QNCX / Quince Therapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Quince Therapeutics, Inc.
US ˙ NasdaqGS ˙ US22053A1079

Mga Batayang Estadistika
CIK 1662774
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Quince Therapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 11, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits. (d) Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2025 Quince Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-38890 90-1024039 (State or Other Jurisdiction of Incorporation) (Commissi

August 11, 2025 EX-99.1

Quince Therapeutics Provides Business Update and Reports Second Quarter 2025 Financial Results Marks major milestone with completion of enrollment in pivotal Phase 3 NEAT clinical trial evaluating lead asset, eDSP, for the treatment of A-T; topline r

Exhibit 99.1 Quince Therapeutics Provides Business Update and Reports Second Quarter 2025 Financial Results Marks major milestone with completion of enrollment in pivotal Phase 3 NEAT clinical trial evaluating lead asset, eDSP, for the treatment of A-T; topline results expected in first quarter of 2026 Closed financing priced at a premium bringing existing cash position to approximately $35 millio

August 11, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 00

August 5, 2025 424B5

Up to 6,671,928 Shares of Common Stock Up to 2,000,000 Shares of Common Stock Issuable Upon Exercise of Pre-Funded Warrants Up to 8,671,928 Shares of Common Stock Issuable Upon Exercise of Warrants

424B5 Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-288971 PROSPECTUS Up to 6,671,928 Shares of Common Stock Up to 2,000,000 Shares of Common Stock Issuable Upon Exercise of Pre-Funded Warrants Up to 8,671,928 Shares of Common Stock Issuable Upon Exercise of Warrants This prospectus relates to the proposed resale from time to time by the selling stockholders of: • Up t

July 25, 2025 S-3

As filed with the Securities and Exchange Commission on July 25, 2025

Table of Contents As filed with the Securities and Exchange Commission on July 25, 2025 Registration No.

July 25, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Quince Therapeutics, Inc.

July 16, 2025 EX-99.1

Quince Therapeutics Completes Enrollment in Pivotal Phase 3 NEAT Clinical Trial in Ataxia-Telangiectasia

Exhibit 99.1 Quince Therapeutics Completes Enrollment in Pivotal Phase 3 NEAT Clinical Trial in Ataxia-Telangiectasia SOUTH SAN FRANCISCO, Calif. – July 16, 2025 – Quince Therapeutics, Inc. (Nasdaq: QNCX), a late-stage biotechnology company dedicated to unlocking the power of a patient’s own biology for the treatment of rare diseases, today announced that the company has completed enrollment in it

July 16, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2025 QUINCE THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2025 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commission

June 13, 2025 EX-4.2

Form of Common Warrant

Exhibit 4.2 THIS WARRANT AND THE SHARES OF COMMON STOCK (OR IN LIEU THEREOF, PRE-FUNDED WARRANTS (AS DEFINED BELOW)) ISSUABLE UPON THE EXERCISE OF THIS WARRANT (THE “SECURITIES”) HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES. THE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE SOLD,

June 13, 2025 EX-10.1

Form of Securities Purchase Agreement, dated June 12, 2025, by and among Quince Therapeutics, Inc. and each of the several purchasers signatory thereto.

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of June 12, 2025, by and among Quince Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the entities listed on Exhibit A attached to this Agreement (each, an “Investor” and together, the “Investors”). WHEREAS, the Company and the Investors are executing and delivering

June 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2025 Quince Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2025 Quince Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-38890 90-1024039 (State or Other Jurisdiction of Incorporation) (Commission

June 13, 2025 EX-4.1

Form of Pre-Funded Warrant

EX-4.1 Exhibit 4.1 THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THIS WARRANT (THE “SECURITIES”) HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES. THE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED UNLESS (I) SUCH SECURITIES HA

June 13, 2025 EX-10.2

Form of Registration Rights Agreement, dated June 12, 2025, by and among Quince Therapeutics, Inc. and each of the several purchasers signatory thereto.

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of June 12, 2025, is entered into by and among Quince Therapeutics, Inc., a Delaware corporation (the “Company”), and the several investors signatory hereto (individually as an “Investor” and collectively together with their respective permitted assigns, the “Investors”). Capitalized terms us

June 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2025 QUINCE THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2025 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commission

May 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Content UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 00

May 13, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2025 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organizati

May 13, 2025 EX-99.1

Quince Therapeutics Provides Business Update and Reports First Quarter 2025 Financial Results Plan to potentially conclude enrollment early for Phase 3 NEAT clinical trial in Ataxia-Telangiectasia (A-T) to align topline results with existing cash run

Exhibit 99.1 Quince Therapeutics Provides Business Update and Reports First Quarter 2025 Financial Results Plan to potentially conclude enrollment early for Phase 3 NEAT clinical trial in Ataxia-Telangiectasia (A-T) to align topline results with existing cash runway SOUTH SAN FRANCISCO, Calif. – May 13, 2025 – Quince Therapeutics, Inc. (Nasdaq: QNCX), a late-stage biotechnology company dedicated t

April 23, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 1

April 23, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Defi

April 9, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: x Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 1

March 24, 2025 EX-21.1

List of subsidiaries

Exhibit 21.1 List of Subsidiaries of Quince Therapeutics, Inc. Quince Therapeutics, Inc. subsidiaries as of December 31, 2024, are listed below. Subsidiary Jurisdiction of Incorporation Cortexyme Australia Pty Ltd Australia Novosteo, LLC Delaware Novosteo Pty Ltd Australia EryDel US, Inc. Delaware EryDel USA, Inc. New Jersey EryDel Italy, Inc. Delaware Quince Therapeutics, S.p.A Italy

March 24, 2025 EX-19.1

Insider Trading Policy

Exhibit 19.1 Quince Therapeutics, Inc. Insider Trading Policy (adopted July 25, 2023) Introduction During the course of your relationship with Quince Therapeutics, Inc. (“Quince”), you may receive material information that is not yet publicly available (“material nonpublic information”) about Quince or other publicly traded companies that Quince has business relationships with. Material nonpublic

March 24, 2025 EX-99.1

Quince Therapeutics Provides Business Update and Reports Fiscal Year 2024 Financial Results Phase 3 NEAT clinical trial exceeds 50% enrollment with new study site activations expected to accelerate screenings and randomization Existing cash position

Exhibit 99.1 Quince Therapeutics Provides Business Update and Reports Fiscal Year 2024 Financial Results Phase 3 NEAT clinical trial exceeds 50% enrollment with new study site activations expected to accelerate screenings and randomization Existing cash position of $40.8 million expected to provide operating runway through Phase 3 topline results into 2026 SOUTH SAN FRANCISCO, Calif. – March 24, 2

March 24, 2025 424B5

$21,937,722 Common Stock

424B5 Filed Pursuant to Rule 424(b)(5) Registration No. 333-283897 PROSPECTUS SUPPLEMENT (To Prospectus Dated December 26, 2024) $21,937,722 Common Stock This prospectus supplement amends and supplements the information in the prospectus, dated December 26, 2024, filed with the Securities and Exchange Commission as a part of our registration statement on Form S-3 (File No. 333-283897), or the Prio

March 24, 2025 S-8

As filed with the Securities and Exchange Commission on March 24, 2025

S-8 As filed with the Securities and Exchange Commission on March 24, 2025 Registration No.

March 24, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2025 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organiza

March 24, 2025 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 Quince Therapeutics, Inc. (“we,” “our,” “us,” or the “Company”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (“1934 Act”): our common stock. The following summary description of our capital stock is based upon our

March 24, 2025 EX-10.15

Outside Director Compensation Policy adopted April 9,2019; Amended and Restated:

Exhibit 10.15 QUINCE THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY ADOPTED: APRIL 9, 2019; ORIGINALLY EFFECTIVE: MAY 8, 2019 (the “Effective Date”) AMENDED AND RESTATED: DECEMBER 2, 2024 Each member of the Board of Directors (the “Board”) of Quince Therapeutics, Inc. (the “Company”) who is not an employee of the Company (each such member, an “Outside Director”) will receive the compensat

March 24, 2025 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Quince Therapeutics, Inc.

March 24, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Content UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-388

February 14, 2025 EX-99.1

Joint Filing Agreement

Exhibit 1 Joint Filing Agreement In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the common shares of Quince Therapeutics, Inc.

December 27, 2024 424B5

Up to $75,000,000 Common Stock

Filed Pursuant to Rule 424(b)(5) Registration No. 333-283897 PROSPECTUS Up to $75,000,000 Common Stock We have entered into a Controlled Equity OfferingSM Sales Agreement, dated December 18, 2024, or the Sales Agreement, with Cantor Fitzgerald & Co. and H.C. Wainwright & Co., LLC, or the Agents, relating to the sale of shares of our common stock, par value $0.001 per share, offered by this prospec

December 23, 2024 CORRESP

Quince Therapeutics, Inc. 611 Gateway Boulevard, Suite 273 South San Francisco, CA 94080

Quince Therapeutics, Inc. 611 Gateway Boulevard, Suite 273 South San Francisco, CA 94080 December 23, 2024 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F. Street N.E. Washington, D.C. 20549-3010 Attention: Daniel Crawford RE: Quince Therapeutics, Inc. Registration Statement on Form S-3 Filed December 18, 2024 File No. 333-283897 Ladies and Gentlemen: Quince

December 18, 2024 EX-1.2

Controlled Equity OfferingSM Sales Agreement, by and among the Company, Cantor Fitzgerald & Co. and H.C. Wainwright & Co., LLC, dated as of December 18, 2024

Exhibit 1.2 QUINCE THERAPEUTICS, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement December 18, 2024 Cantor Fitzgerald & Co. 110 East 59th Street New York, NY 10022 H.C. Wainwright & Co., LLC 430 Park Avenue New York, NY 10022 Ladies and Gentlemen: Quince Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Ag

December 18, 2024 S-3

As filed with the U.S. Securities and Exchange Commission on December 18, 2024

As filed with the U.S. Securities and Exchange Commission on December 18, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 90-1024039 (State or other jurisdiction of incorporation or organization

December 18, 2024 EX-4.4

Form of Indenture

Exhibit 4.4 QUINCE THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [], 20 Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms. 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities. 5 Section 2.02 Form of Securities and Trustee’s Certificate. 8

December 18, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Quince Therapeutics, Inc.

November 14, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organ

November 14, 2024 SC 13G/A

QNCX / Quince Therapeutics, Inc. / TANG CAPITAL MANAGEMENT LLC - AMENDMENT NO. 2 Passive Investment

Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

November 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Content UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number

November 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organ

November 13, 2024 SC 13D

QNCX / Quince Therapeutics, Inc. / Lamond David - SC 13D Activist Investment

SC 13D 1 d842349dsc13d.htm SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Quince Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 22053A107 (CUSIP Number) David A. Lamond c/o Quince Therapeutics, Inc. 611 Gateway Boulevard, Suite 273 So

November 13, 2024 EX-99.1

Quince Therapeutics Provides Business Update and Reports Third Quarter 2024 Financial Results Phase 3 NEAT clinical trial on track with 32 patients enrolled to date with majority of U.S. and European study sites now enrolling patients

Exhibit 99.1 Quince Therapeutics Provides Business Update and Reports Third Quarter 2024 Financial Results Phase 3 NEAT clinical trial on track with 32 patients enrolled to date with majority of U.S. and European study sites now enrolling patients SOUTH SAN FRANCISCO, Calif. – November 13, 2024 – Quince Therapeutics, Inc. (Nasdaq: QNCX), a late-stage biotechnology company dedicated to unlocking th

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Content UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001

August 13, 2024 EX-99.1

Quince Therapeutics Provides Business Update and Reports Second Quarter 2024 Financial Results Strong cash position expected to provide sufficient operating runway into 2026; Phase 3 topline results expected in the fourth quarter of 2025

Exhibit 99.1 Quince Therapeutics Provides Business Update and Reports Second Quarter 2024 Financial Results Strong cash position expected to provide sufficient operating runway into 2026; Phase 3 topline results expected in the fourth quarter of 2025 SOUTH SAN FRANCISCO, Calif. – August 13, 2024 – Quince Therapeutics, Inc. (Nasdaq: QNCX), a late-stage biotechnology company dedicated to unlocking t

August 13, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2024 QUINCE THERAPEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organiz

August 6, 2024 SC 13G/A

QNCX / Quince Therapeutics, Inc. / Sofinnova Partners SAS - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (Amendment No. 1) * Quince Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 22053A107 (CUSIP Number)

June 21, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organizat

June 6, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organizati

May 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Quince Th

April 24, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

April 24, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

April 11, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

April 1, 2024 EX-10.26

Accession, Amendment and Restatement Agreement to the Finance Contract relating to the Finance Contract dated 24 July 2020, as amended from time to time, by and between the Company, EryDel Italy, Inc., EryDel US, Inc., EryDel USA, Inc. EryDel S.p.A, and the European Investment Bank, dated as of October 20, 2023

Exhibit 10.26 Certain information contained in this exhibit, marked by [***], has been excluded from this exhibit in accordance with Item 601(b)(10) of Regulation S-K because the registrant has determined that it is both not material and is the type that the registrant treats as private or confidential. To: European Investment Bank 100, boulevard Konrad Adenauer L-2950 Luxembourg Luxembourg Email

April 1, 2024 EX-97.1

Incentive Compensation Recoupment Policy

Exhibit 97.1 Quince Therapeutics, Inc. Incentive Compensation Recoupment Policy 1. Introduction The Compensation Committee (the “Compensation Committee”) of the Board of Directors (the “Board”) of Quince Therapeutics, Inc., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment Poli

April 1, 2024 EX-10.27

Accession, Amendment and Restatement Agreement to the Finance Contract relating to the Finance Contract dated 24 July 2020, as amended from time to time, by and between the Company, EryDel Italy, Inc., EryDel US, Inc., EryDel USA, Inc. EryDel S.p.A, and the European Investment Bank, dated as of October 20, 2023

Exhibit 10.27 Certain information contained in this exhibit, marked by [***], has been excluded from this exhibit in accordance with Item 601(b)(10) of Regulation S-K because the registrant has determined that it is both not material and is the type that the registrant treats as private or confidential. To: Quince Therapeutics, Inc. 601 Gateway Blvd. Suite 1250 South San Francisco, CA 94080 USA Em

April 1, 2024 S-8

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-38890 Quince Therapeu

April 1, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Quince Therapeutics, Inc.

April 1, 2024 EX-10.6

2019 Equity Incentive Plan and forms of stock award agreements thereunder

Exhibit 10.6 QUINCE THERAPEUTICS, INC. 2019 EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are (a) to attract and retain the best available personnel to ensure the Company’s success and accomplish the Company’s goals; (b) to incentivize Employees, Directors and Independent Contractors with long-term equity-based compensation to align their interests with the Company’s sto

April 1, 2024 EX-21.1

List of subsidiaries

Exhibit 21.1 List of Subsidiaries of Quince Therapeutics, Inc. Entity Name Jurisdiction of Incorporation Cortexyme Australia Pty Ltd Australia Novosteo, LLC Delaware Novosteo Pty Ltd Australia EryDel US, Inc. Delaware EryDel USA, Inc. New Jersey EryDel S.p.A Italy EryDel Italy, Inc. Delaware

February 15, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation organiza

February 14, 2024 SC 13G/A

CRTX / Cortexyme Inc / TANG CAPITAL PARTNERS LP - AMENDMENT NO. 1 Passive Investment

SC 13G/A 1 o1172410sc13ga1.htm AMENDMENT NO. 1 Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Quince Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of This Statement) Check t

February 12, 2024 SC 13G

CRTX / Cortexyme Inc / Sofinnova Partners SAS - SC 13G Passive Investment

SC 13G 1 tm245842d1sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (Amendment No.) * Quince Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Sec

February 7, 2024 SC 13G/A

CRTX / Cortexyme Inc / BML Investment Partners, L.P. Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (AMENDMENT NO. 1 )* Quince Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 22053A107 (CUSIP Number) December 31

January 29, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2024 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation organizat

January 5, 2024 EX-99.2

EryDel S.p.A. Condensed Consolidated Financial Statements As of September 30, 2023 and for the three- and nine-months periods ended September 30, 2023 and 2022 Condensed Consolidated Balance Sheets 1 Condensed Consolidated Income Statements 2 Condens

EX-99.2 Exhibit 99.2 CONDENSED CONSOLIDATED FINANCIAL STATEMENTS EryDel S.p.A. As of September 30, 2023 and for the three- and nine-months periods ended September 30, 2023 and 2022 EryDel S.p.A. Condensed Consolidated Financial Statements As of September 30, 2023 and for the three- and nine-months periods ended September 30, 2023 and 2022 Contents Condensed Consolidated Balance Sheets 1 Condensed

January 5, 2024 EX-99.1

Report on the Audit of the Consolidated Financial Statements

EX-99.1 Exhibit 99.1 Independent Auditors’ Report To the Board of Directors and Shareholders Erydel S.p.A. Report on the Audit of the Consolidated Financial Statements Opinion We have audited the consolidated financial statements of Erydel S.p.A. (the Company), which comprise the consolidated balance sheet as of December 31, 2022 and 2021, and the related consolidated statements of income, compreh

January 5, 2024 EX-99.3

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

EX-99.3 Exhibit 99.3 UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION On October 20, 2023, Quince Therapeutics, Inc. (“Quince” or the “Company”) completed its previously announced acquisition (the “EryDel Acquisition”) of EryDel S.p.A. (“EryDel”), pursuant to that certain Stock Purchase Agreement, dated as of July 21, 2023, (the “Purchase Agreement”), by and among the Company, EryDel,

January 5, 2024 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 20, 2

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 20, 2023 Quince Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of inc

January 3, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 29, 2023 QUINCE THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 29, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organ

December 22, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organ

December 15, 2023 SC 13G

CRTX / Cortexyme Inc / Genextra S.p.A. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Quince Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 22053A107 (CUSIP Number) October 20, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

December 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 4, 2023 QUINCE THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 4, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organi

November 14, 2023 EX-10.4

Executive Change in Control and Severance Agreement between Quince Therapeutics, Inc. and Charles Ryan, dated as of September 1, 2023

DocuSign Envelope ID: AE44FA8A-DECF-41DD-ACE9-CDOSA9F3B77C Exhibit 10.4 QUINCE THERAPEUTICS, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the "Agreement') is made and entered into by and between Charles Ryan ("Executive") and Quince Therapeutics, Inc. (the"Company"), effective as of September 1, 2023 (the"Effective Date"). RECIT

November 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Quinc

November 14, 2023 EX-10.3

Offer Letter between Quince Therapeutics, Inc. and Charles Ryan, dated as of August 1, 2023

Exhibit 10.3 DocuSlgn Envelope ID: F7C9E685-A526-42DF•A1CB-6FBDC9B4648B August 1, 2023 Charles Ryan Via Electronic Delivery Re: Offer of Employment with Quince Therapeutics, Inc. Dear Charles: Quince Therapeutics, Inc. (the "Company") is pleased to offer you employment with the Company on the terms described below (the"Agreement''), beginning on September 1, 2023 or such date as otherwise agreed t

November 14, 2023 EX-10.2

Transition and Separation Agreement between Quince Therapeutics, Inc. and Karen Smith, dated as of August 4, 2023

DocuSign Envelope ID: D1A67A37-8755-4955-A095-4EEA855FA3B5 DocuSign Envelope ID: D11F53CA-00F3-4803-8535-AAE38A5D89AB DocuSign Envelope ID: 1088B284-F298-437C-88A2-FC7F739B18B1 Exhibit 10.

October 26, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 24, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organi

October 23, 2023 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 20, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organi

September 6, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 30, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organiz

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 4, 2023 QUINCE THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 4, 2023 QUINCE THERAPEUTICS INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commission

August 3, 2023 EX-10.1

Amendment No. 3 to License Agreement dated June 22, 2023 by and between Purdue Research Foundation and Novosteo Inc.

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) the type that the registrant treats as private or confidential.

August 3, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Quince The

July 24, 2023 EX-99.1

Transformative acquisition with value-creating clinical milestones Phase 3 lead asset EryDex targets Ataxia-Telangiectasia (A-T) with no currently approved treatments and estimated $1+ billion peak sales opportunity EryDex designed for controlled, sl

EX-99.1 Exhibit 99.1 Quince Therapeutics to Acquire EryDel July 24, 2023 Forward-looking statements Statements in this presentation contain “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject

July 24, 2023 EX-2.1

Stock Purchase Agreement, dated as of July 21, 2023 by and among Quince Therapeutics, Inc., EryDel Italy, Inc., EryDel S.p.A., certain holders and managers set forth on Schedule II thereto, and Shareholder Representative Services LLC, as the stockholder representative

EX-2.1 Exhibit 2.1 STOCK PURCHASE AGREEMENT AMONG QUINCE THERAPEUTICS, INC., ERYDEL ITALY, INC., ERYDEL S.P.A., THE SHAREHOLDERS AND THE MANAGERS SET FORTH ON SCHEDULE II HERETO AND SHAREHOLDER REPRESENTATIVE SERVICES LLC, AS HOLDER REPRESENTATIVE FOR THE SHAREHOLDERS TABLE OF CONTENTS Page ARTICLE I CERTAIN DEFINITIONS 2 ARTICLE II THE TRANSACTIONS 17 2.1 Sale and Purchase of Company Stock 17 2.2

July 24, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2023 QUINCE THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organizat

July 24, 2023 EX-99.2

Quince Therapeutics to Acquire EryDel SpA and its Phase 3 Asset Targeting Ataxia-Telangiectasia with No Currently Approved Treatments and Estimated $1+ Billion Peak Sales Opportunity Well-capitalized into 2026 with ability to fully fund lead asset Er

EX-99.2 Exhibit 99.2 NEWS RELEASE Quince Therapeutics to Acquire EryDel SpA and its Phase 3 Asset Targeting Ataxia-Telangiectasia with No Currently Approved Treatments and Estimated $1+ Billion Peak Sales Opportunity Well-capitalized into 2026 with ability to fully fund lead asset EryDex expected through Phase 3 trial under special protocol assessment (SPA) and to NDA submission EryDex utilizes au

July 17, 2023 SC 13G

CRTX / Cortexyme Inc / BML Investment Partners, L.P. - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* Quince Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 22053A107 (CUSIP Number) July 06, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to

May 25, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2023 QUINCE THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organizati

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Quince Th

May 15, 2023 EX-10.1

Lighthouse Purchase Agreement

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) the type that the registrant treats as private or confidential.

April 14, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

April 14, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) o f the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) o f the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

April 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2023 QUINCE THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) DELAWARE 001-38890 90-1024039 (State of incorporation) (Commission File No.) (IRS Employ

April 5, 2023 EX-3.1

Certificate of Designation of Series A Junior Participating Preferred Stock

EX-3.1 Exhibit 3.1 CERTIFICATE OF DESIGNATION OF RIGHTS, PREFERENCES AND PRIVILEGES OF SERIES A JUNIOR PARTICIPATING PREFERRED STOCK OF QUINCE THERAPEUTICS, INC. The undersigned, Dirk Thye, does hereby certify: 1. That he is duly elected and acting Chief Executive Officer of Quince Therapeutics, Inc., a Delaware corporation (the “Corporation”). 2. That pursuant to the authority conferred upon the

April 5, 2023 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Quince Therapeutics, Inc. (Exact name of Registrant as specified in its charter) Delaware 90-1024039 (State of other incorporation or organization) (I.R.S. Employer I.D. No.) Delaware 601 Gateway B

April 5, 2023 EX-99.1

Quince Therapeutics Adopts Limited Duration Stockholders Rights Plan

EX-99.1 Exhibit 99.1 Quince Therapeutics Adopts Limited Duration Stockholders Rights Plan SOUTH SAN FRANCISCO, Calif. – April 5, 2023 – Quince Therapeutics, Inc. (Nasdaq: QNCX), a biotechnology company focused on acquiring, developing, and commercializing innovative therapeutics that transform patients’ lives, today announced that its Board of Directors (the “Board”) unanimously approved the adopt

April 5, 2023 EX-4.1

Rights Agreement dated as of April 5, 2023, between Quince Therapeutics, Inc. and American Stock Transfer & Trust Company, LLC

EX-4.1 Exhibit 4.1 STRICTLY CONFIDENTIAL RIGHTS AGREEMENT April 5, 2023 TABLE OF CONTENTS Page SECTION 1. CERTAIN DEFINITIONS 1 SECTION 2. APPOINTMENT OF RIGHTS AGENT 7 SECTION 3. ISSUANCE OF RIGHTS. 8 SECTION 4. FORM OF RIGHT CERTIFICATES. 10 SECTION 5. COUNTERSIGNATURE AND REGISTRATION 11 SECTION 6. TRANSFER, SPLIT UP, COMBINATION AND EXCHANGE OF RIGHT CERTIFICATES; MUTILATED, DESTROYED, LOST OR

April 4, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14

March 31, 2023 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned agree to the joint filing of a Statement on Schedule 13G (including any and all amendments thereto) with respect to the Common Stock, $0.001 par value per share, of Quince Therapeutics, Inc. and further agree to the filing of this agreement as an exhibit th

March 31, 2023 SC 13G

CRTX / Cortexyme Inc / TANG CAPITAL PARTNERS LP Passive Investment

Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

March 28, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organiza

March 15, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Quince Therapeutics, Inc.

March 15, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-38890 Quince Therapeu

March 15, 2023 S-8

Power of Attorney (included on the signature page of this Registration Statement)

As filed with the Securities and Exchange Commission on March 15, 2023 Registration No.

March 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 1, 2023 QUINCE THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 1, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organizat

February 13, 2023 SC 13G/A

CRTX / Cortexyme Inc / EPQ LLC, CTYM PS - QNCX_13G_A4 Passive Investment

SC 13G/A 1 qncx13ga4.htm QNCX13GA4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* Quince Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) ý Rule 13d-1(b)

January 30, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 24, 2023 QUINCE THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 24, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organi

January 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 24, 2023 QUINCE THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 24, 2023 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organi

December 16, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 13, 2022 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organ

November 9, 2022 EX-10.1

Second Amendment to License Agreement, dated as of July 22, 2022, by and between Purdue Research Foundation and Novosteo, Inc

Exhibit 10.1 [Certain confidential portions of this agreement (marked with [***]) have been redacted pursuant to Item 601(b)(10)(iv) of Regulation S-K because the Company has determined that such redacted information is (i) not material, and (ii) is the type of information the company treats as private or confidential.] AMENDMENT #2 TO LICENSE AGREEMENT THIS AMENDMENT #2 TO LICENSE AGREEMENT (the

November 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Quinc

September 30, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2022 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or orga

August 9, 2022 EX-10.10

Executive Change in Control and Severance Agreement by and between Cortexyme, Inc. and Brendan Hannah, dated May 19, 2022

Exhibit 10.10 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Brendan Hannah (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May [19], 2022 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined tha

August 9, 2022 EX-10.18

License Agreement dated June 3, 2020, by and between Purdue Research Foundation and Novosteo Inc.

Exhibit 10.18 [Certain confidential portions of this agreement (marked with [***]) have been redacted pursuant to Item 601(b)(10)(iv) of Regulation S-K because the Company has determined that such redacted information is (i) not material, and (ii) is the type of information the company treats as private or confidential.] license Agreement THIS LICENSE AGREEMENT (this ?Agreement?) is made and enter

August 9, 2022 EX-10.2

Employment Offer Letter, by and between Cortexyme, Inc. and Brendan Hannah, dated May 9,2022

May 9, 2022 Exhibit 10.2 Brendan Hannah Via Electronic Delivery Re: Offer of Employment with Cortexyme Dear Brendan: As you are aware, Novosteo Inc. (the ?Company?), is pleased to offer you continued employment with the Company on the terms described below (the ?Agreement?). As you are aware, Cortexyme, Inc. (?Cortexyme?) is acquiring the Company (the ?Transaction?), pursuant to an Agreement and P

August 9, 2022 EX-10.17

Outside Director Compensation Policy adopted April 9,2019; Amended and Restated: June 7, 2022

Exhibit 10.17 CORTEXYME, INC. OUTSIDE DIRECTOR COMPENSATION POLICY ADOPTED: APRIL 9, 2019; AMENDED AND RESTATED: JUNE 7, 2022 EFFECTIVE: MAY 8, 2019 (the ?Effective Date?) Each member of the Board of Directors (the ?Board?) of Cortexyme, Inc. (the ?Company?) who is not an employee of the Company (each such member, an ?Outside Director?) will receive the compensation described in this Outside Direc

August 9, 2022 EX-10.15

Consent to Sublease, by and between Cortexyme, Inc. and ICON Clinical Research LLC, dated as of June 8, 2022

Exhibit 10.15 CONSENT TO SUBLEASE This Consent to Sublease (this ?Consent?) is made as of June 8, 2022, by 601 & 651 GATEWAY CENTER LP, a Delaware limited partnership, having an address of 26 North Euclid Avenue, Pasadena, California 91101, Attn: Corporate Secretary, Re: 601/651 Gateway (?Landlord?), ICON CLINICAL RESEARCH, LLC, a Delaware limited liability company, having an address of 601 Gatewa

August 9, 2022 EX-10.1

Separation Agreement, by and between Cortexyme, Inc. and Michael Detke, dated as of May 2, 2022

Exhibit 10.1 CORTEXYME, INC. May 2, 2022 Michael Detke VIA EMAIL ([email protected]) Dear Mike: This letter sets forth the substance of the separation agreement (the ?Agreement?) that Cortexyme, Inc. (the ?Company?) is offering to you to aid in your employment transition. 1. Separation. Your last day of work with the Company and your employment termination date will be May 2, 2022 (the ?Separat

August 9, 2022 EX-10.19

Amendment No. 1 to License Agreement dated March 21, 2022 by and between Purdue Research Foundation and Novosteo Inc.

Exhibit 10.19 AMENDMENT #1 TO LICENSE AGREEMENT THIS AMENDMENT #1 TO LICENSE AGREEMENT (the ?Amendment?), made and entered into this 21st day of March, 2022 (?Amendment Effective Date?) by and between Purdue Research Foundation, a corporation formed and existing under the Indiana Foundation or Holding Companies Act of 1921 with its main offices located at 1281 Win Hentschel Blvd, West Lafayette, I

August 9, 2022 EX-10.14

Sublease Agreement, by and between Cortexyme, Inc. and ICON Clinical Research LLC, dated as of May 5, 2022

Exhibit 10.14 SUBLEASE AGREEMENT THIS SUBLEASE AGREEMENT (this "Sublease") is made and entered into as of May 5 , 2022, by and between ICON Clinical Research, LLC, a Delaware limited liability company, as sublandlord ("Sublandlord"), and Cortexyme, Inc., a Delaware corporation, as subtenant ("Subtenant"). WHEREAS, Sublandlord, as Tenant, and 601 & 651 Gateway Center LP, a Delaware limited partners

August 9, 2022 EX-10.16

Separation Agreement, by and between Cortexyme, Inc. and Leslie Holsinger, dated as of July 31, 2022

Exhibit 10.16 CORTEXYME, INC. July 15, 2022 Leslie Holsinger VIA EMAIL ([email protected]) Dear Leslie: This letter sets forth the substance of the separation agreement (the "Agreement") that Cortexyme, Inc. (the "Company") is offering to you to aid in your employment transition. 1. Separation. Your last day of work with the Company and your employment termination date will be July 31, 2022

August 9, 2022 EX-10.12

Executive Change in Control and Severance Agreement by and between Cortexyme, Inc. and Dirk Thye, dated May 19, 2022

Exhibit 10.12 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Dirk Thye, MD (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May [19], 2022 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined that

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Quince The

August 9, 2022 EX-10.13

Separation Agreement, by and between Cortexyme, Inc. and Christopher Lowe, dated as of June 10, 2022

Exhibit 10.13 CORTEXYME, INC. June 10, 2022 Christopher Lowe VIA EMAIL ([email protected]) Dear Chris: This letter sets forth the substance of the separation agreement (the ?Agreement?) that Cortexyme, Inc. (the ?Company?) is offering to you to aid in your employment transition. 1. Separation. Your last day of work with the Company and your employment termination date will be June 10, 2022 (the

August 9, 2022 EX-10.9

Separation Agreement, by and between Cortexyme, Inc. and Caryn G. McDowell, dated as of May 19, 2022

Exhibit 10.9 CORTEXYME, INC. May 19, 2022 Caryn G. McDowell VIA EMAIL ([email protected]) Dear Caryn: This letter sets forth the substance of the transition separation agreement (the ?Agreement?) that Cortexyme, Inc. (the ?Company?) is offering to you to aid in your employment transition. 1. Separation. If you sign this Agreement and allow it to become effective, your employment will continu

August 9, 2022 EX-10.4

Employment Offer Letter, by and between Cortexyme, Inc. and Dirk Thye, dated May 9,2022

May 9, 2022 Exhibit 10.4 Dirk Thye, MD Via Electronic Delivery Re: Offer of Employment with Cortexyme Dear Dirk: As you are aware, Novosteo Inc. (the ?Company?), is pleased to offer you continued employment with the Company on the terms described below (the ?Agreement?). As you are aware, Cortexyme, Inc. (?Cortexyme?) is acquiring the Company (the ?Transaction?), pursuant to an Agreement and Plan

August 9, 2022 EX-10.3

Employment Offer Letter, by and between Cortexyme, Inc. and Karen Smith, dated May 9,2022

May 9, 2022 Exhibit 10.3 Karen Smith Via Electronic Delivery Re: Offer of Employment with Cortexyme Dear Karen: As you are aware, Novosteo Inc. (the ?Company?), is pleased to offer you continued employment with the Company on the terms described below (the ?Agreement?). As you are aware, Cortexyme, Inc. (?Cortexyme?) is acquiring the Company (the ?Transaction?), pursuant to an Agreement and Plan o

August 9, 2022 EX-10.11

Executive Change in Control and Severance Agreement, by and between Cortexyme, Inc. and Karen Smith, dated as of May 19, 2022

Exhibit 10.11 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Karen Smith (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May [19], 2022 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined that i

August 1, 2022 EX-99.1

Quince Therapeutics Details Strategic Growth Plan with Launch of New Corporate Name Strategic focus centered on advancing innovative precision therapeutics for debilitating and rare diseases Highly differentiated bone-targeting drug platform and lead

Exhibit 99.1 NEWS RELEASE Quince Therapeutics Details Strategic Growth Plan with Launch of New Corporate Name Strategic focus centered on advancing innovative precision therapeutics for debilitating and rare diseases Highly differentiated bone-targeting drug platform and lead precision bone growth molecule NOV004 to address underserved therapeutic areas with major, unmet medical needs Pursuing str

August 1, 2022 EX-3.2

Amended and Restated Bylaws

Exhibit 3.2 QUINCE THERAPEUTICS, INC. a Delaware Corporation AMENDED AND RESTATED BYLAWS QUINCE THERAPEUTICS, INC. a Delaware Corporation AMENDED AND RESTATED BYLAWS TABLE OF CONTENTS Page ARTICLE I: STOCKHOLDERS 1 Section 1.1: Annual Meetings 1 Section 1.2: Special Meetings 1 Section 1.3: Notice of Meetings 1 Section 1.4: Adjournments 1 Section 1.5: Quorum 2 Section 1.6: Organization 2 Section 1.

August 1, 2022 EX-3.1

Certificate of Amendment to the registrant’s Certificate of Incorporation, effective August 1, 2022

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF CORTEXYME, INC. Cortexyme, Inc., a corporation organized and existing under the laws of the State of Delaware (the ?Corporation?), does hereby certify as follows: A. The Corporation was originally incorporated, and the original Certificate of Incorporation was filed with the Secretary of State of the State

August 1, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2022 QUINCE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commissio

July 22, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 20, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commission File Numb

July 8, 2022 SC 13G/A

CRTX / Cortexyme Inc / Capital World Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) June 30, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule i

June 10, 2022 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (Commi

May 25, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

May 20, 2022 EX-99.4

Novosteo Inc. 2019 Equity Incentive Plan

Exhibit 99.4 NOVOSTEO INC. 2019 EQUITY INCENTIVE PLAN APPROVED BY THE BOARD OF DIRECTORS: May 20, 2019 APPROVED BY THE STOCKHOLDERS: May 20, 2019 AMENDED BY THE BOARD OF DIRECTORS: August 11, 2020 APPROVED BY THE STOCKHOLDERS: August 11, 2020 AMENDED BY THE BOARD OF DIRECTORS: December 16, 2020 APPROVED BY THE STOCKHOLDERS: December 29, 2020 1. Purposes of the Plan. The purposes of this Plan are:

May 20, 2022 EX-99.1

Cortexyme, Inc. 2022 Inducement Plan

EX-99.1 4 d265791dex991.htm EX-99.1 Exhibit 99.1 CORTEXYME, INC. 2022 INDUCEMENT PLAN 1. Purposes of the Plan; Eligible Recipients; Types of Awards. This Plan, through the granting of Awards, is intended to provide (i) an inducement material for certain individuals to enter into employment with the Company within the meaning of Rule 5635(c)(4) of the NASDAQ Marketplace Rules, (ii) incentives for s

May 20, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Cortexyme, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 pe

May 20, 2022 EX-99.3

Forms of Restricted Stock Unit Award Agreement and Notice of Restricted Stock Unit Grant Cortexyme, Inc. 2022 Inducement Plan

Exhibit 99.3 CORTEXYME, INC. 2022 INDUCEMENT PLAN RESTRICTED STOCK UNIT AWARD AGREEMENT Unless otherwise defined herein, the terms defined in the Cortexyme, Inc. 2022 Inducement Plan (the ?Plan?) will have the same defined meanings in this Restricted Stock Unit Award Agreement (the ?Award Agreement?). I. NOTICE OF RESTRICTED STOCK UNIT GRANT Participant Name: You have been granted the right to rec

May 20, 2022 S-8

As filed with the Securities and Exchange Commission on May 20, 2022

As filed with the Securities and Exchange Commission on May 20, 2022 Registration No.

May 20, 2022 EX-99.2

Forms of Stock Option Award Agreement, Notice of Stock Option Grant and Exercise Notice under Cortexyme, Inc. 2022 Inducement Plan

Exhibit 99.2 CORTEXYME, INC. 2022 INDUCEMENT PLAN STOCK OPTION AWARD AGREEMENT Unless otherwise defined herein, the terms defined in the Cortexyme, Inc. 2022 Inducement Plan (the ?Plan?) will have the same defined meanings in this Stock Option Award Agreement (the ?Award Agreement?). I. NOTICE OF STOCK OPTION GRANT Participant Name: You have been granted an Option to purchase Common Stock of Corte

May 20, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 19, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commission File Numbe

May 19, 2022 424B5

Up to $150,000,000 Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-238851 PROSPECTUS Up to $150,000,000 Common Stock We have entered into an Open Market Sale AgreementSM, or the sales agreement, with Jefferies LLC, or Jefferies, relating to the sale of shares of our common stock offered by this prospectus. In accordance with the terms of the sales agreement, we may offer and sell shares of ou

May 17, 2022 POS EX

As filed with the Securities and Exchange Commission on May 17, 2022

POS EX 1 d356169dposex.htm POS EX As filed with the Securities and Exchange Commission on May 17, 2022 Registration No. 333-238851 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 3 to FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 90-1024039 (State

May 12, 2022 EX-2.1

Agreement and Plan of Merger and Reorganization, dated as of May 9, 2022 by and among Cortexyme,Inc., Novosteo Inc., Quince Merger Sub I, Inc., Quince Merger Sub II, LLC and Fortis Advisors LLC

Exhibit 2.1 Execution Version AGREEMENT AND PLAN OF MERGER AND REORGANIZATION BY AND AMONG CORTEXYME, INC QUINCE MERGER SUB I, INC. QUINCE MERGER SUB II, LLC NOVOSTEO INC. AND FORTIS ADVISORS LLC, AS THE SECURITYHOLDERS? REPRESENTATIVE DATED AS OF MAY 9, 2022 TABLE OF CONTENTS PAGE SECTION 1. DESCRIPTION OF TRANSACTION 1 1.1 The Merger 1 1.2 Effect of the Merger 2 1.3 Closing; Effective Time 3 1.4

May 12, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation) (Commission File Number

May 10, 2022 EX-99.1

Cortexyme Announces Agreement to Acquire Novosteo Expanding pipeline with addition of targeted therapeutics to treat rare skeletal diseases, bone cancer and injury Strengthening leadership team with appointment of Novosteo executives Dr. Dirk Thye as

Exhibit 99.1 Cortexyme Announces Agreement to Acquire Novosteo Expanding pipeline with addition of targeted therapeutics to treat rare skeletal diseases, bone cancer and injury Strengthening leadership team with appointment of Novosteo executives Dr. Dirk Thye as CEO and Dr. Karen Smith as CMO of combined company Planning corporate name change to Quince Therapeutics to reflect broadening of therap

May 10, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2022 CORTEXYME, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-38890 90-1024039 (State or Other Jurisdiction of Incorporation) (Commission File Number

May 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Cortexyme

May 2, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 26, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (Com

April 27, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 d252143ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as

April 27, 2022 DEF 14A

Definitive Proxy Statement

DEF 14A 1 d337053ddef14a.htm DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Com

March 15, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (Com

March 4, 2022 POS AM

As filed with the Securities and Exchange Commission on March 4, 2022

Table of Contents As filed with the Securities and Exchange Commission on March 4, 2022 Registration No.

March 1, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-38890 Cortexyme, Inc.

March 1, 2022 EX-10.2

Severance Agreement, dated February 1, 2022, between Stephen Dominy and the Registrant

Exhibit 10.2 CORTEXYME, INC. February 1, 2022 Stephen S. Dominy, M.D. VIA EMAIL Dear Steve: This letter sets forth the substance of the separation agreement (the ?Agreement?) that Cortexyme, Inc. (the ?Company?) is offering to you to aid in your employment transition. 1. Separation. You and the Company have mutually decided to end your employment. Your last day of work with the Company and your em

March 1, 2022 S-8

As filed with the Securities and Exchange Commission on March 1, 2022

As filed with the Securities and Exchange Commission on March 1, 2022 Registration No.

March 1, 2022 EX-10.1

Severance Agreement, dated February 1, 2022, between Casey Lynch and the Registrant

EX-10.1 2 crtx-ex101.htm EX-10.1 Exhibit 10.1 CORTEXYME, INC. February 1, 2022 Casey C. Lynch VIA EMAIL Dear Casey: This letter sets forth the substance of the separation agreement (the “Agreement”) that Cortexyme, Inc. (the “Company”) is offering to you to aid in your employment transition. 1. Separation. You and the Company have mutually decided to end your employment. Your last day of work with

March 1, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Cortexyme, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 pe

February 14, 2022 SC 13G/A

CRTX / Cortexyme Inc / PFIZER INC - SC 13G/A 3 CORTEXYME Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 3) 1 Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2021

February 14, 2022 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 cortexymesc13ga1xexhx99x1.htm EX-99.1 JOINT FILING AGREEMENT CUSIP No. 22053A107 EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the statement on Schedule 13G to which this Agreement is annexed as Exhibit 99.1, and any amendments thereto, is and will be filed on behalf of each of them in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange A

February 11, 2022 SC 13G/A

CRTX / Cortexyme Inc / Capital Research Global Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedu

February 11, 2022 SC 13G/A

CRTX / Cortexyme Inc / Capital World Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedu

February 7, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Post-Effective Amendment to Form S-3 (Form Type) Cortexyme, Inc.

February 7, 2022 EX-4.8

Form of indenture

Exhibit 4.8 Cortexyme, Inc., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20 Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee?s Certificate 8 Section 2.0

February 7, 2022 POSASR

As filed with the Securities and Exchange Commission on February 7, 2022

Table of Contents As filed with the Securities and Exchange Commission on February 7, 2022 Registration No.

February 2, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 28, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

January 26, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 25, 2022 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

December 23, 2021 EX-10.1

Open Market Sales AgreementSM dated December 23, 2021, by and between Cortexyme, Inc. and Jefferies LLC

EX-10.1 3 d221389dex101.htm EX-10.1 Exhibit 10.1 OPEN MARKET SALE AGREEMENTSM December 23, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Cortexyme, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”),

December 23, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 23, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (

December 23, 2021 424B5

CALCULATION OF REGISTRATION FEE Title of Securities to be Registered Proposed Maximum Aggregate Offering Price Amount of Registration Fee(1) Common Stock, par value $0.001 per share $150,000,000 $13,905.00

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-238851 CALCULATION OF REGISTRATION FEE Title of Securities to be Registered Proposed Maximum Aggregate Offering Price Amount of Registration Fee(1) Common Stock, par value $0.001 per share $150,000,000 $13,905.00 (1) Calculated pursuant to Rule 457(o) under the Securities Act of 1933, as amended (the ?Securities Act?), based o

December 10, 2021 SC 13G/A

CRTX / Cortexyme Inc / Capital International Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) November 30, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedu

December 10, 2021 SC 13G/A

CRTX / Cortexyme Inc / Capital International Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) November 30, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedu

October 29, 2021 EX-10.1

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Ted Monohon, dated as of September 21, 2021

Exhibit 10.1 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Ted Monohon (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of September 21, 2021 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined tha

October 29, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Corte

October 26, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 26, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

October 8, 2021 SC 13G/A

CRTX / Cortexyme Inc / Capital International Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) September 30, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Sched

October 8, 2021 SC 13G/A

CRTX / Cortexyme Inc / Capital International Investors - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) September 30, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Sched

August 6, 2021 EX-10.5

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Michael Detke, Dated as of May 18, 2021

Exhibit 10.5 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Michael Detke (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May 21, 2020 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined that it

August 6, 2021 EX-10.4

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Leslie Holsinger, Dated as of May 18, 2021

Exhibit 10.4 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Leslie Holsinger, Ph.D. (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May 18, 2020 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determin

August 6, 2021 EX-10.6

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Stephen S. Dominy, M.D., dated as of May 19, 2021

Exhibit 10.6 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Stephen S. Dominy, M.D. (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May 19, 2020 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determin

August 6, 2021 EX-10.7

Third Amendment to Sub-Sublease by and between Cortexyme, Inc. and Verily Life Sciences LLC dated July 15,2021

Exhibit 10.7 THIRD AMENDMENT TO SUB-SUBLEASE THIS THIRD AMENDMENT TO SUB-SUBLEASE (this "Third Amendment ") is made and entered into effective as of July 15, 2021 (the "Effective Date"), by and between VERILY LIFE SCIENCES LLC, a Delaware limited liability company ("Sub-Sublandlord"), and CORTEXYME, INC., a Delaware corporation ("Sub-Subtenant"). R E C I T A L S: A Sub-Sublandlord and Sub-Subtenan

August 6, 2021 EX-10.1

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Casey C. Lynch, dated as of May 19, 2021

Exhibit 10.1 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Casey C. Lynch (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May 19, 2020 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined that i

August 6, 2021 EX-10.2

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Caryn McDowell, Dated as of May 18, 2021

Exhibit 10.2 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Caryn McDowell (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May 18, 2020 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined that i

August 6, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Cortexyme,

August 6, 2021 EX-10.3

Change in Control and Severance Agreement, by and between Cortexyme Inc. and Christopher Lowe, Dated as of May 18, 2021

Exhibit 10.3 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the ?Agreement?) is made and entered into by and between Christopher Lowe (?Executive?) and Cortexyme, Inc. (the ?Company?), effective as of May 18, 2020 (the ?Effective Date?). RECITALS 1. The Board of Directors of the Company (the ?Board?) has determined that

June 18, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (Comm

May 18, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (Commi

May 6, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Cortexyme

April 30, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

April 30, 2021 DEF 14A

Definitive Proxy Statement

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14

April 27, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Amendment No. 2) Under the Securities Exchange Act of 1934 CORTEXYME, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 (Title of Class of Securities) 22053A 107

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Amendment No. 2) Under the Securities Exchange Act of 1934 CORTEXYME, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 (Title of Class of Securities) 22053A 107 (CUSIP Number) DECEMBER 31, 2020 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pur

March 25, 2021 EX-99.1

JOINT FILING AGREEMENT

CUSIP No. 22053A107 EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the statement on Schedule 13G to which this Agreement is annexed as Exhibit 99.1, and any amendments thereto, is and will be filed on behalf of each of them in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended. Dated: March 25, 2021 PFIZER INC. By: /s/ Susan

March 25, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 22053A107 (CUSIP Number) March 16, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursu

March 10, 2021 SC 13G/A

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) February 26, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedu

March 1, 2021 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 Cortexyme, Inc. (?we,? ?our,? ?us,? or the ?Company?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (?1934 Act?): our common stock. The following summary of the terms of our common stock is based upon our amended an

March 1, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 1, 2021 Registration No.

March 1, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-38890 Cortexyme, Inc.

February 16, 2021 EX-99.1

JOINT FILING AGREEMENT

CUSIP No. 22053A107 EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the statement on Schedule 13G to which this Agreement is annexed as Exhibit 99.1, and any amendments thereto, is and will be filed on behalf of each of them in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended. Dated: February 12, 2021 PFIZER INC. By: /s/ Su

February 16, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 12, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

February 16, 2021 SC 13G

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 16, 2021 SC 13G

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 16, 2021 EX-99.1

Cortexyme Provides Regulatory Update on Development Program for Atuzaginstat in Alzheimer’s Disease — Double-blind phase of GAIN Trial to continue as planned, with top-line data expected Q4 2021 — Open-Label Extension of atuzaginstat to stop dosing a

EX-99.1 2 d139193dex991.htm EX-99.1 Exhibit 99.1 Cortexyme Provides Regulatory Update on Development Program for Atuzaginstat in Alzheimer’s Disease — Double-blind phase of GAIN Trial to continue as planned, with top-line data expected Q4 2021 — Open-Label Extension of atuzaginstat to stop dosing and enrollment SOUTH SAN FRANCISCO, Calif. – February 15, 2021 – Cortexyme, Inc. (NASDAQ: CRTX), a cli

February 16, 2021 SC 13G/A

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedu

February 16, 2021 SC 13G

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Cortexyme, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 10, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 9, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

February 1, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)*

crtx13ga3.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) ý Rule 13d-1(b) ¨ Rule 13d-1(c) ¨ Rule 13d-1(d

January 29, 2021 EX-99.1

Identification of the subsidiary which acquired the security being reported on by the parent holding company

Exhibit 99.1 Identification of the subsidiary which acquired the security being reported on by the parent holding company. The reported securities are beneficially owned by Takeda Ventures, Inc., a direct wholly-owned subsidiary of Takeda Pharmaceuticals U.S.A., Inc., which, in turn, is a direct subsidiary of Takeda Pharmaceuticals International AG and Takeda Pharmaceutical Company Limited. Takeda

January 29, 2021 EX-99.2

Joint Filing Agreement

EX-99.2 3 exhibit992-012821.htm EX-99.2 Exhibit 99.2 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Common Stock of Cortexyme, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(d) under the Securities Exchange Act of 1934, as ame

January 29, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* CORTEXYME, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* CORTEXYME, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

January 26, 2021 8-K

Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 26, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

January 26, 2021 EX-99.1

Cortexyme Announces Pipeline Update and Anticipated 2021 Milestones — Based upon successful completion of the GAIN Trial’s interim analysis, pipeline expansion announced for 2021 — Atuzaginstat to be studied in the PEAK trial, a new Phase 2 study for

EX-99.1 Exhibit 99.1 Investor Contact: Chris Lowe Cortexyme, Inc. Chief Financial Officer [email protected] Media Contact: Hal Mackins For Cortexyme, Inc. [email protected] (415) 994-0040 Cortexyme Announces Pipeline Update and Anticipated 2021 Milestones — Based upon successful completion of the GAIN Trial’s interim analysis, pipeline expansion announced for 2021 — Atuzaginstat to be studied

January 25, 2021 8-K

- 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 19, 2021 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization

December 4, 2020 8-K

Other Events - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 4, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization

November 12, 2020 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Corte

August 14, 2020 EX-10.3

Separation Agreement by and between Kristen Gafric and Cortexyme, Inc., dated as of April 27, 2020.

Exhibit 10.3 269 East Grand Ave. South San Francisco, CA 94080 April 27, 2020 Kristen Gafric 2845 Union Street San Diego, CA 92103 Dear Kristen: This letter (the “Agreement”) confirms the agreement between you and Cortexyme, Inc., a Delaware corporation (the “Company”), regarding the end of your employment with the Company. 1.Resignation. By signing this Agreement, you hereby confirm your prior re

August 14, 2020 EX-10.1

Second Amendment to Sub-Sublease by and between Cortexyme, Inc. and Verily Life Sciences LLC dated May 26, 2020

Exhibit 10.1 SECOND AMENDMENT TO SUB‑SUBLEASE THIS SECOND AMENDMENT TO SUB‑SUBLEASE (this “Second Amendment”) is made and entered into effective as of May 26, 2020 (the “Effective Date”), by and between VERILY LIFE SCIENCES LLC, a Delaware limited liability company (“Sub‑Sublandlord”), and CORTEXYME, INC., a Delaware corporation (“Sub‑Subtenant”). R E C I T A L S : A.Sub‑Sublandlord and Sub‑Subten

August 14, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Cortexyme,

June 10, 2020 8-K

Submission of Matters to a Vote of Security Holders

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

June 1, 2020 S-3ASR

Power of Attorney (previously filed with the SEC)

S-3ASR Table of Contents As filed with the Securities and Exchange Commission on June 1, 2020 Registration No.

June 1, 2020 EX-4.8

Form of Indenture

EX-4.8 Exhibit 4.8 CORTEXYME, INC. AND , as Trustee, INDENTURE Dated as of Debt Securities Reconciliation and tie between Trust Indenture Act of 1939, as amended, and the Indenture Trust Indenture Act Section Indenture Section (S)310(a)(1) 6.8 (a)(2) 6.8 (b) 6.9 (S)312(a) 7.1 (b) 7.2 (c) 7.2 (S)313(a) 7.3 (b)(2) 7.3 (c) 7.3 (d) 7.3 (S)314(a) 7.4 (c)(1) 1.2 (c)(2) 1.2 (e) 1.2 (f) 1.2 (S)316(a) (las

May 21, 2020 EX-10.1

Form of Executive Change in Control and Severance Agreement.

EX-10.1 Exhibit 10.1 CORTEXYME, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Executive Change in Control and Severance Agreement (the “Agreement”) is made and entered into by and between (“Executive”) and Cortexyme, Inc. (the “Company”), effective as of , (the “Effective Date”). RECITALS 1. The Board of Directors of the Company (the “Board”) has determined that it is in the best i

May 21, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 18, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

May 12, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Cortexyme

May 12, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

May 12, 2020 EX-99.1

Cortexyme Announces First Quarter 2020 Financial Results and Provides Business Update — Interim analysis for the GAIN Trial on track for Q4 2020, with top-line results from study’s final analysis expected in Q4 2021 — Cortexyme shared additional scie

EX-99.1 Exhibit 99.1 Investor Contact: Chris Lowe Cortexyme, Inc. Chief Financial Officer [email protected] Media Contact: Hal Mackins For Cortexyme, Inc. [email protected] (415) 994-0040 Cortexyme Announces First Quarter 2020 Financial Results and Provides Business Update — Interim analysis for the GAIN Trial on track for Q4 2020, with top-line results from study’s final analysis expected in

April 30, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization)

April 22, 2020 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ?Preliminary Proxy Statement ?Confidential, for Use of the Commission Only (as permitted by Rule 14a?6(e)(2)) ?Definiti

April 22, 2020 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A 1 crtx-def14a20191231.htm DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (a

April 13, 2020 424B3

2,500,000 Shares Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-237594 2,500,000 Shares Common Stock This prospectus relates to the resale, from time to time, of up to 2,500,000 shares of our common stock by the selling stockholders (which term, as used in this prospectus, includes pledgees, donees, transferees or other successors-in-interest) identified in this prospectus. The selling sto

April 9, 2020 CORRESP

-

CORRESP 269 East Grand Ave. South San Francisco, CA 94080 April 9, 2020 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Chris Edwards, Office of Life Sciences Re: Cortexyme, Inc. Registration Statement on Form S-1 Filed April 7, 2020 File No. 333-237594 REQUEST FOR ACCELERATION OF EFFECTIVENESS Acceleration Request R

April 7, 2020 S-1

As filed with the Securities and Exchange Commission on April 7, 2020

Table of Contents As filed with the Securities and Exchange Commission on April 7, 2020 Registration No.

March 17, 2020 EX-99.1

Cortexyme Announces Fourth Quarter and Full Year 2019 Financial Results and Provides Business Update — Following initial public offering and private placement, Cortexyme is well capitalized and focused on high quality execution of the Phase 2/3 GAIN

Exhibit 99.1 Investor Contact: Chris Lowe Cortexyme, Inc. Chief Financial Officer [email protected] Media Contact: Hal Mackins For Cortexyme, Inc. [email protected] (415) 994-0040 Cortexyme Announces Fourth Quarter and Full Year 2019 Financial Results and Provides Business Update ? Following initial public offering and private placement, Cortexyme is well capitalized and focused on high qualit

March 17, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 17, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (Com

March 16, 2020 S-8

As filed with the Securities and Exchange Commission on March 16, 2020

As filed with the Securities and Exchange Commission on March 16, 2020 Registration No.

March 16, 2020 EX-4.3

Description of Securities

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 Cortexyme, Inc. (?we,? ?our,? ?us,? or the ?Company?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (?1934 Act?): our common stock. The following summary of the terms of our common stock is based upon our amende

March 16, 2020 10-K

March 16, 2020

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-38890 Cortexyme, Inc.

February 11, 2020 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Cortexyme, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 22053A 10

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Cortexyme, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 22053A 107 (CUSIP Number) February 10, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

February 6, 2020 EX-99.1

Cortexyme Announces $125 Million Private Placement

Exhibit 99.1 Media Contact: Hal Mackins For Cortexyme, Inc. [email protected] (415) 994-0040 Cortexyme Announces $125 Million Private Placement SOUTH SAN FRANCISCO, Calif. ? February 5, 2020 ? Cortexyme, Inc. (Nasdaq: CRTX), a clinical stage biopharmaceutical company pioneering a novel disease-modifying therapeutic approach to treat Alzheimer?s and other degenerative diseases, today announced th

February 6, 2020 EX-4.1

Form of Stock Purchase Agreement

Exhibit 4.1 FORM OF STOCK PURCHASE AGREEMENT This Stock Purchase Agreement (this ?Agreement?) is made as of February 5, 2020 (the ?Effective Date?) by and between Cortexyme, Inc., a Delaware corporation (the ?Company?), and [] (?Purchaser?). 1. Issuance of Shares. Effective as the Effective Date, the Company agrees to issue and sell to Purchaser [] shares (the ?Shares?) of the Company?s Common Sto

February 6, 2020 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 5, 2020 CORTEXYME, INC. (Exact name of registrant as specified in its charter) Delaware 001-38890 90-1024039 (State or other jurisdiction of incorporation or organization) (C

January 7, 2020 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Cortexyme, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 22053A107 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) ? Rule 13d-1(b) ? Rule 13d-1(c) ? Rule 13d-1(d) *The remaind

November 12, 2019 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38890 Corte

September 30, 2019 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. __)* Cortexyme, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 22053A 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Cortexyme, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 22053A 107 (CUSIP Number) September 30, 2019 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

September 30, 2019 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. __)* Cortexyme, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 22053A 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Cortexyme, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 22053A 107 (CUSIP Number) September 30, 2019 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

August 9, 2019 EX-10.1

Amendment No. 1 to Sub-Sublease by and between Cortexyme, Inc. and Verily Life Sciences LLC dated April 2, 2019.

EXHIBIT 10.1 Amendment 1 to Sub-Sublease This Amendment (this ?Amendment?) is effective as of the date of last signature below (?Amendment Effective Date?) by and between Verily Life Sciences LLC (?Sub-Sublandlord?) and Cortexyme, Inc. (?Sub-Subtenant?) Reference is made to that certain Sub-Sublease by and between the Parties, dated as of June 18, 2018 (the ?Sub-Sublease?). All capitalized terms n

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