| Saham Orang Dalam | 786,266,474 shares |
| Orang Dalam Sejati | 41 |
Skor Sentimen Orang Dalam
Skor Sentimen Orang Dalam mengidentifikasi perusahaan yang dibeli oleh orang dalam korporat.
Ini adalah hasil dari model kuantitatif multifaktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi internal tertinggi. Model penilaian ini menggunakan kombinasi dari jumlah bersih orang dalam yang membeli dalam 90 hari sebelumnya, total saham yang dibeli sebagai persentase dari jumlah saham yang beredar, dan total saham yang dimiliki oleh orang dalam. Angka tersebut berkisar dari 0 hingga 100, dengan angka yang lebih tinggi menunjukkan tingkat akumulasi yang lebih tinggi dibandingkan dengan perusahaan sejenis, dan 50 adalah rata-rata.
Frekuensi Pembaruan: Setiap Hari
Skor Sentimen Petugas
Skor Sentimen Pejabat menemukan perusahaan yang dibeli oleh Pejabat Korporat.
Menurut definisi, Pejabat Korporasi adalah Orang Dalam Korporasi, tetapi tidak seperti beberapa Orang Dalam lainnya (Pemegang Saham 10% dan Anggota Dewan), Pejabat bekerja untuk perusahaan setiap hari, dan mereka menggunakan uang mereka sendiri saat bertransaksi . (Pemegang Saham 10% dan Anggota Dewan seringkali adalah manajer dana yang mengelola uang orang lain.) Dengan demikian, transaksi orang dalam yang dilakukan oleh Pejabat jauh lebih signifikan dan harus ditangani dengan tepat.
Seperti Skor Sentimen Internal, Skor Sentimen Pejabat adalah hasil dari model kuantitatif multi-faktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi pejabat tertinggi.
Frekuensi Pembaruan: Setiap Hari
Metrik Utama Orang Dalam
Kartu ini menunjukkan peringkat perusahaan berdasarkan berbagai metrik internal. Peringkat persentil menunjukkan bagaimana perusahaan ini dibandingkan dengan perusahaan lain di pasar AS. Peringkat yang lebih tinggi menunjukkan situasi yang lebih baik.
Sebagai contoh, secara umum diterima bahwa pembelian oleh orang dalam perusahaan adalah indikator positif, sehingga perusahaan dengan lebih banyak pembelian oleh orang dalam akan mendapat peringkat lebih tinggi daripada perusahaan dengan lebih sedikit pembelian oleh orang dalam (atau bahkan penjualan oleh orang dalam).
Jumlah Bersih Pembelian oleh Orang Dalam (Peringkat)
-4 ( )
10922 out of 11323Jumlah Bersih Pembelian oleh Orang Dalam adalah total jumlah orang dalam yang membeli dikurangi total jumlah orang dalam yang menjual dalam 90 hari terakhir. Peringkat persentil ditunjukkan di sini (kisaran dari 0 hingga 100%).
Persentase Saham yang Dibeli oleh Orang Dalam (Peringkat)
N/A
Persentase Saham yang Dibeli oleh Orang Dalam adalah total jumlah saham yang dibeli oleh orang dalam dikurangi total jumlah saham yang dijual oleh orang dalam dalam 90 hari terakhir, dibagi dengan total jumlah saham yang beredar dan dikalikan dengan 100.
Grafik Perdagangan Orang Dalam
Grafik berikut menunjukkan Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) transaksi orang dalam. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Secara umum, melakukan transaksi di perusahaan mereka berdasarkan informasi material yang belum dipublikasikan adalah ilegal bagi orang dalam. Ini tidak berarti bahwa mereka dilarang melakukan transaksi apa pun di perusahaan mereka sendiri. Namun, mereka wajib melaporkan semua transaksi kepada SEC melalui Formulir 4.
Daftar Orang Dalam dan Metrik Profitabilitas
Tabel ini menampilkan daftar orang dalam yang diketahui, dan dibuat secara otomatis dari pengajuan yang diungkapkan kepada SEC. Selain nama, jabatan terbaru, dan sebutan direktur, pejabat, atau pemilik 10%, kami memberikan kepemilikan terbaru yang diungkapkan. Selain itu, jika memungkinkan, kami memberikan kinerja perdagangan historis untuk orang dalam tersebut. Kinerja perdagangan historis adalah rata-rata tertimbang dari kinerja transaksi pembelian pasar terbuka aktual yang dilakukan oleh orang dalam tersebut. Untuk informasi lebih lanjut tentang bagaimana ini dihitung, tonton webinar YouTube ini.
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| Orang Dalam | Rata-rata Keuntungan (%) | Saham Dimiliki |
Terbagi Disesuaikan |
|---|---|---|---|
| Lawrence M Alleva Director - [D] | 12,600 | 12,600 | |
| Rafael Amado President, R&D - [O] | 17,237 | 17,237 | |
|
M James Barrett
10% Owner -
|
82,978,668 | 82,978,668 | |
|
Peter J Barris
10% Owner -
|
12,000,000 | 12,000,000 | |
|
Forest Baskett
10% Owner -
|
19,500,000 | 19,500,000 | |
| Ali Behbahani Director - [D] | 0 | 0 | |
| William C JR Bertrand Chief Operating Officer - [O] | 986,352 | 986,352 | |
| Gwendolyn Knowlton Binder-Scholl Chief Technology Officer - [O] | 2,487 | 2,487 | |
| Joanna Elizabeth Brewer | 223,512 | ||
| Barbara Gayle Duncan | 144,000 | ||
|
EcoR1 Capital, LLC
10% Owner -
|
100,371,882 | 100,371,882 | |
|
Florence Anthony A. Jr.
10% Owner -
|
19,500,000 | 19,500,000 | |
| John Furey | 196,186 |
| Orang Dalam | Rata-rata Keuntungan (%) | Saham Dimiliki |
Terbagi Disesuaikan |
|---|---|---|---|
| Michael Garone | 0 | ||
| Samuel D Isaly Director - [D] | 6,149,377 | 6,149,377 | |
|
Patrick J Kerins
10% Owner -
|
82,978,668 | 82,978,668 | |
|
Krishna Kittu Kolluri
10% Owner -
|
118,538,000 | 118,538,000 | |
| Giles Francis Bertram Kerr | 124,000 | ||
| Jonathan Kenneth Charles Knowles Director - [D] | 7,208,768 | 7,208,768 | |
| Ian Michael Laing Director - [D] | 58,085,600 | 58,085,600 | |
| John Lunger Chief Patient Supply Officer - [O] | 7,510 | 7,510 | |
|
David M Mott
Director, 10% Owner -
[D]
|
19,500,000 | 19,500,000 | |
| Garry E Menzel Director - [D] | 75,056 | 75,056 | |
|
Nea 14 Gp, Ltd
10% Owner -
|
82,978,668 | 82,978,668 | |
|
NEA Partners 14, L.P.
10% Owner -
|
82,978,668 | 82,978,668 | |
|
New Enterprise Associates 14, L.P.
10% Owner -
|
82,978,668 | 82,978,668 | |
| James Noble Director - [D] | 0 | 0 |
| Orang Dalam | Rata-rata Keuntungan (%) | Saham Dimiliki |
Terbagi Disesuaikan |
|---|---|---|---|
| Elliot Norry Chief Medical Officer - [O] | 7,510 | 7,510 | |
| Orbimed Advisors Llc Director - [D] | 4,901,310 | 4,901,310 | |
| OrbiMed Capital GP V LLC Director - [D] | 4,901,310 | 4,901,310 | |
| Cintia Piccina Chief Commercial Officer - [O] | 18,421 | 18,421 | |
| Adrian Rawcliffe Chief Executive Officer, Director - [D] [O] | 44,327 | 44,327 | |
|
Scott D Sandell
10% Owner -
|
19,500,000 | 19,500,000 | |
| Charles Elliott Sigal Director - [D] | 314,100 | 314,100 | |
|
Sonsini Peter W.
10% Owner -
|
19,500,000 | 19,500,000 | |
| Helen Katrina Tayton-martin Chief Business Officer - [O] | 1,800,000 | 1,800,000 | |
| Thompson Peter A. Director - [D] | 4,901,310 | 4,901,310 | |
|
Ravi Viswanathan
10% Owner -
|
12,000,000 | 12,000,000 | |
|
Harry R Weller
10% Owner -
|
118,538,000 | 118,538,000 | |
| Gavin Wood Chief Financial Officer - [O] | 0 | 0 | |
| Tal Zvi Zaks | 144,000 |
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Rekam Jejak Pembelian Orang Dalam - Analisis Keuntungan Jangka Pendek
Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoretis .
Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.
Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).
Rekam Jejak Penjualan Orang Dalam - Analisis Kerugian Jangka Pendek
Dalam bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan dalam pasar terbuka yang tidak direncanakan oleh orang dalam yang dilakukan di ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoretis .
Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.
Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).
Riwayat Transaksi
Klik ikon tautan untuk melihat riwayat transaksi lengkap. Transaksi yang dilaporkan sebagai bagian dari rencana perdagangan otomatis 10b5-1 akan memiliki tanda X di kolom yang bertanda 10b-5.
| Berkas Tanggal |
Perdagangan Tanggal |
Formulir | Orang Dalam | Ticker | Judul Keamanan | Kode | Langsung | Latihan Harga |
Satuan Harga |
Unit Diubah |
Nilai Diubah (1 ribu) |
Sisa Pilihan |
Sisa Saham |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-09-03 | 2025-09-02 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.0099 | -96,000 | -1 | 0 | ||||
| 2025-08-29 | 2025-08-28 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.0101 | -207,000 | -2 | 986,352 | ||||
| 2025-08-19 | 2025-08-18 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.0120 | -14,671,794 | -176 | 0 | ||||
| 2025-08-19 | 2025-08-15 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.0110 | -4,828,206 | -53 | 14,671,794 | ||||
| 2025-07-30 | 2025-07-30 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0.1021 | -27,433,338 | -2,801 | 100,371,882 | ||||
| 2025-07-30 | 2025-07-29 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0.1012 | -2,687,460 | -272 | 127,805,220 | ||||
| 2025-07-30 | 2025-07-28 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0.1125 | -33,931,740 | -3,817 | 130,492,680 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -5,584 | -3 | 7,510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -5,584 | -3 | 7,510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -5,584 | -3 | 7,510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -30,601 | -18 | 44,327 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -12,991 | -7 | 18,421 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -29,096 | -17 | 41,582 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -17,934 | -11 | 25,711 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -12,539 | -7 | 17,801 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -9,803 | -6 | 13,756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -8,124 | -5 | 11,516 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -4,268 | -3 | 5,845 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -9,803 | -6 | 13,756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -5,471 | -3 | 7,623 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -4,268 | -3 | 5,845 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -9,803 | -6 | 13,756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -5,471 | -3 | 7,623 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -4,268 | -3 | 5,845 | ||||
| 2024-06-18 | 2024-06-18 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9300 | -24,531 | -23 | 38,293 | ||||
| 2024-03-26 | 3 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 164,424,420 | ||||||||
| 2024-01-17 | 2024-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -30,080 | -20 | 44,848 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -9,304 | -7 | 14,104 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -12,967 | -9 | 19,257 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -5,309 | -4 | 7,785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -2,287 | -2 | 3,363 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -12,805 | -9 | 19,015 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -5,309 | -4 | 7,785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -4,681 | -4 | 7,023 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -13,599 | -9 | 20,201 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -5,309 | -4 | 7,785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -4,681 | -4 | 7,023 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -5,220 | -4 | 7,874 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -4,009 | -3 | 6,104 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -17,257 | -15 | 26,388 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -11,945 | -10 | 18,395 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -5,220 | -4 | 7,874 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -4,009 | -3 | 6,104 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -7,799 | -7 | 11,841 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -4,009 | -3 | 6,104 | ||||
| 2023-09-01 | 2023-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7800 | -2,403 | -2 | 3,449 | ||||
| 2023-08-01 | 2023-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9056 | -3,096 | -3 | 4,718 | ||||
| 2023-07-10 | 2023-07-10 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9108 | -47,702 | -43 | 75,056 | ||||
| 2023-06-27 | 2023-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9200 | -2,333 | -2 | 3,519 | ||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | 209,931 | 209,931 | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | 200,647 | 200,647 | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | 200,646 | 200,646 | ||||||
| 2023-01-31 | 2023-01-31 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8696 | -11,890 | -22 | 19,535 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -4,440 | -8 | 7,264 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -10,057 | -19 | 13,351 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -4,440 | -8 | 7,264 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -2,159 | -4 | 3,491 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -4,973 | -8 | 8,121 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -3,843 | -7 | 6,270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -4,973 | -8 | 8,121 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -3,843 | -7 | 6,270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -7,449 | -13 | 12,191 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -3,843 | -7 | 6,270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -18,763 | -32 | 24,882 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -13,042 | -23 | 17,298 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -3,584 | -6 | 5,781 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -5,073 | -9 | 6,631 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -876 | -1 | 1,361 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -1,100 | -2 | 1,725 | ||||
| 2022-09-01 | 2022-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.9689 | -2,536 | -5 | 3,316 | ||||
| 2022-08-01 | 2022-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7735 | -2,983 | -5 | 4,829 | ||||
| 2022-08-01 | 2022-08-01 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7735 | -21,040 | -37 | 34,824 | ||||
| 2022-07-05 | 2022-07-05 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6781 | -1,973 | -3 | 3,104 | ||||
| 2022-06-27 | 2022-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6300 | -2,562 | -4 | 3,290 | ||||
| 2022-05-23 | 2022-05-20 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.2904 | 39,000 | 11 | 96,000 | ||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 223,512 | 223,512 | |||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | 0.30 | 333,792 | 333,792 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 335,184 | 335,184 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 754,200 | 754,200 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0.45 | 3,376,992 | 3,376,992 | |||||
| 2022-01-18 | 2022-01-18 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -4,368 | -14 | 7,336 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -4,368 | -14 | 7,336 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -2,121 | -7 | 3,529 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -11,096 | -35 | 12,312 | ||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -2,248 | -8 | 3,754 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -3,770 | -13 | 6,343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -1,076 | -4 | 1,749 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -3,770 | -13 | 6,343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -854 | -3 | 1,383 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -3,770 | -13 | 6,343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -3,046 | -11 | 3,356 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -14,362 | -51 | 15,978 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 471,360 | 471,360 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 2,110,608 | 2,110,608 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 1,047,480 | 1,047,480 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 4,690,224 | 4,690,224 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-05 | 2022-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -3,490 | -14 | 5,873 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -1,070 | -4 | 1,755 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -849 | -3 | 1,388 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -5,532 | -22 | 6,172 | ||||
| 2021-09-01 | 2021-09-01 | 4 | Rawcliffe Adrian | ADAP] | American Depositary Shares representing Ordinary Shares | D | 5.1950 | -2,782 | -14 | 3,070 | ||||
| 2021-08-02 | 2021-08-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5848 | -2,939 | -11 | 4,873 | ||||
| 2021-07-02 | 2021-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 505,918 | 505,918 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 474,385 | 474,385 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 474,385 | 474,385 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-02 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.2649 | -4,375 | -19 | 7,329 | ||||
| 2021-07-02 | 2021-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 579,494 | 579,494 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.2649 | -1,907 | -8 | 3,170 | ||||
| 2021-06-28 | 2021-06-28 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.3700 | -2,794 | -12 | 3,058 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 0.7900 | 12,600 | 10 | 12,600 | ||||
| 2021-03-03 | 2021-03-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.1570 | 1,785,000 | 280 | 1,800,000 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.6695 | -2,111 | -12 | 3,539 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.6695 | -4,358 | -25 | 7,346 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.6695 | -9,879 | -56 | 13,529 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -2,234 | -14 | 3,768 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -1,058 | -7 | 1,767 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -841 | -5 | 1,396 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -2,707 | -17 | 3,695 | ||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 728,160 | 728,160 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 3,260,400 | 3,260,400 | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -1,065 | -6 | 1,760 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -845 | -5 | 1,392 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -3,499 | -19 | 5,864 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -4,967 | -26 | 6,737 | ||||
| 2020-12-16 | 2020-12-14 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.6896 | 24,000 | 17 | 57,000 | ||||
| 2020-12-15 | 2020-12-14 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.6948 | 207,000 | 144 | 284,808 | ||||
| 2020-09-02 | 2020-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 8.5149 | -2,776 | -24 | 3,076 | ||||
| 2020-08-04 | 2020-08-03 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 9.2500 | -2,788 | -26 | 3,064 | ||||
| 2020-08-04 | 2020-08-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 8.7409 | -200,000 | -1,748 | 0 | ||||
| 2020-08-04 | 2020-08-03 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 9.2500 | -4,823 | -45 | 8,066 | ||||
| 2020-07-01 | 2020-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 184,258 | 184,258 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 196,186 | 196,186 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 197,678 | 197,678 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 144,000 | 144,000 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 144,000 | 144,000 | |||||
| 2020-07-01 | 2020-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 226,753 | 226,753 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 184,258 | 184,258 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 179,785 | 179,785 | |||||
| 2020-06-30 | 2020-06-29 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 1.6200 | 33,000 | 53 | 33,000 | ||||
| 2020-06-11 | 2020-06-09 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.8900 | 12,900 | 24 | 12,900 | ||||
| 2020-06-02 | 2020-05-29 | 4 | Noble James | ADAP | American Depositary Shares | D | 9.3320 | -500,000 | -4,666 | 0 | ||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 565,000 | 565,000 | |||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.45 | 2,500,000 | 2,500,000 | |||||
| 2020-04-01 | 2020-04-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.45 | 31,000 | 31,000 | |||||
| 2020-01-28 | 2020-01-24 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 135,600 | 135,600 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 201,600 | 201,600 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 1,257,744 | 1,257,744 | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 1,257,744 | 1,257,744 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 561,792 | 561,792 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 2,515,536 | 2,515,536 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 1,257,744 | 1,257,744 | |||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | 5.0000 | -200,000 | -1,000 | 0 | ||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | 4.0000 | -100,000 | -400 | 0 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -3,236 | -17 | 3,166 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -1,144 | -6 | 1,681 | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 5.0000 | -50,000 | -250 | 0 | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 4.0000 | -50,000 | -200 | 0 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -2,397 | -12 | 3,605 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -911 | -5 | 1,326 | ||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5,358 | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5,358 | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5,358 | ||||||||
| 2020-01-07 | 2020-01-06 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.2000 | -5,900 | -7 | 5,804 | ||||
| 2020-01-07 | 2020-01-06 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.2000 | -3,731 | -4 | 5,632 | ||||
| 2020-01-07 | 2020-01-06 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.2000 | -1,148 | -1 | 1,677 | ||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 140,448 | 140,448 | |||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.27 | 628,872 | 628,872 | |||||
| 2019-08-07 | 2019-08-06 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | 2.0600 | -11,043 | -23 | 17,237 | ||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57,612 | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57,612 | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57,612 | ||||||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 187,500 | 187,500 | |||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.55 | 839,568 | 839,568 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 234,407 | 234,407 | |||||
| 2019-07-03 | 2019-07-02 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 350,947 | 350,947 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 271,209 | 271,209 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 124,000 | 124,000 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 234,407 | 234,407 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 124,000 | 124,000 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 240,541 | 240,541 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 124,000 | 124,000 | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 140,448 | 140,448 | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.68 | 628,872 | 628,872 | |||||
| 2019-05-17 | 2019-05-16 | 4 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.1430 | 1,773,100 | 254 | 1,773,100 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -3,084 | -17 | 3,318 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -3,028 | -16 | 4,974 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -2,271 | -12 | 3,731 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -1,514 | -8 | 2,487 | ||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 561,792 | 561,792 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 2,515,536 | 2,515,536 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 224,724 | 224,724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,006,224 | 1,006,224 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,257,744 | 1,257,744 | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 224,724 | 224,724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,006,224 | 1,006,224 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 224,724 | 224,724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,006,224 | 1,006,224 | |||||
| 2018-12-19 | 2018-12-17 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 0.8400 | 47,280 | 40 | 47,280 | ||||
| 2018-10-02 | 2018-10-01 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | 13.7900 | -25,000 | -345 | 0 | ||||
| 2018-09-10 | 2018-09-07 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-08-31 | 2018-08-29 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | 10.2500 | -25,000 | -256 | 0 | ||||
| 2018-08-07 | 2018-08-06 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 678,720 | 678,720 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 154,809 | 154,809 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 158,233 | 158,233 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 124,000 | 124,000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 124,000 | 124,000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 124,000 | 124,000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 154,809 | 154,809 | |||||
| 2018-06-26 | 2018-06-22 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 187,330 | 187,330 | |||||
| 2018-06-06 | 2018-06-06 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -1,600 | -22 | 4,901,310 | ||||
| 2018-06-06 | 2018-06-04 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5700 | -17,100 | -232 | 4,902,910 | ||||
| 2018-06-06 | 2018-06-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -1,600 | -22 | 4,901,310 | ||||
| 2018-06-06 | 2018-06-04 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5700 | -17,100 | -232 | 4,902,910 | ||||
| 2018-06-01 | 2018-06-01 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -50,000 | -674 | 4,920,010 | ||||
| 2018-06-01 | 2018-05-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5200 | -121,000 | -1,636 | 4,970,010 | ||||
| 2018-06-01 | 2018-06-01 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -50,000 | -674 | 4,920,010 | ||||
| 2018-06-01 | 2018-05-30 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5200 | -121,000 | -1,636 | 4,970,010 | ||||
| 2018-05-16 | 2018-05-14 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5000 | -10,300 | -139 | 5,091,010 | ||||
| 2018-05-16 | 2018-05-14 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5000 | -10,300 | -139 | 5,091,010 | ||||
| 2018-03-29 | 2018-03-29 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5300 | -31,983 | -369 | 5,101,310 | ||||
| 2018-03-29 | 2018-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5000 | -1,016,084 | -11,685 | 5,133,293 | ||||
| 2018-03-29 | 2018-03-29 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5300 | -31,983 | -369 | 5,101,310 | ||||
| 2018-03-29 | 2018-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5000 | -1,016,084 | -11,685 | 5,133,293 | ||||
| 2018-03-28 | 2018-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-23 | 2018-03-23 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-22 | 2018-03-20 | 4 | Rawcliffe Adrian | ADAP | Ordinary Shares | D | 1.7100 | -600,000 | -1,026 | 0 | ||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 384,120 | 384,120 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 1,719,936 | 1,719,936 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 192,060 | 192,060 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 859,968 | 859,968 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 144,048 | 144,048 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 644,976 | 644,976 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 96,036 | 96,036 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 429,984 | 429,984 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 153,648 | 153,648 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 687,984 | 687,984 | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 153,648 | 153,648 | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 687,984 | 687,984 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 144,000 | 144,000 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 228,765 | 228,765 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 220,788 | 220,788 | |||||
| 2017-07-03 | 2017-07-03 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 302,561 | 302,561 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 243,724 | 243,724 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 144,000 | 144,000 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 220,788 | 220,788 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 223,779 | 223,779 | |||||
| 2017-03-28 | 2017-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 4.2000 | 1,190,476 | 5,000 | 6,149,377 | ||||
| 2017-03-28 | 2017-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 4.2000 | 1,190,476 | 5,000 | 6,149,377 | ||||
| 2017-03-28 | 2017-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-01-18 | 2017-01-13 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2016-12-01 | 2016-11-29 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0.81 | 288,000 | 288,000 | |||||
| 2016-12-01 | 2016-11-29 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.81 | 288,000 | 288,000 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 186,142 | 186,142 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 196,678 | 196,678 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 184,562 | 184,562 | |||||
| 2016-08-12 | 2016-08-11 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 191,410 | 191,410 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Laing Ian Michael | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 144,000 | 144,000 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 184,562 | 184,562 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Knowles Jonathan Kenneth Charles | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 217,222 | 217,222 | |||||
| 2016-05-25 | 2016-05-24 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4800 | 518,400 | 5,433 | 29,753,404 | ||||
| 2016-05-25 | 2016-05-23 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4000 | 1,191,600 | 12,393 | 29,235,004 | ||||
| 2016-05-25 | 2016-05-20 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.0400 | 2,400 | 24 | 28,043,404 | ||||
| 2016-05-25 | 2016-05-24 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4800 | 518,400 | 5,433 | 29,753,404 | ||||
| 2016-05-25 | 2016-05-23 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4000 | 1,191,600 | 12,393 | 29,235,004 | ||||
| 2016-05-25 | 2016-05-20 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.0400 | 2,400 | 24 | 28,043,404 | ||||
| 2016-05-19 | 2016-05-19 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5600 | 15,000 | 23 | 314,100 | ||||
| 2016-05-18 | 2016-05-18 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5500 | 15,000 | 23 | 299,100 | ||||
| 2016-05-18 | 2016-05-17 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5300 | 15,000 | 23 | 284,100 | ||||
| 2016-05-18 | 2016-05-16 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5000 | 15,000 | 22 | 269,100 | ||||
| 2016-01-20 | 2016-01-18 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 939,948 | 939,948 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 704,961 | 704,961 | |||||
| 2016-01-20 | 2016-01-18 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 939,948 | 939,948 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 1,968,016 | 1,968,016 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 939,948 | 939,948 | |||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 561,138 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 561,138 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 359,976 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 359,976 | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 58,085,600 | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 58,085,600 | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 141,168 | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 141,168 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 7,208,768 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 14,205,784 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 7,208,768 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 14,205,784 | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 192,000 | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 192,000 | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 3,630,000 | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 3,630,000 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 21,145,200 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 12,372,600 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 21,145,200 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 12,372,600 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 |
P
Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.
S
Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.
A
Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)
C
Konversi turunan
D
Penjualan atau pengalihan sekuritas kembali ke perusahaan.
F
Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.
G
Pemberian sekuritas oleh atau kepada orang dalam.
K
Swap ekuitas dan transaksi lindung nilai serupa
M
Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)
V
Transaksi yang dilaporkan secara sukarela pada Formulir 4.
J
Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)
