
2024-01-29 2024-01-25 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 51.7500 -6,450 -334 46,802
2024-01-18 2024-01-17 4 Cadoret-Manier Onaiza IONS Common Stock S - Sale D 50.4170 -5,564 -281 33,810
2024-01-18 2024-01-16 4 Cadoret-Manier Onaiza IONS Common Stock M - Exercise D 15,062 39,374
2024-01-18 2024-01-17 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 50.4170 -7,744 -390 53,252
2024-01-18 2024-01-16 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 20,641 60,996
2024-01-18 2024-01-17 4 Birchler Brian IONS Common Stock S - Sale D 50.4170 -4,497 -227 44,582
2024-01-18 2024-01-16 4 Birchler Brian IONS Common Stock M - Exercise D 12,080 49,079
2024-01-18 2024-01-17 4 Swayze Eric by Son IONS Common Stock S - Sale I 50.4170 -9 -0 85
2024-01-18 2024-01-17 4 Swayze Eric IONS Common Stock S - Sale D 50.4170 -6,296 -317 43,289
2024-01-18 2024-01-16 4 Swayze Eric by Son IONS Common Stock M - Exercise I 21 94
2024-01-18 2024-01-16 4 Swayze Eric IONS Common Stock M - Exercise D 17,069 49,585
2024-01-18 2024-01-17 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 50.4170 -8,683 -438 90,890
2024-01-18 2024-01-16 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 22,487 99,573
2024-01-18 2024-01-17 4 Monia Brett P IONS Common Stock S - Sale D 50.4170 -32,059 -1,616 154,136
2024-01-18 2024-01-16 4 Monia Brett P IONS Common Stock M - Exercise D 68,084 186,195
2024-01-18 2024-01-17 4 Schneider Eugene IONS Common Stock S - Sale D 50.4170 -5,482 -276 47,850
2024-01-18 2024-01-16 4 Schneider Eugene IONS Common Stock M - Exercise D 15,162 53,332
2024-01-18 2024-01-17 4 Geary Richard S IONS Common Stock S - Sale D 50.4170 -7,338 -370 85,475
2024-01-18 2024-01-16 4 Geary Richard S IONS Common Stock M - Exercise D 19,852 92,813
2024-01-18 2024-01-17 4 Baroldi Joseph by Spouse IONS Common Stock S - Sale I 50.4170 -564 -28 1,640
2024-01-18 2024-01-17 4 Baroldi Joseph IONS Common Stock S - Sale D 50.4170 -1,460 -74 12,799
2024-01-18 2024-01-16 4 Baroldi Joseph by Spouse IONS Common Stock M - Exercise I 1,353 2,204
2024-01-18 2024-01-16 4 Baroldi Joseph IONS Common Stock M - Exercise D 3,688 14,259
2024-01-18 2024-01-17 4 BENNETT C FRANK IONS Common Stock S - Sale D 50.4170 -6,745 -340 77,323
2024-01-18 2024-01-16 4 BENNETT C FRANK IONS Common Stock M - Exercise D 18,314 84,068
2024-01-17 2024-01-12 4 Schneider Eugene IONS Common Stock S - Sale D 53.4999 -8,000 -428 38,170
2024-01-17 2024-01-12 4 Schneider Eugene IONS Common Stock M - Exercise D 32.6000 8,000 261 46,170
2024-01-02 2023-12-28 4 Swayze Eric IONS Common Stock S - Sale D 50.1875 -27,100 -1,360 32,516
2024-01-02 2023-12-28 4 Swayze Eric IONS Common Stock M - Exercise D 47.3400 27,100 1,283 59,616
2024-01-02 2023-12-28 4 Birchler Brian IONS Common Stock F - Taxes D 50.5000 -11,029 -557 36,999
2024-01-02 2023-12-28 4 Birchler Brian IONS Common Stock M - Exercise D 47.3400 11,500 544 48,028
2024-01-02 2023-12-28 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 50.5000 -43,798 -2,212 77,086
2024-01-02 2023-12-28 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 47.3400 45,225 2,141 120,884
2023-12-28 2023-12-28 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 50.1875 -42,525 -2,134 82,588
2023-12-28 2023-12-28 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 47.3400 42,525 2,013 125,113
2023-12-28 2023-12-27 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 50.2303 -50,000 -2,512 82,588
2023-12-28 2023-12-27 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 47.3400 50,000 2,367 132,588
2023-12-28 2023-12-26 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 51.4630 -25,113 -1,292 82,588
2023-12-28 2023-12-26 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 47.3400 25,113 1,189 107,701
2023-12-28 2023-12-26 4 Schneider Eugene IONS Common Stock S - Sale D 51.4630 -25,000 -1,287 36,052
2023-12-28 2023-12-26 4 Schneider Eugene IONS Common Stock M - Exercise D 47.3400 25,000 1,184 61,052
2023-12-28 2023-12-26 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 51.4630 -20,825 -1,072 40,355
2023-12-28 2023-12-26 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 47.3400 20,825 986 61,180
2023-12-22 2023-12-21 4 BENNETT C FRANK IONS Common Stock S - Sale D 49.2901 -16,113 -794 65,754
2023-12-22 2023-12-21 4 BENNETT C FRANK IONS Common Stock M - Exercise D 47.3400 16,113 763 81,867
2023-12-22 2023-12-20 4 BENNETT C FRANK IONS Common Stock S - Sale D 49.6374 -6,500 -323 65,754
2023-12-22 2023-12-20 4 BENNETT C FRANK IONS Common Stock M - Exercise D 47.3400 6,500 308 72,254
2023-12-22 2023-12-21 4 Geary Richard S IONS Common Stock S - Sale D 49.2901 -4,112 -203 72,961
2023-12-22 2023-12-21 4 Geary Richard S IONS Common Stock M - Exercise D 47.3400 4,112 195 77,073
2023-12-22 2023-12-20 4 Geary Richard S IONS Common Stock S - Sale D 49.6374 -6,500 -323 72,961
2023-12-22 2023-12-20 4 Geary Richard S IONS Common Stock M - Exercise D 47.3400 6,500 308 79,461
2023-12-22 2023-12-21 4 Monia Brett P IONS Common Stock S - Sale D 49.2901 -17,500 -863 118,111
2023-12-22 2023-12-21 4 Monia Brett P IONS Common Stock M - Exercise D 47.3400 17,500 828 135,611
2023-12-22 2023-12-20 4 Monia Brett P IONS Common Stock S - Sale D 49.6374 -6,500 -323 118,111
2023-12-22 2023-12-20 4 Monia Brett P IONS Common Stock M - Exercise D 47.3400 6,500 308 124,611
2023-12-18 2023-12-14 4 Monia Brett P IONS Common Stock S - Sale D 50.1870 -9,140 -459 118,111
2023-12-18 2023-12-14 4 Monia Brett P IONS Common Stock M - Exercise D 47.3400 9,140 433 127,251
2023-12-18 2023-12-14 4 Monia Brett P IONS Common Stock S - Sale D 49.2133 -14,860 -731 118,111
2023-12-18 2023-12-14 4 Monia Brett P IONS Common Stock M - Exercise D 47.3400 14,860 703 132,971
2023-12-18 2023-12-14 4 BENNETT C FRANK IONS Common Stock S - Sale D 50.1870 -8,610 -432 65,754
2023-12-18 2023-12-14 4 BENNETT C FRANK IONS Common Stock M - Exercise D 47.3400 8,610 408 74,364
2023-12-18 2023-12-14 4 BENNETT C FRANK IONS Common Stock S - Sale D 49.2133 -14,002 -689 65,754
2023-12-18 2023-12-14 4 BENNETT C FRANK IONS Common Stock M - Exercise D 47.3400 14,002 663 79,756
2023-12-18 2023-12-14 4 Geary Richard S IONS Common Stock S - Sale D 50.1870 -4,042 -203 72,961
2023-12-18 2023-12-14 4 Geary Richard S IONS Common Stock M - Exercise D 47.3400 4,042 191 77,003
2023-12-18 2023-12-14 4 Geary Richard S IONS Common Stock S - Sale D 49.2133 -6,571 -323 72,961
2023-12-18 2023-12-14 4 Geary Richard S IONS Common Stock M - Exercise D 47.3400 6,571 311 79,532
2023-11-17 2023-11-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 50.0000 -2,000 -100 16,346
2023-10-18 2023-10-17 4 Swayze Eric by Son IONS Common Stock S - Sale I 47.9490 -52 -2 73
2023-10-18 2023-10-16 4 Swayze Eric by Son IONS Common Stock M - Exercise I 125 125
2023-10-16 2023-10-12 4 Monia Brett P IONS Common Stock S - Sale D 46.0000 -3,770 -173 118,111
2023-09-29 2023-09-28 4 BENNETT C FRANK IONS Common Stock S - Sale D 46.5000 -4,460 -207 65,754
2023-09-28 2023-09-26 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 45.1268 -2,000 -90 18,346
2023-09-28 2023-09-26 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 45.1268 -10,000 -451 82,588
2023-09-05 2023-08-31 4 Geary Richard S IONS Common Stock J - Other D 30.5575 1 0 72,961
2023-09-05 2023-08-31 4 Monia Brett P IONS Common Stock J - Other D 30.5575 157 5 121,881
2023-09-05 2023-08-31 4 BENNETT C FRANK IONS Common Stock J - Other D 30.5575 180 6 70,214
2023-08-03 2023-08-01 4 Diaz Allene M. IONS Common Stock S - Sale D 41.0500 -657 -27 12,676
2023-07-19 2023-07-17 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 5,333 112,079
2023-07-19 2023-07-17 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 1,777 106,746
2023-07-19 2023-07-17 4 HERMAN JOAN E IONS Common Stock M - Exercise D 5,333 37,330
2023-07-19 2023-07-17 4 HERMAN JOAN E IONS Common Stock M - Exercise D 1,777 31,997
2023-07-19 2023-07-17 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 5,333 41,082
2023-07-19 2023-07-17 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 1,777 35,749
2023-07-19 2023-07-17 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 5,333 92,588
2023-07-19 2023-07-17 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 1,777 87,255
2023-07-19 2023-07-18 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 42.0000 -3,555 -149 20,346
2023-07-19 2023-07-17 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 5,333 23,901
2023-07-19 2023-07-17 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 1,777 18,568
2023-07-19 2023-07-17 4 Hayden Michael R IONS Common Stock M - Exercise D 5,333 30,219
2023-07-19 2023-07-17 4 Hayden Michael R IONS Common Stock M - Exercise D 1,777 24,886
2023-07-19 2023-07-17 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 5,333 147,257
2023-07-19 2023-07-17 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 1,777 141,924
2023-07-19 2023-07-17 4 Diaz Allene M. IONS Common Stock M - Exercise D 5,333 13,333
2023-07-11 2023-07-07 4 Monia Brett P IONS Common Stock S - Sale D 42.2495 -18,650 -788 121,724
2023-06-22 2023-06-20 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 28.4700 11,250 320 140,147
2023-06-14 2023-06-12 4 HERMAN JOAN E IONS Common Stock M - Exercise D 3,555 30,220
2023-05-24 2023-05-22 4 Monia Brett P IONS Common Stock S - Sale D 40.1400 -2,630 -106 140,374
2023-05-24 2023-05-22 4 Monia Brett P IONS Common Stock S - Sale D 40.1300 -2,301 -92 143,004
2023-05-24 2023-05-24 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 41.7000 -1,527 -64 40,355
2023-04-19 2023-04-18 4 Baroldi Joseph IONS Common Stock S - Sale D 36.5028 -3,880 -142 10,571
2023-04-19 2023-04-17 4 Baroldi Joseph IONS Common Stock M - Exercise D 10,838 14,451
2023-04-19 2023-04-18 4 Cadoret-Manier Onaiza IONS Common Stock S - Sale D 36.5026 -2,582 -94 24,312
2023-04-19 2023-04-17 4 Cadoret-Manier Onaiza IONS Common Stock M - Exercise D 5,667 26,894
2023-04-19 2023-04-18 4 Birchler Brian IONS Common Stock S - Sale D 36.5024 -672 -25 36,528
2023-04-19 2023-04-17 4 Birchler Brian IONS Common Stock M - Exercise D 1,875 37,200
2023-04-19 3/A Schneider Eugene IONS Common Stock D 13,224
2023-03-24 3 Birchler Brian IONS Common Stock D 35,325
2023-03-02 2023-02-28 4 BENNETT C FRANK IONS Common Stock J - Other D 30.5150 383 12 70,034
2023-03-02 2023-02-28 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 30.5150 163 5 75,659
2023-03-02 2023-02-28 4 Geary Richard S IONS Common Stock J - Other D 30.5150 575 18 72,960
2023-03-02 2023-02-28 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 30.5150 301 9 41,882
2023-03-02 2023-02-28 4 Swayze Eric IONS Common Stock J - Other D 30.5150 575 18 32,516
2023-02-07 2023-02-06 4 Swayze Eric IONS Common Stock S - Sale D 40.7886 -1,815 -74 31,941
2023-02-07 2023-02-03 4 Swayze Eric IONS Common Stock A - Award D 3,715 33,756
2023-02-07 2023-02-06 4 Cadoret-Manier Onaiza IONS Common Stock S - Sale D 40.6595 -1,451 -59 21,227
2023-02-07 2023-02-03 4 Cadoret-Manier Onaiza IONS Common Stock A - Award D 4,140 22,678
2023-02-07 2023-02-06 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 40.8648 -1,920 -78 41,581
2023-02-07 2023-02-03 4 O'NEIL PATRICK R. IONS Common Stock A - Award D 3,822 43,501
2023-02-07 2023-02-06 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 40.5927 -2,079 -84 75,496
2023-02-07 2023-02-03 4 HOUGEN ELIZABETH L IONS Common Stock A - Award D 4,140 77,575
2023-02-07 2023-02-06 4 Geary Richard S IONS Common Stock S - Sale D 40.6615 -1,920 -78 72,385
2023-02-07 2023-02-03 4 Geary Richard S IONS Common Stock A - Award D 3,822 74,305
2023-02-07 2023-02-06 4 Schneider Eugene IONS Common Stock S - Sale D 40.6682 -1,413 -57 24,946
2023-02-07 2023-02-03 4 Schneider Eugene IONS Common Stock A - Award D 4,033 26,359
2023-02-07 2023-02-06 4 Monia Brett P IONS Common Stock S - Sale D 40.6942 -24,651 -1,003 145,305
2023-02-07 2023-02-03 4 Monia Brett P IONS Common Stock A - Award D 25,372 169,956
2023-02-07 2023-02-03 4 Monia Brett P IONS Common Stock A - Award D 17,210 144,584
2023-02-07 2023-02-03 4 Monia Brett P IONS Common Stock A - Award D 6,511 127,374
2023-02-07 2023-02-06 4 BENNETT C FRANK IONS Common Stock S - Sale D 40.5738 -1,813 -74 69,651
2023-02-07 2023-02-03 4 BENNETT C FRANK IONS Common Stock A - Award D 3,609 71,464
2023-02-02 2023-01-31 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 39.7111 -4,500 -179 39,679
2023-02-02 2023-01-30 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 39.4160 -4,500 -177 44,179
2023-01-19 2023-01-18 4 Schneider Eugene IONS Common Stock S - Sale D 39.5732 -4,752 -188 22,326
2023-01-19 2023-01-17 4 Schneider Eugene IONS Common Stock M - Exercise D 13,046 27,078
2023-01-19 2023-01-18 4 Swayze Eric IONS Common Stock S - Sale D 39.7442 -5,631 -224 30,041
2023-01-19 2023-01-17 4 Swayze Eric IONS Common Stock M - Exercise D 15,780 35,672
2023-01-19 2023-01-18 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 39.4946 -7,836 -309 48,679
2023-01-19 2023-01-17 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 21,871 56,515
2023-01-19 2023-01-18 4 Monia Brett P IONS Common Stock S - Sale D 39.4936 -25,066 -990 120,863
2023-01-19 2023-01-17 4 Monia Brett P IONS Common Stock M - Exercise D 57,267 145,929
2023-01-19 2023-01-18 4 Baroldi Joseph by Spouse IONS Common Stock S - Sale I 39.7868 -375 -15 851
2023-01-19 2023-01-17 4 Baroldi Joseph by Spouse IONS Common Stock M - Exercise I 904 1,226
2023-01-19 2023-01-18 4 BENNETT C FRANK IONS Common Stock S - Sale D 38.8874 -6,978 -271 67,855
2023-01-19 2023-01-17 4 BENNETT C FRANK IONS Common Stock M - Exercise D 19,417 74,833
2023-01-19 2023-01-18 4 Geary Richard S IONS Common Stock S - Sale D 39.5688 -7,873 -312 70,483
2023-01-19 2023-01-17 4 Geary Richard S IONS Common Stock M - Exercise D 21,983 78,356
2023-01-19 2023-01-18 4 Cadoret-Manier Onaiza IONS Common Stock S - Sale D 39.5473 -3,748 -148 18,538
2023-01-19 2023-01-17 4 Cadoret-Manier Onaiza IONS Common Stock M - Exercise D 10,197 22,286
2023-01-19 2023-01-18 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 39.7006 -8,280 -329 73,435
2023-01-19 2023-01-17 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 23,154 81,715
2023-01-18 2023-01-17 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 40.0000 -2,000 -80 16,791
2022-10-18 2022-10-17 4 Schneider Eugene IONS Common Stock F - Taxes D 46.5200 -144 -7 14,032
2022-10-18 2022-10-17 4 Schneider Eugene IONS Common Stock M - Exercise D 416 14,176
2022-10-18 2022-10-17 4 Hayden Michael R IONS Common Stock M - Exercise D 1,777 23,109
2022-09-12 2022-09-08 4 Swayze Eric IONS Common Stock S - Sale D 44.5500 -460 -20 19,892
2022-09-01 2022-08-31 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 28.9680 108 3 34,644
2022-09-01 2022-08-31 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 28.9680 202 6 58,561
2022-09-01 2022-08-31 4 BENNETT C FRANK IONS Common Stock J - Other D 28.9680 183 5 55,416
2022-08-09 2022-08-05 4 Swayze Eric IONS Common Stock S - Sale D 45.2000 -1 -0 20,352
2022-07-19 2022-07-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 38.7800 -644 -25 18,791
2022-07-19 2022-07-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 37.7400 -689 -26 19,435
2022-07-19 2022-07-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 2,665 20,124
2022-07-19 2022-07-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 5,333 17,459
2022-07-19 2022-07-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 2,665 59,597
2022-07-19 2022-07-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 5,333 56,932
2022-07-19 2022-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 2,665 85,478
2022-07-19 2022-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 5,333 82,813
2022-07-19 2022-07-15 4 HERMAN JOAN E IONS Common Stock M - Exercise D 1,777 26,665
2022-07-19 2022-07-15 4 HERMAN JOAN E IONS Common Stock M - Exercise D 5,333 24,888
2022-07-19 2022-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 2,665 104,969
2022-07-19 2022-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 5,333 102,304
2022-07-19 2022-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 2,665 33,972
2022-07-19 2022-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 5,333 31,307
2022-07-19 2022-07-15 4 Hayden Michael R IONS Common Stock M - Exercise D 1,777 21,332
2022-07-19 2022-07-15 4 Hayden Michael R IONS Common Stock M - Exercise D 5,333 19,555
2022-07-19 2022-07-15 4 Diaz Allene M. IONS Common Stock M - Exercise D 8,000 8,000
2022-07-19 2022-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 2,665 128,897
2022-07-19 2022-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 5,333 126,232
2022-07-06 2022-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 12.9400 11,250 146 51,599
2022-06-14 2022-06-10 4 HERMAN JOAN E IONS Common Stock M - Exercise D 3,555 19,555
2022-06-09 2022-06-07 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 12.9400 11,250 146 120,899
2022-04-25 2022-04-21 4 Swayze Eric IONS Common Stock S - Sale D 44.1500 -378 -17 20,353
2022-04-19 2022-04-18 4 Cadoret-Manier Onaiza IONS Restricted Stock Unit M - Exercise D 0.00 -5,667 46,063
2022-04-19 2022-04-18 4 Cadoret-Manier Onaiza IONS Common Stock F - Taxes D 41.0100 -1,960 -80 12,089
2022-04-19 2022-04-18 4 Cadoret-Manier Onaiza IONS Common Stock M - Exercise D 5,667 14,049
2022-04-19 2022-04-15 4 Baroldi Joseph IONS Restricted Stock Unit A - Award D 43,350 43,350
2022-04-14 2022-04-12 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 40.0555 -6,792 -272 34,536
2022-04-05 2022-04-01 4 Monia Brett P IONS Common Stock S - Sale D 37.4901 -355 -13 88,662
2022-03-02 2022-02-28 4 Swayze Eric IONS Common Stock J - Other D 28.3730 621 18 20,731
2022-03-02 2022-02-28 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 28.3730 384 11 58,359
2022-03-02 2022-02-28 4 Monia Brett P IONS Common Stock J - Other D 28.3730 621 18 89,017
2022-03-02 2022-02-28 4 Geary Richard S IONS Common Stock J - Other D 28.3730 621 18 56,373
2022-03-02 2022-02-28 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 28.3730 735 21 41,328
2022-03-02 2022-02-28 4 BENNETT C FRANK IONS Common Stock J - Other D 28.3730 346 10 55,233
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Non-Qualified Stock Option (right to buy) G - Gift I 64.80 8,000 8,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Non-Qualified Stock Option (right to buy) G - Gift I 24.42 12,000 12,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Non-Qualified Stock Option (right to buy) G - Gift I 60.20 12,000 12,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Non-Qualified Stock Option (right to buy) G - Gift I 52.22 16,000 16,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Non-Qualified Stock Option (right to buy) G - Gift I 57.16 16,000 16,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Non-Qualified Stock Option (right to buy) G - Gift I 42.88 12,000 12,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) G - Gift D 64.80 -8,000 8,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) G - Gift D 60.20 -12,000 0
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) G - Gift D 24.42 -12,000 0
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) G - Gift D 52.22 -16,000 0
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) G - Gift D 57.16 -16,000 0
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) G - Gift D 42.88 -12,000 4,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III by Trust IONS Common Stock G - Gift I 6,000 6,000
2022-02-14 2021-11-30 5 KLEIN JOSEPH III IONS Common Stock G - Gift D -6,000 12,126
2022-02-02 3 Baroldi Joseph IONS Common Stock D 3,613
2022-02-02 3 Baroldi Joseph by Spouse IONS Common Stock I 322
2022-02-02 2022-01-31 4 Baroldi Joseph IONS Non-Qualified Stock Option (right to buy) A - Award D 31.80 86,700 86,700
2022-01-28 2022-01-26 4 Monia Brett P IONS Common Stock F - Taxes D 31.4400 -8,032 -253 88,396
2022-01-28 2022-01-26 4 Monia Brett P IONS Common Stock A - Award D 14,004 96,428
2022-01-28 2022-01-26 4 Monia Brett P IONS Common Stock A - Award D 2,194 82,424
2022-01-20 2022-01-18 4 Cadoret-Manier Onaiza IONS Restricted Stock Unit M - Exercise D 0.00 -6,057 51,730
2022-01-20 2022-01-18 4 Cadoret-Manier Onaiza IONS Common Stock F - Taxes D 30.1200 -2,305 -69 8,382
2022-01-20 2022-01-18 4 Cadoret-Manier Onaiza IONS Common Stock M - Exercise D 6,057 10,687
2022-01-20 2022-01-18 4 PARSHALL B LYNNE IONS Restricted Stock Unit M - Exercise D 0.00 -5,754 9,775
2022-01-20 2022-01-18 4 PARSHALL B LYNNE IONS Common Stock F - Taxes D 30.1200 -1,652 -50 77,480
2022-01-20 2022-01-18 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 5,754 79,132
2022-01-20 2022-01-18 4 BENNETT C FRANK IONS Restricted Stock Unit M - Exercise D 0.00 -18,842 24,444
2022-01-20 2022-01-18 4 BENNETT C FRANK IONS Common Stock F - Taxes D 30.1200 -6,726 -203 54,887
2022-01-20 2022-01-18 4 BENNETT C FRANK IONS Common Stock M - Exercise D 18,842 61,613
2022-01-20 2022-01-18 4 O'NEIL PATRICK R. IONS Restricted Stock Unit M - Exercise D 0.00 -21,086 52,319
2022-01-20 2022-01-18 4 O'NEIL PATRICK R. IONS Common Stock F - Taxes D 30.1200 -7,501 -226 40,593
2022-01-20 2022-01-18 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 21,086 48,094
2022-01-20 2022-01-18 4 Monia Brett P IONS Restricted Stock Unit M - Exercise D 0.00 -49,475 145,123
2022-01-20 2022-01-18 4 Monia Brett P IONS Common Stock F - Taxes D 30.1200 -19,714 -594 80,230
2022-01-20 2022-01-18 4 Monia Brett P IONS Common Stock M - Exercise D 49,475 99,944
2022-01-20 2022-01-18 4 HOUGEN ELIZABETH L IONS Restricted Stock Unit M - Exercise D 0.00 -22,050 55,837
2022-01-20 2022-01-18 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 30.1200 -7,828 -236 57,975
2022-01-20 2022-01-18 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 22,050 65,803
2022-01-20 2022-01-18 4 Swayze Eric IONS Restricted Stock Unit M - Exercise D 0.00 -13,809 41,970
2022-01-20 2022-01-18 4 Swayze Eric IONS Common Stock F - Taxes D 30.1200 -4,994 -150 20,110
2022-01-20 2022-01-18 4 Swayze Eric IONS Common Stock M - Exercise D 13,809 25,104
2022-01-20 2022-01-18 4 Schneider Eugene IONS Restricted Stock Unit M - Exercise D 0.00 -10,400 36,325
2022-01-20 2022-01-18 4 Schneider Eugene IONS Common Stock F - Taxes D 30.1200 -3,815 -115 13,760
2022-01-20 2022-01-18 4 Schneider Eugene IONS Common Stock M - Exercise D 10,400 17,575
2022-01-20 2022-01-18 4 Geary Richard S IONS Restricted Stock Unit M - Exercise D 0.00 -21,391 50,853
2022-01-20 2022-01-18 4 Geary Richard S IONS Common Stock F - Taxes D 30.1200 -7,605 -229 55,752
2022-01-20 2022-01-18 4 Geary Richard S IONS Common Stock M - Exercise D 21,391 63,357
2022-01-19 2022-01-15 4 Schneider Eugene IONS Restricted Stock Unit A - Award D 0.00 16,133 46,725
2022-01-19 2022-01-15 4 Schneider Eugene IONS Performance Restricted Stock Units A - Award D 0.00 12,099 12,099
2022-01-19 2022-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Unit A - Award D 0.00 15,284 73,405
2022-01-19 2022-01-15 4 O'NEIL PATRICK R. IONS Performance Restricted Stock Units A - Award D 0.00 11,463 11,463
2022-01-19 2022-01-15 4 Swayze Eric IONS Restricted Stock Unit A - Award D 0.00 14,859 55,779
2022-01-19 2022-01-15 4 Swayze Eric IONS Performance Restricted Stock Units A - Award D 0.00 11,144 11,144
2022-01-19 2022-01-15 4 BENNETT C FRANK IONS Restricted Stock Unit A - Award D 0.00 14,435 43,286
2022-01-19 2022-01-15 4 BENNETT C FRANK IONS Performance Restricted Stock Units A - Award D 0.00 10,826 10,826
2022-01-19 2022-01-15 4 Cadoret-Manier Onaiza IONS Restricted Stock Unit A - Award D 0.00 16,559 57,787
2022-01-19 2022-01-15 4 Cadoret-Manier Onaiza IONS Performance Restricted Stock Units A - Award D 0.00 12,419 12,419
2022-01-19 2022-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Unit A - Award D 0.00 16,559 77,887
2022-01-19 2022-01-15 4 HOUGEN ELIZABETH L IONS Performance Restricted Stock Units A - Award D 0.00 12,419 12,419
2022-01-19 2022-01-15 4 Geary Richard S IONS Restricted Stock Unit A - Award D 0.00 15,284 72,244
2022-01-19 2022-01-15 4 Geary Richard S IONS Performance Restricted Stock Units A - Award D 0.00 11,463 11,463
2022-01-19 2022-01-15 4 Monia Brett P IONS Restricted Stock Unit A - Award D 0.00 50,745 194,598
2022-01-19 2022-01-15 4 Monia Brett P IONS Performance Restricted Stock Units A - Award D 0.00 76,117 170,573
2022-01-05 2022-01-03 4 Swayze Eric IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 29,718 29,718
2022-01-05 2022-01-03 4 HOUGEN ELIZABETH L IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 33,118 33,118
2022-01-05 2022-01-03 4 Cadoret-Manier Onaiza IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 33,118 33,118
2022-01-05 2022-01-03 4 Monia Brett P IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 101,489 101,489
2022-01-05 2022-01-03 4 Geary Richard S IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 30,567 30,567
2022-01-05 2022-01-03 4 Schneider Eugene IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 32,265 32,265
2022-01-05 2022-01-03 4 O'NEIL PATRICK R. IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 30,567 30,567
2022-01-05 2022-01-03 4 BENNETT C FRANK IONS Non-Qualified Stock Option (right to buy) A - Award D 32.60 28,869 28,869
2021-10-19 2021-10-15 4 Reikes Peter N IONS Restricted Stock Unit M - Exercise D 0.00 -1,777 10,664
2021-10-19 2021-10-15 4 Reikes Peter N IONS Common Stock M - Exercise D 1,777 14,222
2021-10-19 2021-10-15 4 Schneider Eugene IONS Restricted Stock Unit M - Exercise D 0.00 -417 30,592
2021-10-19 2021-10-15 4 Schneider Eugene IONS Common Stock F - Taxes D 35.1000 -145 -5 7,175
2021-10-19 2021-10-15 4 Schneider Eugene IONS Common Stock M - Exercise D 417 7,320
2021-10-19 2021-10-15 4 Hayden Michael R IONS Restricted Stock Unit M - Exercise D 0.00 -1,777 10,664
2021-10-19 2021-10-15 4 Hayden Michael R IONS Common Stock M - Exercise D 1,777 14,222
2021-09-02 2021-08-31 4 Geary Richard S IONS Common Stock J - Other D 33.7960 46 2 41,966
2021-09-02 2021-08-31 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 33.7960 309 10 27,008
2021-09-02 2021-08-31 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 33.7960 166 6 43,753
2021-09-02 2021-08-31 4 Monia Brett P IONS Common Stock J - Other D 33.7960 355 12 50,469
2021-09-02 2021-08-31 4 BENNETT C FRANK IONS Common Stock J - Other D 33.7960 151 5 42,771
2021-09-02 2021-08-31 4 Cadoret-Manier Onaiza IONS Common Stock J - Other D 33.7960 431 15 4,630
2021-07-19 2021-07-15 4 Reikes Peter N IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 12,441
2021-07-19 2021-07-15 4 Reikes Peter N IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 14,219
2021-07-19 2021-07-15 4 Reikes Peter N IONS Common Stock M - Exercise D 1,778 12,445
2021-07-19 2021-07-15 4 Reikes Peter N IONS Common Stock M - Exercise D 5,333 10,667
2021-07-19 2021-07-15 4 PARSHALL B LYNNE IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 15,529
2021-07-19 2021-07-15 4 PARSHALL B LYNNE IONS Restricted Stock Unit M - Exercise D 0.00 -889 17,307
2021-07-19 2021-07-15 4 PARSHALL B LYNNE IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 18,196
2021-07-19 2021-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 1,778 73,378
2021-07-19 2021-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 889 71,600
2021-07-19 2021-07-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 5,333 70,711
2021-07-19 2021-07-15 4 WENDER JOSEPH H IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 9,775
2021-07-19 2021-07-15 4 WENDER JOSEPH H IONS Restricted Stock Unit M - Exercise D 0.00 -666 11,553
2021-07-19 2021-07-15 4 WENDER JOSEPH H IONS Restricted Stock Unit M - Exercise D 0.00 -889 12,219
2021-07-19 2021-07-15 4 WENDER JOSEPH H IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 13,108
2021-07-19 2021-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 1,778 96,971
2021-07-19 2021-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 666 95,193
2021-07-19 2021-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 889 94,527
2021-07-19 2021-07-15 4 WENDER JOSEPH H by Trust IONS Common Stock M - Exercise I 5,333 93,638
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 9,775
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Restricted Stock Unit M - Exercise D 0.00 -666 11,553
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Restricted Stock Unit M - Exercise D 0.00 -889 12,219
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 13,108
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 1,778 40,349
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 666 38,571
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 889 37,905
2021-07-19 2021-07-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 5,333 37,016
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 9,775
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Restricted Stock Unit M - Exercise D 0.00 -666 11,553
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Restricted Stock Unit M - Exercise D 0.00 -889 12,219
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 13,108
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 35.2998 -4,334 -153 18,126
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 1,778 22,460
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 666 20,682
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 889 20,016
2021-07-19 2021-07-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 5,333 19,127
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 9,775
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Restricted Stock Unit M - Exercise D 0.00 -666 11,553
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Restricted Stock Unit M - Exercise D 0.00 -889 12,219
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 13,108
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 1,778 25,974
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 666 24,196
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 889 23,530
2021-07-19 2021-07-15 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 5,333 22,641
2021-07-19 2021-07-15 4 Hayden Michael R IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 12,441
2021-07-19 2021-07-15 4 Hayden Michael R IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 14,219
2021-07-19 2021-07-15 4 Hayden Michael R IONS Common Stock M - Exercise D 1,778 12,445
2021-07-19 2021-07-15 4 Hayden Michael R IONS Common Stock M - Exercise D 5,333 10,667
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 9,775
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Restricted Stock Unit M - Exercise D 0.00 -666 11,553
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Restricted Stock Unit M - Exercise D 0.00 -889 12,219
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 13,108
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 1,778 109,649
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 666 107,871
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 889 107,205
2021-07-19 2021-07-15 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 5,333 106,316
2021-07-19 2021-07-15 4 Diaz Allene M. IONS Restricted Stock Unit A - Award D 0.00 8,000 8,000
2021-07-19 2021-07-15 4 HERMAN JOAN E IONS Restricted Stock Unit M - Exercise D 0.00 -1,778 15,997
2021-07-19 2021-07-15 4 HERMAN JOAN E IONS Restricted Stock Unit M - Exercise D 0.00 -5,333 17,775
2021-07-19 2021-07-15 4 HERMAN JOAN E IONS Common Stock M - Exercise D 1,778 16,000
2021-07-19 2021-07-15 4 HERMAN JOAN E IONS Common Stock M - Exercise D 5,333 14,222
2021-07-06 2021-07-01 4 WENDER JOSEPH H IONS Restricted Stock Unit A - Award D 0.00 5,333 18,441
2021-07-06 2021-07-01 4 WENDER JOSEPH H IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 Diaz Allene M. IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 18,000 18,000
2021-07-06 2021-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Unit A - Award D 0.00 5,333 18,441
2021-07-06 2021-07-01 4 KLEIN JOSEPH III IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 MUTO FREDERICK T IONS Restricted Stock Unit A - Award D 0.00 5,333 18,441
2021-07-06 2021-07-01 4 MUTO FREDERICK T IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 PARSHALL B LYNNE IONS Restricted Stock Unit A - Award D 0.00 5,333 23,529
2021-07-06 2021-07-01 4 PARSHALL B LYNNE IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Unit A - Award D 0.00 5,333 18,441
2021-07-06 2021-07-01 4 LOSCALZO JOSEPH IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 Reikes Peter N IONS Restricted Stock Unit A - Award D 0.00 5,333 19,552
2021-07-06 2021-07-01 4 Reikes Peter N IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Unit A - Award D 0.00 5,333 18,441
2021-07-06 2021-07-01 4 BERTHELSEN SPENCER R IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 Hayden Michael R IONS Restricted Stock Unit A - Award D 0.00 5,333 19,552
2021-07-06 2021-07-01 4 Hayden Michael R IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-07-06 2021-07-01 4 HERMAN JOAN E IONS Restricted Stock Unit A - Award D 0.00 5,333 23,108
2021-07-06 2021-07-01 4 HERMAN JOAN E IONS Non-Qualified Stock Option (right to buy) A - Award D 40.05 12,000 12,000
2021-06-25 2021-06-23 4 BERTHELSEN SPENCER R IONS Non-Qualified Stock Option (right to buy) M - Exercise D 9.30 -15,000 0
2021-06-25 2021-06-23 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 37.7400 -15,000 -566 100,983
2021-06-25 2021-06-23 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 9.3000 15,000 140 115,983
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Non-Qualified Stock Option (right to buy) M - Exercise D 9.30 -5,000 0
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Non-Qualified Stock Option (right to buy) M - Exercise D 9.30 -5,000 0
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Non-Qualified Stock Option (right to buy) M - Exercise D 9.30 -5,000 5,000
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Common Stock S - Sale D 36.8500 -5,000 -184 31,683
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 9.3000 5,000 46 36,683
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 9.3000 5,000 46 36,683
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Common Stock S - Sale D 36.5500 -5,000 -183 31,683
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 9.3000 5,000 46 36,683
2021-06-17 2021-06-15 4 MUTO FREDERICK T IONS Common Stock S - Sale D 36.5000 -5,000 -182 31,683
2021-06-14 2021-06-10 4 HERMAN JOAN E IONS Restricted Stock Unit M - Exercise D -3,555 17,775
2021-06-14 2021-06-10 4 HERMAN JOAN E IONS Common Stock M - Exercise D 3,555 8,889
2021-04-19 2021-04-15 4 Cadoret-Manier Onaiza IONS Restricted Stock Unit M - Exercise D 0.00 -5,667 17,000
2021-04-19 2021-04-15 4 Cadoret-Manier Onaiza IONS Common Stock F - Taxes D 41.0300 -1,960 -80 4,199
2021-04-19 2021-04-15 4 Cadoret-Manier Onaiza IONS Common Stock M - Exercise D 5,667 6,159
2021-03-02 2021-02-26 4 Swayze Eric IONS Common Stock J - Other D 44.5400 460 20 11,295
2021-03-02 2021-02-26 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 44.5400 197 9 26,699
2021-03-02 2021-02-26 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 44.5400 116 5 43,587
2021-03-02 2021-02-26 4 Geary Richard S IONS Common Stock J - Other D 44.5400 414 18 41,920
2021-03-02 2021-02-26 4 Cadoret-Manier Onaiza IONS Common Stock J - Other D 44.5400 492 22 492
2021-03-02 2021-02-26 4 BENNETT C FRANK IONS Common Stock J - Other D 44.5400 112 5 42,620
2021-03-02 2021-03-01 4 Monia Brett P IONS Common Stock S - Sale D 54.2750 -236 -13 50,114
2021-03-02 2021-02-26 4 Monia Brett P IONS Common Stock J - Other D 44.5400 247 11 50,350
2021-02-01 2021-01-28 4 Monia Brett P IONS Common Stock F - Taxes D 60.6900 -1,306 -79 50,103
2021-02-01 2021-01-28 4 Monia Brett P IONS Common Stock A - Award D 2,634 51,409
2021-01-28 2021-01-26 4 CROOKE STANLEY T IONS Common Stock S - Sale D 63.7353 -28,333 -1,806 2,021
2021-01-27 2021-01-25 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 63.5000 -5,324 -338 26,502
2021-01-25 2021-01-22 4 CROOKE STANLEY T By trust IONS Common Stock S - Sale I 61.6750 -40,000 -2,467 494,391
2021-01-25 2021-01-21 4 CROOKE STANLEY T By trust IONS Common Stock S - Sale I 61.6500 -21,042 -1,297 534,391
2021-01-25 2021-01-21 4 CROOKE STANLEY T By trust IONS Common Stock S - Sale I 60.5300 -13,958 -845 555,433
2021-01-20 2021-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -4,371 7,801
2021-01-20 2021-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -47,257 87,885
2021-01-20 2021-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units A - Award D 5,333 5,333
2021-01-20 2021-01-15 4 CROOKE STANLEY T By wife IONS Common Stock F - Taxes I 61.2800 -1,434 -88 3,111
2021-01-20 2021-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 4,371 4,545
2021-01-20 2021-01-15 4 CROOKE STANLEY T IONS Common Stock F - Taxes D 61.2800 -18,924 -1,160 30,354
2021-01-20 2021-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 47,257 49,278
2021-01-20 2021-01-15 4 Cadoret-Manier Onaiza IONS Restricted Stock Units A - Award D 24,228 24,228
2021-01-20 2021-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -15,520 29,641
2021-01-20 2021-01-15 4 BENNETT C FRANK IONS Restricted Stock Units A - Award D 20,822 20,822
2021-01-20 2021-01-15 4 BENNETT C FRANK IONS Common Stock F - Taxes D 61.2800 -5,488 -336 42,508
2021-01-20 2021-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 15,520 47,996
2021-01-20 2021-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -17,598 34,246
2021-01-20 2021-01-15 4 Geary Richard S IONS Restricted Stock Units A - Award D 22,714 22,714
2021-01-20 2021-01-15 4 Geary Richard S IONS Common Stock F - Taxes D 61.2800 -6,398 -392 41,506
2021-01-20 2021-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 17,598 47,904
2021-01-20 2021-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -17,151 34,199
2021-01-20 2021-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units A - Award D 27,129 27,129
2021-01-20 2021-01-15 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 61.2800 -6,175 -378 43,471
2021-01-20 2021-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 17,151 49,646
2021-01-20 2021-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -34,823 77,243
2021-01-20 2021-01-15 4 Monia Brett P IONS Performance Restricted Stock Units A - Award D 77,447 77,447
2021-01-20 2021-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 66,610 66,610
2021-01-20 2021-01-15 4 Monia Brett P IONS Common Stock F - Taxes D 61.2800 -14,927 -915 48,775
2021-01-20 2021-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 34,823 63,702
2021-01-20 2021-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -16,504 32,253
2021-01-20 2021-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units A - Award D 25,868 25,868
2021-01-20 2021-01-15 4 O'NEIL PATRICK R. IONS Common Stock F - Taxes D 61.2800 -5,856 -359 31,826
2021-01-20 2021-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 16,504 37,682
2021-01-20 2021-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -10,655 5,754
2021-01-20 2021-01-15 4 PARSHALL B LYNNE IONS Common Stock F - Taxes D 61.2800 -2,741 -168 65,378
2021-01-20 2021-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 10,655 68,119
2021-01-20 2021-01-15 4 Schneider Eugene IONS Restricted Stock Units M - Exercise D -7,503 15,256
2021-01-20 2021-01-15 4 Schneider Eugene IONS Restricted Stock Units A - Award D 15,753 15,753
2021-01-20 2021-01-15 4 Schneider Eugene IONS Common Stock F - Taxes D 61.2800 -2,718 -167 6,903
2021-01-20 2021-01-15 4 Schneider Eugene IONS Common Stock M - Exercise D 7,503 9,621
2021-01-20 2021-01-15 4 Swayze Eric IONS Restricted Stock Units M - Exercise D -8,944 16,944
2021-01-20 2021-01-15 4 Swayze Eric IONS Restricted Stock Units A - Award D 23,976 23,976
2021-01-20 2021-01-15 4 Swayze Eric IONS Common Stock F - Taxes D 61.2800 -3,216 -197 10,835
2021-01-20 2021-01-15 4 Swayze Eric IONS Common Stock M - Exercise D 8,944 14,051
2021-01-15 2021-01-13 4 Geary Richard S IONS Common Stock S - Sale D 59.5000 -141 -8 30,306
2021-01-06 2020-11-19 5 CROOKE STANLEY T By trust IONS Common Stock G - Gift I -31,000 569,391
2021-01-06 2021-01-04 4 Schneider Eugene IONS Employee Stock Option (right to buy) A - Award D 56.78 35,444 35,444
2021-01-06 3 Schneider Eugene IONS Common Stock D 2,118
2021-01-06 2021-01-05 4 Swayze Eric IONS Common Stock S - Sale D 55.9900 -195 -11 5,107
2021-01-06 2021-01-04 4 Swayze Eric IONS Employee Stock Option (right to buy) A - Award D 56.78 53,945 53,945
2021-01-06 2021-01-04 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) A - Award D 56.78 12,000 12,000
2021-01-06 2021-01-04 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 56.78 149,872 149,872
2021-01-06 2021-01-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) A - Award D 56.78 58,203 58,203
2021-01-06 2021-01-04 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) A - Award D 56.78 61,041 61,041
2021-01-06 2021-01-04 4 Geary Richard S IONS Employee Stock Option (right to buy) A - Award D 56.78 51,107 51,107
2021-01-06 2021-01-04 4 Cadoret-Manier Onaiza IONS Employee Stock Option (right to buy) A - Award D 56.78 54,513 54,513
2021-01-06 2021-01-04 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) A - Award D 56.78 46,850 46,850
2020-12-28 2020-12-23 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 60.0000 -10,000 -600 57,464
2020-12-17 2020-12-17 4 CROOKE STANLEY T by wife IONS Common Stock S - Sale I 50.5000 -1,407 -71 174
2020-12-17 2020-12-15 4 CROOKE STANLEY T by trust IONS Common Stock S - Sale I 49.7750 -39,000 -1,941 600,391
2020-12-09 2020-12-07 4 CROOKE STANLEY T by trust IONS Common Stock S - Sale I 51.5000 -6,000 -309 639,391
2020-12-09 2020-12-07 4 CROOKE STANLEY T by trust IONS Common Stock S - Sale I 51.8701 -5,000 -259 645,391
2020-12-08 2020-12-04 4 Monia Brett P IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -23,840 0
2020-12-08 2020-12-04 4 Monia Brett P IONS Common Stock S - Sale D 51.0400 -23,840 -1,217 28,879
2020-12-08 2020-12-04 4 Monia Brett P IONS Common Stock M - Exercise D 39.8700 23,840 951 52,719
2020-12-08 2020-12-04 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -7,947 0
2020-12-08 2020-12-04 4 BENNETT C FRANK IONS Common Stock S - Sale D 51.0400 -7,947 -406 32,476
2020-12-08 2020-12-04 4 BENNETT C FRANK IONS Common Stock M - Exercise D 39.8700 7,947 317 40,423
2020-12-04 2020-12-02 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -7,053 7,947
2020-12-04 2020-12-02 4 BENNETT C FRANK IONS Common Stock S - Sale D 51.3200 -7,053 -362 32,476
2020-12-04 2020-12-02 4 BENNETT C FRANK IONS Common Stock M - Exercise D 39.8700 7,053 281 39,529
2020-12-04 2020-12-02 4 Monia Brett P IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -21,160 23,840
2020-12-04 2020-12-02 4 Monia Brett P IONS Common Stock S - Sale D 51.3200 -21,160 -1,086 28,879
2020-12-04 2020-12-02 4 Monia Brett P IONS Common Stock M - Exercise D 39.8700 21,160 844 50,039
2020-11-30 2020-11-25 4 HOUGEN ELIZABETH L IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -21,680 0
2020-11-30 2020-11-25 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 50.0500 -21,680 -1,085 32,495
2020-11-30 2020-11-25 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 39.8700 21,680 864 54,175
2020-11-30 2020-11-25 4 CROOKE STANLEY T IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -12,990 0
2020-11-30 2020-11-25 4 CROOKE STANLEY T IONS Common Stock S - Sale D 50.0500 -12,990 -650 2,021
2020-11-30 2020-11-25 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 12,990 518 15,011
2020-11-30 2020-11-25 4 PARSHALL B LYNNE IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -3,590 0
2020-11-30 2020-11-25 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 50.0500 -3,590 -180 67,464
2020-11-30 2020-11-25 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 3,590 143 71,054
2020-11-30 2020-11-25 4 Geary Richard S IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -11,920 0
2020-11-30 2020-11-25 4 Geary Richard S IONS Common Stock S - Sale D 50.0500 -11,920 -597 30,447
2020-11-30 2020-11-25 4 Geary Richard S IONS Common Stock M - Exercise D 39.8700 11,920 475 42,367
2020-11-25 2020-11-24 4 CROOKE STANLEY T IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -2,590 12,990
2020-11-25 2020-11-24 4 CROOKE STANLEY T IONS Common Stock S - Sale D 50.8300 -2,590 -132 2,021
2020-11-25 2020-11-24 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 2,590 103 4,611
2020-11-25 2020-11-23 4 CROOKE STANLEY T IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -11,600 15,580
2020-11-25 2020-11-23 4 CROOKE STANLEY T by wife IONS Non-Qualified Stock Option (right to buy) M - Exercise I 39.87 -500 0
2020-11-25 2020-11-23 4 CROOKE STANLEY T IONS Common Stock S - Sale D 50.1100 -11,600 -581 2,021
2020-11-25 2020-11-23 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 11,600 462 13,621
2020-11-25 2020-11-23 4 CROOKE STANLEY T by wife IONS Common Stock S - Sale I 50.0000 -500 -25 1,581
2020-11-25 2020-11-23 4 CROOKE STANLEY T by wife IONS Common Stock M - Exercise I 39.8700 500 20 2,081
2020-11-25 2020-11-24 4 HOUGEN ELIZABETH L IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -4,320 21,680
2020-11-25 2020-11-24 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 50.8300 -4,320 -220 32,495
2020-11-25 2020-11-24 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 39.8700 4,320 172 36,815
2020-11-25 2020-11-23 4 HOUGEN ELIZABETH L IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -5,875 26,000
2020-11-25 2020-11-23 4 HOUGEN ELIZABETH L IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -13,125 31,875
2020-11-25 2020-11-23 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 50.1100 -5,875 -294 32,495
2020-11-25 2020-11-23 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 39.8700 5,875 234 38,370
2020-11-25 2020-11-23 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 50.1100 -13,125 -658 32,495
2020-11-25 2020-11-23 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 39.8700 13,125 523 45,620
2020-11-25 2020-11-24 4 Geary Richard S IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -2,380 11,920
2020-11-25 2020-11-24 4 Geary Richard S IONS Common Stock S - Sale D 50.8300 -2,380 -121 30,447
2020-11-25 2020-11-24 4 Geary Richard S IONS Common Stock M - Exercise D 39.8700 2,380 95 32,827
2020-11-25 2020-11-23 4 Geary Richard S IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -10,700 14,300
2020-11-25 2020-11-23 4 Geary Richard S IONS Common Stock S - Sale D 50.1100 -10,700 -536 30,447
2020-11-25 2020-11-23 4 Geary Richard S IONS Common Stock M - Exercise D 39.8700 10,700 427 41,147
2020-11-25 2020-11-24 4 PARSHALL B LYNNE IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -710 3,590
2020-11-25 2020-11-24 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 50.8200 -710 -36 67,464
2020-11-25 2020-11-24 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 710 28 68,174
2020-11-25 2020-11-23 4 PARSHALL B LYNNE IONS Non-Qualified Stock Option (right to buy) M - Exercise D 39.87 -3,200 4,300
2020-11-25 2020-11-23 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 50.1200 -3,200 -160 67,464
2020-11-25 2020-11-23 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 3,200 128 70,664
2020-11-05 2020-11-03 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -15,000 15,000
2020-11-05 2020-11-03 4 BENNETT C FRANK IONS Common Stock S - Sale D 46.7733 -15,000 -702 32,476
2020-11-05 2020-11-03 4 BENNETT C FRANK IONS Common Stock M - Exercise D 39.8700 15,000 598 47,476
2020-10-22 2020-10-20 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 46.8625 -2,889 -135 13,794
2020-10-19 2020-10-15 4 Hayden Michael R IONS Restricted Stock Units M - Exercise D -1,778 3,554
2020-10-19 2020-10-15 4 Hayden Michael R IONS Common Stock M - Exercise D 1,778 5,334
2020-10-19 2020-10-15 4 Reikes Peter N IONS Restricted Stock Units M - Exercise D -1,778 3,554
2020-10-19 2020-10-15 4 Reikes Peter N IONS Common Stock M - Exercise D 1,778 5,334
2020-09-23 2020-09-22 4 CROOKE STANLEY T By trust IONS Common Stock S - Sale I 50.4092 -50,000 -2,520 650,391
2020-09-23 2020-09-21 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 50.1800 -2,000 -100 1,581
2020-09-18 2020-09-16 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) M - Exercise D 28.47 -11,250 0
2020-09-18 2020-09-16 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) M - Exercise D 12.94 -11,250 0
2020-09-18 2020-09-16 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 28.4700 11,250 320 88,305
2020-09-18 2020-09-16 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 12.9400 11,250 146 77,055
2020-09-02 2020-08-31 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 44.4550 169 8 21,178
2020-09-02 2020-08-31 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 44.4550 121 5 32,495
2020-09-02 2020-08-31 4 Geary Richard S IONS Common Stock J - Other D 44.4550 1 0 30,447
2020-09-02 2020-08-31 4 BENNETT C FRANK IONS Common Stock J - Other D 44.4550 112 5 32,476
2020-09-02 2020-09-01 4 Monia Brett P IONS Common Stock S - Sale D 53.7000 -314 -17 28,879
2020-09-02 2020-08-31 4 Monia Brett P IONS Common Stock J - Other D 44.4550 236 10 29,193
2020-09-02 2020-08-31 4 Swayze Eric IONS Common Stock J - Other D 44.4550 1 0 5,302
2020-07-06 2020-07-01 4 Hayden Michael R IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 Hayden Michael R IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 Hayden Michael R IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 Hayden Michael R IONS Common Stock M - Exercise D 1,778 3,556
2020-07-06 2020-07-01 4 HERMAN JOAN E IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 HERMAN JOAN E IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 HERMAN JOAN E IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 HERMAN JOAN E IONS Common Stock M - Exercise D 1,778 5,334
2020-07-06 2020-07-06 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -667 666
2020-07-06 2020-07-06 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 667 17,308
2020-07-06 2020-07-02 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 889 16,641
2020-07-06 2020-07-01 4 LOSCALZO JOSEPH IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -666 0
2020-07-06 2020-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 1,778 15,752
2020-07-06 2020-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 666 13,974
2020-07-06 2020-07-02 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 889 67,464
2020-07-06 2020-07-01 4 PARSHALL B LYNNE IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 PARSHALL B LYNNE IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 1,778 66,575
2020-07-06 2020-07-06 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -667 666
2020-07-06 2020-07-06 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 667 16,683
2020-07-06 2020-07-02 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 889 16,016
2020-07-06 2020-07-01 4 KLEIN JOSEPH III IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -666 0
2020-07-06 2020-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 1,778 15,127
2020-07-06 2020-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 666 13,349
2020-07-06 2020-07-01 4 Reikes Peter N IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 Reikes Peter N IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 Reikes Peter N IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 Reikes Peter N IONS Common Stock M - Exercise D 1,778 3,556
2020-07-06 2020-07-06 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -667 666
2020-07-06 2020-07-06 4 Castleman Breaux IONS Common Stock M - Exercise D 667 19,183
2020-07-06 2020-07-02 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 Castleman Breaux IONS Common Stock M - Exercise D 889 18,516
2020-07-06 2020-07-01 4 Castleman Breaux IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 Castleman Breaux IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -666 0
2020-07-06 2020-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 1,778 17,627
2020-07-06 2020-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 666 15,849
2020-07-06 2020-07-06 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -667 666
2020-07-06 2020-07-06 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 667 65,805
2020-07-06 2020-07-02 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 889 65,138
2020-07-06 2020-07-01 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -666 0
2020-07-06 2020-07-01 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 1,778 64,249
2020-07-06 2020-07-01 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 666 62,471
2020-07-06 2020-07-06 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -667 666
2020-07-06 2020-07-06 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 667 31,683
2020-07-06 2020-07-02 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 889 31,016
2020-07-06 2020-07-01 4 MUTO FREDERICK T IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -666 0
2020-07-06 2020-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 1,778 30,127
2020-07-06 2020-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 666 28,349
2020-07-06 2020-07-06 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -667 666
2020-07-06 2020-07-06 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 667 100,983
2020-07-06 2020-07-02 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -889 1,777
2020-07-06 2020-07-02 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 889 100,316
2020-07-06 2020-07-01 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) A - Award D 60.20 12,000 12,000
2020-07-06 2020-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units A - Award D 0.00 5,333 5,333
2020-07-06 2020-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -1,778 5,332
2020-07-06 2020-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -666 0
2020-07-06 2020-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 1,778 99,427
2020-07-06 2020-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 666 97,649
2020-07-02 2020-06-30 4 MUTO FREDERICK T IONS Director Stock Option (right to buy) M - Exercise D 9.22 -15,000 0
2020-07-02 2020-06-30 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 9.2200 15,000 138 27,683
2020-06-29 2020-06-25 4 BENNETT C FRANK IONS Common Stock S - Sale D 59.7670 -15,000 -897 32,364
2020-06-29 2020-06-25 4 BENNETT C FRANK IONS Common Stock M - Exercise D 39.8700 15,000 598 47,364
2020-06-29 2020-06-25 4 Castleman Breaux IONS Common Stock S - Sale D 60.0000 -10,000 -600 15,183
2020-06-29 2020-06-25 4 Castleman Breaux IONS Common Stock M - Exercise D 26.6600 10,000 267 25,183
2020-06-26 2020-06-25 4 CROOKE STANLEY T IONS Common Stock S - Sale D 60.1076 -9,914 -596 2,021
2020-06-26 2020-06-24 4 CROOKE STANLEY T IONS Common Stock S - Sale D 58.8000 -5,000 -294 11,935
2020-06-25 2020-06-23 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) M - Exercise D 9.22 -15,000 0
2020-06-25 2020-06-23 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 58.7600 -15,000 -881 96,983
2020-06-25 2020-06-23 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 9.2200 15,000 138 111,983
2020-06-19 2020-06-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 58.3250 -10,000 -583 16,935
2020-06-19 2020-06-17 4 CROOKE STANLEY T By Wife IONS Common Stock S - Sale I 58.2500 -2,000 -116 3,581
2020-06-19 2020-06-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 57.9014 -15,000 -869 26,935
2020-06-17 2020-06-10 4 HERMAN JOAN E IONS Restricted Stock Unit M - Exercise D -3,556 10,665
2020-06-17 2020-06-10 4 HERMAN JOAN E IONS Common Stock M - Exercise D 3,556 3,556
2020-04-17 2020-04-15 4/A Cadoret-Manier Onaiza IONS Restricted Stock Unit A - Award D 22,667 22,667
2020-03-27 2020-03-17 4/A CROOKE STANLEY T IONS Common Stock S - Sale D 45.0000 -4,349 -196 71,935
2020-03-27 2020-03-17 4/A CROOKE STANLEY T IONS Common Stock S - Sale D 45.0000 -5,651 -254 76,284
2020-03-27 2020-03-17 4/A CROOKE STANLEY T IONS Common Stock S - Sale D 44.5000 -5,421 -241 81,935
2020-03-27 2020-03-17 4/A CROOKE STANLEY T IONS Common Stock S - Sale D 44.5000 -4,579 -204 87,356
2020-03-27 2020-03-25 4 CROOKE STANLEY T By Wife IONS Common Stock S - Sale I 47.0000 -1,000 -47 5,581
2020-03-27 2020-03-25 4 CROOKE STANLEY T IONS Common Stock S - Sale D 47.0000 -15,000 -705 41,935
2020-03-23 2020-03-19 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 45.0000 -1,000 -45 6,581
2020-03-23 2020-03-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 46.0000 -5,000 -230 56,545
2020-03-23 2020-03-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 44.7546 -10,000 -448 61,545
2020-03-19 2020-03-17 4 CROOKE STANLEY T IONS COMMON STOCK S - Sale D 45.0000 -4,349 -196 71,545
2020-03-19 2020-03-17 4 CROOKE STANLEY T IONS COMMON STOCK S - Sale D 45.0000 -5,651 -254 75,894
2020-03-19 2020-03-17 4 CROOKE STANLEY T IONS COMMON STOCK S - Sale D 44.5000 -5,421 -241 81,545
2020-03-19 2020-03-17 4 CROOKE STANLEY T IONS COMMON STOCK S - Sale D 44.5000 -4,969 -221 86,966
2020-03-03 2020-02-29 4 Swayze Eric IONS Common Stock J - Other D 43.1630 378 16 5,301
2020-03-03 2020-02-29 4 Geary Richard S IONS Common Stock J - Other D 43.1630 378 16 30,446
2020-03-03 2020-02-29 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 43.1630 147 6 32,374
2020-03-03 2020-02-29 4 Monia Brett P IONS Common Stock J - Other D 43.1630 314 14 28,957
2020-03-03 2020-02-29 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 43.1630 289 12 21,009
2020-03-03 2020-02-29 4 BENNETT C FRANK IONS Common Stock J - Other D 43.1630 169 7 32,364
2020-02-11 2020-02-10 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 59.6000 -3,882 -231 20,720
2020-01-31 2020-01-02 4/A Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 60.89 148,454 148,454
2020-01-17 2020-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -19,921 46,087
2020-01-17 2020-01-15 4 Monia Brett P IONS Performance Restricted Stock Units A - Award D 17,009 17,009
2020-01-17 2020-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 65,979 65,979
2020-01-17 2020-01-15 4 Monia Brett P IONS Common Stock F - Taxes D 62.0600 -7,563 -469 28,643
2020-01-17 2020-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 19,921 36,206
2020-01-17 2020-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -12,045 24,552
2020-01-17 2020-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units A - Award D 24,205 24,205
2020-01-17 2020-01-15 4 O'NEIL PATRICK R. IONS Common Stock F - Taxes D 62.0600 -4,277 -265 24,602
2020-01-17 2020-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 12,045 28,879
2020-01-17 2020-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -15,136 16,409
2020-01-17 2020-01-15 4 PARSHALL B LYNNE IONS Common Stock F - Taxes D 62.0600 -3,905 -242 64,797
2020-01-17 2020-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 15,136 68,702
2020-01-17 2020-01-15 4 Swayze Eric IONS Restricted Stock Units M - Exercise D -6,522 13,653
2020-01-17 2020-01-15 4 Swayze Eric IONS Restricted Stock Units A - Award D 12,235 12,235
2020-01-17 2020-01-15 4 Swayze Eric IONS Common Stock F - Taxes D 62.0600 -2,367 -147 4,923
2020-01-17 2020-01-15 4 Swayze Eric IONS Common Stock M - Exercise D 6,522 7,290
2020-01-17 2020-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -3,317 6,627
2020-01-17 2020-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -39,643 72,160
2020-01-17 2020-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units A - Award I 5,545 5,545
2020-01-17 2020-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units A - Award D 62,982 62,982
2020-01-17 2020-01-15 4 CROOKE STANLEY T By wife IONS Common Stock F - Taxes I 62.0600 -1,268 -79 7,581
2020-01-17 2020-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 3,317 8,849
2020-01-17 2020-01-15 4 CROOKE STANLEY T IONS Common Stock F - Taxes D 62.0600 -17,342 -1,076 91,935
2020-01-17 2020-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39,643 109,277
2020-01-17 2020-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -13,139 27,639
2020-01-17 2020-01-15 4 Geary Richard S IONS Retricted Stock Units A - Award D 24,205 24,205
2020-01-17 2020-01-15 4 Geary Richard S IONS Common Stock F - Taxes D 62.0600 -4,654 -289 30,068
2020-01-17 2020-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 13,139 34,722
2020-01-17 2020-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -12,044 24,550
2020-01-17 2020-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units A - Award D 26,800 26,800
2020-01-17 2020-01-15 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 62.0600 -4,277 -265 32,227
2020-01-17 2020-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 12,044 36,504
2020-01-17 2020-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -11,711 23,549
2020-01-17 2020-01-15 4 BENNETT C FRANK IONS Restricted Stock Units A - Award D 21,612 21,612
2020-01-17 2020-01-15 4 BENNETT C FRANK IONS Common Stock F - Taxes D 62.0600 -4,162 -258 32,195
2020-01-17 2020-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 11,711 36,357
2020-01-17 2020-01-15 4 Cadoret-Manier Onaiza IONS Restricted Stock Units A - Award D 22,667 22,667
2020-01-13 3 Cadoret-Manier Onaiza IONS No Securities Owned D 0
2020-01-13 2020-01-09 4 Cadoret-Manier Onaiza IONS Employee Stock Option (right to buy) A - Award D 63.27 51,000 51,000
2020-01-03 2019-12-06 5 CROOKE STANLEY T By trust IONS Common Stock G - Gift I -25,000 700,391
2020-01-03 2020-01-02 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) A - Award D 60.89 60,299 60,299
2020-01-03 2020-01-02 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 60.89 158,659 158,659
2020-01-03 2020-01-02 4 Monia Brett P IONS Common Stock S - Sale D 60.2500 -173 -10 16,285
2020-01-03 2020-01-02 4 O'NEIL PATRICK R. IONS Employee Stock Option (Right to Buy) A - Award D 60.89 54,461 54,461
2020-01-03 2020-01-02 4 Swayze Eric IONS Employee Stock Option (Right to Buy) A - Award D 60.89 27,528 27,528
2020-01-03 3 Swayze Eric IONS Common Stock D 1,536
2020-01-03 3 Swayze Eric IONS Common Stock D 1,536
2020-01-03 3 Swayze Eric IONS Common Stock D 1,536
2020-01-03 2020-01-02 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) A - Award D 60.89 48,626 48,626
2020-01-03 2020-01-02 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) A - Award I 60.89 12,477 12,477
2020-01-03 2020-01-02 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) A - Award D 60.89 141,709 141,709
2020-01-03 2020-01-02 4 Geary Richard S IONS Employee Stock Option (right to buy) A - Award D 60.89 54,461 54,461
2019-12-23 2019-12-23 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 -1,000 0
2019-12-23 2019-12-23 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 61.8742 -1,000 -62 12,683
2019-12-23 2019-12-23 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,000 36 13,683
2019-12-20 2019-12-20 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -3,438 0
2019-12-20 2019-12-20 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -7,196 0
2019-12-20 2019-12-20 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 61.5200 -2,014 -124 24,460
2019-12-20 2019-12-20 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.8200 3,438 37 26,474
2019-12-20 2019-12-20 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 61.5200 -4,215 -259 23,036
2019-12-20 2019-12-20 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.8200 7,196 78 27,251
2019-12-18 2019-12-16 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 -1,000 1,000
2019-12-18 2019-12-16 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 65.4465 -1,000 -65 12,683
2019-12-18 2019-12-16 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,000 36 13,683
2019-12-10 2019-12-09 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 -1,000 2,000
2019-12-10 2019-12-09 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 63.7447 -1,000 -64 12,683
2019-12-10 2019-12-09 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,000 36 13,683
2019-12-05 2019-12-04 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -10,000 0
2019-12-05 2019-12-04 4 Geary Richard S IONS Common Stock S - Sale D 65.0000 -10,000 -650 21,583
2019-12-05 2019-12-04 4 Geary Richard S IONS Common Stock M - Exercise D 14.6900 10,000 147 31,583
2019-12-05 2019-12-04 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -4,062 3,438
2019-12-05 2019-12-04 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -504 7,196
2019-12-05 2019-12-04 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 65.0000 -4,062 -264 20,055
2019-12-05 2019-12-04 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.8200 4,062 44 24,117
2019-12-05 2019-12-04 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 65.0000 -504 -33 20,055
2019-12-05 2019-12-04 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.8200 504 5 20,559
2019-12-04 2019-12-02 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 -1,000 3,000
2019-12-04 2019-12-02 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 64.0830 -1,000 -64 12,683
2019-12-04 2019-12-02 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,000 36 13,683
2019-12-04 2019-12-02 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -5,000 10,000
2019-12-04 2019-12-02 4 Geary Richard S IONS Common Stock S - Sale D 65.0574 -5,000 -325 21,583
2019-12-04 2019-12-02 4 Geary Richard S IONS Common Stock M - Exercise D 14.6900 5,000 73 26,583
2019-11-26 2019-11-25 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -4,000 7,700
2019-11-26 2019-11-25 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 62.5000 -4,000 -250 20,055
2019-11-26 2019-11-25 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.8200 4,000 43 24,055
2019-11-26 2019-11-25 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 62.9000 -812 -51 12,683
2019-11-21 2019-11-19 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -4,000 11,700
2019-11-21 2019-11-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 58.8000 -4,000 -235 20,055
2019-11-21 2019-11-19 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.8200 4,000 43 24,055
2019-11-21 2019-11-20 4 Monia Brett P IONS Common Stock S - Sale D 60.0100 -5,776 -347 16,458
2019-11-21 2019-11-20 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 60.0000 -2,000 -120 13,495
2019-10-17 2019-10-15 4 Reikes Peter N IONS Restricted Stock Units M - Exercise D -1,778 5,332
2019-10-17 2019-10-15 4 Reikes Peter N IONS Common Stock M - Exercise D 1,778 1,778
2019-10-17 2019-10-15 4 Hayden Michael R IONS Restricted Stock Units M - Exercise D -1,778 5,332
2019-10-17 2019-10-15 4 Hayden Michael R IONS Common Stock M - Exercise D 1,778 1,778
2019-08-22 2019-08-21 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -10,000 27,180
2019-08-22 2019-08-21 4 CROOKE STANLEY T IONS Common Stock S - Sale D 72.1500 -10,000 -722 69,634
2019-08-22 2019-08-21 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 10,000 399 79,634
2019-08-22 2019-08-20 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 39.87 -2,000 500
2019-08-22 2019-08-20 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -10,000 37,180
2019-08-22 2019-08-20 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 71.0000 -2,000 -142 5,532
2019-08-22 2019-08-20 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 39.8700 2,000 80 7,532
2019-08-22 2019-08-20 4 CROOKE STANLEY T IONS Common Stock S - Sale D 71.0000 -10,000 -710 69,634
2019-08-22 2019-08-20 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 10,000 399 79,634
2019-07-22 2019-07-18 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -10,000 47,180
2019-07-22 2019-07-18 4 CROOKE STANLEY T IONS Common Stock S - Sale D 70.2506 -10,000 -703 69,634
2019-07-22 2019-07-18 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 10,000 399 79,634
2019-07-17 2019-07-15 4 McDevitt Damien IONS Restricted Stock Units M - Exercise D -3,542 10,625
2019-07-17 2019-07-15 4 McDevitt Damien IONS Common Stock F - Taxes D 67.8600 -1,225 -83 2,573
2019-07-17 2019-07-15 4 McDevitt Damien IONS Common Stock M - Exercise D 3,542 3,798
2019-07-03 2019-07-03 4/A BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -667 1,333
2019-07-03 2019-07-03 4/A BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 667 96,983
2019-07-03 2019-07-02 4/A BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4/A BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 889 96,316
2019-07-03 2019-07-01 4/A BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4/A BERTHELSEN SPENCER R IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4/A BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -667 666
2019-07-03 2019-07-01 4/A BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -666 0
2019-07-03 2019-07-01 4/A BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 667 95,427
2019-07-03 2019-07-01 4/A BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 666 94,760
2019-07-03 2019-07-03 4/A Castleman Breaux IONS Restricted Stock Units M - Exercise D -667 1,333
2019-07-03 2019-07-03 4/A Castleman Breaux IONS Common Stock M - Exercise D 667 15,183
2019-07-03 2019-07-02 4/A Castleman Breaux IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4/A Castleman Breaux IONS Common Stock M - Exercise D 889 14,516
2019-07-03 2019-07-01 4/A Castleman Breaux IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4/A Castleman Breaux IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4/A Castleman Breaux IONS Restricted Stock Units M - Exercise D -667 666
2019-07-03 2019-07-01 4/A Castleman Breaux IONS Restricted Stock Units M - Exercise D -666 0
2019-07-03 2019-07-01 4/A Castleman Breaux IONS Common Stock M - Exercise D 667 13,627
2019-07-03 2019-07-01 4/A Castleman Breaux IONS Common Stock M - Exercise D 666 12,960
2019-07-03 2019-07-01 4 Hayden Michael R IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 Hayden Michael R IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-03 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -667 1,333
2019-07-03 2019-07-03 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 667 12,683
2019-07-03 2019-07-02 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 889 12,016
2019-07-03 2019-07-01 4 MUTO FREDERICK T IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -667 666
2019-07-03 2019-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -666 0
2019-07-03 2019-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 667 11,127
2019-07-03 2019-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 666 10,460
2019-07-03 2019-07-03 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -667 1,333
2019-07-03 2019-07-03 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 667 15,495
2019-07-03 2019-07-02 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 889 14,828
2019-07-03 2019-07-01 4 KLEIN JOSEPH III IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -667 666
2019-07-03 2019-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -666 0
2019-07-03 2019-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 667 13,939
2019-07-03 2019-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 666 13,272
2019-07-03 2019-07-02 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 889 53,566
2019-07-03 2019-07-01 4 PARSHALL B LYNNE IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 PARSHALL B LYNNE IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4 Reikes Peter N IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 Reikes Peter N IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4 HERMAN JOAN E IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 HERMAN JOAN E IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-03 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -667 1,333
2019-07-03 2019-07-03 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 667 61,805
2019-07-03 2019-07-02 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 889 61,138
2019-07-03 2019-07-01 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -667 666
2019-07-03 2019-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -666 0
2019-07-03 2019-07-01 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 667 60,249
2019-07-03 2019-07-01 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock M - Exercise I 666 59,582
2019-07-03 2019-07-03 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -667 1,333
2019-07-03 2019-07-03 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 667 13,308
2019-07-03 2019-07-02 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -889 2,666
2019-07-03 2019-07-02 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 889 12,641
2019-07-03 2019-07-01 4 LOSCALZO JOSEPH IONS Director Stock Option (right to buy) A - Award D 64.80 16,000 16,000
2019-07-03 2019-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units A - Award D 7,110 7,110
2019-07-03 2019-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -667 666
2019-07-03 2019-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -666 0
2019-07-03 2019-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 667 11,752
2019-07-03 2019-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 666 11,085
2019-07-02 2019-07-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 45.7045 105 5 20,055
2019-07-02 2019-07-02 4 Monia Brett P IONS Common Stock S - Sale D 66.4000 -210 -14 22,234
2019-07-02 2019-07-01 4 Monia Brett P IONS Common Stock J - Other D 45.7045 173 8 22,444
2019-07-02 2019-07-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 45.7045 161 7 16,834
2019-07-02 2019-07-01 4 McDevitt Damien IONS Common Stock J - Other D 45.7045 256 12 256
2019-07-02 2019-07-01 4 BENNETT C FRANK IONS Common Stock J - Other D 45.7045 118 5 24,646
2019-07-02 2019-07-01 4 Geary Richard S IONS Common Stock J - Other D 45.7045 141 6 21,583
2019-06-26 2019-06-24 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) M - Exercise D 16.32 -15,000 0
2019-06-26 2019-06-24 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 63.8430 -9,690 -619 94,094
2019-06-26 2019-06-24 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 16.3200 9,690 158 103,784
2019-06-26 2019-06-24 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 63.3661 -5,310 -336 94,094
2019-06-26 2019-06-24 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 16.3200 5,310 87 99,404
2019-06-12 2019-06-10 4 HERMAN JOAN E IONS Restricted Stock Units A - Award D 14,221 14,221
2019-06-12 2019-06-10 4 HERMAN JOAN E IONS Director Stock Option (right to buy) A - Award D 63.90 32,000 32,000
2019-06-12 3 HERMAN JOAN E IONS No Securities Owned D 0
2019-06-06 2019-06-04 4 MUTO FREDERICK T IONS Stock Option (right to buy) M - Exercise D 16.32 15,000 0
2019-06-06 2019-06-04 4 MUTO FREDERICK T IONS Common Stock S - Sale D 65.2900 -15,000 -979 9,794
2019-06-06 2019-06-04 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 16.3200 15,000 245 24,794
2019-05-08 2019-05-06 4 MUTO FREDERICK T IONS Stock Option (right to buy) M - Exercise D 24.42 8,000 0
2019-05-08 2019-05-06 4 MUTO FREDERICK T IONS Common Stock S - Sale D 72.7502 -8,000 -582 9,794
2019-05-08 2019-05-06 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 24.4200 8,000 195 17,794
2019-05-01 2019-04-29 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 39.87 50,000 7,500
2019-05-01 2019-04-29 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 75.0127 -50,000 -3,751 52,677
2019-05-01 2019-04-29 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 50,000 1,993 102,677
2019-04-17 2019-04-16 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 39.87 -700 2,500
2019-04-17 2019-04-16 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -300 0
2019-04-17 2019-04-16 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -13,320 57,180
2019-04-17 2019-04-16 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -6,680 0
2019-04-17 2019-04-16 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 84.7500 -700 -59 5,532
2019-04-17 2019-04-16 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 39.8700 700 28 6,232
2019-04-17 2019-04-16 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 84.7500 -300 -25 5,532
2019-04-17 2019-04-16 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 300 3 5,832
2019-04-17 2019-04-16 4 CROOKE STANLEY T IONS Common Stock S - Sale D 84.5623 -13,320 -1,126 69,634
2019-04-17 2019-04-16 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 13,320 531 82,954
2019-04-17 2019-04-16 4 CROOKE STANLEY T IONS Common Stock S - Sale D 84.7500 -6,680 -566 69,634
2019-04-17 2019-04-16 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 6,680 98 76,314
2019-04-17 2019-04-15 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -1,000 300
2019-04-17 2019-04-15 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -10,000 6,680
2019-04-17 2019-04-15 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 85.2500 -1,000 -85 5,532
2019-04-17 2019-04-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 1,000 11 6,532
2019-04-17 2019-04-15 4 CROOKE STANLEY T IONS Common Stock S - Sale D 85.2500 -10,000 -852 69,634
2019-04-17 2019-04-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 10,000 147 79,634
2019-04-10 2019-04-08 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 39.87 20,000 25,000
2019-04-10 2019-04-08 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 14.69 2,240 15,000
2019-04-10 2019-04-08 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 47.34 24,000 1,439
2019-04-10 2019-04-08 4 Geary Richard S IONS Common Stock S - Sale D 84.0000 -20,000 -1,680 21,442
2019-04-10 2019-04-08 4 Geary Richard S IONS Common Stock M - Exercise D 39.8700 20,000 797 41,442
2019-04-10 2019-04-08 4 Geary Richard S IONS Common Stock S - Sale D 84.0000 -2,240 -188 21,442
2019-04-10 2019-04-08 4 Geary Richard S IONS Common Stock M - Exercise D 14.6900 2,240 33 23,682
2019-04-10 2019-04-08 4 Geary Richard S IONS Common Stock S - Sale D 84.0247 -24,000 -2,017 21,442
2019-04-10 2019-04-08 4 Geary Richard S IONS Common Stock M - Exercise D 47.3400 24,000 1,136 45,442
2019-04-05 2019-04-05 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 61.68 2,252 7,969
2019-04-05 2019-04-05 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 84.7500 -2,252 -191 16,673
2019-04-05 2019-04-05 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 61.6800 2,252 139 18,925
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 49.25 8,000 46,638
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 47.34 5,600 20,825
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 61.57 2,657 0
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 61.68 20,365 10,221
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 84.2500 -1,878 -158 16,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 82.0100 -1,122 -92 18,551
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 84.2900 -8,000 -674 19,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 49.2500 8,000 394 27,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 82.1000 -3,600 -296 19,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 47.3400 3,600 170 23,273
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 84.2000 -2,000 -168 19,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 47.3400 2,000 95 21,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 82.0300 -2,657 -218 19,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 61.5700 2,657 164 22,330
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 82.1900 -4,873 -401 19,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 61.6800 4,873 301 24,546
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 84.7500 -15,492 -1,313 19,673
2019-04-05 2019-04-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 61.6800 15,492 956 35,165
2019-04-05 2019-04-03 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 61.68 7,654 30,586
2019-04-05 2019-04-03 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 84.8300 -7,654 -649 19,673
2019-04-05 2019-04-03 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 61.6800 7,654 472 27,327
2019-03-20 2019-03-18 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 61.57 28,800 2,657
2019-03-20 2019-03-18 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 78.7912 -28,800 -2,269 19,673
2019-03-20 2019-03-18 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 61.5700 28,800 1,773 48,473
2019-03-20 2019-03-19 4 WENDER JOSEPH H By Joseph H. Wender Trust IONS Common Stock S - Sale I 79.6258 -10,000 -796 58,916
2019-03-14 2019-03-12 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 39.87 8,334 57,500
2019-03-14 2019-03-12 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 75.0000 -8,334 -625 52,677
2019-03-14 2019-03-12 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 8,334 332 61,011
2019-03-01 2019-02-27 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 39.87 8,333 65,834
2019-03-01 2019-02-27 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 70.0000 -8,333 -583 52,677
2019-03-01 2019-02-27 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 8,333 332 61,010
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 39.87 8,000 0
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 47.34 18,800 4,755
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 68.7500 -8,000 -550 19,673
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 39.8700 8,000 319 27,673
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 68.7500 -14,100 -969 19,673
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 47.3400 14,100 667 33,773
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 64.5116 -4,700 -303 19,673
2019-03-01 2019-02-27 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 47.3400 4,700 222 24,373
2019-02-27 2019-02-26 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -37,000 70,500
2019-02-27 2019-02-26 4 CROOKE STANLEY T IONS Common Stock S - Sale D 61.5351 -37,000 -2,277 69,634
2019-02-27 2019-02-26 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 37,000 1,475 106,634
2019-02-27 2019-02-25 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -40,000 107,500
2019-02-27 2019-02-25 4 CROOKE STANLEY T IONS Common Stock S - Sale D 60.0675 -40,000 -2,403 69,634
2019-02-27 2019-02-25 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 40,000 1,595 109,634
2019-02-14 2019-02-13 4 Geary Richard S IONS Common Stock S - Sale D 60.0000 -999 -60 21,442
2019-02-14 2019-02-13 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 39.87 -5,300 3,200
2019-02-14 2019-02-13 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -1,604 1,300
2019-02-14 2019-02-13 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -40,000 147,500
2019-02-14 2019-02-13 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 60.0000 -5,300 -318 5,532
2019-02-14 2019-02-13 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 39.8700 5,300 211 10,832
2019-02-14 2019-02-13 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 60.0000 -1,604 -96 5,532
2019-02-14 2019-02-13 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 1,604 17 7,136
2019-02-14 2019-02-13 4 CROOKE STANLEY T IONS Common Stock S - Sale D 60.1007 -40,000 -2,404 69,634
2019-02-14 2019-02-13 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 39.8700 40,000 1,595 109,634
2019-02-14 2019-02-12 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 39.87 275 8,000
2019-02-14 2019-02-12 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 59.5000 -275 -16 19,673
2019-02-14 2019-02-12 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 39.8700 275 11 19,948
2019-02-05 2019-02-01 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 14.69 9,013 0
2019-02-05 2019-02-01 4 BENNETT C FRANK IONS Common Stock S - Sale D 58.2900 -9,013 -525 24,528
2019-02-05 2019-02-01 4 BENNETT C FRANK IONS Common Stock M - Exercise D 14.6900 9,013 132 33,541
2019-02-05 2019-02-05 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 39.87 15,600 8,275
2019-02-05 2019-02-05 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 59.5000 -15,600 -928 19,673
2019-02-05 2019-02-05 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 39.8700 15,600 622 35,273
2019-02-05 2019-02-01 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 39.87 4,000 23,875
2019-02-05 2019-02-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 58.2900 -4,000 -233 19,673
2019-02-05 2019-02-01 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 39.8700 4,000 159 23,673
2019-01-17 2019-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -10,006 20,280
2019-01-17 2019-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 45,728 45,728
2019-01-17 2019-01-15 4 Monia Brett P IONS Common Stock F - Taxes D 58.2600 -3,572 -208 22,275
2019-01-17 2019-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 10,006 25,847
2019-01-17 2019-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -7,891 14,463
2019-01-17 2019-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units A - Award D 22,131 22,131
2019-01-17 2019-01-15 4 HOUGEN ELIZABETH L IONS Common Stock F - Taxes D 58.2600 -2,842 -166 19,823
2019-01-17 2019-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 7,891 22,665
2019-01-17 2019-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -8,085 15,048
2019-01-17 2019-01-15 4 Geary Richard S IONS Restricted Stock Units A - Award D 25,730 25,730
2019-01-17 2019-01-15 4 Geary Richard S IONS Common Stock F - Taxes D 58.2600 -2,908 -169 22,034
2019-01-17 2019-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 8,085 24,942
2019-01-17 2019-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -7,822 14,463
2019-01-17 2019-01-15 4 BENNETT C FRANK IONS Restricted Stock Units A - Award D 20,797 20,797
2019-01-17 2019-01-15 4 BENNETT C FRANK IONS Common Stock F - Taxes D 58.2600 -2,818 -164 24,400
2019-01-17 2019-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 7,822 27,218
2019-01-17 2019-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -20,656 35,100
2019-01-17 2019-01-15 4 PARSHALL B LYNNE IONS Common Stock F - Taxes D 58.2600 -6,159 -359 52,677
2019-01-17 2019-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 20,656 58,836
2019-01-17 2019-01-15 4 McDevitt Damien IONS Restricted Stock Units A - Award D 13,065 13,065
2019-01-17 2019-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -7,823 14,466
2019-01-17 2019-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units A - Award D 22,131 22,131
2019-01-17 2019-01-15 4 O'NEIL PATRICK R. IONS Common Stock F - Taxes D 58.2600 -2,734 -159 19,607
2019-01-17 2019-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 7,823 22,341
2019-01-17 2019-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -2,346 4,612
2019-01-17 2019-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -30,587 48,077
2019-01-17 2019-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units A - Award I 5,332 5,332
2019-01-17 2019-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units A - Award D 63,726 63,726
2019-01-17 2019-01-15 4 CROOKE STANLEY T By wife IONS Common Stock F - Taxes I 58.2600 -942 -55 5,532
2019-01-17 2019-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 2,346 6,474
2019-01-17 2019-01-15 4 CROOKE STANLEY T IONS Common Stock F - Taxes D 58.2600 -12,686 -739 69,634
2019-01-17 2019-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 30,587 82,320
2019-01-03 2019-01-03 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -4,000 27,875
2019-01-03 2019-01-03 4 O'NEIL PATRICK R. IONS Empoyee Stock Option (right to buy) M - Exercise D 10.82 -400 0
2019-01-03 2019-01-03 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 54.8000 -4,000 -219 14,584
2019-01-03 2019-01-03 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 39.8700 4,000 159 18,584
2019-01-03 2019-01-03 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 54.8000 -400 -22 14,584
2019-01-03 2019-01-03 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 400 4 14,984
2019-01-03 2019-01-02 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) A - Award D 53.77 49,800 49,800
2019-01-03 2019-01-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 36.4480 66 2 14,584
2019-01-03 2019-01-02 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 53.77 102,900 102,900
2019-01-03 2019-01-02 4 Monia Brett P IONS Common Stock S - Sale D 53.5000 -214 -11 15,837
2019-01-03 2019-01-01 4 Monia Brett P IONS Common Stock J - Other D 36.4480 210 8 16,051
2019-01-03 2019-01-02 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) A - Award D 53.77 49,800 49,800
2019-01-03 2019-01-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 36.4480 127 5 14,901
2019-01-03 2019-01-02 4 McDevitt Damien IONS Employee Stock Option (right to buy) A - Award D 53.77 29,400 29,400
2019-01-03 2019-01-02 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) A - Award I 53.77 12,000 12,000
2019-01-03 2019-01-02 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) A - Award D 53.77 143,400 143,400
2019-01-03 2019-01-02 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) A - Award D 53.77 46,800 46,800
2019-01-03 2019-01-01 4 BENNETT C FRANK IONS Common Stock J - Other D 36.4480 128 5 19,524
2019-01-03 2019-01-02 4 Geary Richard S IONS Employee Stock Option (right to buy) A - Award D 53.77 57,900 57,900
2019-01-03 2019-01-01 4 Geary Richard S IONS Common Stock J - Other D 36.4480 407 15 17,264
2018-12-20 2018-12-19 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 7.25 2,063 0
2018-12-20 2018-12-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 52.0500 -2,063 -107 14,774
2018-12-20 2018-12-19 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 7.2500 2,063 15 16,837
2018-12-20 2018-12-18 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 7.25 2,000 2,063
2018-12-20 2018-12-18 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 52.0000 -2,000 -104 14,774
2018-12-20 2018-12-18 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 7.2500 2,000 14 16,774
2018-11-26 2018-11-23 4 Monia Brett P IONIS Employee Stock Option (right to buy) M - Exercise D 14.69 34,000 0
2018-11-26 2018-11-23 4 Monia Brett P IONIS Common Stock S - Sale D 55.0017 -34,000 -1,870 15,841
2018-11-26 2018-11-23 4 Monia Brett P IONIS Common Stock M - Exercise D 14.6900 34,000 499 49,841
2018-11-01 2018-11-01 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 14.69 12,500 9,013
2018-11-01 2018-11-01 4 BENNETT C FRANK IONS Common Stock S - Sale D 49.5396 -12,500 -619 19,396
2018-11-01 2018-11-01 4 BENNETT C FRANK IONS Common Stock M - Exercise D 14.6900 12,500 184 31,896
2018-10-15 2018-10-15 4 Reikes Peter N IONS Restricted Stock Units A - Award D 7,110 7,110
2018-10-15 2018-10-15 4 Hayden Michael R IONS Restricted Stock Units A - Award D 7,110 7,110
2018-09-25 3 Hayden Michael R IONS Common Stock D 0
2018-09-24 2018-09-20 4 Hayden Michael R IONS Director Stock Option (right to buy) A - Award D 50.80 32,000 32,000
2018-09-24 2018-09-23 4 Reikes Peter N IONS Director Stock Option (right to buy) A - Award D 49.14 32,000 32,000
2018-09-24 3 Reikes Peter N IONS No Securities Owned D 0
2018-08-29 2018-08-27 4 Monia Brett P IONS Employee Stock Option (right to buy) M - Exercise D 7.21 7,500 0
2018-08-29 2018-08-27 4 Monia Brett P IONS Employee Stock Option (right to buy) M - Exercise D 7.25 8,993 0
2018-08-29 2018-08-27 4 Monia Brett P IONS Common Stock S - Sale D 54.0000 -7,500 -405 15,841
2018-08-29 2018-08-27 4 Monia Brett P IONS Common Stock M - Exercise D 7.2100 7,500 54 23,341
2018-08-29 2018-08-27 4 Monia Brett P IONS Common Stock S - Sale D 54.0000 -8,993 -486 15,841
2018-08-29 2018-08-27 4 Monia Brett P IONS Common Stock M - Exercise D 7.2500 8,993 65 24,834
2018-08-09 2018-08-08 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 14.69 12,487 21,513
2018-08-09 2018-08-08 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 7.25 13 0
2018-08-09 2018-08-08 4 BENNETT C FRANK IONS Common Stock S - Sale D 45.0000 -12,487 -562 19,396
2018-08-09 2018-08-08 4 BENNETT C FRANK IONS Common Stock M - Exercise D 14.6900 12,487 183 31,883
2018-08-09 2018-08-08 4 BENNETT C FRANK IONS Common Stock S - Sale D 45.0000 -13 -1 19,396
2018-08-09 2018-08-08 4 BENNETT C FRANK IONS Common Stock M - Exercise D 7.2500 13 0 19,409
2018-07-25 2018-07-24 4 Monia Brett P IONS Common Stock S - Sale D 47.0300 -156 -7 15,841
2018-07-19 2018-07-17 4 WENDER JOSEPH H IONS Non-Employee Director Stock Option (right to buy) M - Exercise D 9.22 -15,000 0
2018-07-19 2018-07-17 4 WENDER JOSEPH H IONS Non-Employee Director Stock Option (right to buy) M - Exercise D 9.30 -15,000 0
2018-07-19 2018-07-17 4 WENDER JOSEPH H By Joseph H Wender Trust IONS Common Stock M - Exercise I 9.3000 15,000 140 68,916
2018-07-19 2018-07-17 4 WENDER JOSEPH H By Joseph H Wender Trust IONS Common Stock M - Exercise I 9.2200 15,000 138 53,916
2018-07-16 2018-07-15 4 McDevitt Damien IONS Restricted Stock Units A - Award D 14,167 14,167
2018-07-03 2018-07-03 4/A MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -667 2,000
2018-07-03 2018-07-03 4/A MUTO FREDERICK T IONS Common Stock M - Exercise D 667 9,794
2018-07-03 2018-07-02 4/A MUTO FREDERICK T IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4/A MUTO FREDERICK T IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-01 4/A MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -2,000 1,999
2018-07-03 2018-07-01 4/A MUTO FREDERICK T IONS Common Stock M - Exercise D 2,000 9,127
2018-07-03 2018-07-01 4 Monia Brett P IONS Common Stock J - Other D 35.4195 214 8 15,997
2018-07-03 2018-07-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 35.4195 274 10 14,774
2018-07-03 2018-07-01 4 Geary Richard S IONS Common Stock J - Other D 35.4195 177 6 16,857
2018-07-03 2018-07-01 4 BENNETT C FRANK IONS Common Stock J - Other D 35.4195 282 10 19,396
2018-07-03 2018-07-02 4 PARSHALL B LYNNE IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4 PARSHALL B LYNNE IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-03 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -667 2,000
2018-07-03 2018-07-03 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 667 10,419
2018-07-03 2018-07-02 4 LOSCALZO JOSEPH IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4 LOSCALZO JOSEPH IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -2,000 1,999
2018-07-03 2018-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 2,000 9,752
2018-07-03 2018-07-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 35.4195 66 2 14,518
2018-07-03 2018-07-03 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -667 2,000
2018-07-03 2018-07-03 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 667 12,606
2018-07-03 2018-07-02 4 KLEIN JOSEPH III IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4 KLEIN JOSEPH III IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -2,000 1,999
2018-07-03 2018-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 2,000 11,939
2018-07-03 2018-07-03 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -667 2,000
2018-07-03 2018-07-03 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 667 94,094
2018-07-03 2018-07-02 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4 BERTHELSEN SPENCER R IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -2,000 1,999
2018-07-03 2018-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 2,000 93,427
2018-07-03 2018-07-03 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -667 2,000
2018-07-03 2018-07-03 4 WENDER JOSEPH H IONS Common Stock M - Exercise D 667 38,916
2018-07-03 2018-07-02 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4 WENDER JOSEPH H IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -2,000 1,999
2018-07-03 2018-07-01 4 WENDER JOSEPH H IONS Common Stock M - Exercise D 2,000 38,249
2018-07-03 2018-07-03 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -667 2,000
2018-07-03 2018-07-03 4 Castleman Breaux IONS Common Stock M - Exercise D 667 12,294
2018-07-03 2018-07-02 4 Castleman Breaux IONS Director Stock Option (right to buy) A - Award D 42.88 16,000 16,000
2018-07-03 2018-07-02 4 Castleman Breaux IONS Restricted Stock Units A - Award D 3,555 3,555
2018-07-03 2018-07-01 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -2,000 1,999
2018-07-03 2018-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 2,000 11,627
2018-06-25 2018-06-25 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) M - Exercise D 13.88 -15,000 0
2018-06-25 2018-06-25 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 42.4700 -9,300 -395 91,427
2018-06-25 2018-06-25 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 13.8800 9,300 129 100,727
2018-06-25 2018-06-25 4 BERTHELSEN SPENCER R IONS Common Stock S - Sale D 42.0300 -5,700 -240 91,427
2018-06-25 2018-06-25 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 13.8800 5,700 79 97,127
2018-06-18 2018-06-18 4 McDevitt Damien IONS Employee Stock Option (right to buy) A - Award D 43.60 63,750 63,750
2018-06-18 3 McDevitt Damien IONS No Securities Owned D 0
2018-05-31 2018-05-31 4 MUTO FREDERICK T IONS Non-Employee Director Stock Option M - Exercise D 13.88 -15,000 0
2018-05-31 2018-05-31 4 MUTO FREDERICK T IONS Common Stock S - Sale D 46.4500 -15,000 -697 7,127
2018-05-31 2018-05-31 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 13.8800 15,000 208 22,127
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) M - Exercise D 13.88 -15,000 0
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Common Stock S - Sale D 45.0300 -8,590 -387 36,249
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Common Stock M - Exercise D 13.8800 8,590 119 44,839
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Common Stock S - Sale D 45.7900 -6,010 -275 36,249
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Common Stock M - Exercise D 13.8800 6,010 83 42,259
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Common Stock S - Sale D 44.0200 -400 -18 36,249
2018-05-11 2018-05-11 4 WENDER JOSEPH H IONS Common Stock M - Exercise D 13.8800 400 6 36,649
2018-05-11 2018-05-11 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 7.25 12,500 13
2018-05-11 2018-05-11 4 BENNETT C FRANK IONS Common Stock S - Sale D 45.0000 -12,500 -562 19,114
2018-05-11 2018-05-11 4 BENNETT C FRANK IONS Common Stock M - Exercise D 7.2500 12,500 91 31,614
2018-04-19 2018-04-17 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -4,000 2,904
2018-04-19 2018-04-17 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -9,962 16,680
2018-04-19 2018-04-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 44.5000 -2,000 -89 4,128
2018-04-19 2018-04-17 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 2,000 22 6,128
2018-04-19 2018-04-17 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 2,000 22 6,128
2018-04-19 2018-04-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 44.3000 -2,000 -89 4,128
2018-04-19 2018-04-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 44.5000 -4,981 -222 51,733
2018-04-19 2018-04-17 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 4,981 73 56,714
2018-04-19 2018-04-17 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 4,981 73 56,714
2018-04-19 2018-04-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 44.3000 -4,981 -221 51,733
2018-03-30 2018-03-29 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 24.42 2,000 0
2018-03-30 2018-03-29 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 46.1500 -2,000 -92 9,939
2018-03-30 2018-03-29 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 24.4200 2,000 49 11,939
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 24.42 2,000 2,000
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 52.1100 -200 -10 9,939
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 24.4200 200 5 10,139
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 51.5900 -900 -46 9,939
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 24.4200 900 22 10,839
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 24.4200 900 22 10,839
2018-03-16 2018-03-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 50.4500 -900 -45 9,939
2018-03-13 2018-03-12 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,000 400
2018-03-13 2018-03-12 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -1,000 -55 14,452
2018-03-13 2018-03-12 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 1,000 11 15,452
2018-03-01 2018-02-28 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 3,000 0
2018-03-01 2018-02-28 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 52.2900 -2,100 -110 9,939
2018-03-01 2018-02-28 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 2,100 75 12,039
2018-03-01 2018-02-28 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 51.0200 -900 -46 9,939
2018-03-01 2018-02-28 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 900 32 10,839
2018-02-16 2018-02-15 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 3,000 3,000
2018-02-16 2018-02-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 49.2000 -1,600 -79 9,939
2018-02-16 2018-02-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,600 57 11,539
2018-02-16 2018-02-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 48.7600 -1,400 -68 9,939
2018-02-16 2018-02-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,400 50 11,339
2018-02-05 2018-02-03 4/A LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -937 0
2018-02-05 2018-02-03 4/A LOSCALZO JOSEPH IONS Common Stock M - Exercise D 937 7,752
2018-02-01 2018-02-01 4/A BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 7.25 12,500 12,513
2018-02-01 2018-02-01 4/A BENNETT C FRANK IONS Common Stock S - Sale D 52.5008 -12,500 -656 19,114
2018-02-01 2018-02-01 4/A BENNETT C FRANK IONS Common Stock M - Exercise D 7.2500 12,500 91 31,614
2018-01-31 2018-01-29 4/A CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -1,000 6,904
2018-01-31 2018-01-29 4/A CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -10,000 26,642
2018-01-31 2018-01-29 4/A CROOKE STANLEY T By wife IONS Common Stock S - Sale I 54.1200 -1,000 -54 4,128
2018-01-31 2018-01-29 4/A CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 1,000 11 5,128
2018-01-31 2018-01-29 4/A CROOKE STANLEY T IONS Common Stock S - Sale D 54.1200 -10,000 -541 51,733
2018-01-31 2018-01-29 4/A CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 10,000 147 61,733
2018-01-31 2018-01-30 4/A KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 3,000 6,000
2018-01-31 2018-01-30 4/A KLEIN JOSEPH III IONS Common Stock S - Sale D 52.8600 -3,000 -159 9,939
2018-01-31 2018-01-30 4/A KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 3,000 107 12,939
2018-01-31 2018-01-29 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -300 1,400
2018-01-31 2018-01-29 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -55 0
2018-01-31 2018-01-29 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -300 -16 14,452
2018-01-31 2018-01-29 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 300 3 14,752
2018-01-31 2018-01-29 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -55 -3 14,452
2018-01-31 2018-01-29 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 55 1 14,507
2018-01-29 2018-01-25 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -645 55
2018-01-29 2018-01-25 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -645 -35 14,452
2018-01-29 2018-01-25 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 645 7 15,097
2018-01-17 2018-01-16 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 51.7600 -2,724 -141 14,500
2018-01-17 2018-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -6,732 10,217
2018-01-17 2018-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units A - Award D 12,137 12,137
2018-01-17 2018-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 6,732 17,224
2018-01-17 2018-01-16 4 Monia Brett P IONS Common Stock S - Sale D 51.7600 -2,821 -146 15,783
2018-01-17 2018-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -6,985 10,703
2018-01-17 2018-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 6,667 6,667
2018-01-17 2018-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 12,916 12,916
2018-01-17 2018-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 6,985 18,604
2018-01-17 2018-01-14 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 53.22 30,000 30,000
2018-01-17 2018-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -1,722 3,047
2018-01-17 2018-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -29,612 43,515
2018-01-17 2018-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units A - Award I 3,911 3,911
2018-01-17 2018-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units A - Award D 35,149 35,149
2018-01-17 2018-01-15 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 51.7600 -656 -34 4,128
2018-01-17 2018-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 1,722 4,784
2018-01-17 2018-01-15 4 CROOKE STANLEY T IONS Common Stock S - Sale D 51.7600 -15,893 -823 51,733
2018-01-17 2018-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 29,612 67,626
2018-01-17 2018-01-16 4 BENNETT C FRANK IONS Common Stock S - Sale D 51.7600 -2,696 -140 19,114
2018-01-17 2018-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -6,663 10,148
2018-01-17 2018-01-15 4 BENNETT C FRANK IONS Restricted Stock Units A - Award D 12,137 12,137
2018-01-17 2018-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 6,663 21,810
2018-01-17 2018-01-16 4 Boyce Sarah IONS Common Stock S - Sale D 51.7600 -2,196 -114 8,931
2018-01-17 2018-01-15 4 Boyce Sarah IONS Restricted Stock Units M - Exercise D -5,367 10,427
2018-01-17 2018-01-15 4 Boyce Sarah IONS Restricted Stock Units A - Award D 12,916 12,916
2018-01-17 2018-01-15 4 Boyce Sarah IONS Common Stock M - Exercise D 5,367 11,127
2018-01-17 2018-01-16 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 51.7600 -2,697 -140 14,452
2018-01-17 2018-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -6,663 10,148
2018-01-17 2018-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units A - Award D 12,141 12,141
2018-01-17 2018-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 6,663 17,149
2018-01-17 2018-01-16 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 51.7600 -5,986 -310 38,180
2018-01-17 2018-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -18,339 29,185
2018-01-17 2018-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units A - Award D 23,016 23,016
2018-01-17 2018-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 18,339 44,166
2018-01-17 2018-01-16 4 Geary Richard S IONS Common Stock S - Sale D 51.7600 -2,723 -141 16,680
2018-01-17 2018-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -6,732 10,217
2018-01-17 2018-01-15 4 Geary Richard S IONS Restricted Stock Units A - Award D 12,916 12,916
2018-01-17 2018-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 6,732 19,403
2018-01-17 2018-01-16 4 KLEIN JOSEPH III IONS Employee Stock Option (right to buy) M - Exercise D 35.53 -3,000 9,000
2018-01-17 2018-01-16 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 52.9700 -1,400 -74 9,939
2018-01-17 2018-01-16 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,400 50 11,339
2018-01-17 2018-01-16 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 52.1300 -1,600 -83 9,939
2018-01-17 2018-01-16 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 35.5300 1,600 57 11,539
2018-01-10 2018-01-08 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -1,000 7,904
2018-01-10 2018-01-08 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -10,000 36,642
2018-01-10 2018-01-08 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 52.0100 -1,000 -52 3,062
2018-01-10 2018-01-08 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 1,000 11 4,062
2018-01-10 2018-01-08 4 CROOKE STANLEY T IONS Common Stock S - Sale D 52.0100 -10,000 -520 38,014
2018-01-10 2018-01-08 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 10,000 147 48,014
2018-01-05 2018-01-03 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.82 -1,096 8,904
2018-01-05 2018-01-03 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -904 0
2018-01-05 2018-01-03 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -20,000 46,642
2018-01-05 2018-01-03 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 50.0200 -1,096 -55 3,062
2018-01-05 2018-01-03 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.8200 1,096 12 4,158
2018-01-05 2018-01-03 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 49.7100 -904 -45 3,062
2018-01-05 2018-01-03 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 904 7 3,966
2018-01-05 2018-01-03 4 CROOKE STANLEY T IONS Common Stock S - Sale D 50.0200 -20,000 -1,000 38,014
2018-01-05 2018-01-03 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 20,000 294 58,014
2018-01-02 2018-01-02 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) A - Award D 49.25 54,619 54,619
2018-01-02 2018-01-01 4 BENNETT C FRANK IONS Common Stock J - Other D 42.7550 106 5 15,147
2018-01-02 2018-01-02 4 Boyce Sarah IONS Employee Stock Option (right to buy) A - Award D 49.25 58,125 58,125
2018-01-02 2018-01-01 4 Boyce Sarah IONS Common Stock J - Other D 42.7550 491 21 5,760
2018-01-02 2018-01-02 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) A - Award I 49.25 17,603 17,603
2018-01-02 2018-01-02 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) A - Award D 49.25 158,175 158,175
2018-01-02 2018-01-02 4 Geary Richard S IONS Employee Stock Option (right to buy) A - Award D 49.25 58,125 58,125
2018-01-02 2018-01-01 4 Geary Richard S IONS Common Stock J - Other D 42.7550 320 14 12,671
2018-01-02 2018-01-02 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) A - Award D 49.25 54,619 54,619
2018-01-02 2018-01-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 42.7550 100 4 10,492
2018-01-02 2018-01-02 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 49.25 58,125 58,125
2018-01-02 2018-01-02 4 Monia Brett P IONS Common Stock S - Sale D 50.0000 -163 -8 11,619
2018-01-02 2018-01-01 4 Monia Brett P IONS Common Stock J - Other D 42.7550 156 7 11,782
2018-01-02 2018-01-02 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) A - Award D 49.25 54,638 54,638
2018-01-02 2018-01-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 42.7550 53 2 10,486
2018-01-02 2018-01-02 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) A - Award D 49.25 103,575 103,575
2018-01-02 2018-01-01 4 PARSHALL B LYNNE IONS Common Stock J - Other D 42.7550 86 4 25,827
2018-01-02 2017-12-29 4 KLEIN JOSEPH III IONS Non-Employee Director Stock Option (right to buy) M - Exercise D 28.47 -3,000 0
2018-01-02 2017-12-29 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 50.5600 -3,000 -152 9,939
2018-01-02 2017-12-29 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 28.4700 3,000 85 12,939
2017-12-19 2017-12-15 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -5,000 0
2017-12-19 2017-12-15 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 52.5500 -5,000 -263 10,392
2017-12-19 2017-12-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.2900 5,000 51 15,392
2017-12-19 2017-12-15 4 KLEIN JOSEPH III IONS NonEmployee Director stock option (right to buy) M - Exercise D 28.47 -3,000 3,000
2017-12-19 2017-12-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 51.6900 -3,000 -155 9,939
2017-12-19 2017-12-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 28.4700 3,000 85 12,939
2017-12-06 2017-12-04 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -4,000 5,000
2017-12-06 2017-12-04 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 57.0000 -4,000 -228 10,392
2017-12-06 2017-12-04 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.2900 4,000 41 14,392
2017-12-01 2017-12-01 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,000 700
2017-12-01 2017-12-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.5000 -1,000 -56 10,433
2017-12-01 2017-12-01 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 1,000 11 11,433
2017-12-01 2017-11-30 4 KLEIN JOSEPH III IONS Director Stock Option (right to buy) M - Exercise D 28.47 -3,000 6,000
2017-12-01 2017-11-30 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 53.5500 -3,000 -161 9,939
2017-12-01 2017-11-30 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 28.4700 3,000 85 12,939
2017-12-01 2017-11-29 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -6,000 9,000
2017-12-01 2017-11-29 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 53.0200 -6,000 -318 10,392
2017-12-01 2017-11-29 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.2900 6,000 62 16,392
2017-11-17 2017-11-16 4 KLEIN JOSEPH III IONS Non-Employee Director Stock Option (right to buy) M - Exercise D 12.94 -2,812 0
2017-11-17 2017-11-16 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 12.9400 2,812 36 9,939
2017-11-17 2017-11-15 4 KLEIN JOSEPH III IONS Non-Employee Director Stock Option (right to buy) M - Exercise D 28.47 -2,250 9,000
2017-11-17 2017-11-15 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 53.5600 -2,250 -121 7,127
2017-11-17 2017-11-15 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 28.4700 2,250 64 9,377
2017-11-17 2017-11-16 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -7,000 15,000
2017-11-17 2017-11-16 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 54.3500 -7,000 -380 10,392
2017-11-17 2017-11-16 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 10.2900 7,000 72 17,392
2017-11-14 2017-11-13 4 KLEIN JOSEPH III IONS Common Stock S - Sale D 55.3900 -3,000 -166 7,127
2017-11-03 2017-11-01 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,000 1,700
2017-11-03 2017-11-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 58.3500 -1,000 -58 10,433
2017-11-03 2017-11-01 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 1,000 11 11,433
2017-10-20 2017-10-18 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 39.87 -8,333 74,167
2017-10-20 2017-10-18 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -7,785 0
2017-10-20 2017-10-18 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 65.0000 -8,333 -542 25,741
2017-10-20 2017-10-18 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 39.8700 8,333 332 34,074
2017-10-20 2017-10-18 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 65.0000 -7,785 -506 25,741
2017-10-20 2017-10-18 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 14.6900 7,785 114 33,526
2017-10-20 2017-10-18 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -12,250 0
2017-10-20 2017-10-18 4 BENNETT C FRANK IONS Common Stock S - Sale D 65.0000 -12,250 -796 15,041
2017-10-20 2017-10-18 4 BENNETT C FRANK IONS Common Stock M - Exercise D 10.2900 12,250 126 27,291
2017-10-17 2017-10-13 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -7,035 0
2017-10-17 2017-10-13 4 Geary Richard S IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -426 0
2017-10-17 2017-10-13 4 Geary Richard S IONS Common Stock S - Sale D 60.0000 -7,035 -422 12,351
2017-10-17 2017-10-13 4 Geary Richard S IONS Common Stock M - Exercise D 7.2500 7,035 51 19,386
2017-10-17 2017-10-13 4 Geary Richard S IONS Common Stock S - Sale D 60.0000 -426 -26 12,351
2017-10-17 2017-10-13 4 Geary Richard S IONS Common Stock M - Exercise D 10.2900 426 4 12,777
2017-10-17 2017-10-13 4 Geary Richard S IONS Common Stock S - Sale D 60.0000 -807 -48 12,351
2017-10-17 2017-10-13 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,500 904
2017-10-17 2017-10-13 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -15,000 66,642
2017-10-17 2017-10-13 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 59.4600 -1,500 -89 3,062
2017-10-17 2017-10-13 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 1,500 11 4,562
2017-10-17 2017-10-13 4 CROOKE STANLEY T IONS Common Stock S - Sale D 59.4600 -15,000 -892 38,014
2017-10-17 2017-10-13 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 15,000 220 53,014
2017-10-06 2017-10-05 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -800 2,700
2017-10-06 2017-10-05 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -200 0
2017-10-06 2017-10-05 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -800 -44 10,433
2017-10-06 2017-10-05 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 800 9 11,233
2017-10-06 2017-10-05 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -200 -11 10,433
2017-10-06 2017-10-05 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 7.2500 200 1 10,633
2017-10-04 2017-10-04 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,000 2,404
2017-10-04 2017-10-04 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -10,000 81,642
2017-10-04 2017-10-04 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 54.2500 -500 -27 3,062
2017-10-04 2017-10-04 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-10-04 2017-10-04 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-10-04 2017-10-04 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 54.2000 -500 -27 3,062
2017-10-04 2017-10-04 4 CROOKE STANLEY T IONS Common Stock S - Sale D 54.2500 -5,000 -271 38,014
2017-10-04 2017-10-04 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 5,000 73 43,014
2017-10-04 2017-10-04 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 5,000 73 43,014
2017-10-04 2017-10-04 4 CROOKE STANLEY T IONS Common Stock S - Sale D 54.2000 -5,000 -271 38,014
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,500 3,404
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -15,000 91,642
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 52.5000 -500 -26 3,062
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 52.0500 -500 -26 3,062
2017-10-04 2017-10-02 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 51.4500 -500 -26 3,062
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Common Stock S - Sale D 52.5000 -5,000 -262 38,014
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 5,000 73 43,014
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 5,000 73 43,014
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 5,000 73 43,014
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Common Stock S - Sale D 52.0500 -5,000 -260 38,014
2017-10-04 2017-10-02 4 CROOKE STANLEY T IONS Common Stock S - Sale D 51.4500 -5,000 -257 38,014
2017-09-07 2017-09-06 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -800 200
2017-09-07 2017-09-06 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -800 -44 10,433
2017-09-07 2017-09-06 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 7.2500 800 6 11,233
2017-09-07 2017-09-05 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -200 1,000
2017-09-07 2017-09-05 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 55.0000 -200 -11 10,433
2017-09-07 2017-09-05 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 7.2500 200 1 10,633
2017-07-26 2017-07-24 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,000 12,250
2017-07-26 2017-07-24 4 BENNETT C FRANK IONS Common Stock S - Sale D 59.2900 -10,000 -593 15,041
2017-07-26 2017-07-24 4 BENNETT C FRANK IONS Common Stock M - Exercise D 10.2900 10,000 103 25,041
2017-07-24 2017-07-20 4 CROOKE STANLEY T By wife IONS Employee Stock Option M - Exercise I 7.25 -1,000 4,904
2017-07-24 2017-07-20 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -10,000 106,642
2017-07-24 2017-07-20 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 55.3500 -1,000 -55 3,062
2017-07-24 2017-07-20 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 1,000 7 4,062
2017-07-24 2017-07-20 4 CROOKE STANLEY T IONS Common Stock S - Sale D 55.3500 -10,000 -554 38,014
2017-07-24 2017-07-20 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 10,000 147 48,014
2017-07-18 2017-07-17 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,500 5,904
2017-07-18 2017-07-17 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -15,000 116,642
2017-07-18 2017-07-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 52.4500 -1,500 -79 3,062
2017-07-18 2017-07-17 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 1,500 11 4,562
2017-07-18 2017-07-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 52.4500 -15,000 -787 38,014
2017-07-18 2017-07-17 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 15,000 220 53,014
2017-07-03 2017-07-03 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,500 7,404
2017-07-03 2017-07-03 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -1,538 131,642
2017-07-03 2017-07-03 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -13,462 0
2017-07-03 2017-07-03 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 52.1000 -1,500 -78 3,062
2017-07-03 2017-07-03 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 1,500 11 4,562
2017-07-03 2017-07-03 4 CROOKE STANLEY T IONS Common Stock S - Sale D 52.3000 -1,538 -80 38,014
2017-07-03 2017-07-03 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 14.6900 1,538 23 39,552
2017-07-03 2017-07-03 4 CROOKE STANLEY T IONS Common Stock S - Sale D 52.0800 -13,462 -701 38,014
2017-07-03 2017-07-03 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 13,462 98 51,476
2017-07-03 2017-07-01 4 BENNETT C FRANK IONS Common Stock J - Other D 40.6555 253 10 15,041
2017-07-03 2017-07-01 4 Boyce Sarah IONS Common Stock J - Other D 40.6555 17 1 5,269
2017-07-03 2017-07-01 4 Geary Richard S IONS Common Stock J - Other D 40.6555 196 8 13,158
2017-07-03 2017-07-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 40.6555 104 4 10,392
2017-07-03 2017-07-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 40.6555 134 5 10,433
2017-07-03 2017-07-01 4 PARSHALL B LYNNE IONS Common Stock J - Other D 40.6555 90 4 25,741
2017-07-03 2017-07-03 4 Monia Brett P IONS Common Stock S - Sale D 51.3500 -309 -16 11,626
2017-07-03 2017-07-01 4 Monia Brett P IONS Common Stock J - Other D 40.6555 163 7 11,935
2017-07-03 2017-07-03 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) A - Award D 52.22 16,000 16,000
2017-07-03 2017-07-03 4 BERTHELSEN SPENCER R IONS Restricted Stock Units A - Award D 2,667 2,667
2017-07-03 2017-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -2,469 3,999
2017-07-03 2017-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 2,469 91,427
2017-07-03 2017-07-03 4 Castleman Breaux IONS Director Stock Option (right to buy) A - Award D 52.22 16,000 16,000
2017-07-03 2017-07-03 4 Castleman Breaux IONS Restricted Stock Units A - Award D 2,667 2,667
2017-07-03 2017-07-01 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -3,406 3,999
2017-07-03 2017-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 3,406 9,627
2017-07-03 2017-07-03 4 KLEIN JOSEPH III IONS Director Stock Option (right to buy) A - Award D 52.22 16,000 16,000
2017-07-03 2017-07-03 4 KLEIN JOSEPH III IONS Restricted Stock Units A - Award D 2,667 2,667
2017-07-03 2017-07-02 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 2,469 10,127
2017-07-03 2017-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -2,469 3,999
2017-07-03 2017-07-03 4 LOSCALZO JOSEPH IONS Director Stock Option (right to buy) A - Award D 52.22 16,000 1,600
2017-07-03 2017-07-03 4 LOSCALZO JOSEPH IONS Restricted Stock Units A - Award D 2,667 2,667
2017-07-03 2017-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -2,001 4,936
2017-07-03 2017-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 2,001 6,815
2017-07-03 2017-07-03 4 MUTO FREDERICK T IONS Director Stock Option (right to buy) A - Award D 52.22 16,000 16,000
2017-07-03 2017-07-03 4 MUTO FREDERICK T IONS Restricted Stock Units A - Award D 2,667 2,667
2017-07-03 2017-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -2,469 3,999
2017-07-03 2017-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 2,469 7,127
2017-07-03 2017-07-03 4 WENDER JOSEPH H By Joseph H Wender Trust Dtd IONS Director Stock Option (right to buy) A - Award I 52.22 16,000 16,000
2017-07-03 2017-07-03 4 WENDER JOSEPH H By Joseph H Wender Trust Dtd IONS Restricted Stock Units A - Award I 2,667 2,667
2017-07-03 2017-07-01 4 WENDER JOSEPH H By Joseph H Wender Trust Dtd IONS Restricted Stock Units M - Exercise I -2,469 3,999
2017-07-03 2017-07-01 4 WENDER JOSEPH H By Joseph W Wender Trust Dtd IONS Common Stock M - Exercise I 2,469 36,249
2017-06-02 2017-05-31 4 MUTO FREDERICK T IONS Non-Employee Director Stock Option M - Exercise D 9.77 -12,500 0
2017-06-02 2017-05-31 4 MUTO FREDERICK T IONS Common Stock S - Sale D 45.2200 -12,500 -565 4,658
2017-06-02 2017-05-31 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 9.7700 12,500 122 17,158
2017-06-02 2017-06-01 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -70 1,700
2017-06-02 2017-06-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 48.0000 -70 -3 10,299
2017-06-02 2017-06-01 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 70 1 10,369
2017-05-03 2017-05-01 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -500 1,770
2017-05-03 2017-05-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 48.7500 -500 -24 10,299
2017-05-03 2017-05-01 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 500 5 10,799
2017-05-03 2017-05-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 48.7500 -150 -7 10,299
2017-04-27 2017-04-25 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,500 8,904
2017-04-27 2017-04-25 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -15,000 13,462
2017-04-27 2017-04-25 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 47.8100 -1,500 -72 3,062
2017-04-27 2017-04-25 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 1,500 11 4,562
2017-04-27 2017-04-25 4 CROOKE STANLEY T IONS Common Stock S - Sale D 47.8100 -15,000 -717 38,014
2017-04-27 2017-04-25 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 15,000 109 53,014
2017-04-26 2017-04-24 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -426 3,500
2017-04-26 2017-04-24 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -74 2,270
2017-04-26 2017-04-24 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.0000 -426 -19 10,449
2017-04-26 2017-04-24 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 426 5 10,875
2017-04-26 2017-04-24 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.0000 -74 -3 10,449
2017-04-26 2017-04-24 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 74 1 10,523
2017-04-21 2017-04-19 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -500 10,404
2017-04-21 2017-04-19 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -5,000 28,462
2017-04-21 2017-04-19 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 43.2500 -500 -22 3,062
2017-04-21 2017-04-19 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-04-21 2017-04-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 43.2500 -5,000 -216 38,014
2017-04-21 2017-04-19 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 5,000 36 43,014
2017-04-13 2017-04-13 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -500 10,904
2017-04-13 2017-04-13 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -500 10,904
2017-04-13 2017-04-13 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -10,000 33,462
2017-04-13 2017-04-13 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 41.3000 -500 -21 3,062
2017-04-13 2017-04-13 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 41.3000 -500 -21 3,062
2017-04-13 2017-04-13 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 7.2500 500 4 3,562
2017-04-13 2017-04-13 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 500 5 3,562
2017-04-13 2017-04-13 4 CROOKE STANLEY T IONS Common Stock S - Sale D 41.3000 -10,000 -413 38,014
2017-04-13 2017-04-13 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 10,000 72 48,014
2017-04-13 2017-04-12 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,000 500
2017-04-13 2017-04-12 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -10,000 43,462
2017-04-13 2017-04-12 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 40.0700 -1,000 -40 3,062
2017-04-13 2017-04-12 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,000 10 4,062
2017-04-13 2017-04-12 4 CROOKE STANLEY T IONS Common Stock S - Sale D 40.0700 -10,000 -401 38,014
2017-04-13 2017-04-12 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 10,000 72 48,014
2017-04-13 2017-04-12 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 40.0700 -1,000 -40 10,449
2017-03-06 2017-03-03 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -5,000 22,250
2017-03-06 2017-03-03 4 BENNETT C FRANK IONS Common Stock S - Sale D 55.0000 -5,000 -275 14,788
2017-03-06 2017-03-03 4 BENNETT C FRANK IONS Common Stock M - Exercise D 10.2900 5,000 51 19,788
2017-03-06 2017-03-02 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,100 1,500
2017-03-06 2017-03-02 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -11,000 53,462
2017-03-06 2017-03-02 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 51.0500 -1,100 -56 3,062
2017-03-06 2017-03-02 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,100 11 4,162
2017-03-06 2017-03-02 4 CROOKE STANLEY T IONS Common Stock S - Sale D 51.0500 -11,000 -562 38,014
2017-03-06 2017-03-02 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 11,000 80 49,014
2017-03-02 2017-03-01 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -500 3,926
2017-03-02 2017-03-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 49.2900 -1,000 -49 11,449
2017-03-02 2017-03-01 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 49.2900 -500 -25 12,449
2017-03-02 2017-03-01 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 500 5 12,949
2017-03-02 2017-03-01 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -4,625 7,785
2017-03-02 2017-03-01 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 49.2600 -4,625 -228 25,651
2017-03-02 2017-03-01 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 14.6900 4,625 68 30,276
2017-02-27 2017-02-24 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) M - Exercise D 9.77 -12,500 0
2017-02-27 2017-02-24 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 9.7700 12,500 122 88,958
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -481 4,426
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -19 1,200
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.5000 -481 -22 12,449
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 481 5 12,930
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.5000 -19 -1 12,449
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 7.2500 19 0 12,468
2017-02-08 2017-02-06 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.0040 -1,000 -46 12,449
2017-02-03 2017-02-03 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -937 937
2017-02-03 2017-02-03 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 937 4,814
2017-01-18 2017-01-17 4 Geary Richard S IONS Common Stock S - Sale D 46.2910 -623 -29 12,962
2017-01-18 2017-01-17 4 Geary Richard S IONS Common Stock S - Sale D 46.2900 -539 -25 11,991
2017-01-18 2017-01-17 4 Geary Richard S IONS Common Stock S - Sale D 46.2910 -733 -34 11,150
2017-01-18 2017-01-17 4 Geary Richard S IONS Common Stock S - Sale D 46.2910 -546 -25 10,008
2017-01-18 2017-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,594 4,779
2017-01-18 2017-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,380 2,758
2017-01-18 2017-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,875 1,875
2017-01-18 2017-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,397 0
2017-01-18 2017-01-15 4 Geary Richard S IONS Restricted Stock Units A - Award D 7,537 7,537
2017-01-18 2017-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,594 13,585
2017-01-18 2017-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,380 12,530
2017-01-18 2017-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,875 11,883
2017-01-18 2017-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,397 10,554
2017-01-18 2017-01-17 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 46.2900 -623 -29 10,288
2017-01-18 2017-01-17 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 46.2910 -539 -25 9,317
2017-01-18 2017-01-17 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 46.2900 -733 -34 8,476
2017-01-18 2017-01-17 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 46.2900 -256 -12 7,334
2017-01-18 2017-01-17 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 46.2930 -122 -6 6,937
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -1,594 4,779
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -1,380 2,758
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -1,875 1,875
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -653 0
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -312 0
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units A - Award D 7,537 7,537
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 1,594 10,911
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 1,380 9,856
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 1,875 9,209
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 653 7,590
2017-01-18 2017-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 312 7,059
2017-01-18 2017-01-17 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 46.2893 -2,076 -96 25,651
2017-01-18 2017-01-17 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 46.2895 -2,696 -125 23,245
2017-01-18 2017-01-17 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 46.2895 -1,509 -70 20,422
2017-01-18 2017-01-17 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 46.2902 -965 -45 18,494
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -4,482 13,443
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -5,519 11,038
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -3,437 3,437
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -2,595 0
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units A - Award D 19,606 19,606
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 4,482 27,727
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 5,519 25,941
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 3,437 21,931
2017-01-18 2017-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 2,595 19,459
2017-01-18 2017-01-17 4 BENNETT C FRANK IONS Common Stock S - Sale D 46.2900 -623 -29 14,788
2017-01-18 2017-01-17 4 BENNETT C FRANK IONS Common Stock S - Sale D 46.2910 -512 -24 13,817
2017-01-18 2017-01-17 4 BENNETT C FRANK IONS Common Stock S - Sale D 46.2900 -733 -34 13,018
2017-01-18 2017-01-17 4 BENNETT C FRANK IONS Common Stock S - Sale D 46.2900 -553 -26 11,876
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,594 4,779
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,311 2,620
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,875 1,875
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,415 0
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Restricted Stock Units A - Award D 7,537 7,537
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,594 15,411
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,311 14,329
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,875 13,751
2017-01-18 2017-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,415 12,429
2017-01-18 2017-01-17 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.2900 -623 -29 13,449
2017-01-18 2017-01-17 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.2910 -512 -24 12,478
2017-01-18 2017-01-17 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.2900 -733 -34 11,679
2017-01-18 2017-01-17 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.2900 -256 -12 10,537
2017-01-18 2017-01-17 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 46.2930 -122 -6 10,140
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -1,594 4,779
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -1,311 2,620
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -1,875 1,875
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -653 0
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -312 0
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units A - Award D 7,537 7,537
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 1,594 14,072
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 1,311 12,990
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 1,875 12,412
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 653 10,793
2017-01-18 2017-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 312 10,262
2017-01-18 2017-01-17 4 Monia Brett P IONS Common Stock S - Sale D 46.2900 -623 -29 11,772
2017-01-18 2017-01-17 4 Monia Brett P IONS Common Stock S - Sale D 46.2910 -593 -27 10,801
2017-01-18 2017-01-17 4 Monia Brett P IONS Common Stock S - Sale D 46.2910 -733 -34 9,876
2017-01-18 2017-01-17 4 Monia Brett P IONS Common Stock S - Sale D 46.2900 -553 -26 8,734
2017-01-18 2017-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,594 4,779
2017-01-18 2017-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,518 3,034
2017-01-18 2017-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,875 1,875
2017-01-18 2017-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,415 0
2017-01-18 2017-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 8,000 8,000
2017-01-18 2017-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,594 12,395
2017-01-18 2017-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,518 11,394
2017-01-18 2017-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,875 10,609
2017-01-18 2017-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,415 9,287
2017-01-18 2017-01-17 4 Boyce Sarah IONS Common Stock S - Sale D 46.2900 -506 -23 5,252
2017-01-18 2017-01-17 4 Boyce Sarah IONS Common Stock S - Sale D 46.2900 -855 -40 4,463
2017-01-18 2017-01-15 4 Boyce Sarah IONS Restricted Stock Units M - Exercise D -1,295 3,883
2017-01-18 2017-01-15 4 Boyce Sarah IONS Restricted Stock Units M - Exercise D -2,188 4,374
2017-01-18 2017-01-15 4 Boyce Sarah IONS Restricted Stock Units A - Award D 7,537 7,537
2017-01-18 2017-01-15 4 Boyce Sarah IONS Common Stock M - Exercise D 1,295 5,758
2017-01-18 2017-01-15 4 Boyce Sarah IONS Common Stock M - Exercise D 2,188 5,318
2017-01-18 2017-01-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 46.2900 -131 -6 3,062
2017-01-18 2017-01-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 46.2910 -142 -7 2,859
2017-01-18 2017-01-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 46.2900 -139 -6 2,638
2017-01-18 2017-01-17 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 46.2910 -163 -8 2,423
2017-01-18 2017-01-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 46.2900 -4,410 -204 38,014
2017-01-18 2017-01-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 46.2900 -3,728 -173 34,291
2017-01-18 2017-01-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 46.2890 -4,236 -196 31,144
2017-01-18 2017-01-17 4 CROOKE STANLEY T IONS Common Stock S - Sale D 46.2890 -3,008 -139 27,568
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -334 999
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -363 724
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -354 354
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -416 0
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -8,133 24,397
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -6,875 13,750
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -7,812 7,812
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -5,547 0
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units A - Award I 2,692 2,692
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units A - Award D 27,168 27,168
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 334 3,193
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 363 3,001
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 354 2,777
2017-01-18 2017-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 416 2,586
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 8,133 42,424
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 6,875 38,019
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7,812 35,380
2017-01-18 2017-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 5,547 30,576
2017-01-12 2017-01-10 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,200 2,600
2017-01-12 2017-01-10 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -12,000 64,462
2017-01-12 2017-01-10 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 49.2500 -1,200 -59 2,170
2017-01-12 2017-01-10 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,200 12 3,370
2017-01-12 2017-01-10 4 CROOKE STANLEY T IONS Common Stock S - Sale D 49.2500 -12,000 -591 25,029
2017-01-12 2017-01-10 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 12,000 87 37,029
2017-01-04 2017-01-03 4 Geary Richard S IONS Employee Stock Option (right to buy) A - Award D 47.34 45,225 45,225
2017-01-04 2017-01-01 4 Geary Richard S IONS Common Stock J - Other D 20.7570 640 13 9,157
2017-01-04 2017-01-03 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) A - Award D 47.34 117,638 117,638
2017-01-04 2017-01-01 4 PARSHALL B LYNNE IONS Common Stock J - Other D 20.7570 171 4 16,864
2017-01-04 2017-01-03 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) A - Award D 47.34 45,225 45,225
2017-01-04 2017-01-01 4 BENNETT C FRANK IONS Common Stock J - Other D 20.7570 211 4 11,014
2017-01-04 2017-01-03 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) A - Award D 47.34 45,225 45,225
2017-01-04 2017-01-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 20.7570 199 4 6,747
2017-01-04 2017-01-03 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) A - Award D 47.34 45,225 45,225
2017-01-04 2017-01-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 20.7570 424 9 9,950
2017-01-04 2017-01-03 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 47.34 48,000 48,000
2017-01-04 2017-01-03 4 Monia Brett P IONS Common Stock S - Sale D 48.6000 -309 -15 7,872
2017-01-04 2017-01-01 4 Monia Brett P IONS Common Stock J - Other D 20.7570 309 6 8,181
2017-01-04 2017-01-03 4 Boyce Sarah IONS Employee Stock Option (right to buy) A - Award D 47.34 45,225 45,225
2017-01-04 2017-01-01 4 Boyce Sarah IONS Common Stock J - Other D 20.7570 992 21 3,130
2017-01-04 2017-01-04 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -700 3,800
2017-01-04 2017-01-04 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -7,000 76,462
2017-01-04 2017-01-04 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 50.1000 -700 -35 2,170
2017-01-04 2017-01-04 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 700 7 2,870
2017-01-04 2017-01-04 4 CROOKE STANLEY T IONS Common Stock S - Sale D 50.1000 -7,000 -351 25,029
2017-01-04 2017-01-04 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 7,000 51 32,029
2017-01-04 2017-01-03 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,000 4,500
2017-01-04 2017-01-03 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -10,000 83,462
2017-01-04 2017-01-03 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) A - Award I 47.34 16,157 16,157
2017-01-04 2017-01-03 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) A - Award D 47.34 163,013 163,013
2017-01-04 2017-01-03 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 48.8000 -500 -24 2,170
2017-01-04 2017-01-03 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 500 5 2,670
2017-01-04 2017-01-03 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 500 5 2,670
2017-01-04 2017-01-03 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 47.3000 -500 -24 2,170
2017-01-04 2017-01-03 4 CROOKE STANLEY T IONS Common Stock S - Sale D 48.8000 -5,000 -244 25,029
2017-01-04 2017-01-03 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 5,000 36 30,029
2017-01-04 2017-01-03 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 5,000 36 30,029
2017-01-04 2017-01-03 4 CROOKE STANLEY T IONS Common Stock S - Sale D 47.3000 -5,000 -236 25,029
2016-12-20 2016-12-20 4 Monia Brett P IONS Common Stock S - Sale D 52.4800 -130 -7 7,872
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By grandchild IONS Common Stock S - Sale I 50.0000 -1,000 -50 20,693
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By grandchild IONS Common Stock M - Exercise I 7.2500 1,000 7 20,693
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By daughter IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,000 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By grandchild IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,000 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By son-in-law IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,000 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By daughter IONS Employee Stock Option (right to buy) M - Exercise I 7.25 -1,000 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By daughter IONS Common Stock S - Sale I 50.0000 -1,000 -50 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By daughter IONS Common Stock S - Sale I 50.0000 -1,000 -50 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By son-in-law IONS Common Stock S - Sale I 50.0000 -1,000 -50 0
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By daughter IONS Common Stock M - Exercise I 7.2500 1,000 7 1,000
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By son-in-law IONS Common Stock M - Exercise I 7.2500 1,000 7 1,000
2016-12-16 2016-12-15 4 PARSHALL B LYNNE By daughter IONS Common Stock M - Exercise I 7.2500 1,000 7 1,000
2016-12-07 2016-12-05 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -350 2,344
2016-12-07 2016-12-05 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.0000 -350 -16 9,526
2016-12-07 2016-12-05 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 350 4 9,876
2016-12-07 2016-12-05 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,500 0
2016-12-07 2016-12-05 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 46.0500 -2,500 -115 6,548
2016-12-07 2016-12-05 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 11.2700 2,500 28 9,048
2016-12-02 2016-12-01 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -12,500 12,410
2016-12-02 2016-12-01 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 43.1700 -5,500 -237 16,693
2016-12-02 2016-12-01 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 14.6900 5,500 81 22,193
2016-12-02 2016-12-01 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 41.4900 -7,000 -290 16,693
2016-12-02 2016-12-01 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 14.6900 7,000 103 23,693
2016-11-16 2016-11-14 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,500 2,500
2016-11-16 2016-11-14 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 47.5000 -2,500 -119 6,548
2016-11-16 2016-11-14 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 11.2700 2,500 28 9,048
2016-11-14 2016-11-09 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 11.27 -22,805 0
2016-11-14 2016-11-09 4 BENNETT C FRANK IONS Common Stock S - Sale D 38.5400 -17,805 -686 10,803
2016-11-14 2016-11-09 4 BENNETT C FRANK IONS Common Stock M - Exercise D 11.2700 17,805 201 28,608
2016-11-14 2016-11-09 4 BENNETT C FRANK IONS Common Stock S - Sale D 34.0800 -5,000 -170 10,803
2016-11-14 2016-11-09 4 BENNETT C FRANK IONS Common Stock M - Exercise D 11.2700 5,000 56 15,803
2016-11-14 2016-11-11 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,500 5,000
2016-11-14 2016-11-11 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 41.0000 -2,500 -102 6,548
2016-11-14 2016-11-11 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 11.2700 2,500 28 9,048
2016-11-14 2016-11-09 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,500 7,500
2016-11-14 2016-11-09 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 38.4900 -2,500 -96 6,548
2016-11-14 2016-11-09 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 11.2700 2,500 28 9,048
2016-11-14 2016-11-14 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -806 2,694
2016-11-14 2016-11-14 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -194 4,907
2016-11-14 2016-11-14 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.0000 -806 -36 9,526
2016-11-14 2016-11-14 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 806 9 10,332
2016-11-14 2016-11-14 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.0000 -194 -9 9,526
2016-11-14 2016-11-14 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 194 2 9,720
2016-11-14 2016-11-10 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,000 5,500
2016-11-14 2016-11-10 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -10,000 93,462
2016-11-14 2016-11-10 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 42.2200 -1,000 -42 2,170
2016-11-14 2016-11-10 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,000 10 3,170
2016-11-14 2016-11-10 4 CROOKE STANLEY T IONS Common Stock S - Sale D 40.2300 -10,000 -402 25,029
2016-11-14 2016-11-10 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 10,000 72 35,029
2016-11-14 2016-11-09 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -2,000 6,500
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -3,741 103,462
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -16,259 0
2016-11-14 2016-11-09 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 37.2500 -1,000 -37 2,170
2016-11-14 2016-11-09 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,000 10 3,170
2016-11-14 2016-11-09 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,000 10 3,170
2016-11-14 2016-11-09 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 35.1000 -1,000 -35 2,170
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Common Stock S - Sale D 37.5000 -3,741 -140 25,029
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7.2500 3,741 27 28,770
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Common Stock S - Sale D 37.1000 -6,259 -232 25,029
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 6,259 64 31,288
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Common Stock S - Sale D 35.5500 -10,000 -356 25,029
2016-11-14 2016-11-09 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 10,000 103 35,029
2016-11-09 2016-11-07 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) M - Exercise D 11.27 -5,000 22,805
2016-11-09 2016-11-07 4 BENNETT C FRANK IONS Common Stock S - Sale D 34.0000 -5,000 -170 10,803
2016-11-09 2016-11-07 4 BENNETT C FRANK IONS Common Stock M - Exercise D 11.2700 5,000 56 15,803
2016-10-07 2016-10-05 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,000 8,500
2016-10-07 2016-10-05 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,000 16,259
2016-10-07 2016-10-05 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 36.6100 -1,000 -37 2,170
2016-10-07 2016-10-05 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 1,000 10 3,170
2016-10-07 2016-10-05 4 CROOKE STANLEY T IONS Common Stock S - Sale D 36.6100 -10,000 -366 25,029
2016-10-07 2016-10-05 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 10,000 103 35,029
2016-09-29 2016-09-27 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -2,000 9,500
2016-09-29 2016-09-27 4 CROOKE STANLEY T IONS Empoyee Stock Option (right to buy) M - Exercise D 10.29 -20,000 26,259
2016-09-29 2016-09-27 4 CROOKE STANLEY T By Wife IONS Common Stock S - Sale I 36.0500 -2,000 -72 2,170
2016-09-29 2016-09-27 4 CROOKE STANLEY T By Wife IONS Common Stock M - Exercise I 10.2900 2,000 21 4,170
2016-09-29 2016-09-27 4 CROOKE STANLEY T IONS Common Stock S - Sale D 36.0200 -20,000 -720 25,029
2016-09-29 2016-09-27 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 20,000 206 45,029
2016-09-23 2016-09-21 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -2,000 11,500
2016-09-23 2016-09-21 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -20,000 46,259
2016-09-23 2016-09-21 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 35.5000 -2,000 -71 2,170
2016-09-23 2016-09-21 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 2,000 21 4,170
2016-09-23 2016-09-21 4 CROOKE STANLEY T IONS Common Stock S - Sale D 35.5000 -20,000 -710 25,029
2016-09-23 2016-09-21 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 20,000 206 45,029
2016-09-06 2016-09-01 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -3,635 24,910
2016-09-06 2016-09-01 4 PARSHALL B LYNNE IONS Employee Stock Options (right to buy) M - Exercise D 7.25 -8,865 0
2016-09-06 2016-09-01 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 30.0500 -3,635 -109 16,693
2016-09-06 2016-09-01 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 14.6900 3,635 53 20,328
2016-09-06 2016-09-01 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 29.8154 -8,865 -264 16,693
2016-09-06 2016-09-01 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 7.2500 8,865 64 25,558
2016-07-06 2016-07-02 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -312 0
2016-07-06 2016-07-02 4 WENDER JOSEPH H By Joseph H Wender Trust IONS Common Stock M - Exercise I 312 33,780
2016-07-06 2016-07-01 4 WENDER JOSEPH H IONS Director Stock Option (right to buy) A - Award D 24.42 16,000 16,000
2016-07-06 2016-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units A - Award D 2,667 2,667
2016-07-06 2016-07-01 4 WENDER JOSEPH H IONS Restricted Stock Units M - Exercise D -1,803 3,801
2016-07-06 2016-07-01 4 WENDER JOSEPH H By Joseph H Wender Trust IONS Common Stock M - Exercise I 469 33,468
2016-07-06 2016-07-01 4 WENDER JOSEPH H By Joseph H Wender Trust IONS Common Stock M - Exercise I 667 32,999
2016-07-06 2016-07-01 4 WENDER JOSEPH H By Joseph H Wender Trust IONS Common Stock M - Exercise I 667 32,999
2016-07-06 2016-07-01 4 Castleman Breaux IONS Director Stock Option (right to buy) A - Award D 24.42 16,000 16,000
2016-07-06 2016-07-01 4 Castleman Breaux IONS Restricted Stock Units A - Award D 2,667 2,667
2016-07-06 2016-07-01 4 Castleman Breaux IONS Restricted Stock Units M - Exercise D -2,740 4,738
2016-07-06 2016-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 667 6,221
2016-07-06 2016-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 667 6,221
2016-07-06 2016-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 937 5,554
2016-07-06 2016-07-01 4 Castleman Breaux IONS Common Stock M - Exercise D 469 3,950
2016-07-06 2016-07-02 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -312 0
2016-07-06 2016-07-02 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 312 7,658
2016-07-06 2016-07-01 4 KLEIN JOSEPH III IONS Director Stock Option (right to buy) A - Award D 24.42 16,000 16,000
2016-07-06 2016-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units A - Award D 2,667 2,667
2016-07-06 2016-07-01 4 KLEIN JOSEPH III IONS Restricted Stock Units M - Exercise D -1,803 3,801
2016-07-06 2016-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 469 7,346
2016-07-06 2016-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 667 6,877
2016-07-06 2016-07-01 4 KLEIN JOSEPH III IONS Common Stock M - Exercise D 667 6,877
2016-07-06 2016-07-01 4 LOSCALZO JOSEPH IONS Director Stock Option (right to buy) A - Award D 24.42 16,000 16,000
2016-07-06 2016-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units A - Award D 2,667 2,667
2016-07-06 2016-07-01 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -1,334 3,333
2016-07-06 2016-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 667 3,877
2016-07-06 2016-07-01 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 667 3,877
2016-07-06 2016-07-02 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -312 0
2016-07-06 2016-07-02 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 312 4,658
2016-07-06 2016-07-01 4 MUTO FREDERICK T IONS Director Stock Option (right to buy) A - Award D 24.42 16,000 16,000
2016-07-06 2016-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units A - Award D 2,667 2,667
2016-07-06 2016-07-01 4 MUTO FREDERICK T IONS Restricted Stock Units M - Exercise D -1,803 3,801
2016-07-06 2016-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 469 4,346
2016-07-06 2016-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 667 3,877
2016-07-06 2016-07-01 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 667 3,877
2016-07-06 2016-07-02 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -312 0
2016-07-06 2016-07-02 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 312 76,458
2016-07-06 2016-07-01 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) A - Award D 24.42 16,000 16,000
2016-07-06 2016-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units A - Award D 2,667 2,667
2016-07-06 2016-07-01 4 BERTHELSEN SPENCER R IONS Restricted Stock Units M - Exercise D -1,803 3,801
2016-07-06 2016-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 667 76,146
2016-07-06 2016-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 667 76,146
2016-07-06 2016-07-01 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 469 74,812
2016-07-01 2016-07-01 4 BENNETT C FRANK IONS Common Stock J - Other D 20.7570 213 4 10,803
2016-07-01 2016-07-01 4 Boyce Sarah IONS Common Stock J - Other D 20.7570 403 8 2,138
2016-07-01 2016-07-01 4 Geary Richard S IONS Common Stock J - Other D 20.7570 163 3 8,517
2016-07-01 2016-07-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 20.7570 217 5 6,548
2016-07-01 2016-07-01 4 Monia Brett P IONS Common Stock J - Other D 20.7570 309 6 8,002
2016-07-01 2016-07-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 20.7570 402 8 9,526
2016-07-01 2016-07-01 4 PARSHALL B LYNNE IONS Common Stock J - Other D 20.7570 403 8 16,693
2016-06-02 2016-05-31 4 MUTO FREDERICK T IONS Director Stock Option (right to buy) M - Exercise D 5.93 -12,500 0
2016-06-02 2016-05-31 4 MUTO FREDERICK T IONS Common Stock S - Sale D 22.3120 -12,500 -279 2,543
2016-06-02 2016-05-31 4 MUTO FREDERICK T IONS Common Stock M - Exercise D 5.9300 12,500 74 15,043
2016-04-07 2016-04-06 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,000 5,101
2016-04-07 2016-04-06 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.0000 -1,000 -45 9,124
2016-04-07 2016-04-06 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 1,000 11 10,124
2016-04-07 2016-04-06 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -1,000 13,500
2016-04-07 2016-04-06 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,000 66,259
2016-04-07 2016-04-06 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 46.3000 -500 -23 2,170
2016-04-07 2016-04-06 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 500 5 2,670
2016-04-07 2016-04-06 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 500 5 2,670
2016-04-07 2016-04-06 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 45.9500 -500 -23 2,170
2016-04-07 2016-04-06 4 CROOKE STANLEY T IONS Common Stock S - Sale D 46.3000 -5,000 -232 25,029
2016-04-07 2016-04-06 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 5,000 51 30,029
2016-04-07 2016-04-06 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 5,000 51 30,029
2016-04-07 2016-04-06 4 CROOKE STANLEY T IONS Common Stock S - Sale D 45.9500 -5,000 -230 25,029
2016-04-01 2016-03-31 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 10.29 -500 14,500
2016-04-01 2016-03-31 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 9.22 -500 14,500
2016-04-01 2016-03-31 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,000 76,259
2016-04-01 2016-03-31 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 40.7500 -500 -20 2,170
2016-04-01 2016-03-31 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 10.2900 500 5 2,670
2016-04-01 2016-03-31 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 40.7200 -500 -20 2,170
2016-04-01 2016-03-31 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 9.2200 500 5 2,670
2016-04-01 2016-03-31 4 CROOKE STANLEY T IONS Common Stock S - Sale D 40.7200 -5,000 -204 25,029
2016-04-01 2016-03-31 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 5,000 51 30,029
2016-04-01 2016-03-31 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 5,000 51 30,029
2016-04-01 2016-03-31 4 CROOKE STANLEY T IONS Common Stock S - Sale D 40.7500 -5,000 -204 25,029
2016-03-24 2016-03-23 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,000 6,101
2016-03-24 2016-03-23 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 45.4000 -1,000 -45 9,124
2016-03-24 2016-03-23 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 1,000 11 10,124
2016-02-22 2016-02-19 4 BERTHELSEN SPENCER R IONS Director Stock Option (right to buy) M - Exercise D 5.93 -12,500 0
2016-02-22 2016-02-19 4 BERTHELSEN SPENCER R IONS Common Stock M - Exercise D 5.9300 12,500 74 74,343
2016-02-04 2016-02-03 4 LOSCALZO JOSEPH IONS Restricted Stock Units M - Exercise D -938 1,874
2016-02-04 2016-02-03 4 LOSCALZO JOSEPH IONS Common Stock M - Exercise D 938 2,543
2016-01-19 2016-01-19 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 41.4600 -145 -6 2,170
2016-01-19 2016-01-19 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 41.4633 -141 -6 1,952
2016-01-19 2016-01-19 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 41.4626 -166 -7 1,739
2016-01-19 2016-01-19 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 41.4610 -124 -5 1,489
2016-01-19 2016-01-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 41.4655 -3,798 -157 25,029
2016-01-19 2016-01-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 41.4551 -4,317 -179 21,952
2016-01-19 2016-01-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 41.4582 -3,065 -127 18,456
2016-01-19 2016-01-19 4 CROOKE STANLEY T IONS Common Stock S - Sale D 41.4582 -1,645 -68 15,974
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -363 1,087
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -354 708
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -416 416
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units M - Exercise I -316 0
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -6,875 20,625
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -7,813 15,624
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -5,547 5,547
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units M - Exercise D -2,977 0
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Restricted Stock Units A - Award I 1,333 1,333
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Restricted Stock Units A - Award D 32,530 32,530
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 363 2,315
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 354 2,093
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 416 1,905
2016-01-19 2016-01-15 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 316 1,613
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 6,875 28,827
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 7,813 26,269
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 5,547 21,521
2016-01-19 2016-01-15 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 2,977 17,619
2016-01-19 2016-01-19 4 Boyce Sarah IONS Common Stock S - Sale D 41.4574 -872 -36 1,735
2016-01-19 2016-01-15 4 Boyce Sarah IONS Restricted Stock Units M - Exercise D -2,188 6,562
2016-01-19 2016-01-15 4 Boyce Sarah IONS Restricted Stock Units A - Award D 5,178 5,178
2016-01-19 2016-01-15 4 Boyce Sarah IONS Common Stock M - Exercise D 2,188 2,607
2016-01-19 2016-01-19 4 Monia Brett P IONS Common Stock S - Sale D 41.4583 -604 -25 7,693
2016-01-19 2016-01-19 4 Monia Brett P IONS Common Stock S - Sale D 41.4580 -747 -31 6,779
2016-01-19 2016-01-19 4 Monia Brett P IONS Common Stock S - Sale D 41.4583 -564 -23 5,651
2016-01-19 2016-01-19 4 Monia Brett P IONS Common Stock S - Sale D 41.4651 -83 -3 4,800
2016-01-19 2016-01-19 4 Monia Brett P IONS Common Stock S - Sale D 41.4632 -210 -9 4,675
2016-01-19 2016-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,518 4,552
2016-01-19 2016-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,875 3,750
2016-01-19 2016-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -1,415 1,415
2016-01-19 2016-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -208 0
2016-01-19 2016-01-15 4 Monia Brett P IONS Restricted Stock Units M - Exercise D -527 0
2016-01-19 2016-01-15 4 Monia Brett P IONS Restricted Stock Units A - Award D 6,373 6,373
2016-01-19 2016-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,518 8,297
2016-01-19 2016-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,875 7,526
2016-01-19 2016-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 1,415 6,215
2016-01-19 2016-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 208 4,883
2016-01-19 2016-01-15 4 Monia Brett P IONS Common Stock M - Exercise D 527 4,885
2016-01-19 2016-01-19 4 Geary Richard S IONS Common Stock S - Sale D 41.4573 -550 -23 8,354
2016-01-19 2016-01-19 4 Geary Richard S IONS Common Stock S - Sale D 41.4554 -747 -31 7,524
2016-01-19 2016-01-19 4 Geary Richard S IONS Common Stock S - Sale D 41.4674 -556 -23 6,396
2016-01-19 2016-01-19 4 Geary Richard S IONS Common Stock S - Sale D 41.4559 -309 -13 5,555
2016-01-19 2016-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,380 4,138
2016-01-19 2016-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,875 3,750
2016-01-19 2016-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -1,397 1,397
2016-01-19 2016-01-15 4 Geary Richard S IONS Restricted Stock Units M - Exercise D -775 0
2016-01-19 2016-01-15 4 Geary Richard S IONS Restricted Stock Units A - Award D 6,373 6,373
2016-01-19 2016-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,380 8,904
2016-01-19 2016-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,875 8,271
2016-01-19 2016-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 1,397 6,952
2016-01-19 2016-01-15 4 Geary Richard S IONS Common Stock M - Exercise D 775 5,864
2016-01-19 2016-01-19 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 41.4588 -522 -22 9,124
2016-01-19 2016-01-19 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 41.4653 -747 -31 8,335
2016-01-19 2016-01-19 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 41.4592 -261 -11 7,207
2016-01-19 2016-01-19 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 41.4589 -125 -5 6,814
2016-01-19 2016-01-19 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 41.4563 -216 -9 6,627
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -1,311 3,931
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -1,875 3,750
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -654 653
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -312 312
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units M - Exercise D -541 0
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Restricted Stock Units A - Award D 6,373 6,373
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 1,311 9,646
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 1,875 9,082
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 654 7,468
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 312 6,939
2016-01-19 2016-01-15 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 541 6,843
2016-01-19 2016-01-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 41.4656 -550 -23 6,331
2016-01-19 2016-01-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 41.4661 -747 -31 5,501
2016-01-19 2016-01-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 41.4634 -261 -11 4,373
2016-01-19 2016-01-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 41.4581 -125 -5 3,980
2016-01-19 2016-01-19 4 HOUGEN ELIZABETH L IONS Common Stock S - Sale D 41.4655 -216 -9 3,793
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -1,380 4,138
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Unit M - Exercise D -1,875 3,750
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -654 653
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -312 312
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units M - Exercise D -541 0
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Restricted Stock Units A - Award D 6,373 6,373
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 1,380 6,881
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 1,875 6,248
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 654 4,634
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 312 4,105
2016-01-19 2016-01-15 4 HOUGEN ELIZABETH L IONS Common Stock M - Exercise D 541 4,009
2016-01-19 2016-01-19 4 BENNETT C FRANK IONS Common Stock S - Sale D 41.4562 -522 -22 10,590
2016-01-19 2016-01-19 4 BENNETT C FRANK IONS Common Stock S - Sale D 41.4555 -747 -31 9,801
2016-01-19 2016-01-19 4 BENNETT C FRANK IONS Common Stock S - Sale D 41.4588 -564 -23 8,673
2016-01-19 2016-01-19 4 BENNETT C FRANK IONS Common Stock S - Sale D 41.4579 -277 -11 7,822
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,311 3,931
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,875 3,750
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -1,415 1,415
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Restricted Stock Units M - Exercise D -694 0
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Restricted Stock Units A - Award D 6,373 6,373
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,311 11,112
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,875 10,548
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 1,415 9,237
2016-01-19 2016-01-15 4 BENNETT C FRANK IONS Common Stock M - Exercise D 694 8,099
2016-01-19 2016-01-19 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 41.4584 -2,303 -95 16,290
2016-01-19 2016-01-19 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 41.4556 -1,219 -51 13,074
2016-01-19 2016-01-19 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 41.4658 -1,003 -42 10,855
2016-01-19 2016-01-19 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 41.4594 -667 -28 9,263
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -5,519 16,557
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -3,438 6,874
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -2,595 2,595
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units M - Exercise D -1,715 0
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Restricted Stock Units A - Award D 17,925 17,925
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 5,519 18,593
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 3,438 14,293
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 2,595 11,858
2016-01-19 2016-01-15 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 1,715 9,930
2016-01-07 2016-01-05 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 9.22 -500 500
2016-01-07 2016-01-05 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -5,000 86,259
2016-01-07 2016-01-05 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 62.1000 -500 -31 1,297
2016-01-07 2016-01-05 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 9.2200 500 5 1,797
2016-01-07 2016-01-05 4 CROOKE STANLEY T IONS Common Stock S - Sale D 62.1000 -5,000 -310 14,642
2016-01-07 2016-01-05 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 5,000 51 19,642
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 7.25 -848 1,219
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) M - Exercise D 10.82 -152 7,101
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Employee Stock Option (right to buy) A - Award D 61.68 38,240 38,240
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 61.1000 -848 -52 6,302
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 7.2500 848 6 7,150
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Common Stock S - Sale D 61.1000 -152 -9 6,302
2016-01-04 2016-01-04 4 O'NEIL PATRICK R. IONS Common Stock M - Exercise D 10.8200 152 2 6,454
2016-01-04 2016-01-01 4 O'NEIL PATRICK R. IONS Common Stock J - Other D 47.7105 43 2 6,302
2016-01-04 2016-01-04 4 Monia Brett P IONS Employee Stock Option (right to buy) A - Award D 61.68 38,240 38,240
2016-01-04 2016-01-04 4 Monia Brett P IONS Common Stock S - Sale D 61.0000 -127 -8 4,358
2016-01-04 2016-01-01 4 Monia Brett P IONS Common Stock J - Other D 47.7105 130 6 4,485
2016-01-04 2016-01-04 4 CROOKE STANLEY T By wife IONS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,000 1,000
2016-01-04 2016-01-04 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,000 91,259
2016-01-04 2016-01-04 4 CROOKE STANLEY T By Wife IONS Employee Stock Option (right to buy) A - Award I 61.68 8,000 8,000
2016-01-04 2016-01-04 4 CROOKE STANLEY T IONS Employee Stock Option (right to buy) A - Award D 61.68 195,182 195,182
2016-01-04 2016-01-04 4 CROOKE STANLEY T By wife IONS Common Stock S - Sale I 61.0500 -1,000 -61 1,297
2016-01-04 2016-01-04 4 CROOKE STANLEY T By wife IONS Common Stock M - Exercise I 9.2200 1,000 9 2,297
2016-01-04 2016-01-04 4 CROOKE STANLEY T IONS Common Stock S - Sale D 61.0500 -10,000 -610 14,642
2016-01-04 2016-01-04 4 CROOKE STANLEY T IONS Common Stock M - Exercise D 10.2900 10,000 103 24,642
2016-01-04 2016-01-04 4 Boyce Sarah IONS Employee Stock Option (right to buy) A - Award D 61.68 31,070 31,070
2016-01-04 2016-01-01 4 Boyce Sarah IONS Common Stock J - Other D 47.7105 419 20 419
2016-01-04 2016-01-04 4 Geary Richard S IONS Employee Stock Option (right to buy) A - Award D 61.68 38,240 38,240
2016-01-04 2016-01-01 4 Geary Richard S IONS Common Stock J - Other D 47.7105 269 13 5,089
2016-01-04 2016-01-04 4 HOUGEN ELIZABETH L IONS Employee Stock Option (right to buy) A - Award D 61.68 38,240 38,240
2016-01-04 2016-01-01 4 HOUGEN ELIZABETH L IONS Common Stock J - Other D 47.7105 41 2 3,468
2016-01-04 2016-01-04 4 BENNETT C FRANK IONS Employee Stock Option (right to buy) A - Award D 61.68 38,240 38,240
2016-01-04 2016-01-01 4 BENNETT C FRANK IONS Common Stock J - Other D 47.7105 89 4 7,405
2016-01-04 2016-01-04 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) M - Exercise D 14.69 -809 28,545
2016-01-04 2016-01-04 4 PARSHALL B LYNNE IONS Employee Stock Option (right to buy) A - Award D 61.68 107,549 107,549
2016-01-04 2016-01-04 4 PARSHALL B LYNNE IONS Common Stock S - Sale D 61.0500 -809 -49 8,215
2016-01-04 2016-01-04 4 PARSHALL B LYNNE IONS Common Stock M - Exercise D 14.6900 809 12 9,024
2016-01-04 2016-01-01 4 PARSHALL B LYNNE IONS Common Stock J - Other D 47.7105 72 3 8,215
2015-12-17 2015-12-16 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -3,909 0
2015-12-17 2015-12-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 58.8500 -3,909 -230 7,316
2015-12-17 2015-12-16 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 3,909 57 11,225
2015-12-17 2015-12-15 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -4,000 3,909
2015-12-17 2015-12-15 4 BENNETT C FRANK ISIS Common Stock S - Sale D 56.0000 -4,000 -224 7,316
2015-12-17 2015-12-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 4,000 58 11,316
2015-12-02 2015-12-01 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -1,000 2,067
2015-12-02 2015-12-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 61.5000 -1,000 -62 6,259
2015-12-02 2015-12-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 1,000 7 7,259
2015-11-12 2015-11-10 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -5,000 7,909
2015-11-12 2015-11-10 4 BENNETT C FRANK ISIS Common Stock S - Sale D 64.0000 -5,000 -320 7,316
2015-11-12 2015-11-10 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 5,000 72 12,316
2015-11-12 2015-11-11 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 12.94 -3,125 2,812
2015-11-12 2015-11-11 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 9.30 -3,750 0
2015-11-12 2015-11-11 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 64.1795 -3,125 -201 5,543
2015-11-12 2015-11-11 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 12.9400 3,125 40 8,668
2015-11-12 2015-11-11 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 64.1795 -3,750 -241 5,543
2015-11-12 2015-11-11 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 9.3000 3,750 35 9,293
2015-11-09 2015-11-06 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -5,000 12,909
2015-11-09 2015-11-06 4 BENNETT C FRANK ISIS Common Stock S - Sale D 56.0000 -5,000 -280 7,316
2015-11-09 2015-11-06 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 5,000 72 12,316
2015-11-09 2015-11-09 4 PARSHALL B LYNNE By grandchild ISIS Employee Stock Option (right to buy) G - Gift I 7.25 1,000 1,000
2015-11-09 2015-11-09 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 7.25 1,000 1,000
2015-11-09 2015-11-09 4 PARSHALL B LYNNE By son-in-Law ISIS Employee Stock Option (right to buy) G - Gift I 7.25 1,000 1,000
2015-11-09 2015-11-09 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 7.25 1,000 1,000
2015-11-09 2015-11-09 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) G - Gift D 7.25 -4,000 8,865
2015-11-04 2015-11-03 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -1,000 3,067
2015-11-04 2015-11-03 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 51.9500 -1,000 -52 6,259
2015-11-04 2015-11-03 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 1,000 7 7,259
2015-10-23 2015-10-23 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -2,500 2,000
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -20,837 101,259
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -4,163 0
2015-10-23 2015-10-23 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 45.3000 -500 -23 1,297
2015-10-23 2015-10-23 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 500 5 1,797
2015-10-23 2015-10-23 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 44.1750 -2,000 -88 1,297
2015-10-23 2015-10-23 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 2,000 18 3,297
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 45.3000 -5,000 -226 14,642
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 10.2900 5,000 51 19,642
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 44.1750 -15,837 -700 14,642
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 10.2900 15,837 163 30,479
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 43.9000 -4,163 -183 14,642
2015-10-23 2015-10-23 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 4,163 47 18,805
2015-10-23 2015-10-21 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -500 4,500
2015-10-23 2015-10-21 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 11.27 -1,000 0
2015-10-23 2015-10-21 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -15,000 4,163
2015-10-23 2015-10-21 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 43.0000 -500 -22 1,297
2015-10-23 2015-10-21 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 500 5 1,797
2015-10-23 2015-10-21 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 43.0000 -1,000 -43 1,297
2015-10-23 2015-10-21 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 11.2700 1,000 11 2,297
2015-10-23 2015-10-21 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 43.0000 -15,000 -645 14,642
2015-10-23 2015-10-21 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 15,000 169 29,642
2015-10-05 2015-10-02 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -5,436 29,354
2015-10-05 2015-10-02 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 42.3944 -3,436 -146 8,143
2015-10-05 2015-10-02 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 3,436 50 11,579
2015-10-05 2015-10-02 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.1000 -2,000 -80 8,143
2015-10-05 2015-10-02 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 2,000 29 10,143
2015-10-05 2015-10-01 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -2,838 34,790
2015-10-05 2015-10-01 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -4,162 12,865
2015-10-05 2015-10-01 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.1257 -2,838 -114 8,143
2015-10-05 2015-10-01 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 2,838 42 10,981
2015-10-05 2015-10-01 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.1257 -4,162 -167 8,143
2015-10-05 2015-10-01 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 7.2500 4,162 30 12,305
2015-07-08 2015-07-06 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -4,843 17,027
2015-07-08 2015-07-06 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -1,375 0
2015-07-08 2015-07-06 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 57.0070 -4,843 -276 8,143
2015-07-08 2015-07-06 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 7.2500 4,843 35 12,986
2015-07-08 2015-07-06 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 57.0070 -1,375 -78 8,143
2015-07-08 2015-07-06 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 10.2900 1,375 14 9,518
2015-07-08 2015-07-06 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,175 5,000
2015-07-08 2015-07-06 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -5,000 19,163
2015-07-08 2015-07-06 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 57.0070 -1,175 -67 1,297
2015-07-08 2015-07-06 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 9.2200 1,175 11 2,472
2015-07-08 2015-07-06 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 57.0070 -5,000 -285 14,642
2015-07-08 2015-07-06 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 5,000 56 19,642
2015-07-02 2015-07-02 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units M - Exercise D -312 312
2015-07-02 2015-07-02 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 312 61,843
2015-07-02 2015-07-01 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) A - Award D 57.16 16,000 16,000
2015-07-02 2015-07-01 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units A - Award D 2,667 2,667
2015-07-02 2015-07-01 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units M - Exercise D -667 2,000
2015-07-02 2015-07-01 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units M - Exercise D -469 937
2015-07-02 2015-07-01 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 667 61,531
2015-07-02 2015-07-01 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 469 60,864
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Director Stock Option (right to buy) A - Award D 57.16 16,000 16,000
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Restricted Stock Units A - Award D 2,667 2,667
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Restricted Stock Units M - Exercise D -667 2,000
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Restricted Stock Units M - Exercise D -469 937
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Restricted Stock Units M - Exercise D -938 1,874
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Common Stock M - Exercise D 667 3,481
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Common Stock M - Exercise D 469 2,814
2015-07-02 2015-07-01 4 Castleman Breaux ISIS Common Stock M - Exercise D 938 2,345
2015-07-02 2015-07-02 4 KLEIN JOSEPH III ISIS Restricted Stock Units M - Exercise D -312 312
2015-07-02 2015-07-02 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 312 5,543
2015-07-02 2015-07-01 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) A - Award D 57.16 16,000 16,000
2015-07-02 2015-07-01 4 KLEIN JOSEPH III ISIS Restricted Stock Units A - Award D 2,667 2,667
2015-07-02 2015-07-01 4 KLEIN JOSEPH III ISIS Restricted Stock Units M - Exercise D -667 2,000
2015-07-02 2015-07-01 4 KLEIN JOSEPH III ISIS Restricted Stock Units M - Exercise D -469 937
2015-07-02 2015-07-01 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 667 5,231
2015-07-02 2015-07-01 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 469 4,564
2015-07-02 2015-07-01 4 LOSCALZO JOSEPH ISIS Director Stock Option (right to buy) A - Award D 57.16 16,000 16,000
2015-07-02 2015-07-01 4 LOSCALZO JOSEPH ISIS Restricted Stock Units A - Award D 2,667 2,667
2015-07-02 2015-07-01 4 LOSCALZO JOSEPH ISIS Restricted Stock Units M - Exercise D -667 2,000
2015-07-02 2015-07-01 4 LOSCALZO JOSEPH ISIS Common Stock M - Exercise D 667 1,605
2015-07-02 2015-07-02 4 MUTO FREDERICK T ISIS Restricted Stock Units M - Exercise D -312 312
2015-07-02 2015-07-02 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 312 2,543
2015-07-02 2015-07-01 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) A - Award D 57.16 16,000 16,000
2015-07-02 2015-07-01 4 MUTO FREDERICK T ISIS Restricted Stock Units A - Award D 2,667 2,667
2015-07-02 2015-07-01 4 MUTO FREDERICK T ISIS Restricted Stock Units M - Exercise D -667 2,000
2015-07-02 2015-07-01 4 MUTO FREDERICK T ISIS Restricted Stock Units M - Exercise D -469 937
2015-07-02 2015-07-01 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 667 2,231
2015-07-02 2015-07-01 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 469 1,564
2015-07-02 2015-07-02 4 WENDER JOSEPH H ISIS Restricted Stock Units M - Exercise D -312 312
2015-07-02 2015-07-02 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 312 31,665
2015-07-02 2015-07-01 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) A - Award D 57.16 16,000 16,000
2015-07-02 2015-07-01 4 WENDER JOSEPH H ISIS Restricted Stock Units A - Award D 2,667 2,667
2015-07-02 2015-07-01 4 WENDER JOSEPH H ISIS Restricted Stock Units M - Exercise D -667 2,000
2015-07-02 2015-07-01 4 WENDER JOSEPH H ISIS Restricted Stock Units M - Exercise D -469 937
2015-07-02 2015-07-01 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 667 31,353
2015-07-02 2015-07-01 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 469 30,686
2015-07-02 2015-07-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 48.5860 87 4 7,316
2015-07-02 2015-07-01 4 Geary Richard S ISIS Common Stock J - Other D 48.5860 265 13 4,820
2015-07-02 2015-07-01 4 HOUGEN ELIZABETH L ISIS Common Stock J - Other D 48.5860 40 2 3,427
2015-07-02 2015-07-02 4 Monia Brett P ISIS Common Stock S - Sale D 56.3000 -198 -11 4,355
2015-07-02 2015-07-01 4 Monia Brett P ISIS Common Stock J - Other D 48.5860 127 6 4,553
2015-07-02 2015-07-01 4 O'NEIL PATRICK R. ISIS Common Stock J - Other D 48.5860 85 4 6,259
2015-07-02 2015-07-01 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -6,218 1,375
2015-07-02 2015-07-01 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 57.5610 -6,218 -358 8,143
2015-07-02 2015-07-01 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 10.2900 6,218 64 14,361
2015-07-02 2015-07-01 4 PARSHALL B LYNNE ISIS Common Stock J - Other D 48.5860 71 3 8,143
2015-07-02 2015-07-01 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,175 6,175
2015-07-02 2015-07-01 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -5,000 24,163
2015-07-02 2015-07-01 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 57.5610 -1,175 -68 1,297
2015-07-02 2015-07-01 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 9.2200 1,175 11 2,472
2015-07-02 2015-07-01 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 57.5610 -5,000 -288 14,642
2015-07-02 2015-07-01 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 5,000 56 19,642
2015-06-10 2015-06-08 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -7,600 0
2015-06-10 2015-06-08 4 Monia Brett P ISIS Common Stock S - Sale D 66.2210 -7,600 -503 4,426
2015-06-10 2015-06-08 4 Monia Brett P ISIS Common Stock M - Exercise D 10.2900 7,600 78 12,026
2015-06-03 2015-06-01 4 MUTO FREDERICK T ISIS Non-Employee Director stock option (right to buy) M - Exercise D 3.95 -10,000 0
2015-06-03 2015-06-01 4 MUTO FREDERICK T ISIS Common Stock S - Sale D 66.9110 -10,000 -669 1,095
2015-06-03 2015-06-01 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 3.9500 10,000 40 11,095
2015-04-17 2015-04-17 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) M - Exercise D 3.95 10,000 0
2015-04-17 2015-04-17 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 3.9500 10,000 40 60,395
2015-04-08 2015-04-07 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -5,565 37,628
2015-04-08 2015-04-07 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 63.0710 -5,565 -351 8,072
2015-04-08 2015-04-07 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 5,565 82 13,637
2015-04-08 2015-04-07 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -2,034 7,350
2015-04-08 2015-04-07 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -20,343 29,163
2015-04-08 2015-04-07 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 63.0710 -2,034 -128 1,297
2015-04-08 2015-04-07 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 2,034 19 3,331
2015-04-08 2015-04-07 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 63.0710 -20,343 -1,283 14,642
2015-04-08 2015-04-07 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 20,343 229 34,985
2015-04-06 2015-04-01 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -5,377 43,193
2015-04-06 2015-04-01 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 61.9321 -5,377 -333 8,072
2015-04-06 2015-04-01 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 5,377 79 13,449
2015-04-06 2015-04-01 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,966 9,384
2015-04-06 2015-04-01 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -19,657 49,506
2015-04-06 2015-04-01 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 61.9321 -1,966 -122 1,297
2015-04-06 2015-04-01 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 1,966 18 3,263
2015-04-06 2015-04-01 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 61.9321 -19,657 -1,217 14,642
2015-04-06 2015-04-01 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 19,657 222 34,299
2015-03-25 2015-03-24 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -9,000 17,909
2015-03-25 2015-03-24 4 BENNETT C FRANK ISIS Common Stock S - Sale D 71.0100 -9,000 -639 7,229
2015-03-25 2015-03-24 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 9,000 130 16,229
2015-03-25 2015-03-23 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -6,000 26,909
2015-03-25 2015-03-23 4 BENNETT C FRANK ISIS Common Stock S - Sale D 71.0000 -1,000 -71 7,229
2015-03-25 2015-03-23 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 1,000 14 8,229
2015-03-25 2015-03-23 4 BENNETT C FRANK ISIS Common Stock S - Sale D 69.8040 -5,000 -349 7,229
2015-03-25 2015-03-23 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 14.4700 5,000 72 12,229
2015-03-20 2015-03-19 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -8,000 17,240
2015-03-20 2015-03-19 4 Geary Richard S ISIS Common Stock S - Sale D 75.0040 -8,000 -600 4,555
2015-03-20 2015-03-19 4 Geary Richard S ISIS Common Stock M - Exercise D 14.6900 8,000 118 12,555
2015-03-20 2015-03-19 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,000 10,000
2015-03-20 2015-03-19 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 73.3260 -10,000 -733 3,387
2015-03-20 2015-03-19 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 11.2700 10,000 113 13,387
2015-03-20 2015-03-18 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 5.93 -12,500 0
2015-03-20 2015-03-18 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 71.8443 -6,400 -460 30,217
2015-03-20 2015-03-18 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 5.9300 6,400 38 36,617
2015-03-20 2015-03-18 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 70.9480 -6,100 -433 30,217
2015-03-20 2015-03-18 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 5.9300 6,100 36 36,317
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 39.87 -13,125 31,875
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.82 -4,000 3,500
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.82 -6,100 7,253
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -5,683 4,067
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -1,617 0
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 75.0040 -10,525 -789 6,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 39.8700 10,525 420 16,699
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 74.7670 -2,600 -194 6,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 39.8700 2,600 104 8,774
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 74.7670 -4,000 -299 6,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.8200 4,000 43 10,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 74.7670 -6,100 -456 6,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.8200 6,100 66 12,274
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 74.7670 -5,683 -425 6,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 5,683 41 11,857
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 74.7670 -1,617 -121 6,174
2015-03-20 2015-03-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 1,617 17 7,791
2015-03-09 2015-03-05 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -4,133 1,617
2015-03-09 2015-03-05 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 8.00 -1,667 0
2015-03-09 2015-03-05 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 71.6680 -4,133 -296 6,174
2015-03-09 2015-03-05 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 4,133 43 10,307
2015-03-09 2015-03-05 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 71.6680 -1,667 -119 6,174
2015-03-09 2015-03-05 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 1,667 13 7,841
2015-03-09 2015-03-05 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -7,000 7,035
2015-03-09 2015-03-05 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -8,000 426
2015-03-09 2015-03-05 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -80 0
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock S - Sale D 70.3180 -7,000 -492 4,555
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock M - Exercise D 7.2500 7,000 51 11,555
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock S - Sale D 71.6680 -8,000 -573 4,555
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock M - Exercise D 10.2900 8,000 82 12,555
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock S - Sale D 71.6680 -80 -6 4,555
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock M - Exercise D 11.2700 80 1 4,635
2015-03-09 2015-03-05 4 Geary Richard S ISIS Common Stock S - Sale D 71.6680 -3,015 -216 4,555
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 12.94 -2,500 5,937
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 9.22 -3,750 3,750
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 9.30 -3,750 3,750
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 70.9545 -7,000 -497 4,095
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 12.9400 2,500 32 11,095
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 9.3000 3,750 35 8,595
2015-03-09 2015-03-05 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 9.2200 3,750 35 4,845
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -15,437 4,063
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -12,657 0
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 71.3160 -7,437 -530 3,387
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 7.2500 7,437 54 10,824
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 71.6680 -8,000 -573 3,387
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 7.2500 8,000 58 11,387
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 71.6680 -12,657 -907 3,387
2015-03-09 2015-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 14.4700 12,657 183 16,044
2015-03-09 2015-03-05 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 9.77 -12,500 0
2015-03-09 2015-03-05 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 71.6139 -12,500 -895 30,217
2015-03-09 2015-03-05 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 9.7700 12,500 122 42,717
2015-03-04 2015-03-02 4 WENDER JOSEPH H By Joseph H. Wender Trust ISIS Common Stock S - Sale I 65.9693 -7,000 -462 30,217
2015-02-17 2015-02-12 4 WENDER JOSEPH H By Trust ISIS Non-Employee Director Stock Option (right to buy) M - Exercise I 3.95 -10,000 0
2015-02-17 2015-02-12 4 WENDER JOSEPH H By Trust ISIS Common Stock S - Sale I 62.1460 -10,000 -621 37,217
2015-02-17 2015-02-12 4 WENDER JOSEPH H By Trust ISIS Common Stock M - Exercise I 3.9500 10,000 40 47,217
2015-02-13 2015-02-11 4 KLEIN JOSEPH III ISIS Common Stock G - Gift D -2,000 1,095
2015-02-05 2015-02-03 4 LOSCALZO JOSEPH ISIS Restricted Stock Units M - Exercise D -938 2,812
2015-02-05 2015-02-03 4 LOSCALZO JOSEPH ISIS Common Stock M - Exercise D 938 938
2015-01-29 2015-01-27 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,000 11,350
2015-01-29 2015-01-27 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,000 69,163
2015-01-29 2015-01-27 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 72.9260 -1,000 -73 1,297
2015-01-29 2015-01-27 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 1,000 9 2,297
2015-01-29 2015-01-27 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 72.9260 -10,000 -729 14,642
2015-01-29 2015-01-27 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 10,000 113 24,642
2015-01-20 2015-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 67.9640 -714 -49 6,174
2015-01-20 2015-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 67.9640 -250 -17 5,013
2015-01-20 2015-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 67.9640 -120 -8 4,609
2015-01-20 2015-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 67.9640 -207 -14 4,416
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -1,875 5,625
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -654 1,307
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -313 624
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -541 541
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units A - Award D 5,242 5,242
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 1,875 6,888
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 654 5,263
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 313 4,729
2015-01-20 2015-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 541 4,623
2015-01-20 2015-01-16 4 Geary Richard S ISIS Common Stock S - Sale D 67.9640 -714 -49 7,570
2015-01-20 2015-01-16 4 Geary Richard S ISIS Common Stock S - Sale D 67.9640 -533 -36 6,409
2015-01-20 2015-01-16 4 Geary Richard S ISIS Common Stock S - Sale D 67.9640 -296 -20 5,544
2015-01-20 2015-01-15 4 Geary Richard S ISIS Restricted Stock Units M - Exercise D -1,875 5,625
2015-01-20 2015-01-15 4 Geary Richard S ISIS Restricted Stock Units M - Exercise D -1,398 2,794
2015-01-20 2015-01-15 4 Geary Richard S ISIS Restricted Stock Units M - Exercise D -776 775
2015-01-20 2015-01-15 4 Geary Richard S ISIS Restricted Stock Units A - Award D 5,518 5,518
2015-01-20 2015-01-15 4 Geary Richard S ISIS Common Stock M - Exercise D 1,875 8,284
2015-01-20 2015-01-15 4 Geary Richard S ISIS Common Stock M - Exercise D 1,398 6,942
2015-01-20 2015-01-15 4 Geary Richard S ISIS Common Stock M - Exercise D 776 5,840
2015-01-20 2015-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 67.9640 -714 -49 4,426
2015-01-20 2015-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 67.9640 -539 -37 3,265
2015-01-20 2015-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 67.9640 -80 -5 2,389
2015-01-20 2015-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 67.9640 -201 -14 2,261
2015-01-20 2015-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -1,875 5,625
2015-01-20 2015-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -1,415 2,830
2015-01-20 2015-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -208 208
2015-01-20 2015-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -527 527
2015-01-20 2015-01-15 4 Monia Brett P ISIS Restricted Stock Units A - Award D 6,070 6,070
2015-01-20 2015-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 1,875 5,140
2015-01-20 2015-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 1,415 3,804
2015-01-20 2015-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 208 2,469
2015-01-20 2015-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 527 2,462
2015-01-20 2015-01-16 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 67.9640 -136 -9 1,297
2015-01-20 2015-01-16 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 67.9640 -160 -11 1,079
2015-01-20 2015-01-16 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 67.9640 -121 -8 822
2015-01-20 2015-01-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 67.9645 -4,130 -281 14,642
2015-01-20 2015-01-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 67.9640 -2,933 -199 10,959
2015-01-20 2015-01-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 67.9640 -1,574 -107 8,344
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Restricted Stock Units M - Exercise I -354 1,062
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Restricted Stock Units M - Exercise I -417 832
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Restricted Stock Units M - Exercise I -316 316
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units M - Exercise D -7,813 23,437
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units M - Exercise D -5,548 11,094
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units M - Exercise D -2,977 2,977
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Restricted Stock Units A - Award I 1,450 1,450
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units A - Award D 27,500 27,500
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 354 1,433
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 417 1,239
2015-01-20 2015-01-15 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 316 943
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 7,813 18,772
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5,548 13,892
2015-01-20 2015-01-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 2,977 9,918
2015-01-20 2015-01-15 4 Boyce Sarah ISIS Restricted Stock Units A - Award D 8,750 8,750
2015-01-20 2015-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 67.9640 -714 -49 3,387
2015-01-20 2015-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 67.9640 -250 -17 2,226
2015-01-20 2015-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 67.9640 -120 -8 1,822
2015-01-20 2015-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 67.9640 -207 -14 1,629
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -1,875 5,625
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -654 1,307
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -313 624
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -541 541
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units A - Award D 5,518 5,518
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 1,875 4,101
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 654 2,476
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 313 1,942
2015-01-20 2015-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 541 1,836
2015-01-20 2015-01-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 67.9640 -714 -49 7,229
2015-01-20 2015-01-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 67.9640 -539 -37 6,068
2015-01-20 2015-01-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 67.9640 -265 -18 5,192
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units M - Exercise D -1,875 5,625
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units M - Exercise D -1,415 2,830
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units M - Exercise D -694 694
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units A - Award D 5,242 5,242
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 1,875 7,943
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 1,415 6,607
2015-01-20 2015-01-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 694 5,457
2015-01-20 2015-01-16 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 67.9640 -1,818 -124 8,072
2015-01-20 2015-01-16 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 67.9640 -1,372 -93 6,452
2015-01-20 2015-01-16 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 67.9640 -903 -61 5,229
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units M - Exercise D -3,438 10,312
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units M - Exercise D -2,595 5,190
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units M - Exercise D -1,715 1,715
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units A - Award D 22,076 22,076
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 3,438 9,890
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 2,595 7,824
2015-01-20 2015-01-15 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 1,715 6,132
2015-01-13 2015-01-12 4 Geary Richard S ISIS Common Stock S - Sale D 73.1000 -597 -44 5,064
2015-01-13 2015-01-09 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,000 12,350
2015-01-13 2015-01-09 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,000 79,163
2015-01-13 2015-01-09 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 73.5700 -1,000 -74 627
2015-01-13 2015-01-09 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 1,000 9 1,627
2015-01-13 2015-01-09 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 73.5700 -10,000 -736 6,941
2015-01-13 2015-01-09 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 10,000 113 16,941
2015-01-08 2015-01-07 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,000 13,350
2015-01-08 2015-01-07 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,000 89,163
2015-01-08 2015-01-07 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 68.0480 -1,000 -68 627
2015-01-08 2015-01-07 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 1,000 9 1,627
2015-01-08 2015-01-07 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 68.0480 -10,000 -680 6,941
2015-01-08 2015-01-07 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 10,000 113 16,941
2015-01-08 2015-01-06 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,000 14,350
2015-01-08 2015-01-06 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,000 99,163
2015-01-08 2015-01-06 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 66.0380 -1,000 -66 627
2015-01-08 2015-01-06 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 1,000 9 1,627
2015-01-08 2015-01-06 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 66.0380 -10,000 -660 6,941
2015-01-08 2015-01-06 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 10,000 113 16,941
2015-01-05 3 Boyce Sarah ISIS No Securities Owned D 0
2015-01-05 2015-01-02 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 61.57 8,700 8,700
2015-01-05 2015-01-02 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) A - Award D 61.57 165,000 165,000
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -283 9,750
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,217 13,353
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) A - Award D 61.57 31,457 31,457
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 62.1150 -283 -18 4,082
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 283 2 4,365
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 62.1150 -1,217 -76 4,082
2015-01-05 2015-01-02 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.8200 1,217 13 5,299
2015-01-05 2015-01-01 4 O'NEIL PATRICK R. ISIS Common Stock J - Other D 30.0475 329 10 4,082
2015-01-05 2015-01-02 4 Monia Brett P ISIS Employee Stock Option (right to buy) A - Award D 61.57 36,423 36,423
2015-01-05 2015-01-02 4 Monia Brett P ISIS Common Stock S - Sale D 62.7500 -76 -5 1,935
2015-01-05 2015-01-01 4 Monia Brett P ISIS Common Stock J - Other D 30.0475 198 6 2,011
2015-01-05 2015-01-02 4 Geary Richard S ISIS Employee Stock Option (right to buy) A - Award D 61.57 33,112 33,112
2015-01-05 2015-01-01 4 Geary Richard S ISIS Common Stock J - Other D 30.0475 273 8 5,661
2015-01-05 2015-01-01 4 Boyce Sarah ISIS Employee Stock Option (right to buy) A - Award D 61.74 52,500 52,500
2015-01-05 2015-01-02 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) A - Award D 61.57 33,112 33,112
2015-01-05 2015-01-01 4 HOUGEN ELIZABETH L ISIS Common Stock J - Other D 30.0475 63 2 1,295
2015-01-05 2015-01-02 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -11,200 48,570
2015-01-05 2015-01-02 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) A - Award D 61.57 132,458 132,458
2015-01-05 2015-01-02 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 62.1150 -11,200 -696 4,417
2015-01-05 2015-01-02 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 11,200 165 15,617
2015-01-05 2015-01-01 4 PARSHALL B LYNNE ISIS Common Stock J - Other D 30.0475 111 3 4,417
2015-01-05 2015-01-02 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) A - Award D 61.57 31,457 31,457
2015-01-05 2015-01-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 30.0475 136 4 4,763
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -1,500 10,033
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 50.3700 -500 -25 3,753
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 500 4 4,253
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 500 4 4,253
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 500 4 4,253
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 51.0500 -500 -26 3,753
2014-12-03 2014-12-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 52.2100 -500 -26 3,753
2014-11-05 2014-11-03 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -1,500 11,533
2014-11-05 2014-11-03 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 46.1700 -1,500 -69 3,753
2014-11-05 2014-11-03 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 1,500 11 5,253
2014-10-31 2014-10-30 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -8,561 21,870
2014-10-31 2014-10-30 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -2,510 59,770
2014-10-31 2014-10-30 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 45.1210 -8,561 -386 4,306
2014-10-31 2014-10-30 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 7.2500 8,561 62 12,867
2014-10-31 2014-10-30 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 45.1210 -2,510 -113 4,306
2014-10-31 2014-10-30 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.6900 2,510 37 6,816
2014-10-24 2014-10-23 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,600 15,350
2014-10-24 2014-10-23 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,000 109,163
2014-10-24 2014-10-23 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -3,000 0
2014-10-24 2014-10-23 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 42.2200 -1,600 -68 627
2014-10-24 2014-10-23 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 9.2200 1,600 15 2,227
2014-10-24 2014-10-23 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 42.2200 -10,000 -422 6,941
2014-10-24 2014-10-23 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.2700 10,000 113 16,941
2014-10-24 2014-10-23 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 42.2200 -3,000 -127 6,941
2014-10-24 2014-10-23 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 3,000 43 9,941
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -1,267 13,033
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -233 5,750
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 37.9000 -800 -30 3,753
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 800 6 4,553
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 38.2000 -467 -18 3,753
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 467 3 4,220
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 38.2000 -233 -9 3,753
2014-10-03 2014-10-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 233 2 3,986
2014-10-03 2014-10-03 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -1,000 16,950
2014-10-03 2014-10-03 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -13,000 3,000
2014-10-03 2014-10-03 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 39.4870 -1,000 -39 627
2014-10-03 2014-10-03 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 9.2200 1,000 9 1,627
2014-10-03 2014-10-03 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 39.4870 -13,000 -513 6,941
2014-10-03 2014-10-03 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 13,000 188 19,941
2014-10-03 2014-10-01 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 9.22 -800 17,950
2014-10-03 2014-10-01 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 11.27 -1,200 1,000
2014-10-03 2014-10-01 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -20,000 16,000
2014-10-03 2014-10-01 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 37.9110 -800 -30 627
2014-10-03 2014-10-01 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 9.2200 800 7 1,427
2014-10-03 2014-10-01 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 37.9110 -1,200 -45 627
2014-10-03 2014-10-01 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 11.2700 1,200 14 1,827
2014-10-03 2014-10-01 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 37.9110 -20,000 -758 6,941
2014-10-03 2014-10-01 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 20,000 289 26,941
2014-09-04 2014-09-02 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -443 30,431
2014-09-04 2014-09-02 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,628 7,593
2014-09-04 2014-09-02 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.2409 -443 -18 4,306
2014-09-04 2014-09-02 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 7.2500 443 3 4,749
2014-09-04 2014-09-02 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.2409 -10,628 -428 4,306
2014-09-04 2014-09-02 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 10.2900 10,628 109 14,934
2014-09-04 2014-09-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -1,500 5,983
2014-09-04 2014-09-02 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 40.6000 -700 -28 3,753
2014-09-04 2014-09-02 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 700 7 4,453
2014-09-04 2014-09-02 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 40.3000 -800 -32 3,753
2014-09-04 2014-09-02 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 800 8 4,553
2014-08-28 2014-08-26 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -10,000 2,266
2014-08-28 2014-08-26 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -15,000 5,245
2014-08-28 2014-08-26 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,344 0
2014-08-28 2014-08-26 4 Monia Brett P ISIS Common Stock S - Sale D 38.1440 -10,000 -381 1,813
2014-08-28 2014-08-26 4 Monia Brett P ISIS Common Stock M - Exercise D 7.2500 10,000 72 11,813
2014-08-28 2014-08-26 4 Monia Brett P ISIS Common Stock S - Sale D 38.1440 -15,000 -572 1,813
2014-08-28 2014-08-26 4 Monia Brett P ISIS Common Stock M - Exercise D 10.2900 15,000 154 16,813
2014-08-28 2014-08-26 4 Monia Brett P ISIS Common Stock S - Sale D 38.1440 -2,344 -89 1,813
2014-08-28 2014-08-26 4 Monia Brett P ISIS Common Stock M - Exercise D 11.2700 2,344 26 4,157
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -5,000 0
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Common Stock S - Sale D 40.5500 -2,000 -81 4,627
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 2,000 31 6,627
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 2,000 31 6,627
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Common Stock S - Sale D 40.5300 -1,000 -41 4,627
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 1,000 15 5,627
2014-08-28 2014-08-27 4 BENNETT C FRANK ISIS Common Stock S - Sale D 40.5000 -2,000 -81 4,627
2014-08-15 2014-08-13 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 11.27 -1,600 2,200
2014-08-15 2014-08-13 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -15,500 36,000
2014-08-15 2014-08-13 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 35.4540 -1,600 -57 627
2014-08-15 2014-08-13 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 11.2700 1,600 18 2,227
2014-08-15 2014-08-13 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 35.4540 -15,500 -550 6,941
2014-08-15 2014-08-13 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 15,500 224 22,441
2014-08-12 2014-08-12 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -800 7,483
2014-08-12 2014-08-12 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.0000 -800 -28 3,753
2014-08-12 2014-08-12 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 800 8 4,553
2014-08-12 2014-08-11 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -700 8,983
2014-08-12 2014-08-11 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.0000 -700 -24 3,753
2014-08-12 2014-08-11 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 700 7 4,453
2014-08-01 2014-07-31 4 Monia Brett P ISIS Common Stock S - Sale D 31.5000 -79 -2 1,813
2014-08-01 2014-08-01 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 11.27 -1,000 3,800
2014-08-01 2014-08-01 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -15,000 51,500
2014-08-01 2014-08-01 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 30.5250 -1,000 -31 627
2014-08-01 2014-08-01 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 11.2700 1,000 11 1,627
2014-08-01 2014-08-01 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.5250 -15,000 -458 6,941
2014-08-01 2014-08-01 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 15,000 217 21,941
2014-07-02 2014-07-02 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units M - Exercise D -313 624
2014-07-02 2014-07-02 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 313 50,395
2014-07-02 2014-07-01 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) A - Award D 35.53 16,000 16,000
2014-07-02 2014-07-01 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units A - Award D 2,667 2,667
2014-07-02 2014-07-01 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units M - Exercise D -469 1,406
2014-07-02 2014-07-01 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 469 50,082
2014-07-02 2014-07-02 4 KLEIN JOSEPH III ISIS Restricted Stock Units M - Exercise D -313 624
2014-07-02 2014-07-02 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 313 3,095
2014-07-02 2014-07-01 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) A - Award D 35.53 16,000 16,000
2014-07-02 2014-07-01 4 KLEIN JOSEPH III ISIS Restricted Stock Units A - Award D 2,667 2,667
2014-07-02 2014-07-01 4 KLEIN JOSEPH III ISIS Restricted Stock Units M - Exercise D -469 1,406
2014-07-02 2014-07-01 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 469 2,782
2014-07-02 2014-07-01 4 LOSCALZO JOSEPH ISIS Director Stock Option (right to buy) A - Award D 35.53 16,000 16,000
2014-07-02 2014-07-01 4 LOSCALZO JOSEPH ISIS Restricted Stock Units A - Award D 2,667 2,667
2014-07-02 2014-07-02 4 MUTO FREDERICK T ISIS Restricted Stock Units M - Exercise D -313 624
2014-07-02 2014-07-02 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 313 1,095
2014-07-02 2014-07-01 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) A - Award D 35.53 16,000 16,000
2014-07-02 2014-07-01 4 MUTO FREDERICK T ISIS Restricted Stock Units A - Award D 2,667 2,667
2014-07-02 2014-07-01 4 MUTO FREDERICK T ISIS Restricted Stock Units M - Exercise D -469 1,406
2014-07-02 2014-07-01 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 469 782
2014-07-02 2014-07-02 4 WENDER JOSEPH H ISIS Restricted Stock Units M - Exercise D -313 624
2014-07-02 2014-07-02 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 313 37,217
2014-07-02 2014-07-01 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) A - Award D 35.53 16,000 16,000
2014-07-02 2014-07-01 4 WENDER JOSEPH H ISIS Restricted Stock Units A - Award D 2,667 2,667
2014-07-02 2014-07-01 4 WENDER JOSEPH H ISIS Restricted Stock Units M - Exercise D -469 1,406
2014-07-02 2014-07-01 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 469 36,904
2014-07-02 2014-07-01 4 Castleman Breaux ISIS Director Stock Option (right to buy) A - Award D 35.53 16,000 16,000
2014-07-02 2014-07-01 4 Castleman Breaux ISIS Restricted Stock Units A - Award D 2,667 2,667
2014-07-02 2014-07-01 4 Castleman Breaux ISIS Restricted Stock Units M - Exercise D -938 2,812
2014-07-02 2014-07-01 4 Castleman Breaux ISIS Restricted Stock Units M - Exercise D -469 1,406
2014-07-02 2014-07-01 4 Castleman Breaux ISIS Common Stock M - Exercise D 938 1,407
2014-07-02 2014-07-01 4 Castleman Breaux ISIS Common Stock M - Exercise D 469 469
2014-07-02 2014-07-02 4 Geary Richard S ISIS Common Stock S - Sale D 35.9500 -164 -6 5,388
2014-07-02 2014-07-01 4 Geary Richard S ISIS Common Stock J - Other D 30.2005 597 18 5,552
2014-07-02 2014-07-01 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -1,500 8,983
2014-07-02 2014-07-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.3333 -1,500 -53 3,753
2014-07-02 2014-07-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 1,500 15 5,253
2014-07-02 2014-07-01 4 O'NEIL PATRICK R. ISIS Common Stock J - Other D 30.2005 403 12 3,753
2014-07-02 2014-07-01 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 11.27 -1,800 4,800
2014-07-02 2014-07-01 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 14.47 -200 0
2014-07-02 2014-07-01 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 15,500 66,500
2014-07-02 2014-07-01 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 35.5500 -1,800 -64 627
2014-07-02 2014-07-01 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 11.2700 1,800 20 2,427
2014-07-02 2014-07-01 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 35.5500 -200 -7 627
2014-07-02 2014-07-01 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 14.4700 200 3 827
2014-07-02 2014-07-01 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 35.5780 -15,500 -551 6,941
2014-07-02 2014-07-01 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 15,500 224 22,441
2014-07-01 2014-07-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 30.2005 291 9 4,627
2014-07-01 2014-07-01 4 Monia Brett P ISIS Common Stock J - Other D 30.2005 76 2 1,892
2014-07-01 2014-07-01 4 PARSHALL B LYNNE ISIS Common Stock J - Other D 30.2005 284 9 4,306
2014-06-25 2014-06-23 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -11,200 5,000
2014-06-25 2014-06-23 4 BENNETT C FRANK ISIS Common Stock S - Sale D 36.5430 -5,000 -183 4,336
2014-06-25 2014-06-23 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 5,000 77 9,336
2014-06-25 2014-06-23 4 BENNETT C FRANK ISIS Common Stock S - Sale D 36.9670 -6,200 -229 4,336
2014-06-25 2014-06-23 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 6,200 95 10,536
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -667 10,483
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 8.00 -33 1,667
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2700 -67 -2 3,350
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 67 1 3,417
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2750 -100 -4 3,350
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 100 1 3,450
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2900 -200 -7 3,350
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 200 2 3,550
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.4500 -300 -11 3,350
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 300 3 3,650
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2700 -33 -1 3,350
2014-06-20 2014-06-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 33 0 3,383
2014-06-20 2014-06-19 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -11,000 82,000
2014-06-20 2014-06-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 35.1010 -11,000 -386 6,941
2014-06-20 2014-06-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 11,000 159 17,941
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 8.00 -800 1,700
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2700 -100 -4 3,350
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 100 1 3,450
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 100 1 3,450
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2525 -100 -4 3,350
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.0200 -400 -14 3,350
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 400 3 3,750
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 35.2500 -200 -7 3,350
2014-06-18 2014-06-16 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 200 2 3,550
2014-06-12 2014-06-10 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 14.47 -1,000 200
2014-06-12 2014-06-10 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -10,000 93,000
2014-06-12 2014-06-10 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 33.4550 -1,000 -33 627
2014-06-12 2014-06-10 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 14.4700 1,000 14 1,627
2014-06-12 2014-06-10 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 33.4550 -10,000 -335 6,941
2014-06-12 2014-06-10 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 10,000 145 16,941
2014-06-03 2014-06-02 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) M - Exercise D 5.72 -10,000 0
2014-06-03 2014-06-02 4 MUTO FREDERICK T ISIS Common Stock S - Sale D 28.5900 -10,000 -286 313
2014-06-03 2014-06-02 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 5.7200 10,000 57 10,313
2014-04-17 2014-04-17 4 BERTHELSEN SPENCER R ISIS Employee Stock Option (right to buy) M - Exercise D 5.72 -10,000 0
2014-04-17 2014-04-17 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 5.7200 10,000 57 49,613
2014-04-04 2014-04-02 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 14.47 -1,800 1,200
2014-04-04 2014-04-02 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -7,000 103,000
2014-04-04 2014-04-02 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 43.6480 -1,800 -79 627
2014-04-04 2014-04-02 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 14.4700 1,800 26 2,427
2014-04-04 2014-04-02 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 43.6480 -7,000 -306 6,941
2014-04-04 2014-04-02 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 7,000 101 13,941
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 8.00 -1,500 1,458
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 44.0200 -500 -22 3,350
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 500 4 3,850
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 500 4 3,850
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 500 4 3,850
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 44.3000 -500 -22 3,350
2014-04-03 2014-04-01 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 44.8800 -500 -22 3,350
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.82 -1,130 14,570
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -370 0
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 50.7000 -800 -41 3,350
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.8200 800 9 4,150
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 49.2000 -330 -16 3,350
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.8200 330 4 3,680
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 49.2000 -370 -18 3,350
2014-03-05 2014-03-03 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 370 4 3,720
2014-02-07 2014-02-06 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 5.72 -5,300 0
2014-02-07 2014-02-06 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 5.7200 5,300 30 36,435
2014-02-05 3 LOSCALZO JOSEPH ISIS No Securities Owned D 0
2014-02-05 2014-02-03 4 LOSCALZO JOSEPH ISIS Restricted Stock Units A - Award D 3,750 3,750
2014-02-05 2014-02-03 4 LOSCALZO JOSEPH ISIS Director Stock Option (right to buy) A - Award D 49.09 22,500 22,500
2014-02-05 2014-02-03 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 5.72 -4,700 5,300
2014-02-05 2014-02-03 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 48.7825 -4,700 -229 31,135
2014-02-05 2014-02-03 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 5.7200 4,700 27 35,835
2014-02-05 2014-02-03 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -1,500 370
2014-02-05 2014-02-03 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 50.4510 -1,500 -76 3,350
2014-02-05 2014-02-03 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 1,500 17 4,850
2014-01-31 2014-01-30 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -15,875 30,874
2014-01-31 2014-01-30 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -23,635 18,221
2014-01-31 2014-01-30 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 50.3640 -15,875 -800 4,022
2014-01-31 2014-01-30 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 7.2500 15,875 115 19,897
2014-01-31 2014-01-30 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 50.3640 -23,635 -1,190 4,022
2014-01-31 2014-01-30 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 10.2900 23,635 243 27,657
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 7.25 -5,000 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By son-in-law ISIS Employee Stock Option (right to buy) M - Exercise I 7.25 -5,000 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 7.25 -5,000 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -31,028 41,856
2014-01-31 2014-01-29 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -3,972 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 48.8070 -5,000 -244 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By son-in-law ISIS Common Stock S - Sale I 48.8070 -5,000 -244 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 7.2500 5,000 36 5,000
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 7.2500 5,000 36 5,000
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By son-in-law ISIS Common Stock M - Exercise I 7.2500 5,000 36 5,000
2014-01-31 2014-01-29 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 48.8070 -5,000 -244 0
2014-01-31 2014-01-29 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 48.8070 -31,028 -1,514 4,022
2014-01-31 2014-01-29 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 10.2900 31,028 319 35,050
2014-01-31 2014-01-29 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 48.8070 -3,972 -194 4,022
2014-01-31 2014-01-29 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.2700 3,972 45 7,994
2014-01-24 2014-01-22 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 50.9803 -10,000 -510 31,135
2014-01-24 2014-01-22 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -13,900 14,035
2014-01-24 2014-01-22 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 14.69 -8,300 25,240
2014-01-24 2014-01-22 4 Geary Richard S ISIS Common Stock S - Sale D 50.0460 -13,900 -696 4,955
2014-01-24 2014-01-22 4 Geary Richard S ISIS Common Stock M - Exercise D 7.2500 13,900 101 18,855
2014-01-24 2014-01-22 4 Geary Richard S ISIS Common Stock S - Sale D 50.0460 -8,300 -415 4,955
2014-01-24 2014-01-22 4 Geary Richard S ISIS Common Stock M - Exercise D 14.6900 8,300 122 13,255
2014-01-24 2014-01-22 4 PARSHALL B LYNNE By son-in-law ISIS Employee Stock Option (right to buy) G - Gift I 7.25 5,000 5,000
2014-01-24 2014-01-22 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) G - Gift D 7.25 -5,000 46,749
2014-01-24 2014-01-24 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 12.94 -2,813 8,437
2014-01-24 2014-01-24 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 16.32 -7,500 0
2014-01-24 2014-01-24 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 48.6102 -2,813 -137 2,313
2014-01-24 2014-01-24 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 12.9400 2,813 36 5,126
2014-01-24 2014-01-24 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 48.6797 -7,500 -365 2,313
2014-01-24 2014-01-24 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 16.3200 7,500 122 9,813
2014-01-17 2014-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 47.0812 -120 -6 3,350
2014-01-17 2014-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 47.0810 -207 -10 3,157
2014-01-17 2014-01-16 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 47.0812 -250 -12 2,822
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -313 937
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -542 1,082
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -654 1,961
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units A - Award D 7,500 7,500
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 313 3,470
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 542 3,364
2014-01-17 2014-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 654 3,072
2014-01-17 2014-01-16 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 47.0826 -988 -47 4,022
2014-01-17 2014-01-16 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 47.0823 -653 -31 2,415
2014-01-17 2014-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units M - Exercise D -2,595 7,785
2014-01-17 2014-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units M - Exercise D -1,715 3,430
2014-01-17 2014-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units A - Award D 13,750 13,750
2014-01-17 2014-01-15 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 2,595 5,010
2014-01-17 2014-01-15 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 1,715 3,068
2014-01-17 2014-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 47.0801 -202 -10 1,816
2014-01-17 2014-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 47.0807 -80 -4 1,490
2014-01-17 2014-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 47.0800 -539 -25 1,362
2014-01-17 2014-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -528 1,054
2014-01-17 2014-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -208 416
2014-01-17 2014-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -1,415 4,245
2014-01-17 2014-01-15 4 Monia Brett P ISIS Restricted Stock Units A - Award D 7,500 7,500
2014-01-17 2014-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 528 2,018
2014-01-17 2014-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 208 1,570
2014-01-17 2014-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 1,415 1,901
2014-01-17 2014-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 47.0796 -120 -6 1,232
2014-01-17 2014-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 47.0801 -207 -10 1,039
2014-01-17 2014-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 47.0797 -250 -12 704
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -313 937
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -542 1,082
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -654 1,961
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units A - Award D 7,500 7,500
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 313 1,352
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 542 1,246
2014-01-17 2014-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 654 954
2014-01-17 2014-01-16 4 Geary Richard S ISIS Common Stock S - Sale D 47.0813 -533 -25 4,955
2014-01-17 2014-01-16 4 Geary Richard S ISIS Common Stock S - Sale D 47.0813 -296 -14 4,090
2014-01-17 2014-01-15 4 Geary Richard S ISIS Restricted Stock Units M - Exercise D -1,398 4,192
2014-01-17 2014-01-15 4 Geary Richard S ISIS Restricted Stock Units M - Exercise D -776 1,551
2014-01-17 2014-01-15 4 Geary Richard S ISIS Restricted Stock Units A - Award D 7,500 7,500
2014-01-17 2014-01-15 4 Geary Richard S ISIS Common Stock M - Exercise D 1,398 5,488
2014-01-17 2014-01-15 4 Geary Richard S ISIS Common Stock M - Exercise D 776 4,386
2014-01-17 2014-01-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 47.0810 -265 -12 4,336
2014-01-17 2014-01-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 47.0811 -539 -25 3,906
2014-01-17 2014-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units M - Exercise D -695 1,388
2014-01-17 2014-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units M - Exercise D -1,415 4,245
2014-01-17 2014-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units A - Award D 7,500 7,500
2014-01-17 2014-01-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 695 4,601
2014-01-17 2014-01-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 1,415 4,445
2014-01-17 2014-01-16 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 47.0807 -121 -6 627
2014-01-17 2014-01-16 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 47.0799 -160 -8 431
2014-01-17 2014-01-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 47.0811 -1,134 -53 6,941
2014-01-17 2014-01-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 47.0812 -2,112 -99 5,097
2014-01-17 2014-01-15 4 CROOKE STANLEY T By Wife ISIS Restricted StockUnits M - Exercise I -317 632
2014-01-17 2014-01-15 4 CROOKE STANLEY T By Wife ISIS Restricted Stock Units M - Exercise I -417 1,249
2014-01-17 2014-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units M - Exercise D -2,978 5,954
2014-01-17 2014-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units M - Exercise D -5,548 16,642
2014-01-17 2014-01-15 4 CROOKE STANLEY T By Wife ISIS Restricted Stock Units A - Award I 1,416 1,416
2014-01-17 2014-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units A - Award D 31,250 31,250
2014-01-17 2014-01-15 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 317 748
2014-01-17 2014-01-15 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 417 591
2014-01-17 2014-01-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 2,978 8,075
2014-01-17 2014-01-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5,548 7,209
2014-01-10 2014-01-08 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 14.47 -1,500 3,000
2014-01-10 2014-01-08 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -11,000 110,000
2014-01-10 2014-01-08 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 40.0520 -1,500 -60 174
2014-01-10 2014-01-08 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 14.4700 1,500 22 1,674
2014-01-10 2014-01-08 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 40.0520 -11,000 -441 1,661
2014-01-10 2014-01-08 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 11,000 159 12,661
2014-01-08 2014-01-08 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -7,600 8,426
2014-01-08 2014-01-08 4 Geary Richard S ISIS Common Stock S - Sale D 42.0200 -7,600 -319 3,610
2014-01-08 2014-01-08 4 Geary Richard S ISIS Common Stock M - Exercise D 10.2900 7,600 78 11,210
2014-01-08 2014-01-06 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -7,400 80
2014-01-08 2014-01-06 4 Geary Richard S ISIS Common Stock S - Sale D 38.8330 -7,400 -287 3,610
2014-01-08 2014-01-06 4 Geary Richard S ISIS Common Stock M - Exercise D 11.2700 7,400 83 11,010
2014-01-03 2014-01-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) A - Award D 39.87 45,000 45,000
2014-01-03 2014-01-01 4 O'NEIL PATRICK R. ISIS Common Stock J - Other D 24.1995 395 10 2,418
2014-01-03 2014-01-02 4 Monia Brett P ISIS Employee Stock Option (right to buy) A - Award D 39.87 45,000 45,000
2014-01-03 2014-01-02 4 Monia Brett P ISIS Common Stock S - Sale D 39.2530 -362 -14 486
2014-01-03 2014-01-01 4 Monia Brett P ISIS Common Stock J - Other D 24.1995 79 2 848
2014-01-03 2014-01-02 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) A - Award D 39.87 82,500 82,500
2014-01-03 2014-01-01 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 7.25 5,000 5,000
2014-01-03 2014-01-01 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 7.25 5,000 5,000
2014-01-03 2014-01-01 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) G - Gift D 7.25 -10,000 51,749
2014-01-03 2014-01-01 4 PARSHALL B LYNNE ISIS Common Stock J - Other D 24.1995 397 10 1,353
2014-01-03 2014-01-02 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) A - Award D 39.87 45,000 45,000
2014-01-03 2014-01-02 4 Geary Richard S ISIS Employee Stock Option (right to buy) A - Award D 39.87 45,000 45,000
2014-01-03 2014-01-01 4 Geary Richard S ISIS Common Stock J - Other D 24.1995 164 4 3,610
2014-01-03 2014-01-02 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) A - Award I 39.87 8,500 8,500
2014-01-03 2014-01-02 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) A - Award D 39.87 187,500 187,500
2014-01-03 2014-01-02 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 39.2530 -2,500 -98 174
2014-01-03 2014-01-02 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 14.4700 2,500 36 2,674
2014-01-03 2014-01-02 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 40.0000 -4,000 -160 1,661
2014-01-03 2014-01-02 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 4,000 58 5,661
2014-01-03 2014-01-02 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 39.2530 -25,000 -981 1,661
2014-01-03 2014-01-02 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 14.4700 25,000 362 26,661
2014-01-03 2014-01-02 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) A - Award D 39.87 45,000 45,000
2014-01-03 2014-01-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 24.1995 164 4 3,030
2013-12-30 2013-12-26 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -37,811 3,972
2013-12-30 2013-12-26 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.9080 -37,811 -1,547 956
2013-12-30 2013-12-26 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.2700 37,811 426 38,767
2013-12-24 2013-12-24 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -20,000 41,783
2013-12-24 2013-12-24 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 40.9960 -20,000 -820 956
2013-12-24 2013-12-24 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.2700 20,000 225 20,956
2013-12-24 2013-12-23 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -1,771 61,783
2013-12-24 2013-12-23 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -48,229 0
2013-12-24 2013-12-23 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 41.6810 -1,771 -74 956
2013-12-24 2013-12-23 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.2700 1,771 20 2,727
2013-12-24 2013-12-23 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 41.6810 -48,229 -2,010 956
2013-12-24 2013-12-23 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.4700 48,229 698 49,185
2013-12-20 2013-12-20 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 40.0125 -10,000 -400 41,135
2013-12-20 2013-12-19 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 16.32 -15,000 0
2013-12-20 2013-12-19 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 39.1340 -9,731 -381 51,135
2013-12-20 2013-12-19 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 16.3200 15,000 245 60,866
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -10,000 16,200
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Common Stock S - Sale D 39.9000 -4,550 -182 2,866
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 4,550 70 7,416
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Common Stock S - Sale D 39.9400 -3,640 -145 2,866
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 3,640 56 6,506
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Common Stock S - Sale D 39.9200 -1,810 -72 2,866
2013-12-06 2013-12-05 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 1,810 28 4,676
2013-11-27 2013-11-25 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 36.8594 -6,000 -221 2,313
2013-11-27 2013-11-26 4 WENDER JOSEPH H ISIS Common Stock S - Sale D 36.6336 -10,000 -366 45,866
2013-09-23 2013-09-19 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -10,000 26,200
2013-09-23 2013-09-19 4 BENNETT C FRANK ISIS Common Stock S - Sale D 35.0200 -10,000 -350 2,866
2013-09-23 2013-09-19 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 10,000 154 12,866
2013-09-23 2013-09-20 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -18,281 2,344
2013-09-23 2013-09-20 4 Monia Brett P ISIS Common Stock S - Sale D 35.8900 -18,281 -656 769
2013-09-23 2013-09-20 4 Monia Brett P ISIS Common Stock M - Exercise D 11.2700 18,281 206 19,050
2013-09-23 2013-09-19 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -1,875 20,625
2013-09-23 2013-09-19 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -22,500 0
2013-09-23 2013-09-19 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 14.65 -5,000 0
2013-09-23 2013-09-19 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 15.75 -625 0
2013-09-23 2013-09-19 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -20,000 0
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock S - Sale D 33.3500 -1,875 -63 769
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock M - Exercise D 11.2700 1,875 21 2,644
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock S - Sale D 33.3500 -22,500 -750 769
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock M - Exercise D 14.4700 22,500 326 23,269
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock S - Sale D 33.3500 -5,000 -167 769
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock M - Exercise D 14.6500 5,000 73 5,769
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock S - Sale D 33.3500 -625 -21 769
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock M - Exercise D 15.7500 625 10 1,394
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock S - Sale D 33.9600 -20,000 -679 769
2013-09-23 2013-09-19 4 Monia Brett P ISIS Common Stock M - Exercise D 15.3800 20,000 308 20,769
2013-09-23 2013-09-20 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -10,000 0
2013-09-23 2013-09-20 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -30,000 48,229
2013-09-23 2013-09-20 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 35.8980 -10,000 -359 956
2013-09-23 2013-09-20 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 15.3800 10,000 154 10,956
2013-09-23 2013-09-20 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 35.8980 -30,000 -1,077 956
2013-09-23 2013-09-20 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 14.4700 30,000 434 30,956
2013-09-23 2013-09-19 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 16.45 -30,000 0
2013-09-23 2013-09-19 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -20,000 10,000
2013-09-23 2013-09-19 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 35.0200 -30,000 -1,051 956
2013-09-23 2013-09-19 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 16.4500 30,000 494 30,956
2013-09-23 2013-09-19 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 35.1240 -20,000 -702 956
2013-09-23 2013-09-19 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 15.3800 20,000 308 20,956
2013-09-23 2013-09-20 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -8,740 0
2013-09-23 2013-09-20 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 35.8980 -8,740 -314 1,661
2013-09-23 2013-09-20 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 8,740 97 10,401
2013-09-23 2013-09-19 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -50,000 8,740
2013-09-23 2013-09-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 35.0200 -30,000 -1,051 1,661
2013-09-23 2013-09-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 30,000 334 31,661
2013-09-23 2013-09-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 35.1240 -20,000 -702 1,661
2013-09-23 2013-09-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 20,000 222 21,661
2013-09-11 2013-09-11 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -1,520 30,000
2013-09-11 2013-09-11 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 31.1810 -1,985 -62 956
2013-09-11 2013-09-11 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 31.1810 -1,520 -47 2,941
2013-09-11 2013-09-11 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 15.3800 1,520 23 4,461
2013-09-11 2013-09-10 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -30,000 31,520
2013-09-11 2013-09-10 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 31.6480 -30,000 -949 2,941
2013-09-11 2013-09-10 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 15.3800 30,000 461 32,941
2013-09-11 2013-09-09 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -30,000 61,520
2013-09-11 2013-09-09 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 30.4150 -30,000 -912 2,941
2013-09-11 2013-09-09 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 15.3800 30,000 461 32,941
2013-09-11 2013-09-09 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -10,000 36,200
2013-09-11 2013-09-09 4 BENNETT C FRANK ISIS Common Stock S - Sale D 30.2250 -10,000 -302 2,866
2013-09-11 2013-09-09 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 15.3800 10,000 154 12,866
2013-09-11 2013-09-11 4 CROOKE STANLEY T By Trust ISIS Common Stock S - Sale I 31.1810 -20,000 -624 725,391
2013-09-11 2013-09-10 4 CROOKE STANLEY T By Trust ISIS Common Stock S - Sale I 31.6480 -30,000 -949 745,391
2013-09-11 2013-09-09 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -26,615 58,740
2013-09-11 2013-09-09 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.4150 -26,615 -809 1,661
2013-09-11 2013-09-09 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 26,615 296 28,276
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.47 -10 0
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.18 -10 0
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,480 1,870
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 26.8500 -10 -0 2,023
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 26.8500 -10 -0 2,023
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.4700 10 0 2,033
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.1800 10 0 2,033
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 26.8500 -637 -17 2,023
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 637 7 2,660
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 27.0000 -526 -14 2,023
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 526 6 2,549
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 27.2500 -1,317 -36 2,023
2013-09-06 2013-09-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 1,317 15 3,340
2013-08-28 3/A Monia Brett P ISIS Common Stock D 2,909
2013-08-28 2013-08-26 4 Monia Brett P ISIS Common Stock S - Sale D 25.5769 -2,909 -74 769
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 9.30 -7,500 7,500
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 9.22 -7,500 7,500
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) M - Exercise D 13.88 -3,750 0
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 28.2200 -7,500 -212 8,313
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 28.2200 -7,500 -212 8,313
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 9.2200 7,500 69 15,813
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 9.3000 7,500 70 15,813
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 28.2200 -3,647 -103 8,313
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 13.8800 3,647 51 11,960
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock S - Sale D 28.2300 -103 -3 8,313
2013-08-13 2013-08-09 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 13.8800 103 1 8,416
2013-07-25 2013-07-23 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -11,500 85,355
2013-07-25 2013-07-23 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0000 -11,500 -345 1,661
2013-07-25 2013-07-23 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 11,500 128 13,161
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -1,885 96,855
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -18,115 0
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 31.0200 -1,885 -58 1,661
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 1,885 21 3,546
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 31.0200 -8,115 -252 1,661
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 8,115 125 9,776
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.5250 -10,000 -305 1,661
2013-07-22 2013-07-22 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 10,000 154 11,661
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -22,200 18,115
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.1850 -10,000 -302 1,661
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 10,000 154 11,661
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 10,000 154 11,661
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.8720 -10,000 -309 1,661
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 31.4000 -2,200 -69 1,661
2013-07-22 2013-07-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 2,200 34 3,861
2013-07-22 2013-07-18 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -20,000 98,740
2013-07-22 2013-07-18 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0220 -10,000 -300 1,661
2013-07-22 2013-07-18 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 10,000 111 11,661
2013-07-22 2013-07-18 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 10,000 111 11,661
2013-07-22 2013-07-18 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.2000 -10,000 -302 1,661
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Emloyee Stock Option (right to buy) M - Exercise I 9.92 -5,000 0
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) M - Exercise I 15.38 -8,300 0
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 31.9600 -5,000 -160 174
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 9.9200 5,000 50 5,174
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 31.9600 -44 -1 174
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 15.3800 44 1 218
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 31.2200 -8,256 -258 174
2013-07-17 2013-07-17 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 15.3800 8,256 127 8,430
2013-07-17 2013-07-16 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -6,000 118,740
2013-07-17 2013-07-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 33.3070 -6,000 -200 1,661
2013-07-17 2013-07-16 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 6,000 67 7,661
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -30,000 124,740
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 33.5650 -10,000 -336 1,661
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 10,000 111 11,661
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 10,000 111 11,661
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 33.8050 -10,000 -338 1,661
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 34.0480 -10,000 -340 1,661
2013-07-17 2013-07-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 10,000 111 11,661
2013-07-12 2013-07-11 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -9,000 0
2013-07-12 2013-07-11 4 Geary Richard S ISIS Common Stock S - Sale D 31.9000 -9,000 -287 3,446
2013-07-12 2013-07-11 4 Geary Richard S ISIS Common Stock M - Exercise D 11.1200 9,000 100 12,446
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -24,000 36,000
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -6,000 40,315
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 33.5008 -12,000 -402 1,661
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 12,000 133 13,661
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 11.1200 12,000 133 13,661
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 33.0840 -12,000 -397 1,661
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 32.8300 -6,000 -197 1,661
2013-07-12 2013-07-12 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 6,000 92 7,661
2013-07-12 2013-07-11 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -30,000 46,315
2013-07-12 2013-07-11 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 32.0030 -30,000 -960 1,661
2013-07-12 2013-07-11 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 30,000 461 311,661
2013-07-12 2013-07-10 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -30,000 76,315
2013-07-12 2013-07-10 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0480 -30,000 -901 1,661
2013-07-12 2013-07-10 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 30,000 461 31,661
2013-07-09 2013-07-09 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -10,358 16,026
2013-07-09 2013-07-09 4 Geary Richard S ISIS Common Stock S - Sale D 30.0430 -10,358 -311 3,446
2013-07-09 2013-07-09 4 Geary Richard S ISIS Common Stock M - Exercise D 10.2900 10,358 107 13,804
2013-07-09 2013-07-08 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -7,060 26,384
2013-07-09 2013-07-08 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -22,940 7,480
2013-07-09 2013-07-08 4 Geary Richard S ISIS Common Stock S - Sale D 30.0900 -7,060 -212 3,446
2013-07-09 2013-07-08 4 Geary Richard S ISIS Common Stock M - Exercise D 10.2900 7,060 73 10,506
2013-07-09 2013-07-08 4 Geary Richard S ISIS Common Stock S - Sale D 30.0900 -17,933 -540 3,446
2013-07-09 2013-07-08 4 Geary Richard S ISIS Common Stock M - Exercise D 11.2700 17,933 202 21,379
2013-07-09 2013-07-08 4 Geary Richard S ISIS Common Stock S - Sale D 30.0260 -5,007 -150 3,446
2013-07-09 2013-07-08 4 Geary Richard S ISIS Common Stock M - Exercise D 11.2700 5,007 56 8,453
2013-07-09 2013-07-05 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 19.08 -5,000 0
2013-07-09 2013-07-05 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,220 30,420
2013-07-09 2013-07-05 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -16,960 0
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock S - Sale D 30.0150 -5,000 -150 3,446
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock M - Exercise D 19.0800 5,000 95 8,446
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock S - Sale D 30.0150 -2,220 -67 3,446
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock M - Exercise D 11.2700 2,220 25 5,666
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock S - Sale D 30.0150 -16,960 -509 3,446
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock M - Exercise D 14.4700 16,960 245 20,406
2013-07-09 2013-07-05 4 Geary Richard S ISIS Common Stock S - Sale D 29.2500 -1,625 -48 3,446
2013-07-09 2013-07-09 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -30,000 106,315
2013-07-09 2013-07-09 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0430 -30,000 -901 1,661
2013-07-09 2013-07-09 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 30,000 461 31,661
2013-07-09 2013-07-08 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -30,000 136,315
2013-07-09 2013-07-08 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0900 -24,992 -752 1,661
2013-07-09 2013-07-08 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 15.3800 24,992 384 26,653
2013-07-09 2013-07-08 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0260 -5,008 -150 1,661
2013-07-09 2013-07-08 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 5,008 77 6,669
2013-07-09 2013-07-05 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -24,180 166,315
2013-07-09 2013-07-05 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 30.0150 -24,180 -726 1,661
2013-07-09 2013-07-05 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 15.3800 24,180 372 25,841
2013-07-05 2013-07-05 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 29.2500 -277 -8 2,023
2013-07-05 2013-07-01 4 O'NEIL PATRICK R. ISIS Common Stock J - Other D 9.1970 976 9 2,300
2013-07-03 2013-07-03 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 19.08 -5,000 5,000
2013-07-03 2013-07-03 4 Geary Richard S ISIS Common Stock S - Sale D 29.0200 -5,000 -145 5,071
2013-07-03 2013-07-03 4 Geary Richard S ISIS Common Stock M - Exercise D 19.0800 5,000 95 10,071
2013-07-03 2013-07-01 4 Geary Richard S ISIS Common Stock J - Other D 9.1970 817 8 5,071
2013-07-03 2013-07-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 9.1970 756 7 2,866
2013-07-03 2013-07-02 4 Monia Brett P ISIS Common Stock S - Sale D 28.6949 -215 -6 5,842
2013-07-03 2013-07-01 4 Monia Brett P ISIS Common Stock J - Other D 9.1970 362 3 6,057
2013-07-03 2013-07-02 4 WENDER JOSEPH H ISIS Restricted Stock Units M - Exercise D -313 937
2013-07-03 2013-07-02 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 313 55,866
2013-07-03 2013-07-01 4 WENDER JOSEPH H ISIS Restricted Stock Units A - Award D 1,875 1,875
2013-07-03 2013-07-01 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) A - Award D 28.47 11,250 11,250
2013-07-03 2013-07-02 4 MUTO FREDERICK T ISIS Restricted Stock Units M - Exercise D -313 937
2013-07-03 2013-07-02 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 313 313
2013-07-03 2013-07-01 4 MUTO FREDERICK T ISIS Restricted Stock Units A - Award D 1,875 1,875
2013-07-03 2013-07-01 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) A - Award D 28.47 11,250 11,250
2013-07-03 2013-07-02 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units M - Exercise D -313 937
2013-07-03 2013-07-02 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 313 39,613
2013-07-03 2013-07-01 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units A - Award D 1,875 1,875
2013-07-03 2013-07-01 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) A - Award D 28.47 11,250 11,250
2013-07-03 2013-07-01 4 Castleman Breaux ISIS Restricted Stock Units A - Award D 1,875 1,875
2013-07-03 2013-07-01 4 Castleman Breaux ISIS Director Stock Option (right to buy) A - Award D 28.47 11,250 11,250
2013-07-03 2013-07-02 4 KLEIN JOSEPH III ISIS Restricted Stock Units M - Exercise D -313 937
2013-07-03 2013-07-02 4 KLEIN JOSEPH III ISIS Common Stock M - Exercise D 313 8,313
2013-07-03 2013-07-01 4 KLEIN JOSEPH III ISIS Restricted Stock Units A - Award D 1,875 1,875
2013-07-03 2013-07-01 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) A - Award D 28.47 11,250 11,250
2013-07-01 2013-07-01 4 CROOKE STANLEY T By Trust ISIS Common Stock S - Sale I 28.1700 -10,000 -282 775,391
2013-07-01 2013-06-28 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 11.12 -5,958 0
2013-07-01 2013-06-28 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 6.81 -4,725 0
2013-07-01 2013-06-28 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -10,000 0
2013-07-01 2013-06-28 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 27.3100 -5,958 -163 174
2013-07-01 2013-06-28 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 11.1200 5,958 66 6,132
2013-07-01 2013-06-28 4 CROOKE STANLEY T By Wife ISIS Common Stock S - Sale I 27.3100 -4,725 -129 174
2013-07-01 2013-06-28 4 CROOKE STANLEY T By Wife ISIS Common Stock M - Exercise I 6.8100 4,725 32 4,899
2013-07-01 2013-06-28 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 27.0700 -10,000 -271 1,661
2013-07-01 2013-06-28 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8100 10,000 68 11,661
2013-07-01 2013-06-27 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -20,000 10,000
2013-07-01 2013-06-27 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 27.4000 -10,000 -274 1,661
2013-07-01 2013-06-27 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8100 10,000 68 11,661
2013-07-01 2013-06-27 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8100 10,000 68 11,661
2013-07-01 2013-06-27 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 28.3000 -10,000 -283 1,661
2013-06-26 3 Castleman Breaux ISIS No securities owned D 0
2013-06-26 2013-06-25 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -12,000 16,960
2013-06-26 2013-06-25 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -4,000 0
2013-06-26 2013-06-25 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -1,049 0
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock S - Sale D 27.8650 -10,435 -291 4,254
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock M - Exercise D 14.4700 10,435 151 14,689
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock S - Sale D 28.3200 -1,565 -44 4,254
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock M - Exercise D 14.4700 1,565 23 5,819
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock S - Sale D 28.3200 -4,000 -113 4,254
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock M - Exercise D 15.3800 4,000 62 8,254
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock S - Sale D 27.5600 -1,049 -29 4,254
2013-06-26 2013-06-25 4 Geary Richard S ISIS Common Stock M - Exercise D 6.8100 1,049 7 5,303
2013-06-26 2013-06-24 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 15.75 -10,000 0
2013-06-26 2013-06-24 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -20,000 4,000
2013-06-26 2013-06-24 4 Geary Richard S ISIS Common Stock S - Sale D 25.1600 -10,000 -252 4,254
2013-06-26 2013-06-24 4 Geary Richard S ISIS Common Stock M - Exercise D 15.7500 10,000 158 14,254
2013-06-26 2013-06-24 4 Geary Richard S ISIS Common Stock S - Sale D 25.1600 -6,270 -158 4,254
2013-06-26 2013-06-24 4 Geary Richard S ISIS Common Stock M - Exercise D 15.3800 6,270 96 10,524
2013-06-26 2013-06-24 4 Geary Richard S ISIS Common Stock S - Sale D 25.2200 -13,730 -346 4,254
2013-06-26 2013-06-24 4 Geary Richard S ISIS Common Stock M - Exercise D 15.3800 13,730 211 17,984
2013-06-26 2013-06-25 4 Castleman Breaux ISIS Restricted Stock Units A - Award D 3,750 3,750
2013-06-26 2013-06-25 4 Castleman Breaux ISIS Director Stock Option (right to buy) A - Award D 26.66 22,500 22,500
2013-06-26 2013-06-26 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -20,000 30,000
2013-06-26 2013-06-26 4 CROOKE STANLEY T By Trust ISIS Common Stock S - Sale I 26.7000 -10,000 -267 785,391
2013-06-26 2013-06-26 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 27.1010 -20,000 -542 1,661
2013-06-26 2013-06-26 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8100 20,000 136 21,661
2013-06-26 2013-06-25 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -30,000 50,000
2013-06-26 2013-06-25 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 27.8650 -19,565 -545 1,661
2013-06-26 2013-06-25 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8100 19,565 133 21,226
2013-06-26 2013-06-25 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 28.3200 -10,435 -296 1,661
2013-06-26 2013-06-25 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8100 10,435 71 12,096
2013-06-26 2013-06-24 4 CROOKE STANLEY T By Trust ISIS Common Stock S - Sale I 25.2200 -13,730 -346 795,391
2013-06-26 2013-06-24 4 CROOKE STANLEY T By Trust ISIS Common Stock S - Sale I 25.1600 -16,270 -409 809,121
2013-06-24 2013-06-20 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 5.17 -10,000 0
2013-06-24 2013-06-20 4 WENDER JOSEPH H ISIS Common stock S - Sale D 20.9300 -5,447 -114 55,553
2013-06-24 2013-06-20 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 5.1700 10,000 52 61,000
2013-06-13 2013-06-11 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 15.75 -9,375 625
2013-06-13 2013-06-11 4 Monia Brett P ISIS Common Stock S - Sale D 23.7600 -9,375 -223 5,695
2013-06-13 2013-06-11 4 Monia Brett P ISIS Common Stock M - Exercise D 15.7500 9,375 148 15,070
2013-05-31 2013-05-30 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) M - Exercise D 5.17 -10,000 0
2013-05-31 2013-05-30 4 MUTO FREDERICK T ISIS Common Stock S - Sale D 21.9600 -10,000 -220 0
2013-05-31 2013-05-30 4 MUTO FREDERICK T ISIS Common Stock M - Exercise D 5.1700 10,000 52 10,000
2013-05-02 2013-05-01 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -6,145 0
2013-05-02 2013-05-01 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -23,800 0
2013-05-02 2013-05-01 4 BENNETT C FRANK ISIS Common Stock S - Sale D 22.2610 -6,145 -137 2,110
2013-05-02 2013-05-01 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 11.1200 6,145 68 8,255
2013-05-02 2013-05-01 4 BENNETT C FRANK ISIS Common Stock S - Sale D 22.2610 -23,800 -530 2,110
2013-05-02 2013-05-01 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 6.8100 23,800 162 25,910
2013-05-02 2013-04-30 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -30,000 6,145
2013-05-02 2013-04-30 4 BENNETT C FRANK ISIS Common Stock S - Sale D 22.5051 -30,000 -675 2,110
2013-05-02 2013-04-30 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 11.1200 30,000 334 32,110
2013-04-26 2013-04-24 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -10,417 0
2013-04-26 2013-04-24 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 22.3800 -10,417 -233 300
2013-04-26 2013-04-24 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 15.3800 10,417 160 10,717
2013-04-26 2013-04-25 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -18,400 0
2013-04-26 2013-04-25 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -7,454 0
2013-04-26 2013-04-25 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 22.4950 -18,400 -414 2,941
2013-04-26 2013-04-25 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 6.8100 18,400 125 21,341
2013-04-26 2013-04-25 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 22.4950 -7,454 -168 2,941
2013-04-26 2013-04-25 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.1200 7,454 83 10,395
2013-04-26 2013-04-24 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -30,000 7,454
2013-04-26 2013-04-24 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 22.1200 -30,000 -664 2,941
2013-04-26 2013-04-24 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.1200 30,000 334 32,941
2013-04-26 2013-04-24 4 CROOKE STANLEY T By Family Trust ISIS Common Stock S - Sale I 22.1200 -10,000 -221 825,391
2013-04-23 2013-04-19 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -2,042 9,000
2013-04-23 2013-04-19 4 Geary Richard S ISIS Common Stock S - Sale D 20.8000 -2,042 -42 4,254
2013-04-23 2013-04-19 4 Geary Richard S ISIS Common Stock M - Exercise D 11.1200 2,042 23 6,296
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -7,813 10,417
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -9,843 12,657
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 21.4300 -2,000 -43 300
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 15.3800 2,000 31 2,300
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 21.4100 -3,000 -64 300
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 15.3800 3,000 46 3,300
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 21.4000 -2,813 -60 300
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 15.3800 2,813 43 3,113
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 21.4900 -9,843 -212 300
2013-04-23 2013-04-22 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 14.4700 9,843 142 10,143
2013-04-23 2013-04-22 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -17,000 0
2013-04-23 2013-04-22 4 Monia Brett P ISIS Common Stock S - Sale D 21.2600 -17,000 -361 5,695
2013-04-23 2013-04-22 4 Monia Brett P ISIS Common Stock M - Exercise D 11.1200 17,000 189 22,695
2013-04-23 2013-04-19 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -2,500 17,000
2013-04-23 2013-04-19 4 Monia Brett P ISIS Common Stock S - Sale D 21.2500 -2,500 -53 5,695
2013-04-23 2013-04-19 4 Monia Brett P ISIS Common Stock M - Exercise D 11.1200 2,500 28 8,195
2013-04-23 2013-04-23 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -10,000 0
2013-04-23 2013-04-23 4 PARSHALL B LYNNE by daughter ISIS Employee Stock Option (right to buy) M - Exercise I 6.81 -10,000 0
2013-04-23 2013-04-23 4 PARSHALL B LYNNE by daughter ISIS Employee Stock Option (right to buy) M - Exercise I 6.81 -10,000 0
2013-04-23 2013-04-23 4 PARSHALL B LYNNE by daughter ISIS Common Stock S - Sale I 22.0967 -10,000 -221 0
2013-04-23 2013-04-23 4 PARSHALL B LYNNE by daughter ISIS Common Stock S - Sale I 22.0967 -10,000 -221 0
2013-04-23 2013-04-23 4 PARSHALL B LYNNE by daughter ISIS Common Stock M - Exercise I 6.8100 10,000 68 10,000
2013-04-23 2013-04-23 4 PARSHALL B LYNNE by daughter ISIS Common Stock M - Exercise I 6.8100 10,000 68 10,000
2013-04-23 2013-04-23 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 22.0967 -10,000 -221 2,941
2013-04-23 2013-04-23 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.1200 10,000 111 12,941
2013-04-23 2013-04-22 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -30,000 47,454
2013-04-23 2013-04-22 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 20.9900 -30,000 -630 2,941
2013-04-23 2013-04-22 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 11.1200 30,000 334 32,941
2013-04-23 2013-04-19 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 7.26 -30,000 0
2013-04-23 2013-04-19 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 20.0060 -30,000 -600 2,941
2013-04-23 2013-04-19 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 7.2600 30,000 218 32,941
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -3,900 11,150
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 8.00 -1,800 4,000
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -2,700 4,350
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -2,260 10
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.18 -10,660 10
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -6,000 0
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 22.1300 -3,900 -86 1,324
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 3,900 40 5,224
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 22.1300 -1,800 -40 1,324
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 1,800 14 3,124
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 22.1300 -2,700 -60 1,324
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 2,700 30 4,024
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 22.1300 -2,260 -50 1,324
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.4700 2,260 33 3,584
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 22.1300 -10,660 -236 1,324
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.1800 10,660 151 11,984
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 22.1300 -6,000 -133 1,324
2013-04-23 2013-04-23 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 15.3800 6,000 92 7,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -6,000 2,270
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.18 -1,000 10,670
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 15.38 -8,000 6,000
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 21.0100 -5,000 -105 1,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 15.3800 5,000 77 6,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 20.0060 -6,000 -120 1,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.4700 6,000 87 7,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 19.6000 -1,000 -20 1,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.1800 1,000 14 2,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 20.2500 -3,000 -61 1,324
2013-04-23 2013-04-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 15.3800 3,000 46 4,324
2013-04-23 2013-04-23 4 CROOKE STANLEY T By Family Trust ISIS Common Stock S - Sale I 22.0967 -30,000 -663 835,391
2013-04-23 2013-04-22 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 7.26 -20,000 0
2013-04-23 2013-04-22 4 CROOKE STANLEY T By Family Trust ISIS Common Stock S - Sale I 20.9900 -10,000 -210 865,391
2013-04-23 2013-04-22 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 20.9900 -20,000 -420 1,661
2013-04-23 2013-04-22 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 7.2600 20,000 145 21,661
2013-04-23 2013-04-19 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 7.26 -30,000 20,000
2013-04-23 2013-04-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 20.0060 -30,000 -600 1,661
2013-04-23 2013-04-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 7.2600 30,000 218 31,661
2013-04-15 2013-04-11 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -7,000 11,042
2013-04-15 2013-04-11 4 Geary Richard S ISIS Common Stock S - Sale D 19.5200 -7,000 -137 4,254
2013-04-15 2013-04-11 4 Geary Richard S ISIS Common Stock M - Exercise D 11.1200 7,000 78 11,254
2013-04-15 2013-04-12 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.18 -4,330 11,670
2013-04-15 2013-04-12 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.47 -1,130 8,270
2013-04-15 2013-04-12 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 19.6184 -4,330 -85 1,324
2013-04-15 2013-04-12 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.1800 4,330 61 5,654
2013-04-15 2013-04-12 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 19.6000 -1,130 -22 1,324
2013-04-15 2013-04-12 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.4700 1,130 16 2,454
2013-03-22 2013-03-21 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 14.18 -9,000 16,000
2013-03-22 2013-03-21 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 19.2600 -9,000 -173 1,324
2013-03-22 2013-03-21 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 14.1800 9,000 128 10,324
2013-03-22 2013-03-21 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -1,000 18,042
2013-03-22 2013-03-21 4 Geary Richard S ISIS Common Stock S - Sale D 19.5000 -1,000 -20 4,254
2013-03-22 2013-03-21 4 Geary Richard S ISIS Common Stock M - Exercise D 11.1200 1,000 11 5,254
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -174 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -174 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 9.22 -1,250 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 9.22 -1,250 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 16.32 -2,500 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 16.32 -2,500 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 9.77 -4,167 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 9.77 -4,167 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 13.88 -3,750 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 13.88 -3,750 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 9.22 -1,250 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 16.32 -2,500 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 13.88 -3,750 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -173 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 9.77 -4,166 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0000 -4,167 -75 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -4,167 -75 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 9.7700 4,167 41 4,167
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 9.7700 4,167 41 4,167
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -3,750 -68 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 13.8800 3,750 52 3,750
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0000 -174 -3 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 5.9300 174 1 174
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0000 -1,250 -22 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -1,250 -22 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 9.2200 1,250 12 1,250
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 9.2200 1,250 12 1,250
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0000 -2,500 -45 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 16.3200 2,500 41 2,500
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0000 -3,750 -68 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 13.8800 3,750 52 3,750
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -173 -3 100
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.9300 173 1 273
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -2,500 -45 100
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 16.3200 2,500 41 2,600
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -4,166 -75 100
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 9.7700 4,166 41 4,266
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -3,750 -68 100
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 13.8800 3,750 52 3,850
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -3,727 174
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -3,726 174
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -3,726 174
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -3,727 -67 0
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.9300 3,727 22 3,727
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0000 -3,726 -67 0
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -3,726 -67 0
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.9300 3,726 22 3,726
2013-03-21 2013-03-19 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 5.9300 3,726 22 3,726
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -174 -3 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.9300 174 1 174
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -1,250 -22 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 9.2200 1,250 12 1,250
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0000 -2,500 -45 0
2013-03-21 2013-03-20 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 16.3200 2,500 41 2,500
2013-03-21 2013-03-20 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -4,792 0
2013-03-21 2013-03-20 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -9,584 0
2013-03-21 2013-03-20 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 18.1300 -4,792 -87 300
2013-03-21 2013-03-20 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 11.1200 4,792 53 5,092
2013-03-21 2013-03-20 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 18.1300 -9,584 -174 300
2013-03-21 2013-03-20 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 11.1200 9,584 107 9,884
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.17 -6,667 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 5.17 -6,667 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -266 3,901
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Daughter ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -266 3,901
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.17 -6,666 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Director Stock Option (right to buy) M - Exercise I 5.93 -268 3,899
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0069 -6,667 -120 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0069 -6,667 -120 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 5.1700 6,667 34 6,667
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.1700 6,667 34 6,667
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Daughter ISIS Common Stock S - Sale I 18.0069 -266 -5 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0069 -266 -5 0
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.9300 266 2 266
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Daughter ISIS Common Stock M - Exercise I 5.9300 266 2 266
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0069 -6,666 -120 100
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.1700 6,666 34 6,766
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock S - Sale I 18.0069 -268 -5 100
2013-03-14 2013-03-13 4 KLEIN JOSEPH III By Son ISIS Common Stock M - Exercise I 5.9300 268 2 368
2013-03-07 2013-03-05 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -18,240 0
2013-03-07 2013-03-05 4 Monia Brett P ISIS Common Stock S - Sale D 16.8640 -18,240 -308 5,695
2013-03-07 2013-03-05 4 Monia Brett P ISIS Common Stock M - Exercise D 6.8100 18,240 124 23,935
2013-03-07 2013-03-05 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -5,040 0
2013-03-07 2013-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 16.8571 -5,040 -85 300
2013-03-07 2013-03-05 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 6.8100 5,040 34 5,340
2013-03-04 2013-03-04 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 11.12 -1,350 0
2013-03-04 2013-03-04 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 11.27 -10,351 7,050
2013-03-04 2013-03-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 15.8170 -1,350 -21 1,324
2013-03-04 2013-03-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.1200 1,350 15 2,674
2013-03-04 2013-03-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 15.8170 -10,350 -164 1,324
2013-03-04 2013-03-04 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 11.2700 10,350 117 11,674
2013-02-22 2013-02-21 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) M - Exercise D 5.17 -10,000 0
2013-02-22 2013-02-21 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 5.1700 10,000 52 39,300
2013-02-20 2013-02-19 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -1,600 15,050
2013-02-20 2013-02-19 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.8000 -1,600 -24 1,324
2013-02-20 2013-02-19 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 1,600 16 2,924
2013-02-20 2013-02-15 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -250 16,650
2013-02-20 2013-02-15 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -100 16,900
2013-02-20 2013-02-15 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.8200 -250 -4 1,324
2013-02-20 2013-02-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 250 3 1,574
2013-02-20 2013-02-15 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.8000 -100 -1 1,324
2013-02-20 2013-02-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 100 1 1,424
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 7.25 -5,200 14,300
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 8.00 -900 5,800
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.1700 -139 -2 1,324
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.1700 -5,200 -74 1,463
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 7.2500 5,200 38 6,663
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.1700 -900 -13 1,463
2013-02-14 2013-02-13 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 8.0000 900 7 2,363
2013-02-01 2013-01-30 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) A - Award D 14.69 62,280 62,280
2013-02-01 2013-01-30 4 PARSHALL B LYNNE ISIS Restricted Stock Units A - Award D 10,380 10,380
2013-02-01 2013-01-30 4 Geary Richard S ISIS Employee Stock Option (right to buy) A - Award D 14.69 33,540 33,540
2013-02-01 2013-01-30 4 Geary Richard S ISIS Restricted StockUnits A - Award D 5,590 5,590
2013-02-01 2013-01-30 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) A - Award D 14.69 34,000 34,000
2013-02-01 2013-01-30 4 BENNETT C FRANK ISIS Restricted Stock Units A - Award D 5,660 5,660
2013-02-01 2013-01-30 4 Monia Brett P ISIS Employee Stock Option (right to buy) A - Award D 14.69 34,000 34,000
2013-02-01 2013-01-30 4 Monia Brett P ISIS Restricted Stock Units A - Award D 5,660 5,660
2013-02-01 2013-01-30 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) A - Award D 14.69 133,180 133,180
2013-02-01 2013-01-30 4 CROOKE STANLEY T ISIS Restricted Stock Units A - Award D 22,190 22,190
2013-01-31 2013-01-30 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) M - Exercise D 10.29 -2,000 17,000
2013-01-31 2013-01-30 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.8200 -2,000 -30 1,463
2013-01-31 2013-01-30 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 10.2900 2,000 21 3,463
2013-01-31 2013-01-29 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 13.4000 -300 -4 1,463
2013-01-17 2013-01-16 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 14.0000 -759 -11 2,941
2013-01-17 2013-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units M - Exercise D -1,715 5,145
2013-01-17 2013-01-15 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 1,715 3,700
2013-01-17 2013-01-17 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 14.1600 -242 -3 1,763
2013-01-17 2013-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units A - Award D 2,615 2,615
2013-01-17 2013-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units A - Award D 1,250 1,250
2013-01-17 2013-01-15 4 O'NEIL PATRICK R. ISIS Restricted Stock Units M - Exercise D -542 1,624
2013-01-17 2013-01-15 4 O'NEIL PATRICK R. ISIS Common Stock M - Exercise D 542 2,005
2013-01-17 2013-01-16 4 HOUGEN ELIZABETH L ISIS Common Stock S - Sale D 14.0000 -242 -3 300
2013-01-17 2013-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units A - Award D 2,615 2,615
2013-01-17 2013-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units A - Award D 1,250 1,250
2013-01-17 2013-01-15 4 HOUGEN ELIZABETH L ISIS Restricted Stock Units M - Exercise D -542 1,624
2013-01-17 2013-01-15 4 HOUGEN ELIZABETH L ISIS Common Stock M - Exercise D 542 542
2013-01-17 2013-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 14.0000 -95 -1 5,695
2013-01-17 2013-01-16 4 Monia Brett P ISIS Common Stock S - Sale D 14.0000 -235 -3 5,581
2013-01-17 2013-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -209 624
2013-01-17 2013-01-15 4 Monia Brett P ISIS Restricted Stock Units M - Exercise D -528 1,582
2013-01-17 2013-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 209 5,790
2013-01-17 2013-01-15 4 Monia Brett P ISIS Common Stock M - Exercise D 528 5,816
2013-01-17 2013-01-16 4 Geary Richard S ISIS Common Stock S - Sale D 14.0000 -345 -5 4,254
2013-01-17 2013-01-15 4 Geary Richard S ISIS Restricted Stock Units M - Exercise D -776 2,327
2013-01-17 2013-01-15 4 Geary Richard S ISIS Common Stock M - Exercise D 776 4,599
2013-01-17 2013-01-16 4 BENNETT C FRANK ISIS Common Stock S - Sale D 14.0000 -309 -4 2,110
2013-01-17 2013-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units M - Exercise D -695 2,083
2013-01-17 2013-01-15 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 695 2,419
2013-01-17 2013-01-16 4 CROOKE STANLEY T by wife ISIS Common Stock S - Sale I 13.9994 -143 -2 174
2013-01-17 2013-01-16 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 13.9999 -1,317 -18 1,661
2013-01-17 2013-01-15 4 CROOKE STANLEY T by wife ISIS Restricted Stock Units A - Award I 1,666 1,666
2013-01-17 2013-01-15 4 CROOKE STANLEY T by wife ISIS Restricted Stock Units M - Exercise I -317 949
2013-01-17 2013-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units M - Exercise D -2,978 8,932
2013-01-17 2013-01-15 4 CROOKE STANLEY T by wife ISIS Common Stock M - Exercise I 317 317
2013-01-17 2013-01-15 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 2,978 2,978
2013-01-11 2013-01-11 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 6.81 10,000 10,000
2013-01-11 2013-01-11 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 6.81 10,000 10,000
2013-01-11 2013-01-11 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) G - Gift D 6.81 -20,000 18,400
2013-01-04 2013-01-04 4 O'NEIL PATRICK R. ISIS Common Stock S - Sale D 10.7600 -1,296 -14 1,463
2013-01-03 3 O'NEIL PATRICK R. ISIS Common Stock D 2,328
2013-01-03 3 HOUGEN ELIZABETH L ISIS No securities are beneficially owned D 0
2013-01-03 2013-01-03 4 Geary Richard S ISIS Common Stock S - Sale D 10.8400 -265 -3 3,823
2013-01-03 2013-01-01 4 Geary Richard S ISIS Common Stock J - Other D 8.8740 898 8 4,088
2013-01-03 2013-01-03 4 Monia Brett P ISIS Common Stock S - Sale D 10.8400 -311 -3 5,288
2013-01-03 2013-01-01 4 Monia Brett P ISIS Common Stock J - Other D 8.8740 215 2 5,599
2013-01-03 2013-01-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 8.8740 447 4 1,724
2013-01-03 2013-01-02 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) A - Award D 10.82 15,700 15,700
2013-01-03 2013-01-02 4 HOUGEN ELIZABETH L ISIS Employee Stock Option (right to buy) A - Award D 10.82 7,500 7,500
2013-01-03 2013-01-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) A - Award D 10.82 15,700 15,700
2013-01-03 2013-01-02 4 O'NEIL PATRICK R. ISIS Employee Stock Option (right to buy) A - Award D 10.82 7,500 7,500
2013-01-03 2013-01-01 4 O'NEIL PATRICK R. ISIS Common Stock J - Other D 8.8740 431 4 2,759
2013-01-03 2013-01-02 4 CROOKE STANLEY T By Wife ISIS Employee Stock Option (right to buy) A - Award I 10.82 10,000 10,000
2012-12-17 2012-12-13 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -6,000 0
2012-12-17 2012-12-13 4 Geary Richard S ISIS Common Stock S - Sale D 9.6251 -6,000 -58 3,190
2012-12-17 2012-12-13 4 Geary Richard S ISIS Common Stock M - Exercise D 5.2500 6,000 32 9,190
2012-09-21 2012-09-21 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 6.84 -29,462 0
2012-09-21 2012-09-21 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 14.0600 -29,462 -414 0
2012-09-21 2012-09-21 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8400 29,462 202 29,462
2012-09-21 2012-09-20 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 6.84 -20,538 29,462
2012-09-21 2012-09-20 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -9,462 0
2012-09-21 2012-09-20 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 15.0080 20,538 308 0
2012-09-21 2012-09-20 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 6.8400 20,538 140 20,538
2012-09-21 2012-09-20 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 15.0080 -9,462 -142 0
2012-09-21 2012-09-20 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 9,462 50 9,462
2012-09-21 2012-09-19 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -30,000 9,462
2012-09-21 2012-09-19 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 14.8150 -30,000 -444 0
2012-09-21 2012-09-19 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 30,000 158 30,000
2012-09-17 2012-09-13 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -27,074 39,462
2012-09-17 2012-09-13 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 14.5500 -27,074 -394 0
2012-09-17 2012-09-13 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 27,074 142 27,074
2012-09-11 2012-09-07 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 6.84 -5,000 0
2012-09-11 2012-09-07 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 6.84 -5,000 0
2012-09-11 2012-09-07 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 6.84 -2,506 0
2012-09-11 2012-09-07 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.1200 -5,000 -76 0
2012-09-11 2012-09-07 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.1200 -5,000 -76 0
2012-09-11 2012-09-07 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 6.8400 5,000 34 5,000
2012-09-11 2012-09-07 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 6.8400 5,000 34 5,000
2012-09-11 2012-09-07 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 15.1200 -2,506 -38 1,985
2012-09-11 2012-09-07 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 6.8400 2,506 17 4,491
2012-09-06 2012-09-06 4 Monia Brett P ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -12,031 0
2012-09-06 2012-09-06 4 Monia Brett P ISIS Common Stock S - Sale D 15.2500 -12,031 -183 5,384
2012-09-06 2012-09-06 4 Monia Brett P ISIS Common Stock M - Exercise D 5.2500 12,031 63 17,415
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 5.25 -5,000 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 6.84 -5,000 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 6.84 -5,000 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 5.25 -5,000 0
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to uy) M - Exercise D 6.84 -2,494 2,506
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -7,506 0
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.0020 -5,000 -75 0
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.0020 -5,000 -75 0
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 5.2500 5,000 26 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 5.2500 5,000 26 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.0350 -5,000 -75 0
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.0350 -5,000 -75 0
2012-09-06 2012-09-06 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 6.8400 5,000 34 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE Bu daughter ISIS Common Stock M - Exercise I 6.8400 5,000 34 5,000
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 15.0020 -5,000 -75 1,985
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 5.2500 5,000 26 6,985
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 15.0350 -2,506 -38 1,985
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 5.2500 2,506 13 4,491
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 15.0350 -2,494 -37 1,985
2012-09-06 2012-09-06 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 6.8400 2,494 17 4,479
2012-09-06 2012-09-05 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -2,000 7,506
2012-09-06 2012-09-05 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 15.0000 -2,000 -30 1,985
2012-09-06 2012-09-05 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 5.2500 2,000 10 3,985
2012-09-06 2012-09-04 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -10,000 5,000
2012-09-06 2012-09-04 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 5.25 -10,000 5,000
2012-09-06 2012-09-04 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) M - Exercise I 5.25 -10,000 5,000
2012-09-06 2012-09-04 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.0010 -10,000 -150 0
2012-09-06 2012-09-04 4 PARSHALL B LYNNE By daughter ISIS Common Stock S - Sale I 15.0010 -10,000 -150 0
2012-09-06 2012-09-04 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 5.2500 10,000 52 10,000
2012-09-06 2012-09-04 4 PARSHALL B LYNNE By daughter ISIS Common Stock M - Exercise I 5.2500 10,000 52 10,000
2012-09-06 2012-09-04 4 PARSHALL B LYNNE ISIS Common Stock S - Sale D 15.0010 -10,000 -150 1,985
2012-09-06 2012-09-04 4 PARSHALL B LYNNE ISIS Common Stock M - Exercise D 5.2500 10,000 52 11,985
2012-09-06 2012-09-06 4 REED JOHN C ISIS Director Stock Option (right to buy) M - Exercise D 5.17 -4,900 0
2012-09-06 2012-09-06 4 REED JOHN C ISIS Common Stock S - Sale D 15.1750 -4,900 -74 0
2012-09-06 2012-09-06 4 REED JOHN C ISIS Common Stock M - Exercise D 5.1700 4,900 25 4,900
2012-09-06 2012-09-04 4 REED JOHN C ISIS Director Stock Option (right to buy) M - Exercise D 5.17 -5,100 4,900
2012-09-06 2012-09-04 4 REED JOHN C ISIS Common Stock S - Sale D 15.1700 -5,100 -77 0
2012-09-06 2012-09-04 4 REED JOHN C ISIS Common Stock M - Exercise D 5.1700 5,100 26 5,100
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 5.25 -6,000 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 5.25 -4,687 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) M - Exercise I 6.84 -1,925 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -17,388 66,536
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 15.0020 -6,000 -90 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 5.2500 6,000 32 6,000
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 15.0020 -306 -5 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 5.2500 306 2 306
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 15.0350 -4,381 -66 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 5.2500 4,381 23 4,381
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock S - Sale I 15.0350 -1,925 -29 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T By wife ISIS Common Stock M - Exercise I 6.8400 1,925 13 1,925
2012-09-06 2012-09-06 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 15.0350 -8,694 -131 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 8,694 46 8,694
2012-09-06 2012-09-06 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 15.0020 -8,694 -130 0
2012-09-06 2012-09-06 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 8,694 46 8,694
2012-09-06 2012-09-05 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -15,000 83,924
2012-09-06 2012-09-05 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 14.8230 -15,000 -222 0
2012-09-06 2012-09-05 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 15,000 79 15,000
2012-09-06 2012-09-04 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -30,000 98,924
2012-09-06 2012-09-04 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 14.1085 -30,000 -423 0
2012-09-06 2012-09-04 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 5.2500 30,000 158 30,000
2012-07-11 2012-07-09 4 REED JOHN C ISIS Director Stock Option (right to buy) M - Exercise D 3.95 -10,000 0
2012-07-11 2012-07-09 4 REED JOHN C ISIS Common Stock S - Sale D 13.9900 -10,000 -140 0
2012-07-11 2012-07-09 4 REED JOHN C ISIS Common Stock M - Exercise D 3.9500 10,000 40 10,000
2012-07-11 2012-07-09 4 Geary Richard S ISIS Employee Stock Option (right to buy) M - Exercise D 5.25 -5,686 6,000
2012-07-11 2012-07-09 4 Geary Richard S ISIS Common Stock S - Sale D 13.4500 -1,000 -13 3,190
2012-07-11 2012-07-09 4 Geary Richard S ISIS Common Stock M - Exercise D 5.2500 1,000 5 4,190
2012-07-11 2012-07-09 4 Geary Richard S ISIS Common Stock S - Sale D 13.4900 -2,000 -27 3,190
2012-07-11 2012-07-09 4 Geary Richard S ISIS Common Stock M - Exercise D 5.2500 2,000 10 5,190
2012-07-11 2012-07-09 4 Geary Richard S ISIS Common Stock S - Sale D 13.4700 -2,686 -36 3,190
2012-07-11 2012-07-09 4 Geary Richard S ISIS Common Stock M - Exercise D 5.2500 2,686 14 5,876
2012-07-11 2012-07-09 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 6.81 -5,000 23,800
2012-07-11 2012-07-09 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 6.84 -5,500 0
2012-07-11 2012-07-09 4 BENNETT C FRANK ISIS Common Stock S - Sale D 13.5100 -5,000 -68 1,277
2012-07-11 2012-07-09 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 6.8100 5,000 34 6,277
2012-07-11 2012-07-09 4 BENNETT C FRANK ISIS Common Stock S - Sale D 13.5100 -5,500 -74 1,277
2012-07-11 2012-07-09 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 6.8400 5,500 38 6,777
2012-07-03 2012-07-03 4 Geary Richard S ISIS Common Stock S - Sale D 12.9100 -2,434 -31 3,190
2012-07-03 2012-07-01 4 Geary Richard S ISIS Common Stock J - Other D 6.1285 1,300 8 5,624
2012-07-03 2012-07-02 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) A - Award D 12.94 11,250 11,250
2012-07-03 2012-07-02 4 WENDER JOSEPH H ISIS Restricted Stock Units A - Award D 1,250 1,250
2012-07-03 2012-07-02 4 REED JOHN C ISIS Director Stock Option (right to buy) A - Award D 12.94 11,250 11,250
2012-07-03 2012-07-02 4 REED JOHN C ISIS Restricted Stock Units A - Award D 1,250 1,250
2012-07-03 2012-07-03 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) M - Exercise D 6.84 -6,000 5,500
2012-07-03 2012-07-03 4 BENNETT C FRANK ISIS Common Stock S - Sale D 12.9100 -6,000 -77 1,277
2012-07-03 2012-07-03 4 BENNETT C FRANK ISIS Common Stock M - Exercise D 6.8400 6,000 41 7,277
2012-07-03 2012-07-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 6.1285 648 4 1,277
2012-07-03 2012-07-02 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) A - Award D 12.94 11,250 11,250
2012-07-03 2012-07-02 4 BERTHELSEN SPENCER R ISIS Restricted Stock Units A - Award D 1,250 1,250
2012-07-03 2012-07-03 4 Monia Brett P ISIS Common Stock S - Sale D 12.9200 -587 -8 5,384
2012-07-03 2012-07-01 4 Monia Brett P ISIS Common Stock J - Other D 6.1285 311 2 5,971
2012-07-03 2012-07-02 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) A - Award D 12.94 11,250 11,250
2012-07-03 2012-07-02 4 MUTO FREDERICK T ISIS Restricted Stock Units A - Award D 1,250 1,250
2012-07-03 2012-07-02 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) A - Award D 12.94 11,250 11,250
2012-07-03 2012-07-02 4 KLEIN JOSEPH III ISIS Restricted Stock Units A - Award D 1,250 1,250
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) M - Exercise D 8.15 -10,000 0
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.6200 -172 -2 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 172 1 29,472
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.6000 -1,600 -19 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 1,600 13 30,900
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5900 -100 -1 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 100 1 29,400
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5820 -1,500 -17 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 1,500 12 30,800
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5800 -3,500 -41 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 3,500 29 32,800
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5600 -700 -8 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 700 6 30,000
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5500 -495 -6 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 495 4 29,795
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5400 -205 -2 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 205 2 29,505
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5300 -228 -3 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 228 2 29,528
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5100 -500 -6 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 500 4 29,800
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.5000 -200 -2 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 200 2 29,500
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 200 2 29,500
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.4930 -300 -3 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 300 2 29,600
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 8.1500 300 2 29,600
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.4900 -200 -2 29,300
2012-06-25 2012-06-25 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 11.4800 -300 -3 29,300
2012-06-22 2012-06-22 4 REED JOHN C ISIS Director Stock Option (right to buy) M - Exercise D 8.15 -10,000 0
2012-06-22 2012-06-22 4 REED JOHN C ISIS Common Stock S - Sale D 11.0600 -10,000 -111 0
2012-06-22 2012-06-22 4 REED JOHN C ISIS Common Stock M - Exercise D 8.1500 10,000 82 10,000
2012-06-14 2012-06-14 4 Geary Richard S ISIS Common Stock S - Sale D 10.8600 -1,579 -17 4,324
2012-06-13 2012-06-12 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) M - Exercise D 8.15 -10,000 0
2012-06-13 2012-06-12 4 WENDER JOSEPH H ISIS Common Stock M - Exercise D 8.1500 10,000 82 51,000
2012-05-22 2012-05-22 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) M - Exercise D 9.40 -17,269 0
2012-05-22 2012-05-22 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 9.5600 -17,269 -165 29,300
2012-05-22 2012-05-22 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 9.4000 17,269 162 46,569
2012-05-22 2012-05-21 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) M - Exercise D 9.40 -2,731 17,269
2012-05-22 2012-05-21 4 BERTHELSEN SPENCER R ISIS Common Stock S - Sale D 9.4200 -2,731 -26 29,300
2012-05-22 2012-05-21 4 BERTHELSEN SPENCER R ISIS Common Stock M - Exercise D 9.4000 2,731 26 32,031
2012-03-07 2012-01-03 4/A BENNETT C FRANK ISIS Employee Stock Option (right to buy) A - Award D 7.25 25,013 25,013
2012-03-07 2012-01-01 4/A BENNETT C FRANK ISIS Common Stock J - Other D 6.1285 324 2 629
2012-03-07 3/A Monia Brett P ISIS Common Stock D 5,073
2012-01-17 2012-01-15 4 BENNETT C FRANK ISIS Restricted Stock Units A - Award D 2,778 2,778
2012-01-17 2012-01-15 4 Geary Richard S ISIS Restricted Stock Units A - Award D 3,103 3,103
2012-01-17 2012-01-15 4 PARSHALL B LYNNE ISIS Restricted Stock Units A - Award D 6,860 6,860
2012-01-17 2012-01-15 4 Monia Brett P ISIS Restricted Stock Units A - Award D 2,110 2,110
2012-01-17 2012-01-15 4 Monia Brett P ISIS Restricted Stock Units A - Award D 833 833
2012-01-17 2012-01-15 4 CROOKE STANLEY T By wife ISIS Restricted Stock Units A - Award I 1,266 1,266
2012-01-17 2012-01-15 4 CROOKE STANLEY T ISIS Restricted Stock Units A - Award D 11,910 11,910
2012-01-13 2012-01-13 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 5.25 10,000 15,000
2012-01-13 2012-01-13 4 PARSHALL B LYNNE By daughter ISIS Employee Stock Option (right to buy) G - Gift I 5.25 10,000 15,000
2012-01-13 2012-01-13 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) G - Gift D 5.25 -20,000 19,506
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 9.22 1,250 1,250
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 9.22 1,250 1,250
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 16.32 2,500 2,500
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 16.32 2,500 2,500
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 13.88 3,750 3,750
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 13.88 3,750 3,750
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 9.77 4,167 4,167
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 9.77 4,167 4,167
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 9.22 1,250 1,250
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 16.32 2,500 2,500
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 13.88 3,750 3,750
2012-01-05 2012-01-04 4 KLEIN JOSEPH III By Trust ISIS Employee Stock Option (right to buy) G - Gift I 9.77 4,166 4,166
2012-01-05 2012-01-04 4 KLEIN JOSEPH III ISIS Employee Stock Option (right to buy) G - Gift D 9.22 -3,750 11,250
2012-01-05 2012-01-04 4 KLEIN JOSEPH III ISIS Employee Stock Option (right to buy) G - Gift D 16.32 -7,500 7,500
2012-01-05 2012-01-04 4 KLEIN JOSEPH III ISIS Employee Stock Option (right to buy) G - Gift D 13.88 -11,250 3,750
2012-01-05 2012-01-04 4 KLEIN JOSEPH III ISIS Employee Stock Option (right to buy) G - Gift D 9.77 -12,500 0
2012-01-03 2011-12-30 4 KLEIN JOSEPH III By Trust ISIS Director Stock Option (right to buy) G - Gift I 5.93 4,167 4,167
2012-01-03 2011-12-30 4 KLEIN JOSEPH III By Trust ISIS Director Stock Option (right to buy) G - Gift I 5.93 4,167 4,167
2012-01-03 2011-12-30 4 KLEIN JOSEPH III By Trust ISIS Director Stock Option (right to buy) G - Gift I 5.17 6,667 6,667
2012-01-03 2011-12-30 4 KLEIN JOSEPH III By Trust ISIS Director Stock Option (right to buy) G - Gift I 5.17 6,667 6,667
2012-01-03 2011-12-30 4 KLEIN JOSEPH III By Trust ISIS Director Stock Option (right to buy) G - Gift I 5.93 4,166 4,166
2012-01-03 2011-12-30 4 KLEIN JOSEPH III By Trust ISIS Director Stock Option (right to buy) G - Gift I 5.17 6,666 6,666
2012-01-03 2011-12-30 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) G - Gift D 5.93 -12,500 0
2012-01-03 2011-12-30 4 KLEIN JOSEPH III ISIS Director Stock Option (right to buy) G - Gift D 5.17 -20,000 0
2012-01-03 3 Monia Brett P ISIS Common Stock D 5,073
2012-01-03 2012-01-03 4 Monia Brett P ISIS Employee Stock Option (right to buy) A - Award D 7.25 18,993 18,993
2012-01-03 2012-01-01 4 Monia Brett P ISIS Employee Stock Option (right to buy) A - Award D 7.21 7,500 7,500
2012-01-03 2012-01-01 4 Monia Brett P ISIS Common Stock J - Other D 6.1285 -587 -4 5,660
2012-01-03 2012-01-03 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) A - Award D 7.25 25,013 25,013
2012-01-03 2011-12-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 6.1285 324 2 629
2012-01-03 2012-01-03 4 Geary Richard S ISIS Employee Stock Option (right to buy) A - Award D 7.25 27,935 27,935
2012-01-03 2012-01-01 4 Geary Richard S ISIS Common Stock J - Other D 6.1285 1,625 10 5,903
2012-01-03 2012-01-03 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) A - Award D 7.25 61,749 61,749
2012-01-03 2012-01-03 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) A - Award I 7.25 11,404 11,404
2012-01-03 2012-01-03 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) A - Award D 7.25 107,203 107,203
2010-01-05 2010-01-04 4 CROOKE STANLEY T By wife ISIS Employee Stock Option (right to buy) A - Award I 11.27 6,600 6,600
2010-01-05 2010-01-04 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) A - Award D 11.27 119,163 119,163
2010-01-05 2010-01-04 4 Geary Richard S ISIS Employee Stock Option (right to buy) A - Award D 11.27 32,640 32,640
2010-01-05 2010-01-01 4 Geary Richard S ISIS Common Stock J - Other D 9.4435 1,579 15 1,579
2010-01-05 2010-01-04 4 PARSHALL B LYNNE ISIS Employee Stock Option (right to buy) A - Award D 11.27 63,554 63,554
2010-01-05 2010-01-04 4 BENNETT C FRANK ISIS Employee Stock Option (right to buy) A - Award D 11.27 27,805 27,805
2010-01-05 2010-01-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 9.4435 195 2 1,171
2008-08-19 3 Geary Richard S ISIS No securities are beneficially owned D 0
2007-12-05 3 XANTHOPOULOS KLEANTHIS G ISIS No securities are beneficially owned D 0
2007-02-05 3 JONAS JEFFREY M ISIS No securities are beneficially owned D 0
2005-12-15 3 KLEIN JOSEPH III Owned by Son ISIS Common Stock I 100
2005-07-06 2005-07-01 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) A - Award D 3.95 10,000 10,000
2005-07-06 2005-07-01 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) A - Award D 3.95 10,000 10,000
2005-07-06 2005-07-01 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) A - Award D 11,111.00 10,000 10,000
2005-07-06 2005-07-01 4 DiMarchi Richard D ISIS Director Stock Option (right to buy) A - Award D 3.95 10,000 10,000
2005-07-06 2005-07-01 4 GABRIELI CHRISTOPHER ISIS Director Stock Option (right to buy) A - Award D 3.95 10,000 10,000
2005-07-06 2005-07-01 4 REED JOHN C ISIS Director Stock Option (right to buy) A - Award D 3.95 10,000 10,000
2005-05-26 3 Wedel Mark K ISIS Common Stock D 7,204
2004-12-27 2004-12-22 4 LEVIN ARTHUR A ISIS Employee Stock Option (right to buy) M - Exercise D 5.88 -1,000 3,683
2004-12-27 2004-12-22 4 LEVIN ARTHUR A ISIS Common Stock S - Sale D 6.2000 -1,000 -6 1,492
2004-12-27 2004-12-22 4 LEVIN ARTHUR A ISIS Common Stock M - Exercise D 5.8750 1,000 6 2,492
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Employee Stock Option (right to buy) M - Exercise D 5.88 -5,500 7,683
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Common Stock S - Sale D 6.1500 -1,600 -10 1,492
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Common Stock M - Exercise D 5.8750 1,600 9 3,092
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Common Stock S - Sale D 6.1900 -1,000 -6 1,492
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Common Stock M - Exercise D 5.8750 1,000 6 2,492
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Common Stock S - Sale D 6.2000 -2,900 -18 1,492
2004-12-13 2004-12-10 4 LEVIN ARTHUR A ISIS Common Stock M - Exercise D 5.8750 2,900 17 4,392
2004-12-01 2004-12-01 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 4.00 -5,000 7,051
2004-12-01 2004-12-01 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 4.8958 -5,000 -24 922,241
2004-12-01 2004-12-01 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 4.0000 5,000 20 927,241
2004-12-01 2004-11-30 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 4.00 -4,000 12,051
2004-12-01 2004-11-30 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 4.7050 -4,000 -19 922,241
2004-12-01 2004-11-30 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 4.0000 4,000 16 926,241
2004-12-01 2004-11-29 4 CROOKE STANLEY T ISIS Employee Stock Option (right to buy) M - Exercise D 4.00 -1,549 16,051
2004-12-01 2004-11-29 4 CROOKE STANLEY T ISIS Common Stock S - Sale D 4.6179 -1,549 -7 922,241
2004-12-01 2004-11-29 4 CROOKE STANLEY T ISIS Common Stock M - Exercise D 4.0000 1,549 6 923,790
2004-07-02 2004-07-01 4 GABRIELI CHRISTOPHER ISIS Director Stock Option (right to buy) A - Award D 5.72 10,000 10,000
2004-07-02 2004-07-01 4 BERTHELSEN SPENCER R ISIS Director Stock Option (right to buy) A - Award D 5.72 10,000 10,000
2004-07-02 2004-07-01 4 MUTO FREDERICK T ISIS Director Stock Option (right to buy) A - Award D 5.72 10,000 10,000
2004-07-02 2004-07-01 4 REED JOHN C ISIS Director Stock Option (right to buy) A - Award D 5.72 10,000 10,000
2004-07-02 2004-07-01 4 SKALETSKY MARK B ISIS Director Stock Option (right to buy) A - Award D 5.72 10,000 10,000
2004-07-02 2004-07-01 4 WENDER JOSEPH H ISIS Director Stock Option (right to buy) A - Award D 5.72 10,000 10,000
2004-07-02 2004-07-01 4 STEIN ARON ISIS Common Stock J - Other D 4.8620 600 3 1,536
2004-07-02 2004-07-01 4 LEVIN ARTHUR A ISIS Common Stock J - Other D 4.8620 272 1 1,492
2004-07-02 2004-07-01 4 BENNETT C FRANK ISIS Common Stock J - Other D 4.8620 295 1 858
2004-07-02 2004-07-01 4 ECKER DAVID J By Trust ISIS Common Stock J - Other I 4.8620 2,920 14 35,485
P
Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.
S
Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.
A
Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)
C
Konversi turunan
D
Penjualan atau pengalihan sekuritas kembali ke perusahaan.
F
Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.
G
Pemberian sekuritas oleh atau kepada orang dalam.
K
Swap ekuitas dan transaksi lindung nilai serupa
M
Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)
V
Transaksi yang dilaporkan secara sukarela pada Formulir 4.
J
Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)
Other Listings
IT:1IONS € 51.56
MX:IONS
GB:0JDI
DE:ISI € 50.44
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