ANAB / AnaptysBio, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

AnaptysBio, Inc.
US ˙ NasdaqGS ˙ US0327241065

Mga Batayang Estadistika
LEI 529900HH4WQT03IG1A12
CIK 1370053
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to AnaptysBio, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 6, 2025 S-8

As filed with the Securities and Exchange Commission on August 6, 2025

As filed with the Securities and Exchange Commission on August 6, 2025 Registration No.

August 6, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 6, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 6, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

August 6, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2025 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (E

August 6, 2025 EX-99.1

Anaptys Announces Second Quarter 2025 Financial Results and Provides Business Update

Anaptys Announces Second Quarter 2025 Financial Results and Provides Business Update •Announces positive data for rosnilimab, a pathogenic T cell depleter, through Week 38 from Phase 2b rheumatoid arthritis trial •Enrollment completed for rosnilimab Phase 2 ulcerative colitis trial; Top-line data through Week 12 on track for Q4 2025 •Ongoing Phase 1 trials in healthy volunteers for ANB033, a CD122

August 6, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) AnaptysBio, Inc.

June 17, 2025 EX-10.1

Amended and Restated 2017 Equity Incentive Plan

anab-ar2017eipasadopted 1 ANAPTYSBIO, INC. AMENDED AND RESTATED 2017 EQUITY INCENTIVE PLAN (AS AMENDED AND RESTATED JUNE 17, 2025) 1. PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible persons whose present and potential contributions are important to the success of the Company, and any Parents and Subsidiaries that exist now or in the future, by of

June 17, 2025 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 17, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

June 3, 2025 EX-99.3

June 2025 Corporate Overview This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not l

anaptyscorporatepresenta June 2025 Corporate Overview This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from the Company’s clinical trials, including rosnilimab’s Phase 2b clinical tri

June 3, 2025 EX-99.1

Anaptys Announces Positive Rosnilimab Data Updated Through Six Months in Robust Phase 2b Trial in RA  Best-in-disease profile with JAK-like efficacy and monthly (Q4W) dosing in both three-month placebo- controlled and six-month blinded treatment per

Anaptys Announces Positive Rosnilimab Data Updated Through Six Months in Robust Phase 2b Trial in RA  Best-in-disease profile with JAK-like efficacy and monthly (Q4W) dosing in both three-month placebo- controlled and six-month blinded treatment period  Favorable safety and tolerability, particularly when compared to standard of care biologics or JAKs  Max response rates have not yet been observed; strict continuation criteria at three months in this Phase 2b trial excluded many patients who either achieved or were trending toward LDA and ACR50  Durable responses for at least two months off drug, with potential for extended dosing intervals (e.

June 3, 2025 EX-99.2

Rosnilimab: Updated Phase 2b Data in RA June 3, 2025 This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 19

rosnilimabpd-1depleteran Rosnilimab: Updated Phase 2b Data in RA June 3, 2025 This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from the Company’s clinical trials, including rosnilimab

June 3, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 3, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 3, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

May 5, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2025 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (

May 5, 2025 EX-10.22

Exclusive License Agreement, dated January 31, 2025, by and between the Company and Vanda Pharmaceuticals Inc.

vandalicenseagreement-re CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT ANAPTYSBIO, INC.

May 5, 2025 EX-99.1

Anaptys Announces First Quarter 2025 Financial Results and Provides Business Update

Anaptys Announces First Quarter 2025 Financial Results and Provides Business Update •Announced rosnilimab, a depleter and agonist targeting PD-1+ T cells, achieved positive results in Phase 2b rheumatoid arthritis (RA) trial; to present updated clinical and translational data in the first week of June •Initial Phase 2 data for rosnilimab in ulcerative colitis (UC) on track for Q4 2025 •Ongoing Phase 1a trials in healthy volunteers for ANB033, a CD122 antagonist, and ANB101, a BDCA2 modulator •Authorized a $75 million Stock Repurchase Program in March 2025 and reiterating cash runway through year-end 2027 SAN DIEGO, May 5, 2025 — AnaptysBio, Inc.

May 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 5, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 5, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number) (

April 29, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a Party other than the Registrant ☐ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

April 29, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Ru

March 24, 2025 EX-99.1

Anaptys Announces Stock Repurchase Plan

Anaptys Announces Stock Repurchase Plan SAN DIEGO, March 24, 2025 — AnaptysBio, Inc.

March 24, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 24, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

February 27, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number: 001-37985 ANAPTYSBIO, INC. (Exact n

February 27, 2025 EX-19.1

Insider Trading Policy

Insider Trading Policy (as amended December 2, 2024) I. Purpose It is illegal for any employee, officer or director of AnaptysBio, Inc. (collectively with its subsidiaries, the “Company”), to trade in the securities of the Company while in the possession of material nonpublic information about the Company. It is also illegal for any employee, officer or director of the Company to give material non

February 27, 2025 EX-99.1

Anaptys Announces Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update

Anaptys Announces Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update •Announced rosnilimab, a PD-1 depleter and agonist, achieved positive results from Phase 2b rheumatoid arthritis (RA) trial and highest-ever reported CDAI LDA response over 6 months •Full clinical and translational data for rosnilimab in RA in Q2 2025 •Top-line Phase 2 data for rosnilimab in ulcerati

February 27, 2025 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name of Subsidiary Jurisdiction of Incorporation or Organization AnaptysBio Pty Ltd Australia

February 27, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: February 27, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

February 27, 2025 EX-10.21

Amended and Restated Employment Agreement, effective April 2

ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”) is made effective from April 25, 2022 (the “Effective Date”) by and among ANAPTYSBIO, INC. (the “Company”) and Dennis Mulroy (“CFO”). The Company and CFO are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.” This Agreement amen

February 19, 2025 EX-99.1

February 2025 Corporate Overview This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but n

February 2025 Corporate Overview This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from the Company’s clinical trials, including rosnilimab’s Phase 2b clinical trial in rheumatoid arth

February 19, 2025 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: February 19, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

February 18, 2025 EX-99.1

JOINT ACQUISITION STATEMENT PURSUANT TO RULE 13d-1(k)

EXHIBIT 99.1 JOINT ACQUISITION STATEMENT PURSUANT TO RULE 13d-1(k) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements. The undersigned

February 14, 2025 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of Common Stock of AnaptysBio, Inc. Date: February 14, 2025 FRAZIER LIFE SCIENCES PUBLIC FUND, L.P. By: FHMLSP, L.P.

February 14, 2025 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of Common Stock of AnaptysBio, Inc. Date: February 14, 2025 FRAZIER LIFE SCIENCES PUBLIC FUND, L.P. By: FHMLSP, L.P.

February 12, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: February 12, 2025 (Date of earliest event reported) ANAPTYSBIO, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: February 12, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

February 12, 2025 EX-99.1

Anaptys Announces Rosnilimab Achieved Positive Results in RA Phase 2b Trial and Highest Ever Reported CDAI LDA Response Over 6 Months • Achieved statistical significance on primary endpoint at Week 12 on mean change from baseline DAS- 28 CRP across a

rosnilimab2-12x25pr Anaptys Announces Rosnilimab Achieved Positive Results in RA Phase 2b Trial and Highest Ever Reported CDAI LDA Response Over 6 Months • Achieved statistical significance on primary endpoint at Week 12 on mean change from baseline DAS- 28 CRP across all rosnilimab doses vs.

February 12, 2025 EX-99.2

Feb. 12, 2025 Rosnilimab: Phase 2b Top-line Data in RA This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of

Feb. 12, 2025 Rosnilimab: Phase 2b Top-line Data in RA This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from the Company’s clinical trials, including rosnilimab’s Phase 2b clinical tr

February 3, 2025 EX-99.1

Vanda Pharmaceuticals and Anaptys Announce Exclusive Global License Agreement for Vanda to Develop and Commercialize Imsidolimab, an IL-36R Antagonist • Imsidolimab has successfully completed two global Phase 3 studies in Generalized Pustular Psorias

Vanda Pharmaceuticals and Anaptys Announce Exclusive Global License Agreement for Vanda to Develop and Commercialize Imsidolimab, an IL-36R Antagonist • Imsidolimab has successfully completed two global Phase 3 studies in Generalized Pustular Psoriasis • Vanda expects to immediately begin preparing BLA and MAA applications for the US and EU • Anaptys to receive $15 million from Vanda, comprised of a $10 million upfront payment and $5 million for existing drug supply • Anaptys to receive a 10% royalty on global net sales of imsidolimab WASHINGTON AND SAN DIEGO, Feb.

February 3, 2025 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 31, 2025 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

December 11, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: December 11, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

November 15, 2024 424B5

AnaptysBio, Inc. Common Stock

 As Filed Pursuant to Rule 424(b)(5)  Registration No. 333-283001 PROSPECTUS SUPPLEMENT (To Prospectus Dated November 15, 2024) AnaptysBio, Inc. $100,000,000 Common Stock We have entered into a sales agreement, or the sales agreement, with TD Securities (USA) LLC, or TD Cowen, relating to the sale of shares of our common stock, $0.001 par value per share, offered by this prospectus supplement and

November 14, 2024 SC 13G/A

ANAB / AnaptysBio, Inc. / Deep Track Capital, LP Passive Investment

SC 13G/A 1 deeptrack-anab093024a2.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* ANAPTYSBIO, INC. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriat

November 14, 2024 SC 13G/A

ANAB / AnaptysBio, Inc. / TANG CAPITAL MANAGEMENT LLC - AMENDMENT NO. 3 Passive Investment

SC 13G/A 1 anab1015240sc13ga3.htm AMENDMENT NO. 3 Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* AnaptysBio, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 032724106 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of This Statement) Check the ap

November 13, 2024 CORRESP

ANAPTYSBIO, INC. 10770 Wateridge Circle, Suite 210 San Diego, CA 92121

ANAPTYSBIO, INC. 10770 Wateridge Circle, Suite 210 San Diego, CA 92121 November 13, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Lauren Hamill Re: AnaptysBio, Inc. Registration Statement on Form S-3 (File No. 333-283001) Requested Date: November 15, 2024 Requested Time: 4:00 PM Eastern Time Ladies

November 5, 2024 EX-4.2

Form of Debt Security.

Exhibit 4.2 FORM OF DEBT SECURITY [Face of Security] ANAPTYSBIO, INC. [If applicable, insert—FOR PURPOSES OF THE ORIGINAL ISSUE DISCOUNT PROVISIONS OF THE INTERNAL REVENUE CODE OF 1986, THE ISSUE PRICE OF THIS SECURITY IS % OF ITS PRINCIPAL AMOUNT AT STATED MATURITY SET FORTH BELOW (ITS “PRINCIPAL AMOUNT”), THE AMOUNT OF ORIGINAL ISSUE DISCOUNT IS % OF ITS PRINCIPAL AMOUNT, THE YIELD TO MATURITY I

November 5, 2024 EX-FILING FEES

Filing Fee Table.

EXHIBIT 107 Calculation Of Filing Fee Tables Form S-3 (Form Type) AnaptysBio, Inc.

November 5, 2024 EX-99.1

Anaptys Announces Third Quarter 2024 Financial Results and Provides Business Update

Anaptys Announces Third Quarter 2024 Financial Results and Provides Business Update •Top-line Phase 2b data anticipated for ANB032, our BTLA agonist, in atopic dermatitis (AD) in December 2024 •Top-line Phase 2b data anticipated for rosnilimab, our PD-1 agonist, in rheumatoid arthritis (RA) in February 2025 •Phase 1 trial initiated in healthy volunteers for ANB033, our anti-CD122 antagonist •Reiterating cash runway through year-end 2026 SAN DIEGO, Nov.

November 5, 2024 EX-1.2

, 2024, by and between the Registrant and TD Securities (USA) LLC.

ANAPTYSBIO, INC. COMMON STOCK SALES AGREEMENT November 5, 2024 TD Securities (USA) LLC 1 Vanderbilt Avenue New York, New York 10022 Ladies and Gentlemen: AnaptysBio, Inc. (the “Company”), confirms its agreement (this “Agreement”) with TD Securities (USA) LLC (“TD Cowen”), as follows: 1. Issuance and Sale of Shares. The Company agrees that, from time to time during the term of this Agreement, on th

November 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2024 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, IN

November 5, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 5, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

November 5, 2024 EX-4.3

Form of Indenture.

Exhibit 4.3 ANAPTYSBIO, INC. And , as Trustee INDENTURE Dated as of , TABLE OF CONTENTS ARTICLE 1 - DEFINITIONS AND INCORPORATION BY REFERENCE 1.1. DEFINITIONS 1.2. OTHER DEFINITIONS 1.3. INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT 1.4. RULES OF CONSTRUCTION ARTICLE 2 - THE SECURITIES 2.1. ISSUABLE IN SERIES 2.2. ESTABLISHMENT OF TERMS OF SERIES OF SECURITIES 2.3. EXECUTION AND AUTHENTICATIO

November 5, 2024 S-3

As filed with the Securities and Exchange Commission on November 5, 2024

As filed with the Securities and Exchange Commission on November 5, 2024 Registration No.

August 16, 2024 SC 13D/A

ANAB / AnaptysBio, Inc. / EcoR1 Capital, LLC Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) James J. Frolik, Esq. Anthony J. Caldwell, Esq. Shartsis Friese LLP 425 Market Street, 11th Floor San Francisco, CA 94105 (Name, Addr

August 14, 2024 424B5

2,750,498 Shares Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-261953 PROSPECTUS SUPPLEMENT (To prospectus dated January 11, 2022) 2,750,498 Shares Common Stock We are offering 2,750,498 shares of our common stock in this offering. Our common stock is listed on The Nasdaq Global Select Market under the symbol “ANAB.” On August 13, 2024, the last reported sale price of our common sto

August 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 13, 2024 (Date of earliest event reported) ANAPTYSBIO, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 13, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

August 14, 2024 EX-1.1

Underwriting Agreement dated August 13, 2024

Exhibit 1.1 2,750,498 SHARES ANAPTYSBIO, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT August 13, 2024 TD SECURITIES (USA) LLC LEERINK PARTNERS LLC  As Representatives of the several Underwriters c/o TD Securities (USA) LLC 1 Vanderbilt Avenue New York, New York 10017 c/o Leerink Partners LLC 255 California Street, 5th Floor San Francisco, California 94111 Dear Sirs: 1. INTR

August 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2024 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (E

August 5, 2024 EX-99.1

Anaptys Announces Second Quarter 2024 Financial Results and Provides Business Update

Anaptys Announces Second Quarter 2024 Financial Results and Provides Business Update •Top-line data expected in December 2024 after having completed enrollment for Phase 2b trial to treat atopic dermatitis (AD) with ANB032, our BTLA agonist •Top-line data accelerated and now anticipated in Q1 2025 for Phase 2b trial to treat rheumatoid arthritis (RA) with rosnilimab, our PD-1 agonist •Top-line data now anticipated in Q1 2026 for Phase 2 trial to treat ulcerative colitis (UC) with rosnilimab •IND accepted by FDA for ANB033, our anti-CD122 antagonist; Phase 1 trial initiation anticipated in Q4 2024 SAN DIEGO, August 5, 2024 — AnaptysBio, Inc.

August 5, 2024 EX-10.29

eement, dated May 8, 2024 by and between the Registrant and Sagard Healthcare Partners Funding Borrower SPE

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT ANAPTYSBIO, INC.

August 5, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 5, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

August 5, 2024 S-8

As filed with the Securities and Exchange Commission on August 5, 2024

As filed with the Securities and Exchange Commission on August 5, 2024 Registration No.

August 5, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) AnaptysBio, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, $0.001 par value per sh

June 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 12, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 12, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

June 12, 2024 EX-10.1

2017 Equity Incentive Plan

anab-ar2017equityincenti 1 ANAPTYSBIO, INC. AMENDED AND RESTATED 2017 EQUITY INCENTIVE PLAN (AS AMENDED AND RESTATED June 12, 2024) 1. PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible persons whose present and potential contributions are important to the success of the Company, and any Parents and Subsidiaries that exist now or in the future, by o

May 9, 2024 EX-99.1

Anaptys Announces First Quarter 2024 Financial Results and Provides Business Update

Anaptys Announces First Quarter 2024 Financial Results and Provides Business Update •Enrollment ongoing for global Phase 2b trial to treat atopic dermatitis (AD) with ANB032, our BTLA agonist; reiterating top-line data anticipated by year-end 2024 •Enrollment ongoing for global Phase 2b trial to treat rheumatoid arthritis (RA) and global Phase 2 trial to treat ulcerative colitis (UC) with rosnilim

May 9, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 9, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 9, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number) (

May 9, 2024 EX-10.28

Amendment No. 1 to License Agreement, dated April 9, 2024, by and between the Registrant and Centessa Pharmaceuticals (UK) Limited.

1 AMENDMENT NO. 1 TO LICENSE AGREEMENT THIS AMENDMENT NO. 1 TO LICENSE AGREEMENT (this “Amendment”) dated as of the date of last signature, is entered into between ANAPTYSBIO, INC., a Delaware corporation (“AnaptysBio”), having a place of business at 10770 Wateridge Circle, Suite 210, San Diego, California 92121, and CENTESSA PHARMACEUTICALS (UK) LIMITED, a company incorporated in accordance with

May 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2024 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (

May 6, 2024 EX-99.A

AGREEMENT

EX-99.A 2 d792368dex99a.htm EX-99.A EXHIBIT A AGREEMENT Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of Common Stock of AnaptysBio, Inc. Date: May 6, 2024 FRAZIER LIFE SCIENCES PUBLIC FUND, L.P. By

May 6, 2024 SC 13G

ANAB / AnaptysBio, Inc. / Frazier Life Sciences Public Fund, L.P. - SC 13G Passive Investment

SC 13G 1 d792368dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* AnaptysBio, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 032724106 (CUSIP Number) April 29, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule p

April 24, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a Party other than the Registrant ☐ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

April 24, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Ru

March 11, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) AnaptysBio, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, $0.001 par value per sh

March 11, 2024 EX-10.19

Amendment No. 5 to Tesaro AnaptysBio Collaboration

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT ANAPTYSBIO, INC.

March 11, 2024 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name of Subsidiary Jurisdiction of Incorporation or Organization AnaptysBio Pty Ltd Australia

March 11, 2024 EX-10.18

, dated November 24, 2023, by and between the Re

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT ANAPTYSBIO, INC.

March 11, 2024 EX-97

Compensation Recovery Policy

ANAPTYSBIO, INC. COMPENSATION RECOVERY POLICY (Adopted September 15, 2023) The Board has determined that it is in the best interests of the Company and its stockholders to adopt this Policy enabling the Company to recover from specified current and former Company executives certain incentive-based compensation in the event of an accounting restatement resulting from material noncompliance with any

March 11, 2024 S-8

As filed with the Securities and Exchange Commission on March 11, 2024

As filed with the Securities and Exchange Commission on March 11, 2024 Registration No.

March 11, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 11, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 11, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

March 11, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number: 001-37985 ANAPTYSBIO, INC. (Exact n

March 11, 2024 EX-99.1

Anaptys Announces Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update

Anaptys Announces Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update •Enrollment ongoing for global Phase 2b trial to treat atopic dermatitis (AD) with ANB032, our BTLA agonist, with top-line data anticipated by year-end 2024 •Enrollment ongoing for global Phase 2b trial to treat rheumatoid arthritis (RA) and global Phase 2 trial to treat ulcerative colitis (UC) with

February 14, 2024 SC 13G/A

ANAB / AnaptysBio, Inc. / Deep Track Capital, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2024 SC 13G/A

ANAB / AnaptysBio, Inc. / Point72 Asset Management, L.P. - ANAPTYSBIO, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Anaptysbio, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 032724106 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to w

February 14, 2024 SC 13G/A

ANAB / AnaptysBio, Inc. / TANG CAPITAL PARTNERS LP - AMENDMENT NO. 2 Passive Investment

SC 13G/A 1 z111240sc13ga2.htm AMENDMENT NO. 2 Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* AnaptysBio, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 032724106 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropr

February 13, 2024 SC 13G/A

ANAB / AnaptysBio, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 5)* Name of issuer: AnaptysBio Inc Title of Class of Securities: Common Stock CUSIP Number: 032724106 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rule

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 5, 2024 (Date of earliest event reported) ANAPTYSBIO, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 5, 2024 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

January 5, 2024 EX-99.1

January 2024 Corporate Overview Nasdaq: ANAB This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, incl

January 2024 Corporate Overview Nasdaq: ANAB This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from the Company’s clinical trials, including rosnilimab’s Phase 2b clinical trial in rhe

November 27, 2023 EX-99.1

Anaptys Expands Immune Cell Modulator Pipeline with Exclusive License to BDCA2 Modulator Antibody Portfolio from Centessa Pharmaceuticals

Anaptys Expands Immune Cell Modulator Pipeline with Exclusive License to BDCA2 Modulator Antibody Portfolio from Centessa Pharmaceuticals •Anaptys licenses exclusive global development and commercialization rights to a potential best-in-class BDCA2 modulator portfolio •IND filing to support clinical development of ANB101 in autoimmune and inflammatory diseases expected in H2 2024 •Reiterating year-end 2023 cash and investments of $400 to $410 million and cash runway through year-end 2026 SAN DIEGO, Nov.

November 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 24, 2023 (Date of earliest event reported) ANAPTYSBIO, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 24, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

November 2, 2023 EX-99.1

Anaptys Announces Third Quarter 2023 Financial Results and Provides Business Update

Anaptys Announces Third Quarter 2023 Financial Results and Provides Business Update •Initiated a global Phase 2b trial to treat rheumatoid arthritis (RA) with rosnilimab, our PD-1 agonist •Initiating in Q4 2023 a global Phase 2 trial to treat ulcerative colitis (UC) with rosnilimab •Announced positive top-line Phase 3 clinical trial results of imsidolimab (IL-36R) in generalized pustular psoriasis (GPP) •Reiterating cash runway through year-end 2026 and updating expected year-end 2023 cash and investments of $400 to $410 million SAN DIEGO, Nov.

November 2, 2023 EX-10.27

Amended and Restated Employment Agreement, effective August 4, 2023, by and between the Registrant and Daniel Faga

ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”) is made effective as of August 4, 2023 (the “Effective Date”), by and among ANAPTYSBIO, INC. (the “Company”) and Daniel Faga (“Executive”). The Company and Executive are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.” This Ag

November 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 2, 2023 (Date of earliest event reported) ANAPTYSBIO, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 2, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

November 2, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2023 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, IN

October 25, 2023 EX-99.1

EX-99.1

October 25, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 25, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

October 10, 2023 EX-99.1

Anaptys Announces Positive Top-Line Phase 3 Clinical Trial Results of Imsidolimab (IL-36R) in Generalized Pustular Psoriasis (GPP) • 53.3% of patients who received a single dose of 750mg IV imsidolimab achieved GPPPGA 0/1 (clear or almost clear) at W

anaptysannouncespositive Anaptys Announces Positive Top-Line Phase 3 Clinical Trial Results of Imsidolimab (IL-36R) in Generalized Pustular Psoriasis (GPP) • 53.

October 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 9, 2023 (Date of earliest event reported) ANAPTYSBIO, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 9, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

October 2, 2023 SC 13G

ANAB / AnaptysBio Inc / Deep Track Capital, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

September 18, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: September 14, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Nu

August 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 7, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 7, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

August 7, 2023 EX-10.26

Amended and Restated Certificate of Incorporation, as currently in effect.

anaptysbioinc-derestated Delaware The First State Page 1 4062359 8100 Authentication: 203663607 SR# 20232896198 Date: 06-30-23 You may verify this certificate online at corp.

August 7, 2023 EX-99.1

AnaptysBio Announces Second Quarter 2023 Financial Results and Provides Business Update

AnaptysBio Announces Second Quarter 2023 Financial Results and Provides Business Update •Completed enrollment of the GEMINI-1 Phase 3 trial for imsidolimab (IL-36R) in generalized pustular psoriasis (GPP) and anticipate top-line data in Q4 2023 •Initiating a global Phase 2b trial for rosnilimab, a PD-1 agonist antibody, in rheumatoid arthritis (RA) later in Q3 2023 and a second Phase 2 trial, in an indication yet to be announced, by year-end 2023 •Daniel Faga appointed to the permanent position of president and chief executive officer •Reiterating cash runway through year-end 2026 and updated expected year-end 2023 cash and investments of $380 – $395 million SAN DIEGO, August 7, 2023 — AnaptysBio, Inc.

August 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2023 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (E

June 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 15, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 15, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

May 11, 2023 EX-99.1

AnaptysBio Announces First Quarter 2023 Financial Results and Provides Pipeline Update

AnaptysBio Announces First Quarter 2023 Financial Results and Provides Pipeline Update •Initiated a global Phase 2b trial to treat atopic dermatitis with ANB032, a BTLA agonist •Hosting a virtual BTLA Agonist (ANB032) R&D Event on May 25, 2023 •Announced International Societies for Investigative Dermatology (ISID) Annual Meeting poster presentation for ANB032, a BTLA agonist, Phase 1 data •Initiating a global Phase 2b trial to treat rheumatoid arthritis in Q3 2023 and a second Phase 2 trial, in an indication to be announced, by year-end 2023 with rosnilimab, a PD-1 agonist •Reiterating cash runway through year-end 2026 with expected year-end 2023 cash and investments of $370 – $385 million SAN DIEGO, May 11, 2023 — AnaptysBio, Inc.

May 11, 2023 EX-10.25

Amended and Restated Employment Agreement, effective

loumeauthirdamemployment ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (this “Agreement”) is made effective from May 8, 2023 (the “Effective Date”) by and among AnaptysBio, Inc. (the “Company”) and Eric Loumeau (“Executive”). The Company and Executive are hereinafter collectively referred to as the “Parties,” and individually referred to

May 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 11, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 11, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

May 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2023 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (

April 27, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a Party other than the Registrant ☐ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

April 27, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A 1 proxystatementadditionalma.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, f

April 14, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ¨ Defini

April 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: April 1, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: April 1, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

March 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 1, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 1, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

March 1, 2023 EX-99.1

AnaptysBio Announces Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update

AnaptysBio Announces Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update •Initiating a global Phase 2b trial for rosnilimab (PD-1 agonist) to treat rheumatoid arthritis anticipated Q3 2023 •Initiating a global Phase 2b trial for ANB032 (BTLA agonist) to treat atopic dermatitis anticipated Q2 2023 •Initiating second Phase 2 trial for rosnilimab in an indication to be announced anticipated year-end 2023 •Filing IND for ANB033 (anti-CD122 antagonist) anticipated H1 2024 •Top-line data from the GEMINI-1 Phase 3 trial for imsidolimab (anti-IL-36R antagonist) to treat GPP anticipated Q4 2023 •Reiterating cash runway through year end 2026 SAN DIEGO, March 1, 2023 — AnaptysBio, Inc.

March 1, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) AnaptysBio, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, $0.001 par value per sh

March 1, 2023 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name of Subsidiary Jurisdiction of Incorporation or Organization AnaptysBio Pty Ltd Australia

March 1, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number: 001-37985 ANAPTYSBIO, INC. (Exact n

March 1, 2023 S-8

As filed with the Securities and Exchange Commission on March 1, 2023

As filed with the Securities and Exchange Commission on March 1, 2023 Registration No.

February 14, 2023 SC 13G/A

ANAB / AnaptysBio Inc / Point72 Asset Management, L.P. - SCHEDULE 13G/A, AMENDMENT #1 Passive Investment

SC 13G/A 1 pt7213ga.htm SCHEDULE 13G/A, AMENDMENT #1 240.13d-102 Schedule 13G - Information to be included in statements filed pursuant to 240.13d-1(b), (c), and (d) and amendments thereto filed pursuant to 240.13d-2. Securities and Exchange Commission, Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* (Name of Issuer) AnaptysBio, Inc. (Title of Class

February 10, 2023 EX-3.1

Second Amended and Restated Bylaws of the Registrant

ANAPTYSBIO, INC., a Delaware Corporation SECOND AMENDED AND RESTATED BYLAWS As Amended and Restated on February 7, 2023 ANAPTYSBIO, INC., a Delaware Corporation SECOND AMENDED AND RESTATED BYLAWS TABLE OF CONTENTS Article I - STOCKHOLDERS Section 1.1: Annual Meetings Section 1.2: Special Meetings Section 1.3: Notice of Meetings Section 1.4: Adjournments Section 1.5: Quorum Section 1.6: Organizatio

February 10, 2023 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: February 7, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

February 10, 2023 SC 13G/A

ANAB / AnaptysBio Inc / Flynn James E Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No.

February 9, 2023 SC 13G/A

ANAB / AnaptysBio Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 4)* Name of issuer: AnaptysBio Inc. Title of Class of Securities: Common Stock CUSIP Number: 032724106 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rul

February 9, 2023 SC 13G/A

ANAB / AnaptysBio Inc / FEDERATED HERMES, INC. Passive Investment

SC 13G/A 1 form877.htm OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3*) ANAPTYSBIO, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 032724106 (CUSIP Number) January 31, 2023 (Date of Event Which Requir

February 1, 2023 SC 13G/A

ANAB / AnaptysBio Inc / FEDERATED HERMES, INC. Passive Investment

SC 13G/A 1 form815.htm OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2*) ANAPTYSBIO, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 032724106 (CUSIP Number) December 31, 2022 (Date of Event Which Requi

January 13, 2023 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 13, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

January 13, 2023 EX-99.1

AnaptysBio Announces Stock Repurchase Plan

AnaptysBio Announces Stock Repurchase Plan SAN DIEGO, Jan. 13, 2023 — AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, today announced that its Board of Directors has authorized a Stock Repurchase Plan under which the Company may repurchase up to $50,000,000 of the Company’s outstanding common stock, par value $0.001

January 5, 2023 EX-99.1

AnaptysBio Announces Portfolio Update Across Best-in-Class Immune Cell Modulating Antibodies

AnaptysBio Announces Portfolio Update Across Best-in-Class Immune Cell Modulating Antibodies ?Advancing rosnilimab, its PD-1 agonist, into a global Phase 2b trial to treat rheumatoid arthritis with study initiation in Q3 2023 ?Advancing ANB032, its BTLA agonist, into a global Phase 2b trial to treat atopic dermatitis with study initiation in Q2 2023 ?Advancing rosnilimab into a second Phase 2 tria

January 5, 2023 EX-99.2

Corporate Overview January 2022 Nasdaq: ANAB 2 This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, in

Corporate Overview January 2022 Nasdaq: ANAB 2 This presentation and any accompanying oral presentation contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of initiation of the Company?s clinical trials, including rosnilimab?s clinical trials in rheumatoid arthritis

January 5, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 5, 2023 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

November 8, 2022 EX-10.24

Sales Agreement, dated November 8, 2022, by and between the Registrant and Cowen and Company, LLC

Exhibit 10.24 ANAPTYSBIO, INC. $150,000,000 COMMON STOCK SALES AGREEMENT November 8, 2022 Cowen and Company, LLC 599 Lexington Avenue New York, NY 10022 Ladies and Gentlemen: AnaptysBio, Inc. (the ?Company?), confirms its agreement (this ?Agreement?) with Cowen and Company, LLC (?Cowen?), as follows: 1. Issuance and Sale of Shares. The Company agrees that, from time to time during the term of this

November 8, 2022 EX-10.23

Purchase and Sale Agreement, dated September 9, 2022, by and between the Registrant and DRI Healthcare Acquisitions L.P.

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMEMNT, MARKED BY [***], HAS BEEN OMITTED BECAUSE THE INFORMATION IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL.

November 8, 2022 424B5

AnaptysBio, Inc. Common Stock

Filed Pursuant to Rule 424(b)(5) Registration No. 333-261953 PROSPECTUS SUPPLEMENT (To Prospectus Dated January 11, 2022) AnaptysBio, Inc. $150,000,000 Common Stock We have entered into a sales agreement with Cowen and Company, LLC, or Cowen, relating to the sale of shares of our common stock, $0.001 par value per share, offered by this prospectus supplement and the accompanying base prospectus. I

November 8, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 8, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2022 OR ? Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, IN

November 8, 2022 EX-99.2

Corporate Overview November 2022 Nasdaq: ANAB 2 This presentation and any accompanying oral presentation contain “forward‐looking” statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995,

Corporate Overview November 2022 Nasdaq: ANAB 2 This presentation and any accompanying oral presentation contain ?forward?looking? statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from our clinical trials, including imsidolimab?s Phase 3 trial in GPP and rosnilimab

November 8, 2022 EX-99.1

AnaptysBio Announces Third Quarter 2022 Financial Results and Provides Pipeline Update

AnaptysBio Announces Third Quarter 2022 Financial Results and Provides Pipeline Update ?Anticipate Rosnilimab, our anti-PD-1 agonist antibody, top-line data in the ongoing AZURE Phase 2 trial in moderate-to-severe alopecia areata in Q1 2023 ?Anticipate ANB032, our anti-BTLA agonist antibody, U.

September 12, 2022 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: September 9, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

September 12, 2022 EX-99.1

Corporate Overview September 2022 Nasdaq: ANAB 2 This presentation and any accompanying oral presentation contain “forward‐looking” statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995,

Corporate Overview September 2022 Nasdaq: ANAB 2 This presentation and any accompanying oral presentation contain ?forward?looking? statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from our clinical trials, including imsidolimab?s Phase 3 trial in GPP and rosnilima

September 9, 2022 SC 13G

ANAB / AnaptysBio Inc / Point72 Asset Management, L.P. - SCHEDULE 13G Passive Investment

240.13d-102 Schedule 13G - Information to be included in statements filed pursuant to 240.13d-1(b), (c), and (d) and amendments thereto filed pursuant to 240.13d-2. Securities and Exchange Commission, Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. )* (Name of Issuer) AnaptysBio, Inc. (Title of Class of Securities) Common Stock, $0.001 Par Value Per Sha

September 9, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessi

August 31, 2022 EX-99.1

AnaptysBio Reports HARP Phase 2 Top-Line Data of Imsidolimab in Moderate-to-Severe Hidradenitis Suppurativa

AnaptysBio Reports HARP Phase 2 Top-Line Data of Imsidolimab in Moderate-to-Severe Hidradenitis Suppurativa ?Imsidolimab (anti-IL-36 receptor antagonist) did not demonstrate improvement over placebo in the primary endpoint and key secondary endpoints ?Imsidolimab was safe and well tolerated with no imsidolimab-related serious or severe adverse events reported ?Company to discontinue imsidolimab cl

August 31, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 31, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

August 15, 2022 SC 13G

ANAB / AnaptysBio Inc / Flynn James E Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No.

August 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2022 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (E

August 8, 2022 EX-99.1

AnaptysBio Announces Second Quarter 2022 Financial Results and Provides Pipeline Update

AnaptysBio Announces Second Quarter 2022 Financial Results and Provides Pipeline Update ?Top-line data from the ongoing imsidolimab (anti-IL-36R Ab) HARP Phase 2 trial in moderate-to-severe hidradenitis suppurativa is anticipated in Q3 2022 ?Top-line data from the ongoing rosnilimab (anti-PD-1 agonist Ab) AZURE Phase 2 trial in moderate-to-severe alopecia areata is anticipated in Q1 2023 SAN DIEGO, August 8, 2022 - AnaptysBio, Inc.

August 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 8, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

June 24, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 23, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

May 10, 2022 SC 13G/A

ANAB / AnaptysBio Inc / FEDERATED HERMES, INC. Passive Investment

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ?.11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1*) ANAPTYBIO, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 032724106 (CUSIP Number) April 30, 2022 (Date of Event Which Requires Filing of this Statemen

May 4, 2022 EX-10.20

Employment Agreement, effective March 21, 2022, by and between Registrant and Daniel Faga

May 4, 2022 EX-10.22

, 2022, by and between Registrant and Hamza Suria

CONSULTING AGREEMENT This Consulting Agreement (?Agreement?) is effective as of March 21, 2022 (the ?Effective Date?), between AnaptysBio, Inc.

May 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2022 OR ? Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (

May 4, 2022 EX-10.21

Separation Agreement effective March 20, 2022, by and between Registrant and Hamza Suria

March 17, 2022 VIA E-MAIL Hamza Suria [email protected] Re: Terms of Separation Dear Hamza: This letter confirms the agreement (?Agreement?) between you and AnaptysBio, Inc. (the ?Company?) concerning the terms of your separation and offers you the Separation Compensation we discussed in exchange for a general release of claims and covenant not to sue. 1. Separation Date: March 20, 2022 is your

May 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 4, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number) (

May 4, 2022 EX-99.1

AnaptysBio Announces First Quarter 2022 Financial Results and Provides Pipeline Update

AnaptysBio Announces First Quarter 2022 Financial Results and Provides Pipeline Update ?Top-line data from the ongoing imsidolimab (anti-IL-36R Ab) HARP Phase 2 trial in moderate-to-severe hidradenitis suppurativa is anticipated in Q3 2022 ?Top-line data from the ongoing imsidolimab GEMINI-1 Phase 3 trial in GPP is anticipated in Q4 2023 ?Top-line data from the ongoing rosnilimab (anti-PD-1 agonist Ab) AZURE Phase 2 trial in moderate-to-severe alopecia areata is anticipated in H1 2023 ?Ended Q1 2022 with approximately $596.

April 29, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defini

April 29, 2022 EX-10.3

Amended and Restated Employment Agreement, effective April 25, 2022, by and between the Registrant and Dennis Mulroy

ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this ?Agreement?) is made effective from July 15, 2020 (the ?Effective Date?) by and among ANAPTYSBIO, INC. (the ?Company?) and Dennis Mulroy (?CFO?). The Company and CFO are hereinafter collectively referred to as the ?Parties,? and individually referred to as a ?Party.? This Agreement amend

April 29, 2022 EX-10.1

Amended and Restated Employment Agreement, effective April 25, 2022, by and between Registrant and Paul Lizzul

ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this ?Agreement?) is made effective from April 25, 2022 (the ?Effective Date?) by and among ANAPTYSBIO, INC. (the ?Company?) and Paul Lizzul, MD (?CMO?). The Company and CMO are hereinafter collectively referred to as the ?Parties,? and individually referred to as a ?Party.? This Agreement am

April 29, 2022 EX-10.2

Amended and Restated Employment Agreement, effective April 25, 2022, by and between the Registrant and Eric Loumeau

ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (this ?Agreement?) is made effective from April 25, 2022 (the ?Effective Date?) by and among AnaptysBio, Inc. (the ?Company?) and Eric Loumeau (?Executive?). The Company and Executive are hereinafter collectively referred to as the ?Parties,? and individually referred to as a ?Party.? This Agr

April 29, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Ru

April 29, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: April 25, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

April 27, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: April 27, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

April 27, 2022 EX-99.1

AnaptysBio Announces Positive ANB032 (anti-BTLA agonist) Top-Line Phase 1 Data and Provides Pipeline Updates

AnaptysBio Announces Positive ANB032 (anti-BTLA agonist) Top-Line Phase 1 Data and Provides Pipeline Updates ?ANB032, our wholly owned anti-BTLA agonist antibody, demonstrated favorable safety, tolerability and a rapid and sustained pharmacokinetic and pharmacodynamic profile that supports advancement of ANB032 into subsequent patient trials ?ANB032 IND filing in an initial proof-of-concept Phase 2 trial is anticipated in the second half of 2022 ?Imsidolimab (anti-IL-36R Ab) top-line data from the Phase 2 trial in moderate-to-severe hidradenitis suppurativa is anticipated in the third quarter of 2022 SAN DIEGO, April 27, 2022 - AnaptysBio, Inc.

March 21, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 20, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

March 14, 2022 EX-99.1

AnaptysBio Reports Imsidolimab ACORN Phase 2 Clinical Trial Data in Moderate-to-Severe Acne

AnaptysBio Reports Imsidolimab ACORN Phase 2 Clinical Trial Data in Moderate-to-Severe Acne ?Imsidolimab (anti-IL-36R Ab) treatment did not demonstrate improvement over placebo in top-line primary or secondary endpoints ?AnaptysBio to discontinue imsidolimab clinical development in acne ?Imsidolimab was generally safe, well tolerated and no imsidolimab-related serious or severe adverse events were

March 14, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 14, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

March 7, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number: 001-37985 ANAPTYSBIO, INC. (Exact n

March 7, 2022 EX-10.19

Amendment No. 4 to Tesaro AnaptysBio Collaboration

AMENDMENT NO. 4 TO COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT This Amendment No. 4 to the Collaboration and Exclusive License Agreement (this ?Amendment?) effective as of October 21, 2021 (the ?Amendment Date?), is entered into by and between (i) AnaptysBio, Inc., a Delaware corporation, having a place of business at 10770 Wateridge Circle, Suite 210, San Diego, California 92121 (?AnaptysBio?),

March 7, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) AnaptysBio, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, $0.001 par value per sh

March 7, 2022 S-8

As filed with the Securities and Exchange Commission on March 7, 2022

As filed with the Securities and Exchange Commission on March 7, 2022 Registration No.

March 7, 2022 EX-99.1

AnaptysBio Announces Fourth Quarter and Full Year 2021 Financial Results and Provides Pipeline Update

AnaptysBio Announces Fourth Quarter and Full Year 2021 Financial Results and Provides Pipeline Update ?Imsidolimab GPP GALLOP Phase 2 16-week data presented at 2021 EADV Congress and Phase 3 GPP GEMINI-1 trial initiated ?Top-line data anticipated from ongoing imsidolimab ACORN Phase 2 trial in moderate-to-severe acne in H1 2022 and HARP Phase 2 trial in moderate-to-severe hidradenitis suppurativa

March 7, 2022 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name of Subsidiary Jurisdiction of Incorporation or Organization AnaptysBio Pty Ltd Australia

March 7, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 7, 2022 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

February 15, 2022 SC 13G/A

ANAB / AnaptysBio Inc / PERCEPTIVE ADVISORS LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 032724 106 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rul

February 15, 2022 EX-99.1

AGREEMENT

EX-99.1 EXHIBIT 1 AGREEMENT The persons below hereby agree that the Schedule 13G to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13G, shall be filed on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934. Date: February 14, 2022 PERCEPTIVE ADVISORS LLC

February 14, 2022 SC 13G

ANAB / AnaptysBio Inc / FEDERATED HERMES, INC. Passive Investment

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. *) ANAPTYBIO, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 032724106 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statem

February 14, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessi

February 14, 2022 SC 13G/A

ANAB / AnaptysBio Inc / Point72 Asset Management, L.P. - SCHEDULE 13G (AMENDMENT NO. 1) Passive Investment

240.13d-102 Schedule 13G - Information to be included in statements filed pursuant to 240.13d-1(b), (c), and (d) and amendments thereto filed pursuant to 240.13d-2. Securities and Exchange Commission, Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* (Name of Issuer) Anaptysbio, Inc. (Title of Class of Securities) Common Stock, $0.001 Par Value Per Sh

February 9, 2022 SC 13G/A

ANAB / AnaptysBio Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv0262-anaptysbioinc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 3)* Name of issuer: AnaptysBio Inc. Title of Class of Securities: Common Stock CUSIP Number: 032724106 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the r

January 7, 2022 CORRESP

* * *

ANAPTYSBIO, INC. 10770 Wateridge Circle, Suite 210 San Diego, CA 92121 January 7, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Michael Davis Re: AnaptysBio, Inc. Registration Statement on Form S-3 (File No. 333-261953) filed December 30, 2021. Requested Date: January 11, 2022 Requested Time: 4:00

December 30, 2021 S-3

As filed with the Securities and Exchange Commission on December 30, 2021

Table of Contents As filed with the Securities and Exchange Commission on December 30, 2021 Registration No.

December 30, 2021 EX-1.2

Open Market Sale AgreementSM, dated December 30, 2021, between the Registrant and Jefferies LLC

EX-1.2 2 d282430dex12.htm EX-1.2 Exhibit 1.2 OPEN MARKET SALE AGREEMENTSM December 30, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: AnaptysBio, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), sha

December 30, 2021 EX-4.3

Form of Indenture

Exhibit 4.3 ANAPTYSBIO, INC. And , as Trustee INDENTURE Dated as of , TABLE OF CONTENTS ARTICLE 1 - DEFINITIONS AND INCORPORATION BY REFERENCE 1 1.1. DEFINITIONS 1 1.2. OTHER DEFINITIONS 4 1.3. INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT 5 1.4. RULES OF CONSTRUCTION 6 ARTICLE 2 - THE SECURITIES 6 2.1. ISSUABLE IN SERIES 6 2.2. ESTABLISHMENT OF TERMS OF SERIES OF SECURITIES 6 2.3. EXECUTION A

December 1, 2021 8-K

Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: December 1, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

December 1, 2021 EX-2.1

Royalty Purchase Agreement, dated October 25, 2021, by and between the Registrant and Sagard Healthcare Royalty Partners, LP

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE THE INFORMATION IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

November 29, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 26, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

November 15, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 15, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

November 15, 2021 EX-99.1

AnaptysBio Announces Positive Rosnilimab Healthy Volunteer Phase 1 Top-Line Data

AnaptysBio Announces Positive Rosnilimab Healthy Volunteer Phase 1 Top-Line Data ?Rosnilimab, AnaptysBio?s wholly-owned anti-PD-1 agonist antibody, demonstrated favorable safety and tolerability in single and multiple ascending dose healthy volunteer cohorts ?Robust pharmacokinetic profile, in conjunction with rapid and sustained PD-1 receptor occupancy ?Pharmacodynamic activity resulted in dose-d

November 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2021 OR ? Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, IN

November 4, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 4, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

November 4, 2021 EX-99.1

AnaptysBio Announces Third Quarter 2021 Financial Results and Provides Pipeline Updates

AnaptysBio Announces Third Quarter 2021 Financial Results and Provides Pipeline Updates ?Imsidolimab GPP GALLOP Phase 2 16-week data presented at 2021 EADV Congress and GEMINI-1 Phase 3 trial initiated subsequent to FDA end-of-Phase 2 meeting ?Top-line data from ongoing imsidolimab ACORN Phase 2 trial in moderate-to-severe acne anticipated in H1 2022 and HARP Phase 2 trial in moderate-to-severe hi

October 25, 2021 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 25, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

October 4, 2021 EX-99.1

AnaptysBio Presents Updated Data From Imsidolimab Phase 2 GALLOP Trial in Generalized Pustular Psoriasis

AnaptysBio Presents Updated Data From Imsidolimab Phase 2 GALLOP Trial in Generalized Pustular Psoriasis ?Imsidolimab demonstrated rapid and sustained efficacy with 6 of 8 (75%) generalized pustular psoriasis (GPP) patients achieving the primary endpoint at week 4 and week 16 ?Early reduction of erythema with pustules by 60% at week 1 improved to 94% reduction at week 4 and 98% reduction at week 1

October 4, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 4, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

August 9, 2021 EX-99.1

AnaptysBio Announces Second Quarter 2021 Financial Results and Provides Pipeline Updates

AnaptysBio Announces Second Quarter 2021 Financial Results and Provides Pipeline Updates ?Imsidolimab GPP GEMINI-1 Phase 3 trial anticipated to initiate in Q3 2021 following recent FDA end-of-Phase 2 Meeting ?Imsidolimab GALLOP GPP Phase 2 trial 16-week data to be orally presented at the EADV Congress on October 2nd, 2021 ?Imsidolimab Phase 2 trials ongoing in acne, hidradenitis suppurativa, EGFR-

August 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2021 OR ? Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (E

August 9, 2021 EX-10.19

First Amendment to Lease Agreement

FIRST AMENDMENT TO LEASE AGREEMENT This FIRST AMENDMENT TO LEASE AGREEMENT (?Amendment?) is effective as of April 5, 2021 (?Amendment Effective Date?), by and between WATERIDGE PROPERTY OWNER, LP, a Delaware limited partnership (?Landlord?), and ANAPTYSBIO, INC.

August 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 9, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number

June 17, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 17, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Number)

June 3, 2021 EX-99.1

AnaptysBio Presentation

EX-99.1 2 a632021presentation.htm ANAPTYSBIO PRESENTATION

June 3, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 3, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numb

May 11, 2021 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CUSIP N

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) James J. Frolik, Esq. Anthony J. Caldwell, Esq. Shartsis Friese LLP One Maritime Plaza, 18th Floor San Francisco, CA 94111 (Name, Add

May 4, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 4, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

May 4, 2021 EX-99.1

AnaptysBio Announces First Quarter 2021 Financial Results and Provides Pipeline Updates

AnaptysBio Announces First Quarter 2021 Financial Results and Provides Pipeline Updates ?Imsidolimab Phase 3 GPP trial anticipated to commence in mid-2021 following FDA end-of-Phase 2 meeting held during Q2 2021 ?JEMPERLI (dostarlimab), our PD-1 antagonist antibody partnered with GlaxoSmithKline (GSK), was approved for endometrial cancer in the US and EU during Q2 2021, earning $30 million in cash

May 4, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2021 OR ? Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (

April 26, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Ru

April 26, 2021 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Defin

April 13, 2021 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CUSIP N

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) James J. Frolik, Esq. Anthony J. Caldwell, Esq. Shartsis Friese LLP One Maritime Plaza, 18th Floor San Francisco, CA 94111 (Name, Add

April 12, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: April 8, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

March 10, 2021 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. ___)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CUSIP

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) James J. Frolik, Esq. Anthony J. Caldwell, Esq. Shartsis Friese LLP One Maritime Plaza, 18th Floor San Francisco, CA 94111 (Name, Addr

March 10, 2021 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. ___)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CUSIP

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) James J. Frolik, Esq. Anthony J. Caldwell, Esq. Shartsis Friese LLP One Maritime Plaza, 18th Floor San Francisco, CA 94111 (Name, Addr

March 8, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: March 8, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

March 8, 2021 EX-99.1

AnaptysBio Reports Imsidolimab POPLAR Phase 2 Clinical Trial in Moderate-to-Severe Palmoplantar Pustulosis (PPP) Did Not Meet Primary Endpoint

AnaptysBio Reports Imsidolimab POPLAR Phase 2 Clinical Trial in Moderate-to-Severe Palmoplantar Pustulosis (PPP) Did Not Meet Primary Endpoint ?Imsidolimab treatment did not demonstrate statistically significant improvement over placebo in PPPASI change from baseline at week 16 primary endpoint ?Imsidolimab was generally well tolerated and no serious or severe adverse events were reported in the drug arm of the trial ?AnaptysBio does not currently plan to conduct further clinical development in PPP ?Advancement of imsidolimab to continue across 5 other distinct indications, including anticipated advancement into Phase 3 trial in generalized pustular psoriasis (GPP) in mid-2021 SAN DIEGO, March 8th, 2021 ? AnaptysBio, Inc.

February 25, 2021 EX-10.16

Amendment No. 3 to the Collaboration and Exclusive License Agreement

CERTAIN CONFIDENTIAL INFORMATION MARKED [***] HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

February 25, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on February 25, 2021 Registration No.

February 25, 2021 EX-10.18

Confidential Settlement and Modification Agreement dated as of October 23, 2020

CERTAIN CONFIDENTIAL INFORMATION MARKED [***] HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

February 25, 2021 EX-10.17

Termination of Sublease

TERMINATION OF SUBLEASE (Early Termination) THIS TERMINATION OF SUBLEASE (this "Agreement") is dated as of November 11, 2020, between TREX ENTERPRISES CORPORATION, a California corporation ("Sublessor"), and ANAPTYSBIO, INC.

February 25, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: February 25, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

February 25, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number: 001-37985 ANAPTYSBIO, INC. (Exact n

February 25, 2021 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name of Subsidiary Jurisdiction of Incorporation or Organization AnaptysBio Pty Ltd Australia

February 25, 2021 EX-99.1

AnaptysBio Announces Fourth Quarter and Full Year 2020 Financial Results and Provides Pipeline Updates

AnaptysBio Announces Fourth Quarter and Full Year 2020 Financial Results and Provides Pipeline Updates ?Positive topline data from GALLOP Phase 2 clinical trial of imsidolimab in moderate to severe generalized pustular psoriasis (GPP) announced in October 2020, with Phase 3 trial initiation anticipated in mid-2021 ?Topline data from POPLAR Phase 2 imsidolimab clinical trial in palmoplantar pustulo

February 16, 2021 SC 13G/A

Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* AnaptysBio, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) (CUSIP Numbe

Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

February 11, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) December 31, 2020

February 10, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 2)*

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 2)* Name of issuer: AnaptysBio Inc. Title of Class of Securities: Common Stock CUSIP Number: 032724106 Date of Event Which Requires Filing of this Statement: December 31, 2020 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rul

February 8, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities)

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 032724 106 (CUSIP Number) January 28, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

January 19, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 18, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

January 14, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CUSIP Nu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 032724106 (CUSIP Number) January 4, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to wh

January 13, 2021 SC 13G

CUSIP No. 032724106

240.13d-102 Schedule 13G - Information to be included in statements filed pursuant to 240.13d-1(b), (c), and (d) and amendments thereto filed pursuant to 240.13d-2. Securities and Exchange Commission, Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.)* (Name of Issuer) Anaptysbio, Inc. (Title of Class of Securities) Common Stock, $0.001 Par Value (CUSIP N

January 13, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessi

January 11, 2021 EX-99.1

AnaptysBio Presentation, dated January 2021.

January 11, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: January 11, 2021 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

November 18, 2020 SC 13D/A

ANAB / AnaptysBio, Inc. / Frazier Healthcare V, LP - AMENDMENT NO. 3 TO SCHEDULE 13D Activist Investment

Amendment No. 3 to Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4)* AnaptysBio, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 032724106 (CUSIP Number) Steve R. Bailey Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle, WA 98101

November 17, 2020 8-K

Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 11, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

November 4, 2020 EX-10.18

Employment Agreement, effective July 15, 2020, by and between Registrant and Dennis Mulroy

ANAPTYSBIO, INC. EMPLOYMENT AGREEMENT This EMPLOYMENT AGREEMENT (this “Agreement”) is made effective from July 15, 2020 (the “Effective Date”) by and among ANAPTYSBIO, INC. (the “Company”) and Dennis Mulroy (“CFO”). The Company and CFO are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.” RECITAL The Company desires to employ CFO, and CFO is willing

November 4, 2020 EX-10.19

Employment Agreement, effective July 31, 2020, by and between Registrant and Paul Lizzul

ANAPTYSBIO, INC. EMPLOYMENT AGREEMENT This EMPLOYMENT AGREEMENT (this “Agreement”) is made effective from July 31, 2020 (the “Effective Date”) by and among ANAPTYSBIO, INC. (the “Company”) and Paul Lizzul, MD (“CMO”). The Company and CMO are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.” RECITAL The Company desires to employ CMO, and CMO is willin

November 4, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: November 4, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

November 4, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2020 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, IN

November 4, 2020 EX-99.1

AnaptysBio Announces Third Quarter 2020 Financial Results and Provides Pipeline Updates

AnaptysBio Announces Third Quarter 2020 Financial Results and Provides Pipeline Updates •Positive topline data from GALLOP Phase 2 clinical trial of imsidolimab in moderate to severe Generalized Pustular Psoriasis (GPP) announced in October 2020 •FDA end-of-Phase 2 meeting anticipated in Q4 2020 to outline registration path of imsidolimab for the treatment of GPP, in accordance with the orphan dru

November 4, 2020 EX-10.17

Amended and Restated Employment Agreement, effective July 15, 2020, by and between Registrant and Eric Loumeau

ANAPTYSBIO, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (this “Agreement”) is made effective from July 15, 2020 (the “Effective Date”) by and among AnaptysBio, Inc. (the “Company”) and Eric Loumeau (“Executive”). The Company and Executive are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.” This Agre

October 26, 2020 8-K

Entry into a Material Definitive Agreement - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 23, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

October 13, 2020 EX-99

AnaptysBio Reports Positive Topline Data from GALLOP Phase 2 Clinical Trial of Imsidolimab in Moderate-to-Severe Generalized Pustular Psoriasis (GPP)

EX-99 8 gallopgpppressrelease1.htm EX-99 AnaptysBio Reports Positive Topline Data from GALLOP Phase 2 Clinical Trial of Imsidolimab in Moderate-to-Severe Generalized Pustular Psoriasis (GPP) •6 of 8 patients achieved primary endpoint of improvement in the clinical global impression scale (CGI) on Day 29, with rapid reduction of skin pustules by 60% on Day 8 and 94% clearance on Day 29 •FDA end-of-

October 13, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: October 13, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File

August 20, 2020 8-K

Termination of a Material Definitive Agreement - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 20, 2020 ANAPTYSBIO, INC.

August 10, 2020 EX-99.1

AnaptysBio Announces Second Quarter 2020 Financial Results and Provides Pipeline Updates

AnaptysBio Announces Second Quarter 2020 Financial Results and Provides Pipeline Updates •Interim 8-Week Top-Line Data From Etokimab ECLIPSE Phase 2 Trial in Chronic Rhinosinusitis with Nasal Polyps Did Not Demonstrate Statistical Significance For Either Q4W or Q8W Versus Placebo; Company Plans To Assess Path Forward for Etokimab After Complete 16-Week Trial Data by year-end 2020 •Following Orphan

August 10, 2020 EX-99.2

AnaptysBio Reports Top-Line Data from Interim Analysis of ECLIPSE Phase 2 Clinical Trial of Etokimab in Chronic Rhinosinusitis with Nasal Polyps

EX-99.2 3 etokimabcrswnpiapr.htm EXHIBIT 99.2 AnaptysBio Reports Top-Line Data from Interim Analysis of ECLIPSE Phase 2 Clinical Trial of Etokimab in Chronic Rhinosinusitis with Nasal Polyps –Etokimab q4w and q8w treatment arms failed to achieve NPS and SNOT-22 statistical significance over placebo at this week 8 interim analysis –Secondary analyses demonstrated NPS and blood eosinophil level impr

August 10, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: August 10, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File N

August 10, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2020 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (E

July 31, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: July 20, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

July 31, 2020 EX-99.01

AnaptysBio Appoints Dr. Paul F. Lizzul As Chief Medical Officer Dermatology Physician-Scientist To Lead Wholly-Owned Pipeline Advancement

AnaptysBio Appoints Dr. Paul F. Lizzul As Chief Medical Officer Dermatology Physician-Scientist To Lead Wholly-Owned Pipeline Advancement SAN DIEGO, July 31st, 2020 - AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company developing first-in-class antibody product candidates focused on emerging immune control mechanisms applicable to inflammation and immuno-oncology indications, t

July 15, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: July 13, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

July 15, 2020 EX-99.01

AnaptysBio Expands Executive Leadership Team Appoints Dennis Mulroy as Chief Financial Officer and Eric Loumeau as Chief Operating Officer

AnaptysBio Expands Executive Leadership Team Appoints Dennis Mulroy as Chief Financial Officer and Eric Loumeau as Chief Operating Officer SAN DIEGO, July 15, 2020 - AnaptysBio, Inc.

June 19, 2020 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: June 19, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Num

May 6, 2020 EX-10.16

Wateridge Lease Agreement.

LEASE AGREEMENT BETWEEN WATERIDGE PROPERTY OWNER, LP, a Delaware limited partnership (LANDLORD) AND ANAPTYSBIO, INC.

May 6, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report: May 6, 2020 (Date of earliest event reported) ANAPTYSBIO, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37985 20-3828755 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

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