EPRSQ / Epirus Biopharmaceuticals Inc - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Epirus Biopharmaceuticals Inc
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HINDI NA ACTIVE ANG SIMBONG ITO

Mga Batayang Estadistika
LEI 549300B6OBAWAZGW2N50
CIK 1135906
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Epirus Biopharmaceuticals Inc
SEC Filings (Chronological Order)
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February 14, 2017 EX-1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT This Joint Filing Agreement dated February 14, 2017 is by and between Camber Capital Management LLC, a Massachusetts limited liability company, and Stephen DuBois, an individual (the foregoing are collectively referred to herein as the "Filers").

February 14, 2017 SC 13G/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / Camber Capital Management LLC - PRIMARY DOCUMENT Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3) EPIRUS Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 29428P107 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

August 1, 2016 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 000-51171 04-3514457 (State or other jurisdiction of incorporation) (Comm

July 25, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Other Events, Bankruptcy or Receivership

8-K 1 a16-1520118k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 13, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 000-51171 04-3514457 (State or other jurisdict

July 11, 2016 SC 13G/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / PRUDENTIAL FINANCIAL INC Passive Investment

SC 13G/A 1 epir.htm DOCUMENT TYPE SC 13G/A TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment # 2 Name of Issuer: EPIRUS Biopharmaceuticals, Inc. Title of Class of Securities: Common Stock CUSIP Number: 29428P107 1) NAME AND I.R.S. IDENTIFICATION NO. OF REPORTING PERSON Prudential Financial, Inc. 22-3703799 2.) MEMBER OF

July 1, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Completion of Acquisition or Disposition of Assets, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 000-51171 04-3514457 (State or other jurisdiction of incorporation) (Comm

June 14, 2016 8-K

Entry into a Material Definitive Agreement, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 10, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 000-51171 04-3514457 (State or other jurisdiction of incorporation) (Comm

May 10, 2016 10-Q

EPIRUS Biopharmaceuticals 10-Q (Quarterly Report)

eprsCurrentFolio10Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 9, 2016 EX-99.1

EPIRUS Announces Reprioritization of Pipeline to Solely Focus on Biosimilars to Treat Rare Diseases and Key Leadership Changes

Exhibit 99.1 EPIRUS Announces Reprioritization of Pipeline to Solely Focus on Biosimilars to Treat Rare Diseases and Key Leadership Changes ? New strategy to focus exclusively on BOW080 (eculizumab biosimilar) and BOW070 (tocilizumab biosimilar) in rare diseases with a combined target market opportunity of close to $6 billion of innovator sales estimated in 2020 ? Amit Munshi steps down as preside

May 9, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Costs Associated with Exit or Disposal Activities, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 000-51171 04-3514457 (State or other jurisdiction of incorporation) (Commis

April 29, 2016 10-K/A

EPIRUS Biopharmaceuticals 10-K/A (Annual Report)

10-K/A 1 a16-9302110ka.htm 10-K/A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A (Amendment No. 1) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2015 ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition perio

March 29, 2016 S-8

EPIRUS Biopharmaceuticals S-8

As filed with the Securities and Exchange Commission on March 29, 2016 Registration No.

March 29, 2016 EX-10.25

Employment Agreement

Exhibit 10.25 Employment Agreement between Epirus Biopharmaceuticals (Switzerland) GmbH. General-Guisan-Strasse 6, 6303 Zug "Employer" and Vincent Aurentz [address redacted] "Employee" collectively, the "Parties" and each individually, a "Party" 2 / 10 Employment Agreement Epirus Biopharmaceuticals (Switzerland) GmbH / Vince Aurentz The Parties hereby agree on the terms and conditions of the Emplo

March 29, 2016 EX-10.16

EPIRUS BIOPHARMACEUTICALS, INC. AMENDED AND RESTATED Non-Employee DIRECTOR COMPENSATION POLICY

Exhibit 10.16 EPIRUS BIOPHARMACEUTICALS, INC. AMENDED AND RESTATED Non-Employee DIRECTOR COMPENSATION POLICY Non-employee members of the board of directors (the “Board”) of EPIRUS Biopharmaceuticals, Inc. (the “Company”) shall be eligible to receive cash and equity compensation as set forth in this Amended and Restated Non-Employee Director Compensation Policy (this “Policy”). The cash and equity

March 29, 2016 EX-21.1

Subsidiaries of EPIRUS Biopharmaceuticals, Inc.

Exhibit 21.1 Subsidiaries of EPIRUS Biopharmaceuticals, Inc. Name of Wholly-Owned Subsidiary Jurisdiction of Organization EB Sub, Inc. Delaware Epirus Biopharmaceuticals Ltd. United Kingdom Epirus Biopharmaceuticals (Switzerland) GmbH Switzerland Epirus Brasil Tecnologia Ltda Brazil Epirus Biopharmaceuticals (Netherlands) B.V. Netherlands

March 29, 2016 EX-10.36

EPIRUS BIOPHARMACEUTICALS, INC. As Vendor - and - TARO PHARMACEUTICALS INC. As Purchaser - Regarding – ZALICUS PHARMACEUTICALS LTD. SHARE PURCHASE AGREEMENT OCTOBER 1, 2015

Exhibit 10.36 Execution Copy EPIRUS BIOPHARMACEUTICALS, INC. As Vendor - and - TARO PHARMACEUTICALS INC. As Purchaser - Regarding – ZALICUS PHARMACEUTICALS LTD. SHARE PURCHASE AGREEMENT OCTOBER 1, 2015 TABLE OF CONTENTS Article 1 INTERPRETATION 1 1.1 Definitions 1 1.2 Construction 10 1.3 Certain Rules of Interpretation 10 1.4 Knowledge 11 1.5 Computation of Time 11 1.6 Performance on Business Days

March 29, 2016 EX-10.8

Incentive Stock Option Granted Under the 2015 Equity Incentive Plan of EPIRUS Biopharmaceuticals, Inc.

Exhibit 10.8 EPIRUS BIOPHARMACEUTICALS, INC ID: 04-3514457 699 Boylston St 8th Floor Boston, MA 02116 Notice of Grant of Stock Options and Option Agreement <> Option Number: <> < > Plan: 2015 Effective <>, you have been granted a(n) Incentive Stock Option to buy <> shares of EPIRUS BIOPHARMACEUTICALS, INC (the Company) stock at $<> per share. The total option price of the shares granted is $<>. Sh

March 29, 2016 EX-10.9

Nonstatutory Stock Option Granted Under the 2015 Equity Incentive Plan of EPIRUS Biopharmaceuticals, Inc.

Exhibit 10.9 EPIRUS BIOPHARMACEUTICALS, INC ID: 04-3514457 699 Boylston St 8th Floor Boston, MA 02116 Notice of Grant of Stock Options and Option Agreement <> Option Number: <> < > Plan: 2015 Effective <>, you have been granted a(n) Non-Qualified Stock Option to buy <> shares of EPIRUS BIOPHARMACEUTICALS, INC (the Company) stock at $<> per share. The total option price of the shares granted is $<>

March 29, 2016 EX-10.10

Granted Under the 2015 Equity Incentive Plan of EPIRUS Biopharmaceuticals, Inc.

eprs_EX_10_10 Exhibit 10.10 EPIRUS BIOPHARMACEUTICALS, INC ID: 04-3514457 699 Boylston St 8th Floor Boston, MA 02116 Notice of Grant of Award and Award Agreement <> Award Number: <> < > Plan: 2015 Effective <>, you have been granted an award of <> restricted stock units. These units are restricted until the vest date(s) shown below, at which time you will receive shares of EPIRUS BIOPHARMACEUTICAL

March 28, 2016 10-K

EPIRUS Biopharmaceuticals 10-K (Annual Report)

eprsCurrentFolio10K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 15, 2016 NT 10-K

EPIRUS Biopharmaceuticals NT 10-K

NT 10-K 1 a16-63951nt10k.htm NT 10-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): x Form 10-K o Form 20-F o Form 11-K o Form 10-Q o Form 10-D o Form N-SAR o Form N-CSR For Period Ended: December 31, 2015 o Transition Report on Form 10-K o Transition Report on Form 20-F o Transition Report on Form 11-K o Transition Repo

March 15, 2016 EX-99.1

EPIRUS Biopharmaceuticals Reports Fourth Quarter and Fiscal Year 2015 Financial Results and Provides Business Update Substantial Progress Made During 2015 Advancing Six Biosimilar Assets, with Global Filings Targeted Every Year from 2017 through 2022

Exhibit 99.1 EPIRUS Biopharmaceuticals Reports Fourth Quarter and Fiscal Year 2015 Financial Results and Provides Business Update Substantial Progress Made During 2015 Advancing Six Biosimilar Assets, with Global Filings Targeted Every Year from 2017 through 2022 Boston, MA ? (GlobeNewswire) ? March 15, 2016 ? EPIRUS Biopharmaceuticals, Inc. (Nasdaq: EPRS), a pure-play biosimilar company focused o

March 15, 2016 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 15, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (Com

March 1, 2016 424B5

$30,000,000 of Shares Common Stock

424B5 1 a2227424z424b5.htm 424B5 QuickLinks - Click here to rapidly navigate through this document Filed Pursuant to Rule 424(b)(5) Registration No. 333- 205420 PROSPECTUS SUPPLEMENT (To prospectus dated July 17, 2015) $30,000,000 of Shares Common Stock This prospectus supplement and accompanying prospectus relate to the issuance and sale of up to $30,000,000 of shares of our common stock, par val

March 1, 2016 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 29, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (

March 1, 2016 EX-1.1

EPIRUS BIOPHARMACEUTICALS, INC. UP TO $30,000,000 OF COMMON STOCK (par value $0.001 per share) AT-THE-MARKET SALES AGREEMENT

Exhibit 1.1 EPIRUS BIOPHARMACEUTICALS, INC. UP TO $30,000,000 OF COMMON STOCK (par value $0.001 per share) AT-THE-MARKET SALES AGREEMENT February 29, 2016 BTIG, LLC 825 Third Avenue, 6th Floor New York, NY 10022 Ladies and Gentlemen: EPIRUS Biopharmaceuticals, Inc., a Delaware corporation (the ?Company?), confirms its agreement (this ?Agreement?) with BTIG, LLC (?BTIG? and, together with the Compa

February 12, 2016 SC 13G/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / Camber Capital Management LLC Passive Investment

SC 13G/A 1 camberepirus201513gv3.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) EPIRUS Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 29428P107 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing of this Statement) Check the

February 12, 2016 SC 13G/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / Broadfin Capital, LLC Passive Investment

SC 13G/A 1 d7034935sc13g-a1.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Epirus Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 29428P107 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing of this Statement) Chec

February 12, 2016 EX-1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT This Joint Filing Agreement dated February 12, 2016 is by and between Camber Capital Management LLC, a Massachusetts limited liability company, and Stephen DuBois, an individual (the foregoing are collectively referred to herein as the "Filers").

February 9, 2016 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a15-2369428k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 9, 2016 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisd

February 9, 2016 EX-99.1

EPIRUS Biopharmaceuticals Initiates Pivotal Global Phase 3 Clinical Study for BOW015 (Infliximab Biosimilar)

Exhibit 99.1 EPIRUS Biopharmaceuticals Initiates Pivotal Global Phase 3 Clinical Study for BOW015 (Infliximab Biosimilar) ? UNIFORM(i) Study builds on prior successful Phase 1 and Phase 3 studies ? Intended to support harmonized global filing for BOW015 in 2017 ? BOW015 is a biosimilar for Remicade?, which had global sales of $8.8 billion in 2014 Boston, MA ? (GlobeNewswire) ? February 09, 2016 ?

January 28, 2016 SC 13G/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / PRUDENTIAL FINANCIAL INC Passive Investment

SC 13G/A 1 epir.htm DOCUMENT TYPE SC 13G/A TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment # 1 Name of Issuer: EPIRUS Biopharmaceuticals, Inc. Title of Class of Securities: Common Stock CUSIP Number: 29428P107 1) NAME AND I.R.S. IDENTIFICATION NO. OF REPORTING PERSON Prudential Financial, Inc. 22-3703799 2.) MEMBER OF

November 16, 2015 EX-99.1

EPIRUS Biopharmaceuticals Reports Third Quarter 2015 Financial Results & Provides Business Update Multiple Biosimilar Product Filings for Marketing Approval in 2015 and Global Filings Anticipated Each Year from 2017 through 2022

Exhibit 99.1 EPIRUS Biopharmaceuticals Reports Third Quarter 2015 Financial Results & Provides Business Update Multiple Biosimilar Product Filings for Marketing Approval in 2015 and Global Filings Anticipated Each Year from 2017 through 2022 Boston, MA ? (GlobeNewswire) ? November 16, 2015 ? EPIRUS Biopharmaceuticals, Inc. (Nasdaq: EPRS), a biopharmaceutical company focused on the global developme

November 16, 2015 EX-10.3

New Collaboration Compound Supplement to the Collaboration Agreement by and between EPIRUS SWITZERLAND GmbH LIVZON MABPHARM INC.

Exhibit 10.3 New Collaboration Compound Supplement to the Collaboration Agreement by and between EPIRUS SWITZERLAND GmbH and LIVZON MABPHARM INC. This New Collaboration Compound Supplement (this ?Supplement?), dated as of September 24th , 2015 (the ?Supplement Effective Date?), to the Collaboration Agreement (as defined below), by and between EPIRUS SWITZERLAND GmbH, a Swiss corporation, having it

November 16, 2015 EX-99.1

Bioceros Holding B.V. Financial Statements Independent Auditors’ Report December 31, 2014 Unaudited Financial Statements As of June 30, 2015 and for the Six Months Ended June 30, 2015 and 2014 Utrecht, The Netherlands (Registered office and actual pl

Exhibit 99.1 Bioceros Holding B.V. Financial Statements and Independent Auditors? Report December 31, 2014 and Unaudited Financial Statements As of June 30, 2015 and for the Six Months Ended June 30, 2015 and 2014 Utrecht, The Netherlands (Registered office and actual place of business) 1 Index Page Independent auditor?s report 3 Consolidated financial statements Consolidated Balance Sheets 4 Cons

November 16, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 16, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (

November 16, 2015 8-K/A

Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

8-K/A 1 a15-2241138ka.htm 8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A Amendment No. 1 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 9, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-351445

November 16, 2015 EX-99.2

EPIRUS Biopharmaceuticals Provides Clinical Program Update on BOW015 (Infliximab Biosimilar)

EX-99.2 3 a15-224112ex99d2.htm EX-99.2 Exhibit 99.2 EPIRUS Biopharmaceuticals Provides Clinical Program Update on BOW015 (Infliximab Biosimilar) · Readiness for on-time initiation of pivotal global registration study with completion of manufacturing process lock · BOW015 remains on track for 2017 global filing · BOW015 targets large market opportunity based on $8.8 billion global sales of Remicade

November 16, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ?QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2015. Or ?TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-5117

November 16, 2015 EX-10.1

COLLABORATION AGREEMENT BY AND BETWEEN EPIRUS SWITZERLAND GMBH SWISS PHARMA INTERNATIONAL AG JULY 13, 2015

Exhibit 10.1 EXECUTION VERSION COLLABORATION AGREEMENT BY AND BETWEEN EPIRUS SWITZERLAND GMBH AND SWISS PHARMA INTERNATIONAL AG JULY 13, 2015 Portions of this Exhibit, indicated by the mark ?[***],? were omitted and have been filed separately with the Securities and Exchange Commission pursuant to the Registrant?s application requesting confidential treatment pursuant to Rule 24b-2 of the Securiti

November 16, 2015 EX-99.2

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Exhibit 99.2 Unaudited Pro Forma Condensed Combined Financial Information at June 30, 2015 and for the six months ended June 30, 2015 and the year ended December 31, 2014. UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION On September 9, 2015, EPIRUS Biopharmaceuticals, Inc. (?Epirus?, ?Company?, ?we?, ?our?, or ?us?), completed the acquisition of Bioceros Holding B.V. (?Bioceros?). The

November 10, 2015 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a15-2241118k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 10, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Juris

November 10, 2015 EX-99.1

EPIRUS Biopharmaceuticals Appoints Industry Veteran Vincent E. Aurentz as Chief Business Officer

Exhibit 99.1 EPIRUS Biopharmaceuticals Appoints Industry Veteran Vincent E. Aurentz as Chief Business Officer Boston, MA ? (GlobeNewswire) ? November 10, 2015 ? EPIRUS Biopharmaceuticals, Inc. (Nasdaq:EPRS), a biopharmaceutical company focused on the global development and commercialization of biosimilar monoclonal antibodies (mAbs), today announced that Vincent E. Aurentz has joined the Company a

November 10, 2015 EX-24

EPIRUS BIOPHARMACEUTICALS, INC. POWER OF ATTORNEY

Exhibit 24 EPIRUS BIOPHARMACEUTICALS, INC. POWER OF ATTORNEY KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and appoints each of Amit Munshi, Thomas Shea, Robert Ticktin and Marina Breed, with full power of substitution, as the undersigned?s true and lawful attorney-in-fact to: (1) prepare, execute in the undersigned?s name and on the undersigned?s behalf, and submit to the U.

October 7, 2015 8-K

Entry into a Material Definitive Agreement, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 1, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (Co

September 28, 2015 8-K

Entry into a Material Definitive Agreement

8-K 1 a15-1998918k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 24, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Juri

September 9, 2015 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Other Events

8-K 1 a15-1852028k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 9, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Juris

September 9, 2015 EX-2.1

STOCK PURCHASE AGREEMENT REGARDING THE SALE AND TRANSFER OF ALL OUTSTANDING SHARES IN BIOCEROS HOLDING B.V. BY AND AMONG EPIRUS BIOPHARMACEUTICALS, INC., DE BOER BIOTECH CONSULTANCY B.V. UNIVERSITEIT UTRECHT HOLDING B.V. MR. A. BOUT MR. P.J. SIMONS M

Exhibit 2.1 STOCK PURCHASE AGREEMENT REGARDING THE SALE AND TRANSFER OF ALL OUTSTANDING SHARES IN BIOCEROS HOLDING B.V. (?BIOCEROS?) BY AND AMONG EPIRUS BIOPHARMACEUTICALS, INC., (?EPIRUS?) AND DE BOER BIOTECH CONSULTANCY B.V. UNIVERSITEIT UTRECHT HOLDING B.V. MR. A. BOUT MR. P.J. SIMONS MR. L. BOON NODENS B.V. MR. R.M.P. BRANDT MR. M.T. DEN HARTOG MRS. L.M.P. COX MRS. S.Y. MAN MRS. J.A. BIA (?SEL

September 9, 2015 EX-99.1

EPIRUS Biopharmaceuticals Expands Biosimilar Pipeline and Capabilities Through Acquisition of Bioceros

Exhibit 99.1 EPIRUS Biopharmaceuticals Expands Biosimilar Pipeline and Capabilities Through Acquisition of Bioceros ? Combined companies? product pipeline targets reference biologics with sales of $29 billion in 2014 ? Pipeline expanded to include biosimilars to Soliris?, STELARA? and SIMPONI? ? Capabilities enhanced to accelerate product development and optimize quality and yields Boston, MA ? (G

August 12, 2015 EX-10.2

ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE “BUILDING”) SECOND AMENDMENT MAY 29, 2015

Exhibit 10.2 ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE ?BUILDING?) SECOND AMENDMENT MAY 29, 2015 LANDLORD: CPT One Exeter Plaza, LLC, a Delaware limited liability company with a principal place of business c/o AEW Capital Management, L.P., Two Seaport Lane, World Trade Center East, Boston, MA 02210 TENANT: EPIRUS Biopharmaceuticals, Inc., a Delaware corporation EXISTING PREMISES: An area on the

August 12, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

10-Q 1 a15-12149110q.htm 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2015. Or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Comm

August 7, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 a15-1715318k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 7, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdic

August 7, 2015 EX-99.1

EPIRUS Biopharmaceuticals Reports Second Quarter 2015 Financial Results

Exhibit 99.1 EPIRUS Biopharmaceuticals Reports Second Quarter 2015 Financial Results BOSTON?(GlobeNewswire)?August 7, 2015?EPIRUS Biopharmaceuticals, Inc. (Nasdaq:EPRS), a Boston-based, pure-play biosimilar company focused on the global development and commercialization of biosimilar monoclonal antibodies, today announced financial results for the second quarter and six months ended June 30, 2015.

July 16, 2015 CORRESP

EPIRUS Biopharmaceuticals ESP

EPIRUS BIOPHARMACEUTICALS, INC. 699 Boylston Street, Eighth Floor Boston, Massachusetts 02116 July 16, 2015 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Jeffrey P. Riedler, Assistant Director RE: EPIRUS Biopharmaceuticals, Inc. Registration Statement on Form S-3 Filed July 1, 2015 File No. 333-205420

July 14, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 13, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (Comm

July 14, 2015 EX-99.1

EPIRUS Biopharmaceuticals and Polpharma Group Enter into a Multi-Product, Multi-Region, Profit-Sharing Collaboration to Advance Biosimilar Portfolio Targeting $6 Billion Addressable Innovator Market · Profit-sharing collaboration focused on the comme

Exhibit 99.1 EPIRUS Biopharmaceuticals and Polpharma Group Enter into a Multi-Product, Multi-Region, Profit-Sharing Collaboration to Advance Biosimilar Portfolio Targeting $6 Billion Addressable Innovator Market ? Profit-sharing collaboration focused on the commercialization of EPIRUS? biosimilars pipeline in EU, Middle East, Turkey, Russia and CIS territories (?Territories?) ? EPIRUS retains comm

July 13, 2015 SC 13D/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / MONTREUX EQUITY PARTNERS IV LP - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D [Rule 13d-101] (Amendment No.

July 1, 2015 EX-99.1

EPIRUS BIOPHARMACEUTICALS, INC. 2015 EQUITY INCENTIVE PLAN

Exhibit 99.1 EPIRUS BIOPHARMACEUTICALS, INC. 2015 EQUITY INCENTIVE PLAN 1. DEFINED TERMS Exhibit A, which is incorporated by reference, defines the terms used in the Plan and sets forth certain operational rules related to those terms. 2. PURPOSE The Plan has been established to advance the interests of the Company by providing for the grant to Participants of Stock-based and other incentive Award

July 1, 2015 EX-99.2

EPIRUS BIOPHARMACEUTICALS, INC. 2015 EMPLOYEE STOCK PURCHASE PLAN ARTICLE 1.

Exhibit 99.2 EPIRUS BIOPHARMACEUTICALS, INC. 2015 EMPLOYEE STOCK PURCHASE PLAN ARTICLE 1. PURPOSE The purposes of this EPIRUS Biopharmaceuticals, Inc. 2015 Employee Stock Purchase Plan (as it may be amended or restated from time to time, the ?Plan?) are to assist Eligible Employees of EPIRUS Biopharmaceuticals, Inc. (the ?Company?), and its Designated Subsidiaries in acquiring a stock ownership in

July 1, 2015 S-3

As filed with the Securities and Exchange Commission on July 1, 2015

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents As filed with the Securities and Exchange Commission on July 1, 2015 Registration Statement No.

July 1, 2015 EX-4.11

EPIRUS BIOPHARMACEUTICALS, INC. Dated as of , 20 Subordinated Debt Securities

EX-4.11 3 a2225170zex-411.htm EX-4.11 Exhibit 4.11 EPIRUS BIOPHARMACEUTICALS, INC. TO Trustee Indenture Dated as of , 20 Subordinated Debt Securities TABLE OF CONTENTS Page ARTICLE ONE — DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 1 SECTION 101. Definitions 1 SECTION 102. Compliance Certificates and Opinions 8 SECTION 103. Form of Documents Delivered to Trustee 9 SECTION 104. Acts of H

July 1, 2015 EX-4.9

EPIRUS BIOPHARMACEUTICALS, INC. Dated as of , 20 Senior Debt Securities

EX-4.9 2 a2225170zex-49.htm EX-4.9 Exhibit 4.9 EPIRUS BIOPHARMACEUTICALS, INC. TO Trustee Indenture Dated as of , 20 Senior Debt Securities TABLE OF CONTENTS Page ARTICLE ONE — DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 1 SECTION 101. Definitions 1 SECTION 102. Compliance Certificates and Opinions 7 SECTION 103. Form of Documents Delivered to Trustee 8 SECTION 104. Acts of Holders 8 S

July 1, 2015 S-8

EPIRUS Biopharmaceuticals S-8

S-8 1 a15-143913s8.htm S-8 As filed with the Securities and Exchange Commission on July 1, 2015 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 04-3514457 (State or Other Jurisdiction of Incorp

June 9, 2015 EX-3.1

CERTIFICATE OF AMENDMENT SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION EPIRUS BIOPHARMACEUTICALS, INC.

EX-3.1 2 a15-136601ex3d1.htm EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF EPIRUS BIOPHARMACEUTICALS, INC. EPIRUS Biopharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify: 1. The name of the Corporation i

June 9, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

8-K 1 a15-1366018k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 4, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdicti

May 13, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

10-Q 1 a15-7956110q.htm 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2015. Or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Comm

May 13, 2015 EX-10.2

SETTLEMENT AGREEMENT RLS — Epirus BOW015 Manufacturing and Supply Agreement

Exhibit 10.2 SETTLEMENT AGREEMENT Under RLS ? Epirus BOW015 Manufacturing and Supply Agreement This Settlement Agreement, dated as of 22 April, 2015 (the ?Settlement Effective Date?), is by and between Epirus Switzerland GmbH, a Swiss corporation having its principal place of business at General-Guisan-Strasse 6, 6303 Zug, Switzerland (?Epirus?), and Reliance Life Sciences Pvt. Ltd. having its reg

May 12, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 a15-1113618k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 12, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdicti

May 12, 2015 EX-99.1

EPIRUS Biopharmaceuticals Reports First Quarter 2015 Financial Results

Exhibit 99.1 EPIRUS Biopharmaceuticals Reports First Quarter 2015 Financial Results BOSTON?(GlobeNewswire)?May 12, 2015?EPIRUS Biopharmaceuticals, Inc. (Nasdaq: EPRS), a Boston-based biopharmaceutical company focused on the global development and commercialization of biosimilar monoclonal antibodies, today announced financial results for the first quarter ended March 31, 2015. ?We started the year

April 24, 2015 DEFA14A

EPIRUS Biopharmaceuticals DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Defin

April 24, 2015 8-K

EPIRUS Biopharmaceuticals 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 22, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (Com

April 24, 2015 DEF 14A

EPIRUS Biopharmaceuticals DEF 14A

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 14, 2015 PRE 14A

EPIRUS Biopharmaceuticals PRE 14A

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 31, 2015 EX-4.5

Schedule of Warrants

Exhibit 4.5 Schedule of Warrants Date Issued Name of Warrant Holder Number of Shares* Type of Shares Exercise Price* Expiration Date 6/27/2011 Oxford Finance LLC 1,079 Common Stock $ 83.40 12/22/2017 6/27/2011 Oxford Finance LLC 999 Common Stock $ 135.00 12/22/2017 6/27/2011 Oxford Finance LLC 888 Common Stock $ 135.00 12/22/2017 12/16/2011 Oxford Finance LLC 660 Common Stock $ 68.40 12/22/2017 12

March 31, 2015 EX-21.1

Subsidiaries of EPIRUS Biopharmaceuticals, Inc.

EX-21.1 7 a2223738zex-211.htm EX-21.1 Exhibit 21.1 Subsidiaries of EPIRUS Biopharmaceuticals, Inc. Name of Wholly-Owned Subsidiary Jurisdiction of Organization EB Sub, Inc. Delaware Epirus Biopharmaceuticals Ltd. United Kingdom Epirus Switzerland GmbH Switzerland Epirus Brasil Tecnologia Ltda Brazil Zalicus Pharmaceuticals Ltd. Canada

March 31, 2015 EX-10.5

Vest Type

EX-10.5 5 a2223738zex-105.htm EX-10.5 Exhibit 10.5 EPIRUS BIOPHARMACEUTICALS, INC ID: 04-3514457 699 Boylston St 8th Floor Boston, MA 02116 Notice of Grant of Stock Options and Option Agreement <> Option Number: <> < > Plan: 2004 Effective <>, you have been granted a(n) Non-Qualified Stock Option to buy <> shares of EPIRUS BIOPHARMACEUTICALS, INC (the Company) stock at $<> per share. The total opt

March 31, 2015 EX-10.6

<<Name>> Award Number: <<Number>> <<Address>> Plan: 2004

Exhibit 10.6 EPIRUS BIOPHARMACEUTICALS, INC ID: 04-3514457 699 Boylston St 8th Floor Boston, MA 02116 Notice of Grant of Award and Award Agreement <> Award Number: <> < > Plan: 2004 Effective <>, you have been granted an award of <> restricted stock units. These units are restricted until the vest date(s) shown below, at which time you will receive shares of EPIRUS BIOPHARMACEUTICALS, INC (the Com

March 31, 2015 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

Use these links to rapidly review the document TABLE OF CONTENTS EPIRUS Biopharmaceuticals, Inc.

March 31, 2015 EX-4.4

WARRANT TO PURCHASE STOCK (Subdivided Warrant: of )

Exhibit 4.4 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAW OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISF

March 31, 2015 EX-10.4

Vest Type

Exhibit 10.4 EPIRUS BIOPHARMACEUTICALS, INC ID: 04-3514457 699 Boylston St 8th Floor Boston, MA 02116 Notice of Grant of Stock Options and Option Agreement <> Option Number: <> < > Plan: 2004 Effective <>, you have been granted a(n) Incentive Stock Option to buy <> shares of EPIRUS BIOPHARMACEUTICALS, INC (the Company) stock at $<> per share. The total option price of the shares granted is $<>. Sh

March 23, 2015 EX-99.1

EPIRUS Reports Fourth Quarter and Fiscal Year 2014 Financial Results

Exhibit 99.1 EPIRUS Reports Fourth Quarter and Fiscal Year 2014 Financial Results BOSTON?(GlobeNewswire)?March 23, 2015?EPIRUS Biopharmaceuticals, Inc. (Nasdaq: EPRS), a Boston-based biopharmaceutical company focused on the global development of biosimilar monoclonal antibodies, today announced financial results for the fourth quarter and fiscal year ended December 31, 2014. ?In 2014, we became a

March 23, 2015 8-K

EPIRUS Biopharmaceuticals 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 23, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (Com

March 13, 2015 8-K

EPIRUS Biopharmaceuticals 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 13, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (Com

March 13, 2015 EX-99.1

Notice of Dismissal Without Prejudice of Zalicus, Inc. Stockholder Litigation and Agreement Upon Attorneys’ Fees

Exhibit 99.1 Notice of Dismissal Without Prejudice of Zalicus, Inc. Stockholder Litigation and Agreement Upon Attorneys? Fees NEW YORK, March 13, 2015 ? Notice is hereby provided to all persons who held shares of Zalicus, Inc. (?Zalicus?) at any time during the period from and including April 16, 2014 through July 15, 2014. The purpose of this notice is to inform you about developments with respec

February 10, 2015 SC 13D/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / 5AM VENTURES III, L.P. - SCHEDULE 13D/A Activist Investment

SC 13D/A 1 v400959sc13d-a.htm SCHEDULE 13D/A CUSIP NO. 29428P107 13D Page 1 of 13 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 1)* EPIRUS Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per s

February 10, 2015 SC 13G

EPRS / EPIRUS Biopharmaceuticals, Inc. / PRUDENTIAL FINANCIAL INC Passive Investment

13G HTML File DOCUMENT TYPE SC 13G TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 9, 2015 SC 13G

EPRS / EPIRUS Biopharmaceuticals, Inc. / Camber Capital Management LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 EPIRUS Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 29428P107 (CUSIP Number) January 30, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 9, 2015 SC 13D/A

EPRS / EPIRUS Biopharmaceuticals, Inc. / MONTREUX EQUITY PARTNERS IV LP - SC 13D/A Activist Investment

SC 13D/A 1 a15-40231sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D [Rule 13d-101] (Amendment No. 1)* INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 240.13d-2(a) EPIRUS Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 29428P10

February 9, 2015 EX-1

JOINT FILING AGREEMENT

EX-1 2 camberepirus13gexh1.htm JOINT FILING AGREEMENT EXHIBIT 1 JOINT FILING AGREEMENT This Joint Filing Agreement dated February 9, 2015 is by and between Camber Capital Management LLC, a Massachusetts limited liability company, and Stephen DuBois, an individual (the foregoing are collectively referred to herein as the "Filers"). Each of the Filers may be required to file with the United States S

February 6, 2015 SC 13G

EPRS / EPIRUS Biopharmaceuticals, Inc. / Broadfin Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

January 30, 2015 EX-99.1

EPIRUS Announces Proposed Public Offering of Common Stock

Exhibit 99.1 EPIRUS Announces Proposed Public Offering of Common Stock BOSTON—(BUSINESS WIRE)—January 26, 2015—EPIRUS Biopharmaceuticals, Inc. (NASDAQ: EPRS), a Boston-based biopharmaceutical company focused on the global development of biosimilar monoclonal antibodies, announced today that it has commenced an underwritten public offering of shares of its common stock. EPIRUS intends to grant the

January 30, 2015 EX-99.2

EPIRUS Prices $48 Million Public Offering of Common Stock

Exhibit 99.2 EPIRUS Prices $48 Million Public Offering of Common Stock BOSTON—(BUSINESS WIRE)—January 30, 2015—EPIRUS Biopharmaceuticals, Inc. (NASDAQ: EPRS), a Boston-based biopharmaceutical company focused on the global development of biosimilar monoclonal antibodies, announced today the pricing of an underwritten public offering of 9.6 million shares of its common stock, offered at a price to t

January 30, 2015 424B5

9,600,000 Shares Common Stock

424B5 1 a2222902z424b5.htm 424B5 Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-183538 Registration No. 333-201760 PROSPECTUS SUPPLEMENT (To prospectus dated September 17, 2012) 9,600,000 Shares Common Stock We are offering 9,600,000 shares of our common stock. Our common stock is listed on

January 30, 2015 EX-1.1

9,600,000 Shares EPIRUS BIOPHARMACEUTICALS, INC. Common Stock, Par Value $0.001 Per Share UNDERWRITING AGREEMENT

Exhibit 1.1 9,600,000 Shares EPIRUS BIOPHARMACEUTICALS, INC. Common Stock, Par Value $0.001 Per Share UNDERWRITING AGREEMENT January 29, 2015 Leerink Partners LLC 299 Park Avenue, 21st Floor New York, NY 10171 Ladies and Gentlemen: EPIRUS Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several Underwriters named in Schedule I hereto (the “Underwr

January 30, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 29, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (C

January 29, 2015 S-3MEF

EPRS / EPIRUS Biopharmaceuticals, Inc. S-3MEF - - S-3MEF

As filed with the Securities and Exchange Commission on January 29, 2015 Registration No.

January 26, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Termination of a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

8-K 1 a15-305138k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 21, 2015 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdi

January 26, 2015 EX-99.2

RISK FACTORS

Exhibit 99.2 RISK FACTORS Our business faces significant risks and uncertainties. Certain important factors may have a material adverse effect on our business prospects, financial condition and results of operations, and you should carefully consider them. Accordingly, in evaluating our business, we encourage you to consider the following discussion of risk factors, in its entirety, in addition to

January 26, 2015 424B5

SUBJECT TO COMPLETION, DATED JANUARY 26, 2015

Use these links to rapidly review the document Table of Contents TABLE OF CONTENTS Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No.

January 26, 2015 EX-99.1

BUSINESS

Exhibit 99.1 BUSINESS Overview We are a commercial-stage biopharmaceutical company focused on improving patient access to important biopharmaceuticals by developing, manufacturing, and commercializing biosimilar therapeutics, or biosimilars, in targeted geographies worldwide. We seek to build a sustainable, profitable biosimilar company with a pipeline of operationally synergistic monoclonal antib

January 26, 2015 EX-10.1

EPIRUS BIOPHARMACEUTICALS, INC. SEVERANCE PLAN

Exhibit 10.1 EPIRUS BIOPHARMACEUTICALS, INC. SEVERANCE PLAN SECTION 1. Purpose. The purpose of this Severance Plan (this “Plan”) is to encourage certain management-level employees of EPIRUS Biopharmaceuticals, Inc. (the “Company”) and its subsidiaries to remain in the employ of the Company and its subsidiaries by providing severance protections to such employees in the event their employment is te

December 5, 2014 8-K

Other Events

8-K 1 a14-2570718k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 5, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisd

November 10, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2014. o TRANSITION REPORT PURSUAN

10-Q 1 a14-21803110q.htm 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2014. Or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

November 10, 2014 EX-10.1

AMENDMENT No. 1 to RANBAXY — EPIRUS LICENSE AGREEMENT

EX-10.1 2 a14-218031ex10d1.htm EX-10.1 Exhibit 10.1 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. AMENDMENT No. 1 to RANBAXY — EPIRUS LICENSE AGREEMENT This Amendment No. 1, dated as of 09 September, 2014 (the “Amendment Effective Date”), t

November 10, 2014 EX-99.1

EPIRUS MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

EX-99.1 8 a14-218031ex99d1.htm EX-99.1 Exhibit 99.1 EPIRUS MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS You should read the following discussion of our financial condition and results of operations in conjunction with “Selected historical consolidated financial information” and the financial statements and related notes, all included elsewhere in this joint

November 10, 2014 EX-10.4

EXCLUSIVE LICENSE AND COLLABORATION AGREEMENT BY AND BETWEEN EPIRUS SWITZERLAND GmbH LIVZON MABPHARM INC.

EX-10.4 3 a14-218031ex10d4.htm EX-10.4 Exhibit 10.4 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. EXCLUSIVE LICENSE AND COLLABORATION AGREEMENT BY AND BETWEEN EPIRUS SWITZERLAND GmbH AND LIVZON MABPHARM INC. 1. DEFINITIONS 1 2. LICENSES 7 2

November 10, 2014 EX-99.1

EPIRUS Biopharmaceuticals Reports Third Quarter Results and Provides Corporate Update

Exhibit 99.1 EPIRUS Biopharmaceuticals Reports Third Quarter Results and Provides Corporate Update BOSTON, MA — November 10, 2014 - EPIRUS Biopharmaceuticals, Inc. (EPIRUS, NASDAQ: EPRS), a Boston-based biopharmaceutical company focused on the global development and commercialization of biosimilar monoclonal antibodies, today provided a corporate update and reported financial results for the third

November 10, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 10, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation) (

November 10, 2014 EX-10.6

ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE “BUILDING”) FIRST AMENDMENT MAY 15, 2014

EX-10.6 4 a14-218031ex10d6.htm EX-10.6 Exhibit 10.6 ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE “BUILDING”) FIRST AMENDMENT MAY 15, 2014 LANDLORD: CPT One Exeter Plaza, LLC, a Delaware limited liability company with a principal place of business c/o AEW Capital Management, L.P., Two Seaport Lane, World Trade Center East, Boston, MA 02210 TENANT: EPIRUS Biopharmaceuticals, Inc., a Delaware corporat

October 31, 2014 EX-10.1

SECOND AMENDMENT TO THE REVENUE AND NEGOTIATION RIGHTS AGREEMENT

Exhibit 10.1 EXECUTION DRAFT SECOND AMENDMENT TO THE REVENUE AND NEGOTIATION RIGHTS AGREEMENT By this private instrument, the Parties, EPIRUS SWITZERLAND GMBH, a corporation organized under the laws of Switzerland, with registered office at General-Guisan-Strasse 6, 6303 Zug Switzerland (hereinafter referred to as “EPIRUS”), and as a successor to FOURTEEN22, INC. (“FOURTEEN22”), represented herein

October 31, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 a14-2341018k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 29, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisd

October 3, 2014 EX-4.1

WARRANT AGREEMENT To Purchase Shares of the Common Stock of EPIRUS Biopharmaceuticals, Inc. Dated as of September 30, 2014 (the “Effective Date”)

Exhibit 4.1 THIS WARRANT AND THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR, SUBJECT TO SECTION 11 HEREOF, AN OPINION OF COUNSEL (WHICH MAY BE COMPANY COUNS

October 3, 2014 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

8-K 1 a14-2182718k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 30, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Juri

October 3, 2014 EX-10.1

LOAN AND SECURITY AGREEMENT

Exhibit 10.1 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT is made and dated as of September 30, 2014 and is entered into by and between EPIRUS BIOPHARMACEUTICALS, INC., a Delaware corporation (“Borrower”), the several banks and other financial institutions or entities from time to time parties to this Agreement (collectively, referred to as “Lender”) and HERCULES TECHNOLOGY GROWTH

September 29, 2014 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 a14-2157118k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 24, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Juri

September 29, 2014 EX-99.1

EPIRUS and Livzon Mabpharm, Inc. Enter Collaboration Agreement for China Partners to develop, manufacture and commercialize up to five biosimilars, including EPIRUS’ BOW015, for Asian markets

Exhibit 99.1 EPIRUS and Livzon Mabpharm, Inc. Enter Collaboration Agreement for China Partners to develop, manufacture and commercialize up to five biosimilars, including EPIRUS’ BOW015, for Asian markets BOSTON, September 25, 2014 - EPIRUS Biopharmaceuticals, Inc. (EPIRUS, NASDAQ: EPRS), a Boston-based biopharmaceutical company focused on the global development and commercialization of biosimilar

September 29, 2014 EX-10.1

FIRST AMENDMENT TO THE REVENUE AND NEGOTIATION RIGHTS AGREEMENT

Exhibit 10.1 EXECUTION VERSION FIRST AMENDMENT TO THE REVENUE AND NEGOTIATION RIGHTS AGREEMENT By this private instrument, the Parties, EPIRUS SWITZERLAND GMBH, a corporation organized under the laws of Switzerland, with registered office at General-Guisan-Strasse 6, 6303 Zug Switzerland (hereinafter referred to as “EPIRUS”), and as a successor to FOURTEEN22, INC. (“FOURTEEN22”), represented herei

September 23, 2014 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 23, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 000-51171 04-3514457 (State or Other Jurisdiction of Incorporation)

September 23, 2014 EX-99.1

EPIRUS Announces Positive 58 Week Follow Up Data for BOW015 for treatment of Rheumatoid Arthritis BOW015 demonstrates therapeutic equivalence to Remicade® and confirms the safety of switching from Remicade to BOW015

Exhibit 99.1 EPIRUS Announces Positive 58 Week Follow Up Data for BOW015 for treatment of Rheumatoid Arthritis BOW015 demonstrates therapeutic equivalence to Remicade® and confirms the safety of switching from Remicade to BOW015 BOSTON, September 23, 2014 - EPIRUS Biopharmaceuticals, Inc. (EPIRUS, NASDAQ: EPRS), a Boston-based biopharmaceutical company focused on the global development and commerc

September 15, 2014 8-K

Entry into a Material Definitive Agreement

8-K 1 d788753d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorpo

August 29, 2014 SC 13D

EPRS / EPIRUS Biopharmaceuticals, Inc. / 5AM VENTURES III, L.P. - SCHEDULE 13D Activist Investment

SC 13D 1 v388032sc13d.htm SCHEDULE 13D CUSIP NO. 29428P107 13D Page 1 of 13 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. )* EPIRUS Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (T

August 11, 2014 EX-10.11

June 15th, 2012

EX-10.11 Exhibit 10.11 June 15th, 2012 Michael Wyand Dear Michael: I am pleased to offer you a position with Fourteen22, Inc., a Delaware corporation (the “Company”), as its SVP of Clinical & Regulatory, reporting to the office of the CEO of the Company and shall begin on June 15th, 2012. If you decide to join us, you will receive an annual salary of $280,000, which will be paid in accordance with

August 11, 2014 EX-99.2

AMENDMENT NO. 1 AMENDED AND RESTATED 2004 INCENTIVE PLAN

EX-99.2 5 d761619dex992.htm EX-99.2 Exhibit 99.2 AMENDMENT NO. 1 TO AMENDED AND RESTATED 2004 INCENTIVE PLAN The Amended and Restated 2004 Incentive Plan (the “Plan”) of Zalicus Inc., a Delaware corporation (the “Company”), is hereby amended by the Board of Directors and stockholders of the Company, as follows: 1. The first sentence of Section 4(a) of the Plan is hereby deleted in its entirety and

August 11, 2014 EX-4.3

FOURTEEN22, INC. WARRANT TO PURCHASE PREFERRED STOCK No. PSW-9 April 3, 2012 Void After April 3, 2019

EX-4.3 Exhibit 4.3 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEM

August 11, 2014 EX-4.2

FOURTEEN22, INC. WARRANT TO PURCHASE SERIES A PREFERRED STOCK No. PSW-5 January 25, 2011 Void After January 25, 2018

EX-4.2 Exhibit 4.2 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEM

August 11, 2014 EX-4.1

ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK PAR VALUE $0.01 EPIRUS BIOPHARMACEUTIOALSTM COMMON STOCK THIS CERTIFICATE IS TRANSFERABLE IN CANTON, MA, JERSEY CITY, NJ AND COLLEGE STATION, TX EPIRUS BIOPHARMACEUTICALS, INC. INCORPOR

EX-4.1 Exhibit 4.1 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK PAR VALUE $0.01 EPIRUS BIOPHARMACEUTIOALSTM COMMON STOCK THIS CERTIFICATE IS TRANSFERABLE IN CANTON, MA, JERSEY CITY, NJ AND COLLEGE STATION, TX EPIRUS BIOPHARMACEUTICALS, INC. INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE THIS CERTIFIES THAT ** Mr. Alexander David Sample **** Mr. Alexander David Sample ****

August 11, 2014 EX-10.10

April 23, 2014

EX-10.10 Exhibit 10.10 April 23, 2014 Robert Ticktin Dear Robert: I am pleased to offer you a position with Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), as General Counsel. Your employment shall begin on April 28, 2014. If you decide to join us, you will receive an annual salary of $275,000, which will be paid in accordance with the Company’s normal payroll procedures a

August 11, 2014 EX-10.12

Amit Munshi

EX-10.12 Exhibit 10.12 Amit Munshi Dear Amit; Thank you for your very important contributions to EPIRUS in 2013. Your new salary for 2014 is $450,000 effective as of April 16, 2014. Your new 2014 bonus eligibility is 50%. We look forward to your contributions in 2014 and value you as a member of the EPIRUS team. Sincerely, /s/ Thomas Shea Thomas Shea Chief Financial Officer

August 11, 2014 EX-10.9

April 29, 2013

EX-10.9 Exhibit 10.9 April 29, 2013 Thomas Shea Dear Thomas: I am pleased to offer you a position with EPIRUS Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), as the Chief Financial Officer (CFO), reporting to Amit Munshi; President & CEO. Your employment shall begin on May 20th, 2013. If you decide to join us, you will receive an annual salary of $275,000, which will be paid in a

August 11, 2014 EX-10.7

May 17, 2012

EX-10.7 Exhibit 10.7 May 17, 2012 Amit Munshi Dear Amit: I am pleased to offer you a position with Fourteen22, Inc., a Delaware corporation (the “Company”), as its Chief Executive Officer, reporting to the Board of Directors of the Company. If you accept this offer, the Board of Directors will also appoint you as a Director of the Company and its President to serve during the period that you are t

August 11, 2014 EX-10.5

SECOND DEFENITIVE LICENSE AGREEMENT

EX-10.5 Exhibit 10.5 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. SECOND DEFENITIVE LICENSE AGREEMENT This SECOND DEFENITIVE LICENSE AGREEMENT (the “Agreement”) is made as of October 1st, 2013 (the “Effective Date”) by and between Epirus B

August 11, 2014 EX-10.4

LICENSE AGREEMENT

EX-10.4 Exhibit 10.4 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. EXECUTION VERSION 10/04/13 LICENSE AGREEMENT This LICENSE AGREEMENT (the “Agreement”) is made as of 10th of April (the “Effective Date”) by and between Epirus Biopharmaceuti

August 11, 2014 EX-10.3

REVENUE AND NEGOTIATION RIGHTS AGREEMENT

EX-10.3 Exhibit 10.3 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. REVENUE AND NEGOTIATION RIGHTS AGREEMENT This Revenue and Negotiation Rights Agreement (the “Agreement”), dated as of December 31, 2010 (the “Effective Date”), is entered in

August 11, 2014 EX-4.5

FOURTEEN22, INC. WARRANT TO PURCHASE PREFERRED STOCK No. PSW-16 April 3, 2012 Void After April 3, 2019

EX-4.5 Exhibit 4.5 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEM

August 11, 2014 EX-10.16

LEASE AGREEMENT ONE EXETER PLAZA 699 BOYLSTON ST., BOSTON, MASSACHUSETTS L E A S E CPT ONE EXETER PLAZA, LLC, A DELAWARE LIMITED LIABILITY COMPANY EPIRUS BIOPHARMACEUTICALS, INC. DATE: MARCH 8, 2013 TABLE OF CONTENTS ARTICLE 1 BASIC LEASE PROVISIONS

EX-10.16 Exhibit 10.16 LEASE AGREEMENT ONE EXETER PLAZA 699 BOYLSTON ST., BOSTON, MASSACHUSETTS L E A S E FROM CPT ONE EXETER PLAZA, LLC, A DELAWARE LIMITED LIABILITY COMPANY TO EPIRUS BIOPHARMACEUTICALS, INC. DATE: MARCH 8, 2013 TABLE OF CONTENTS ARTICLE 1 BASIC LEASE PROVISIONS 1 ARTICLE 2 PREMISES 4 ARTICLE 3 LEASE TERM AND EXTENSION OPTIONS 5 ARTICLE 4 LANDLORD’S WORK 6 ARTICLE 5 USE OF PREMIS

August 11, 2014 EX-10.2

GPEx® CELL LINE SALE AGREEMENT

EX-10.2 Exhibit 10.2 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. GPEx® CELL LINE SALE AGREEMENT This GPEx® Cell Line Sale Agreement (“Agreement”) is made and is effective as of this 1st day of January, 2009 (the “Effective Date”), by and

August 11, 2014 EX-10.8

February 4, 2014

EX-10.8 Exhibit 10.8 February 4, 2014 Mr. Kim A. Seth By: Email Dear Kim I am pleased to offer you a position with Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), as the Senior Vice President & Chief Business Officer. Your employment shall begin on February 10, 2014 If you decide to join us, you will receive an annual salary of $280,000, which will be paid in accordance wi

August 11, 2014 EX-4.4

FOURTEEN22, INC. WARRANT TO PURCHASE PREFERRED STOCK No. PSW-11 April 3, 2012 Void After April 3, 2019

EX-4.4 Exhibit 4.4 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEM

August 11, 2014 EX-4.6

FOURTEEN22, INC. WARRANT TO PURCHASE PREFERRED STOCK No. PSW-17 April 3, 2012 Void After April 3, 2019

EX-4.6 Exhibit 4.6 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEM

August 11, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Form 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 11, 2014 EX-10.13

Kim Seth

EX-10.13 Exhibit 10.13 Kim Seth Dear Kim; Your new salary for 2014 is $300,000 effective as of April 16, 2014. Your new 2014 bonus eligibility is 35%. We look forward to your contributions in 2014 and value you as a member of the EPIRUS team. Sincerely, /s/ Amit Munshi Amit Munshi Chief Executive Officer

August 11, 2014 EX-4.7

FOURTEEN22, INC. WARRANT TO PURCHASE PREFERRED STOCK No. PSW-22 August 21, 2012 Void After August 21, 2019

EX-4.7 Exhibit 4.7 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEM

August 11, 2014 EX-10.14

Tom Shea

EX-10.14 Exhibit 10.14 Tom Shea Dear Tom; Thank you for your very important contributions to EPIRUS in 2013. Your new salary for 2014 is $300,000 effective as of April 16, 2014. Your new 2014 bonus eligibility is 35%. We look forward to your contributions in 2014 and value you as a member of the EPIRUS team. Sincerely, /s/ Amit Munshi Amit Munshi Chief Executive Officer

August 11, 2014 EX-10.15

Michael Wyand

EX-10.15 Exhibit 10.15 Michael Wyand Dear Michael; Thank you for your very important contributions to EPIRUS in 2013. Your new salary for 2014 is $300,000 effective as of April 16, 2014. Your new 2014 bonus eligibility is 35%. We look forward to your contributions in 2014 and value you as a member of the EPIRUS team. Sincerely, /s/ Amit Munshi Amit Munshi Chief Executive Officer

August 11, 2014 EX-10.6

LICENSE AGREEMENT

EX-10.6 Exhibit 10.6 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. LICENSE AGREEMENT THIS LICENSE AGREEMENT (the “Agreement”) is made and entered into as of 3rd January 2014 (the “Effective Date”) between Epirus Switzerland GmbH, a Swiss co

August 11, 2014 S-8

EPRS / EPIRUS Biopharmaceuticals, Inc. S-8 - - S-8

S-8 1 d761619ds8.htm S-8 Registration No. 333- As filed with the Securities and Exchange Commission on August 11, 2014 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EPIRUS BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 04-3514457 (State or Other Jurisdiction of Incor

August 5, 2014 SC 13G

EPRS / EPIRUS Biopharmaceuticals, Inc. / Livzon MABPharm Inc. - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Amendment No. ) Under the Securities Exchange Act of 1934 Epirus Biopharmaceuticals, Inc. (Name of Issuer) COMMON STOCK, $0.001 PER SHARE PAR VALUE (Title of Class of Securities) 29428P 107 (CUSIP Number) July 15, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to des

July 25, 2014 SC 13D

EPRS / EPIRUS Biopharmaceuticals, Inc. / TPG Group Holdings (SBS) Advisors, Inc. Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D [Rule 13d-101] INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.

July 25, 2014 EX-99.I

AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13D

Exhibit I AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13D The undersigned hereby agree as follows: (i) Each of them is individually eligible to use the Schedule 13D to which this Exhibit is attached, and such Schedule 13D is filed on behalf of each of them; and (ii) Each of them is responsible for the timely filing of such Schedule 13D and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate.

July 25, 2014 SC 13D

EPRS / EPIRUS Biopharmaceuticals, Inc. / MONTREUX EQUITY PARTNERS IV LP - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* EPIRUS Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 29428P107 (CUSIP Number) Daniel K. Turner, III One Ferry Building, Suite 255, San Francisco, CA 94111. (650) 234-1200 (Name, Address a

July 18, 2014 EX-10.2

May 27, 2014

EX-10.2 Exhibit 10.2 May 27, 2014 Mark Corrigan Dear Mark, We are very pleased, in connection with the merger between Epirus and Zalicus Inc. (to be renamed EPIRUS Biopharmaceuticals, Inc., for purposes herein, the “Company”) to offer you the position as Chairman of the Company’s Board of Directors (the “Board”). Your appointment is based on the following terms and conditions: Effective Date: Your

July 18, 2014 EX-3.01

AMENDED AND RESTATED BY-LAWS OF EPIRUS BIOPHARMACEUTICALS, INC. ARTICLE 1 - OFFICES 1 1.1 REGISTERED OFFICES 1 1.2 OTHER OFFICES 1 1.3 BOOKS 1 ARTICLE 2 - STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 NOTICE OF

EX-3.01 Exhibit 3.01 AMENDED AND RESTATED BY-LAWS OF EPIRUS BIOPHARMACEUTICALS, INC. ARTICLE 1 - OFFICES 1 1.1 REGISTERED OFFICES 1 1.2 OTHER OFFICES 1 1.3 BOOKS 1 ARTICLE 2 - STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 NOTICE OF MEETINGS 1 2.5 VOTING LIST 2 2.6 QUORUM 2 2.7 ADJOURNMENTS 2 2.8 VOTING AND PROXIES 2 2.9 PROXY REPRESENTATION 2 2.10 ACTION AT

July 18, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2014 EPIRUS BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514

July 18, 2014 EX-10.4

July 1, 2014

EX-10.4 5 d757967dex104.htm EX-10.4 Exhibit 10.4 July 1, 2014 Julie McHugh Dear Julie, We are very pleased to name you as one of our director designees in connection with the merger between Epirus and Zalicus Inc. (to be renamed EPIRUS Biopharmaceuticals, Inc., for purposes herein, the “Company”). Your appointment to become a member of the Company’s Board of Directors (the “Board”) is based on the

July 18, 2014 EX-10.5

EPIRUS Biopharmaceuticals, Inc. Non-Employee Director Compensation Policy

EX-10.5 Exhibit 10.5 EPIRUS Biopharmaceuticals, Inc. Non-Employee Director Compensation Policy Effective as of July 15, 2014 (the “Effective Date”), each member of the Board of Directors (the “Board”) who is not also serving as an employee of EPIRUS Biopharmaceuticals (the “Company”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in th

July 18, 2014 EX-10.3

May 22, 2014

EX-10.3 Exhibit 10.3 May 22, 2014 Bill Hunter Dear Bill, We are very pleased to name you as one of our director designees in connection with the merger between Epirus and Zalicus Inc. (to be renamed EPIRUS Biopharmaceuticals, Inc., for purposes herein, the “Company”). Your appointment to become a member of the Company’s Board of Directors of the (the “Board”) is based on the following terms and co

July 15, 2014 8-K

Regulation FD Disclosure, Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Submission of Matters to a Vote of Security Holders

8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

July 15, 2014 EX-99.1

EPIRUS and Zalicus Complete Merger - Combined Company Will Trade as EPIRUS Biopharmaceuticals, Inc. (NASDAQ: EPRS)

EX-99.1 EXHIBIT 99.1 EPIRUS and Zalicus Complete Merger - Combined Company Will Trade as EPIRUS Biopharmaceuticals, Inc. (NASDAQ: EPRS) • 1:10 Reverse Stock Split will be effective before trading opens on July 16 • EPIRUS reconstitutes Board of Directors to include Mark H.N. Corrigan, M.D., Julie H. McHugh, William Hunter, M.D., Amit Munshi, Geoffrey Duyk, Scott Rocklage, J. Kevin Buchi and Daotia

July 15, 2014 EX-3.1

CERTIFICATE OF AMENDMENT SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION ZALICUS INC.

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ZALICUS INC. Zalicus Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify: 1. The name of the Corporation is Zalicus Inc. The date of the filing of the Corporation’s original

July 15, 2014 EX-3.2

CERTIFICATE OF AMENDMENT SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION EPIRUS BIOPHARMACEUTICALS, INC.

EX-3.2 Exhibit 3.2 CERTIFICATE OF AMENDMENT OF SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF EPIRUS BIOPHARMACEUTICALS, INC. EPIRUS Biopharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify: 1. The name of the Corporation is EPIRUS Biopharmaceuticals,

July 15, 2014 EX-99.2

Mark H.N. Corrigan, M.D., Julie H. McHugh, and William Hunter, M.D. to Serve on EPIRUS Board of

EX-99.2 EXHIBIT 99.2 Mark H.N. Corrigan, M.D., Julie H. McHugh, and William Hunter, M.D. to Serve on EPIRUS Board of Directors BOSTON, July 15, 2014 - EPIRUS Biopharmaceuticals, Inc. (EPIRUS, NASDAQ: EPRS), a Boston-based biopharmaceutical company focused on the global development and commercialization of biosimilar monoclonal antibodies, announced that Mark H.N. Corrigan, M.D., Julie H. McHugh, a

July 2, 2014 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2014 ZALICUS INC. (Exact

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission Fil

July 2, 2014 8-K

Termination of a Material Definitive Agreement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission Fil

June 27, 2014 SC 14F1

- SC 14F1

SC 14F1 1 d750806dsc14f1.htm SC 14F1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14f-1 INFORMATION STATEMENT PURSUANT TO SECTION 14f OF THE SECURITIES EXCHANGE ACT OF 1934 AND RULE 14f-1 THEREUNDER ZALICUS INC. (Exact name of registrant as specified in its charter) Delaware 000-51171 04-3514457 (State or other jurisdiction of incorporation) (Commission File Num

June 25, 2014 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission Fil

June 25, 2014 EX-99.1

ZALICUS AND EPIRUS AGREE ZALICUS STOCKHOLDERS TO OWN 19% OF COMBINED COMPANY POST-MERGER

EX-99.1 Exhibit 99.1 ZALICUS AND EPIRUS AGREE ZALICUS STOCKHOLDERS TO OWN 19% OF COMBINED COMPANY POST-MERGER BOSTON, June 25, 2014 - Zalicus Inc. (Nasdaq Capital Market: ZLCS) (“Zalicus”), and Epirus Biopharmaceuticals, Inc. (“Epirus”) agreed today that Zalicus stockholders will own 19% of the combined company post-merger. Pursuant to its merger agreement with Epirus Biopharmaceuticals, Inc., the

June 25, 2014 EX-99.1

ZALICUS AND EPIRUS AGREE ZALICUS STOCKHOLDERS TO OWN 19% OF COMBINED COMPANY POST-MERGER

EX-99.1 Exhibit 99.1 ZALICUS AND EPIRUS AGREE ZALICUS STOCKHOLDERS TO OWN 19% OF COMBINED COMPANY POST-MERGER BOSTON, June 25, 2014 - Zalicus Inc. (Nasdaq Capital Market: ZLCS) (“Zalicus”), and Epirus Biopharmaceuticals, Inc. (“Epirus”) agreed today that Zalicus stockholders will own 19% of the combined company post-merger. Pursuant to its merger agreement with Epirus Biopharmaceuticals, Inc., the

June 25, 2014 425

Merger Prospectus - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission Fil

June 18, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission Fil

June 18, 2014 EX-10.1

EXCLUSIVE LICENSE AGREEMENT

EX-10.1 Exhibit 10.1 EXCLUSIVE LICENSE AGREEMENT THIS LICENSE AGREEMENT hereinafter (“AGREEMENT”) is made and entered into as of June 17, 2014 (hereinafter the “EFFECTIVE DATE”) by and between Zalicus Pharmaceuticals Ltd., c/o Zalicus Inc., with its principal place of business located at 245 First St. Third Floor, Cambridge, MA 02142 (hereinafter referred to as “ZALICUS” or “LICENSOR”), and AnaBio

June 18, 2014 425

Merger Prospectus - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No.) (I

June 18, 2014 EX-99.1

ZALICUS LICENSES SODIUM CHANNEL PAIN MODULATION PROGRAM Exclusive Rights Licensed to AnaBios Corporation in Exchange for more than $17 Million in Potential Milestone Payments and Up to 12% in Potential Sales Royalties

EX-99.1 Exhibit 99.1 Filed by Zalicus Inc. Pursuant to Rule 425 under Securities Act of 1933, as amended and deemed filed pursuant to Rule 14a-12 of the Securities Exchange Act of 1934 Subject Company: Zalicus Inc. Registration Statement File No.: 333-195818 ZALICUS LICENSES SODIUM CHANNEL PAIN MODULATION PROGRAM Exclusive Rights Licensed to AnaBios Corporation in Exchange for more than $17 Millio

June 18, 2014 EX-10.1

EXCLUSIVE LICENSE AGREEMENT

EX-10.1 2 d745020dex101.htm EX-10.1 Exhibit 10.1 EXCLUSIVE LICENSE AGREEMENT THIS LICENSE AGREEMENT hereinafter (“AGREEMENT”) is made and entered into as of June 17, 2014 (hereinafter the “EFFECTIVE DATE”) by and between Zalicus Pharmaceuticals Ltd., c/o Zalicus Inc., with its principal place of business located at 245 First St. Third Floor, Cambridge, MA 02142 (hereinafter referred to as “ZALICUS

June 18, 2014 EX-99.1

ZALICUS LICENSES SODIUM CHANNEL PAIN MODULATION PROGRAM Exclusive Rights Licensed to AnaBios Corporation in Exchange for more than $17 Million in Potential Milestone Payments and Up to 12% in Potential Sales Royalties

EX-99.1 Exhibit 99.1 Filed by Zalicus Inc. Pursuant to Rule 425 under Securities Act of 1933, as amended and deemed filed pursuant to Rule 14a-12 of the Securities Exchange Act of 1934 Subject Company: Zalicus Inc. Registration Statement File No.: 333-195818 ZALICUS LICENSES SODIUM CHANNEL PAIN MODULATION PROGRAM Exclusive Rights Licensed to AnaBios Corporation in Exchange for more than $17 Millio

June 6, 2014 EX-99.1

UNAUDITED PRO FORMA CONDENSED FINANCIAL STATEMENTS

EX-99.1 Exhibit 99.1 UNAUDITED PRO FORMA CONDENSED FINANCIAL STATEMENTS On June 2, 2014, Zalicus Inc. (“Zalicus” or the “Company”) completed the sale of its combination High Throughput Screening platform (the “cHTS Business”) and certain assets and liabilities related to the cHTS Business to Horizon Discovery Limited, an English private limited company, and Horizon Discovery Inc., a privately held

June 6, 2014 425

Merger Prospectus - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File

June 6, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Completion of Acquisition or Disposition of Assets - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File

June 6, 2014 424B3

245 First Street, Third Floor Cambridge, Massachusetts 02142

424B3 1 d712283d424b3.htm 424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-195818 245 First Street, Third Floor Cambridge, Massachusetts 02142 June 6, 2014 Dear Stockholder: You are cordially invited to attend the 2014 Annual Meeting of Stockholders (the “Annual Meeting”) of Zalicus Inc. (“Zalicus” or the “Company”) to be held on July 15, 2014, at 9:00 a.m. local time,

June 6, 2014 EX-99.1

UNAUDITED PRO FORMA CONDENSED FINANCIAL STATEMENTS

EX-99.1 Exhibit 99.1 UNAUDITED PRO FORMA CONDENSED FINANCIAL STATEMENTS On June 2, 2014, Zalicus Inc. (“Zalicus” or the “Company”) completed the sale of its combination High Throughput Screening platform (the “cHTS Business”) and certain assets and liabilities related to the cHTS Business to Horizon Discovery Limited, an English private limited company, and Horizon Discovery Inc., a privately held

June 5, 2014 CORRESP

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CORRESP 1 filename1.htm June 5, 2014 VIA EDGAR TRANSMISSION AND FACSIMILE United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-3628 Attn: Jeffrey P. Riedler, Assistant Director Re: Zalicus Inc. Registration Statement on Form S-4 Filed May 8, 2014 File No. 333-195818 Dear Mr. Riedler: Pursuant to Rule 461 of the Securities Act of

June 4, 2014 EX-99.3

THIS SPECIAL MEETING PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED.

EX-99.3 7 d712283dex993.htm EX-99.3 EXHIBIT 99.3 EPIRUS BIOPHARMACEUTICALS, INC. ATTN: EDWARD SCOTT 699 BOYLSTON ST. 11th FLOOR BOSTON, MA 02116 VOTE BY MAIL Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to EPIRUS Biopharmaceuticals, Inc., Attn: Edward Scott, 699 Boylston St. 11th Floor, Boston, MA 02116. TO VOTE, MARK BLOCKS BELOW IN

June 4, 2014 EX-99.2

FORM OF PROXY ZALICUS INC. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS 2014 Annual Meeting of Stockholders To Be Held On July 15, 2014 at 9:00 a.m., local time

EX-99.2 6 d712283dex992.htm EX-99.2 EXHIBIT 99.2 FORM OF PROXY ZALICUS INC. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS 2014 Annual Meeting of Stockholders To Be Held On July 15, 2014 at 9:00 a.m., local time The undersigned stockholder of Zalicus Inc. (the “Company”) hereby acknowledges receipt of the Notice of 2014 Annual Meeting of Stockholders and the Joint Proxy Statement/Pros

June 4, 2014 S-4/A

- AMENDMENT NO. 1 TO FORM S-4

S-4/A 1 d712283ds4a.htm AMENDMENT NO. 1 TO FORM S-4 Table of Contents As filed with the Securities and Exchange Commission on June 4, 2014 Registration No. 333-195818 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO.1 TO FORM S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ZALICUS INC. (Exact name of registrant as specified in its charter) Delaware 2

June 4, 2014 CORRESP

-

CORRESP June 4, 2014 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

June 2, 2014 425

Merger Prospectus - 425

425 Filed by Zalicus Inc. Pursuant to Rule 425 under Securities Act of 1933, as amended and deemed filed pursuant to Rule 14a-12 of the Securities Exchange Act of 1934 Subject Company: Zalicus Inc. Registration Statement File No.: 333-195818 ZALICUS ANNOUNCES CLOSING OF cHTS SERVICE BUSINESS SALE TO HORIZON DISCOVERY GROUP Combination High Throughput Screening Platform and Related Assets Sold for

May 22, 2014 425

Merger Prospectus - 425

425 1 d732432d425.htm 425 Filed by Zalicus Inc. Pursuant to Rule 425 under Securities Act of 1933, as amended and deemed filed pursuant to Rule 14a-6 of the Securities Exchange Act of 1934 Subject Company: Zalicus Inc. Registration Statement File No.: 333-195818 ZALICUS UPDATES PROGRESS ON Z944 CLINICAL DEVELOPMENT Modified-release Formulation Selected for Clinical Advancement Translational Pharma

May 21, 2014 425

Merger Prospectus - 425

425 1 d729702d425.htm 425 Non-Confidential Investor Presentation Epirus–Zalicus Transaction & Epirus Corporate Overview Filed by Zalicus Inc. Pursuant to Rule 425 under Securities Act of 1933, as amended and deemed filed pursuant to Rule 14a-6 of the Securities Exchange Act of 1934 Subject Company: Zalicus Inc. Registration Statement File No.: 333-195818 Non-Confidential Forward Looking Statement

May 15, 2014 EX-99.1

ZALICUS TO SELL cHTS SERVICE BUSINESS TO HORIZON DISCOVERY GROUP Combination High Throughput Screening Platform and Related Assets Sold for $8 Million

Exhibit 99.1 ZALICUS TO SELL cHTS SERVICE BUSINESS TO HORIZON DISCOVERY GROUP Combination High Throughput Screening Platform and Related Assets Sold for $8 Million CAMBRIDGE, Mass. – May 15, 2014 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today announced that it has entered into an agreeme

May 15, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No.)

May 15, 2014 EX-2.1

ASSET PURCHASE AGREEMENT BY AND AMONG HORIZON DISCOVERY LIMITED, HORIZON DISCOVERY INC., ZALICUS INC. Dated as of May 14, 2014 TABLE OF CONTENTS Page Section 1 - Purchase and Sale of Assets 1 1.1 Sale of Assets 1 1.2 Excluded Assets 3 1.3 Assumption

EX-2.1 Exhibit 2.1 Execution Version ASSET PURCHASE AGREEMENT BY AND AMONG HORIZON DISCOVERY LIMITED, HORIZON DISCOVERY INC., AND ZALICUS INC. Dated as of May 14, 2014 TABLE OF CONTENTS Page Section 1 - Purchase and Sale of Assets 1 1.1 Sale of Assets 1 1.2 Excluded Assets 3 1.3 Assumption of Liabilities 4 1.4 Assignment of Contracts and Rights 6 1.5 Signing and Closing 7 1.6 Purchase Price 7 1.7

May 15, 2014 425

Merger Prospectus - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No.)

May 15, 2014 EX-2.1

ASSET PURCHASE AGREEMENT BY AND AMONG HORIZON DISCOVERY LIMITED, HORIZON DISCOVERY INC., ZALICUS INC. Dated as of May 14, 2014 TABLE OF CONTENTS Page Section 1 - Purchase and Sale of Assets 1 1.1 Sale of Assets 1 1.2 Excluded Assets 3 1.3 Assumption

EX-2.1 Exhibit 2.1 Execution Version ASSET PURCHASE AGREEMENT BY AND AMONG HORIZON DISCOVERY LIMITED, HORIZON DISCOVERY INC., AND ZALICUS INC. Dated as of May 14, 2014 TABLE OF CONTENTS Page Section 1 - Purchase and Sale of Assets 1 1.1 Sale of Assets 1 1.2 Excluded Assets 3 1.3 Assumption of Liabilities 4 1.4 Assignment of Contracts and Rights 6 1.5 Signing and Closing 7 1.6 Purchase Price 7 1.7

May 15, 2014 EX-99.1

ZALICUS TO SELL cHTS SERVICE BUSINESS TO HORIZON DISCOVERY GROUP Combination High Throughput Screening Platform and Related Assets Sold for $8 Million

EX-99.1 3 d726127dex991.htm EX-99.1 Exhibit 99.1 ZALICUS TO SELL cHTS SERVICE BUSINESS TO HORIZON DISCOVERY GROUP Combination High Throughput Screening Platform and Related Assets Sold for $8 Million CAMBRIDGE, Mass. – May 15, 2014 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today announced

May 12, 2014 425

Merger Prospectus - 425

425 1 d724836d425.htm 425 Filed by Zalicus Inc. Pursuant to Rule 425 under Securities Act of 1933, as amended and deemed filed pursuant to Rule 14a-6 of the Securities Exchange Act of 1934 Subject Company: Zalicus Inc. Registration Statement File No.: 333-195818 May 12, 2014 We are working with Epirus Biopharmaceuticals, Inc. (Epirus) to advise them on a merger agreement with Zalicus Inc. (Nasdaq:

May 9, 2014 EX-99.1

ZALICUS REPORTS FINANCIAL RESULTS FOR THE FIRST QUARTER 2014

EX-99.1 Exhibit 99.1 ZALICUS REPORTS FINANCIAL RESULTS FOR THE FIRST QUARTER 2014 CAMBRIDGE, Mass. – May 9, 2014 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today reported financial results for the first quarter ended March 31, 2014. “This was a significant quarter for Zalicus as we announc

May 9, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File

May 9, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

10-Q 1 d705474d10q.htm FORM 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2014. Or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

May 9, 2014 DEFA14A

- DEFA 14A

DEFA 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)

May 8, 2014 EX-99.6

CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR

EX-99.6 Exhibit 99.6 CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR The undersigned hereby consents to be named in the Registration Statement on Form S-4 to which this Consent has been filed as an exhibit, or any amendment thereto, as a person who shall become a Director of Zalicus Inc., such appointment to become effective upon consummation of the merger, as described in the Registrat

May 8, 2014 EX-10.1

AMENDMENT NO. 1 AGREEMENT AND PLAN OF MERGER AND REORGANIZATION

EX-10.1 Exhibit 10.1 Execution Version AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER AND REORGANIZATION This AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER AND REORGANIZATION (this “Amendment”) is made as of May 7, 2014, by and between Zalicus Inc., a Delaware corporation (“Phoenix”), and Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not def

May 8, 2014 EX-99.7

CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR

Exhibit 99.7 CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR The undersigned hereby consents to be named in the Registration Statement on Form S-4 to which this Consent has been filed as an exhibit, or any amendment thereto, as a person who shall become a Director of Zalicus Inc., such appointment to become effective upon consummation of the merger, as described in the Registration Stat

May 8, 2014 EX-99.3

THIS SPECIAL MEETING PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED.

EX-99.3 8 d712283dex993.htm EX-99.3 EXHIBIT 99.3 EPIRUS BIOPHARMACEUTICALS, INC. ATTN: EDWARD SCOTT 699 BOYLSTON ST. 11th FLOOR BOSTON, MA 02116 VOTE BY INTERNET - [www.proxyvote.com] Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 P.M. Eastern Time the day before [special meeting date]. Have your proxy card in hand when you access th

May 8, 2014 EX-10.6

EPIRUS BIOPHARMACEUTICALS, INC. 2011 EQUITY INCENTIVE PLAN STOCK OPTION AGREEMENT

EX-10.6 3 d712283dex106.htm EX-10.6 EXHIBIT 10.6 EPIRUS BIOPHARMACEUTICALS, INC. 2011 EQUITY INCENTIVE PLAN STOCK OPTION AGREEMENT Unless otherwise defined herein, the terms defined in the 2011 Equity Incentive Plan (the “Plan”) shall have the same defined meanings in this Stock Option Agreement (the “Option Agreement”). I. NOTICE OF STOCK OPTION GRANT Name: «Name» Address: «Address» «CityStateZip

May 8, 2014 EX-10.1

AMENDMENT NO. 1 AGREEMENT AND PLAN OF MERGER AND REORGANIZATION

EX-10.1 2 d722832dex101.htm EX-10.1 Exhibit 10.1 Execution Version AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER AND REORGANIZATION This AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER AND REORGANIZATION (this “Amendment”) is made as of May 7, 2014, by and between Zalicus Inc., a Delaware corporation (“Phoenix”), and Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”). Capita

May 8, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 d722832d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514

May 8, 2014 EX-10.5

FOURTEEN22, INC. 2011 EQUITY INCENTIVE PLAN

EX-10.5 EXHIBIT 10.5 FOURTEEN22, INC. 2011 EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are: • to attract and retain the best available personnel for positions of substantial responsibility, • to provide additional incentive to Employees, Directors and Consultants, and • to promote the success of the Company’s business. The Plan permits the grant of Incentive Stock Opti

May 8, 2014 425

Merger Prospectus - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File

May 8, 2014 EX-99.2

FORM OF PROXY ZALICUS INC. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS 2014 Annual Meeting of Stockholders To Be Held On , 2014 at a.m., local time

EX-99.2 EXHIBIT 99.2 FORM OF PROXY ZALICUS INC. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS 2014 Annual Meeting of Stockholders To Be Held On , 2014 at a.m., local time The undersigned stockholder of Zalicus Inc. (the “Company”) hereby acknowledges receipt of the Notice of 2014 Annual Meeting of Stockholders and the Joint Proxy Statement/Prospectus, each dated , 2014, and hereby ap

May 8, 2014 EX-99.8

CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR

EX-99.8 Exhibit 99.8 CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR The undersigned hereby consents to be named in the Registration Statement on Form S-4 to which this Consent has been filed as an exhibit, or any amendment thereto, as a person who shall become a Director of Zalicus Inc., such appointment to become effective upon consummation of the merger, as described in the Registrat

May 8, 2014 S-4

- FORM S-4

S-4 1 d712283ds4.htm FORM S-4 Table of Contents As filed with the Securities and Exchange Commission on May 8, 2014 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ZALICUS INC. (Exact name of registrant as specified in its charter) Delaware 2834 04-3514457 (State or other jurisdiction of

May 8, 2014 EX-99.5

CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR

EX-99.5 Exhibit 99.5 CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR The undersigned hereby consents to be named in the Registration Statement on Form S-4 to which this Consent has been filed as an exhibit, or any amendment thereto, as a person who shall become a Director of Zalicus Inc., such appointment to become effective upon consummation of the merger, as described in the Registrat

May 8, 2014 EX-99.4

CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR

EX-99.4 9 d712283dex994.htm EX-99.4 Exhibit 99.4 CONSENT TO BE NAMED AS A PERSON ABOUT TO BECOME A DIRECTOR The undersigned hereby consents to be named in the Registration Statement on Form S-4 to which this Consent has been filed as an exhibit, or any amendment thereto, as a person who shall become a Director of Zalicus Inc., such appointment to become effective upon consummation of the merger, a

April 30, 2014 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2013. Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commiss

April 16, 2014 EX-2.1

AGREEMENT AND PLAN OF MERGER AND REORGANIZATION ZALICUS INC., a Delaware corporation; BRUNNING, INC., a Delaware corporation; and EPIRUS BIOPHARMACEUTICALS, INC., a Delaware corporation Dated as of April 15, 2014 TABLE OF CONTENTS Page Section 1. DES

EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER AND REORGANIZATION among: ZALICUS INC., a Delaware corporation; BRUNNING, INC., a Delaware corporation; and EPIRUS BIOPHARMACEUTICALS, INC., a Delaware corporation Dated as of April 15, 2014 TABLE OF CONTENTS Page Section 1. DESCRIPTION OF TRANSACTION 2 1.1 Structure of the Merger 2 1.2 Effects of the Merger 2 1.3 Closing; Effective Time 2 1.4 Certif

April 16, 2014 EX-10.1

VOTING AGREEMENT

EX-10.1 Exhibit 10.1 VOTING AGREEMENT THIS VOTING AGREEMENT (“Agreement”), dated as of April 15, 2014, is made by and among Zalicus Inc., a Delaware corporation (“Zalicus”), Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of Zalicus. WHEREAS, Zalicus, BRunning, Inc., a Delaware corporation

April 16, 2014 425

Merger Prospectus - RULE 425

Rule 425 Zalicus & Epirus Investor Call April 16, 2014 8:30AM Filed by Zalicus Inc.

April 16, 2014 EX-10.1

VOTING AGREEMENT

EX-10.1 Exhibit 10.1 VOTING AGREEMENT THIS VOTING AGREEMENT (“Agreement”), dated as of April 15, 2014, is made by and among Zalicus Inc., a Delaware corporation (“Zalicus”), Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of Zalicus. WHEREAS, Zalicus, BRunning, Inc., a Delaware corporation

April 16, 2014 EX-10.2

VOTING AGREEMENT

EX-10.2 Exhibit 10.2 VOTING AGREEMENT THIS VOTING AGREEMENT (“Agreement”), dated as of April 15, 2014, is made by and among Zalicus Inc., a Delaware corporation (“Phoenix”), Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of the Company. WHEREAS, Phoenix, BRunning, Inc., a Delaware corpora

April 16, 2014 EX-99.1

2

EX-99.1 5 d711860dex991.htm EX-99.1 Exhibit 99.1 Press Release Zalicus and Epirus Announce Merger Agreement • Merger will Create a Publicly Traded, Global Biosimilar Enterprise Focused on Improving Patient Access to Important Medicines • Epirus Closes $36 Million Series B Financing Round • Management to Hold Conference Call at 8:30 A.M. EDT BOSTON—(BUSINESS WIRE)—Apr. 16, 2014—Zalicus Inc. (Nasdaq

April 16, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No

April 16, 2014 EX-2.1

AGREEMENT AND PLAN OF MERGER AND REORGANIZATION ZALICUS INC., a Delaware corporation; BRUNNING, INC., a Delaware corporation; and EPIRUS BIOPHARMACEUTICALS, INC., a Delaware corporation Dated as of April 15, 2014 TABLE OF CONTENTS Page Section 1. DES

EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER AND REORGANIZATION among: ZALICUS INC., a Delaware corporation; BRUNNING, INC., a Delaware corporation; and EPIRUS BIOPHARMACEUTICALS, INC., a Delaware corporation Dated as of April 15, 2014 TABLE OF CONTENTS Page Section 1. DESCRIPTION OF TRANSACTION 2 1.1 Structure of the Merger 2 1.2 Effects of the Merger 2 1.3 Closing; Effective Time 2 1.4 Certif

April 16, 2014 425

Merger Prospectus - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No.) (

April 16, 2014 EX-10.2

VOTING AGREEMENT

EX-10.2 Exhibit 10.2 VOTING AGREEMENT THIS VOTING AGREEMENT (“Agreement”), dated as of April 15, 2014, is made by and among Zalicus Inc., a Delaware corporation (“Phoenix”), Epirus Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of the Company. WHEREAS, Phoenix, BRunning, Inc., a Delaware corpora

April 16, 2014 EX-99.1

2

EX-99.1 Exhibit 99.1 Press Release Zalicus and Epirus Announce Merger Agreement • Merger will Create a Publicly Traded, Global Biosimilar Enterprise Focused on Improving Patient Access to Important Medicines • Epirus Closes $36 Million Series B Financing Round • Management to Hold Conference Call at 8:30 A.M. EDT BOSTON—(BUSINESS WIRE)—Apr. 16, 2014—Zalicus Inc. (Nasdaq Capital Market: ZLCS) (Zali

April 1, 2014 EX-99.1

ZALICUS to Present at AACR 2014 Annual Meeting Zalicus and Collaborators Eisai and Sanofi Leverage Combination High-Throughput Screening Platform to Evaluate Combination Drug Synergies

EX-99.1 Exhibit 99.1 ZALICUS to Present at AACR 2014 Annual Meeting Zalicus and Collaborators Eisai and Sanofi Leverage Combination High-Throughput Screening Platform to Evaluate Combination Drug Synergies CAMBRIDGE, Mass. – April 1, 2014 – Zalicus Inc. (Nasdaq Global Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today ann

April 1, 2014 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No.) (I

March 14, 2014 EX-21.1

Subsidiaries of Zalicus Inc.

EX-21.1 Exhibit 21.1 Subsidiaries of Zalicus Inc. Zalicus Pharmaceuticals Ltd.—formed in British Columbia

March 14, 2014 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

10-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 13, 2014 EX-99

ZALICUS REPORTS FINANCIAL RESULTS FOR THE FOURTH QUARTER AND YEAR-END 2013

DC14236.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS REPORTS FINANCIAL RESULTS FOR THE FOURTH QUARTER AND YEAR-END 2013 Provides Update on Operations CAMBRIDGE, Mass. – March 13, 2014 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today

March 13, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 rrd405380.htm ZALICUS FORM 8-K AND PRESS RELEASE EXHIBIT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction

February 7, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K 1 rrd401826.htm ZALICUS FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 3, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-5

February 3, 2014 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition, Completion of Acquisition or Disposition of Assets - ZALICUS FORM 8-K

UNITED STATES UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 31, 2014 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commis

February 3, 2014 EX-10

(xxxiii)“Third Party Claim” has the meaning set forth in Section 7.5 below. (xxxiv)“Transaction Documents” means this Agreement, the Bill of Sale and all of the other agreements, documents, letters and certificates executed or delivered in connection

DC14138.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ROYALTY PURCHASE AGREEMENT BY AND BETWEEN MALLINCKRODT MEDICAL IMAGING - IRELAND AND ZALICUS PHARMACEUTICALS LTD. DATED AS OF JANUARY 31, 2014 1 THIS ROYALTY PURCHASE AGREEMENT dated as of January 31, 2014 (“Agreement”), is made by and between ZALICUS PHARMACEUTICALS LTD., formerly known as Neuromed Phar

November 12, 2013 8-K

Financial Statements and Exhibits, Other Events

8-K 1 rrd394994.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 11, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457

November 12, 2013 EX-99

-Company to Discontinue Z160 Clinical Development-

DC13961.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS REPORTS RESULTS FROM PHASE 2 CLINICAL TRIALS OF Z160 IN CHRONIC NEUROPATHIC PAIN -Company to Discontinue Z160 Clinical Development- CAMBRIDGE, Mass. – November 11, 2013 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments f

November 4, 2013 EX-99

ZALICUS REPORTS FINANCIAL RESULTS FOR THE THIRD QUARTER 2013

DC13892.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS REPORTS FINANCIAL RESULTS FOR THE THIRD QUARTER 2013 CAMBRIDGE, Mass. – November 4, 2013 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today reported financial results for the third

November 4, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 rrd394165.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (

November 4, 2013 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2013. Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-51

November 1, 2013 EX-99

ZALICUS ANNOUNCES POSITIVE RESULTS OF Z944 PHASE 1B CLINICAL STUDY IN PAIN Efficacy Signals in Inflammatory and Neuropathic Pain Observed Second U.S. Patent Issues for Z944 Providing Exclusivity to 2029

DC13890.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS ANNOUNCES POSITIVE RESULTS OF Z944 PHASE 1B CLINICAL STUDY IN PAIN Efficacy Signals in Inflammatory and Neuropathic Pain Observed Second U.S. Patent Issues for Z944 Providing Exclusivity to 2029 CAMBRIDGE, Mass. – November 1, 2013 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmac

November 1, 2013 8-K

Financial Statements and Exhibits, Other Events -

UNITED STATES UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 1, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commis

October 15, 2013 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits -

UNITED STATES UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 15, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commis

October 15, 2013 EX-99

ZALICUS REGAINS COMPLIANCE WITH NASDAQ LISTING REQUIREMENTS

DC13849.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS REGAINS COMPLIANCE WITH NASDAQ LISTING REQUIREMENTS CAMBRIDGE, Mass. – October 15, 2013 – Zalicus Inc. (the “Company”) today announced that it has received notice from the Listing Qualifications Staff of The Nasdaq Stock Market LLC that the Company has regained compliance with Nasdaq Mark

October 2, 2013 EX-3

CERTIFICATE OF AMENDMENT OF SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ZALICUS INC.

DC13802.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing CERTIFICATE OF AMENDMENT OF SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ZALICUS INC. Zalicus Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify: 1. The name of the Corp

October 2, 2013 EX-99

ZALICUS ANNOUNCES 1-FOR-6 REVERSE STOCK SPLIT

DC13795.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS ANNOUNCES 1-FOR-6 REVERSE STOCK SPLIT CAMBRIDGE, Mass. – October 2, 2013 – Zalicus Inc. (Nasdaq Capital Market: ZLCS) today announced that it has filed a Certificate of Amendment to its Sixth Amended and Restated Certificate of Incorporation, with the Secretary of State of the State of De

October 2, 2013 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 2, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Commission File No.)

September 27, 2013 EX-99

ZALICUS’ Z160 RECEIVES ORPHAN DRUG DESIGNATION FOR THE MANAGEMENT OF POSTHERPETIC NEURALGIA

DC13788.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS’ Z160 RECEIVES ORPHAN DRUG DESIGNATION FOR THE MANAGEMENT OF POSTHERPETIC NEURALGIA CAMBRIDGE, Mass. – September 27, 2013 – Zalicus Inc. (Nasdaq Capital Market: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain, today announce

September 27, 2013 8-K

Financial Statements and Exhibits, Other Events -

UNITED STATES UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 27, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457 (Comm

September 9, 2013 EX-99

Experimental Clinical Study Expected to Complete During the Fourth Quarter 2013

DC13728.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing ZALICUS ZALICUS INITIATES PHASE 1b CLINICAL STUDY OF Z944, ITS NOVEL, ORAL, T-TYPE CALCIUM CHANNEL BLOCKER, FOR THE TREATMENT OF PAIN Experimental Clinical Study Expected to Complete During the Fourth Quarter 2013 CAMBRIDGE, Mass. – September 9, 2013 – Zalicus Inc. (Nasdaq Capital Market: ZLCS) a biophar

September 9, 2013 8-K

Financial Statements and Exhibits, Other Events

8-K 1 rrd389911.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457

September 3, 2013 8-K

Financial Statements and Exhibits, Other Events

8-K 1 rrd389535.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 3, 2013 ZALICUS INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 000-51171 04-3514457

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