ITRM Insider Trading - Iterum Therapeutics plc

Jumlah Saham Beredar	44,656,906 shares
Saham Orang Dalam	1,602,359 shares
Kepemilikan oleh Orang Dalam	3.59 %
Orang Dalam Sejati	36

Skor Sentimen Orang Dalam

Skor Sentimen Orang Dalam mengidentifikasi perusahaan yang dibeli oleh orang dalam korporat.

Ini adalah hasil dari model kuantitatif multifaktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi internal tertinggi. Model penilaian ini menggunakan kombinasi dari jumlah bersih orang dalam yang membeli dalam 90 hari sebelumnya, total saham yang dibeli sebagai persentase dari jumlah saham yang beredar, dan total saham yang dimiliki oleh orang dalam. Angka tersebut berkisar dari 0 hingga 100, dengan angka yang lebih tinggi menunjukkan tingkat akumulasi yang lebih tinggi dibandingkan dengan perusahaan sejenis, dan 50 adalah rata-rata.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan akumulasi orang dalam tertinggi.

Lihat Saham dengan Peringkat Tertinggi

Skor Sentimen Petugas

Skor Sentimen Pejabat menemukan perusahaan yang dibeli oleh Pejabat Korporat.

Menurut definisi, Pejabat Korporasi adalah Orang Dalam Korporasi, tetapi tidak seperti beberapa Orang Dalam lainnya (Pemegang Saham 10% dan Anggota Dewan), Pejabat bekerja untuk perusahaan setiap hari, dan mereka menggunakan uang mereka sendiri saat bertransaksi . (Pemegang Saham 10% dan Anggota Dewan seringkali adalah manajer dana yang mengelola uang orang lain.) Dengan demikian, transaksi orang dalam yang dilakukan oleh Pejabat jauh lebih signifikan dan harus ditangani dengan tepat.

Seperti Skor Sentimen Internal, Skor Sentimen Pejabat adalah hasil dari model kuantitatif multi-faktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi pejabat tertinggi.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan sentimen orang dalam tertinggi.

Lihat Saham dengan Peringkat Tertinggi

Metrik Utama Orang Dalam

Kartu ini menunjukkan peringkat perusahaan berdasarkan berbagai metrik internal. Peringkat persentil menunjukkan bagaimana perusahaan ini dibandingkan dengan perusahaan lain di pasar AS. Peringkat yang lebih tinggi menunjukkan situasi yang lebih baik.

Sebagai contoh, secara umum diterima bahwa pembelian oleh orang dalam perusahaan adalah indikator positif, sehingga perusahaan dengan lebih banyak pembelian oleh orang dalam akan mendapat peringkat lebih tinggi daripada perusahaan dengan lebih sedikit pembelian oleh orang dalam (atau bahkan penjualan oleh orang dalam).

Jumlah Bersih Pembelian oleh Orang Dalam (Peringkat)

1 ( )

350 out of 11305

Jumlah Bersih Pembelian oleh Orang Dalam adalah total jumlah orang dalam yang membeli dikurangi total jumlah orang dalam yang menjual dalam 90 hari terakhir. Peringkat persentil ditunjukkan di sini (kisaran dari 0 hingga 100%).

Persentase Saham yang Dibeli oleh Orang Dalam (Peringkat)

0.034 %( )

362 out of 11224

Persentase Saham yang Dibeli oleh Orang Dalam adalah total jumlah saham yang dibeli oleh orang dalam dikurangi total jumlah saham yang dijual oleh orang dalam dalam 90 hari terakhir, dibagi dengan total jumlah saham yang beredar dan dikalikan dengan 100.

Grafik Perdagangan Orang Dalam

Grafik berikut menunjukkan Iterum Therapeutics plc transaksi orang dalam. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Secara umum, melakukan transaksi di perusahaan mereka berdasarkan informasi material yang belum dipublikasikan adalah ilegal bagi orang dalam. Ini tidak berarti bahwa mereka dilarang melakukan transaksi apa pun di perusahaan mereka sendiri. Namun, mereka wajib melaporkan semua transaksi kepada SEC melalui Formulir 4.

Daftar Orang Dalam dan Metrik Profitabilitas

Tabel ini menampilkan daftar orang dalam yang diketahui, dan dibuat secara otomatis dari pengajuan yang diungkapkan kepada SEC. Selain nama, jabatan terbaru, dan sebutan direktur, pejabat, atau pemilik 10%, kami memberikan kepemilikan terbaru yang diungkapkan. Selain itu, jika memungkinkan, kami memberikan kinerja perdagangan historis untuk orang dalam tersebut. Kinerja perdagangan historis adalah rata-rata tertimbang dari kinerja transaksi pembelian pasar terbuka aktual yang dilakukan oleh orang dalam tersebut. Untuk informasi lebih lanjut tentang bagaimana ini dihitung, tonton webinar YouTube ini.

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Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Brenton Karl Ahrens Director - [D]	0	0
Canaan X L.p. Director, 10% Owner - [D] [10%]	1,733,170	115,545
Canaan Partners X LLC Director, 10% Owner - [D] [10%]	0	115,545
Mark Chin Director - [D]	18,306	18,306
Alexander J Denner 10% Owner - [10%]	0	0
Dunne Michael W. Director - [D]	235,001	235,001
Paul R Edick Director - [D]	31,390	2,093
Fhm Vii, L.l.c. 10% Owner - [10%]	333,000	22,744
Fhm Vii, L.p. 10% Owner - [10%]	333,000	22,744
Fishman Corey N. Chief Executive Officer, Director - [D] [O]	137,062	137,062
Frazier Healthcare VII, L.P. 10% Owner - [10%]	333,000	22,744
Frazier Healthcare VII-A, L.P. 10% Owner - [10%]	333,000	22,744

Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
James Healy 10% Owner - [10%]	1,226,514	81,768
Ronald Hunt Director - [D]	91,122	91,122
Beth Hecht Director - [D]	18,839	18,839
Patrick J Heron Director - [D]	9,006	600
David George Kelly Director - [D]	37,108	2,474
Peter Kolchinsky 10% Owner - [10%]	11,651,597	776,773
Vijay K Lathi 10% Owner - [10%]	384,615	25,641
Shahzad Malik Director - [D]	838,325	55,888
Matthews Judith M. Chief Financial Officer - [O]	8,135	8,135
Anand Mehra 10% Owner - [10%]	1,726,514	115,101
Michael Powell 10% Owner - [10%]	1,226,514	81,768
Sailaja Puttagunta Chief Medical Officer - [O]	10,369	10,369

Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Ra Capital Management, Llc 10% Owner - [10%]	11,651,597	776,773
RA Capital Healthcare Fund LP 10% Owner - [10%]	11,651,597	776,773
Liam Ratcliffe 10% Owner - [10%]	384,615	25,641
Sarissa Capital Catapult Fund LLC 10% Owner - [10%]	0	0
Sarissa Capital Hawkeye Fund LP 10% Owner - [10%]	0	0
Sarissa Capital Management LP 10% Owner - [10%]	0	0
Sarissa Capital Master Fund II LP 10% Owner - [10%]	0	0
Sarissa Capital Offshore Master Fund LP 10% Owner - [10%]	0	0
Schaffnit Jeffrey R. Chief Commercial Officer - [O]	0	0
Shah Rajeev M. 10% Owner - [10%]	11,651,597	776,773
Sofinnova Management IX, L.L.C. 10% Owner - [10%]	1,226,514	81,768
Sofinnova Venture Partners IX, L.P. 10% Owner - [10%]	1,226,514	81,768

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Rekam Jejak Pembelian Orang Dalam - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di ITRM / Iterum Therapeutics plc. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Maksimal	Harga di Maksimal	Maksimal Keuntungan ($)	Maksimum Pengembalian (%)
2025-08-08	Dunne Michael W.	15,000	0.7236	15,000	0.7236	10,854	10	0.8700	2,196	20.23
2023-12-22	Dunne Michael W.	25,000	1.4000	25,000	1.4000	35,000
2023-12-18	Dunne Michael W.	10,000	1.8442	10,000	1.8442	18,442
2023-11-22	Dunne Michael W.	20,000	2.0345	20,000	2.0345	40,690
2023-11-20	Fishman Corey N.	10,000	1.5863	10,000	1.5863	15,863
2022-09-07	Dunne Michael W.	10,000	2.2200	10,000	2.2200	22,200
2020-10-27	Dunne Michael W.	61,540		4,103
2018-11-30	Kelly David George	10,000	6.2887	667	94.3305	62,887

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

ITRM / Iterum Therapeutics plc Insider Trades

Rekam Jejak Penjualan Orang Dalam - Analisis Kerugian Jangka Pendek

Dalam bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan dalam pasar terbuka yang tidak direncanakan oleh orang dalam yang dilakukan di ITRM / Iterum Therapeutics plc. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Menit	Harga di Menit	Kerugian Maksimal Dihindari ($)	Kerugian Maksimal Dihindari (%)
2022-12-02	Puttagunta Sailaja	3,365	1.3200	3,365	1.3200	4,442	327	0.6494	-2,256	-50.79
2022-09-20	Ahrens Brenton Karl	7,246	1.7817	7,246	1.7817	12,910
2022-09-19	Ahrens Brenton Karl	15,000	1.7652	15,000	1.7652	26,478
2022-09-16	Ahrens Brenton Karl	15,000	1.9028	15,000	1.9028	28,542
2022-09-15	Ahrens Brenton Karl	15,000	2.0181	15,000	2.0181	30,272
2022-09-14	Ahrens Brenton Karl	15,000	2.0971	15,000	2.0971	31,456
2022-09-13	Ahrens Brenton Karl	15,000	2.1412	15,000	2.1412	32,118
2022-09-12	Ahrens Brenton Karl	15,000	2.3072	15,000	2.3072	34,608
2022-09-09	Ahrens Brenton Karl	15,000	2.3153	15,000	2.3153	34,730

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

Riwayat Transaksi

Klik ikon tautan untuk melihat riwayat transaksi lengkap. Transaksi yang dilaporkan sebagai bagian dari rencana perdagangan otomatis 10b5-1 akan memiliki tanda X di kolom yang bertanda 10b-5.

Berkas Tanggal	Perdagangan Tanggal	Formulir	Orang Dalam	Ticker	Judul Keamanan	Kode	Langsung	Latihan Harga	Satuan Harga	Unit Diubah	Nilai Diubah (1 ribu)	Sisa Pilihan	Sisa Saham
2025-08-12	2025-08-08	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		0.7236	15,000	11		235,001
2024-08-12	2024-08-06	4	Fishman Corey N.	ITRM	Ordinary Shares	M - Exercise	D			82,613			137,062
2024-08-12	2024-08-06	4	HUNT RONALD By New Leaf Biopharma Opportunities II, L.P.	ITRM	Ordinary Shares	M - Exercise	I			65,481			91,122
2024-08-12	2024-08-06	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	M - Exercise	I			182,453			253,898
2024-08-12	2024-08-06	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			106,247			220,001
2023-12-27	2023-12-22	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		1.4000	25,000	35		113,754
2023-12-19	2023-12-18	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		1.8442	10,000	18		88,754
2023-12-04	2023-12-01	4	Puttagunta Sailaja	ITRM	Ordinary Shares	F - Taxes	D		2.1200	-2,933	-6		10,369
2023-12-04	2023-12-01	4	Puttagunta Sailaja	ITRM	Ordinary Shares	A - Award	D			8,333			13,302
2023-11-27	2023-11-22	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		2.0345	20,000	41		78,754
2023-11-20	2023-11-20	4	Fishman Corey N.	ITRM	Ordinary Shares	P - Purchase	D		1.5863	10,000	16		54,449
2023-10-02	2023-10-01	4	HUNT RONALD	ITRM	Ordinary Shares	M - Exercise	D			5,479			14,346
2023-10-02	2023-10-01	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			3,487			58,754
2023-07-03	2023-07-01	4	HUNT RONALD	ITRM	Ordinary Shares	M - Exercise	D			2,796			8,867
2023-07-03	2023-07-01	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			1,779			55,267
2023-06-15	2023-06-15	4	Hecht Beth	ITRM	Ordinary Shares	M - Exercise	D			15,853			18,839
2023-06-15	2023-06-15	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			15,853			53,488
2023-06-15	2023-06-15	4	Chin Mark	ITRM	Ordinary Shares	M - Exercise	D			15,853			18,306
2023-06-05	2023-04-01	4/A	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			1,299			37,635
2023-04-03	2023-04-01	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			1,299			37,636
2023-04-03	2023-04-01	4	HUNT RONALD	ITRM	Ordinary Shares	M - Exercise	D			2,041			6,071
2023-03-14	2023-03-11	4	Matthews Judith M.	ITRM	Ordinary Shares	F - Taxes	D		0.9600	-2,883	-3		8,135
2023-03-14	2023-03-11	4	Matthews Judith M.	ITRM	Ordinary Shares	A - Award	D			6,666			11,018
2023-03-14	2023-03-11	4	Fishman Corey N.	ITRM	Ordinary Shares	F - Taxes	D		0.9600	-5,683	-5		44,449
2023-03-14	2023-03-11	4	Fishman Corey N.	ITRM	Ordinary Shares	A - Award	D			14,333			50,132
2023-01-04	2023-01-01	4	HUNT RONALD	ITRM	Ordinary Shares	M - Exercise	D			1,197			4,030
2023-01-04	2023-01-01	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			761			36,337
2022-12-05	2022-12-02	4	Puttagunta Sailaja	ITRM	Ordinary Shares	S - Sale	D		1.3200	-3,365	-4		4,969
2022-12-05	2022-12-01	4	Puttagunta Sailaja	ITRM	Ordinary Shares	A - Award	D			8,334			8,334
2022-09-20	2022-09-20	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		1.7817	-7,246	-13		0
2022-09-20	2022-09-19	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		1.7652	-15,000	-26		7,246
2022-09-20	2022-09-16	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		1.9028	-15,000	-29		22,246
2022-09-15	2022-09-15	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		2.0181	-15,000	-30		37,246
2022-09-15	2022-09-14	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		2.0971	-15,000	-31		52,246
2022-09-15	2022-09-13	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		2.1412	-15,000	-32		67,246
2022-09-12	2022-09-12	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		2.3072	-15,000	-35		82,246
2022-09-12	2022-09-09	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		2.3153	-15,000	-35		97,246
2022-09-12	2022-09-08	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	S - Sale	I		2.2635	-3,298	-7		112,246
2022-09-09	2022-09-07	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		2.2200	10,000	22		35,576
2022-06-24	2022-06-23	4	Hecht Beth	ITRM	Ordinary Shares	M - Exercise	D			36,798			44,805
2022-06-24	2022-06-23	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			36,798			383,647
2022-06-24	2022-06-23	4	Chin Mark	ITRM	Ordinary Shares	M - Exercise	D			36,798			36,798
2022-06-24	2022-06-23	4	HUNT RONALD	ITRM	Ordinary Shares	M - Exercise	D			36,798			42,501
2022-03-29	2022-03-25	4	Dunne Michael W.	ITRM	Restricted Share Units	A - Award	D			11,426		11,426
2022-03-29	2022-03-25	4	Dunne Michael W.	ITRM	Restricted Share Units	M - Exercise	D			-10,494		0
2022-03-29	2022-03-25	4	Dunne Michael W.	ITRM	Ordinary Shares	M - Exercise	D			10,494			346,849
2022-03-29	2022-03-25	4	Ahrens Brenton Karl	ITRM	Stock Option (Right to Buy)	A - Award	D	0.45		47,436		47,436
2022-03-29	2022-03-25	4	HUNT RONALD	ITRM	Restricted Share Units	A - Award	D			17,955		17,955
2022-03-22	2022-03-18	4	Hecht Beth	ITRM	Restricted Share Units	M - Exercise	D			-7,642		0
2022-03-22	2022-03-18	4	Hecht Beth	ITRM	Ordinary Shares	M - Exercise	D			7,642			8,007
2022-03-15	2022-03-14	4/A	Matthews Judith M.	ITRM	Ordinary Shares	S - Sale	D		0.3100	-63,340	-20		65,292
2022-03-15	2022-03-14	4	Matthews Judith M.	ITRM	Ordinary Shares	S - Sale	D		0.3800	-47,132	-18		81,500
2022-03-15	2022-03-11	4	Matthews Judith M.	ITRM	Restricted Share Units	M - Exercise	D			-100,000		100,000
2022-03-15	2022-03-11	4	Matthews Judith M.	ITRM	Ordinary Shares	A - Award	D			100,000			128,632
2022-03-15	2022-03-11	4	Fishman Corey N.	ITRM	Restricted Share Units	M - Exercise	D			-215,000		215,000
2022-03-15	2022-03-11	4	Fishman Corey N.	ITRM	Ordinary Shares	M - Exercise	D			215,000			537,008
2021-12-14	2021-12-10	4	Puttagunta Sailaja	ITRM	Restricted Share Units	A - Award	D			500,000		500,000
2021-12-14	2021-12-10	4	Puttagunta Sailaja	ITRM	Share Option (Right to Buy)	A - Award	D	0.48		1,800,000		1,800,000
2021-07-27	2021-07-25	4	Dunne Michael W.	ITRM	Ordinary Shares	A - Award	D			80,000			336,355
2021-06-25	2021-06-23	4	Kelly David George	ITRM	Stock Option (Right to Buy)	A - Award	D	2.01		64,706		64,706
2021-06-25	2021-06-23	4	Chin Mark	ITRM	Restricted Stock Units	A - Award	D			36,798		36,798
2021-06-25	2021-06-23	4	Matthews Judith M.	ITRM	Stock Option (Right to Buy)	A - Award	D	2.01		1,936,000		1,936,000
2021-06-25	2021-06-23	4	Hecht Beth	ITRM	Restricted Stock Units	A - Award	D			36,798		36,798
2021-06-25	2021-06-23	4	HUNT RONALD	ITRM	Restricted Stock Units	A - Award	D			36,798		36,798
2021-06-25	2021-06-23	4	Dunne Michael W.	ITRM	Restricted Stock Units	A - Award	D			36,798		36,798
2021-06-25	2021-06-23	4	Ahrens Brenton Karl	ITRM	Stock Option (Right to Buy)	A - Award	D	2.01		64,706		64,706
2021-06-25	2021-06-23	4	Fishman Corey N.	ITRM	Stock Option (Right to Buy)	A - Award	D	2.01		5,280,000		5,280,000
2021-04-21		3	Hecht Beth	ITRM	Ordinary Shares		D						365
2021-03-29	2021-03-25	4	Dunne Michael W.	ITRM	Restricted Stock Units	A - Award	D			10,494		10,494
2021-03-19	2021-03-18	4	Hecht Beth	ITRM	Restricted Stock Units	A - Award	D			7,642		7,642
2021-03-15	2021-03-11	4	Fishman Corey N.	ITRM	Restricted Share Units	A - Award	D			430,000		430,000
2021-03-15	2021-03-11	4	Matthews Judith M.	ITRM	Restricted Share Units	A - Award	D			200,000		200,000
2021-03-03	2020-07-28	4	Chin Mark	ITRM	Ordinary Shares	J - Other	D			-11,857			0
2021-02-12	2021-02-12	4	DENNER ALEXANDER J See footnotes	ITRM	Ordinary Shares	S - Sale	I		2.2700	-10,619,949	-24,107		0
2021-02-12	2021-02-11	4	DENNER ALEXANDER J See Footnotes	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	C - Conversion	I			-15,000,000		0
2021-02-12	2021-02-11	4	DENNER ALEXANDER J See footnotes	ITRM	Ordinary Shares	S - Sale	I		2.5900	-10,000,000	-25,900		10,619,949
2021-02-12	2021-02-11	4	DENNER ALEXANDER J See footnotes	ITRM	Ordinary Shares	C - Conversion	I			20,619,949			20,616,949
2021-02-08	2021-02-04	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	C - Conversion	I			-8,486,000		0
2021-02-08	2021-02-04	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	ITRM	Ordinary Shares	C - Conversion	I			11,651,597			11,651,597
2021-01-27	2021-01-26	4	Fishman Corey N.	ITRM	Ordinary Shares	S - Sale	D		1.7300	-85,445	-148		322,008
2021-01-27	2021-01-25	4	Fishman Corey N.	ITRM	Ordinary Shares	A - Award	D			167,500			407,453
2021-01-27	2021-01-26	4	Matthews Judith M.	ITRM	Ordinary Shares	S - Sale	D		1.7300	-33,868	-59		28,632
2021-01-27	2021-01-25	4	Matthews Judith M.	ITRM	Ordinary Shares	A - Award	D			62,500			62,500
2021-01-27	2021-01-26	4	Dunne Michael W.	ITRM	Ordinary Shares	S - Sale	D		1.7300	-33,143	-57		256,355
2021-01-27	2021-01-25	4	Dunne Michael W.	ITRM	Ordinary Shares	A - Award	D			80,000			289,498
2020-10-28	2020-10-27	4	Dunne Michael W.	ITRM	Warrants (right to buy)	P - Purchase	D	0.65		46,155		46,155
2020-10-28	2020-10-27	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D			61,540			209,498
2020-10-02	2020-09-30	4	Matthews Judith M.	ITRM	Ordinary Shares	S - Sale	D		1.6400	-56,130	-92		0
2020-07-06	2020-07-01	4	Heron Patrick J	ITRM	Restricted Stock Units	M - Exercise	D			-2,852		0
2020-07-06	2020-07-01	4	Heron Patrick J	ITRM	Ordinary Shares	M - Exercise	D			2,852			9,006
2020-07-02	2020-07-01	4	HUNT RONALD	ITRM	Restricted Stock Units	M - Exercise	D			-5,703		0
2020-07-02	2020-07-01	4	HUNT RONALD	ITRM	Ordinary Shares	M - Exercise	D			5,703			5,703
2020-07-02	2020-07-01	4	Chin Mark	ITRM	Restricted Stock Units	M - Exercise	D			-5,703		0
2020-07-02	2020-07-01	4	Chin Mark	ITRM	Ordinary Shares	M - Exercise	D			5,703			11,857
2020-06-16	2020-06-13	4	Kelly David George	ITRM	Restricted Stock Units	M - Exercise	D			-11,406		0
2020-06-16	2020-06-13	4	Kelly David George	ITRM	Ordinary Shares	M - Exercise	D			11,406			37,108
2020-06-12	2020-06-10	4	Kelly David George	ITRM	Stock Option (Right to Buy)	A - Award	D	1.68		62,840		62,840
2020-06-03	2020-06-02	4	Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	S - Sale	D		1.6074	-400,000	-643		1,226,514
2020-06-03	2020-06-01	4	Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	S - Sale	D		1.6912	-100,000	-169		1,626,514
2020-04-09	2020-04-07	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	J - Other	I					0
2020-04-09	2020-04-07	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Ordinary Shares	J - Other	I			-1,089,903			0
2020-01-23	2020-01-21	4	Sofinnova Venture Partners IX, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	D		1,750,000.0000
2020-01-23	2020-01-21	4	CANAAN X L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	D		2,000,000.0000
2020-01-23	2020-01-21	4	Frazier Healthcare VII, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	D		333,000.0000	333,000	110,889,000	333,000
2020-01-23	2020-01-21	4	Frazier Healthcare VII, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	D		1,167,000.0000	1,167,000	1,361,889,000	1,167,000
2020-01-23	2020-01-21	4	Malik Shahzad By Advent Life Science Fund II LP.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		1,495,000.0000
2020-01-23	2020-01-21	4	Malik Shahzad By Advent Life Sciences LLP	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		53,000.0000
2020-01-23	2020-01-21	4	HUNT RONALD By New Leaf Biopharma Opportunities II, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		792,000.0000
2020-01-23	2020-01-21	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		2,208,000.0000
2020-01-23	2020-01-21	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		1,750,000.0000
2020-01-23	2020-01-21	4	Ahrens Brenton Karl By Canaan X L.P	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		2,000,000.0000
2020-01-23	2020-01-21	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		1,900,000.0000
2020-01-23	2020-01-21	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		333,000.0000
2020-01-23	2020-01-21	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	6.500% Exchangeable Senior Subordinated Note due 2025	A - Award	I		1,167,000.0000
2019-06-17	2019-06-13	4	HEALY JAMES	ITRM	Restricted Stock Units	A - Award	D			-5,703		5,703
2019-06-17	2019-06-13	4	Chin Mark	ITRM	Restricted Stock Units	A - Award	D			5,703		5,703
2019-06-17	2019-06-13	4	Heron Patrick J	ITRM	Restricted Stock Units	A - Award	D			2,852		2,852
2019-06-17	2019-06-13	4	Heron Patrick J	ITRM	Stock Option (Right to Buy)	A - Award	D	6.74		9,836		9,836
2019-06-17	2019-06-13	4	Malik Shahzad	ITRM	Stock Option (Right to Buy)	A - Award	D	6.74		19,671		19,671
2019-06-17	2019-06-13	4	HUNT RONALD	ITRM	Restricted Stock Units	A - Award	D			5,703		5,703
2019-06-17	2019-06-13	4	Ahrens Brenton Karl	ITRM	Stock Option (Right to Buy)	A - Award	D	6.74		19,671		19,671
2019-06-17	2019-06-13	4	Kelly David George	ITRM	Restricted Stock Units	A - Award	D			11,406		11,406
2019-05-29	2019-05-24	4	Kelly David George	ITRM	Restricted Stock Units	M - Exercise	D			-6,154		0
2019-05-29	2019-05-24	4	Kelly David George	ITRM	Ordinary Shares	M - Exercise	D			6,154			25,702
2019-05-29	2019-05-24	4	Ahrens Brenton Karl	ITRM	Restricted Stock Units	M - Exercise	D			-6,154		0
2019-05-29	2019-05-24	4	Ahrens Brenton Karl	ITRM	Ordinary Shares	M - Exercise	D			6,154			6,154
2019-05-29	2019-05-24	4	Heron Patrick J	ITRM	Restricted Stock Units	M - Exercise	D			-6,154		0
2019-05-29	2019-05-24	4	Heron Patrick J	ITRM	Ordinary Shares	M - Exercise	D			6,154			6,154
2019-05-29	2019-05-24	4	Chin Mark	ITRM	Restricted Stock Units	M - Exercise	D			-6,154		0
2019-05-29	2019-05-24	4	Chin Mark	ITRM	Ordinary Shares	M - Exercise	D			6,154			6,154
2019-05-29	2019-05-24	4	HEALY JAMES	ITRM	Restricted Stock Units	M - Exercise	D			-6,154		0
2019-05-29	2019-05-24	4	HEALY JAMES	ITRM	Ordinary Shares	M - Exercise	D			6,154			6,154
2019-05-29	2019-05-24	4	Edick Paul R	ITRM	Restricted Stock Units	M - Exercise	D			-6,154		0
2019-05-29	2019-05-24	4	Edick Paul R	ITRM	Ordinary Shares	M - Exercise	D			6,154			31,390
2019-02-19	2019-02-15	4	Dunne Michael W.	ITRM	Stock Option (Right to Buy)	A - Award	D	5.80		85,000		85,000
2019-02-19	2019-02-15	4	Fishman Corey N.	ITRM	Stock Option (Right to Buy)	A - Award	D	5.80		150,000		150,000
2019-02-19	2019-02-15	4	Matthews Judith M.	ITRM	Stock Option (Right to Buy)	A - Award	D	5.80		30,000		30,000
2018-12-04	2018-11-30	4	Kelly David George	ITRM	Ordinary Shares	P - Purchase	D		6.2887	10,000	63		19,548
2018-11-01	2018-10-30	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Ordinary Shares	P - Purchase	I		6.1000	58,000	354		1,089,903
2018-09-06	2018-09-04	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		10.0000	500	5		147,958
2018-08-28	2018-08-27	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		10.0000	500	5		147,458
2018-08-28	2018-08-24	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		10.0000	500	5		146,958
2018-08-27	2018-08-23	4	Edick Paul R	ITRM	Ordinary Shares	P - Purchase	D		10.4374	500	5		25,236
2018-08-21	2018-08-17	4	Fishman Corey N.	ITRM	Ordinary Shares	P - Purchase	D		8.7328	2,000	17		239,953
2018-06-01	2018-05-30	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-248,721		0
2018-06-01	2018-05-30	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-445,576		0
2018-06-01	2018-05-30	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	337,606	4,389		1,031,903
2018-06-01	2018-05-30	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Ordinary Shares	C - Conversion	I			248,721			694,297
2018-06-01	2018-05-30	4	Chin Mark By Arix Bioscience Holdings Ltd.	ITRM	Ordinary Shares	C - Conversion	I			445,576			445,576
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-148,603		0
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-178,230		0
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Series A Preferred Shares	C - Conversion	I			-466,793		0
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Biopharma Opportunities II, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	384,615	5,000		384,615
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	278,062	3,615		1,071,688
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	C - Conversion	I			148,603			793,626
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	C - Conversion	I			178,230			645,023
2018-05-31	2018-05-30	4	HUNT RONALD By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	C - Conversion	I			466,793			466,793
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-148,603		0
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-178,230		0
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Series A Preferred Shares	C - Conversion	I			-466,793		0
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Biopharma Opportunities II, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	384,615	5,000		384,615
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	278,062	3,615		1,071,688
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	C - Conversion	I			148,603			793,626
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	C - Conversion	I			178,230			645,023
2018-05-31	2018-05-30	4	Lathi Vijay K By New Leaf Ventures III, L.P.	ITRM	Ordinary Shares	C - Conversion	I			466,793			466,793
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	D			-229,660		0
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	D			-275,446		0
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Series A Preferred Shares	C - Conversion	D			-721,408		0
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	P - Purchase	D		13.0000	500,000	6,500		1,726,514
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	C - Conversion	D			229,660			1,226,514
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	C - Conversion	D			275,446			996,854
2018-05-30	2018-05-30	4	Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	C - Conversion	D			721,408			721,408
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Series B-2 Preferred Shares	C - Conversion	D			-1,591		0
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Series B-1 Preferred Shares	C - Conversion	D			-4,050		0
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Series A Preferred Shares	C - Conversion	D			-33,259		0
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Ordinary Shares	P - Purchase	D		13.0000	3,000	39		237,953
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Ordinary Shares	C - Conversion	D			1,591			234,953
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Ordinary Shares	C - Conversion	D			4,050			233,362
2018-05-30	2018-05-30	4	Fishman Corey N.	ITRM	Ordinary Shares	C - Conversion	D			33,259			229,312
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Series B-2 Preferred Shares	C - Conversion	D			-2,917		0
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Series B-1 Preferred Shares	C - Conversion	D			-4,050		0
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Series A Preferred Shares	C - Conversion	D			-12,730		0
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Ordinary Shares	P - Purchase	D		13.0000	2,000	26		146,458
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Ordinary Shares	C - Conversion	D			2,917			144,458
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Ordinary Shares	C - Conversion	D			4,050			141,541
2018-05-30	2018-05-30	4	Dunne Michael W.	ITRM	Ordinary Shares	C - Conversion	D			12,730			137,491
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Series B-2 Preferred Shares	C - Conversion	D			-2,466		0
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Series B-1 Preferred Shares	C - Conversion	D			-3,038		0
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Series A Preferred Shares	C - Conversion	D			-10,980		0
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Ordinary Shares	P - Purchase	D		13.0000	4,000	52		56,130
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Ordinary Shares	C - Conversion	D			2,466			52,130
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Ordinary Shares	C - Conversion	D			3,038			49,664
2018-05-30	2018-05-30	4	Matthews Judith M.	ITRM	Ordinary Shares	C - Conversion	D			10,980			46,626
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-44,940		0
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-53,899		0
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Series A Preferred Shares	C - Conversion	I			-141,166		0
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-157,701		0
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-189,141		0
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Series A Preferred Shares	C - Conversion	I			-495,370		0
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	101,150	1,315		341,155
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Ordinary Shares	C - Conversion	I			44,940			240,005
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Ordinary Shares	C - Conversion	I			53,899			195,065
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII-A, L.P.	ITRM	Ordinary Shares	C - Conversion	I			141,166			141,166
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	354,949	4,614		1,197,161
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Ordinary Shares	C - Conversion	I			157,701			842,212
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Ordinary Shares	C - Conversion	I			189,141			684,511
2018-05-30	2018-05-30	4	Heron Patrick J By Frazier Healthcare VII, L.P.	ITRM	Ordinary Shares	C - Conversion	I			495,370			495,370
2018-05-30	2018-05-30	4	Kelly David George	ITRM	Series A Preferred Shares	C - Conversion	D			-9,548		0
2018-05-30	2018-05-30	4	Kelly David George	ITRM	Ordinary Shares	C - Conversion	D			9,548			9,548
2018-05-30	2018-05-30	4	Edick Paul R	ITRM	Series B-2 Preferred Shares	C - Conversion	D			-1,591		0
2018-05-30	2018-05-30	4	Edick Paul R	ITRM	Series B-1 Preferred Shares	C - Conversion	D			-4,050		0
2018-05-30	2018-05-30	4	Edick Paul R	ITRM	Series A Preferred Shares	C - Conversion	D			-15,913		0
2018-05-30	2018-05-30	4	Edick Paul R	ITRM	Ordinary Shares	C - Conversion	D			1,591			24,736
2018-05-30	2018-05-30	4	Edick Paul R	ITRM	Ordinary Shares	C - Conversion	D			4,050			23,145
2018-05-30	2018-05-30	4	Edick Paul R	ITRM	Ordinary Shares	C - Conversion	D			15,913			19,095
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	D			-229,660		0
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	D			-275,446		0
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Series A Preferred Shares	C - Conversion	D			-721,408		0
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Ordinary Shares	P - Purchase	D		13.0000	506,656	6,587		1,733,170
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Ordinary Shares	C - Conversion	D			229,660			1,226,514
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Ordinary Shares	C - Conversion	D			275,446			996,854
2018-05-30	2018-05-30	4	CANAAN X L.P.	ITRM	Ordinary Shares	C - Conversion	D			721,408			721,408
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-229,660		0
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-275,446		0
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Series A Preferred Shares	C - Conversion	I			-721,408		0
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	506,656	6,587		1,733,170
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Ordinary Shares	C - Conversion	I			229,660			1,226,514
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Ordinary Shares	C - Conversion	I			275,446			996,854
2018-05-30	2018-05-30	4	Ahrens Brenton Karl By Canaan X, L.P.	ITRM	Ordinary Shares	C - Conversion	I			721,408			721,408
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences Fund II LP	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-218,338		0
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences Fund II LP	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-391,147		0
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences LLP	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-7,771		0
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences LLP	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-13,921		0
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences Fund II LP	ITRM	Ordinary Shares	P - Purchase	I		13.0000	228,840	2,975		838,325
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences Fund II LP	ITRM	Ordinary Shares	C - Conversion	I			218,338			609,485
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences Fund II LP	ITRM	Ordinary Shares	C - Conversion	I			391,147			391,147
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences LLP	ITRM	Ordinary Shares	P - Purchase	I		13.0000	8,144	106		29,836
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences LLP	ITRM	Ordinary Shares	C - Conversion	I			7,771			21,692
2018-05-30	2018-05-30	4	Malik Shahzad By Advent Life Sciences LLP	ITRM	Ordinary Shares	C - Conversion	I			13,921			13,921
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Series B-2 Preferred Shares	C - Conversion	I			-229,660		0
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Series B-1 Preferred Shares	C - Conversion	I			-275,446		0
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Series A Preferred Shares	C - Conversion	I			-721,408		0
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	P - Purchase	I		13.0000	500,000	6,500		1,726,514
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	C - Conversion	I			229,660			1,226,514
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	C - Conversion	I			275,446			996,854
2018-05-30	2018-05-30	4	HEALY JAMES By Sofinnova Venture Partners IX, L.P.	ITRM	Ordinary Shares	C - Conversion	I			721,408			721,408
2018-05-29	2018-05-24	4	Chin Mark	ITRM	Restricted Stock Units	A - Award	D			6,154		6,154
2018-05-29	2018-05-24	4	Edick Paul R	ITRM	Restricted Stock Units	A - Award	D			6,154		6,154
2018-05-29	2018-05-24	4	Schaffnit Jeffrey R.	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		6,365		6,365
2018-05-29	2018-05-24	4	Schaffnit Jeffrey R.	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		25,461		25,461
2018-05-29	2018-05-24	4	HUNT RONALD	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		11,241		11,241
2018-05-29	2018-05-24	4	Matthews Judith M.	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		23,870		23,870
2018-05-29	2018-05-24	4	Fishman Corey N.	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		127,307		127,307
2018-05-29	2018-05-24	4	Ahrens Brenton Karl	ITRM	Restricted Stock Units	A - Award	D			6,154		6,154
2018-05-29	2018-05-24	4	HEALY JAMES	ITRM	Restricted Stock Units	A - Award	D			6,154		6,154
2018-05-29	2018-05-24	4	Dunne Michael W.	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		79,567		79,567
2018-05-29	2018-05-24	4	Malik Shahzad	ITRM	Stock Option (Right to Buy)	A - Award	D	13.00		11,241		11,241
2018-05-29	2018-05-24	4	Kelly David George	ITRM	Restricted Stock Units	A - Award	D			6,154		6,154
2018-05-29	2018-05-24	4	Heron Patrick J	ITRM	Restricted Stock Units	A - Award	D			6,154		6,154
2018-05-24		3	Fishman Corey N.	ITRM	Ordinary Shares		D						392,106
2018-05-24		3	Fishman Corey N.	ITRM	Ordinary Shares		D						392,106
2018-05-24		3	Fishman Corey N.	ITRM	Ordinary Shares		D						392,106
2018-05-24		3	Dunne Michael W.	ITRM	Ordinary Shares		D						249,522
2018-05-24		3	Dunne Michael W.	ITRM	Ordinary Shares		D						249,522
2018-05-24		3	Dunne Michael W.	ITRM	Ordinary Shares		D						249,522
2018-05-24		3	Matthews Judith M.	ITRM	Ordinary Shares		D						71,292
2018-05-24		3	Matthews Judith M.	ITRM	Ordinary Shares		D						71,292
2018-05-24		3	Matthews Judith M.	ITRM	Ordinary Shares		D						71,292
2018-05-24		3	Schaffnit Jeffrey R.	ITRM	No securities are beneficially owned.		D						0
2018-05-24		3	Edick Paul R	ITRM	Ordinary Shares		D						6,364
2018-05-24		3	Edick Paul R	ITRM	Ordinary Shares		D						6,364
2018-05-24		3	Edick Paul R	ITRM	Ordinary Shares		D						6,364

Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.

Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.

Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)

Konversi turunan

Penjualan atau pengalihan sekuritas kembali ke perusahaan.

Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.

Pemberian sekuritas oleh atau kepada orang dalam.

Swap ekuitas dan transaksi lindung nilai serupa

Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)

Transaksi yang dilaporkan secara sukarela pada Formulir 4.

Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)

ITRM / Iterum Therapeutics plc - Insider Trading and Ownership Report - SEC Form 3, 4, 5