Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

Pendahuluan

Halaman ini memberikan analisis komprehensif tentang sejarah perdagangan orang dalam yang diketahui dari O'neil Patrick R.. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Adalah ilegal bagi orang dalam untuk melakukan perdagangan di perusahaan mereka berdasarkan informasi spesifik yang tidak dipublikasikan. Ini tidak berarti bahwa mereka dilarang melakukan perdagangan apa pun di perusahaan mereka sendiri. Namun, mereka harus melaporkan semua perdagangan kepada SEC melalui Formulir 4. Terlepas dari pembatasan ini, penelitian akademis menunjukkan bahwa orang dalam - secara umum - cenderung mengungguli pasar di perusahaan mereka sendiri.

Rata-rata Profitabilitas Perdagangan

Profitabilitas perdagangan rata-rata adalah pengembalian rata-rata dari semua pembelian pasar terbuka yang dilakukan oleh orang dalam dalam tiga tahun terakhir. Untuk menghitung ini, kami memeriksa setiap pembelian pasar terbuka yang tidak direncanakan yang dilakukan oleh orang dalam, tidak termasuk semua perdagangan yang ditandai sebagai bagian dari rencana perdagangan 10b5-1. Kami kemudian menghitung kinerja rata-rata dari perdagangan tersebut selama 3, 6, dan 12 bulan, dengan merata-ratakan setiap durasi tersebut untuk menghasilkan metrik kinerja akhir untuk setiap perdagangan. Terakhir, kami merata-ratakan semua metrik kinerja untuk menghitung metrik kinerja untuk orang dalam. Daftar ini hanya mencakup orang dalam yang telah melakukan setidaknya tiga perdagangan dalam dua tahun terakhir.

Jika profitabilitas perdagangan orang dalam ini adalah "N/A", maka orang dalam tersebut belum melakukan pembelian di pasar terbuka dalam tiga tahun terakhir, atau perdagangan yang mereka lakukan terlalu baru untuk menghitung metrik kinerja yang andal.

Frekuensi Pembaruan: Setiap Hari

Lihat daftar pedagang dalam perusahaan yang paling menguntungkan.

Perusahaan dengan Posisi Orang Dalam yang Dilaporkan

Pengajuan SEC menunjukkan bahwa O'neil Patrick R. telah melaporkan kepemilikan atau perdagangan di perusahaan-perusahaan berikut:

Keamanan Judul Kepemilikan Terakhir yang Dilaporkan
US:IONS / Ionis Pharmaceuticals, Inc. EVP CLO & General Counsel 57,130
Cara Membaca Grafik

Grafik berikut menunjukkan kinerja saham sekuritas setelah setiap perdagangan pasar terbuka yang tidak direncanakan yang dilakukan oleh O'neil Patrick R.. Perdagangan yang tidak direncanakan adalah perdagangan yang tidak dilakukan sebagai bagian dari rencana perdagangan 10b5-1. Kinerja saham digambarkan sebagai perubahan persentase kumulatif dalam harga saham. Misalnya, jika perdagangan orang dalam dilakukan pada 1 Januari 2019, grafik akan menunjukkan perubahan persentase harian sekuritas hingga saat ini. Jika harga saham naik dari $10 menjadi $15 selama periode ini, perubahan persentase kumulatif dalam harga saham akan menjadi 50%. Perubahan harga dari $10 menjadi $20 akan menjadi 100%, dan perubahan harga dari $10 menjadi $5 akan menjadi -50%.

Pada akhirnya, kita mencoba menentukan seberapa erat korelasi perdagangan orang dalam dengan pengembalian berlebih (positif atau negatif) pada harga saham untuk melihat apakah orang dalam tersebut mengatur waktu perdagangannya untuk mendapatkan keuntungan dari informasi orang dalam. Pertimbangkan situasi di mana orang dalam melakukan hal ini. Dalam situasi ini, kita akan mengharapkan (a) pengembalian positif setelah pembelian, atau (b) pengembalian negatif setelah penjualan. Dalam kasus (a), grafik PEMBELIAN akan menunjukkan serangkaian kurva yang miring ke atas, menunjukkan pengembalian positif setelah setiap transaksi pembelian. Dalam kasus (b), grafik PENJUALAN akan menunjukkan serangkaian kurva yang miring ke bawah, menunjukkan pengembalian negatif setelah setiap transaksi penjualan.

Namun, ini saja tidak cukup untuk menarik kesimpulan. Jika, misalnya, harga saham perusahaan berada dalam tren kenaikan non-siklikal selama bertahun-tahun, maka kita akan mengharapkan semua plot pasca-pembelian memiliki kemiringan ke atas. Demikian pula, penurunan non-siklikal selama bertahun-tahun akan menghasilkan plot pasca-perdagangan dengan kemiringan ke bawah. Tak satu pun dari grafik ini akan menunjukkan aktivitas perdagangan orang dalam.

Indikator terkuat adalah situasi di mana harga saham sangat siklikal, dan terdapat sinyal positif pada grafik PEMBELIAN dan plot negatif pada grafik PENJUALAN. Situasi ini akan sangat menunjukkan adanya orang dalam yang mengatur waktu perdagangan untuk keuntungan finansial mereka.

Pembelian Orang Dalam IONS / Ionis Pharmaceuticals, Inc. - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di IONS / Ionis Pharmaceuticals, Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham
Dilaporkan
Harga
Disesuaikan
Saham
Disesuaikan
Harga
Dasar Biaya Hari-hari menuju
Maksimal
Harga di
Maksimal
Maksimal
Keuntungan ($)
Maksimum Pengembalian (%)
Tidak ada transaksi pasar terbuka tak terduga yang diketahui untuk kombinasi orang dalam dan sekuritas ini.

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Penjualan Orang Dalam IONS / Ionis Pharmaceuticals, Inc. - Analisis Kerugian Jangka Pendek

Pada bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan internal pasar terbuka yang tidak direncanakan yang dilakukan di IONS / Ionis Pharmaceuticals, Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoritis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan Ticker Orang Dalam Dilaporkan
Saham
Dilaporkan
Harga
Disesuaikan
Saham
Disesuaikan
Harga
Dasar Biaya Hari-hari menuju
Menit
Harga di
Menit
Kerugian Maksimal
Dihindari ($)
Kerugian Maksimal
Dihindari (%)
2025-01-31 IONS O'NEIL PATRICK R. 1,406 32.4926 1,406 32.4926 45,685 67 25.5100 -9,817 -21.49
2025-01-16 IONS O'NEIL PATRICK R. 7,360 32.8300 7,360 32.8300 241,629
2024-02-02 IONS O'NEIL PATRICK R. 1,961 49.6738 1,961 49.6738 97,410
2024-02-02 IONS O'NEIL PATRICK R. 1,995 49.6738 1,995 49.6738 99,099
2024-01-25 IONS O'NEIL PATRICK R. 6,450 51.7500 6,450 51.7500 333,788
2024-01-17 IONS O'NEIL PATRICK R. 7,744 50.4170 7,744 50.4170 390,429
2023-12-26 IONS O'NEIL PATRICK R. 20,825 51.4630 20,825 51.4630 1,071,717
2023-02-06 IONS O'NEIL PATRICK R. 1,920 40.8648 1,920 40.8648 78,460
2023-01-18 IONS O'NEIL PATRICK R. 7,836 39.4946 7,836 39.4946 309,480
2019-04-04 IONS O'NEIL PATRICK R. 1,122 82.0100 1,122 82.0100 92,015
2019-04-04 IONS O'NEIL PATRICK R. 1,878 84.2500 1,878 84.2500 158,222
2018-01-16 IONS O'NEIL PATRICK R. 2,697 51.7600 2,697 51.7600 139,597
2017-01-17 IONS O'NEIL PATRICK R. 122 46.2930 122 46.2930 5,648
2017-01-17 IONS O'NEIL PATRICK R. 256 46.2900 256 46.2900 11,850
2017-01-17 IONS O'NEIL PATRICK R. 733 46.2900 733 46.2900 33,931
2017-01-17 IONS O'NEIL PATRICK R. 512 46.2910 512 46.2910 23,701
2017-01-17 IONS O'NEIL PATRICK R. 623 46.2900 623 46.2900 28,839
2016-01-19 IONS O'NEIL PATRICK R. 216 41.4563 216 41.4563 8,955
2016-01-19 IONS O'NEIL PATRICK R. 125 41.4589 125 41.4589 5,182
2016-01-19 IONS O'NEIL PATRICK R. 261 41.4592 261 41.4592 10,821
2016-01-19 IONS O'NEIL PATRICK R. 747 41.4653 747 41.4653 30,975
2016-01-19 IONS O'NEIL PATRICK R. 522 41.4588 522 41.4588 21,641
2015-01-16 ISIS O'NEIL PATRICK R. 207 67.9640 207 67.9640 14,069
2015-01-16 ISIS O'NEIL PATRICK R. 120 67.9640 120 67.9640 8,156
2015-01-16 ISIS O'NEIL PATRICK R. 250 67.9640 250 67.9640 16,991
2015-01-16 ISIS O'NEIL PATRICK R. 714 67.9640 714 67.9640 48,526
2014-11-03 ISIS O'NEIL PATRICK R. 1,500 46.1700 1,500 46.1700 69,255
2014-01-16 ISIS O'NEIL PATRICK R. 250 47.0812 250 47.0812 11,770
2014-01-16 ISIS O'NEIL PATRICK R. 207 47.0810 207 47.0810 9,746
2014-01-16 ISIS O'NEIL PATRICK R. 120 47.0812 120 47.0812 5,650
2013-01-17 ISIS O'NEIL PATRICK R. 242 14.1600 242 14.1600 3,427

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Saham yang Disesuaikan adalah saham yang disesuaikan dengan pemisahan saham.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Sejarah Perdagangan Orang Dalam

Tabel ini menunjukkan daftar lengkap transaksi orang dalam yang dilakukan oleh O'neil Patrick R. sebagaimana diungkapkan kepada Komisi Bursa Efek (Securities Exchange Commission/SEC).

Tanggal File Tanggal Transaksi Formulir Ticker Keamanan Kode 10b5-1 Saham Sisa Saham Persen
Ubah
Bagikan
Harga
Tran
Nilai
Sisa
Nilai
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 49,800 57,130 679.40 53.77 2,677,746 3,071,880
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -11,375 7,330 -60.81 61.42 -698,652 450,209
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 13,050 18,705 230.77 32.60 425,430 609,783
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -65,475 5,655 -92.05 60.89 -3,986,773 344,333
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 14,000 71,130 24.51 37.58 526,120 2,673,065
2025-09-04 2025-09-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13,050 57,130 -18.60 54.51 -711,418 3,114,431
2025-09-04 2025-09-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 13,050 70,180 22.84 32.60 425,430 2,287,868
2025-09-03 2025-08-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 331 57,130 0.58 27.71 9,172 1,583,072
2025-03-04 2025-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 554 56,799 0.98 28.21 15,629 1,602,385
2025-02-24 2025-02-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,207 56,245 -2.10 32.35 -39,046 1,819,526
2025-02-06 2025-02-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,165 57,452 -9.69 31.62 -194,939 1,816,649
2025-02-03 2025-01-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,406 63,617 -2.16 32.49 -45,685 2,067,082
2025-02-03 2025-01-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
A - Award 3,820 65,023 6.24
2025-01-17 2025-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,360 61,203 -10.73 32.83 -241,629 2,009,294
2025-01-17 2025-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 19,690 68,563 40.29
2024-09-04 2024-02-02 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,995 48,627 -3.94 49.67 -99,099 2,415,488
2024-09-04 2024-08-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 246 48,873 0.51 38.64 9,506 1,888,502
2024-02-02 2024-02-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,961 48,661 -3.87 49.67 -97,410 2,417,177
2024-02-02 2024-02-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
A - Award 3,820 50,622 8.16
2024-01-29 2024-01-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,450 46,802 -12.11 51.75 -333,788 2,422,004
2024-01-18 2024-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,744 53,252 -12.70 50.42 -390,429 2,684,806
2024-01-18 2024-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 20,641 60,996 51.15
2023-12-28 2023-12-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -20,825 40,355 -34.04 51.46 -1,071,717 2,076,789
2023-12-28 2023-12-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 20,825 61,180 51.60 47.34 985,856 2,896,261
2023-05-24 2023-05-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,527 40,355 -3.65 41.70 -63,676 1,682,804
2023-03-02 2023-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 301 41,882 0.72 30.52 9,185 1,278,029
2023-02-07 2023-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,920 41,581 -4.41 40.86 -78,460 1,699,199
2023-02-07 2023-02-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
A - Award 3,822 43,501 9.63
2023-02-02 2023-01-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,500 39,679 -10.19 39.71 -178,700 1,575,697
2023-02-02 2023-01-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,500 44,179 -9.24 39.42 -177,372 1,741,359
2023-01-19 2023-01-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,836 48,679 -13.87 39.49 -309,480 1,922,558
2023-01-19 2023-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 21,871 56,515 63.13
2022-09-01 2022-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 108 34,644 0.31 28.97 3,129 1,003,567
2022-04-14 2022-04-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,792 34,536 -16.43 40.06 -272,057 1,383,357
2022-03-02 2022-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 735 41,328 1.81 28.37 20,854 1,172,599
2022-01-20 2022-01-18 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -21,086 52,319 -28.73
2022-01-20 2022-01-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -7,501 40,593 -15.60 30.12 -225,930 1,222,661
2022-01-20 2022-01-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 21,086 48,094 78.07
2022-01-19 2022-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
A - Award 15,284 73,405 26.30
2022-01-19 2022-01-15 4 IONS IONIS PHARMACEUTICALS INC
Performance Restricted Stock Units
A - Award 11,463 11,463
2022-01-05 2022-01-03 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
A - Award 30,567 30,567
2021-09-02 2021-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 309 27,008 1.16 33.80 10,443 912,762
2021-03-02 2021-02-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 197 26,699 0.74 44.54 8,774 1,189,173
2021-01-27 2021-01-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,324 26,502 -16.73 63.50 -338,074 1,682,877
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -16,504 32,253 -33.85
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 25,868 25,868
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -5,856 31,826 -15.54 61.28 -358,856 1,950,297
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 16,504 37,682 77.93
2021-01-06 2021-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 58,203 58,203
2020-09-02 2020-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 169 21,178 0.80 44.46 7,513 941,468
2020-03-03 2020-02-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 289 21,009 1.39 43.16 12,474 906,811
2020-02-11 2020-02-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,882 20,720 -15.78 59.60 -231,367 1,234,912
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -12,045 24,552 -32.91
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 24,205 24,205
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -4,277 24,602 -14.81 62.06 -265,431 1,526,800
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,045 28,879 71.55
2020-01-03 2020-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (Right to Buy)
A - Award 54,461 54,461
2019-07-02 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 161 16,834 0.97 45.70 7,358 769,390
2019-04-05 2019-04-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 2,252 7,969 39.39
2019-04-05 2019-04-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,252 16,673 -11.90 84.75 -190,857 1,413,037
2019-04-05 2019-04-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,252 18,925 13.51 61.68 138,903 1,167,294
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 8,000 46,638 20.71
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 5,600 20,825 36.78
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 2,657 0 -100.00
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 20,365 10,221 -200.76
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,878 16,673 -10.12 84.25 -158,222 1,404,700
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,122 18,551 -5.70 82.01 -92,015 1,521,368
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8,000 19,673 -28.91 84.29 -674,320 1,658,237
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8,000 27,673 40.66 49.25 394,000 1,362,895
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,600 19,673 -15.47 82.10 -295,560 1,615,153
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,600 23,273 18.30 47.34 170,424 1,101,744
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 19,673 -9.23 84.20 -168,400 1,656,467
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,000 21,673 10.17 47.34 94,680 1,026,000
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,657 19,673 -11.90 82.03 -217,954 1,613,776
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,657 22,330 13.51 61.57 163,591 1,374,858
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,873 19,673 -19.85 82.19 -400,512 1,616,924
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,873 24,546 24.77 61.68 300,567 1,513,997
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15,492 19,673 -44.06 84.75 -1,312,947 1,667,287
2019-04-05 2019-04-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15,492 35,165 78.75 61.68 955,547 2,168,977
2019-04-05 2019-04-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 7,654 30,586 33.38
2019-04-05 2019-04-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -7,654 19,673 -28.01 84.83 -649,289 1,668,861
2019-04-05 2019-04-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 7,654 27,327 38.91 61.68 472,099 1,685,529
2019-03-20 2019-03-18 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 28,800 2,657 -110.16
2019-03-20 2019-03-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -28,800 19,673 -59.41 78.79 -2,269,187 1,550,059
2019-03-20 2019-03-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 28,800 48,473 146.39 61.57 1,773,216 2,984,483
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 8,000 0 -100.00
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 18,800 4,755 -133.86
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8,000 19,673 -28.91 68.75 -550,000 1,352,519
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8,000 27,673 40.66 39.87 318,960 1,103,323
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -14,100 19,673 -41.75 68.75 -969,375 1,352,519
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 14,100 33,773 71.67 47.34 667,494 1,598,814
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,700 19,673 -19.28 64.51 -303,205 1,269,137
2019-03-01 2019-02-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,700 24,373 23.89 47.34 222,498 1,153,818
2019-02-14 2019-02-12 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 275 8,000 3.56
2019-02-14 2019-02-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -275 19,673 -1.38 59.50 -16,362 1,170,544
2019-02-14 2019-02-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 275 19,948 1.40 39.87 10,964 795,327
2019-02-05 2019-02-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 15,600 8,275 -212.97
2019-02-05 2019-02-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15,600 19,673 -44.23 59.50 -928,200 1,170,544
2019-02-05 2019-02-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15,600 35,273 79.30 39.87 621,972 1,406,335
2019-02-05 2019-02-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 4,000 23,875 20.13
2019-02-05 2019-02-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 19,673 -16.90 58.29 -233,160 1,146,739
2019-02-05 2019-02-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,000 23,673 20.33 39.87 159,480 943,843
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -7,823 14,466 -35.10
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 22,131 22,131
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -2,734 19,607 -12.24 58.26 -159,283 1,142,304
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,823 22,341 53.88
2019-01-03 2019-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4,000 27,875 -12.55
2019-01-03 2019-01-03 4 IONS IONIS PHARMACEUTICALS INC
Empoyee Stock Option (right to buy)
M - Exercise -400 0 -100.00
2019-01-03 2019-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 14,584 -21.52 54.80 -219,200 799,203
2019-01-03 2019-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,000 18,584 27.43 39.87 159,480 740,944
2019-01-03 2019-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -400 14,584 -2.67 54.80 -21,920 799,203
2019-01-03 2019-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 400 14,984 2.74 10.82 4,328 162,127
2019-01-03 2019-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 49,800 49,800
2019-01-03 2019-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 66 14,584 0.45 36.45 2,406 531,558
2018-07-03 2018-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 66 14,518 0.46 35.42 2,338 514,220
2018-03-13 2018-03-12 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 400 -71.43
2018-03-13 2018-03-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 14,452 -6.47 55.00 -55,000 794,860
2018-03-13 2018-03-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 15,452 6.92 10.82 10,820 167,191
2018-01-31 2018-01-29 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -300 1,400 -17.65
2018-01-31 2018-01-29 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -55 0 -100.00
2018-01-31 2018-01-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -300 14,452 -2.03 55.00 -16,500 794,860
2018-01-31 2018-01-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 300 14,752 2.08 10.82 3,246 159,617
2018-01-31 2018-01-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -55 14,452 -0.38 55.00 -3,025 794,860
2018-01-31 2018-01-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 55 14,507 0.38 10.82 595 156,966
2018-01-29 2018-01-25 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -645 55 -92.14
2018-01-29 2018-01-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -645 14,452 -4.27 55.00 -35,475 794,860
2018-01-29 2018-01-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 645 15,097 4.46 10.82 6,979 163,350
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -2,697 14,452 -15.73 51.76 -139,597 748,036
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -6,663 10,148 -39.63
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 12,141 12,141
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 6,663 17,149 63.54
2018-01-02 2018-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 54,638 54,638
2018-01-02 2018-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 53 10,486 0.51 42.76 2,266 448,329
2017-12-01 2017-12-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 700 -58.82
2017-12-01 2017-12-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 10,433 -8.75 55.50 -55,500 579,032
2017-12-01 2017-12-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 11,433 9.58 10.82 10,820 123,705
2017-11-03 2017-11-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 1,700 -37.04
2017-11-03 2017-11-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 10,433 -8.75 58.35 -58,350 608,766
2017-11-03 2017-11-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 11,433 9.58 10.82 10,820 123,705
2017-10-06 2017-10-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -800 2,700 -22.86
2017-10-06 2017-10-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -200 0 -100.00
2017-10-06 2017-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 10,433 -7.12 55.00 -44,000 573,815
2017-10-06 2017-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 11,233 7.67 10.82 8,656 121,541
2017-10-06 2017-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 10,433 -1.88 55.00 -11,000 573,815
2017-10-06 2017-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 10,633 1.92 7.25 1,450 77,089
2017-09-07 2017-09-06 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -800 200 -80.00
2017-09-07 2017-09-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 10,433 -7.12 55.00 -44,000 573,815
2017-09-07 2017-09-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 11,233 7.67 7.25 5,800 81,439
2017-09-07 2017-09-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -200 1,000 -16.67
2017-09-07 2017-09-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 10,433 -1.88 55.00 -11,000 573,815
2017-09-07 2017-09-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 10,633 1.92 7.25 1,450 77,089
2017-07-03 2017-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 134 10,433 1.30 40.66 5,448 424,159
2017-06-02 2017-06-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -70 1,700 -3.95
2017-06-02 2017-06-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -70 10,299 -0.68 48.00 -3,360 494,352
2017-06-02 2017-06-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 70 10,369 0.68 10.82 757 112,193
2017-05-03 2017-05-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 1,770 -22.03
2017-05-03 2017-05-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 10,299 -4.63 48.75 -24,375 502,076
2017-05-03 2017-05-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 10,799 4.85 10.82 5,410 116,845
2017-05-03 2017-05-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -150 10,299 -1.44 48.75 -7,312 502,076
2017-04-26 2017-04-24 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -426 3,500 -10.85
2017-04-26 2017-04-24 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -74 2,270 -3.16
2017-04-26 2017-04-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -426 10,449 -3.92 45.00 -19,170 470,205
2017-04-26 2017-04-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 426 10,875 4.08 10.82 4,609 117,668
2017-04-26 2017-04-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -74 10,449 -0.70 45.00 -3,330 470,205
2017-04-26 2017-04-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 74 10,523 0.71 10.82 801 113,859
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 10,449 -8.73 40.07 -40,070 418,691
2017-03-02 2017-03-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 3,926 -11.30
2017-03-02 2017-03-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 11,449 -8.03 49.29 -49,290 564,321
2017-03-02 2017-03-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 12,449 -3.86 49.29 -24,645 613,611
2017-03-02 2017-03-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 12,949 4.02 10.82 5,410 140,108
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -481 4,426 -9.80
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -19 1,200 -1.56
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -481 12,449 -3.72 46.50 -22,366 578,878
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 481 12,930 3.86 10.82 5,204 139,903
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -19 12,449 -0.15 46.50 -884 578,878
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 19 12,468 0.15 7.25 138 90,393
2017-02-08 2017-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,449 -7.44 46.00 -46,004 572,704
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -623 13,449 -4.43 46.29 -28,839 622,554
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -512 12,478 -3.94 46.29 -23,701 577,619
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -733 11,679 -5.91 46.29 -33,931 540,621
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -256 10,537 -2.37 46.29 -11,850 487,758
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -122 10,140 -1.19 46.29 -5,648 469,411
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,594 4,779 -25.01
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,311 2,620 -33.35
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,875 1,875 -50.00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -653 0 -100.00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -312 0 -100.00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 7,537 7,537
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,594 14,072 12.77
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,311 12,990 11.23
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,875 12,412 17.79
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 653 10,793 6.44
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 312 10,262 3.14
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 45,225 45,225
2017-01-04 2017-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 424 9,950 4.45 20.76 8,801 206,532
2016-12-07 2016-12-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -350 2,344 -12.99
2016-12-07 2016-12-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -350 9,526 -3.54 45.00 -15,750 428,670
2016-12-07 2016-12-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 350 9,876 3.67 10.82 3,787 106,858
2016-11-14 2016-11-14 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -806 2,694 -23.03
2016-11-14 2016-11-14 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -194 4,907 -3.80
2016-11-14 2016-11-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -806 9,526 -7.80 45.00 -36,270 428,670
2016-11-14 2016-11-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 806 10,332 8.46 10.82 8,721 111,792
2016-11-14 2016-11-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -194 9,526 -2.00 45.00 -8,730 428,670
2016-11-14 2016-11-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 194 9,720 2.04 10.82 2,099 105,170
2016-07-01 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 402 9,526 4.41 20.76 8,344 197,731
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 5,101 -16.39
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 9,124 -9.88 45.00 -45,000 410,580
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 10,124 10.96 10.82 10,820 109,542
2016-03-24 2016-03-23 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 6,101 -14.08
2016-03-24 2016-03-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 9,124 -9.88 45.40 -45,400 414,230
2016-03-24 2016-03-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 10,124 10.96 10.82 10,820 109,542
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -522 9,124 -5.41 41.46 -21,641 378,270
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -747 8,335 -8.23 41.47 -30,975 345,613
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -261 7,207 -3.49 41.46 -10,821 298,796
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -125 6,814 -1.80 41.46 -5,182 282,501
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -216 6,627 -3.16 41.46 -8,955 274,731
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,311 3,931 -25.01
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,875 3,750 -33.33
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -654 653 -50.04
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -312 312 -50.00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -541 0 -100.00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 6,373 6,373
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,311 9,646 15.73
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,875 9,082 26.02
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 654 7,468 9.60
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 312 6,939 4.71
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 541 6,843 8.58
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -848 1,219 -41.03
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -152 7,101 -2.10
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 38,240 38,240
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -848 6,302 -11.86 61.10 -51,813 385,052
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 848 7,150 13.46 7.25 6,148 51,838
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -152 6,302 -2.36 61.10 -9,287 385,052
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 152 6,454 2.41 10.82 1,645 69,832
2016-01-04 2016-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 43 6,302 0.69 47.71 2,052 300,672
2015-12-02 2015-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 2,067 -32.61
2015-12-02 2015-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 6,259 -13.78 61.50 -61,500 384,928
2015-12-02 2015-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 7,259 15.98 7.25 7,250 52,628
2015-11-04 2015-11-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 3,067 -24.59
2015-11-04 2015-11-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 6,259 -13.78 51.95 -51,950 325,155
2015-11-04 2015-11-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 7,259 15.98 7.25 7,250 52,628
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 85 6,259 1.38 48.59 4,130 304,100
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -13,125 31,875 -29.17
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4,000 3,500 -53.33
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6,100 7,253 -45.68
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,683 4,067 -58.29
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,617 0 -100.00
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,525 6,174 -63.03 75.00 -789,417 463,075
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10,525 16,699 170.47 39.87 419,632 665,789
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,600 6,174 -29.63 74.77 -194,394 461,611
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,600 8,774 42.11 39.87 103,662 349,819
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 6,174 -39.32 74.77 -299,068 461,611
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,000 10,174 64.79 10.82 43,280 110,083
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,100 6,174 -49.70 74.77 -456,079 461,611
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,100 12,274 98.80 10.82 66,002 132,805
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,683 6,174 -47.93 74.77 -424,901 461,611
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,683 11,857 92.05 7.25 41,202 85,963
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,617 6,174 -20.75 74.77 -120,898 461,611
2015-03-20 2015-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,617 7,791 26.19 10.29 16,639 80,169
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4,133 1,617 -71.88
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,667 0 -100.00
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,133 6,174 -40.10 71.67 -296,204 442,478
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,133 10,307 66.94 10.29 42,529 106,059
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,667 6,174 -21.26 71.67 -119,471 442,478
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,667 7,841 27.00 8.00 13,336 62,728
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -714 6,174 -10.37 67.96 -48,526 419,610
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -250 5,013 -4.75 67.96 -16,991 340,704
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -120 4,609 -2.54 67.96 -8,156 313,246
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -207 4,416 -4.48 67.96 -14,069 300,129
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,875 5,625 -25.00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -654 1,307 -33.35
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -313 624 -33.40
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -541 541 -50.00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5,242 5,242
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,875 6,888 37.40
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 654 5,263 14.19
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 313 4,729 7.09
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 541 4,623 13.25
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -283 9,750 -2.82
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,217 13,353 -8.35
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 31,457 31,457
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -283 4,082 -6.48 62.12 -17,579 253,553
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 283 4,365 6.93 7.25 2,052 31,646
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,217 4,082 -22.97 62.12 -75,594 253,553
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,217 5,299 29.81 10.82 13,168 57,335
2015-01-05 2015-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 329 4,082 8.77 30.05 9,886 122,654
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,500 10,033 -13.01
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3,753 -11.76 50.37 -25,185 189,039
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 4,253 13.32 7.25 3,625 30,834
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 4,253 13.32 7.25 3,625 30,834
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 4,253 13.32 7.25 3,625 30,834
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3,753 -11.76 51.05 -25,525 191,591
2014-12-03 2014-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3,753 -11.76 52.21 -26,105 195,944
2014-11-05 2014-11-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,500 11,533 -11.51
2014-11-05 2014-11-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,500 3,753 -28.56 46.17 -69,255 173,276
2014-11-05 2014-11-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,500 5,253 39.97 7.25 10,875 38,084
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,267 13,033 -8.86
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -233 5,750 -3.89
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 3,753 -17.57 37.90 -30,320 142,239
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 4,553 21.32 7.25 5,800 33,009
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -467 3,753 -11.07 38.20 -17,839 143,365
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 467 4,220 12.44 7.25 3,386 30,595
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -233 3,753 -5.85 38.20 -8,901 143,365
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 233 3,986 6.21 10.29 2,398 41,016
2014-09-04 2014-09-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,500 5,983 -20.05
2014-09-04 2014-09-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -700 3,753 -15.72 40.60 -28,420 152,372
2014-09-04 2014-09-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 700 4,453 18.65 10.29 7,203 45,821
2014-09-04 2014-09-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 3,753 -17.57 40.30 -32,240 151,246
2014-09-04 2014-09-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 4,553 21.32 10.29 8,232 46,850
2014-08-12 2014-08-12 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -800 7,483 -9.66
2014-08-12 2014-08-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 3,753 -17.57 35.00 -28,000 131,355
2014-08-12 2014-08-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 4,553 21.32 10.29 8,232 46,850
2014-08-12 2014-08-11 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -700 8,983 -7.23
2014-08-12 2014-08-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -700 3,753 -15.72 35.00 -24,500 131,355
2014-08-12 2014-08-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 700 4,453 18.65 10.29 7,203 45,821
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,500 8,983 -14.31
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,500 3,753 -28.56 35.33 -53,000 132,606
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,500 5,253 39.97 10.29 15,435 54,053
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 403 3,753 12.03 30.20 12,171 113,342
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -667 10,483 -5.98
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -33 1,667 -1.94
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -67 3,350 -1.96 35.27 -2,363 118,154
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 67 3,417 2.00 10.29 689 35,161
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -100 3,350 -2.90 35.28 -3,528 118,171
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 100 3,450 2.99 10.29 1,029 35,500
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 3,350 -5.63 35.29 -7,058 118,222
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 3,550 5.97 10.29 2,058 36,530
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -300 3,350 -8.22 35.45 -10,635 118,758
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 300 3,650 8.96 10.29 3,087 37,558
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -33 3,350 -0.98 35.27 -1,164 118,154
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 33 3,383 0.99 8.00 264 27,064
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -800 1,700 -32.00
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -100 3,350 -2.90 35.27 -3,527 118,154
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 100 3,450 2.99 8.00 800 27,600
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 100 3,450 2.99 8.00 800 27,600
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -100 3,350 -2.90 35.25 -3,525 118,096
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -400 3,350 -10.67 35.02 -14,008 117,317
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 400 3,750 11.94 8.00 3,200 30,000
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 3,350 -5.63 35.25 -7,050 118,088
2014-06-18 2014-06-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 3,550 5.97 8.00 1,600 28,400
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,500 1,458 -50.71
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3,350 -12.99 44.02 -22,010 147,467
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3,850 14.93 8.00 4,000 30,800
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3,850 14.93 8.00 4,000 30,800
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3,850 14.93 8.00 4,000 30,800
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3,350 -12.99 44.30 -22,150 148,405
2014-04-03 2014-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3,350 -12.99 44.88 -22,440 150,348
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,130 14,570 -7.20
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -370 0 -100.00
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 3,350 -19.28 50.70 -40,560 169,845
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 4,150 23.88 10.82 8,656 44,903
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -330 3,350 -8.97 49.20 -16,236 164,820
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 330 3,680 9.85 10.82 3,571 39,818
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -370 3,350 -9.95 49.20 -18,204 164,820
2014-03-05 2014-03-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 370 3,720 11.04 11.27 4,170 41,924
2014-02-05 2014-02-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,500 370 -80.21
2014-02-05 2014-02-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,500 3,350 -30.93 50.45 -75,676 169,011
2014-02-05 2014-02-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,500 4,850 44.78 11.27 16,905 54,660
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -120 3,350 -3.46 47.08 -5,650 157,722
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -207 3,157 -6.15 47.08 -9,746 148,635
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -250 2,822 -8.14 47.08 -11,770 132,863
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -313 937 -25.04
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -542 1,082 -33.37
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -654 1,961 -25.01
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 7,500 7,500
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 313 3,470 9.91
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 542 3,364 19.21
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 654 3,072 27.05
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 45,000 45,000
2014-01-03 2014-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 395 2,418 19.53 24.20 9,559 58,514
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10 0 -100.00
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise -10 0 -100.00
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2,480 1,870 -57.01
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10 2,023 -0.49 26.85 -268 54,318
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10 2,023 -0.49 26.85 -268 54,318
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10 2,033 0.49 14.47 145 29,418
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10 2,033 0.49 14.18 142 28,828
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -637 2,023 -23.95 26.85 -17,103 54,318
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 637 2,660 31.49 11.27 7,179 29,978
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -526 2,023 -20.64 27.00 -14,202 54,621
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 526 2,549 26.00 11.27 5,928 28,727
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,317 2,023 -39.43 27.25 -35,888 55,127
2013-09-06 2013-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,317 3,340 65.10 11.27 14,843 37,642
2013-07-05 2013-07-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -277 2,023 -12.04 29.25 -8,102 59,173
2013-07-05 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 976 2,300 73.72 9.20 8,976 21,153
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -3,900 11,150 -25.91
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,800 4,000 -31.03
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2,700 4,350 -38.30
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2,260 10 -99.56
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10,660 10 -99.91
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6,000 0 -100.00
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,900 1,324 -74.66 22.13 -86,307 29,300
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,900 5,224 294.56 10.29 40,131 53,755
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,800 1,324 -57.62 22.13 -39,834 29,300
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,800 3,124 135.95 8.00 14,400 24,992
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,700 1,324 -67.10 22.13 -59,751 29,300
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,700 4,024 203.93 11.27 30,429 45,350
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,260 1,324 -63.06 22.13 -50,014 29,300
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,260 3,584 170.69 14.47 32,702 51,860
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,660 1,324 -88.95 22.13 -235,906 29,300
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10,660 11,984 805.14 14.18 151,159 169,933
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,000 1,324 -81.92 22.13 -132,780 29,300
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,000 7,324 453.17 15.38 92,280 112,643
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6,000 2,270 -72.55
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 10,670 -8.57
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -8,000 6,000 -57.14
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 1,324 -79.06 21.01 -105,050 27,817
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 6,324 377.64 15.38 76,900 97,263
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,000 1,324 -81.92 20.01 -120,036 26,488
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,000 7,324 453.17 14.47 86,820 105,978
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 1,324 -43.03 19.60 -19,600 25,950
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 2,324 75.53 14.18 14,180 32,954
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 1,324 -69.38 20.25 -60,750 26,811
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 4,324 226.59 15.38 46,140 66,503
2013-04-15 2013-04-12 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4,330 11,670 -27.06
2013-04-15 2013-04-12 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,130 8,270 -12.02
2013-04-15 2013-04-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,330 1,324 -76.58 19.62 -84,948 25,975
2013-04-15 2013-04-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,330 5,654 327.04 14.18 61,399 80,174
2013-04-15 2013-04-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,130 1,324 -46.05 19.60 -22,148 25,950
2013-04-15 2013-04-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,130 2,454 85.35 14.47 16,351 35,509
2013-03-22 2013-03-21 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -9,000 16,000 -36.00
2013-03-22 2013-03-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -9,000 1,324 -87.18 19.26 -173,340 25,500
2013-03-22 2013-03-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 9,000 10,324 679.76 14.18 127,620 146,394
2013-03-04 2013-03-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,350 0 -100.00
2013-03-04 2013-03-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10,351 7,050 -59.49
2013-03-04 2013-03-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,350 1,324 -50.49 15.82 -21,353 20,942
2013-03-04 2013-03-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,350 2,674 101.96 11.12 15,012 29,735
2013-03-04 2013-03-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,350 1,324 -88.66 15.82 -163,706 20,942
2013-03-04 2013-03-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10,350 11,674 781.72 11.27 116,644 131,566
2013-02-20 2013-02-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,600 15,050 -9.61
2013-02-20 2013-02-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,600 1,324 -54.72 14.80 -23,680 19,595
2013-02-20 2013-02-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,600 2,924 120.85 10.29 16,464 30,088
2013-02-20 2013-02-15 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -250 16,650 -1.48
2013-02-20 2013-02-15 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -100 16,900 -0.59
2013-02-20 2013-02-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -250 1,324 -15.88 14.82 -3,705 19,622
2013-02-20 2013-02-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 250 1,574 18.88 10.29 2,572 16,196
2013-02-20 2013-02-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -100 1,324 -7.02 14.80 -1,480 19,595
2013-02-20 2013-02-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 100 1,424 7.55 10.29 1,029 14,653
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,200 14,300 -26.67
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -900 5,800 -13.43
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -139 1,324 -9.50 14.17 -1,970 18,761
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,200 1,463 -78.04 14.17 -73,684 20,731
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,200 6,663 355.43 7.25 37,700 48,307
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 1,463 -38.09 14.17 -12,753 20,731
2013-02-14 2013-02-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 2,363 61.52 8.00 7,200 18,904
2013-01-31 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2,000 17,000 -10.53
2013-01-31 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 1,463 -57.75 14.82 -29,640 21,682
2013-01-31 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,000 3,463 136.71 10.29 20,580 35,634
2013-01-31 2013-01-29 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -300 1,463 -17.02 13.40 -4,020 19,604
2013-01-17 2013-01-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -242 1,763 -12.07 14.16 -3,427 24,964
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,615 2,615
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1,250 1,250
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -542 1,624 -25.02
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 542 2,005 37.05
2013-01-04 2013-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,296 1,463 -46.97 10.76 -13,945 15,742
2013-01-03 2013-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 15,700 15,700
2013-01-03 2013-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 7,500 7,500
2013-01-03 2013-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 431 2,759 18.51 8.87 3,825 24,483
2013-01-03 3 ISIS ISIS PHARMACEUTICALS INC
Common Stock
2,328
P
Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.
S
Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.
A
Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)
C
Konversi turunan
D
Penjualan atau pengalihan sekuritas kembali ke perusahaan.
F
Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.
G
Pemberian sekuritas oleh atau kepada orang dalam.
K
Swap ekuitas dan transaksi lindung nilai serupa
M
Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)
V
Transaksi yang dilaporkan secara sukarela pada Formulir 4.
J
Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)