ATOS / Atossa Therapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Atossa Therapeutics, Inc.
US ˙ NasdaqCM ˙ US04962H5063

Mga Batayang Estadistika
LEI 549300QRKP1JTNHD2366
CIK 1488039
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Atossa Therapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 21, 2025 8-K

FORM 8-K Item 3.01 Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissi

August 12, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 12, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissi

August 12, 2025 EX-99.1

Atossa Therapeutics Announces Second Quarter 2025 Financial Results and Provides a Corporate Update FDA Provides Positive Feedback, Clears Path for Atossa to File IND for (Z)-Endoxifen in Metastatic Breast Cancer; FDA Indicates No Additional Toxicity

Exhibit 99.1 Atossa Therapeutics Announces Second Quarter 2025 Financial Results and Provides a Corporate Update FDA Provides Positive Feedback, Clears Path for Atossa to File IND for (Z)-Endoxifen in Metastatic Breast Cancer; FDA Indicates No Additional Toxicity Studies Required Strong I-SPY2 Results Reinforce Efficacy of Atossa’s Monotherapy at 3-weeks SEATTLE, August 12, 2025 — Atossa Therapeut

August 12, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from XXXXXXXX XX, XXXX to XXXXXXXX XX, XXXX Commission File Number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 13, 2025 EX-99.1

Atossa Therapeutics Announces First Quarter 2025 Financial Results and Provides a Corporate Update Announced strategic plan to advance (Z)-endoxifen for metastatic breast cancer indication Enhanced (Z)-endoxifen intellectual property portfolio with t

Exhibit 99.1 Atossa Therapeutics Announces First Quarter 2025 Financial Results and Provides a Corporate Update Announced strategic plan to advance (Z)-endoxifen for metastatic breast cancer indication Enhanced (Z)-endoxifen intellectual property portfolio with three new U.S. patents, expanding IP portfolio to more than 200 patent claims related to (Z)-endoxifen Ended first quarter 2025 with $65.1

May 13, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commission

May 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from XXXXXXXX XX, XXXX to XXXXXXXX XX, XXXX Commission File Number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 12, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commission F

April 7, 2025 8-K

FORM 8-K Item 8.01 Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 7, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commission

March 26, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

March 26, 2025 S-8

As filed with the Securities and Exchange Commission on March 26, 2025

As filed with the Securities and Exchange Commission on March 26, 2025 Registration No.

March 26, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-8 Atossa Therapeutics, Inc. Table 1 – Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, $0.18 par value 457(a) 12,000,000 $0.725(2) $8,700,000(2) $153.10 per $1,0

March 25, 2025 EX-99.1

Atossa Therapeutics Announces Full Year 2024 Financial Results and Provides Corporate Update Ended 2024 with $71.1 million of cash and cash equivalents and no debt Conference Call and Webcast Scheduled for Tuesday, March 25, 2025, at 8:30 a.m. Easter

EX-99.1 2 atos-ex991.htm EX-99.1 Exhibit 99.1 Atossa Therapeutics Announces Full Year 2024 Financial Results and Provides Corporate Update Ended 2024 with $71.1 million of cash and cash equivalents and no debt Conference Call and Webcast Scheduled for Tuesday, March 25, 2025, at 8:30 a.m. Eastern Time SEATTLE, March 25, 2025 - Atossa Therapeutics, Inc. (Nasdaq: ATOS) (“Atossa” or the “Company”), a

March 25, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 25, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissio

March 25, 2025 EX-21.1

List of Subsidiaries

Exhibit 21.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

March 25, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ☒ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2024 OR ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number: 001-3

March 25, 2025 EX-19.1

Insider Trading Policy

Exhibit 19.1 ATOSSA THERAPEUTICS, INC. STATEMENT OF COMPANY POLICY ON INSIDER TRADING AND DISCLOSURE This memorandum sets forth the policy of Atossa Therapeutics, Inc. (the “Company”) regarding trading in the Company’s securities as described below and the disclosure of information concerning the Company. This Statement of Company Policy on Insider Trading and Disclosure (the “Insider Trading Poli

March 25, 2025 EX-4.6

Description of Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934.

Exhibit 4.6 DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 The following is a description of the authorized capital stock of Atossa Therapeutics, Inc. (the “Company” or “we” or “our”). The following description of our common stock is a summary and does not purport to be complete. It is subject to and qualified in its entirety by

March 12, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 11, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissio

March 12, 2025 EX-99.1

Atossa Therapeutics Announces Plans to Pursue Metastatic Breast Cancer Indication for (Z)-Endoxifen and Continued Engagement with FDA on Additional Indications

Exhibit 99.1 Atossa Therapeutics Announces Plans to Pursue Metastatic Breast Cancer Indication for (Z)-Endoxifen and Continued Engagement with FDA on Additional Indications SEATTLE, March 11, 2025 – Atossa Therapeutics, Inc. (Nasdaq: ATOS) (“Atossa” or the “Company”), a clinical-stage biopharmaceutical company dedicated to the prevention and treatment of breast cancer, today announced its strategi

February 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 21, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commis

February 4, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2025 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commiss

February 4, 2025 EX-99.1

Atossa Therapeutics Responds to PTAB Ruling on U.S. Patent No. 11,572,334 and Announces the Issuance of U.S. Patent No. 12,201,591

Exhibit 99.1 Atossa Therapeutics Responds to PTAB Ruling on U.S. Patent No. 11,572,334 and Announces the Issuance of U.S. Patent No. 12,201,591 SEATTLE, January 30, 2025 - Atossa Therapeutics, Inc. (Nasdaq: ATOS) (“Atossa” or the “Company”), a clinical-stage biopharmaceutical company dedicated to the prevention and treatment of breast cancer, today issued the following statement in response to the

December 10, 2024 EX-99.1

Atossa Therapeutics to Present Pharmacokinetic and Tolerability Data from Phase 2 EVANGELINE Trial at the 2024 San Antonio Breast Cancer Symposium

Atossa Therapeutics to Present Pharmacokinetic and Tolerability Data from Phase 2 EVANGELINE Trial at the 2024 San Antonio Breast Cancer Symposium SEATTLE, December 10, 2024 - Atossa Therapeutics, Inc.

December 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 10, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commis

November 19, 2024 424B5

Up to $100,000,000 Common Stock

Filed Pursuant to Rule 424(b)(5)  Registration No. 333-279367 PROSPECTUS SUPPLEMENT Up to $100,000,000 Common Stock We have entered into an Open Market Sale AgreementSM (the “Sale Agreement”) with Jefferies LLC (“Jefferies” or the “Sales Agent”) relating to shares of our common stock, $0.18 par value per share. Under this prospectus supplement and the accompanying prospectus, and in accordance wit

November 19, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 19, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commis

November 19, 2024 EX-1.1

Open Market Sale Agreement SM, dated November 19, 2024, by and between Atossa Therapeutics, Inc. and Jefferies LLC

Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM November 19, 2024 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Atossa Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s com

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from XXXXXXXX XX, XXXX to XXXXXXXX XX, XXXX Commission File Number: 001-35610 ATOSSA THERAPEUTICS, INC.

November 12, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commis

November 12, 2024 EX-99.1

Atossa Therapeutics Announces Third Quarter 2024 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Third Quarter 2024 Financial Results and Provides Corporate Update • Announced positive topline results from KARISMA-Endoxifen Phase 2 study which demonstrated that low doses of (Z)-endoxifen significantly reduced mammographic breast density (MBD), addressing a key breast cancer risk factor • Released a preliminary analysis from I-SPY 2 Endocrine Optimiza

November 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commiss

November 4, 2024 EX-99.1

Atossa Therapeutics Reports Positive KARISMA-Endoxifen Trial Results: (Z)-Endoxifen Shown to Significantly Reduce Mammographic Breast Density, Potentially Paving the Way for Innovative Cancer Prevention Strategies

Exhibit 99.1 Atossa Therapeutics Reports Positive KARISMA-Endoxifen Trial Results: (Z)-Endoxifen Shown to Significantly Reduce Mammographic Breast Density, Potentially Paving the Way for Innovative Cancer Prevention Strategies SEATTLE, November 4, 2024 - Atossa Therapeutics, Inc. (Nasdaq: ATOS) ("Atossa" or the "Company"), a clinical-stage biopharmaceutical company developing innovative medicines

August 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 12, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissi

August 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from XXXXXXXX XX, XXXX to XXXXXXXX XX, XXXX Commission File Number: 001-35610 ATOSSA THERAPEUTICS, INC.

August 12, 2024 EX-10.2

Employment Agreement with Heather Rees Dated July 1, 2024

Exhibit 10.2 EMPLOYMENT AGREEMENT This EMPLOYMENT AGREEMENT (the “Agreement”) is entered into as of July 1, 2024 (the “Effective Date”), by and between Atossa Therapeutics Inc. (the “Company”) and Heather Rees (“Executive”). WHEREAS, the Company wishes to employ Executive as the Chief Financial Officer of the Company and Executive wishes to work in such capacity; and WHEREAS, the Company and Execu

August 12, 2024 EX-99.1

For the Three Months Ended June 30,

Exhibit 99.1 Atossa Therapeutics Announces Second Quarter 2024 Financial Results and Provides Corporate Update • Presented data showing 100% disease control rate after 24-week treatment with (Z)-Endoxifen in 40mg cohort of Phase 2 EVANGELINE study at the American Association for Cancer Research (AACR) Annual Meeting • Completed enrollment in 80mg PK Run-in Cohort for EVANGELINE trial • Completed P

July 2, 2024 EX-3.1

Certificate of Amendment to Amended and Restated Certificate of Incorporation

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ATOSSA THERAPEUTICS, INC. Atossa Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), hereby certifies as follows: FIRST: That the current name of the Corporation is Atossa Therapeutics, Inc., and the Corporation was originally incorporat

July 2, 2024 EX-10.1

2020 Stock Incentive Plan, as Amended

Exhibit 10.1 ATOSSA THERAPEUTICS, INC. 2020 STOCK INCENTIVE PLAN (Most Recently Amended effective as of June 27, 2024) SECTION 1. GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the Atossa Therapeutics, Inc. 2020 Stock Incentive Plan (the “Plan”). The purpose of the Plan is to encourage and enable the officers, employees, Non-Employee Directors and other key persons (including Con

July 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commission

May 23, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

May 21, 2024 CORRESP

107 Spring Street, Seattle, WA 98104

May 21, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

May 14, 2024 DEL AM

May 14, 2024

May 14, 2024 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

May 13, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commission

May 13, 2024 EX-4.1

Form of Senior Indenture

Exhibit 4.1 ATOSSA THERAPEUTICS, INC. Debt Securities Indenture Dated as of [ ] [ ]., as Trustee CROSS-REFERENCE TABLE This Cross-Reference Table is not a part of the Indenture TIA Section Indenture Section 310(a)(1) 7.10 (a)(2) 7.10 (a)(3) N.A. (a)(4) N.A. (b) 7.08; 7.10; 12.02 311(a) 7.11 (b) 7.11 (c) N.A. 312(a) 2.05 (b) 12.03 (c) 12.03 313(a) 7.06 (b)(1) N.A. (b)(2) 7.06 (c) 12.02 (d) 7.06 314

May 13, 2024 S-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 ATOSSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter)

As filed with the Securities and Exchange Commission on May 13, 2024 Registration Statement No.

May 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from XXXXXXXX XX, XXXX to XXXXXXXX XX, XXXX Commission File Number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 13, 2024 EX-FILING FEES

Filing Fee Table

Calculation of Filing Fee Tables Form S-3 (Form Type) Atossa Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry For

May 13, 2024 EX-99.1

Atossa Therapeutics Announces First Quarter 2024 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces First Quarter 2024 Financial Results and Provides Corporate Update • Presented data from EVANGELINE study showing 100% disease control rate at 24-weeks • Initiated study evaluating (Z)-endoxifen in combination with abemaciclib (VERZENIO®) • Ended first quarter 2024 with $84.0 million of cash and cash equivalents and no debt SEATTLE, May 13, 2024— Atossa T

May 10, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 2, 2024 EX-99.1

Atossa Therapeutics Announces Year-End 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Year-End 2023 Financial Results and Provides Corporate Update • Fully enrolled two Phase 2 studies with data from both expected in the second half of 2024 • First patient dosed in new Phase 2 breast cancer prevention study • Data from ongoing Phase 2 EVANGELINE study scheduled to be presented at 2024 AACR Annual Meeting • Ended 2023 with $88.5 million of

April 2, 2024 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissi

April 1, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ☒ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2023 OR ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number: 001-3

April 1, 2024 EX-21.1

List of Subsidiaries

Exhibit 21.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

April 1, 2024 EX-97.1

Incentive Compensation Clawback Policy

Exhibit 97.1 INCENTIVE COMPENSATION CLAWBACK POLICY Recoupment of Incentive-Based Compensation It is the policy of Atossa Therapeutics, Inc. (the “Company”) that, in the event the Company is required to prepare an accounting restatement of the Company’s financial statements due to material non-compliance with any financial reporting requirement under the federal securities laws (including any such

April 1, 2024 EX-10.13

Employment Letter with Heather Rees Dated October 6, 2023

EXHIBIT 10.13 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential. October 6, 2023 Heather Rees [*] *Delivered via email Dear Heather, A significant factor in our success at Atossa Therapeutics is our people and the effort and talent the

April 1, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commission

April 1, 2024 EX-10.12

Employment Agreement with Greg Weaver Dated June 1, 2023

Exhibit 10.12 EMPLOYMENT AGREEMENT This EMPLOYMENT AGREEMENT (the “Agreement”) is entered into as of June 1, 2023 (the “Effective Date”), by and between Atossa Therapeutics Inc. (the “Company”) and Gregory Weaver (“Executive”). WHEREAS, the Company wishes to employ Executive as the Executive Vice President and Chief Financial Officer of the Company and Executive wishes to work in such capacity; an

April 1, 2024 EX-99.1

Atossa Therapeutics Announces Year-End 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Year-End 2023 Financial Results and Provides Corporate Update • Fully enrolled two Phase 2 studies with data from both expected in the second half of 2024 • First patient dosed in new Phase 2 breast cancer prevention study • Data from ongoing Phase 2 EVANGELINE study scheduled to be presented at 2024 AACR Annual Meeting • Ended 2023 with $88.5 million of

March 18, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissio

March 12, 2024 EX-99.1

Atossa Therapeutics Appoints Breast Cancer Specialist Tessa Cigler, M.D., M.P.H. to its Board of Directors

EXHIBIT 99.1 Atossa Therapeutics Appoints Breast Cancer Specialist Tessa Cigler, M.D., M.P.H. to its Board of Directors SEATTLE, March 12, 2024 — Atossa Therapeutics, Inc. (Nasdaq: ATOS) (“Atossa” or the “Company”), a clinical stage biopharmaceutical company developing innovative medicines in areas of significant unmet medical need in oncology with a focus on breast cancer, today announced that Te

March 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 09, 2024 Atossa Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-35610 26-4753208 (State or Other Jurisdiction of Incorporation) (Commissio

November 13, 2023 EX-99.1

Atossa Therapeutics Announces Third Quarter 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Third Quarter 2023 Financial Results and Provides Corporate Update ● Achieved significant enrollment milestones in ongoing Phase 2 clinical trials ● Four ongoing Phase 2 studies evaluating (Z)-endoxifen, including recently announced study in DCIS ● Ended third quarter 2023 with $94.0 million of cash and cash equivalents SEATTLE, November 13, 2023 (GLOBE N

November 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2023 Atossa Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commis

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSS

November 9, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 9, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commiss

October 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 6, 2023 (October 2, 2023)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 6, 2023 (October 2, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorp

September 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 28, 2023 (September 26,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 28, 2023 (September 26, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of

August 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: August 30, 2023 Atossa Therapeutics, Inc. (Exact name of registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: August 30, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S. Employer I

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

August 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 14, 2023 Atossa Therapeuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 14, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissi

August 14, 2023 EX-99.1

Atossa Therapeutics Announces Second Quarter 2023 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Atossa Therapeutics Announces Second Quarter 2023 Financial Results and Provides Corporate Update ● Achieved significant enrollment milestones in three ongoing Phase 2 clinical trials ● Broadened patent protection for proprietary (Z)-endoxifen ● Strengthened management team with appointment of Greg Weaver as Chief Financial Officer ● Ended second quarter 2023 with $99.4 million of cas

July 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 13, 2023 (July 13, 2023) Ato

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 13, 2023 (July 13, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporat

June 28, 2023 EX-99.1

Atossa Therapeutics Announces $10M Stock Repurchase Program

Exhibit 99.1 Atossa Therapeutics Announces $10M Stock Repurchase Program SEATTLE, June 27, 2023 (GLOBE NEWSWIRE) — Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical stage biopharmaceutical company developing innovative proprietary medicines to address significant unmet needs in oncology with a focus on breast cancer, today announces that its Board of Directors has approved a share repurchase pr

June 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 28, 2023 (June 27, 2023) Ato

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 28, 2023 (June 27, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporat

June 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 23, 2023 (June 21, 2023) Ato

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 23, 2023 (June 21, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporat

June 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 1, 2023 (May 26, 2023) Atoss

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 1, 2023 (May 26, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporatio

May 22, 2023 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 22, 2023 (May 17, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporatio

May 22, 2023 EX-16.1

Letter from BDO USA LLP, dated May 22, 2023

Exhibit 16.1 May 22, 2023 Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on May 17, 2023, to be filed by our former client, Atossa Therapeutics, Inc. We agree with the statements made in response to that Item insofar as they relate to our Firm. Very truly yours, /s/

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 15, 2023 EX-99.1

Atossa Therapeutics Announces First Quarter 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces First Quarter 2023 Financial Results and Provides Corporate Update ● Two Phase 2 trials investigating (Z)-endoxifen in neoadjuvant setting initiated and are enrolling patients ● Full enrollment of Phase 2 KARISMA mammographic breast density study expected by end of 2023 ● Ended first quarter 2023 with $103.9 million of cash and cash equivalents and no deb

May 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 15, 2023 Atossa Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 15, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

May 4, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 4, 2023 (May 4, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation)

April 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 26, 2023 Atossa Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 26, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissio

April 26, 2023 EX-3.2

Amended and Restated Bylaws

Exhibit 3.2 AMENDED AND RESTATED BY-LAWS OF ATOSSA THERAPEUTICS, INC. (the “Corporation”) ARTICLE I Stockholders SECTION 1. Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these By-laws as an “Annual Meeting”) shall be held at the hour, date and place within or without the United States which is fixed by the Board of Directors, which time, date and place m

April 26, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.1) Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 4, 2023 (April 4, 2023) Ato

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 4, 2023 (April 4, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporat

March 30, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.  ) Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☑ Defi

March 22, 2023 EX-99.1

Period-Period Change

EXHIBIT 99.1 Atossa Therapeutics Announces Year-End 2022 Financial Results and Provides Corporate Update SEATTLE, March 22, 2023 (GLOBE NEWSWIRE) — Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical stage biopharmaceutical company developing innovative proprietary medicines to address significant unmet needs in cancer, today announced financial results for the fiscal quarter and fiscal year ende

March 22, 2023 EX-10.3

Form of Indemnification Agreement

EXHIBIT 10.3 ATOSSA THERAPEUTICS, INC. INDEMNIFICATION AGREEMENT This Indemnification Agreement (“Agreement”) is made effective as of January 6, 2020 (the “Effective Date”) by and between Atossa Therapeutics, Inc., a Delaware corporation (the “Company”), and (“Indemnitee”). RECITALS WHEREAS, the Company, which is organized under the General Corporation Law of the State of Delaware (“DGCL”), wishes

March 22, 2023 EX-21.1

List of Subsidiaries

Exhibit 21.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

March 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 22, 2023 Atossa Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 22, 2023 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissio

March 22, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ☒ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2022 OR ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number: 001-35610 ATOSSA THERAP

March 13, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 13, 2023 (March 10, 2023) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorpor

February 9, 2023 SC 13G/A

ATOS / Atossa Therapeutics Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 1)* Name of issuer: Atossa Therapeutics Inc. Title of Class of Securities: Common Stock CUSIP Number: 04962H506 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pursuant to which this Schedule is fil

November 7, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 7, 2022 Atossa Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 7, 2022 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commiss

November 7, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

November 7, 2022 EX-99.1

Atossa Therapeutics Announces Third Quarter 2022 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Atossa Therapeutics Announces Third Quarter 2022 Financial Results and Provides Corporate Update SEATTLE, November 7, 2022 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), today announces financial results for the fiscal quarter ended September 30, 2022, and provides an update on recent company developments. Atossa is a clinical-stage biopharmaceutical company seeking to d

October 7, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 7, 2022 (October 5, 2022) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorp

August 8, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 8, 2022 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissio

August 8, 2022 EX-99.1

Atossa Therapeutics Announces Second Quarter 2022 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Second Quarter 2022 Financial Results and Provides Corporate Update SEATTLE, August 8, 2022 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to develop innovative proprietary medicines in oncology and infectious disease with a current focus on breast cancer and COVID-19, today announces financ

August 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

July 7, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 7, 2022 (July 1, 2022) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporatio

July 1, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 1, 2022 (June 28, 2022) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporati

June 6, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 6, 2022 (June 1, 2022) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporatio

May 16, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 16, 2022 (May 13, 2022) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporatio

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 9, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 9, 2022 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission F

May 9, 2022 EX-99.1

Atossa Therapeutics Announces First Quarter 2022 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces First Quarter 2022 Financial Results and Provides Corporate Update SEATTLE, May 09, 2022 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to develop innovative proprietary medicines in oncology and infectious disease with a current focus on breast cancer and COVID-19, today announces financial

April 11, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 1, 2022 PRE 14A

PRELIMINARY PROXY STATEMENT – SUBJECT TO COMPLETION UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

PRELIMINARY PROXY STATEMENT ? SUBJECT TO COMPLETION UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

February 28, 2022 EX-99.1

Atossa Therapeutics Announces Year-End 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Year-End 2021 Financial Results and Provides Corporate Update SEATTLE, February 28, 2022 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to develop innovative medicines in oncology and infectious disease with a current focus on breast cancer and COVID-19, today announces financial results for

February 28, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ? Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2021 OR ? Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number 001-35

February 28, 2022 EX-22.1

List of Subsidiaries

Exhibit 22.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

February 28, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): February 28, 2022 (February 24, 2022) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of in

February 14, 2022 SC 13G/A

ATOS / Atossa Therapeutics Inc / CVI Investments, Inc. - SC 13G/A Passive Investment

CUSIP No: 04962H506 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO ? 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO ? 240.13d-2. (Amendment No. 1)* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Num

February 9, 2022 SC 13G

ATOS / Atossa Therapeutics Inc / VANGUARD GROUP INC - SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 Name of issuer: Atossa Therapeutics Inc. Title of Class of Securities: Common Stock CUSIP Number: 04962H506 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rule 13d-1(b)

January 13, 2022 SC 13G/A

ATOS / Atossa Therapeutics Inc / Empery Asset Management, LP - ATOSSA THERAPEUTICS, INC. Passive Investment

SC 13G/A 1 p22-0101sc13ga.htm ATOSSA THERAPEUTICS, INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.18 (Title of Class of Securities) 04962H506 (CUSIP Number) December 31, 2021 (Date of event which requires filing of this statement) Check the

November 15, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 15, 2021 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commis

November 15, 2021 EX-99.1

Atossa Therapeutics Announces Third Quarter 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Third Quarter 2021 Financial Results and Provides Corporate Update SEATTLE, November 15, 2021 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to develop innovative proprietary medicines in oncology and infectious disease with a current focus on breast cancer and COVID-19, today announces fina

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

October 6, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 6, 2021 (October 6, 2021) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorp

September 14, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

September 8, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 8, 2021 (September 7, 2021) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of in

August 13, 2021 EX-99.1

Atossa Therapeutics Announces Second Quarter 2021 Financial Results - Provides Corporate Update and Information about Upcoming Stockholder Meeting

Exibit 99.1 Atossa Therapeutics Announces Second Quarter 2021 Financial Results - Provides Corporate Update and Information about Upcoming Stockholder Meeting SEATTLE, August 13, 2021 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in oncology and infectious disease with a current focus on

August 13, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 13, 2021 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissi

August 13, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

August 9, 2021 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

July 29, 2021 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

May 18, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 18, 2021 (May 14, 2021) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporatio

May 14, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 14, 2021 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

May 14, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 14, 2021 EX-99.1

Atossa Therapeutics Announces First Quarter 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces First Quarter 2021 Financial Results and Provides Corporate Update SEATTLE, May 14, 2021 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in oncology and infectious disease with a current focus on breast cancer and COVID-19, today announces financia

May 11, 2021 DEFA14A

- FORM DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 27, 2021 CORRESP

VIA EDGAR

VIA EDGAR April 27, 2021 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

April 21, 2021 S-3

- FORM S-3

Table of Contents As filed with the Securities and Exchange Commission on April 21, 2021 Registration Statement No.

April 15, 2021 DEF 14A

- FORM DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 5, 2021 PRE 14A

- FORM PRE 14A

PRE 14A 1 atos20210330pre14a.htm FORM PRE 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☑ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted

March 31, 2021 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ? Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2020 OR ? Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number 001-35

March 31, 2021 EX-99.1

2020 Stock Incentive Plan, as amended

Exhibit 99.1 ATOSSA THERAPEUTICS, INC. 2020 STOCK INCENTIVE PLAN (Amended effective as of March 29, 2021) SECTION 1.GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the Atossa Therapeutics, Inc. 2020 Stock Incentive Plan (the ?Plan?). The purpose of the Plan is to encourage and enable the officers, employees, Non-Employee Directors and other key persons (including Consultants and p

March 31, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 31, 2021 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissio

March 31, 2021 EX-99.1

Atossa Therapeutics Announces Year End 2020 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Year End 2020 Financial Results and Provides Corporate Update SEATTLE, March 31, 2021 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in oncology and infectious disease with a current focus on breast cancer and COVID-19, today announced financial r

March 31, 2021 EX-22.1

List of Subsidiaries

Exhibit 22.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

March 31, 2021 S-8

As filed with the Securities and Exchange Commission on March 31, 2021

As filed with the Securities and Exchange Commission on March 31, 2021 Registration No.

March 23, 2021 424B5

17,361,100 Shares of Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-248555 PROSPECTUS SUPPLEMENT (To Prospectus dated September 10, 2020) 17,361,100 Shares of Common Stock We are offering 17,361,100 shares (the “shares”) of our common stock, par value $0.18 per share (the “common stock”) pursuant to this prospectus supplement and the accompanying prospectus. In a concurrent private placement,

March 23, 2021 EX-1.2

Placement Agency Agreement between Atossa Therapeutics, Inc. and Maxim Group LLC, dated March 22, 2021.

Exhibit 1.2 March 22, 2021 Mr. Steven C. Quay Chief Executive Officer Atossa Therapeutics, Inc. 107 Spring Street Seattle, WA 98104 Dear Mr. Quay: This letter (the ?Agreement?) constitutes the agreement between Maxim Group LLC, a limited liability company formed under the laws of the State of New York (?Maxim? or the ?Placement Agent?) and Atossa Therapeutics, Inc., a company incorporated under th

March 23, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 23, 2021 (March 22, 2021) ATOSSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorpor

March 23, 2021 EX-1.1

Current Report on Form 8-K, as Exhibit 1.1

Exhibit 1.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of March 22, 2021, between Atossa Therapeutics, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms and condition

March 23, 2021 EX-4.1

Form of Warrant

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

March 23, 2021 EX-1.3

Form of Lock-up and Voting Agreement dated March 22, 2021

Exhibit 1.3 LOCK-UP AND VOTING AGREEMENT This Lock-Up and Voting Agreement (this ?Lock-Up and Voting Agreement?) is being delivered to you in connection with that certain Share Purchase Agreement (the ?SPA?) by and between Atossa Therapeutics, Inc., a Delaware corporation (the ?Company?), and the person(s) or entity(ies) named on the signature pages hereto (collectively, the ?Holder?). Reference i

March 22, 2021 S-3MEF

- FORM S-3MEF

As filed with the Securities and Exchange Commission on March 22, 2021 Registration Statement No.

March 22, 2021 8-K

Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 22, 2021 (March 22, 2021) ATOSSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorpor

February 4, 2021 424B2

ATOSSA THERAPEUTICS, INC. 10,500,000 Shares Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(2) File No. 333-252335 PROSPECTUS ATOSSA THERAPEUTICS, INC. 10,500,000 Shares Common Stock This prospectus covers the sale of an aggregate of 10,500,000 shares (the “shares”) of our common stock, $0.18 par value per share (the “common stock”), by the selling stockholders identified in this prospectus (collectively with any of the holder’s transferees

January 28, 2021 CORRESP

-

VIA EDGAR January 28, 2021 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

January 22, 2021 S-3

- FORM S-3

Table of Contents As filed with the Securities and Exchange Commission on January 22, 2021 Registration Statement No.

January 15, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Atos

CUSIP No: 04962H506 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Num

January 15, 2021 SC 13G

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. ___)* At

CUSIP No: 04962H506 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Numb

January 15, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Sec

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Number) January 6, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the r

January 14, 2021 SC 13G

Atossa Therapeutics, Inc.

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.18 (Title of Class of Securities) 04962H506 (CUSIP Number) January 6, 2021 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which th

January 8, 2021 EX-1.1

Securities Purchase Agreement dated January 6, 2021

Exhibit 1.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of January 6, 2021, between Atossa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditio

January 8, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 8, 2021 (January 6, 2021) ATOSSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorp

January 8, 2021 424B3

Units consisting of an Aggregate of 23,850,000 Shares of Common Stock and Warrants Convertible Into 17,887,500 Shares of Common Stock (and the Shares of Common Stock Underlying the Warrants)

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-248555 PROSPECTUS SUPPLEMENT (To Prospectus dated September 10, 2020) Units consisting of an Aggregate of 23,850,000 Shares of Common Stock and Warrants Convertible Into 17,887,500 Shares of Common Stock (and the Shares of Common Stock Underlying the Warrants) We are offering units consisting of an aggregate of 23,850,000 shar

January 8, 2021 EX-1.2

Placement Agency Agreement between Atossa Therapeutics, Inc. and Maxim Group LLC, dated January 6, 2021

Exhibit 1.2 January 6, 2021 Mr. Steven C. Quay Chief Executive Officer Atossa Therapeutics, Inc. 107 Spring Street Seattle, WA 98104 Dear Mr. Quay: This letter (the “Agreement”) constitutes the agreement between Maxim Group LLC, a limited liability company formed under the laws of the State of New York (“Maxim” or the “Placement Agent”) and Atossa Therapeutics, Inc., a company incorporated under t

January 8, 2021 EX-4.1

Form of Warrant

Exhibit 4.1 FORM OF COMMON STOCK PURCHASE WARRANT ATOSSA THERAPEUTICS, INC. Warrant Shares: [] Initial Exercise Date: [], 2021 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (th

December 28, 2020 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Sec

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Number) December 17, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

December 21, 2020 EX-1.2

Placement Agency Agreement between Atossa Therapeutics, Inc. and Maxim Group LLC, dated December 17, 2020.

Exhibit 1.2 December 17, 2020 Mr. Steven C. Quay Chief Executive Officer Atossa Therapeutics, Inc. 107 Spring Street Seattle, WA 98104 Dear Mr. Quay: This letter (the “Agreement”) constitutes the agreement between Maxim Group LLC, a limited liability company formed under the laws of the State of New York (“Maxim” or the “Placement Agent”) and Atossa Therapeutics, Inc., a company incorporated under

December 21, 2020 EX-1.1

Securities Purchase Agreement dated December 17, 2020

Exhibit 1.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of December 17, 2020, between Atossa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condit

December 21, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 21, 2020 (December 17, 2020) ATOSSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of in

December 21, 2020 EX-4.1

Current Report on Form 8-K, as Exhibit 4.1

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

December 21, 2020 424B5

14,000,000 Shares of Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-248555 PROSPECTUS SUPPLEMENT (To Prospectus dated September 10, 2020) 14,000,000 Shares of Common Stock We are offering 14,000,000 shares (the “shares”) of our common stock, par value $0.18 per share (the “common stock”) pursuant to this prospectus supplement and the accompanying prospectus. In a concurrent private placement,

December 18, 2020 SC 13G

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. ____)* A

CUSIP No: 04962H506 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. )* Atossa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Numb

December 14, 2020 EX-3.1

Certificate of Designation of Preferences, Rights and Limitations of Series C Convertible Preferred Stock

Exhibit 3.1 ATOSSA THERAPEUTICS, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Steven C. Quay and Kyle Guse, do hereby certify that: 1. They are the President and Secretary, respectively, of Atossa Therapeutics, Inc., a Delaware corporation (the “Corpora

December 14, 2020 EX-1.1

Underwriting Agreement, dated as of December 8, 2020, between Atossa Therapeutics, Inc. and Maxim Group LLC

Exhibit 1.1 14,575,000 SHARES of Common Stock, 5,425 SHARES OF SERIES C CONVERTIBLE PREFERRED STOCK, AND 15,000,000 WARRANTS (EXERCISABLE for 15,000,000 shares OF COMMON STOCK) OF Atossa Therapeutics, Inc. UNDERWRITING AGREEMENT December 8, 2020 Maxim Group LLC As the Representative of the Several underwriters, if any, named in Schedule I hereto 405 Lexington Avenue, 2nd Floor New York, New York 1

December 14, 2020 8-K

Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 14, 2020 (December 8, 2020) ATOSSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of inc

December 14, 2020 EX-4.1

Form of Warrant

Exhibit 4.1 FORM OF COMMON STOCK PURCHASE WARRANT ATOSSA THERAPEUTICS, INC. Warrant Shares: [] Initial Exercise Date: [], 2020 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (th

December 11, 2020 424B3

Units Consisting of an Aggregate of 14,575,000 Shares of Common Stock 5,425 Shares of Series C Convertible Preferred Stock and Warrants Convertible Into Up to 15,000,000 Shares of Common Stock (and the Shares of Common Stock Underlying the Preferred

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-250820 Units Consisting of an Aggregate of 14,575,000 Shares of Common Stock 5,425 Shares of Series C Convertible Preferred Stock and Warrants Convertible Into Up to 15,000,000 Shares of Common Stock (and the Shares of Common Stock Underlying the Preferred Stock and Warrants) Units consisting of an aggregate of 14,57

December 8, 2020 EX-3.1

Form of Series C Convertible Preferred Stock

Exhibit 3.1 FORM OF ATOSSA THERAPEUTICS, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Steven C. Quay and Kyle Guse, do hereby certify that: 1. They are the President and Secretary, respectively, of Atossa Therapeutics, Inc., a Delaware corporation (the

December 8, 2020 8-K

Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 8, 2020 (December 8, 2020) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of inco

December 8, 2020 EX-4.2

Form of Warrant Agency Agreement

Exhibit 4.2 ATOSSA THERAPEUTICS, INC. and VSTOCK TRANSFER, LLC, as Warrant Agent Form of Warrant Agency Agreement Dated as of , 2020 FORM OF WARRANT AGENCY AGREEMENT WARRANT AGENCY AGREEMENT, dated as of , 2020 (“Agreement”), between Atossa Therapeutics, Inc., a corporation organized under the laws of the State of Delaware (the “Company”), and VStock Transfer, LLC., a limited lability company orga

December 8, 2020 EX-4.1

Form of Common Stock Purchase Warrant

Exhibit 4.1 FORM OF COMMON STOCK PURCHASE WARRANT ATOSSA THERAPEUTICS, INC. Warrant Shares: [] Initial Exercise Date: [], 2020 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (th

December 7, 2020 CORRESP

-

VIA EDGAR December 7, 2020 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

December 7, 2020 CORRESP

-

VIA EDGAR December 7, 2020 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

December 1, 2020 EX-4.9

Form of 2020 Warrant

Exhibit 4.9 FORM OF COMMON STOCK PURCHASE WARRANT ATOSSA THERAPEUTICS, INC. Warrant Shares: [] Initial Exercise Date: [], 2020 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (th

December 1, 2020 EX-3.8

Form of Certificate of Designations of Preference, Rights and Limitations of Series C Convertible Preferred Stock

Exhibit 3.8 FORM OF ATOSSA THERAPEUTICS, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Steven C. Quay and Kyle Guse, do hereby certify that: 1. They are the President and Secretary, respectively, of Atossa Therapeutics, Inc., a Delaware corporation (the

December 1, 2020 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 [ ] SHARES of Common Stock, [ ] SHARES OF SERIES C CONVERTIBLE PREFERRED STOCK, AND [ ] WARRANTS (EXERCISABLE for [ ] shares OF COMMON STOCK) OF Atossa Therapeutics, Inc. UNDERWRITING AGREEMENT December [ ], 2020 Maxim Group LLC As the Representative of the Several underwriters, if any, named in Schedule I hereto 405 Lexington Avenue, 2nd Floor New York, New York 10174 Ladies and Gentl

December 1, 2020 S-1/A

- FORM S-1/A

Table of Contents As filed with the Securities and Exchange Commission on December 1, 2020 Registration No.

December 1, 2020 EX-4.10

Form of 2020 Warrant Agency Agreement

Exhibit 4.10 ATOSSA THERAPEUTICS, INC. and VSTOCK TRANSFER, LLC, as Warrant Agent Form of Warrant Agency Agreement Dated as of , 2020 FORM OF WARRANT AGENCY AGREEMENT WARRANT AGENCY AGREEMENT, dated as of , 2020 (“Agreement”), between Atossa Therapeutics, Inc., a corporation organized under the laws of the State of Delaware (the “Company”), and VStock Transfer, LLC., a limited lability company org

November 30, 2020 8-K

- FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 26, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commis

November 20, 2020 S-1

Registration Statement - FORM S-1

Table of Contents As filed with the Securities and Exchange Commission on November 20, 2020 Registration No.

November 13, 2020 EX-99.1

Atossa Therapeutics Announces Third Quarter 2020 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Third Quarter 2020 Financial Results and Provides Corporate Update SEATTLE, November 13, 2020 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical need with a current focus on breast cancer and COVID-19, today annou

November 13, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commis

November 13, 2020 10-Q

Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

September 25, 2020 EX-1.1

Equity Distribution Agreement, dated as of September 25, 2020, by and between Atossa Therapeutics, Inc. and Maxim Group LLC

Exhibit 1.1 ATOSSA THERAPEUTICS, INC. $10,000,000 COMMON STOCK EQUITY DISTRIBUTION AGREEMENT September 25, 2020 Maxim Group LLC 405 Lexington Avenue New York, New York 10174 Ladies and Gentlemen: Atossa Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Maxim Group LLC, as follows: 1. Issuance and Sale of Shares. The Company agrees that, from

September 25, 2020 424B3

ATOSSA THERAPEUTICS, INC. Up to $10,000,000 Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-248555 PROSPECTUS SUPPLEMENT (To Prospectus dated September 10, 2020) ATOSSA THERAPEUTICS, INC. Up to $10,000,000 Common Stock We have entered into an Equity Distribution Agreement, dated September 25, 2020, or the Distribution Agreement, with Maxim Group LLC, or Maxim, relating to shares of our common stock, par value $0.18 per share, offered

September 25, 2020 8-K

Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 25, 2020 (September 25, 2020) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of

September 8, 2020 CORRESP

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September 8, 2020 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

September 2, 2020 S-3

Included in registrant’s Registration Statement on Form S-3 (File No. 333-248555) effective September 10, 2020

Table of Contents As filed with the Securities and Exchange Commission on September 2, 2020 Registration Statement No.

September 2, 2020 EX-4.1

Form of Senior Indenture

Exhibit 4.1 ATOSSA THERAPEUTICS, INC. Debt Securities Indenture Dated as of [ ] [ ]., as Trustee CROSS-REFERENCE TABLE This Cross-Reference Table is not a part of the Indenture TIA Section Indenture Section 310(a)(1) 7.10 (a)(2) 7.10 (a)(3) N.A. (a)(4) N.A. (b) 7.08; 7.10; 12.02 311(a) 7.11 (b) 7.11 (c) N.A. 312(a) 2.05 (b) 12.03 (c) 12.03 313(a) 7.06 (b)(1) N.A. (b)(2) 7.06 (c) 12.02 (d) 7.06 314

August 13, 2020 10-Q

Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

August 13, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 13, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissi

August 13, 2020 EX-99.1

Atossa Therapeutics Announces Second Quarter 2020 Financial Results and Provides Corporate Update

Exhibit 99.1 Atossa Therapeutics Announces Second Quarter 2020 Financial Results and Provides Corporate Update SEATTLE, August 13, 2020 (GLOBE NEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical need with a current focus on breast cancer and COVID-19, today announ

May 19, 2020 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 15, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

May 13, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 13, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

May 13, 2020 10-Q

Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA THERAPEUTICS, INC.

May 13, 2020 EX-4.1

Current Report on Form 10Q, as Exhibit 4.1

Exhibit 4.1 INCENTIVE STOCK OPTION AGREEMENT UNDER THE ATOSSA THERAPEUTICS, INC. 2020 STOCK INCENTIVE PLAN Name of Optionee: No. of Option Shares: Option Exercise Price per Share: $ [FMV on Grant Date (110% of FMV if a 10% owner)] Grant Date: Expiration Date: [up to 10 years (5 if a 10% owner)] Pursuant to the Atossa Therapeutics, Inc. 2020 Stock Incentive Plan as amended through the date hereof (

May 13, 2020 EX-99.1

Atossa Therapeutics Announces First Quarter 2020 Financial Results and Provides Company Update on COVID-19 HOPE and Endoxifen Programs

EX-99.1 2 ex182513.htm EXHIBIT 99.1 Exhibit 99.1 Atossa Therapeutics Announces First Quarter 2020 Financial Results and Provides Company Update on COVID-19 HOPE and Endoxifen Programs SEATTLE, May 13, 2020 (GLOBENEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical

April 13, 2020 EX-4.1

Current Report on Form 8-K, as Exhibit 4.1

Exhibit 4.1 STOCK OPTION AGREEMENT UNDER THE ATOSSA THERAPEUTICS, INC. 2020 STOCK INCENTIVE PLAN (Subject to Shareholder approval May 15, 2020) Name of Optionee: No. of Option Shares: Option Exercise Price per Share: $ Vesting Commencement Date: Grant Date: Expiration Date: Pursuant to the Atossa Therapeutics, Inc. 2020 Stock Incentive Plan (the “Plan”), Atossa Therapeutics, Inc. (the “Company”) h

April 13, 2020 DEF 14A

Atossa Therapeutics, Inc. 2020 Stock Incentive Plan

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☑ Definitive Proxy State

April 13, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 9, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

March 26, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 26, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissio

March 26, 2020 EX-22.1

Current Report on Form 10K, as exhibit 22.1

EX-22.1 3 ex167063.htm EXHIBIT 22.1 Exhibit 22.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

March 26, 2020 EX-4.16

Description of Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

Exhibit 4.16 DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of the date of the Annual Report on Form 10-K of which this exhibit is a part, Atossa Therapeutics, Inc. (the “Company” or “we” or “our”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): c

March 26, 2020 EX-99.1

Atossa Therapeutics Announces Fourth Quarter and Year End 2019 Financial Results and Provides Company Update

Exhibit 99.1 Atossa Therapeutics Announces Fourth Quarter and Year End 2019 Financial Results and Provides Company Update SEATTLE, March 26, 2020 (GLOBENEWSWIRE) - Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods to treat breast cancer and other breast conditions, today announced financial results for the fourth

March 26, 2020 10-K

ATOS / Atossa Genetics Inc 10-K - Annual Report - FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ☒ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2019 OR ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number 001-35

February 10, 2020 8-K

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): February 7, 2020 (February 7, 2020) Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of inco

February 10, 2020 EX-1.1

Equity Distribution Agreement, dated as of February 7, 2020, by and between Atossa Therapeutics, Inc. and Oppenheimer & Co. Inc.

Exhibit 1.1 ATOSSA THERAPEUTICS, INC. $5,000,000 COMMON STOCK EQUITY DISTRIBUTION AGREEMENT February 7, 2020 Oppenheimer & Co. Inc. 85 Broad Street, 26th Floor New York, New York 10004 Ladies and Gentlemen: Atossa Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Oppenheimer & Co. Inc., as follows: 1. Issuance and Sale of Shares. The Company

February 7, 2020 424B3

ATOSSA THERAPEUTICS, INC. Up to $5,000,000 Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-220572 PROSPECTUS SUPPLEMENT (To Prospectus dated October 5, 2017) ATOSSA THERAPEUTICS, INC. Up to $5,000,000 Common Stock We have entered into an Equity Distribution Agreement, dated February 7, 2020, or the Distribution Agreement, with Oppenheimer & Co. Inc., or Oppenheimer, relating to shares of our common stock, par value $0.18 per share, o

January 7, 2020 EX-3.1

Amended and Restated Certificate of Incorporation of Atossa Therapeutics, Inc.

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ATOSSA GENETICS INC. Atossa Genetics Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), hereby certifies as follows: FIRST: That the Board of Directors of the Corporation has duly adopted resolutions authorizing the Corporation to execute and file wi

January 7, 2020 EX-3.2

Amendment to Bylaws of Atossa Therapeutics, Inc.

Exhibit 3.2 AMENDED AND RESTATED BY-LAWS OF ATOSSA THERAPEUTICS, INC. (the “Corporation”) ARTICLE I Stockholders SECTION 1. Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these By-laws as an “Annual Meeting”) shall be held at the hour, date and place within or without the United States which is fixed by the Board of Directors, which time, date and place m

January 7, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 6, 2020 Atossa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commissi

November 13, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

November 13, 2019 EX-99.1

Atossa Genetics Announces Third Quarter 2019 Financial Results and Provides Company Update Completes Third Quarter with Cash and Cash Equivalents of $15.3 Million

Exhibit 99.1 Atossa Genetics Announces Third Quarter 2019 Financial Results and Provides Company Update Completes Third Quarter with Cash and Cash Equivalents of $15.3 Million SEATTLE, November 13, 2019 (GLOBENEWSWIRE) - Atossa Genetics Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods to treat breast cancer and other breast conditio

November 13, 2019 10-Q

ATOS / Atossa Genetics Inc 10-Q - Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA GENETICS INC.

October 15, 2019 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 14, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission F

August 13, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 13, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission Fi

August 13, 2019 EX-99.1

Atossa Genetics Announces Second Quarter 2019 Financial Results and Provides Company Update Completes Second Quarter with Cash and Cash Equivalents of $17.1 Million

Exhibit 99.1 Atossa Genetics Announces Second Quarter 2019 Financial Results and Provides Company Update Completes Second Quarter with Cash and Cash Equivalents of $17.1 Million SEATTLE, August 13, 2019 (GLOBENEWSWIRE) - Atossa Genetics Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods to treat breast cancer and other breast conditio

August 13, 2019 10-Q

ATOS / Atossa Genetics Inc 10-Q - Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA GENETICS INC.

June 27, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 27, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission File

June 27, 2019 EX-99.1

Atossa Genetics’ Preliminary Phase 2 Study Achieves Primary Endpoint: Topical Endoxifen Rapidly Reduces Breast Density

Exhibit 99.1 Atossa Genetics’ Preliminary Phase 2 Study Achieves Primary Endpoint: Topical Endoxifen Rapidly Reduces Breast Density SEATTLE, WA - (Marketwired) – June 27, 2019 - Atossa Genetics Inc. (Nasdaq:ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods for breast cancer and other breast conditions, today announced that a preliminary analysis f

May 17, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 16, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission File

May 13, 2019 EX-99.1

Atossa Genetics Announces First Quarter 2019 Financial Results and Provides Company Update Completes First Quarter with Cash and Cash Equivalents of $19.6 Million

Exhibit 99.1 Atossa Genetics Announces First Quarter 2019 Financial Results and Provides Company Update Completes First Quarter with Cash and Cash Equivalents of $19.6 Million SEATTLE, May 13, 2019 (GLOBENEWSWIRE) - Atossa Genetics Inc. (Nasdaq:ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods to treat breast cancer and other breast conditions, to

May 13, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 13, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission File

May 13, 2019 10-Q

ATOS / Atossa Genetics Inc 10-Q Quarterly Report FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA GENETICS INC.

April 12, 2019 DEF 14A

ATOS / Atossa Genetics Inc FORM DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☑ Definitive Proxy State

March 28, 2019 EX-99.1

Atossa Genetics Announces Year End 2018 Financial Results and Provides Company Update

Exhibit 99.1 Atossa Genetics Announces Year End 2018 Financial Results and Provides Company Update SEATTLE, March 28, 2019 (GLOBENEWSWIRE) - Atossa Genetics Inc. (Nasdaq:ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods to treat breast cancer and other breast conditions, today announced year end 2018 financial results and provided an update on rec

March 28, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 28, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission Fil

March 28, 2019 EX-22.1

List of Subsidiaries

Exhibit 22.1 LIST OF SUBSIDIARIES Atossa Genetics UK Ltd. Atossa Genetics AUS Pty Ltd.

March 28, 2019 10-K

ATOS / Atossa Genetics Inc FORM 10-K (Annual Report)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark one) ☒ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2018 OR ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from: to Commission File Number 001-35

February 8, 2019 SC 13G/A

ATOS / Atossa Genetics Inc / INTRACOASTAL CAPITAL, LLC - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Atossa Genetics Inc. (Name of Issuer) Common Stock, $0.18 par value per share (Title of Class of Securities) 04962H506 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rul

January 15, 2019 EX-4.1

Current Report on Form 8-K, as Exhibit 4.1

Exhibit 4.1 STOCK OPTION AGREEMENT UNDER THE ATOSSA GENETICS INC. 2010 STOCK OPTION AND INCENTIVE PLAN (as amended January 13, 2019) Name of Optionee: No. of Option Shares: Option Exercise Price per Share: Vesting Commencement Date: Grant Date: Expiration Date: Pursuant to the Atossa Genetics Inc. 2010 Stock Option and Incentive Plan as amended through the date hereof (the “Plan”), Atossa Genetics

January 15, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

8-K 1 atos201901158k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 13, 2019 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdicti

January 15, 2019 EX-4.2

2010 Stock Option and Incentive Plan, as amended January 13, 2019

Exhibit 4.2 ATOSSA GENETICS INC. 2010 STOCK OPTION AND INCENTIVE PLAN (as amended by the Board of Directors on January 13, 2019 (the “2019 Amendment”) subject to and conditioned upon stockholder approval) SECTION 1. GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the Atossa Genetics Inc. 2010 Stock Option and Incentive Plan (the “Plan”). The purpose of the Plan is to encourage and

November 14, 2018 10-Q

ATOS / Atossa Genetics Inc FORM 10-Q (Quarterly Report)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2018 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35610 ATOSSA GENETICS INC.

November 13, 2018 8-K

Financial Statements and Exhibits, Non-Reliance on Previously Issued Financial Statements or a Related Audit Report or Completed Interim Review, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 12, 2018 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

November 13, 2018 EX-99.1

Atossa Genetics Announces Third Quarter 2018 Financial Results And Provides Company Update

Exhibit 99.1 Atossa Genetics Announces Third Quarter 2018 Financial Results And Provides Company Update SEATTLE, November 13, 2018 - Atossa Genetics Inc. (NASDAQ: ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods to treat breast cancer and other breast conditions, today announced third quarter ended September 30, 2018 financial results and provide

November 13, 2018 10-Q/A

ATOS / Atossa Genetics Inc FORM 10-Q/A (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q/A (Amendment No.

September 13, 2018 EX-99.2

Preliminary Topical Endoxifen Male Phase 1 Results All Objectives Successfully Met September 13, 2018 1 107 Spring St. Seattle WA 98104

Exhibit 99.2 Preliminary Topical Endoxifen Male Phase 1 Results All Objectives Successfully Met September 13, 2018 1 107 Spring St. Seattle WA 98104 Forward - Looking Statements Some of the information presented herein may contain projections or other forward - looking statements regarding future events or the future financial performance of the Company which the Company undertakes no obligation t

September 13, 2018 8-K

Financial Statements and Exhibits, Other Events, Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 13, 2018 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission

September 13, 2018 EX-99.1

Atossa Genetics Announces Preliminary Results from Male Phase 1 Study of Topical Endoxifen ***All Objectives Successfully Met*** Conference Call to Be Held Today at 10 am Eastern Time

Exhibit 99.1 Atossa Genetics Announces Preliminary Results from Male Phase 1 Study of Topical Endoxifen ***All Objectives Successfully Met*** Conference Call to Be Held Today at 10 am Eastern Time SEATTLE, Sept. 13, 2018 (GLOBE NEWSWIRE) - Atossa Genetics Inc. (NASDAQ:ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics and delivery methods for breast cancer and other br

August 13, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 13, 2018 Atossa Genetics Inc. (Exact name of registrant as specified in its charter) Delaware 001-35610 26-4753208 (State or other jurisdiction of incorporation) (Commission Fi

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