PLRX / Pliant Therapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Pliant Therapeutics, Inc.
US ˙ NasdaqGS ˙ US7291391057

Mga Batayang Estadistika
LEI 5493002Q5LITR7VHZH02
CIK 1746473
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Pliant Therapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2025 PLIANT THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissio

August 7, 2025 EX-10.1

Form of Retention Agreement

Pliant Therapeutics, Inc. Retention Agreement [Date] [Name] Dear [Name], In consideration of the activities necessary for Pliant Therapeutics, Inc. (“Company”) to support critical programs, the Company is offering you a cash retention award in an amount equal to [●] (the “Retention Award”). The Retention Award is subject to the terms and conditions provided below. The Retention Award will vest on

August 7, 2025 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2025 Financial Results BEACON-IPF close out activities continue Previously announced workforce and operational realignment largely complete Phase 1 oncology trial on track to de

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2025 Financial Results BEACON-IPF close out activities continue Previously announced workforce and operational realignment largely complete Phase 1 oncology trial on track to deliver additional data by the end of the year SOUTH SAN FRANCISCO, CA., August 7, 2025 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clini

August 7, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC

June 9, 2025 EX-3.1

, as currently in effect (incorporated by reference to Exhibit 3.1 of the Registrant's Current Report on Form 8-K (File No. 001-39303) filed on June 9, 2025

CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PLIANT THERAPEUTICS, INC.

June 9, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2025 PLIANT THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 8, 2025 EX-10.1

Amended and Restated Non-Employee Director Compensation Policy

PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or officers of the Company

May 8, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission F

May 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, IN

May 8, 2025 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2025 Financial Results Activities supporting the close out of BEACON-IPF continue; topline data expected in the second quarter of 2025 Recently announced strategic realignment of

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2025 Financial Results Activities supporting the close out of BEACON-IPF continue; topline data expected in the second quarter of 2025 Recently announced strategic realignment of workforce and operations will extend cash runway to support execution of late-stage clinical trials SOUTH SAN FRANCISCO, CA., May 8, 202

May 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2025 PLIANT THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission F

April 23, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confi

April 23, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101)   INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use

April 11, 2025 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a

April 10, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confi

March 13, 2025 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 PLIANT THERAPEUTICS, INC. (Exact name of Regi

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) Delaware 47-4272481 (State or other jurisdiction of incorporation or organization) (IRS Employer Identification No

March 13, 2025 EX-4.1

Stockholder Rights Agreement, dated as of March 12, 2025, by and between the Company and Computershare Trust Company, N.A., as rights agent (which includes the Form of Rights Certificate as Exhibit B thereto) (incorporated by reference to Exhibit 4.1 to the Company’s Registration Statement on Form 8-A, filed with the Securities and Exchange Commission on March 13, 2025, File No. 001-39303)

EX-4.1 Exhibit 4.1 STOCKHOLDER RIGHTS AGREEMENT Pliant Therapeutics, Inc. and Computershare Trust Company, N.A., as Rights Agent Dated as of March 12, 2025 Table of Contents Page Section 1. Certain Definitions 1 Section 2. Appointment of Rights Agent 10 Section 3. Issuance of Rights Certificates 10 Section 4. Form of Rights Certificates 12 Section 5. Countersignature and Registration 13 Section 6.

March 13, 2025 EX-99.1

Pliant Therapeutics Adopts Limited Duration Stockholder Rights Agreement

EX-99.1 Exhibit 99.1 Pliant Therapeutics Adopts Limited Duration Stockholder Rights Agreement South San Francisco, CA—March 13, 2025 – Pliant Therapeutics, Inc. (Nasdaq: PLRX) today announced that its Board of Directors has unanimously adopted a limited duration stockholder rights agreement (the “Rights Agreement”) to protect stockholder interests. The Board resolved to adopt the Rights Agreement

March 13, 2025 EX-3.1

Certificate of Designation of Series A Junior Participating Preferred Stock (incorporated by reference to Exhibit 3.1 of the

Exhibit 3.1 CERTIFICATE OF DESIGNATION OF SERIES A JUNIOR PARTICIPATING PREFERRED STOCK OF PLIANT THERAPEUTICS, INC. Pursuant to Section 151 of the General Corporation Law of the State of Delaware The undersigned hereby certifies that the following resolution was duly adopted by the board of directors of Pliant Therapeutics, Inc., a Delaware corporation (the “Corporation”), on March 12, 2025: RESO

March 13, 2025 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 12, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissio

March 3, 2025 EX-19.1

Insider Trading

PLIANT THERAPEUTICS, INC. INSIDER TRADING COMPLIANCE POLICY Pliant Therapeutics, Inc., a Delaware corporation (the “Company”) prohibits: •insider trading in the Company’s securities or stock (collectively, “Securities”); and •the unauthorized disclosure of the Company’s confidential information that might enable others to engage in insider trading in the Securities. The Company designed this Insid

March 3, 2025 EX-10.19

Amended and Restated Non-Employee Director Compensation Policy

PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or officers of the Company

March 3, 2025 EX-10.14

2022 Inducement Plan dated September 14, 2022.

PLIANT THERAPEUTICS, INC. 2022 INDUCEMENT PLAN 1.PURPOSE OF PLAN The purpose of this Pliant Therapeutics, Inc. 2022 Inducement Plan (this “Plan”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company by providing a material inducement for the best available individuals to join the Company and its Subsidiaries as employees by affording such

March 3, 2025 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 PLIANT THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Its Charter)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PLIANT THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 47-4272481 (State or Other Jurisdiction of Incorporation) (IRS Employer Identification No.) 331 Oyster Point Boulevard South San Francisco, CA 94080 (Address of Principal Ex

March 3, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2025 PLIANT THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

March 3, 2025 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2024 Financial Results Discontinuation of BEACON-IPF following DSMB and outside expert panel recommendation

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2024 Financial Results Discontinuation of BEACON-IPF following DSMB and outside expert panel recommendation SOUTH SAN FRANCISCO, CA., March 3, 2025 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment

March 3, 2025 EX-FILING FEES

Calculation of Filing Fee Table

Calculation of Filing Fee Tables S-8 PLIANT THERAPEUTICS, INC. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee 1 Equity Common Stock, par value $0.0001 per share Other 3,043,047 $ 3.08 $ 9,372,584.76 0.0001531 $ 1,434.94 2 Equi

March 3, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-393

February 13, 2025 EX-99.1

Pliant Therapeutics Announces Next Steps Following DSMB Recommendation on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis Pliant has initiated assembly of outside panel of world-renowned experts to review BEACON-IPF tria

Exhibit 99.1 Pliant Therapeutics Announces Next Steps Following DSMB Recommendation on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis Pliant has initiated assembly of outside panel of world-renowned experts to review BEACON-IPF trial data SOUTH SAN FRANCISCO, CA., February 13, 2025 - Pliant Therapeutics, Inc. (Nasdaq: PLRX) today announced that, per the charter of th

February 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2025 PLIANT THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commis

February 10, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 7, 2025 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

February 10, 2025 EX-99.1

Pliant Therapeutics Provides Update on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis Following DSMB recommendation, the Company has voluntarily paused enrollment and dosing in the BEACON-IPF Phase 2b trial and will mon

Exhibit 99.1 Pliant Therapeutics Provides Update on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis Following DSMB recommendation, the Company has voluntarily paused enrollment and dosing in the BEACON-IPF Phase 2b trial and will monitor current patients while data is reviewed SOUTH SAN FRANCISCO, CA., February 7, 2025 - Pliant Therapeutics, Inc. (Nasdaq: PLRX) today

November 14, 2024 EX-99.1

Joint Filing Agreement

EX-99.1 2 tm2427858d7ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the “Schedule 13G”) relating to the Common Stock, par valu

November 14, 2024 EX-99.A

JOINT FILING AGREEMENT

EX-99.A 2 ex99-a.htm JOINT FILING AGREEMENT CUSIP No . 729139105 Page 7 of 7 Exhibit A JOINT FILING AGREEMENT The Undersigned agree that the statement on Schedule 13G with respect to the common stock of Pliant Therapeutics, Inc, dated as of November 14, 2024, is, and any amendment thereto signed by each of the undersigned shall be, filed on behalf of each of them pursuant to and in accordance with

November 14, 2024 SC 13G/A

PLRX / Pliant Therapeutics, Inc. / Blue Owl Capital Holdings LP - SC 13G/A Passive Investment

SC 13G/A 1 ef20038687sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 729139 105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Stateme

November 14, 2024 SC 13G

PLRX / Pliant Therapeutics, Inc. / Redmile Group, LLC - SC 13G Passive Investment

SC 13G 1 tm2427858d7sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ) Pliant therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Che

November 14, 2024 SC 13G/A

PLRX / Pliant Therapeutics, Inc. / First Light Asset Management, LLC - AMENDMENT TO FORM SC 13G Passive Investment

SC 13G/A 1 plrx-sc13ga093024.htm AMENDMENT TO FORM SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* (Amendment) Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 729139105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement

November 12, 2024 SC 13G/A

PLRX / Pliant Therapeutics, Inc. / Laurion Capital Management LP - LAURION CAPITAL MANAGEMENT LP Passive Investment

SC 13G/A 1 plrxa1111224.htm LAURION CAPITAL MANAGEMENT LP UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139105 (CUSIP Number) September 30, 2024 (Date of Event which Requires Filing

November 7, 2024 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2024 Financial Results BEACON-IPF Phase 2b trial on track for full enrollment in the first quarter of 2025 with data anticipated in mid-2026

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2024 Financial Results BEACON-IPF Phase 2b trial on track for full enrollment in the first quarter of 2025 with data anticipated in mid-2026 SOUTH SAN FRANCISCO, CA., November 7, 2024 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a late-stage clinical biotechnology company and leader in the discovery and development

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS

November 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

October 4, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 tm2424913d1ex1.htm EXHIBIT 1 Exhibit 1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock, $0.0001 par value per share, of Pliant Therapeutics, Inc., and furth

October 4, 2024 SC 13G

PLRX / Pliant Therapeutics, Inc. / Paradigm Biocapital Advisors LP - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 729139105 (CUSIP Number) September 24, 2024 (Date of Event Which Requires Filing of this statement) Check the appropriate box to designate

September 27, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 24, 2024 PLIANT THERAPE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 24, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commi

September 27, 2024 EX-3.1

Amended and Restated Bylaws of the Registrant, as currently in effect (Incorporated by reference to Exhibit 3.1 of the Registrant’s current report on Form 8-K filed on September

THIRD AMENDED AND RESTATED BYLAWS OF PLIANT THERAPEUTICS, INC. (the “Corporation”) TABLE OF CONTENTS Page SECTION 1. Annual Meeting 1 SECTION 2. Notice of Stockholder Business and Nominations. 1 SECTION 3. Special Meetings 11 SECTION 4. Notice of Meetings; Adjournments. 12 SECTION 5. Quorum 13 SECTION 6. Voting and Proxies 13 SECTION 7. Action at Meeting 13 SECTION 8. Stockholder Lists 14 SECTION

August 7, 2024 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2024 Financial Results Positive data from a 12-week Phase 2a PET imaging trial demonstrated reduced total lung collagen, improved FVC and reduced cough severity in IPF patients

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2024 Financial Results Positive data from a 12-week Phase 2a PET imaging trial demonstrated reduced total lung collagen, improved FVC and reduced cough severity in IPF patients treated with bexotegrast Positive long-term data from INTEGRIS-PSC 320 mg dose group demonstrated bexotegrast was well tolerated with con

August 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC

August 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissio

July 15, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

July 15, 2024 EX-99.1

Pliant Therapeutics Announces Positive Long-Term Data from the INTEGRIS-PSC Phase 2a Trial Demonstrating Bexotegrast was Well Tolerated at 320 mg with Continued Antifibrotic and Anti-Cholestatic Activity Displayed Across Multiple Measures Bexotegrast

Exhibit 99.1 Pliant Therapeutics Announces Positive Long-Term Data from the INTEGRIS-PSC Phase 2a Trial Demonstrating Bexotegrast was Well Tolerated at 320 mg with Continued Antifibrotic and Anti-Cholestatic Activity Displayed Across Multiple Measures Bexotegrast at 320 mg was well tolerated up to 40 weeks of treatment with no treatment-related severe or serious adverse events 320 mg cohort demons

June 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 PLIANT THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 14, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 14, 2024 EX-99.1

Pliant Therapeutics Announces Positive Topline Data from a Phase 2a Collagen PET Imaging Clinical Trial of Bexotegrast in Patients with Idiopathic Pulmonary Fibrosis 12-week treatment with Bexotegrast 160 mg resulted in reduction of total lung collag

EX-99.1 Exhibit 99.1 Pliant Therapeutics Announces Positive Topline Data from a Phase 2a Collagen PET Imaging Clinical Trial of Bexotegrast in Patients with Idiopathic Pulmonary Fibrosis 12-week treatment with Bexotegrast 160 mg resulted in reduction of total lung collagen as measured by PET imaging, compared to an increase on placebo Improvement in FVC and reduction in cough severity reported in

May 6, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission F

May 6, 2024 EX-10.3

Amended and Restated Loan and Security Agreement, by and among the Registrant, the lenders from time to time party thereto and Oxford Finance LLC, dated March 11, 2024

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (as the same may from time to time be amended, restated, amended and restated, supplemented or otherwise modified from time to time, this “Agreement”) dated as of March 11, 2024 (the “Effective Date”) among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314 (“Oxford”), as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.

May 6, 2024 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2024 Financial Results BEACON-IPF pivotal, adaptive Phase 2b/3 trial design implementation significantly accelerates bexotegrast development in IPF Data from completed 12 week Ph

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2024 Financial Results BEACON-IPF pivotal, adaptive Phase 2b/3 trial design implementation significantly accelerates bexotegrast development in IPF Data from completed 12 week Phase 2a imaging trial measuring bexotegrast’s effect on total lung collagen and FVC in IPF patients expected in the coming weeks Regulator

May 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, IN

April 22, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101)   INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use

April 22, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confi

March 12, 2024 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 11, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission Fi

March 12, 2024 EX-99.1

Pliant Therapeutics Announces Accelerated Bexotegrast Development Plan for the Treatment of Idiopathic Pulmonary Fibrosis Acceptance by European Union and other global health authorities of the pivotal, adaptive Phase 2b/3 trial will significantly sh

Exhibit 99.1 Pliant Therapeutics Announces Accelerated Bexotegrast Development Plan for the Treatment of Idiopathic Pulmonary Fibrosis Acceptance by European Union and other global health authorities of the pivotal, adaptive Phase 2b/3 trial will significantly shorten bexotegrast’s time to Phase 3 data Upsized Oxford Finance debt facility extends cash runway and funds accelerated development throu

February 27, 2024 EX-97

Clawback Policy

PLIANT THERAPEUTICS, INC. POLICY ON RECOUPMENT AND FORFEITURE OF INCENTIVE COMPENSATION Adopted September 21, 2023 Overview The Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) of Pliant Therapeutics, Inc. (the “Company”) believes it is prudent to create and maintain a culture that emphasizes integrity and accountability and that reinforces the Company’s pay-for-per

February 27, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-393

February 27, 2024 EX-FILING FEES

Calculation of Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table FORM S-8 (Form Type) Pliant Therapeutics, Inc.

February 27, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2024 PLIANT THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commis

February 27, 2024 EX-10.17

Amended and Restated Non-Employee Director Compensation Policy

PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or officers of the Company

February 27, 2024 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 PLIANT THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Its Charter)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PLIANT THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 47-4272481 (State or Other Jurisdiction of Incorporation) (IRS Employer Identification No.) 260 Littlefield Avenue, South San Francisco, CA 94080 (Address of Principal Execu

February 27, 2024 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2023 Financial Results Positive interim 12-week safety and efficacy data reported from Phase 2a INTEGRIS-PSC trial in patients with PSC Enrollment continues in BEACON-IPF, a Pha

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2023 Financial Results Positive interim 12-week safety and efficacy data reported from Phase 2a INTEGRIS-PSC trial in patients with PSC Enrollment continues in BEACON-IPF, a Phase 2b trial in patients with IPF SOUTH SAN FRANCISCO, CA., February 27, 2024 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage

February 14, 2024 SC 13G

PLRX / Pliant Therapeutics, Inc. / Blue Owl Capital Holdings LP - SC 13G Passive Investment

SC 13G 1 ef20021763sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 729139 105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Che

February 14, 2024 SC 13G/A

PLRX / Pliant Therapeutics, Inc. / Redmile Group, LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm245846d8sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4) Pliant therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement)

February 14, 2024 SC 13G

PLRX / Pliant Therapeutics, Inc. / First Light Asset Management, LLC - ACQUISITION OF BENEFICIAL OWNERSHIP Passive Investment

SC 13G 1 plrxsc13g-123123.htm ACQUISITION OF BENEFICIAL OWNERSHIP UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Che

February 14, 2024 SC 13G/A

PLRX / Pliant Therapeutics, Inc. / Third Rock Ventures III, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 d787653dsc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* Pliant Therapeutics, Inc. (Name of Issuer) COMMON STOCK, $0.0001 PAR VALUE PER SHARE (Title of Class of Securities) 729139 105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement)

February 14, 2024 SC 13G/A

PLRX / Pliant Therapeutics, Inc. / Deep Track Capital, LP Passive Investment

SC 13G/A 1 deeptrack-plrx123123a1.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* PLIANT THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) C

February 14, 2024 EX-99.1

Joint Filing Agreement

EX-99.1 2 tm245846d8ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the “Schedule 13G”) relating to the Common Stock, par value

February 13, 2024 SC 13G

PLRX / Pliant Therapeutics, Inc. / VANGUARD GROUP INC - SCHEDULE 13G Passive Investment

SC 13G 1 tv01713-plianttherapeuticsin.htm SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 Name of issuer: Pliant Therapeutics Inc Title of Class of Securities: Common Stock CUSIP Number: 729139105 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to designate the rule purs

February 8, 2024 SC 13G

PLRX / Pliant Therapeutics, Inc. / Laurion Capital Management LP Passive Investment

SC 13G 1 laurion-plrx123123.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* PLIANT THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the

February 5, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 4, 2024 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

February 5, 2024 EX-99.1

Pliant Therapeutics Announces Positive Safety and Exploratory Efficacy Data from the INTEGRIS-PSC Phase 2a Trial of Bexotegrast 320 mg in Patients with Primary Sclerosing Cholangitis and Suspected Liver Fibrosis Bexotegrast (PLN-74809) at 320 mg was

Exhibit 99.1 Pliant Therapeutics Announces Positive Safety and Exploratory Efficacy Data from the INTEGRIS-PSC Phase 2a Trial of Bexotegrast 320 mg in Patients with Primary Sclerosing Cholangitis and Suspected Liver Fibrosis Bexotegrast (PLN-74809) at 320 mg was well tolerated over 12 weeks of treatment with no drug-related severe or serious adverse events; No safety concerns identified across all

November 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 PLIANT THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS

November 9, 2023 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2023 Financial Results Positive interim 12-week safety and efficacy data reported from Phase 2a INTEGRIS-PSC trial in patients with PSC Positive DSMB safety review recommends INT

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2023 Financial Results Positive interim 12-week safety and efficacy data reported from Phase 2a INTEGRIS-PSC trial in patients with PSC Positive DSMB safety review recommends INTEGRIS-PSC trial continue without modification Key Clinical Development and Regulatory appointments expand leadership team SOUTH SAN FRANC

October 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2023 PLIANT THERAPE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commi

October 3, 2023 EX-10.1

Lease Agreement by and between the Registrant and HCP BTC, LLC, dated September 28, 2023.

BRITANNIA OYSTER POINT LEASE This Lease (the "Lease"), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the "Summary"), below, is made by and between HCP BTC, LLC, a Delaware limited liability company ("Landlord"), and PLIANT THERAPEUTICS, INC.

October 3, 2023 EX-10.2

Termination Agreement by and between the Registrant and Healthpeak OP, LLC, dated September 28, 2023.(incorporated herein by reference to Exhibit 10.2 of the Registrant's Current Report on Form 8-K (File No. 001-39303) filed on October 3, 2023.)

TERMINATION AGREEMENT This Termination Agreement (this "Agreement") is entered into as of September 28 , 2023, by and between HEALTHPEAK OP, LLC, a Maryland limited liability company (successor-interest to HCP, Inc.

September 26, 2023 EX-99.1

Pliant Therapeutics Announces Positive Safety and Exploratory Efficacy Data from Phase 2a INTEGRIS-PSC Clinical Trial of Bexotegrast in Patients with Primary Sclerosing Cholangitis and Suspected Liver Fibrosis Bexotegrast (PLN-74809) was well tolerat

Exhibit 99.1 Pliant Therapeutics Announces Positive Safety and Exploratory Efficacy Data from Phase 2a INTEGRIS-PSC Clinical Trial of Bexotegrast in Patients with Primary Sclerosing Cholangitis and Suspected Liver Fibrosis Bexotegrast (PLN-74809) was well tolerated over 12 weeks of treatment with few discontinuations and no drug-related severe or serious adverse events Bexotegrast reduced both the

September 26, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commi

August 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 PLIANT THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissio

August 9, 2023 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2023 Financial Results Initiation of Phase 2b BEACON-IPF trial of bexotegrast in patients with IPF INTEGRIS-PSC Phase 2a 12-week data of bexotegrast in patients with PSC expecte

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2023 Financial Results Initiation of Phase 2b BEACON-IPF trial of bexotegrast in patients with IPF INTEGRIS-PSC Phase 2a 12-week data of bexotegrast in patients with PSC expected in the third quarter of 2023 Initiation of Phase 1 trial of PLN-101095 in patients with solid tumors resistant to checkpoint inhibitors

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC

June 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2023 PLIANT THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 9, 2023 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2023 Financial Results Positive long-term data from INTEGRIS-IPF 320 mg dose group at 24-weeks demonstrated bexotegrast was well tolerated with durable improvement shown across m

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2023 Financial Results Positive long-term data from INTEGRIS-IPF 320 mg dose group at 24-weeks demonstrated bexotegrast was well tolerated with durable improvement shown across multiple measures INTEGRIS-PSC 12-week data expected in the third quarter of 2023 BEACON-IPF Phase 2b trial initiation expected in mid-202

May 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, IN

May 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023. PLIANT THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2023 PLIANT THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissio

May 1, 2023 EX-99.1

Pliant Therapeutics Announces Positive Long-Term Data from the INTEGRIS-IPF Phase 2a Trial Demonstrating Bexotegrast was Well Tolerated at 320 mg with Durable Improvement Shown in FVC and Across Multiple Measures Bexotegrast was well tolerated up to

EX-99.1 Exhibit 99.1 Pliant Therapeutics Announces Positive Long-Term Data from the INTEGRIS-IPF Phase 2a Trial Demonstrating Bexotegrast was Well Tolerated at 320 mg with Durable Improvement Shown in FVC and Across Multiple Measures Bexotegrast was well tolerated up to 40 weeks of treatment with no drug-related serious adverse events Combination of bexotegrast with standard of care reduced FVC de

April 27, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101)   INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use

April 26, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confi

March 27, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pliant Therapeutics, Inc.

March 27, 2023 S-3ASR

As filed with the Securities and Exchange Commission on March 27, 2023

Table of Contents As filed with the Securities and Exchange Commission on March 27, 2023 Registration No.

March 20, 2023 SC 13G

PLRX / Pliant Therapeutics Inc / Deep Track Capital, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

March 9, 2023 10-K

Form 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-393

March 9, 2023 EX-FILING FEES

Calculation of Filing Fee Table

EX-FILING FEES EXHIBIT 107 Calculation of Filing Fee Table FORM S-8 (Form Type) Pliant Therapeutics, Inc.

March 9, 2023 EX-10.19

First Amendment to Loan and Security Agreement, by and between Registrant and Oxford Finance LLC, dated October 4, 2022.

firstamendmenttoloanands EAST\196098002.6 FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into as of October 4, 2022, by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314 (“Oxford”), as collateral agent (in such capacity

March 9, 2023 EX-10.16

First Amendment to Collaboration and License Agreement, by and between the Registrant and Novartis Institutes For Biomedical Research, Inc., dated November 15, 2022.

firstamendmenttocollabor DocuSign Envelope ID: 65968F64-E079-45BD-8FC2-229D077252F8 EXECUTION COPY CONFIDENTIAL Page 1 of 6 FIRST AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT This First Amendment to Collaboration and License Agreement (the “First Amendment”) is entered into as of November 15, 2022 (the “Amendment Effective Date”), by and between Pliant Therapeutics, Inc.

March 9, 2023 EX-10.20

Amended and Restated Non-Employee Director Compensation Policy

non-employeedirectorcomp ACTIVE/106239414.4 PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who a

March 9, 2023 EX-10.17

2022 Inducement Plan dated September 14, 2022.

a2022inducementplan PLIANT THERAPEUTICS, INC. 2022 INDUCEMENT PLAN 1. PURPOSE OF PLAN The purpose of this Pliant Therapeutics, Inc. 2022 Inducement Plan (this “Plan”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company by providing a material inducement for the best available individuals to join the Company and its Subsidiaries as employ

March 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 PLIANT THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

March 9, 2023 EX-10.21

Offer Letter, by and between the Registrant and Lily Cheung, dated December 21, 2022.

offerletter-lilycheung December 21, 2022 Dear Lily: We are very pleased to offer you the position of Chief Human Resources Officer, at Pliant Therapeutics, Inc.

March 9, 2023 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2022 Financial Results –Positive data from bexotegrast INTEGRIS-IPF 320 mg dose group demonstrated a continued favorable safety profile and statistically significant increases i

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2022 Financial Results –Positive data from bexotegrast INTEGRIS-IPF 320 mg dose group demonstrated a continued favorable safety profile and statistically significant increases in FVC –INTEGRIS-IPF 320 mg dose 24-week data expected in the second quarter of 2023 –$287.5 million equity financing extends runway into

March 9, 2023 S-8

As filed with the Securities and Exchange Commission on March 9, 2023

As filed with the Securities and Exchange Commission on March 9, 2023 Registration No.

March 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 6, 2023 PLIANT THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 6, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

February 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 17, 2023 PLIANT THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 17, 2023 PLIANT THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

February 14, 2023 SC 13G/A

PLRX / Pliant Therapeutics Inc / Third Rock Ventures III, L.P. - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Pliant Therapeutics, Inc. (Name of Issuer) COMMON STOCK, $0.0001 PAR VALUE PER SHARE (Title of Class of Securities) 729139 105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to

February 14, 2023 EX-99.1

Joint Filing Agreement

EX-99.1 2 tm236041d16ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the “Schedule 13G”) relating to the Common Stock, $0.0001

February 14, 2023 SC 13G/A

PLRX / Pliant Therapeutics Inc / Redmile Group, LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm236041d16sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3) Pliant therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check th

February 13, 2023 SC 13G/A

PLRX / Pliant Therapeutics Inc / CHI Advisors LLC - CHI ADVISORS LLC Passive Investment

SC 13G/A 1 plrxa221323.htm CHI ADVISORS LLC UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statem

January 25, 2023 EX-1.1

Underwriting Agreement, dated as of January 24, 2023, by and among Pliant Therapeutics, Inc. and J.P. Morgan Securities LLC and Piper Sandler & Co., as representatives of the several underwriters named therein.

EX-1.1 2 d455919dex11.htm EX-1.1 Exhibit 1.1 EXECUTION VERSION Pliant Therapeutics, Inc. 8,333,334 Shares Common Stock (par value $0.0001 per share) Underwriting Agreement New York, New York January 24, 2023 J.P. Morgan Securities LLC Piper Sandler & Co. As Representatives of the several Underwriters c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 c/o Piper Sandler & Co.

January 25, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

January 25, 2023 424B5

Joint book-running managers J.P. Morgan Piper Sandler RBC Capital Markets Lead managers Cantor Oppenheimer & Co. H.C. Wainwright & Co.

424B5 1 d425201d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-257684 and 333-269397 Prospectus supplement (To prospectus dated July 11, 2022) 8,333,334 shares Common stock We are offering 8,333,334 shares of our common stock. Our common stock is listed on the Nasdaq Global Select Market under the symbol “PLRX”. On January 24, 2023, the last reported sale

January 24, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pliant Therapeutics, Inc.

January 24, 2023 S-3MEF

As filed with the Securities and Exchange Commission on January 24, 2023

As filed with the Securities and Exchange Commission on January 24, 2023 Registration No.

January 23, 2023 EX-99.1

Pliant Therapeutics Announces Positive Data from the INTEGRIS-IPF Phase 2a Trial Demonstrating Bexotegrast 320 mg was Well Tolerated and Achieved Statistically Significant FVC Increase in Patients with Idiopathic Pulmonary Fibrosis Bexotegrast demons

EX-99.1 Exhibit 99.1 Pliant Therapeutics Announces Positive Data from the INTEGRIS-IPF Phase 2a Trial Demonstrating Bexotegrast 320 mg was Well Tolerated and Achieved Statistically Significant FVC Increase in Patients with Idiopathic Pulmonary Fibrosis Bexotegrast demonstrated statistically significant increase in FVC at 4, 8 and 12 weeks of treatment, outperforming lower dose groups No bexotegras

January 23, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

January 23, 2023 424B5

Subject to completion, dated January 23, 2023

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-257684 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

January 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 22, 2023 PLIANT THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 22, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

January 9, 2023 EX-99.1

Disclaimers This presentation has been prepared by Pliant Therapeutics, Inc. ( we, us, our, Pliant or the “Company”). The information set forth herein does not purport to be complete or to contain all of the information you may desire. Statements con

EX-99.1 2 d406540dex991.htm EX-99.1 Exhibit 99.1 Developing Novel Treatments for Fibrotic Diseases JANUARY 2023 © 2023 PLIANT THERAPEUTICS Disclaimers This presentation has been prepared by Pliant Therapeutics, Inc. ( we, us, our, Pliant or the “Company”). The information set forth herein does not purport to be complete or to contain all of the information you may desire. Statements contained here

January 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 PLIANT THERAPEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissi

November 18, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 16, 2022 PLIANT THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 16, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commis

November 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2022. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commis

November 8, 2022 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2022 Financial Results

EX-99.1 2 a3q2022exhibit991.htm EX-99.1 Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2022 Financial Results SOUTH SAN FRANCISCO, CA., November 8, 2022 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS

September 16, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 14, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commi

September 16, 2022 EX-3.1

Amended and Restated Bylaws of the Registrant, as currently in effect.

Exhibit 3.1 SECOND AMENDED AND RESTATED BYLAWS OF PLIANT THERAPEUTICS, INC. (the ?Corporation?) ARTICLE I Stockholders SECTION 1. Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these Bylaws as an ?Annual Meeting?) shall be held at the hour, date and place within or without the United States which is fixed by the Board of Directors, which time, date and pl

August 31, 2022 SC 13G/A

PLRX / Pliant Therapeutics Inc / Novartis Institutes for BioMedical Research, Inc. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139 105 (CUSIP Number) August 8, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate th

August 31, 2022 EX-99.2

EVIDENCE OF SIGNATORY AUTHORITY

EXHIBIT 99.2 EVIDENCE OF SIGNATORY AUTHORITY Excerpt from Commercial Register of Novartis AG Identification number Legal status Entry Cancelled 1 CHE-103.867.266 Limited or Corporation 01.03.1996 All data In Ca Business name Ref Legal seat 1 Novartis AG 1 Basel 1 (Novartis SA) (Novartis Inc.) CHE-103.867.266 Novartis AG Basel 1 All data In Mo Ca Personal Data Function Signature 8 Retzler, Dr. Char

August 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC

August 8, 2022 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2022 Financial Results

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2022 Financial Results SOUTH SAN FRANCISCO, CA., August 8, 2022 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and reported second quarter 2022 financial re

August 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2022. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissi

July 14, 2022 424B5

Joint book-running managers J.P. Morgan Cowen RBC Capital Markets Lead managers Cantor BTIG

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-257684 Prospectus supplement (To prospectus dated July 11, 2022) 10,810,811 shares Common stock We are offering 10,810,811 shares of our common stock. Our common stock is listed on the Nasdaq Global Select Market under the symbol ?PLRX?. On July 12, 2022, the last reported sale price of our common stock on the Nasdaq Global Se

July 14, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 11, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

July 14, 2022 EX-1.1

Underwriting Agreement, dated as of July 12, 2022, by and among Pliant Therapeutics, Inc. and J.P. Morgan Securities LLC and Cowen and Company, LLC, as representatives of the several underwriters named therein.

Exhibit 1.1 EXECUTION VERSION Pliant Therapeutics, Inc. 10,810,811 Shares Common Stock ($0.0001 par value) Underwriting Agreement New York, New York July 12, 2022 J.P. Morgan Securities LLC Cowen and Company, LLC As Representatives of the several Underwriters c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 c/o Cowen and Company, LLC 599 Lexington Avenue New York, New Yor

July 11, 2022 POS EX

As filed with the Securities and Exchange Commission on July 11, 2022

As filed with the Securities and Exchange Commission on July 11, 2022 Registration No.

July 11, 2022 424B5

Joint book-running managers J.P. Morgan Cowen RBC Capital Markets Lead managers Cantor BTIG

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-257684 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

July 11, 2022 EX-99.1

Pliant Therapeutics Announces Positive Safety and Efficacy Data from Phase 2a INTEGRIS-IPF Clinical Trial of PLN-74809 in Patients with Idiopathic Pulmonary Fibrosis PLN-74809 demonstrated a dose-dependent treatment effect on FVC and QLF versus place

Exhibit 99.1 Pliant Therapeutics Announces Positive Safety and Efficacy Data from Phase 2a INTEGRIS-IPF Clinical Trial of PLN-74809 in Patients with Idiopathic Pulmonary Fibrosis PLN-74809 demonstrated a dose-dependent treatment effect on FVC and QLF versus placebo over 12 weeks of treatment PLN-74809 treatment effect was observed on top of standard of care therapy and as monotherapy PLN-74809 was

July 11, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 10, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

June 17, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 27, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 2) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ☐ T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 2) (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-3

May 27, 2022 CORRESP

Sidley Austin (CA) LLP is a Delaware limited liability partnership doing business as Sidley Austin LLP and practicing in affiliation with other Sidley Austin partnerships.

SIDLEY AUSTIN LLP 555 CALIFORNIA STREET SUITE 2000 SAN FRANCISCO, CA 94104 +1 415 772 1200 +1 415 772 7400 FAX AMERICA ? ASIA PACIFIC ? EUROPE +1 415 772 1207 CFLEMING@SIDLEY.

May 9, 2022 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2022 Financial Results $100 million Oxford loan facility extends cash runway to mid-2024 FDA Fast Track designation granted to PLN-74809 in IPF INTEGRIS-IPF Phase 2a data readout

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2022 Financial Results $100 million Oxford loan facility extends cash runway to mid-2024 FDA Fast Track designation granted to PLN-74809 in IPF INTEGRIS-IPF Phase 2a data readout in mid-2022 EMA Orphan Drug designation granted to PLN-74809 in PSC SOUTH SAN FRANCISCO, CA., May 9, 2022 - Pliant Therapeutics, Inc. (N

May 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2022. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, IN

May 5, 2022 EX-10.1

Loan and Security Agreement, by and between Registrant and Oxford Finance LLC, dated May 4, 2022.

Exhibit 10.1 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (as the same may from time to time be amended, restated, amended and restated, supplemented or otherwise modified from time to time, this ?Agreement?) dated as of May 4, 2022 (the ?Effective Date?) among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alex

May 5, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission F

April 29, 2022 DEF 14A

Schedule 14A

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? ? ? Filed by a Party other than the Registrant ??? Check the appropriate box: ?? Preliminary Proxy Statement ?

April 29, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ?? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use o

March 1, 2022 8-K/A

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2022. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of I

March 1, 2022 EX-FILING FEES

Calculation of Registration Fee

EXHIBIT 107 Calculation of Filing Fee Table FORM S-8 (Form Type) Pliant Therapeutics, Inc.

March 1, 2022 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2021 Financial Results

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2021 Financial Results SOUTH SAN FRANCISCO, CA., February 28, 2022 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and reported fourth quarter

March 1, 2022 POS AM

As filed with the Securities and Exchange Commission on March 1, 2022

Table of Contents As filed with the Securities and Exchange Commission on March 1, 2022 Registration No.

March 1, 2022 10-K

Form 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-393

March 1, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-3

March 1, 2022 EX-10.16#

Amended and Restated Non-Employee Director Compensation Policy

PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the ?Policy?) of Pliant Therapeutics, Inc., a Delaware corporation (the ?Company?), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or officers of the Company

March 1, 2022 S-8

As filed with the Securities and Exchange Commission on March 1, 2022

As filed with the Securities and Exchange Commission on March 1, 2022 Registration No.

February 28, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2022. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commi

February 28, 2022 POSASR

As filed with the Securities and Exchange Commission on February 28, 2022

Table of Contents As filed with the Securities and Exchange Commission on February 28, 2022 Registration No.

February 28, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Post-Effective Amendment on Form S-3 (Form Type) Pliant Therapeutics, Inc.

February 28, 2022 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2021 Financial Results

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2021 Financial Results SOUTH SAN FRANCISCO, CA., February 28, 2022 - Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and reported fourth quarter

February 14, 2022 SC 13G/A

PLRX / Pliant Therapeutics Inc / EVENTIDE ASSET MANAGEMENT, LLC - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Pliant Therapeutics, Inc. (Name of Issuer ? as specified in its charter) Common Stock, $0.0001 par value (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to desi

February 14, 2022 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the ?Exchange Act?), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the ?Schedule 13G?) relating to the Common Stock, $0.0001 par value per share, of Pliant Therapeutics,

February 14, 2022 SC 13G/A

PLRX / Pliant Therapeutics Inc / Redmile Group, LLC - SCHEDULE 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2) Pliant therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

February 11, 2022 SC 13G/A

PLRX / Pliant Therapeutics Inc / CHI Advisors LLC - CHI ADVISORS LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

January 10, 2022 EX-99.1

Developing Novel Treatments for Fibrotic Diseases Corporate Presentation JANUARY 2022 Disclaimers This presentation has been prepared by Pliant Therapeutics, Inc. ("we," "us," "our," "Pliant" or the “Company”). The information set forth herein does n

Exhibit 99.1 Developing Novel Treatments for Fibrotic Diseases Corporate Presentation JANUARY 2022 Disclaimers This presentation has been prepared by Pliant Therapeutics, Inc. ("we," "us," "our," "Pliant" or the ?Company?). The information set forth herein does not purport to be complete or to contain all of the information you may desire. Statements contained herein are made as of the date of thi

January 10, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 10, 2022 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

November 9, 2021 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2021 Financial Results

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2021 Financial Results SOUTH SAN FRANCISCO, CA ? November 9, 2021 - Pliant Therapeutics, Inc. (Nasdaq: PLRX) (?the Company?), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and reported third quarter 2

November 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS

November 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2021. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commis

September 7, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 7, 2021 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commis

September 7, 2021 EX-99.1

Pliant Therapeutics Reports Positive Interim Results from Phase 2a PET Imaging Clinical Trial in Patients with Idiopathic Pulmonary Fibrosis - Single dose administration of PLN-74809 achieved αvb6 target engagement up to 98% in the lungs of IPF patie

Exhibit 99.1 Pliant Therapeutics Reports Positive Interim Results from Phase 2a PET Imaging Clinical Trial in Patients with Idiopathic Pulmonary Fibrosis - Single dose administration of PLN-74809 achieved ?vb6 target engagement up to 98% in the lungs of IPF patients - All doses achieved target engagement above the threshold for predicted anti-fibrotic activity, with an observed dose-response relat

August 9, 2021 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2021 Financial Results - SAD cohorts up to 640 mg and MAD cohorts up to 320 mg completed in extended Phase 1a trial of PLN-74809 in healthy volunteers with no safety concerns id

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2021 Financial Results - SAD cohorts up to 640 mg and MAD cohorts up to 320 mg completed in extended Phase 1a trial of PLN-74809 in healthy volunteers with no safety concerns identified - PLN-74809 Phase 2a 12-week trials in IPF and PSC currently on track to complete enrollment by the end of 2021 and first half o

August 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC

August 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2021. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissi

July 2, 2021 EX-1.2

Controlled Equity OfferingSM Sales Agreement, dated July 2, 2021, by and between Pliant Therapeutics, Inc. and Cantor Fitzgerald & Co.

Exhibit 1.2 PLIANT THERAPEUTICS, INC. Shares of Common Stock (par value $0.0001 per share) Controlled Equity OfferingSM Sales Agreement July 2, 2021 Cantor Fitzgerald & Co. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: Pliant Therapeutics, Inc., a Delaware corporation (the ?Company?), confirms its agreement (this ?Agreement?) with Cantor Fitzgerald & Co. (the ?Agent?), as follows: 1. Is

July 2, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 29, 2021. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissio

July 2, 2021 EX-4.9

Form of Senior Indenture between Pliant Therapeutics, Inc. and one or more trustees to be named

Exhibit 4.9 PLIANT THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20[?] Senior Debt Securities TABLE OF CONTENTS1 ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee?s Certifica

July 2, 2021 EX-4.10

Form of Subordinated Indenture between Pliant Therapeutics, Inc. and one or more trustees to be named

Exhibit 4.10 PLIANT THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20[?] Subordinated Debt Securities TABLE OF CONTENTS1 ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee?s Ce

July 2, 2021 S-3ASR

As filed with the Securities and Exchange Commission on July 2, 2021

Table of Contents As filed with the Securities and Exchange Commission on July 2, 2021 Registration No.

May 10, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, IN

May 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2021. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commission

May 10, 2021 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2021 Financial Results - PLN-74809 Phase 2a PET Imaging Trial Continues to Enroll with Preliminary Data Expected First Half of 2021 - PLN-74809 Phase 2a 12-week trials in IPF and

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2021 Financial Results - PLN-74809 Phase 2a PET Imaging Trial Continues to Enroll with Preliminary Data Expected First Half of 2021 - PLN-74809 Phase 2a 12-week trials in IPF and PSC Currently on Track to Complete Enrollment by the End of 2021 and First Half of 2022, Respectively SOUTH SAN FRANCISCO - May 10, 2021

April 30, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) ? INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? ? ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for

April 30, 2021 DEF 14A

Definitive Proxy Statement

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) ? INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? ? ? Filed by a Party other than the Registrant ?? Check the appropriate box: ?? Preliminary Proxy Statement

March 16, 2021 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of December 31, 2020, Pliant Therapeutics, Inc. (the ?Company,? ?we,? ?us,? and ?our?) had one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended: our Common Stock. Description of Common Stock The following description of

March 16, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 16, 2021 Registration No.

March 16, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2021. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commissi

March 16, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39303 PLIANT THERAPEU

March 16, 2021 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2020 Financial Results - PLN-74809 Phase 2a PET Imaging Trial Resumed, with Preliminary Data Expected First Half of 2021 - PLN-74809 Phase 2a 12-week trials in IPF

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2020 Financial Results - PLN-74809 Phase 2a PET Imaging Trial Resumed, with Preliminary Data Expected First Half of 2021 - PLN-74809 Phase 2a 12-week trials in IPF and PSC Gained Momentum in the Fourth Quarter, Currently on Track to Complete Enrollment by the End of 2021 and First Half of 2022, Resp

March 2, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 7291391

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant t

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Pliant therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Pliant therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

February 16, 2021 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the “Schedule 13G”) relating to the Common Stock, $0.0001 par value per share, of Pliant Therapeutics,

February 16, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Pliant Therapeutics, Inc. (Name of Issuer) COMMON STOCK, $0.0001 PAR VALUE PER SHARE (Title of Class of S

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Pliant Therapeutics, Inc. (Name of Issuer) COMMON STOCK, $0.0001 PAR VALUE PER SHARE (Title of Class of Securities) 729139 105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to des

February 12, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. _)* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 729139105 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

January 13, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 12, 2021 PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Com

December 21, 2020 EX-3.1

Amended and Restated Bylaws

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED BYLAWS OF PLIANT THERAPEUTICS, INC. (the “Corporation”) ARTICLE I Stockholders SECTION 1. Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these Bylaws as an “Annual Meeting”) shall be held at the hour, date and place within or without the United States which is fixed by the Board of Directors, which time, date and pl

December 21, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2020. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (C

November 10, 2020 EX-99.1

Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2020 Financial Results

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2020 Financial Results - Enrollment of PLN-74809 Phase 2a 12-week trials in IPF and PSC progressing - Phase 2a PET imaging trial of PLN-74809 in IPF enrolling - Completed dosing of an extended Phase 1 dose escalation trial of PLN-74809 in healthy volunteers SOUTH SAN FRANCISCO ? November 10, 2020 ? Pliant Therapeu

November 10, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2020. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commi

November 10, 2020 EX-10.1

Offer Letter, by and between the Registrant and Mike Ouimette, dated August 17, 2020.

Exhibit 10.1 August 12, 2020 Dear Mike: We are very pleased to offer you the position of General Counsel & Corporate Secretary, at Pliant Therapeutics, Inc., a Delaware corporation (the ?Company?), with an employment commencement date by October 1, 2020. This letter outlines certain terms and conditions of your employment with the Company. We would be delighted to answer any questions you may have

November 10, 2020 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC.

August 11, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2020. PLIANT THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39303 47-4272481 (State or Other Jurisdiction of Incorporation) (Commiss

August 11, 2020 EX-3.2

Amended and Restated Bylaws of the Registrant, as currently in effect.

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF PLIANT THERAPEUTICS, INC. (the “Corporation”) ARTICLE I Stockholders SECTION 1.Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these Bylaws as an “Annual Meeting”) shall be held at the hour, date and place within or without the United States which is fixed by the Board of Directors, which time, date and place may

August 11, 2020 EX-3.1

Amended and Restated Certificate of Incorporation

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PLIANT THERAPEUTICS, INC. Pliant Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), hereby certifies as follows: 1.The name of the Corporation is Pliant Therapeutics, Inc. and that this corporation was originally incorporated pursuant to the General Corporation Law on

August 11, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39303 PLIANT THERAPEUTICS, INC.

August 11, 2020 EX-99.1

Pliant Therapeutics Provides Corporate Update and Announces Second-Quarter 2020 Financial Results -Raised over $175 million in initial public offering and concurrent private placement to advance lead product candidate PLN-74809 for the treatment of i

Exhibit 99.1 Pliant Therapeutics Provides Corporate Update and Announces Second-Quarter 2020 Financial Results -Raised over $175 million in initial public offering and concurrent private placement to advance lead product candidate PLN-74809 for the treatment of idiopathic pulmonary fibrosis and primary sclerosing cholangitis -Continued progress of Phase 2a 12-week trials of IPF and PSC with sites

June 15, 2020 SC 13G

PLRX / Pliant Therapeutics, Inc. / Novartis Institutes for BioMedical Research, Inc. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Pliant Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 729139 105 (CUSIP Number) June 5, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the r

June 15, 2020 EX-99.1

Joint Filing Agreement

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, each of the persons named below agrees to the joint filing of a Statement on Schedule 13G (including amendments thereto) with respect to the shares of Common Stock of Pliant Therapeutics, Inc., a Delaware corporation, and further agree that this Joint Filing Agreement shall b

June 9, 2020 SC 13G

PLRX / Pliant Therapeutics, Inc. / Redmile Group, LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ) PLIANT THERAPEUTICS, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 729139 105 (CUSIP Number) June 5, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuan

June 9, 2020 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the “Schedule 13G”) relating to the Common Stock, $0.0001 par value per share, of Pliant Therapeutics,

June 4, 2020 S-8

- S-8

S-8 As filed with the Securities and Exchange Commission on June 3, 2020 Registration No.

June 3, 2020 424B4

9,000,000 Shares Pliant Therapeutics, Inc. Common Stock $16.00 per share

424B4 Table of Contents File pursuant to Rule 424(b)(4) Registration No. 333-238146 9,000,000 Shares Pliant Therapeutics, Inc. Common Stock $16.00 per share This is the initial public offering of our common stock. We are selling 9,000,000 shares of common stock. Prior to this offering there has been no public market for our shares. The initial public offering price is $16.00 per share of common st

June 2, 2020 S-1/A

- S-1/A

S-1/A Table of Contents As filed with the Securities and Exchange Commission on June 2, 2020 Registration No.

May 29, 2020 8-A12B

Form 8-A

8-A12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Pliant Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 47-4272481 (State of incorporation or organization) (I.R.S. Employer Identification No.) 260 Littlef

May 29, 2020 CORRESP

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CORRESP VIA EDGAR May 29, 2020 Office of Life Science Division of Corporation Finance U.

May 29, 2020 CORRESP

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CORRESP May 29, 2020 United States Securities and Exchange Commission Office of Life Sciences Division of Corporation Finance 100 F Street, N.

May 26, 2020 CORRESP

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CORRESP Goodwin Procter LLP Three Embarcadero Center, 28th Floor San Francisco, CA 94111 goodwinlaw.

May 26, 2020 EX-3.4

Form of Amended and Restated By-laws (Incorporated by reference to Exhibit 3.4 to the registrant’s Registration Statement on Form S-1, as amended (File No. 333-238146)).

EX-3.4 Exhibit 3.4 AMENDED AND RESTATED BYLAWS OF PLIANT THERAPEUTICS, INC. (the “Corporation”) ARTICLE I Stockholders SECTION 1. Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these Bylaws as an “Annual Meeting”) shall be held at the hour, date and place within or without the United States which is fixed by the Board of Directors, which time, date and pl

May 26, 2020 S-1/A

- S-1/A

S-1/A Table of Contents As filed with the Securities and Exchange Commission on May 26, 2020 Registration No.

May 26, 2020 EX-10.3

2020 Employee Stock Purchase Plan.

EX-10.3 Exhibit 10.3 PLIANT THERAPEUTICS, INC. 2020 EMPLOYEE STOCK PURCHASE PLAN The purpose of the Pliant Therapeutics, Inc. 2020 Employee Stock Purchase Plan (the “Plan”) is to provide eligible employees of Pliant Therapeutics, Inc. (the “Company”) and each Designated Company with opportunities to purchase shares of the Company’s common stock, par value $0.0001 per share (the “Common Stock”). 70

May 26, 2020 EX-3.2

Form of Amended and Restated Certificate of Incorporation (Incorporated by reference to Exhibit 3.2 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-238146)).

EX-3.2 Exhibit 3.2 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PLIANT THERAPEUTICS, INC. Pliant Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), hereby certifies as follows: 1. The name of the Corporation is Pliant Therapeutics, Inc. and that this corporation was originally incorporated pursuant to the General Corporatio

May 26, 2020 EX-10.2

Pliant Therapeutics, Inc. 2020 Stock Option and Incentive Plan and forms of award agreements thereunder (Incorporated by reference to Exhibit 10.2 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-238146)).

EX-10.2 Exhibit 10.2 PLIANT THERAPEUTICS, INC. 2020 STOCK OPTION AND INCENTIVE PLAN SECTION 1. GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the Pliant Therapeutics, Inc. 2020 Stock Option and Incentive Plan (the “Plan”). The purpose of the Plan is to encourage and enable the officers, employees, Non-Employee Directors and Consultants of Pliant Therapeutics, Inc. (the “Company”)

May 26, 2020 EX-4.1

Specimen Common Stock Certificate

EX-4.1 Exhibit 4.1 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK COMMON STOCK PAR VALUE $0.0001 Certificate Shares Number * * 000000 ****************** * * * 000000 ***************** ZQ00000000 **** 000000 **************** PLIANT THERAPEUTICS, INC. ***** 000000 *************** ****** 000000 ************** INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE ** Mr. Alexander Davi

May 26, 2020 EX-3.1.1

Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Registrant.

Exhibit 3.1.1 CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PLIANT THERAPEUTICS, INC. (Pursuant to Section 242 of the General Corporation Law of the State of Delaware) Pliant Therapeutics, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), DO

May 26, 2020 EX-10.6

Non-Employee Director Compensation Policy.

EX-10.6 Exhibit 10.6 PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or off

May 26, 2020 EX-1.1

Form of Underwriting Agreement.

EX-1.1 Exhibit 1.1 Pliant Therapeutics, Inc. [●] Shares Common Stock ($0.0001 par value) Underwriting Agreement New York, New York [●], 2020 Citigroup Global Markets Inc. Cowen and Company, LLC Piper Sandler & Co. As Representatives of the several Underwriters c/o Citigroup Global Markets Inc. 388 Greenwich Street New York, New York 10013 c/o Cowen and Company, LLC 599 Lexington Avenue New York, N

May 13, 2020 CORRESP

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CORRESP Goodwin Procter LLP 100 Northern Avenue Boston, MA 02210 goodwinlaw.com +1 617 570 1000 CONFIDENTIAL TREATMENT REQUESTED BY PLIANT THERAPEUTICS, INC. CERTAIN PORTIONS OF THIS LETTER AS FILED VIA EDGAR HAVE BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. OMITTED INFORMATION HAS BEEN REPLACED IN THIS LETTE

May 11, 2020 EX-10.5

Prior Non-Employee Director Compensation Policy.

EX-10.5 Exhibit 10.5 Amended and Restated Non-Employee Director Compensation Policy This Amended and Restated Non-Employee Director Compensation Policy applies to non-employee directors, other than the chairperson or lead director, who are not affiliated with major investors. Subject to Board approval, the Company shall grant you, as a non-employee director of the Company, an option to purchase 18

May 11, 2020 EX-10.4

Senior Executive Cash Incentive Bonus Plan.

EX-10.4 Exhibit 10.4 PLIANT THERAPEUTICS, INC. SENIOR EXECUTIVE CASH INCENTIVE BONUS PLAN 1. Purpose This Senior Executive Cash Incentive Bonus Plan (the “Incentive Plan”) is intended to provide an incentive for superior work and to motivate eligible executives of Pliant Therapeutics, Inc. (the “Company”) and its subsidiaries toward even higher achievement and business results, to tie their goals

May 11, 2020 S-1

Registration Statement - S-1

S-1 Table of Contents As filed with the Securities and Exchange Commission on May 8, 2020 Registration No.

May 11, 2020 EX-4.2

Amended and Restated Investors’ Right Agreement by and among Pliant Therapeutics, Inc. and certain of its stockholders, dated December 19, 2019

EX-4.2 Exhibit 4.2 Execution Version PLIANT THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT December 19, 2019 AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (this “Agreement”), is made as of the 19th day of December, 2019, by and among PLIANT THERAPEUTICS, INC., a Delaware corporation (the “Company”), and each of the inves

May 11, 2020 EX-10.12

Offer Letter, by and between the Registrant and Barbara Howes, dated May 1, 2019.

EX-10.12 Exhibit 10.12 April 26, 2019 Dear Barbara Howes: We are very pleased to offer you the position of Chief Human Resources Officer, at Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), with an employment commencement date by May 1, 2019. This letter outlines certain terms and conditions of your employment with the Company. We would be delighted to answer any questions you ma

May 11, 2020 EX-10.11

Offer Letter, by and between the Registrant and Éric Lefebvre, M.D., dated February 28, 2018.

EX-10.11 Exhibit 10.11 700 Saginaw Drive, Suite 150 Redwood City, CA 94063 February 27, 2018 Eric A. Lefebvre, M.D. Re: Employment Offer Dear Eric: Pliant Therapeutics, Inc. (“Pliant” or the “Company”) is pleased to confirm its offer to employ you as Chief Medical Officer. You will report to the Company’s Chief Executive Officer, Bernard Coulie. Your effective date of hire as a regular, full time

May 11, 2020 EX-10.13

Form of Indemnification Agreement, by and between the Registrant and each of its directors and certain officers.

EX-10.13 Exhibit 10.13 PLIANT THERAPEUTICS, INC. [FORM OF] DIRECTOR AND OFFICER INDEMNIFICATION AGREEMENT This Indemnification Agreement (“Agreement”) is made as of [] by and between Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), and [] (“Indemnitee”). RECITALS WHEREAS, the Company desires to attract and retain the services of highly qualified individuals, such as Indemnitee, t

May 11, 2020 EX-10.9

Offer Letter, by and between the Registrant and Hans Hull, J.D., dated February 10, 2016.

EX-10.9 Exhibit 10.9 700 Saginaw Drive, Suite 150 Redwood City, CA 94063 February 9, 2016 Hans Hull San Francisco, CA 94110 EMAIL: Re: Employment Offer Dear Hans, Pliant Therapeutics, Inc. (“Pliant” or the “Company”) is pleased to confirm its offer to employ you as Chief Business Officer. As Chief Business Officer, you will report to the Company’s Chief Executive Officer, Bernard Coulie. Your effe

May 11, 2020 EX-10.15

Collaboration and License Agreement, by and between the Registrant and Novartis Institutes For Biomedical Research, Inc., dated October 17, 2019.

EX-10.15 Exhibit 10.15 EXECUTION COPY CONFIDENTIAL COLLABORATION AND LICENSE AGREEMENT BY AND BETWEEN NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. AND PLIANT THERAPEUTICS, INC. COLLABORATION AND LICENSE AGREEMENT This COLLABORATION AND LICENSE AGREEMENT (this "Agreement") is made as of October 17, 2019 (the "Execution Date"), by and between Novartis Institutes for Biomedical Research, Inc., a

May 11, 2020 EX-10.1

2015 Equity Incentive Plan and forms of award agreements thereunder.

EX-10.1 Exhibit 10.1 PLIANT THERAPEUTICS, INC. 2015 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: August 19, 2015 APPROVED BY THE STOCKHOLDERS: August 19, 2015 TERMINATION DATE: August 18, 2025 1. GENERAL. (a) Eligible Stock Award Recipients. Employees, Directors and Consultants are eligible to receive Stock Awards. (b) Available Stock Awards. The Plan provides for the grant of the foll

May 11, 2020 EX-10.6

Non-Employee Director Compensation Policy.

EX-10.6 Exhibit 10.6 PLIANT THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or off

May 11, 2020 EX-10.14

Office Lease, by and between the Registrant and 260 Littlefield Avenue South San Francisco, California 94080, dated February 6, 2018.

EX-10.14 Exhibit 10.14 EDGEWATER BUSINESS PARK LEASE This Lease (the “Lease”), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the “Summary”), below, is made by and between HCP, INC., a Maryland corporation (“Landlord”), and PLIANT THERAPEUTICS, INC., a Delaware corporation (“Tenant”). SUMMARY OF BASIC LEASE INFORMATION TERMS OF LEASE DESCRIPTION 1. Date: Feb

May 11, 2020 EX-10.10

Offer Letter, by and between the Registrant and Keith Cummings, M.D., MBA, dated November 29, 2018.

EX-10.10 Exhibit 10.10 November 21, 2018 Dear Keith: Position. We are very pleased to offer you the position of Chief Financial Officer of Pliant Therapeutics, Inc., a Delaware corporation (the “Company”), with an employment commencement date of not later than December 31, 2018. You will have the normal duties, responsibilities and authority of an executive serving in the position of Chief Financi

May 11, 2020 EX-10.7

Executive Severance Plan.

EX-10.7 Exhibit 10.7 PLIANT THERAPEUTICS, INC. EXECUTIVE SEVERANCE PLAN 1. Purpose. Pliant Therapeutics, Inc., a Delaware corporation (the “Company”) considers it essential to the best interests of its stockholders to foster the continuous employment of key management personnel. The Board of Directors of the Company (the “Board”) recognizes, however, that, as is the case with many publicly-held co

May 11, 2020 EX-10.8

Offer Letter, by and between the Registrant and Bernard Coulie, M.D., Ph.D., dated October 12, 2015.

EX-10.8 Exhibit 10.8 Pliant Therapeutics 700 Saginaw Drive Suite 150 Redwood City, CA 94063 Oct 7th, 2015 Bernard Coulie, MD, Ph.D. BY EMAIL: Grimdestraat 23 B-3000 Leuven BELGIUM Re: Employment Offer Pliant Therapeutics Dear Bernard: Pliant Therapeutics, Inc. (“Pliant” or the “Company”) is pleased to confirm its offer to employ you. Your effective date of hire as a regular, full time employee (th

May 11, 2020 EX-3.1

Amended and Restated Certificate of Incorporation, as amended, of the Registrant, as currently in effect.

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PLIANT THERAPEUTICS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) PLIANT THERAPEUTICS, INC., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), DOES HEREBY CERTIFY:

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