CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock)
US ˙ NasdaqGM ˙ US2075231017

Mga Batayang Estadistika
CIK 1835268
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock)
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 13, 2025 EX-10.1

Non-Employee Director Compensation Program

Exhibit 10.1 CONNECT BIOPHARMA HOLDINGS LIMITED NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM (As Amended Effective June 24, 2025) Eligible Directors (as defined below) on the Board of Directors (the “Board”) of Connect Biopharma Holdings Limited (the “Company”) shall be eligible to receive cash and equity compensation for their service on the Board as set forth in this Non-Employee Director Compensa

August 13, 2025 EX-99.1

Connect Biopharma Reports Second Quarter 2025 Financial Results and Provides Business Update – Initiated Phase 2 Seabreeze STAT asthma and COPD studies evaluating rademikibart as an adjunct treatment for acute exacerbations – – Presented positive dat

Exhibit 99.1 Connect Biopharma Reports Second Quarter 2025 Financial Results and Provides Business Update – Initiated Phase 2 Seabreeze STAT asthma and COPD studies evaluating rademikibart as an adjunct treatment for acute exacerbations – – Presented positive data at ATS 2025 and EAACI 2025 supporting the potential of rademikibart to deliver differentiated efficacy and safety in patients with eosi

August 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2025 Connect Biopharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incor

August 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40212 Con

July 22, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 22, 2025 Connect Biopharma H

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 22, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpo

July 21, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2025 Connect Biopharma H

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpo

July 18, 2025 F-6 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM F-6 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FOR AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS Connec

As filed with the Securities and Exchange Commission on July 18, 2025 Registration No.

July 18, 2025 EX-99.1

AMENDMENT TO THE DEPOSIT AGREEMENT

AMENDMENT TO THE DEPOSIT AGREEMENT THIS AMENDMENT dated as of July 18, 2025 (hereafter, the “Amendment”) is amending the Deposit Agreement, dated as of March 18, 2021 (the “Deposit Agreement”), by and among (i) Connect Biopharma Holdings Limited, a company incorporated in the Cayman Islands (together with its successors, the “Company”), (ii) Deutsche Bank Trust Company Americas, an indirect wholly owned subsidiary of Deutsche Bank A.

July 17, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpo

July 9, 2025 EX-99.1

Connect Biopharma’s Exclusive Licensee in China, Simcere Pharmaceutical, Announced Submission of its New Drug Application for Rademikibart for the Treatment of Atopic Dermatitis in China

Exhibit 99.1 Connect Biopharma’s Exclusive Licensee in China, Simcere Pharmaceutical, Announced Submission of its New Drug Application for Rademikibart for the Treatment of Atopic Dermatitis in China SAN DIEGO July 9, 2025, (GLOBE NEWSWIRE) - Connect Biopharma Holdings Limited (Nasdaq: CNTB) (“Connect Biopharma”, “Connect”, or the “Company”), a clinical-stage biopharmaceutical company focused on t

July 9, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 9, 2025 Connect Biopharma Ho

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 9, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpor

June 24, 2025 CORRESP

Connect Biopharma Holdings Limited 3580 Carmel Mountain Road, Suite 200 San Diego, CA 92130

CORRESP Connect Biopharma Holdings Limited 3580 Carmel Mountain Road, Suite 200 San Diego, CA 92130 June 24, 2025 VIA EDGAR Alan Campbell Office of Life Sciences Division of Corporation Finance U.

June 10, 2025 S-8

As filed with the Securities and Exchange Commission on June 10, 2025

S-8 As filed with the Securities and Exchange Commission on June 10, 2025 Registration No.

June 10, 2025 EX-10.1

Amendment to Sales Agreement, dated June 10, 2025, between Connect Biopharma Holdings Limited and Leerink Partners LLC.

Exhibit 10.1 June 9, 2025 Connect Biopharm LLC 3580 Carmel Mountain Road, Suite 200 San Diego, California 92130 Cantor Fitzgerald & Co. 110 East 59th Street, 6th floor New York, New York 10022, Attention: General Counsel Email: [email protected] with copies to: Latham & Watkins LLP 12670 High Bluff Drive San Diego, California 92130 Attention: Michael E. Sullivan Email: [email protected] D

June 10, 2025 F-3

As filed with the Securities and Exchange Commission on June 10, 2025

Table of Contents As filed with the Securities and Exchange Commission on June 10, 2025 Registration No.

June 10, 2025 EX-FILING FEES

Calculation of Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-8 (Form Type) Connect Biopharma Holdings Limited (Exact name of registrant as specified in its charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (2) Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Ordinary shares, par value US $0.

June 10, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 CALCULATION OF FILING FEE TABLE Registration Statement on Form F-3 (Form Type) Connect Biopharma Holdings Limited (Exact Name of Registrant as Specified in its Charter) Table 1 – Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees To Be Paid Equity Ordinary shares, $0.

June 10, 2025 EX-4.4

Form of Indenture.

Exhibit 4.4 CONNECT BIOPHARMA HOLDINGS LIMITED INDENTURE Dated as of , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 4 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1. Issuable in Series 5 Section 2.2

June 10, 2025 EX-10.2

2024 Employment Inducement Incentive Award Plan

Exhibit 10.2 CONNECT BIOPHARMA HOLDINGS LIMITED 2024 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN 1. Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel, to provide additional incentives to Eligible Persons and to promote the success of the Company’s business. 2. Definitions. The following definitions shall apply as used herein and in the individual

May 15, 2025 EX-99.1

Connect Biopharma Reports First Quarter 2025 Financial Results and Provides Business Update Initiated Phase 2 Seabreeze STAT Asthma and Seabreeze STAT COPD studies evaluating rademikibart as an adjunct treatment for acute exacerbations in Asthma and

Exhibit 99.1 Connect Biopharma Reports First Quarter 2025 Financial Results and Provides Business Update Initiated Phase 2 Seabreeze STAT Asthma and Seabreeze STAT COPD studies evaluating rademikibart as an adjunct treatment for acute exacerbations in Asthma and COPD in May 2025; topline data expected in 1H 2026 Published positive data from its global Phase 2 study supporting potential of rademiki

May 15, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40212 Co

May 15, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpor

May 14, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpor

May 14, 2025 EX-99.1

Connect Biopharma Initiates Phase 2 Seabreeze STAT COPD Study Evaluating Rademikibart for the Treatment of Acute Exacerbations in COPD – Expect to report topline data from the Seabreeze STAT COPD study in 1H 2026 –

Exhibit 99.1 Connect Biopharma Initiates Phase 2 Seabreeze STAT COPD Study Evaluating Rademikibart for the Treatment of Acute Exacerbations in COPD – Expect to report topline data from the Seabreeze STAT COPD study in 1H 2026 – SAN DIEGO May 14, 2025, (GLOBE NEWSWIRE) - Connect Biopharma Holdings Limited (Nasdaq: CNTB) (Connect Biopharma, Connect or the Company), a clinical-stage biopharmaceutical

May 13, 2025 EX-99.1

Connect Biopharma Initiates Phase 2 Seabreeze STAT Asthma Study Evaluating Rademikibart for the Treatment of Acute Exacerbations in Asthma – Expect to report topline data from the Seabreeze STAT Asthma study in 1H 2026 – – On track to initiate simila

Exhibit 99.1 Connect Biopharma Initiates Phase 2 Seabreeze STAT Asthma Study Evaluating Rademikibart for the Treatment of Acute Exacerbations in Asthma – Expect to report topline data from the Seabreeze STAT Asthma study in 1H 2026 – – On track to initiate similarly-designed Phase 2 study in patients with COPD imminently – SAN DIEGO May 13, 2025, (GLOBE NEWSWIRE) - Connect Biopharma Holdings Limit

May 13, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpor

April 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Connect Biopharma H

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorpo

April 1, 2025 EX-99.1

Connect Biopharma Announces Positive Type C Meeting with the FDA for Rademikibart – FDA aligned on plan to initiate parallel Phase 2 trials of rademikibart in patients with moderate-to-severe asthma or COPD experiencing an acute exacerbation – – Expe

Exhibit 99.1 Connect Biopharma Announces Positive Type C Meeting with the FDA for Rademikibart – FDA aligned on plan to initiate parallel Phase 2 trials of rademikibart in patients with moderate-to-severe asthma or COPD experiencing an acute exacerbation – – Expect to initiate both trials in Q2 2025 – SAN DIEGO April 1, 2025, (GLOBE NEWSWIRE) - Connect Biopharma Holdings Limited (Nasdaq: CNTB) (Co

March 31, 2025 EX-10.18

Lease, effective as of October 25, 2024, by and between Connect Biopharm LLC and Gateway Torrey Hills LLC

Exhibit 10.18 LEASE BETWEEN GATEWAY TORREY HILLS LLC AND CONNECT BIOPHARM LLC LEASE (Short Form) THIS LEASE is made as of October 25, 2024, by and between GATEWAY TORREY HILLS LLC, a Delaware limited liability company, hereafter called “Landlord,” and CONNECT BIOPHARM LLC, a California limited liability company hereafter called “Tenant.” ARTICLE 1. BASIC LEASE PROVISIONS Each reference in this Lea

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) þ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-40

March 31, 2025 EX-10.16

Addendum to Employment Offer Letter for Severance Benefits, dated August 7, 2024, between Connect Biopharm LLC and Lisa Peraza

Exhibit 10.16 Addendum To Employment Offer Letter For Severance Benefits The provisions of this Addendum to Employment Offer Letter for Severance Benefits (the “Addendum”) are incorporated into, and are made a part of, the employment offer letter (the “Offer Letter”) by and between you, Lisa Peraza, and Connect Biopharm LLC (“Company”), to which this Addendum is attached. Capitalized terms used in

March 31, 2025 EX-10.15

Employment Offer Letter, dated August 7, 2024, between Connect Biopharm LLC and Lisa Peraza

Exhibit 10.15 August 7, 2024 Lisa Peraza Via Electronic Mail Re: Employment Terms Dear Lisa: Connect Biopharm LLC (the “Company” or “Connect”) is pleased to offer you the position of Vice President, Finance. As applicable, references to Company or Connect also include its affiliated entities. This position reports directly into David Szekeres, the Company’s President. You are expected to be presen

March 31, 2025 EX-10.17

First Amendment to Lease, effective as of October 25, 2024, by and between Connect Biopharm LLC and Paseo Del Mar LLC

Exhibit 10.17 FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT (the “Amendment”) is made and entered into as of October 25, 2024, by and between PASEO DEL MAR LLC, a Delaware limited liability company, hereafter called “Landlord,” and CONNECT BIOPHARM LLC, a California limited liability company, hereafter called “Tenant.” RECITALS A.Landlord and Tenant are parties to that certain lease dated December

March 31, 2025 EX-21.1

Subsidiaries of the Registrant

Exhibit 21.1 Subsidiaries of Connect Biopharma Holdings Limited Name of Subsidiary State or Other Jurisdiction of Incorporation or Organization Connect Biopharma HongKong Limited Hong Kong Connect Biopharm LLC California Connect Biopharma Australia PTY LTD Australia Suzhou Connect Biopharma Co., Ltd. People’s Republic of China Connect Biopharma (Beijing) Co., Ltd. People’s Republic of China Connec

March 31, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2025 Connect Biopharma Holdings Limited (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40212 Not Applicable (State or Other Jurisdiction of Incorp

March 31, 2025 EX-99.1

Connect Biopharma Reports 2024 Full-Year Financial Results and Provides Business Update Strengthened leadership team with key appointments, including Barry Quart, Pharm.D. as CEO, and David Szekeres as President, bringing deep clinical, regulatory, o

Exhibit 99.1 Connect Biopharma Reports 2024 Full-Year Financial Results and Provides Business Update Strengthened leadership team with key appointments, including Barry Quart, Pharm.D. as CEO, and David Szekeres as President, bringing deep clinical, regulatory, operational and strategic expertise Unveiled rapid clinical development program for rademikibart initially targeting acute care in asthma

March 31, 2025 EX-19.1

Insider Trading Compliance Policy

Exhibit 19.1 Connect Biopharma Holdings Limited Insider Trading Compliance Policy Contents Page I.Summary 1 II.Statement of Policies Prohibiting Insider Trading 2 III.Explanation of Insider Trading 3 IV.Statement of Procedures to Prevent Insider Trading 7 V.Additional Prohibited Transactions 10 VI.Rule 10b5-1 Trading Plans and Rule 144 12 VII.Execution and Return of Certification of Compliance 14

March 28, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025. Commission File Number: 001-402

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025. Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) 3580 Carmel Mountain Road, Suite 200 San Diego, California 92130

March 28, 2025 EX-99.1

Connect Biopharma Announces Receipt of Nasdaq Deficiency Notice Regarding Minimum Bid Price Requirement

Exhibit 99.1 Connect Biopharma Announces Receipt of Nasdaq Deficiency Notice Regarding Minimum Bid Price Requirement SAN DIEGO March 28, 2025, (GLOBE NEWSWIRE) - Connect Biopharma Holdings Limited (Nasdaq: CNTB) (Connect Biopharma or the Company), a clinical-stage biopharmaceutical company focused on transforming acute and chronic care in asthma and chronic obstructive pulmonary disease (COPD), to

December 23, 2024 EX-16.1

Letter of PwC China

Exhibit 16.1 December 23, 2024 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read the statements made by Connect Biopharma Holdings Limited (copy attached), which we understand will be filed with the Securities and Exchange Commission, pursuant to Form 6-K of Connect Biopharma Holdings Limited dated for the month of December 2024. We agree with t

December 23, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2024. Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2024. Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) 12265 El Camino Real, Suite 350 San Diego, California 92130,

September 6, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2024 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2024 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Add

September 5, 2024 EX-99.1

Connect Biopharma Holdings Ltd. Condensed Consolidated Income Statement Data

EXHIBIT 99.1 Connect Biopharma Reports First Half 2024 Financial Results and Provides Business Update •Announced new U.S.-based leadership with the appointment of Barry Quart, Pharm.D. as Chief Executive Officer (CEO) and David Szekeres as President •Connect’s new management is currently evaluating the future clinical development strategy for rademikibart •As part of Connect’s transformation into

September 5, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2024 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2024 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Add

August 2, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2024 Commission File Number: 001-402

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2024 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Addres

July 1, 2024 SC 13D/A

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / Panacea Innovation Ltd - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary Shares (Title of Class of Securities) 207523101** (CUSIP Number) James Huang Panacea Venture No. 5, Lane 1350, Fuxing Middle Road Xuhui District, Shanghai China 200031 (86-21) 6176-110

June 12, 2024 EX-10.2

Employment Agreement between Connect Biopharm LLC and its affiliates and Barry Quart

EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is entered into by and between Connect Biopharm LLC (the “Company”) and its affiliates (the “Company Group”), and Barry Quart (“Executive”), and shall be effective as of June 12, 2024 (the “Effective Date”).

June 12, 2024 EX-10.3

between Connect Biopharm LLC and its affiliates and

EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is entered into by and between Connect Biopharm LLC (the “Company”) and its affiliates (the “Company Group”), and David Szekeres (“Executive”), and shall be effective as of June 12, 2024 (the “Effective Date”).

June 12, 2024 EX-10.1

Connect Biopharma Holdings Limited 2024 Employment Inducement Incentive Award Plan and Form of Stock Option Agreement thereunder

CONNECT BIOPHARMA HOLDINGS LIMITED 2024 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN 1.

June 12, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2024 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2024 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Address

April 16, 2024 EX-97

Connect Biopharma Holdings Limited

CONNECT BIOPHARMA HOLDINGS LIMITED POLICY FOR RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION Connect Biopharma Holdings Limited (the “Company”) has adopted this Policy for Recovery of Erroneously Awarded Compensation (the “Policy”), effective as of October 2, 20231 (the “Effective Date”).

April 16, 2024 EX-12.1

Principal Executive Officer Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 12.1 CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Zheng Wei, certify that: 1.I have reviewed this annual report on Form 20-F of Connect Biopharma Holdings Limited (the "Company"); 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the st

April 16, 2024 EX-99.1

Connect Biopharma Reports Full Year 2023 Financial Results and Provides Business Update

Connect Biopharma Reports Full Year 2023 Financial Results and Provides Business Update •Reported two positive readouts for rademikibart, the Company’s lead asset, from the Global Phase 2b trial in moderate-to-severe persistent asthma and from the China pivotal trial in moderate-to-severe atopic dermatitis (AD) •Type C meeting in AD and End-of-Phase 2 (EoP2) meeting in asthma have been scheduled with the U.

April 16, 2024 EX-4.5

Non-Employee Director Compensation Program

Non-Employee Director Compensation Program CONNECT BIOPHARMA HOLDINGS LIMITED NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM Eligible Directors (as defined below) on the board of directors (the “Board”) of Connect Biopharma Holdings Limited (the “Company”) shall be eligible to receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”).

April 16, 2024 EX-13.1

Principal Executive Officer Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 13.1 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the annual report of Connect Biopharma Holdings Limited (the “Company”) on Form 20-F for the year ended December 31, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Zheng Wei, Chief Executive Officer

April 16, 2024 EX-12.2

Principal Financial Officer Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 12.2 CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Steven Chan, certify that: 1.I have reviewed this annual report on Form 20-F of Connect Biopharma Holdings Limited (the "Company"); 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the

April 16, 2024 EX-15.1

Consent of PricewaterhouseCoopers Zhong Tian LLP, an independent registered public accounting firm.

Exhibit 15.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-266006, No. 333-254524) and Form F-3 (No. 333-264340) of Connect Biopharma Holdings Limited of our report dated April 16, 2024 relating to the financial statements, which appears in this Form 20-F. /s/ PricewaterhouseCoopers Z

April 16, 2024 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F o REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR o TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE SECURIT

April 16, 2024 EX-13.2

Principal Financial Officer Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 13.2 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the annual report of Connect Biopharma Holdings Limited (the “Company”) on Form 20-F for the year ended December 31, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Steven Chan, Chief Financial Office

April 16, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2024 Commission File Number: 001-4021

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2024 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address of p

February 27, 2024 SC 13D/A

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm247414d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston,

February 27, 2024 SC 13D/A

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / Panacea Innovation Ltd - SC 13D/A Activist Investment

SC 13D/A 1 d785358dsc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary Shares (Title of Class of Securities) 207523101** (CUSIP Number) James Huang Panacea Venture No. 5, Lane 1350, Fuxing Middle Road Xuhui District, Shanghai

February 13, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d785507dex991.htm EX-99.1 Exhibit 1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13D. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of t

February 13, 2024 EX-99

JOINT FILING AGREEMENT

EX-99 2 biofortune13ga20231231-fin.htm EX-99 Exhibit 99 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and acc

February 13, 2024 SC 13G/A

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / BioFortune Inc - SC 13G/A Passive Investment

Securities and Exchange Commission Washington, D.C. 20549 —————————————— Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* —————————————— Connect Biopharma Holdings Limited (Name of Issuer) Ordinary shares, par value $0.0

February 13, 2024 SC 13G/A

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / Wei Zheng - SC 13G/A Passive Investment

SC 13G/A 1 zhengwei13ga20231231-final.htm SC 13G/A Securities and Exchange Commission Washington, D.C. 20549 —————————————— Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* —————————————— Connect Biopharma Holdings Limit

February 13, 2024 SC 13D

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / Panacea Innovation Ltd - SC 13D Activist Investment

SC 13D 1 d785507dsc13d.htm SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary Shares (Title of Class of Securities) 207523101** (CUSIP Number) James Huang Panacea Venture No. 5, Lane 1350, Fuxing Middle Road Xuhui District, Shanghai China

February 12, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2024 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Addr

December 20, 2023 SC 13D/A

CNTB / Connect Biopharma Holdings Limited - Depositary Receipt (Common Stock) / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone

December 14, 2023 SC 13D/A

CNTB / Connect Biopharma Holdings Ltd - ADR / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2332921d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston,

December 12, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Addr

December 12, 2023 EX-99.1

Full Analysis Set (primary endpoint)

Connect Biopharma Announces Positive Rademikibart Global Phase 2b Topline Results in Adult Patients with Moderate-to-Severe Persistent Asthma • The global trial met its primary endpoint showing both doses of rademikibart treatment significantly improved lung function at Week 12 • The significant improvement in lung function was observed as early as Week 1 and was sustained through Week 24 with both doses of rademikibart • Significant improvement in asthma control occurred early and was sustained through Week 24 for both doses of rademikibart • Safety results suggest rademikibart was generally well tolerated • A conference call and webcast presentation to discuss the data will be held today at 8:30 a.

December 4, 2023 SC 13D/A

CNTB / Connect Biopharma Holdings Ltd - ADR / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone

November 21, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Addr

November 21, 2023 EX-99.1

EXCLUSIVE LICENSE AND COLLABORATION AGREEMENT by and between Connect Biopharma HongKong Limited Simcere Pharmaceutical Co., Ltd. Table of Contents

Exhibit 99.1 EXCLUSIVE LICENSE AND COLLABORATION AGREEMENT by and between Connect Biopharma HongKong Limited and Simcere Pharmaceutical Co., Ltd. Table of Contents 1. DEFINITIONS 3 2. LICENSE 12 3. GOVERNANCE 15 4. DEVELOPMENT AND REGULATORY MATTERS 18 5. COMMERCIALIZATION 23 6. MANUFACTURE AND SUPPLY 25 7. PAYMENTS 26 8. COMPLIANCE WITH LAWS 30 9. INTELLECTUAL PROPERTY 32 10. CONFIDENTIALITY 37 1

November 21, 2023 EX-99.2

Rademikibart Week 52 Results In patients that achieved IGA 0/1 or EASI-75 at Week 16

Exhibit 99.2 Connect Biopharma Announces Positive Long-Term Data from the China Pivotal Trial of Rademikibart in Patients with Moderate-to-Severe Atopic Dermatitis • Clinical response (IGA 0/1 and EASI-75) achieved at Week 16 with rademikibart treatment was maintained through Week 52 with both every two weeks (Q2W) and every four weeks (Q4W) dosing regimens o Approximately 90% of patients on Q4W d

November 1, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address o

October 20, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Addre

October 4, 2023 SC 13G/A

CNTB / Connect Biopharma Holdings Ltd - ADR / Huang James - SC 13G/A Passive Investment

SC 13G/A Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary Shares (Title of Class of Securities) 20752

October 4, 2023 EX-99

JOINT FILING AGREEMENT

EX-99 Exhibit 99 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G.

September 12, 2023 EX-99.1

Connect Biopharma Holdings Ltd.

EXHIBIT 99.1 Connect Biopharma Reports First Half 2023 Financial Results and Provides Business Update • Key data readouts with Company’s lead drug candidate rademikibart expected in the fourth quarter of 2023 o Topline results from Stage 2 of the China pivotal trial in atopic dermatitis o Topline results from Global Phase 2 trial in asthma • Cash balance of $131.6 million expected to support plann

September 12, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2023 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Add

September 12, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Add

July 24, 2023 CORRESP

*********

12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Austin Milan Beijing Munich Boston New York Brussels Orange County Century City Paris July 24, 2023 Chicago Riyadh Dubai San Diego Düsseldorf San Francisco Frankfurt Seoul Hamburg Shanghai Hong Kong Silicon Valley VIA EDGAR Houston Singapore London Tel Aviv Los Angeles T

July 14, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Address

June 23, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Address

June 23, 2023 EX-99.1

House Lease Contract

Exhibit 99.1 House Lease Contract Lessor: Taicang Science and Technology Venture Park Co., Ltd. (hereinafter referred to as “Party A”) Lessee: Suzhou Connect Biopharmaceuticals, Ltd. (hereinafter referred to as “Party B”) In accordance with the Civil Code of the People’s Republic of China and other relevant provisions, Party A and Party B (individually a “Party” and collectively the “Parties”) hav

June 5, 2023 EX-99.1

Corporate Presentation June 2023 | NASDAQ: CNTB Developing next-generation therapeutics for T cell-driven inflammatory diseases

Corporate Presentation June 2023 | NASDAQ: CNTB Developing next-generation therapeutics for T cell-driven inflammatory diseases Forward-looking statements This presentation regarding Connect Biopharma Holdings Limited ("Connect," "we," "us" or "our") has been prepared solely for informational purposes.

June 5, 2023 6-K

UNITED STATES

6-K 1 cntb6k20230605.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San D

June 1, 2023 EX-99.1

Connect Biopharma Announces Positive Long-Term Data from the Maintenance Period Through

Exhibit 99.1 Connect Biopharma Announces Positive Long-Term Data from the Maintenance Period Through Week 48 of CN002 Phase 2 Icanbelimod Trial in Patients with Moderate-to-Severe Ulcerative Colitis • Icanbelimod demonstrated sustained clinical remission, a regulatory relevant efficacy endpoint, through Week 48 in 80% of patients who achieved clinical remission at Week 12 of the induction period.

June 1, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Address

April 11, 2023 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE SECURITIES EXCHANGE ACT O

April 11, 2023 EX-15

Consent of PricewaterhouseCoopers Zhong Tian LLP, an independent registered public accounting firm.

Exhibit 15.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-266006, No. 333-254524) and Form F-3 (No. 333-264340) of Connect Biopharma Holdings Limited of our report dated April 11, 2023 relating to the financial statements, which appears in this Form 20-F. /s/ PricewaterhouseCoopers Z

April 11, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130, USA (Address

April 11, 2023 EX-12

Principal Financial Officer Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 12.2 CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Steven Chan, certify that: 1. I have reviewed this annual report on Form 20-F of Connect Biopharma Holdings Limited (the "Company"); 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make th

April 11, 2023 EX-99

Connect Biopharma Reports Full Year 2022 Financial Results and Provides Business Update CDE’s Pre-NDA Feedback Confirms CBP-201 for Atopic Dermatitis on Track for NDA Submission in China by End of First Quarter 2024

Connect Biopharma Reports Full Year 2022 Financial Results and Provides Business Update CDE’s Pre-NDA Feedback Confirms CBP-201 for Atopic Dermatitis on Track for NDA Submission in China by End of First Quarter 2024 SAN DIEGO and TAICANG, SUZHOU, China – April 11, 2023 – Connect Biopharma Holdings Limited (Nasdaq: CNTB) (Connect Biopharma or the Company), a global clinical-stage biopharmaceutical company developing T cell-driven therapies to treat inflammatory diseases, today announced financial results for the year ended December 31, 2022 and recent corporate highlights.

April 11, 2023 EX-13

Principal Executive Officer Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 13.1 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the annual report of Connect Biopharma Holdings Limited (the “Company”) on Form 20-F for the year ended December 31, 2022, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Zheng Wei, Chief Executive Officer

April 11, 2023 EX-12

Principal Executive Officer Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 12.1 CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Zheng Wei, certify that: 1. I have reviewed this annual report on Form 20-F of Connect Biopharma Holdings Limited (the "Company"); 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the

April 11, 2023 EX-13

Principal Financial Officer Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 13.2 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the annual report of Connect Biopharma Holdings Limited (the “Company”) on Form 20-F for the year ended December 31, 2022, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Steven Chan, Chief Financial Office

April 11, 2023 EX-15

Submission under Item 16.I.(a) of Form 20-F in relation to the Holding Foreign Companies Accountable Act.

Exhibit 15.2 April 11, 2023 VIA EDGAR Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: Connect Biopharma Holdings Limited Submission under the Item 16I(a) of Form 20-F Attn: Division of Corporation Finance Office of Life Sciences To the addressees set forth above: In compliance with the Holding Foreign Companies Accountable Act, Conn

March 21, 2023 EX-99

Late-Breaking Abstract and Oral Presentation at American Academy of Dermatology Annual Meeting

Exhibit 99.2 Connect Biopharma CBP-201 Atopic Dermatitis China Pivotal Study Showed Rapid Relief of Patient Symptoms March 18, 2023 Late-Breaking Abstract and Oral Presentation at American Academy of Dermatology Annual Meeting • Stage 1 of ongoing 52-week China pivotal AD trial met primary and secondary endpoints • No efficacy plateau at Week 16 SAN DIEGO & TAICANG, China & SUZHOU, China-(BUSINESS

March 21, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address of p

March 21, 2023 EX-99

ePoster and Oral Presentation at American Academy of Dermatology Annual Meeting

Exhibit 99.1 Connect Biopharma CBP-201 Atopic Dermatitis Global Phase 2b Data Showed Rapid and Sustained Improvement Across all Body Regions March 17, 2023 ePoster and Oral Presentation at American Academy of Dermatology Annual Meeting SAN DIEGO & TAICANG, China & SUZHOU, China-(BUSINESS WIRE)-March 17, 2023 – Connect Biopharma Holdings Limited (Nasdaq: CNTB) (Connect Biopharma or the Company), a

February 14, 2023 SC 13G/A

CNTB / Connect Biopharma Holdings Limited / Qiming Venture Partners V, L.P. - FORM SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A (Amendment No. 1)* Under the Securities Exchange Act of 1934 Connect Biopharma Holdings Limited (Name of Issuer) Ordinary shares, par value US$0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appropria

February 13, 2023 SC 13G

CNTB / Connect Biopharma Holdings Limited / Shanghai Minhui Enterprise Management Consulting Partnership (Limited Partnership) - SC 13G Passive Investment

SC 13G 1 minhui13g20221231.htm SC 13G Securities and Exchange Commission Washington, D.C. 20549 —————————————— Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* —————————————— Connect Biopharma Holdings Limited (Name of Is

February 13, 2023 SC 13G/A

CNTB / Connect Biopharma Holdings Limited / Wei Zheng - SC 13G/A Passive Investment

SC 13G/A 1 zhengwei13ga20221231.htm SC 13G/A Securities and Exchange Commission Washington, D.C. 20549 —————————————— Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* —————————————— Connect Biopharma Holdings Limited (Na

February 13, 2023 SC 13G/A

CNTB / Connect Biopharma Holdings Limited / BioFortune Inc - SC 13G/A Passive Investment

SC 13G/A 1 biofortune13ga20221231.htm SC 13G/A Securities and Exchange Commission Washington, D.C. 20549 —————————————— Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* —————————————— Connect Biopharma Holdings Limited (

February 13, 2023 EX-99

JOINT FILING AGREEMENT

EX-99 2 cntb-ex9999.htm EX-99.99 Exhibit 99 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the

February 13, 2023 EX-99

Joint Filing Agreement.

EX-99 2 cntb-ex9999.htm EX-99.99 Exhibit 99 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the

February 9, 2023 EX-99.1

Connect Biopharma Reports CBP-201 Global Phase 2 Asthma Trial Achieves Full Enrollment

Exhibit 99.1 Connect Biopharma Reports CBP-201 Global Phase 2 Asthma Trial Achieves Full Enrollment SAN DIEGO and TAICANG, SUZHOU, China – February 9, 2023 – Connect Biopharma Holdings Limited (Nasdaq: CNTB) (Connect Biopharma or the Company), a global clinical-stage biopharmaceutical company developing T cell-driven therapies to treat inflammatory diseases, today announced that its CBP-201 Phase

February 9, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address o

February 3, 2023 6-K

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2023 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant's name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address o

January 3, 2023 EX-99

JOINT FILING AGREEMENT

EX-99 2 d422740dex99.htm EX-99 Exhibit 99 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the i

January 3, 2023 SC 13G

CNTB / Connect Biopharma Holdings Limited / Huang James - SC 13G Passive Investment

SC 13G 1 d422740dsc13g.htm SC 13G Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary Shares (Title of Cl

December 30, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2022 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130(Address of

December 30, 2022 EX-99.1

Connect Biopharma Provides Business and Clinical Development Program Update Cash runway now expected to extend into at least 2025 as a result of revised timeline of global Phase 3 program of CBP-201 in atopic dermatitis (AD); Longer cash runway permi

Exhibit 99.1 Connect Biopharma Provides Business and Clinical Development Program Update Cash runway now expected to extend into at least 2025 as a result of revised timeline of global Phase 3 program of CBP-201 in atopic dermatitis (AD); Longer cash runway permits continued evaluation of potential partnership opportunities to advance the global AD Phase 3 program Progress of China pivotal AD tria

December 2, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2022 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address o

October 4, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2022 Commission File Number: 001-40

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address of

September 13, 2022 EX-99.1

Connect Biopharma Reports First Half 2022 Financial Results and Provides Business Update – Company expects to report top-line data from China pivotal trial for lead drug candidate CBP-201 in atopic dermatitis in October 2022– – Company to Host Confer

EXHIBIT 99.1 Connect Biopharma Reports First Half 2022 Financial Results and Provides Business Update ? Company expects to report top-line data from China pivotal trial for lead drug candidate CBP-201 in atopic dermatitis in October 2022? ? Company to Host Conference Call Today at 4:30 p.m. ET ? SAN DIEGO and TAICANG, SUZHOU, China ? September 13, 2022 ? Connect Biopharma Holdings Limited (Nasdaq:

September 13, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2022 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address

August 30, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2022 Commission File Number: 001-402

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address of

August 19, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2022 Commission File Number: 001-402

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address of

July 11, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2022 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) 12265 El Camino Real, Suite 350 San Diego, CA 92130 (Address of pr

July 1, 2022 S-8

As filed with the Securities and Exchange Commission on July 1, 2022

As filed with the Securities and Exchange Commission on July 1, 2022 Registration No.

July 1, 2022 CORRESP

Connect Biopharma Holdings Limited Science and Technology Park East R&D Building, 3rd Floor 6 Beijing West Road, Taicang Jiangsu Province, China 215400

Connect Biopharma Holdings Limited Science and Technology Park East R&D Building, 3rd Floor 6 Beijing West Road, Taicang Jiangsu Province, China 215400 July 1, 2022 VIA EDGAR Ms.

July 1, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Connect Biopharma Holdings Limited (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title(1) Fee Calculation or Carry Forward Rule Amount Registered(2) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial effective date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to be paid Equity Ordinary shares, par value US$0.

June 17, 2022 CORRESP

*********

CORRESP 1 filename1.htm 12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Austin Moscow Beijing Munich Boston New York Brussels Orange County Century City Paris June 17, 2022 Chicago Riyadh Dubai San Diego Düsseldorf San Francisco Frankfurt Seoul VIA EDGAR Hamburg Shanghai Hong Kong Silicon Valley Ms. Jane Park Houston

June 17, 2022 F-3/A

As filed with the Securities and Exchange Commission on June 17, 2022

Table of Contents As filed with the Securities and Exchange Commission on June 17, 2022 Registration No.

June 17, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2022 Commission File Number: 001-40212

6-K 1 d474156d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) Science and Technology Park East R&D Buil

June 10, 2022 EX-99.1

Forward-Looking Statements This presentation regarding Connect Biopharma Holdings Limited ("Connect," "we," "us" or "our") has been prepared solely for informational purposes. Certain information contained in this presentation relates to, or is based

Jefferies Conference Presentation ? June 10, 2022 NASDAQ: CNTB DEVELOPING NEXT- GENERATION THERAPEUTICS FOR T CELL DRIVEN INFLAMMATORY DISEASES Exhibit 99.

June 10, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2022 Commission File Number: 001-40212

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3

May 23, 2022 F-3/A

As filed with the Securities and Exchange Commission on May 20, 2022

Table of Contents As filed with the Securities and Exchange Commission on May 20, 2022 Registration No.

May 20, 2022 CORRESP

*********

12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Austin Moscow Beijing Munich Boston New York Brussels Orange County Century City Paris May 20, 2022 Chicago Riyadh Dubai San Diego Düsseldorf San Francisco Frankfurt Seoul VIA EDGAR Hamburg Shanghai Hong Kong Silicon Valley Houston Singapore Ms. Jane Park London Tel Aviv

May 9, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijing

May 5, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijing

May 3, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijing

May 3, 2022 EX-99.2

Forward-Looking Statements This presentation regarding Connect Biopharma Holdings Limited ("Connect," "we," "us" or "our") has been prepared solely for informational purposes. Certain information contained in this presentation relates to, or is based

CBP-307 Top-line Phase 2 Results in Ulcerative Colitis Exhibit 99.2 Forward-Looking Statements This presentation regarding Connect Biopharma Holdings Limited ("Connect," "we," "us" or "our") has been prepared solely for informational purposes. Certain information contained in this presentation relates to, or is based on, studies, publications, surveys and other data obtained from third-party sourc

May 3, 2022 EX-99.1

Connect Biopharma Announces Week 12 Top-Line Results from Phase 2 CBP-307 Trial in Patients with Moderate-to-Severe Ulcerative Colitis

Exhibit 99.1 FOR IMMEDIATE RELEASE Connect Biopharma Announces Week 12 Top-Line Results from Phase 2 CBP-307 Trial in Patients with Moderate-to-Severe Ulcerative Colitis ? Primary endpoint of change from baseline on adapted Mayo Score for CBP-307 0.2 mg once-daily, orally administered dose showed a numerical improvement, but did not achieve statistical significance ? Clinical Remission on adapted

April 15, 2022 F-3

Powers of Attorney (included on signature page to the registration statement)

Table of Contents As filed with the Securities and Exchange Commission on April 15, 2022 Registration No.

April 15, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form F-3 (Form Type) Connect Biopharma Holdings Limited (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial effective date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Fees to be paid Equity Ordinary shares, par value US$0.

April 15, 2022 EX-1.2

Sales Agreement, dated April 15, 2022, between Connect Biopharma Holdings Limited, SVB Securities LLC and Cantor Fitzgerald & Co.

Exhibit 1.2 Connect Biopharma Holdings Limited $150,000,000 of American Depositary Shares Each Representing One Ordinary Share (Par Value $0.000174 Per Share) SALES AGREEMENT April 15, 2022 SVB SECURITIES LLC 1301 Avenue of the Americas, 12th Floor New York, New York 10019 CANTOR FITZGERALD & CO. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: Connect Biopharma Holdings Limited, an exempt

March 31, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission File Number: 001-4021

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijin

March 31, 2022 EX-15.1

Consent of PricewaterhouseCoopers Zhong Tian LLP, an independent registered public accounting firm.

Exhibit 15.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (No. 333-254524) of Connect Biopharma Holdings Limited of our report dated March 31, 2022 relating to the financial statements, which appears in this Form 20-F. /s/ PricewaterhouseCoopers Zhong Tian LLP Beijing, the People?s Republic of

March 31, 2022 EX-13.2

Principal Financial Officer Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 13.2 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the annual report of Connect Biopharma Holdings Limited (the “Company”) on Form 20-F for the year ended December 31, 2021, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Steven Chan, Chief Financial Office

March 31, 2022 EX-13.1

Principal Executive Officer Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 13.1 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the annual report of Connect Biopharma Holdings Limited (the “Company”) on Form 20-F for the year ended December 31, 2021, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Zheng Wei, Chief Executive Officer

March 31, 2022 20-F

Form 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F ? REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE SECURITIES EXCHANGE ACT O

March 31, 2022 EX-99.1

Connect Biopharma Reports Full Year 2021 Financial Results and Provides Business Update - Global Phase 3 Trial of CBP-201 in Moderate-to-Severe Atopic Dermatitis Expected to Commence in H2 2022 - - Topline Phase 2 CBP-307 Results in Moderate-to-Sever

Exhibit 99.1 FOR IMMEDIATE RELEASE Connect Biopharma Reports Full Year 2021 Financial Results and Provides Business Update - Global Phase 3 Trial of CBP-201 in Moderate-to-Severe Atopic Dermatitis Expected to Commence in H2 2022 - - Topline Phase 2 CBP-307 Results in Moderate-to-Severe Ulcerative Colitis (UC) Expected to Be Reported in H1 2022 - - Cash Balance of RMB 1,706.9 million (USD 267.7 mil

March 31, 2022 EX-4.5

Non-Employee Director Compensation Program

Exhibit 4.5 connect biopharma holdings limited NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM Eligible Directors (as defined below) on the board of directors (the ?Board?) of Connect Biopharma Holdings Limited (the ?Company?) shall be eligible to receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this ?Program?). The cash and equity compensation descr

March 31, 2022 EX-1.1

Fifth Amended and Restated Memorandum and Articles of Association, as currently in effect

Exhibit 1.1 THE COMPANIES ACT (AS REVISED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FIFTH AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF CONNECT BIOPHARMA HOLDINGS LIMITED (adopted by a Special Resolution passed on March 12, 2021 and effective immediately prior to the completion of the initial public offering of the Company?s American Depositary Shares representing its Ordinary Shares) 1

March 31, 2022 EX-4.12

English translation of House Lease Contract, dated April 9, 2021, between Suzhou Connect Biopharma Co., Ltd. and Taicang Science and Technology Venture Park Co., Ltd.

Exhibit 4.12 House Lease Contract Lessor: Taicang Science and Technology Venture Park Co., Ltd. (hereinafter referred to as ?Party A?) Lessee: Suzhou Connect Biopharmaceuticals, Ltd. (hereinafter referred to as ?Party B?) In accordance with the ?Civil Code of the People's Republic of China? and relevant provisions, in order to define the rights and obligations of the Lessor and the Lessee, Party A

March 31, 2022 EX-4.13

Lease Contract, effective as of December 22, 2021, between Connect Biopharm LLC and Paseo Del Mar LLC

Exhibit 4.13 LEASE BETWEEN PASEO DEL MAR LLC AND CONNECT BIOPHARM LLC LEASE (Short Form) THIS LEASE is made as of December 22, 2021 , by and between PASEO DEL MAR LLC, a Delaware limited liability company, hereafter called ?Landlord,? and CONNECT BIOPHARM LLC, a California limited liability company hereafter called ?Tenant.? ARTICLE 1. BASIC LEASE PROVISIONS Each reference in this Lease to the ?Ba

March 31, 2022 EX-12.1

Principal Executive Officer Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 12.1 CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Zheng Wei, certify that: 1. I have reviewed this annual report on Form 20-F of Connect Biopharma Holdings Limited; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made,

March 31, 2022 EX-12.2

Principal Financial Officer Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 12.2 CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Steven Chan, certify that: 1. I have reviewed this annual report on Form 20-F of Connect Biopharma Holdings Limited; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements mad

March 31, 2022 EX-2.5

Description of Securities

Exhibit 2.5 Description of rights of securities registered under Section 12 of the Securities Exchange Act of 1934 (the ?Exchange Act?) American Depositary Shares (?ADSs?), each of which represents one ordinary share of Connect Biopharma Holdings Limited (?we,? ?us,? ?our company,? or ?our?), are listed and traded on the on the Nasdaq Global Market and, in connection with this listing (but not for

March 31, 2022 EX-4.10

Employment Letter, dated October 13, 2021, between Connect Biopharm LLC and Steven Chan

Exhibit 4.10 October 13, 2021 Steven Chan Via Electronic Mail Re: Employment Terms Dear Steven: Connect Biopharm LLC (the ?Company? or ?Connect?) is pleased to offer you the position of Chief Financial Officer of the Company and its affiliates, on the following terms. As applicable, references to Company or Connect also include its affiliated entities. You will be responsible for fully contributin

March 31, 2022 EX-4.11

Employment Letter, dated November 2, 2021, between Connect Biopharm LLC and Chin Lee, M.D.

Exhibit 4.11 November 2, 2021 Chin Lee Via Electronic Mail Re: Employment Terms Dear Chin: Connect Biopharm LLC (the ?Company? or ?Connect?) is pleased to offer you the position of Chief Medical Officer of the Company and its affiliates, on the following terms. As applicable, references to Company or Connect also include its affiliated entities. You will be responsible for providing medical and tr

March 1, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission File Number: 001-4021

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijin

February 25, 2022 SC 13G

CNTB / Connect Biopharma Holdings Limited / Wei Zheng - SC 13G Passive Investment

Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to ? 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to ? 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class

February 25, 2022 SC 13G

CNTB / Connect Biopharma Holdings Limited / BioFortune Inc - SC 13G Passive Investment

Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to ? 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to ? 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class

February 25, 2022 EX-99

JOINT FILING AGREEMENT

EX-99 2 d300001dex99.htm EX-99 Exhibit 99 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the i

February 16, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2022 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Bei

February 16, 2022 EX-99.1

Forward-Looking Statements This presentation regarding Connect Biopharma Holdings Limited ("Connect," "we," "us" or "our") has been prepared solely for informational purposes. Certain information contained in this presentation relates to, or is based

Leerink Conference Presentation ? February 2022 NASDAQ: CNTB DEVELOPING NEXT-GENERATION THERAPEUTICS FOR T CELL DRIVEN INFLAMMATORY DISEASES Exhibit 99.

February 15, 2022 SC 13G

CNTB / Connect Biopharma Holdings Limited / Advantech Capital II L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value US$0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate

February 15, 2022 EX-99.1

Joint Filing Agreement

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the ordinary shares of Connect Biopharma Holdings Ltd. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13G. Each of the undersigned acknowledges that each shall be responsible for the timely fili

February 14, 2022 SC 13G

CNTB / Connect Biopharma Holdings Limited / Qiming Venture Partners VII, L.P. - FORM SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* Connect Biopharma Holdings Limited (Name of Issuer) Ordinary shares, par value US$0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

January 5, 2022 EX-99.2

2 2 Forward-Looking Statements • This presentation regarding Connect Biopharma Holdings Limited ( Connect, we, us or our ) has been prepared solely for informational purposes. • Certain information contained in this presentation relates to, or is bas

Exhibit 99.2 C B P - 2 0 1 -WW001 G l o b a l P h a s e 2 b T r i a l i n A t o p i c D e r m a t i t i s T o p l i n e R e s u l t s NEXT-GENERATION THERAPEUTICS FOR T CELL-DRIVEN INFLAMMATORY DISEASES th Conference Call - 5 January 2022 2 2 Forward-Looking Statements ? This presentation regarding Connect Biopharma Holdings Limited ( Connect, we, us or our ) has been prepared solely for informati

January 5, 2022 EX-99.1

Connect Biopharma Reports Detailed Positive Dataset from the Global Phase 2b Trial of CBP-201 in Adult Patients with Moderate-to-Severe Atopic Dermatitis —Phase 2b trial previously reported achievement of both primary and key secondary end points, de

Exhibit 99.1 Connect Biopharma Reports Detailed Positive Dataset from the Global Phase 2b Trial of CBP-201 in Adult Patients with Moderate-to-Severe Atopic Dermatitis ?Phase 2b trial previously reported achievement of both primary and key secondary end points, demonstrating significant improvements in skin clearance, disease severity, and itch compared to placebo? ?Additional analyses demonstrate

January 5, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2022 Commission File Number: 001-40

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2022 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beij

November 22, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Bei

November 19, 2021 EX-99.1

Connect Biopharma Completes Enrollment of CBP-307 Global Phase 2 Clinical Trial in Moderate-to-Severe Ulcerative Colitis

Exhibit 99.1 Connect Biopharma Completes Enrollment of CBP-307 Global Phase 2 Clinical Trial in Moderate-to-Severe Ulcerative Colitis SAN DIEGO, CA and TAICANG, SUZHOU, China, Nov. 19, 2021 ? Connect Biopharma Holdings Limited (Nasdaq: CNTB) (?Connect Biopharma? or the ?Company?), a global clinical-stage biopharmaceutical company dedicated to improving the lives of patients with chronic inflammato

November 19, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission File Number: 001-4

6-K 1 d66201d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) Science and Technology Park East R&D B

November 19, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Bei

November 19, 2021 EX-99.1

Connect Biopharma Reports Positive Top-Line Results from the Global Phase 2 Clinical Trial of CBP-201 in Patients with Moderate-to-Severe Atopic Dermatitis Primary endpoint met with all three CBP-201 arms achieving significant improvements Significan

Exhibit 99.1 Connect Biopharma Reports Positive Top-Line Results from the Global Phase 2 Clinical Trial of CBP-201 in Patients with Moderate-to-Severe Atopic Dermatitis Primary endpoint met with all three CBP-201 arms achieving significant improvements Significant improvements also reported for key secondary endpoints including other measures of skin clearance and itch with CBP-201 300mg every two

September 8, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2021 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Be

September 8, 2021 EX-99.1

Connect Biopharma Announces First Subject Dosed in Phase 2 Trial Evaluating CBP-201 in Adult Patients with Chronic Rhinosinusitis with Nasal Polyps

Exhibit 99.1 Connect Biopharma Announces First Subject Dosed in Phase 2 Trial Evaluating CBP-201 in Adult Patients with Chronic Rhinosinusitis with Nasal Polyps SAN DIEGO, CA and TAICANG, SUZHOU, China ? September 8th 2021 ? Connect Biopharma Holdings Limited (Nasdaq: CNTB) (?Connect Biopharma? or the ?Company?), a global clinical-stage biopharmaceutical company dedicated to improving the lives of

September 2, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2021 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Be

September 2, 2021 EX-99.1

Connect Biopharma Announces First Patient Dosed in China Pivotal Trial Evaluating CBP-201 in Adults with Moderate-to-Severe Atopic Dermatitis

Exhibit 99.1 Connect Biopharma Announces First Patient Dosed in China Pivotal Trial Evaluating CBP-201 in Adults with Moderate-to-Severe Atopic Dermatitis SAN DIEGO, CA and TAICANG, SUZHOU, China ? September 2nd 2021 ? Connect Biopharma Holdings Limited (Nasdaq: CNTB) (?Connect Biopharma? or the ?Company?), a global clinical-stage biopharmaceutical company dedicated to improving the lives of patie

August 31, 2021 EX-99.2

MANAGEMENT’S DISCUSSIONS AND ANALYSIS OF FINANCIAL CONDITIONS AND RESULTS OF OPERATIONS

Exhibit 99.2 MANAGEMENT?S DISCUSSIONS AND ANALYSIS OF FINANCIAL CONDITIONS AND RESULTS OF OPERATIONS You should read the following discussion and analysis of our financial condition and results of operations in conjunction with our unaudited interim condensed consolidated financial statements, including the notes thereto, included with this report and our audited financial statements included in o

August 31, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2021 Commission File Number: 001-402

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beiji

August 31, 2021 EX-99.1

CONNECT BIOPHARMA HOLDINGS LIMITED INDEX TO THE UNAUDITED INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS Page Unaudited Interim Condensed Consolidated Statements of Loss for the six months ended June 30, 2020 and 2021 2 Unaudited Interim Condens

Exhibit 99.1 CONNECT BIOPHARMA HOLDINGS LIMITED INDEX TO THE UNAUDITED INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS Page Unaudited Interim Condensed Consolidated Statements of Loss for the six months ended June 30, 2020 and 2021 2 Unaudited Interim Condensed Consolidated Statements of Comprehensive Loss for the six months ended June 30, 2020 and 2021 3 Unaudited Interim Condensed Consolidat

August 31, 2021 EX-99.3

Connect Biopharma Provides Business Update and Reports First Half 2021 Financial Results - On Track to Report CBP-201 Phase 2B Top-Line Data Evaluating Moderate-to-Severe Atopic Dermatitis (AD) in Q4 of 2021 - - Cash Balance of RMB 2,025.0 Million (U

Exhibit 99.3 Connect Biopharma Provides Business Update and Reports First Half 2021 Financial Results - On Track to Report CBP-201 Phase 2B Top-Line Data Evaluating Moderate-to-Severe Atopic Dermatitis (AD) in Q4 of 2021 - - Cash Balance of RMB 2,025.0 Million (USD 313.5 Million) at June 30, 2021 - SAN DIEGO, CA and TAICANG, SUZHOU, China ? August 31, 2021 ? Connect Biopharma Holdings Limited (Nas

August 27, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2021 Commission File Number: 001-402

6-K 1 d206243d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) Science and Technology Park East R&D Bu

June 16, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2021 Commission File Number: 001-40212

6-K 1 d194451d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) Science and Technology Park East R&D Buil

June 7, 2021 SC 13D/A

CNTB / Connect Biopharma Holdings Limited / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone:

June 3, 2021 EX-99.1

Connect Biopharma Announces First Subject Dosed in Phase I Trial Evaluating Safety, Tolerability and Pharmacokinetic Profile of

Exhibit 99.1 Connect Biopharma Announces First Subject Dosed in Phase I Trial Evaluating Safety, Tolerability and Pharmacokinetic Profile of CBP-174 in Healthy Adult Subjects Development program exploring the potential of CBP-174 in the treatment of chronic inflammatory pruritus SAN DIEGO and TAICANG, SUZHOU, China, May 25, 2021 (GLOBE NEWSWIRE) ? Connect Biopharma Holdings Limited (Nasdaq: CNTB)

June 3, 2021 EX-99.2

2 Forward-Looking Statements • Certain information contained in this presentation relates to, or is based on, studies, publications, surveys and other data obtained from third-party sources and Connect’s own internal estimates and research. While we

Exhibit 99.2 DEVELOPING NEXT-GENERATION THERAPEUTICS FOR T CELL DRIVEN INFLAMMATORY DISEASES Corporate Presentation - June 2021 NASDAQ: CNTBExhibit 99.2 DEVELOPING NEXT-GENERATION THERAPEUTICS FOR T CELL DRIVEN INFLAMMATORY DISEASES Corporate Presentation - June 2021 NASDAQ: CNTB 2 Forward-Looking Statements ? Certain information contained in this presentation relates to, or is based on, studies,

June 3, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2021 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijing

May 17, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2021 Commission File Number: 001-40212

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant?s name into English) Science and Technology Park East R&D Building, 3rd Floor 6 Beijing

May 17, 2021 EX-99.1

Connect Biopharma Announces First

Exhibit 99.1 Connect Biopharma Announces First Patient Dosed in Phase 2 Trial Evaluating CBP-201 in Adults with Moderate-to-Severe Persistent Asthma SAN DIEGO and TAICANG, China, May 12, 2021 (GLOBE NEWSWIRE) ? Connect Biopharma Holdings Limited (Nasdaq: CNTB) (?Connect Biopharma? or the ?Company?), a global clinical-stage biopharmaceutical company dedicated to improving the lives of patients with

May 11, 2021 6-K

Current Report of Foreign Issuer - 6-K

6-K 1 d507119d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2021 Commission File Number: 001-40212 Connect Biopharma Holdings Limited (Translation of registrant’s name into English) Science and Technology Park East R&D Build

March 29, 2021 SC 13D

Under the Securities Exchange Act of 1934 (Amendment ___)* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Stree

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment )* CONNECT BIOPHARMA HOLDINGS LIMITED (Name of Issuer) Ordinary shares, par value $0.000174 per share (Title of Class of Securities) 207523101** (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.7

March 29, 2021 EX-1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of March 29, 2021, is by and among RA Capital Management, L.

March 19, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 19, 2021 Registration No.

March 19, 2021 EX-4.3

Deposit Agreement, among Connect Biopharma Holdings Limited, the depositary, and the holders and beneficial owners of American Depositary Shares issued thereunder

Exhibit 4.3 DEPOSIT AGREEMENT by and among CONNECT BIOPHARMA HOLDINGS LIMITED as Issuer, DEUTSCHE BANK TRUST COMPANY AMERICAS as Depositary, AND THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS ISSUED HEREUNDER Dated as of March 18, 2021 DEPOSIT AGREEMENT DEPOSIT AGREEMENT, dated as of March 18, 2021, by and among (i) Connect Biopharma Holdi

March 19, 2021 424B4

11,250,000 American Depositary Shares Representing 11,250,000 Ordinary Shares

Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No. 333-253631 Registration No. 333-254476 PROSPECTUS 11,250,000 American Depositary Shares Representing 11,250,000 Ordinary Shares This is an initial public offering of American Depositary Shares, or ADSs, of Connect Biopharma Holdings Limited. We are selling 11,250,000 ADSs, representing 11,250,000 ordinary shares. Each ADS represen

March 18, 2021 EX-8.3

Opinion of Latham & Watkins LLP regarding certain US tax matters

Exhibit 8.3 355 South Grand Avenue, Suite 100 Los Angeles, California 90071-1560 Tel: +1.213.485.1234 Fax: +1.213.891.8763 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh D?sseldorf San Diego Frankfurt San Francisco Hamburg Seoul Hong Kong Shanghai Houston Silicon Valley London Singapore Los Angeles Tokyo Madr

March 18, 2021 F-1/A

- F-1/A

Table of Contents As filed with the Securities and Exchange Commission on March 18, 2021 Registration No.

March 18, 2021 F-1MEF

- F-1MEF

As filed with the Securities and Exchange Commission on March 18, 2021 Registration No.

March 17, 2021 EX-10.3

Form of 2021 Incentive Award Plan and form of share option grant notice and share option agreement thereunder

EX-10.3 4 d295873dex103.htm EX-10.3 Exhibit 10.3 CONNECT BIOPHARMA HOLDINGS LIMITED 2021 STOCK INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel, to provide additional incentives to Employees, Directors and Consultants and to promote the success of the Company’s business. 2. Definitions. The following definitions shall apply as

March 17, 2021 CORRESP

*********

March 17, 2021 VIA EDGAR Ms. Ada D. Sarmento Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris D

March 17, 2021 EX-99.2

Opinion of Han Kun Law Offices regarding certain PRC tax matters (included in Exhibit 99.2)

Exhibit 99.2 33/F, HKRI Centre Two, HKRI Taikoo Hui, 288 Shimen Road (No. 1), Jing?an District Shanghai 200041, PRC Tel: +86 21 6080 0909 Fax: +86 21 6080 0999 Beijing ? Shanghai ? Shenzhen ? Hong Kong www.hankunlaw.com March 17, 2021 To: Connect Biopharma Holdings Limited (the ?Company?) Science and Technology Park, East R&D Building, 3rd Floor 6 Beijing West Road, Taicang, Jiangsu Province, Chin

March 17, 2021 EX-8.3

Opinion of Latham & Watkins LLP regarding certain US tax matters

Exhibit 8.3 355 South Grand Avenue, Suite 100 Los Angeles, California 90071-1560 Tel: +1.213.485.1234 Fax: +1.213.891.8763 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh D?sseldorf San Diego Frankfurt San Francisco Hamburg Seoul Hong Kong Shanghai Houston Silicon Valley London Singapore Los Angeles Tokyo Madr

March 17, 2021 F-1/A

- F-1/A

As filed with the Securities and Exchange Commission on March 17, 2021 Registration No.

March 16, 2021 CORRESP

Connect Biopharma Holdings Limited Science and Technology Park East R&D Building, 3rd Floor 6 Beijing West Road, Taicang Jiangsu Province, China 215400

Connect Biopharma Holdings Limited Science and Technology Park East R&D Building, 3rd Floor 6 Beijing West Road, Taicang Jiangsu Province, China 215400 March 16, 2021 VIA EDGAR Ms.

March 16, 2021 CORRESP

[Signature page follows]

Jefferies LLC 520 Madison Avenue New York, New York 10022 SVB Leerink LLC 255 California Street, 12th Floor San Francisco, California 94111 Piper Sandler & Co.

March 12, 2021 EX-99.2

Opinion of Han Kun Law Offices regarding certain PRC tax matters (included in Exhibit 99.2)

Exhibit 99.2 March 12, 2021 To: Connect Biopharma Holdings Limited (the ?Company?) Science and Technology Park, East R&D Building, 3rd Floor 6 Beijing West Road, Taicang, Jiangsu Province, China Dear Sirs or Madams: We are lawyers qualified in the People?s Republic of China (the ?PRC? or ?China?, which, for purposes of this opinion only, does not include the Hong Kong Special Administrative Region

March 12, 2021 EX-4.2

Form of Deposit Agreement, among the Registrant, the depositary, and the holders and beneficial owners of American Depositary Shares issued thereunder

Exhibit 4.2 DEPOSIT AGREEMENT by and among CONNECT BIOPHARMA HOLDINGS LIMITED as Issuer, DEUTSCHE BANK TRUST COMPANY AMERICAS as Depositary, AND THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS ISSUED HEREUNDER Dated as of March [?], 2021 DEPOSIT AGREEMENT DEPOSIT AGREEMENT, dated as of March [?], 2021, by and among (i) Connect Biopharma Hol

March 12, 2021 EX-4.1

Specimen Certificate for Ordinary Shares

Exhibit 4.1 Connect Biopharma Holdings Limited - Ordinary Shares (Incorporated under the laws of the Cayman Islands) Number Shares Share Capital is US$76,560 divided into (i) 400,000,000 Ordinary Shares of a nominal or par value of US$0.000174 each (ii) 40,000,000 Preferred Shares of a nominal or par value of US$0.000174 each THIS IS TO CERTIFY THAT is the registered holder of Ordinary Shares in t

March 12, 2021 EX-10.4

2021 Employee Share Purchase Plan

Exhibit 10.4 CONNECT BIOPHARMA HOLDINGS LIMITED 2021 EMPLOYEE SHARE PURCHASE PLAN ARTICLE I. PURPOSE The purpose of this Plan is to assist Eligible Employees of the Company and its Designated Subsidiaries in acquiring a share ownership interest in the Company. The Plan consists of two components: (i) the Section 423 Component and (ii) the Non-Section 423 Component. The Section 423 Component is int

March 12, 2021 EX-10.2

Form of Indemnification Agreement, between the Registrant and its directors and executive officers

Exhibit 10.2 FORM OF INDEMNIFICATION AGREEMENT THIS INDEMNIFICATION AGREEMENT (the ?Agreement?) is made and entered into this , 2021, between Connect Biopharma Holdings Limited, a Cayman Islands company (the ?Company?), and (the ?Indemnitee?). A. The Company and the Indemnitee recognize the continued difficulty in obtaining liability insurance for corporate directors, officers, employees, controll

March 12, 2021 EX-4

DEPOSIT AGREEMENT by and among CONNECT BIOPHARMA HOLDINGS LIMITED as Issuer, DEUTSCHE BANK TRUST COMPANY AMERICAS as Depositary, THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS ISSUED HEREUNDE

EX-4 2 a21-12ex-4.htm EX. (A) FORM OF DEPOSIT AGREEMENT DEPOSIT AGREEMENT by and among CONNECT BIOPHARMA HOLDINGS LIMITED as Issuer, DEUTSCHE BANK TRUST COMPANY AMERICAS as Depositary, AND THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS ISSUED HEREUNDER Dated as of March [●], 2021 DEPOSIT AGREEMENT DEPOSIT AGREEMENT, dated as of March [●],

March 12, 2021 EX-99.1

Code of Business Conduct and Ethics of the Registrant

Exhibit 99.1 CONNECT BIOPHARMA HOLDINGS LIMITED CODE OF BUSINESS CONDUCT AND ETHICS I. INTRODUCTION A. Purpose This Code of Business Conduct and Ethics (the ?Code?) contains general guidelines for conducting the business of Connect Biopharma Holdings Limited (the ?Company? or ?we?) consistent with the highest standards of business ethics. To the extent this Code requires a higher standard than req

March 12, 2021 F-1/A

- F-1/A

Table of Contents As filed with the Securities and Exchange Commission on March 12, 2021 Registration No.

March 12, 2021 EX-3.2

Amended and Restated Memorandum and Articles of Association of the Registrant (incorporated by reference to Exhibit 3.2 to Amendment No. 1 to the Registrant’s registration statement on Form F-1 (File No. 333-253631) filed with the Commission on March 12, 2021)

Exhibit 3.2 THE COMPANIES ACT (AS REVISED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FIFTH AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF CONNECT BIOPHARMA HOLDINGS LIMITED (adopted by a Special Resolution passed on 2021 and effective immediately prior to the completion of the initial public offering of the Company?s American Depositary Shares representing its Ordinary Shares) 1. The name

March 12, 2021 EX-1.1

Form of Underwriting Agreement

EX-1.1 2 d295873dex11.htm EX-1.1 Exhibit 1.1 Connect Biopharma Holdings Limited [•] American Depositary Shares Representing [•] Ordinary Shares (Par Value $0.000174 Per Share) UNDERWRITING AGREEMENT [•], 2021 JEFFERIES LLC SVB LEERINK LLC PIPER SANDLER & CO. CHINA INTERNATIONAL CAPITAL CORPORATION HONG KONG SECURITIES LIMITED As Representatives of the several Underwriters c/o JEFFERIES LLC 520 Mad

March 12, 2021 8-A12B

Form 8-A

8-A12B 1 d154885d8a12b.htm 8-A12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 CONNECT BIOPHARMA HOLDINGS LIMITED (Exact name of registrant as specified in its charter) Cayman Islands Not Applicable (State or other jurisdiction of incorporati

March 12, 2021 EX-10.3

2021 Incentive Award Plan and form of share option grant notice and share option agreement thereunder

Exhibit 10.3 CONNECT BIOPHARMA HOLDINGS LIMITED 2021 STOCK INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel, to provide additional incentives to Employees, Directors and Consultants and to promote the success of the Company?s business. 2. Definitions. The following definitions shall apply as used herein and in the individual A

March 12, 2021 F-6

-

As filed with the Securities and Exchange Commission on March 12, 2021 Registration No.

March 9, 2021 CORRESP

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12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES March 9, 2021 VIA EDGAR Ms. Ada D. Sarmento Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission Beijing Boston Brussels Century City Chicago Dubai D?sseldorf Frankfurt Hamburg Hong Kong Houston London Los Angeles Madrid Milan M

March 8, 2021 CORRESP

FOIA Confidential Treatment Requested Under 17 C.F.R. § 200.83

140 Scott Drive Menlo Park, California 94025 Tel: +1.650.328.4600 Fax: +1.650.463.2600 www.lw.com FIRM / AFFILIATE OFFICES Abu Dhabi Milan Barcelona Moscow Beijing Munich Boston New Jersey Brussels New York Century City Orange County Chicago Paris March 8, 2021 Dubai Riyadh D?sseldorf Rome Frankfurt San Diego Hamburg San Francisco Hong Kong Shanghai Houston Silicon Valley London Singapore Los Ange

February 26, 2021 EX-10.12

Employment Agreement, effective as of January 1, 2021, between Connect Biopharma HongKong Limited and Wubin Pan, Ph.D.

Exhibit 10.12 EXECUTION VERSION February 26, 2021 CONNECT BIOPHARMA HONGKONG LIMITED and WUBIN PAN EXECUTIVE EMPLOYMENT AGREEMENT CONTENTS Clause Page 1. DEFINITIONS 1 2. DATE OF COMMENCEMENT AND DURATION 4 3. APPOINTMENT AND DUTIES 5 4. MOBILITY 5 5. REMUNERATION AND OTHER BENEFITS 5 6. CONFIDENTIAL INFORMATION 8 7. RECEIPT OF PAYMENTS AND BENEFITS FROM THIRD PARTIES 9 8. EARLY TERMINATION OF APP

February 26, 2021 EX-4.4

Second Amended and Restated Shareholders Agreement, dated as of December 1, 2020, between Connect Biopharma Holdings Limited, its subsidiaries and certain of its shareholders

Exhibit 4.4 SECOND AMENDED AND RESTATED SHAREHOLDERS AGREEMENT This SECOND AMENDED AND RESTATED SHAREHOLDERS AGREEMENT (this ?Agreement?) is entered into on December 1, 2020 by and among: 1. Connect Biopharma Holdings Limited, an exempted company incorporated under the laws of the Cayman Islands (the ?Company?); 2. Connect Biopharma Hong Kong Limited, a limited liability company incorporated under

February 26, 2021 EX-10.14

Employment Letter Agreement, dated January 19, 2021, by and between Connect Biopharm LLC and Selwyn Ho, MB BS, as amended

Exhibit 10.14 January 19, 2021 Selwyn Ho Via electronic delivery Re: Employment Terms Dear Selwyn: Connect Biopharm LLC (the ?Company?), a wholly-owned subsidiary of Connect Biopharma Holdings Limited (?Parent?), is pleased to offer you the position of Senior Vice President of Corporate Development and Chief Business Officer, on the following terms. The Company will work with you to file an applic

February 26, 2021 EX-10.10

English translation of House Lease Contract, dated August 1, 2020, between Suzhou Connect Biopharma Co., Ltd. and Taicang Science and Technology Venture Park Co., Ltd.

Exhibit 10.10 House Lease Contract Lessor: Taicang Science and Technology Venture Park Co., Ltd. (hereinafter referred to as ?Party A?) Lessee: Suzhou Connect Biopharmaceuticals, Ltd. (hereinafter referred to as ?Party B?) In accordance with the ? Contract Law of the People?s Republic of China? and relevant provisions, in order to define the rights and obligations of the Lessor and the Lessee, Par

February 26, 2021 EX-21.1

List of Subsidiaries

EX-21.1 17 d295873dex211.htm EX-21.1 Exhibit 21.1 List of Principal Subsidiaries of the Registrant Wholly Owned Subsidiary Place of Incorporation Connect Biopharma HongKong Limited Hong Kong Connect Biopharm LLC United States Connect Biopharma Australia PTY LTD Australia Suzhou Connect Biopharma Co., Ltd. People’s Republic of China Connect Biopharma (Beijing), Ltd People’s Republic of China Connec

February 26, 2021 EX-99.2

Opinion of Han Kun Law Offices regarding certain PRC tax matters (included in Exhibit 99.2)

Exhibit 99.2 February 26, 2021 To: Connect Biopharma Holdings Limited (the ?Company?) Science and Technology Park, East R&D Building, 3rd Floor 6 Beijing West Road, Taicang, Jiangsu Province, China Dear Sirs or Madams: We are lawyers qualified in the People?s Republic of China (the ?PRC? or ?China?, which, for purposes of this opinion only, does not include the Hong Kong Special Administrative Reg

February 26, 2021 EX-10.13

English translation of the Labor Contract, dated as of January 2, 2020, between the Registrant and Lei Sun, Ph.D.

Exhibit 10.13 Employment Contract (Full-time) Name of Party A (Employer): Suzhou Connect Biopharmaceuticals, Ltd. Address: No. 6 West Beijing Road, Taicang Economic Development Area Legal Representative (or Main Person in Charge): WUBIN PAN Name of Party B (Employee): Lei Sun Gender: Male [seal:] Suzhou Connect Biopharmaceuticals, Ltd. 3205851966705 Prepared and Printed by Taicang Municipal Labor

February 26, 2021 EX-10.1

Connect Biopharma Holdings Limited 2019 Stock Incentive Plan

Exhibit 10.1 Connect Biopharma Holdings Limited 2019 STOCK INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel, to provide additional incentives to Employees, Directors and Consultants and to promote the success of the Company?s business. 2. Definitions. The following definitions shall apply as used herein and in the individual A

February 26, 2021 EX-10.7

Amendment #2 to Exclusive License Agreement, dated as of February 23, 2018, between Arena Pharmaceuticals, Inc. and Connect Biopharm LLC

Exhibit 10.7 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. AMENDMENT #2 TO EXCLUSIVE LICENSE AGREEMENT This Amendment #2 (this ?Amendment?) is entered into as of February 23, 2018 (the ?Amendment Effective Date?) by a

February 26, 2021 EX-10.8

Amendment #3 to Exclusive License Agreement, dated as of November 19, 2020, between Arena Pharmaceuticals, Inc. and Connect Biopharm LLC

Exhibit 10.8 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed AMENDMENT #3 TO EXCLUSIVE LICENSE AGREEMENT This Amendment #3 (this ?Amendment?) is entered into as of November 19, 2020 (the ?Amendment Effective Date?), by a

February 26, 2021 EX-10.9

English translation of House Lease Contract, dated February 1, 2019, between Suzhou Connect Biopharma Co., Ltd. and Taicang Science and Technology Venture Park Co., Ltd.

Exhibit 10.9 House Lease Contract Lessor: Taicang Science and Technology Venture Park Co., Ltd. (hereinafter referred to as ?Party A?) Lessee: Suzhou Connect Biopharmaceuticals, Ltd. (hereinafter referred to as ?Party B?) In accordance with the ?Contract Law of the People?s Republic of China? and relevant provisions, in order to define the rights and obligations of the Lessor and the Lessee, Party

February 26, 2021 EX-10.6

Amendment #1 to Exclusive License Agreement, dated October 15, 2015, between Arena Pharmaceuticals, Inc. and Connect Biopharm LLC

Exhibit 10.6 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. October 15, 2015 Dr. Zheng Wei Connect Biopharm LLC 4128 Via Candidiz, Suite 145 San Diego CA 92130 Re: Notice of Intention to Cease Prosecution of All Nation

February 26, 2021 EX-3.1

Fourth Amended and Restated Memorandum and Articles of Association, as currently in effect

Exhibit 3.1 THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FOURTH AMENDED AND RESTATED MEMORANDUM AND ARTICLES OF ASSOCIATION OF Connect Biopharma Holdings Limited (adopted by a special resolution passed on December 1, 2020) THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FOURTH AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF Connect

February 26, 2021 F-1

Powers of Attorney (included on signature page to the registration statement)

Table of Contents As filed with the Securities and Exchange Commission on February 26, 2021 Registration No.

February 26, 2021 EX-10.5

Exclusive License Agreement, dated June 19, 2012, between Arena Pharmaceuticals, Inc. and Connect Biopharm LLC

Exhibit 10.5 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. EXCLUSIVE LICENSE AGREEMENT THIS EXCLUSIVE LICENSE AGREEMENT (the ?Agreement?) is entered into as of June 19, 2012 (the ?Effective Date?) by and between ARENA

February 26, 2021 EX-10.11

Employment Agreement, effective as of January 1, 2021, between Connect Biopharm LLC and Zheng Wei, Ph.D.

EX-10.11 12 d295873dex1011.htm EX-10.11 Exhibit 10.11 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is entered into by and between Connect Biopharm LLC (the “Company”) and its affiliates (the “Company Group”), and Dr. Zheng Wei (“Executive”), and shall be effective as of January 1, 2021 (the “Effective Date”). WHEREAS, the Company desires to employ Executive, and Executive desi

February 26, 2021 EX-10.15

Contract of Employment, dated January 20, 2021, between Globalization Partners Limited and Selwyn Ho, MB BS

Exhibit 10.15 CONTRACT OF EMPLOYMENT This statement provides details of the terms and conditions of employment with Globalization Partners Limited (the ?Company?) and Selwyn Ho (?you? or ?your?). In this statement the terms ?Group Companies? means the Company and any holding company or any parent company or any subsidiary or subsidiary undertaking of the Company or such companies, as such terms ar

February 16, 2021 DRS/A

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Table of Contents As confidentially submitted to the Securities and Exchange Commission on February 16, 2021 as Amendment No.

February 16, 2021 DRSLTR

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12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh February 16, 2021 D?sseldorf San Diego VIA EDGAR Ms. Ada D. Sarmento Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission 100 F

January 26, 2021 EX-10.8

[***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed AMENDMENT #3 TO EXCLUS

Exhibit 10.8 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed AMENDMENT #3 TO EXCLUSIVE LICENSE AGREEMENT This Amendment #3 (this ?Amendment?) is entered into as of November 19, 2020 (the ?Amendment Effective Date?), by a

January 26, 2021 EX-10.5

[***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. EXCLUSIVE LICENSE AGR

Exhibit 10.5 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. EXCLUSIVE LICENSE AGREEMENT THIS EXCLUSIVE LICENSE AGREEMENT (the ?Agreement?) is entered into as of June 19, 2012 (the ?Effective Date?) by and between ARENA

January 26, 2021 DRSLTR

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12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES January 26, 2021 VIA EDGAR Ms. Ada D. Sarmento Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission Beijing Boston Brussels Century City Chicago Dubai D?sseldorf Frankfurt Hamburg Hong Kong Houston London Los Angeles Madrid Mila

January 26, 2021 EX-10.6

[***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. October 15, 2015

Exhibit 10.6 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. October 15, 2015 Dr. Zheng Wei Connect Biopharm LLC 4128 Via Candidiz, Suite 145 San Diego CA 92130 Re: Notice of Intention to Cease Prosecution of All Nation

January 26, 2021 DRS/A

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Table of Contents As confidentially submitted to the Securities and Exchange Commission on January 26, 2021 as Amendment No.

January 26, 2021 EX-10.7

[***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. AMENDMENT #2 TO EXCLU

Exhibit 10.7 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. AMENDMENT #2 TO EXCLUSIVE LICENSE AGREEMENT This Amendment #2 (this ?Amendment?) is entered into as of February 23, 2018 (the ?Amendment Effective Date?) by a

December 17, 2020 EX-10.7

House Lease Contract

Exhibit 10.7 House Lease Contract Lessor: Taicang Science and Technology Venture Park Co., Ltd. (hereinafter referred to as ?Party A?) Lessee: Suzhou Connect Biopharmaceuticals, Ltd. (hereinafter referred to as ?Party B?) In accordance with the ? Contract Law of the People?s Republic of China? and relevant provisions, in order to define the rights and obligations of the Lessor and the Lessee, Part

December 17, 2020 DRS

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Table of Contents As confidentially submitted to the Securities and Exchange Commission on December 17, 2020 Registration No.

December 17, 2020 EX-10.6

House Lease Contract

Exhibit 10.6 House Lease Contract Lessor: Taicang Science and Technology Venture Park Co., Ltd. (hereinafter referred to as ?Party A?) Lessee: Suzhou Connect Biopharmaceuticals, Ltd. (hereinafter referred to as ?Party B?) In accordance with the ?Contract Law of the People?s Republic of China? and relevant provisions, in order to define the rights and obligations of the Lessor and the Lessee, Party

December 17, 2020 EX-3.1

THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FOURTH AMENDED AND RESTATED MEMORANDUM AND ARTICLES Connect Biopharma Holdings Limited (adopted by a special resolution passed on December 1, 2020)

Exhibit 3.1 THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FOURTH AMENDED AND RESTATED MEMORANDUM AND ARTICLES OF ASSOCIATION OF Connect Biopharma Holdings Limited (adopted by a special resolution passed on December 1, 2020) THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES FOURTH AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF Connect

December 17, 2020 EX-4.4

SECOND AMENDED AND RESTATED SHAREHOLDERS AGREEMENT

Exhibit 4.4 SECOND AMENDED AND RESTATED SHAREHOLDERS AGREEMENT This SECOND AMENDED AND RESTATED SHAREHOLDERS AGREEMENT (this ?Agreement?) is entered into on December 1, 2020 by and among: 1. Connect Biopharma Holdings Limited, an exempted company incorporated under the laws of the Cayman Islands (the ?Company?); 2. Connect Biopharma Hong Kong Limited, a limited liability company incorporated under

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