XNCR / Xencor, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Xencor, Inc.
US ˙ NasdaqGM ˙ US98401F1057

Mga Batayang Estadistika
LEI 549300V5IF65437JKG30
CIK 1326732
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Xencor, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 6, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 6, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2025 XENCOR, INC. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number

August 6, 2025 EX-99.1

Xencor Reports Second Quarter 2025 Financial Results

Exhibit 99.1 Xencor Reports Second Quarter 2025 Financial Results PASADENA, Calif.-August 6, 2025- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and autoimmune diseases, today reported financial results for the second quarter ended June 30, 2025 and provided recent business and clinical program updates. "Xencor i

August 6, 2025 EX-10.1

Xencor, Inc. Amended and Restated 2023 Equity Incentive Plan.

Exhibit 10.1 Xencor, Inc. Amended and Restated 2023 Equity Incentive Plan Adopted by the Board of Directors: April 18, 2025 Approved by the Stockholders: June 12, 2025 1.General. (a)Plan Purpose. The Company, by means of the Plan, seeks to secure and retain the services of Employees, Directors and Consultants, to provide incentives for such persons to exert maximum efforts for the success of the C

July 31, 2025 EX-99.1

Xencor Appoints Raymond Deshaies, Ph.D., to Board of Directors

Exhibit 99.1 Xencor Appoints Raymond Deshaies, Ph.D., to Board of Directors PASADENA, Calif.-July 3131, 2025- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and autoimmune diseases, today announced the appointment of Raymond J. Deshaies, Ph.D., to its board of directors. Dr. Deshaies is a pioneering biochemist and

July 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2025 XENCOR, INC. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Number)

June 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2025 XENCOR, INC. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Number)

May 7, 2025 EX-99.1

Xencor Reports First Quarter 2025 Financial Results -- Recent interim Phase 1 study results for XmAb942 (Xtend™ anti-TL1A) support a 12-week maintenance dosing interval in XENITH-UC, a Phase 2b study in participants with ulcerative colitis, to begin

Exhibit 99.1 Xencor Reports First Quarter 2025 Financial Results - Recent interim Phase 1 study results for XmAb942 (Xtend™ anti-TL1A) support a 12-week maintenance dosing interval in XENITH-UC, a Phase 2b study in participants with ulcerative colitis, to begin in the second half of 2025 - - Chief development officer and former independent director, Nancy Valente, M.D., to transition to senior adv

May 7, 2025 EX-10.1

ny and John J. Kuch

Exhibit 10.1 ***Certain identified information has been excluded from the exhibit because it both (i) is not material and (ii) is the type that the company treats as private or confidential. Such omitted information is indicated by brackets (“[...***...]”) in this exhibit.*** April 19, 2024 John Kuch [...***...] [...***...] Re: Separation Agreement Dear John, This letter sets forth the substance o

May 7, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number) (

May 7, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

April 30, 2025 EX-99.1

® Interim Results from First-in-Human Study of XmAb942 & TL1A Pipeline Update April 29, 2025 2 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward- looking sta

xncr-20250429xexx991 ® Interim Results from First-in-Human Study of XmAb942 & TL1A Pipeline Update April 29, 2025 2 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward- looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

April 30, 2025 EX-99.2

Xencor Announces Positive Interim Results From First-in-Human Healthy Volunteer Study of XmAb942, a High-Potency Extended Half-Life Anti-TL1A Antibody, in Development for Treatment of Inflammatory Bowel Disease -- XENITH-UC, a Phase 2b study of XmAb9

Exhibit 99.2 Xencor Announces Positive Interim Results From First-in-Human Healthy Volunteer Study of XmAb942, a High-Potency Extended Half-Life Anti-TL1A Antibody, in Development for Treatment of Inflammatory Bowel Disease - XENITH-UC, a Phase 2b study of XmAb942 in participants with ulcerative colitis, to begin in the second half of 2025 - - Single and multiple doses of XmAb942 are well tolerate

April 30, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Number

April 23, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy State

April 23, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy State

March 13, 2025 8-K/A

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A Amendment No. 1 CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (C

March 13, 2025 EX-16.1

Letter from RSM US LLP, dated March 12, 2025.

44 Montgomery St Suite 3900 San Francisco, CA 94104 T +1 415 848 5300 F +1 415 848 5353 www.rsmus.com March 12, 2025 Securities and Exchange Commission Washington, D.C. 20549 Commissioners: We have read Xencor, Inc.’s statements included under Item 4.01(a) of its Form 8-K filed on March 5, 2025, and we agree with such statements concerning our firm.

March 13, 2025 EX-99.1

Xencor Appoints Todd Simpson to Board of Directors

Exhibit 99.1 Xencor Appoints Todd Simpson to Board of Directors PASADENA, Calif.- Mar. 13, 2025- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and autoimmune diseases, today announced the appointment of Todd Simpson to its board of directors. Mr. Simpson has more than 40 years of experience in chief financial off

March 13, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Number

March 5, 2025 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Num

February 27, 2025 EX-10.6

Form of

Exhibit 10.6 Xencor, Inc. 2023 Equity Incentive Plan Option Agreement (Incentive Stock Option or Nonstatutory Stock Option) Pursuant to your Stock Option Grant Notice (“Grant Notice”) and this Option Agreement, Xencor, Inc. (the “Company”) has granted you an option under its 2023 Equity Incentive Plan (the “Plan”) to purchase the number of shares of the Company’s Common Stock indicated in your Gra

February 27, 2025 EX-19

Insider Trading Policy.

CORP-LEG-003 Rev. 6 Title: Insider Trading Policy POLICY: It is the policy of Xencor, Inc. (“Company”) that directors, officers and other employees and consultants (and any persons to whom they disclose such information) shall not Trade (defined below) securities of the Company or another publicly-traded company with which the Company has business dealings (a “Third Party”) when in the possession

February 27, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Num

February 27, 2025 EX-21.1

List of Subsidiaries of Xencor, Inc.

Exhibit 21.1 XENCOR, INC. The following is the subsidiary of the Company as of December 31, 2024: SUBSIDIARY (Name under which subsidiary does business) STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION Gale Therapeutics Inc. Delaware

February 27, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 o TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36182 Xencor, Inc.

February 27, 2025 EX-10.30

First Amendment to the Collaboration and License Agreement, dated March 23, 2012, by and between the Company and MorphoSys AG

Exhibit 10.30 ***Certain identified information has been excluded from the exhibit because it both (i) is not material and (ii) is the type that the company treats as private or confidential. Such omitted information is indicated by brackets (“[...***...]”) in this exhibit.*** Xencor, Inc. 111 West Lemon Avenue Monrovia, CA 91016 Attn: Bassil Dahiyat, CEO Fax: +1 626 305 0350 Copy: Morisson & fore

February 27, 2025 EX-10.7

Form of Restricted Stock Unit Agreement

Exhibit 10.7 Xencor, Inc. 2023 Equity Incentive Plan Restricted Stock Unit Award Agreement Pursuant to the Restricted Stock Unit Grant Notice (the “Grant Notice”) and this Restricted Stock Unit Award Agreement (the “Agreement”), Xencor, Inc. (the “Company”) has awarded you (“Participant”) an RSU Award (the “Award”) pursuant to Section 5 of the Company’s 2023 Equity Incentive Plan (the “Plan”) for

February 27, 2025 EX-10.29

Collaboration and License Agreement, dated June 27, 2010, by and between the Company and MorphoSys AG

Exhibit 10.29 ***Certain identified information has been excluded from the exhibit because it both (i) is not material and (ii) is the type that the company treats as private or confidential. Such omitted information is indicated by brackets (“[...***...]”) in this exhibit.*** CONFIDENTIAL Execution Copy COLLABORATION AND LICENSE AGREEMENT This COLLABORATION AND LICENSE AGREEMENT (this “Agreement”

February 27, 2025 EX-4.3

Description of

Exhibit 4.3 DESCRIPTION OF SECURITIES The following is a summary description of the material terms of capital stock of Xencor, Inc. (we, our or us), as well as other material terms of our amended and restated certificate of incorporation (Certificate of Incorporation) and our second amended and restated bylaws (Bylaws) and certain provisions of the DGCL. This summary does not purport to be complet

February 27, 2025 EX-10.34

Research and License Agreement effective September 15, 2015 between the Company and Amgen Inc

EXHIBIT 10.34 ***Certain identified information has been excluded from the exhibit because it both (i) is not material and (ii) is the type that the company treats as private or confidential. Such omitted information is indicated by brackets (“[...***...]”) in this exhibit.*** CONFIDENTIAL EXECUTION VERSION RESEARCH AND LICENSE AGREEMENT This Research and License Agreement (the “Agreement”) is ent

February 27, 2025 EX-99.1

Xencor Reports Fourth Quarter and Full Year 2024 Financial Results

Exhibit 99.1 Xencor Reports Fourth Quarter and Full Year 2024 Financial Results PASADENA, Calif.-(BUSINESS WIRE)-Feb. 27, 2025- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and autoimmune diseases, today reported financial results for the fourth quarter and full year ended December 31, 2024 and provided clinical

February 24, 2025 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K/A (Amendment No. 1) (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 o TRANSI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K/A (Amendment No.

February 24, 2025 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commis

February 24, 2025 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to C

February 24, 2025 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commi

February 13, 2025 8-K

Financial Statements and Exhibits, Non-Reliance on Previously Issued Financial Statements or a Related Audit Report or Completed Interim Review

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 7, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Numb

February 13, 2025 EX-7.1

om RSM US LLP, dated February 13, 2025.

44 Montgomery St Suite 3900 San Francisco, CA 94104 T +1 415 848 5300 F +1 415 848 5353 www.rsmus.com February 13, 2025 Securities and Exchange Commission Washington, D.C. 20549 Commissioners: We have read Xencor, Inc.’s statements included under Item 4.02(b) of its Form 8-K filed on February 13, 2025, and we agree with such statements regarding communications from our firm.

January 13, 2025 EX-99.1

® Proteins by Design® XmAb® Antibody Therapeutics Corporate Overview January 2025 2 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward- looking statements wit

® Proteins by Design® XmAb® Antibody Therapeutics Corporate Overview January 2025 2 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward- looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

January 13, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Numb

November 14, 2024 SC 13G/A

XNCR / Xencor, Inc. / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4) Xencor, Inc. (Name of Issuer) Common Stock, par value $0.01 (Title of Class of Securities) 98401F105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whic

November 12, 2024 SC 13G/A

XNCR / Xencor, Inc. / PRIMECAP MANAGEMENT CO/CA/ - PRIMECAP MANAGEMENT CO/CA/ Passive Investment

SC 13G/A 1 xncra16111124.htm PRIMECAP MANAGEMENT CO/CA/ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 16)* Xencor, Inc. (Name of Issuer) COM (Title of Class of Securities) 98401F105 (CUSIP Number) September 30, 2024 (Date of Event which Requires Filing of this Statement) Check the appropriate box to des

November 6, 2024 EX-99.1

Xencor Reports Third Quarter 2024 Financial Results

Exhibit 99.1 Xencor Reports Third Quarter 2024 Financial Results PASADENA, Calif- Nov. 6, 2024- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today reported financial results for the third quarter ended September 30, 2024 and provided a review of recent business and clinical-stage prog

November 6, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 6, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Numb

November 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

October 21, 2024 SC 13G

ZBIO / Zenas BioPharma, Inc. / Xencor Inc - SC 13G Passive Investment

SC 13G 1 zenasbiopharmainc-xencorsc.htm SC 13G SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Zenas BioPharma, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 98937L105 (CUSIP Number) September 16, 2024 (Date of Event Which Requires Filing of this Statement) Check the ap

October 18, 2024 SC 13G/A

XNCR / Xencor, Inc. / STATE STREET CORP Passive Investment

SC 13G/A 1 XencorInc.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* XENCOR INC (Name of Issuer) COMMON STOCK (Title of Class of Securities) 98401F105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursuant to which this S

October 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 30, 2024 XENCOR, INC. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 30, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Nu

October 4, 2024 EX-99.1

Xencor Announces Upcoming Change to Board of Directors

Exhibit 99.1 Xencor Announces Upcoming Change to Board of Directors PASADENA, Calif.- Oct. 4, 2024- Xencor, Inc. (NASDAQ: XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today announced that Dagmar Rosa-Bjorkeson has informed the Company that she will not stand for reelection to the Company’s Board of Direct

October 2, 2024 SC 13G/A

INMB / INmune Bio, Inc. / Xencor Inc - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

September 12, 2024 EX-4.1

Form of Pre-Funded Warrant to Purchase Common Stock.

Exhibit 4.1 FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [ ] (subject to adjustment) Warrant No. Original Issue Date: September [ ], 2024 XENCOR, INC. Xencor, Inc., a [Delaware] corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [Investor Name] or its registered assigns (the

September 12, 2024 EX-1.1

Underwriting Agreement, dated September 10, 2024, by and among Xencor, Inc. and Leerink Partners LLC, Raymond James & Associates, Inc. and RBC Capital Markets, LLC, as representatives of the underwriters named therein.

Exhibit 1.1 XENCOR, INC. (a Delaware corporation) 6,635,112 Shares of Common Stock Pre-Funded Warrants to Purchase up to 3,088,888 Shares of Common Stock UNDERWRITING AGREEMENT September 10, 2024 Leerink Partners LLC Raymond James & Associates, Inc. RBC Capital Markets, LLC as Representatives of the several Underwriters c/o Leerink Partners LLC 255 California St., 5th Floor San Francisco, CA 94111

September 12, 2024 424B5

6,635,112 Shares of Common Stock Pre-Funded Warrants to Purchase up to 3,088,888 Shares of Common Stock

Filed pursuant to Rule 424(b)(5) Registration No. 333-270030 PROSPECTUS SUPPLEMENT (To Prospectus dated February 27, 2023) 6,635,112 Shares of Common Stock Pre-Funded Warrants to Purchase up to 3,088,888 Shares of Common Stock We are offering 6,635,112 shares of our common stock, par value $0.01 per share, and, in lieu of offering shares of our common stock to certain investors who so choose, pre-

September 12, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Nu

September 12, 2024 EX-99.2

Xencor Announces Pricing of $175 Million Public Offering of Common Stock

Exhibit 99.2 Xencor Announces Pricing of $175 Million Public Offering of Common Stock PASADENA, Calif. – Sept. 11, 2024 – Xencor, Inc. (“Xencor”) (Nasdaq: XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today announced the pricing of its underwritten public offering of (i) 6,635,112 shares of its common stoc

September 12, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 10, 2024 Xencor, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Nu

September 12, 2024 EX-99.1

Xencor Announces Closing of Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares

Xencor Announces Closing of Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares PASADENA, Calif.

September 12, 2024 EX-99.1

Xencor Announces Proposed Public Offering of Common Stock

Exhibit 99.1 Xencor Announces Proposed Public Offering of Common Stock PASADENA, Calif. – Sept. 10, 2024 – Xencor, Inc. (“Xencor”) (Nasdaq: XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today announced that it has commenced an underwritten public offering of shares of its common stock, or, in lieu of commo

September 12, 2024 EX-FILING FEES

Table 1: Newly Registered and Carry Forward Securities

Calculation of Filing Fee Tables S-3 Xencor Inc Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to be Paid 1 Equity Common Stock, par value $0.

September 10, 2024 424B5

Subject to Completion, Dated SEPTEMBER 10, 2024

Filed pursuant to Rule 424(b)(5) Registration No. 333-270030 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying base prospectus are not an offer to sell these securities, a

September 9, 2024 EX-99.1

® Xencor R&D Strategy Call September 9, 2024 2 Today’s Agenda Overview Rationale for bispecific antibodies in autoimmune & inflammatory diseases New pipeline programs: B-cell depleting T-cell engagers Plamotamab (CD20 x CD3) XmAb657 (CD19 x CD3) New

® Xencor R&D Strategy Call September 9, 2024 2 Today’s Agenda Overview Rationale for bispecific antibodies in autoimmune & inflammatory diseases New pipeline programs: B-cell depleting T-cell engagers Plamotamab (CD20 x CD3) XmAb657 (CD19 x CD3) New pipeline programs: TL1A portfolio XmAb942 (Xtend TL1A) XmAb TL1A x IL-23 Potential first-in-class T-Cell engagers in solid tumor oncology XmAb819 (ENPP3 x CD3) XmAb808 (B7-H3 x CD28) 3 Forward Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

September 9, 2024 EX-99.2

Xencor Announces XmAb Drug Candidates in Autoimmune Disease with Near-Term Clinical Plans and Shares Clinical Progress in Early-Stage Oncology Programs -- Phase 1 healthy volunteer study of half-life extended anti-TL1A antibody XmAb942 to dose first

Xencor Announces XmAb Drug Candidates in Autoimmune Disease with Near-Term Clinical Plans and Shares Clinical Progress in Early-Stage Oncology Programs - Phase 1 healthy volunteer study of half-life extended anti-TL1A antibody XmAb942 to dose first subject in Q4 2024, with data anticipated in the first half of 2025 - - XmAb® T-cell engagers plamotamab (CD20 x CD3) and XmAb657 (CD19 x CD3) to be evaluated in autoimmune diseases, with respective Phase 1b/2a and Phase 1 studies to initiate in 2025 - - Ongoing Phase 1 dose escalation of XmAb819 (ENPP3 x CD3) in advanced clear cell renal cell carcinoma shows initial encouraging clinical activity including RECIST responses - - Management hosting webcast and conference call at 8:00 a.

September 9, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or Other Jurisdiction of Incorporation) (Commission File Num

August 5, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number

August 5, 2024 EX-10.1

Consulting Agreement by and between the Company and John J. Kuch, dated April 19, 2024.

Exhibit 10.1 XENCOR, INC. CONSULTING AGREEMENT Effective Date: April 19, 2024 This Consulting Agreement (the “Agreement”) is made as of the Effective Date set forth above by and between Xencor, Inc. (“Client”) and the consultant named on the signature page hereto (“Consultant”). WHEREAS, Client and Consultant entered into and agreed to a consulting arrangement on April [x], 2024 for Consultant to

August 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 5, 2024 EX-99.1

Xencor Reports Second Quarter 2024 Financial Results

Exhibit 99.1 Xencor Reports Second Quarter 2024 Financial Results PASADENA, Calif.-Aug. 5, 2024- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today reported financial results for the second quarter ended June 30, 2024 and provided a review of recent business updates and internal clini

August 5, 2024 EX-10.2

by and between the Company and Nancy Valente

Executive Employment Letter Addendum #2 Whereas, Nancy Valente (“Executive”) is employed by Xencor, Inc.

June 14, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

June 13, 2024 EX-99.1

Xencor Regains CD20 x CD3 Bispecific T-Cell Engager

Exhibit 99.1 Xencor Regains CD20 x CD3 Bispecific T-Cell Engager PASADENA, Calif.-June 13, 2024- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, announced it will regain exclusive worldwide rights to plamotamab, a CD20 x CD3 bispecific T-cell engager, which Xencor advanced through Phase

June 13, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

May 9, 2024 EX-10.4

Fourth Amendment to the License Agreement by and between the Company and MorphoSys AG (incorporated by reference to Exhibit 10.4 to the Company’s Quarterly Report on Form 10-Q, filed with the SEC on May 9, 2024).

Fourth AMENDMENT TO THE LICENSE AGREEMENT BY AND BETWEEN XENCOR, INC. AND MorphoSys AG This fourth amendment ("Amendment") to the COLLABORATION AND LICENSE AGREEMENT dated June 27, 2010, as amended on March 23, 2012, on January 8, 2020 and on July 13, 2020 (collectively, the “Agreement”), by and between XENCOR, INC., a Delaware corporation with its principal offices at 465 N. Halstead Street, Suit

May 9, 2024 EX-10.3

by and between the Company and

Exhibit 10.3 April 7, 2023 Dr. Nancy Valente Dear Dr. Valente, Congratulations! I am pleased to confirm our contingent offer of a position as Executive Vice President & Chief Development Officer, reporting to Bassil Dahiyat, CEO and starting on May 1, 2023 or another mutually agreeable date (“Start Date”). This position’s primary location is Pasadena, CA. The specifics of this offer are as follows

May 9, 2024 EX-99.1

Xencor Reports First Quarter 2024 Financial Results

Exhibit 99.1 Xencor Reports First Quarter 2024 Financial Results PASADENA, Calif.-May 9, 2024- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today reported financial results for the first quarter ended March 31, 2024 and provided a review of recent clinical and business highlights. “We

May 9, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number) (

May 9, 2024 EX-10.2

Employment Agreement dated March 11, 2024 by and between the Company and Bart Jan Cornelissen.

Exhibit 10.2 March 11, 2024 Bart Cornelissen 7614 Overlake Drive W Medina, WA 98039 Dear Bart Cornelissen, Congratulations! I am pleased to confirm our contingent offer of a position as Senior Vice President & Chief Financial Officer, reporting to Bassil Dahiyat, CEO and starting on April 9, 2024 or another mutually agreeable date (the “Start Date”). This position’s location is Remote in the state

May 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 9, 2024 EX-10.1

between the Company and A

THIRD AMENDMENT TO LEASE (465 North Halstead) THIS THIRD AMENDMENT TO LEASE (“Third Amendment”) is made and entered into as of the 26th day of January, 2024, by and between AG-LC 465 NORTH HALSTEAD OWNER, L.

April 24, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy State

April 24, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy State

April 9, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 9, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

April 9, 2024 EX-99.1

Xencor Appoints Bart Cornelissen as Chief Financial Officer

Exhibit 99.1 Xencor Appoints Bart Cornelissen as Chief Financial Officer PASADENA, Calif. - April 9, 2024 - Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and other serious diseases, today announced the appointment of Bart Cornelissen to senior vice president and chief financial officer. Mr. Cornelissen has more t

March 6, 2024 EX-99

® Proteins by Design® XmAb® Antibody Therapeutics Corporate Overview March 2024 2 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward- looking statements withi

® Proteins by Design® XmAb® Antibody Therapeutics Corporate Overview March 2024 2 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, may constitute forward- looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

March 6, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 6, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

February 29, 2024 EX-97

Xencor, Inc. Compensation R

Exhibit 97 XENCOR, INC. COMPENSATION RECOVERY POLICY Adopted as of September 15, 2023 Xencor, Inc., a Delaware corporation (the “Company”), has adopted a Compensation Recovery Policy (this “Policy”) as described below. 1.Overview The Policy sets forth the circumstances and procedures under which the Company shall recover Erroneously Awarded Compensation from current and former Executive Officers o

February 29, 2024 EX-10.47

Amended and Restated Collaboration and License Agreement, executed on November 14, 2023 and effective as of June 1, 2024, by and between the Company and Genentech, Inc. and F. Hoffmann-La Roche Ltd (incorporated by reference in Exhibit 10.4

Exhibit 10.47 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE XENCOR, INC. HAS DETERMINED THE INFORMATION (I) IS NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO XENCOR, INC. IF PUBLICLY DISCLOSED. CONFIDENTIAL EXECUTION COPY AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT BY AND BETWEEN, on the one hand, XENCOR, INC., AND

February 29, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 o TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36182 Xencor, Inc.

February 27, 2024 EX-99.1

Xencor Reports Fourth Quarter and Full Year 2023 Financial Results -- Clinical development focus on high-potential XmAb® T cell engagers and selective dual checkpoint inhibitor, vudalimab -- -- Vudalimab (PD-1 x CTLA-4) monotherapy generally well tol

Exhibit 99.1 Xencor Reports Fourth Quarter and Full Year 2023 Financial Results - Clinical development focus on high-potential XmAb® T cell engagers and selective dual checkpoint inhibitor, vudalimab - - Vudalimab (PD-1 x CTLA-4) monotherapy generally well tolerated with encouraging clinical benefit for patients with high-risk mCRPC who have advanced beyond standard of care therapy - - Management

February 27, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2024 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Num

February 14, 2024 SC 13G/A

XNCR / Xencor, Inc. / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3) Xencor, Inc. (Name of Issuer) Common Stock, par value $0.01 (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 13, 2024 SC 13G/A

XNCR / Xencor, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv02311-xencorinc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 6)* Name of issuer: Xencor Inc Title of Class of Securities: Common Stock CUSIP Number: 98401F105 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to designate the rule purs

February 12, 2024 SC 13G/A

XNCR / Xencor, Inc. / PRIMECAP MANAGEMENT CO/CA/ - PRIMECAP MANAGEMENT CO/CA/ Passive Investment

SC 13G/A 1 xncra1521224.htm PRIMECAP MANAGEMENT CO/CA/ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 15)* Xencor, Inc. (Name of Issuer) COM (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to desig

November 15, 2023 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Num

November 8, 2023 EX-10.1

Executive Employment Agreement Addendum dated November 7, 2023 by and between the Company and Celia Eckert (incorporated by reference in Exhibit 10.1 to the Company's Form 10-Q filed with the SEC on November 8, 2023).

Exhibit 10.1 Executive Employment Agreement Addendum Whereas, Employee is employed by Xencor as its Senior Vice President, General Counsel & Corporate Secretary and Employee is subject to an Employment Letter, dated August 5, 2019 a copy of which is attached as Attachment 1 (“Employment Letter”); Whereas, under the Employment Letter, Employee is entitled to certain severance benefits in connection

November 8, 2023 EX-10.2

Executive Employment Agreement Addendum dated November 7, 2023 by and between the Company and Nancy Valente (incorporated by reference in Exhibit 10.2 to the Company's Form 10-Q filed with the SEC on November 8, 2023).

Exhibit 10.2 Executive Employment Agreement Addendum Whereas, Employee is employed by Xencor as its Executive Vice President & Chief Development Officer and Employee is subject to an Employment Letter, dated April 7, 2023 a copy of which is attached as Attachment 1 (“Employment Letter”); Whereas, under the Employment Letter, Employee is entitled to certain severance benefits in connection with a T

November 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 7, 2023 EX-10.1

Royalty Purchase Agreement, entered into on November 3, 2023, by and between Xencor, Inc. and OCM Life Sciences Portfolio LP (incorporated by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K, filed with the SEC on November 7, 2023).

EXECUTION VERSION CERTAIN CONFIDENTIAL INFORMATION (MARKED BY BRACKETS AS “[***] HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED ROYALTY PURCHASE AGREEMENT XENCOR, INC.

November 7, 2023 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Numb

November 7, 2023 EX-99.1

Xencor Sells Portion of Royalties and Milestones from Ultomiris® and Monjuvi® to OMERS Life Sciences for $215 Million

Exhibit 99.1 Xencor Sells Portion of Royalties and Milestones from Ultomiris® and Monjuvi® to OMERS Life Sciences for $215 Million PASADENA, Calif. – November 7, 2023 - Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced the sale of portions of financial interests

November 7, 2023 EX-10.2

Royalty Purchase Agreement, entered into on November 3, 2023, by and between Xencor, Inc. and OCM Life Sciences Portfolio LP (incorporated by reference to Exhibit 10.2 to the Company's Current Report on Form 8-K, filed with the SEC on November 7, 2023).

EXECUTION VERSION CERTAIN CONFIDENTIAL INFORMATION (MARKED BY BRACKETS AS “[***] HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED ROYALTY PURCHASE AGREEMENT (MONJUVI®/MINJUVI®) XENCOR, INC.

November 7, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Numb

November 7, 2023 EX-99.1

Xencor Reports Third Quarter 2023 Financial Results -- Royalty Transaction Generates $215 Million Upfront -- -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Third Quarter 2023 Financial Results - Royalty Transaction Generates $215 Million Upfront - - Management to Host Conference Call at 4:30 p.m. ET Today - PASADENA, Calif.-Nov. 7, 2023- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of patients with cancer and autoimmune diseases, tod

October 26, 2023 EX-99.1

Xencor Announces Planned Retirement of Chief Financial Officer John Kuch

Exhibit 99.1 Xencor Announces Planned Retirement of Chief Financial Officer John Kuch PASADENA, Calif. - Oct. 26, 2023 - Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, announced that John J. Kuch, senior vice president and chief financial officer, plans to retire in March 202

October 26, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 24, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Numb

September 19, 2023 EX-99.1

Xencor Appoints Barbara J. Klencke, M.D., to Board of Directors

Exhibit 99.1 Xencor Appoints Barbara J. Klencke, M.D., to Board of Directors PASADENA, Calif.-September 19, 2023- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced the appointment of Barbara J. Klencke, M.D., to its board of directors. Dr. Klencke has more than 2

September 19, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2023 XENCOR, INC. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Nu

August 3, 2023 EX-10.1

First Amendment to Collaboration and License Agreement, dated January 30, 2023, by and between the Company and Janssen Biotech, Inc.

Exhibit 10.1 [***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED WITH “[***]” TO INDICATE WHERE OMISSIONS HAVE BEEN MADE. FIRST AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT This First Amendment to the Collaboration and License Agreement (th

August 3, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 3, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number

August 3, 2023 EX-99.1

Xencor Reports Second Quarter 2023 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Second Quarter 2023 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - PASADENA, Calif.-August 3, 2023- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of patients with cancer and autoimmune diseases, today reported financial results for the second quarter

July 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2023 XENCOR, INC. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

June 16, 2023 S-8 POS

As filed with the Securities and Exchange Commission on June 15, 2023

As filed with the Securities and Exchange Commission on June 15, 2023 Registration Nos.

June 16, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES 2 xncr-20230615xsx8xexh107fi.htm EX-FILING FEES Calculation of Filing Fee Tables Form S-8 (Form Type) Xencor, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit(2) Maximum Aggregate Offering Price Fee Rate Amount of Regis

June 16, 2023 S-8

As filed with the Securities and Exchange Commission on June 15, 2023

As filed with the Securities and Exchange Commission on June 15, 2023 Registration No.

June 16, 2023 S-8 POS

As filed with the Securities and Exchange Commission on June 15, 2023

As filed with the Securities and Exchange Commission on June 15, 2023 Registration Nos.

June 16, 2023 S-8 POS

As filed with the Securities and Exchange Commission on June 15, 2023

As filed with the Securities and Exchange Commission on June 15, 2023 Registration Nos.

June 16, 2023 S-8 POS

As filed with the Securities and Exchange Commission on June 15, 2023

As filed with the Securities and Exchange Commission on June 15, 2023 Registration Nos.

June 15, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

May 8, 2023 EX-99.1

Xencor Reports First Quarter 2023 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports First Quarter 2023 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - PASADENA, Calif.-May 8, 2023- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of patients with cancer and autoimmune diseases, today reported financial results for the first quarter ende

May 8, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number) (

May 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 1, 2023 DEFR14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant Filed by a Party other than the Registrant Check the appropriate box: Preliminary Proxy Statement Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) Definitive Pro

April 26, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy State

April 26, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number

April 26, 2023 EX-99.1

Xencor, Inc. 2023 Equity Incentive Plan (incorporated herein by reference to Exhibit 99.1 to the Registrant’s Definitive Proxy Statement on Schedule 14A for the 2023 Annual Meeting of Stockholders of the Registrant, filed with the SEC on April 26, 2023).

xncr2023equityincentivep LEGALUSW # 115236691.3 1 XENCOR, INC. 2023 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: APRIL 20, 2023 APPROVED BY THE STOCKHOLDERS: [], 2023 1. GENERAL. (a) Plan Purpose. The Company, by means of the Plan, seeks to secure and retain the services of Employees, Directors and Consultants, to provide incentives for such persons to exert maximum efforts for the suc

April 26, 2023 EX-99.1

Xencor Appoints Nancy Valente, M.D., as Chief Development Officer

Exhibit 99.1 Xencor Appoints Nancy Valente, M.D., as Chief Development Officer PASADENA, Calif. - April 26, 2023 - Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced the appointment of Nancy Valente, M.D., to Executive Vice President, Chief Development Officer. Dr

April 26, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy State

March 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 XENCOR, INC. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number

February 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2023 XENCOR, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Num

February 27, 2023 EX-4.4

Form of Senior Indenture.

Exhibit 4.4 XENCOR, INC. SENIOR DEBT SECURITIES INDENTURE Dated as of Trustee TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificate 7 Section 2.03 Denominations: Provisions

February 27, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 o TRANSITION REPORT PURSUANT

Table of Contents` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36182 Xencor, Inc.

February 27, 2023 EX-3.2

Amended and Restated Bylaws of the Company (incorporated by reference to Exhibit 3.2 to the Company’s Annual Report on Form 10-K, filed with the SEC on February 27, 2023).

SECOND AMENDED AND RESTATED BYLAWS OF XENCOR, INC. (A DELAWARE CORPORATION) Table Of Contents Page ARTICLE I Offices 1 Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II Corporate Seal 1 Section 3. Corporate Seal 1 ARTICLE III Stockholders’ Meetings 1 Section 4. Place of Meetings 1 Section 5. Annual Meetings 1 Section 6. Special Meetings 4 Section 7. Notice of Meetings 5 Section

February 27, 2023 EX-10.42

First Amendment to Option and License Agreement dated June14, 2019 by and between the Company and Alexion Pharma Holding (as successor to Alexion Pharmaceuticals, Inc.)

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED AND HAS BEEN MARKED WITH “[***]” TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

February 27, 2023 EX-10.39

Sixth Amendment to Lease, dated November 14, 2022, by and between the Company and 111 Lemon Investors LLC (incorporated by reference to Exhibit 10.39 to the Company's Form 10-K filed with the SEC on February 27, 2023).

SIXTH AMENDMENT TO LEASE This SIXTH AMENDMENT TO LEASE (this “Amendment”) is made and effective as of October 18, 2022 (the “Effective Date”) by and between 111 LEMON INVESTORS LLC, a California limited liability company successor-in-interest to BF Monrovia, LLC, a California limited liability company (“Landlord”) and XENCOR, INC.

February 27, 2023 S-3ASR

As filed with the Securities and Exchange Commission on February 27, 2023

As filed with the Securities and Exchange Commission on February 27, 2023 Registration No.

February 27, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3ASR (Form Type) Xencor, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title(1) Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carr

February 27, 2023 EX-1.2

Sales Agreement dated February 27, 2023 by and between the Registrant and SVB Securities LLC (incorporated by reference in Exhibit 1.2 to the Company's Form S-3ASR filed with the SEC on February 27, 2023).

Exhibit 1.2 XENCOR, INC. Shares of Common Stock ($0.01 par value per share) SALES AGREEMENT February 27, 2023 SVB SECURITIES LLC 1301 Avenue of the Americas, 12th Floor New York, New York 10019 Ladies and Gentlemen: Xencor, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with SVB Securities LLC (the “Agent”), as follows: 1. Issuance and Sale of Shares. The C

February 27, 2023 EX-10.40

Xencor, Inc. Amended and Restated Non-Employee Director Compensation Policy (incorporated by reference to Exhibit 10.40 to the Company's Form 10-K filed with the SEC on February 27, 2023).

Approved September 8, 2022 Xencor, Inc. Amended and Restated Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) who is a member as of July 1, 2021 (the “Effective Date”) and who is not also serving as an employee of Xencor, Inc. (“Xencor”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this

February 27, 2023 EX-10.43

Second Amendment to Option and License Agreement dated November 28, 2022 by and between the Company and Alexion Pharma International Operations Limited (as successor to Alexion Pharmaceuticals, Inc.) (incorporated by reference to Exhibit 10.43 to the Company's Form 10-K filed with the SEC on February 27, 2023).

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED AND HAS BEEN MARKED WITH “[***]” TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

February 27, 2023 EX-4.5

Form of Subordinated Indenture.

Exhibit 4.5 XENCOR, INC. SUBORDINATED DEBT SECURITIES INDENTURE Dated as of Trustee TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificate 7 Section 2.03 Denominations: Prov

February 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 23, 2023 XENCOR, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 23, 2023 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Num

February 23, 2023 EX-99.1

Xencor Reports Fourth Quarter and Full Year 2022 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Fourth Quarter and Full Year 2022 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - MONROVIA, Calif.-Feb. 23, 2023- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the fourth quarter

February 15, 2023 SC 13G

INMB / INmune Bio Inc. Common stock / Xencor Inc - SC 13G Passive Investment

SC 13G 1 inmunebioinc-xencorsc13g20.htm SC 13G SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* INmune Bio, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 45782T105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropri

February 13, 2023 SC 13G/A

XNCR / Xencor Inc / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) Xencor, Inc. (Name of Issuer) Common Stock, par value $0.01 (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 9, 2023 SC 13G/A

XNCR / Xencor Inc / PRIMECAP MANAGEMENT CO/CA/ - PRIMECAP MANAGEMENT CO/CA/ Passive Investment

SC 13G/A 1 xncra1420923.htm PRIMECAP MANAGEMENT CO/CA/ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 14)* Xencor, Inc. (Name of Issuer) COM (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to desig

February 9, 2023 SC 13G/A

XNCR / Xencor Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv02279-xencorinc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 5)* Name of issuer: Xencor Inc. Title of Class of Securities: Common Stock CUSIP Number: 98401F105 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pur

December 8, 2022 SC 13G/A

XNCR / Xencor Inc / PRIMECAP MANAGEMENT CO/CA/ - PRIMECAP MANAGEMENT CO/CA/ Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 13)* Xencor, Inc. (Name of Issuer) COM (Title of Class of Securities) 98401F105 (CUSIP Number) November 30, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

November 7, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 7, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2022 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commis

November 7, 2022 EX-99.1

Xencor Reports Third Quarter 2022 Financial Results -- XmAb564, engineered IL-2 cytokine, is well-tolerated and generates a durable, dose-dependent and selective expansion of Tregs in single-dose, healthy volunteer study -- -- Management to host conf

Exhibit 99.1 ? Xencor Reports Third Quarter 2022 Financial Results - XmAb564, engineered IL-2 cytokine, is well-tolerated and generates a durable, dose-dependent and selective expansion of Tregs in single-dose, healthy volunteer study - - Management to host conference call at 4:30 p.m. ET Today - MONROVIA, Calif.- Nov. 7, 2022- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company

November 7, 2022 EX-99.2

2 Speakers Bassil Dahiyat, Ph.D. President Chief Executive Officer Director John Kuch Senior Vice President & Chief Financial Officer John Desjarlais, Ph.D. Senior Vice President Chief Scientific Officer Allen Yang, M.D., Ph.D. Senior Vice President

Exhibit 99.2 ? Xencor Q3 2022 Financial Results XmAb?564 Data Presentation November 7, 2022 2 Speakers Bassil Dahiyat, Ph.D. President Chief Executive Officer Director John Kuch Senior Vice President & Chief Financial Officer John Desjarlais, Ph.D. Senior Vice President Chief Scientific Officer Allen Yang, M.D., Ph.D. Senior Vice President Chief Medical Officer Ralph Zitnik, M.D. Executive Medical

November 7, 2022 EX-10.1

Second Amendment to Lease, dated August 2, 2022, by and between the Company and AG-LC 465 North Halstead Owner, L.P. (incorporated by reference to Exhibit 10.1 to the Company's Form 10-Q filed with the SEC on November 7, 2022).

Exhibit 10.1 SECOND AMENDMENT TO LEASE (465 North Halstead) THIS SECOND AMENDMENT TO LEASE (?Second Amendment?) is made and entered into as of the 2nd day of August, 2022, by and between AG-LC 465 NORTH HALSTEAD OWNER, L.P., a Delaware limited partnership (?Landlord?) and XENCOR, INC., a Delaware corporation (?Tenant?). R E C I T A L S: A.Landlord and Tenant entered into that certain Lease dated a

September 9, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K ? CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 ? Date of Report (Date of earliest event reported): September 9, 2022 XENCOR, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission

September 9, 2022 EX-99.1

Xencor Appoints Nancy Valente, M.D., to Board of Directors

Exhibit 99.1 ? Xencor Appoints Nancy Valente, M.D., to Board of Directors MONROVIA, Calif.-September 9, 2022- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced the appointment of Nancy Valente, M.D., to its board of directors. Dr. Valente has more than 20 years o

August 3, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2022 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commissi

August 3, 2022 S-8

As filed with the Securities and Exchange Commission on August 3, 2022

As filed with the Securities and Exchange Commission on August 3, 2022 Registration No.

August 3, 2022 EX-99.1

Xencor Reports Second Quarter 2022 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Second Quarter 2022 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - MONROVIA, Calif.-August 3, 2022- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the second quarter ended June 30

August 3, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

August 3, 2022 EX-10.1

First Amendment to Office Lease, dated May 19, 2022, by and between the Company and PRII High Bluffs LLC and Collins Corporate Center Partners, LLC (incorporated by reference to Exhibit 10.1 to the Company's Form 10-Q filed with the SEC on August 3, 2022).

? Exhibit 10.1 FIRST AMENDMENT TO OFFICE LEASE This First Amendment to Office Lease (this ?First Amendment?) is made and entered into by and between PRII HIGH BLUFFS, LLC, a Delaware limited liability company and COLLINS CORPORATE CENTER PARTNERS, LLC, a Delaware limited liability company, as tenants in common (collectively, ?Landlord?), and XENCOR, INC., a Delaware corporation (?Tenant?), to be e

August 3, 2022 EX-FILING FEES

Filing Fee Table

? Calculation of Filing Fee Tables Form S-8 (Form Type) Xencor, Inc. (Exact Name of Registrant as Specified in its Charter) ? Table 1: Newly Registered Securities ? ? ? ? ? (1) ? ? ? (2)? ? ? ? ? ? (5)? ? Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit(2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee(5) Eq

June 28, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K ? CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 ? Date of Report (Date of earliest event reported): June 23, 2022 XENCOR, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File

May 5, 2022 EX-99.1

Xencor Reports First Quarter 2022 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports First Quarter 2022 Financial Results ? - Management to Host Conference Call at 4:30 p.m. ET Today - ? MONROVIA, Calif.-May 5, 2022- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the first quarter ended March 31

May 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

May 5, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2022 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commission

April 27, 2022 DEF 14A

the portions of the Definitive Proxy Statement on Schedule 14A for the 2022 Annual Meeting of Stockholders of the Registrant, filed with the Commission on April 27, 2022, that are specifically incorporated by reference into Part III of the 2021 Form 10-K; and

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

April 27, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? SCHEDULE 14A ? Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? ? ? Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definiti

February 24, 2022 EX-10.38

Xencor, Inc. Amended and Restated Non-Employee Director Compensation Policy.

Exhibit 10.38 Xencor, Inc. Amended and Restated Non-Employee Director Compensation Policy ? Each member of the Board of Directors (the ?Board?) who is a member as of July 1, 2021 (the ?Effective Date?) and who is not also serving as an employee of Xencor, Inc. (?Xencor?) or any of its subsidiaries (each such member, an ?Eligible Director?) will receive the compensation described in this Amended an

February 24, 2022 EX-10.39

Collaboration and License Agreement, dated October 1, 2021, by and between the Company and Janssen Biotech, Inc.

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

February 24, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K

Table of Contents ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ? ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to ? Commission file number: 001-36182 Xencor, Inc.

February 23, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 23, 2022 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commi

February 23, 2022 EX-99.1

Xencor Reports Fourth Quarter and Full Year 2021 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Fourth Quarter and Full Year 2021 Financial Results ? - Management to Host Conference Call at 4:30 p.m. ET Today - ? MONROVIA, Calif.-Feb. 23, 2021- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the fourth quar

February 14, 2022 SC 13G/A

XNCR / Xencor Inc / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Xencor, Inc. (Name of Issuer) Common Stock, par value $0.01 (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 10, 2022 SC 13G/A

INMB / INmune Bio Inc. Common stock / Xencor Inc - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 10, 2022 SC 13G/A

XNCR / Xencor Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 4)* Name of issuer: Xencor Inc. Title of Class of Securities: Common Stock CUSIP Number: 98401F105 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ??Rule 13

February 10, 2022 SC 13G/A

XNCR / Xencor Inc / PRIMECAP MANAGEMENT CO/CA/ - PRIMECAP MANAGEMENT CO/CA/ Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 12)* Xencor, Inc. (Name of Issuer) COM (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

November 8, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

November 8, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commis

November 8, 2021 EX-99.1

Xencor Reports Thirds Quarter 2021 Financial Results and Announces Encouraging Preliminary Data from Ongoing Phase 1 Study of Potency-reduced IL15-Fc Cytokine, XmAb306 -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Thirds Quarter 2021 Financial Results and Announces Encouraging Preliminary Data from Ongoing Phase 1 Study of Potency-reduced IL15-Fc Cytokine, XmAb306 ? - Management to Host Conference Call at 4:30 p.m. ET Today - ? MONROVIA, Calif.-Nov. 8, 2021- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cyto

October 4, 2021 EX-99.1

Xencor Enters Global Collaboration and License Agreement with Janssen to Advance Plamotamab and XmAb CD28 Bispecific Antibody Combinations for the Treatment of Patients with B-Cell Malignancies -- Second agreement with Janssen on bispecific antibodie

Exhibit 99.1 ? ? Xencor Enters Global Collaboration and License Agreement with Janssen to Advance Plamotamab and XmAb CD28 Bispecific Antibody Combinations for the Treatment of Patients with B-Cell Malignancies ? - Second agreement with Janssen on bispecific antibodies directed toward the CD28 co-stimulatory receptor on T cells - ? - Xencor to receive $100 million upfront payment and $25 million e

October 4, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K ? CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 ? Date of Report (Date of earliest event reported): October 1, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission Fi

August 4, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commissi

August 4, 2021 EX-10.1

Second Amendment to the Collaboration and License Agreement, dated June 30, 2021, by and between the Company and Genentech, Inc., and F. Hoffmann-La Roche LTD (incorporated by reference to Exhibit 10.1 to the Company’s Form 10-Q filed with the SEC on August 4, 2021).

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

August 4, 2021 EX-10.2

Agreement of Lease, dated April 30, 2021, by and between the Company and Angelo Gordon Real Estate, Inc. (incorporated by reference to Exhibit 10.2 to the Company’s Form 10-Q filed with the SEC on August 4, 2021).

? Exhibit 10.2 ? AGREEMENT OF LEASE (465 North Halstead) THIS AGREEMENT OF LEASE (?Agreement?) is made and entered into as of the 30th day of April, 2021, by and between ANGELO GORDON REAL ESTATE, INC., a Delaware corporation (?AG?) and XENCOR, INC., a Delaware corporation (?Xencor?). R E C I T A L S: A.AG (as buyer) has entered into a purchase and sale agreement (the ?Purchase Agreement?) with No

August 4, 2021 EX-10.3

First Amendment to Lease, dated July 13, 2021, by and between the Company and Angelo Gordon Real Estate, Inc. (incorporated by reference to Exhibit 10.3 to the Company’s Form 10-Q filed with the SEC on August 4, 2021).

Exhibit 10.3 ? FIRST AMENDMENT TO LEASE This FIRST AMENDMENT TO LEASE ("Amendment") is made and entered into as of July 13, 2021, by and between AG-LC 465 NORTH HALSTEAD OWNER, L.P., a Delaware limited partnership ("Landlord"), and XENCOR, INC., a Delaware corporation ("Tenant"). r e c i t a l S: A.ANGELO GORDON REAL ESTATE, INC., a Delaware corporation (?Original Landlord?) and Tenant entered int

August 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

August 4, 2021 EX-99.1

Xencor Reports Second Quarter 2021 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Second Quarter 2021 Financial Results ? - Management to Host Conference Call at 4:30 p.m. ET Today - ? MONROVIA, Calif.-August 4, 2021- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the second quarte

July 6, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K ? CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 ? Date of Report (Date of earliest event reported): June 30, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File

June 28, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K ? CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 ? Date of Report (Date of earliest event reported): June 24, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File

May 5, 2021 EX-99.1

Xencor Reports First Quarter 2021 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports First Quarter 2021 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - MONROVIA, Calif.-May 5, 2021- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the first quarter ended M

May 5, 2021 10-Q

Quarterly Report - 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

May 5, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number) (

May 5, 2021 EX-10.1

First Amendment to the Collaboration and License Agreement, dated March 10, 2021, by and between the Company and Genentech, Inc. and F. Hoffmann-La Roche LTD (incorporated by reference to Exhibit 10.1 to the Company’s Form 10-Q filed with the SEC on May 5, 2021).

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

April 28, 2021 DEFA14A

- DEFA14A

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? SCHEDULE 14A ? Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? ? ? Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definiti

April 28, 2021 DEF 14A

- DEF 14A

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

March 10, 2021 EX-10.1

Form of Restricted Stock Unit Agreement (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, filed with the SEC on March 10, 2021).

Exhibit 10.1 Xencor, Inc. 2013 Equity Incentive Plan Restricted Stock Unit Award Agreement ? Pursuant to the Restricted Stock Unit Grant Notice (the ?Grant Notice?) and this Restricted Stock Unit Award Agreement (the ?Agreement?), Xencor, Inc. (the ?Company?) has awarded you (?Participant?) a Restricted Stock Unit Award (the ?Award?) pursuant to Section 6(b) of the Company?s 2013 Equity Incentive

March 10, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 5, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Number)

February 24, 2021 10-K

Annual Report - 10-K

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ? ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to ? Commission file number: 001-36182 Xencor, Inc.

February 24, 2021 EX-10.32

Third Amendment to the License Agreement, dated July 13, 2020, by and between the Company and MorphoSys AG (incorporated by reference to Exhibit 10.32 to the Company’s Form 10-K filed with the SEC on February 23, 2021).

? ? Execution Version CONFIDENTIAL ? Exhibit 10.32 THIRD AMENDMENT TO THE LICENSE AGREEMENT BY AND BETWEEN XENCOR, INC. AND MorphoSys AG This third amendment ("Amendment") to the COLLABORATION AND LICENSE AGREEMENT dated June 27, 2010, as amended on March 23, 2012, and on January 8, 2020 (such second amendment being wrongly named ?first amendment? thereunder shall be regarded and referred to as th

February 24, 2021 EX-10.33

Fifth Amendment to Lease, dated October 31, 2020, by and between the Company and 111 Lemon Investors LLC (incorporated by reference to Exhibit 10.33 to the Company’s Form 10-K filed with the SEC on February 23, 2021).

? Exhibit 10.33 FIFTH AMENDMENT TO LEASE This FIFTH AMENDMENT TO LEASE (this ?Amendment?) is made and effective as of October 31, 2020 (the ?Effective Date?) by and between 111 LEMON INVESTORS LLC, a California limited liability company successor-in-interest to BF Monrovia, LLC, a California limited liability company (?Landlord?) and XENCOR, INC., a Delaware corporation successor-in-interest to Xe

February 24, 2021 EX-10.34

Collaboration and License Agreement, dated December 4, 2020, by and between the Company and Janssen Biotech, Inc. (incorporated by reference to Exhibit 10.34 to the Company’s Form 10-K filed with the SEC on February 23, 2021).

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

February 24, 2021 EX-10.29

First Amendment to the Research and License Agreement, dated November 22, 2019, by and between the Company and Amgen Inc. (incorporated by reference to Exhibit 10.29 to the Company’s Form 10-K filed with the SEC on February 23, 2021).

Execution Version [***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

February 24, 2021 EX-10.31

Second Amendment to the License Agreement, dated January 8, 2020, by and between the Company and MorphoSys AG (incorporated by reference to Exhibit 10.31 to the Company’s Form 10-K filed with the SEC on February 23, 2021).

Execution Version ? Exhibit 10.31 First Amendment to the License Agreement By and Between Xencor, Inc. and MorphoSys AG This first amendment ("Amendment") to the Collaboration and License Agreement dated June 27, 2010 (the ?Agreement?) by and between Xencor, Inc., a Delaware corporation with its principal offices at 111 West Lemon Avenue, Monrovia, CA 91016 (?Xencor?), and MorphoSys AG, a German c

February 24, 2021 EX-10.30

Amendment to the Cross-License Agreement, dated January 2, 2020, by and between the Company and MedImmune, LLC.

[***] = CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE.

February 23, 2021 EX-99.1

Xencor Reports Fourth Quarter and Full Year 2020 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Fourth Quarter and Full Year 2020 Financial Results ? - Management to Host Conference Call at 4:30 p.m. ET Today - ? MONROVIA, Calif.-Feb. 23, 2021-Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported financial results for the f

February 23, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ? FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 23, 2021 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporation) (Commi

February 12, 2021 SC 13G/A

SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 11)* Xencor, Inc. (Name of Issuer) (Title of Class of Securities) (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement)

UNITED STATES OMB APPROVAL SECURITIES AND EXCHANGE COMMISSION OMB Number: 3235-0145 Washington, D.

February 10, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 3)*

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 3)* Name of issuer: Xencor Inc. Title of Class of Securities: Common Stock CUSIP Number: 98401F105 Date of Event Which Requires Filing of this Statement: December 31, 2020 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rule 13

January 22, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* INmune Bio Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) (CUSIP Number)

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

January 11, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Miragen Therapeutics, Inc. (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Se

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Miragen Therapeutics, Inc. (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 60463E 202 (CUSIP Number) December 16, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

December 7, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 4, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Numb

December 7, 2020 EX-99.1

Xencor Enters Collaboration with Janssen with Aim to Discover Novel CD28 Bispecific Antibodies for the Treatment of Prostate Cancer -- Research collaboration focused on the discovery of novel bispecific antibodies directed toward the CD28 co-stimulat

Exhibit 99.1 Xencor Enters Collaboration with Janssen with Aim to Discover Novel CD28 Bispecific Antibodies for the Treatment of Prostate Cancer - Research collaboration focused on the discovery of novel bispecific antibodies directed toward the CD28 co-stimulatory receptor and an undisclosed prostate tumor target - - Xencor receives $50 million upfront payment and is eligible to receive potential

November 30, 2020 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 24, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) ? ? ? ? ? ? ? ? ? ? Delaware 001-36182 ? 20-1622502 ? (State or other jurisdiction of incorporati

November 6, 2020 EX-10.1

Xencor, Inc. Amended and Restated Non-Employee Director Compensation Policy (incorporated by reference to Exhibit 10.1 to the Company’s Form 10-Q filed with the SEC on November 6, 2020).

Exhibit 10.1 Xencor, Inc. Amended and Restated Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) who is a member as of July 1, 2020 (the “Effective Date”) and who is not also serving as an employee of Xencor, Inc. (“Xencor”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Amended and R

November 6, 2020 10-Q

Quarterly Report - 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 6, 2020 EX-10.2

Fourth Amendment to Lease, dated September 30, 2020, by and between the Company and 111 Lemon Investors LLC (incorporated by reference to Exhibit 10.2 to the Company’s Form 10-Q filed with the SEC on November 6, 2020).

Exhibit 10.2 FOURTH AMENDMENT TO LEASE This FOURTH AMENDMENT TO LEASE (this “Amendment”) is made and effective as of September 30, 2020 (the “Effective Date”) by and between 111 LEMON INVESTORS LLC, a California limited liability company successor-in-interest to BF Monrovia, LLC, a California limited liability company (“Landlord”) and XENCOR, INC., a Delaware corporation successor-in-interest to X

November 5, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State or other jurisdiction of incorporation) (Commission File Numb

November 5, 2020 EX-99.1

Xencor Reports Third Quarter 2020 Financial Results -- Management to Host Conference Call at 4:30 p.m. EST Today --

Exhibit 99.1 Xencor Reports Third Quarter 2020 Financial Results - Management to Host Conference Call at 4:30 p.m. EST Today - MONROVIA, Calif.-Nov. 5, 2020- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer and autoimmune diseases, today reported financial results for the third quarter ended September 30,

October 14, 2020 EX-99.1

Escalation (n = 37)

Exhibit 99.1 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors Background XmAb20717 is a humanized bispecific monoclonal antibody that simultaneously targets PD-1 and CTLA-4. We report preliminary data from an ongoing, multicenter, Phase 1 study investigating the safety/tolerabilit

October 14, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 14, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State of incorporation) (Commission File No.) (IRS Employer Identif

September 10, 2020 SC 13G/A

XNCR / Xencor, Inc. / PRIMECAP MANAGEMENT CO/CA/ - SC 13G/A Passive Investment

UNITED STATES OMB APPROVAL SECURITIES AND EXCHANGE COMMISSION OMB Number: 3235-0145 Washington, D.

September 8, 2020 SC 13G/A

XNCR / Xencor, Inc. / PRIMECAP MANAGEMENT CO/CA/ - SC 13G/A Passive Investment

UNITED STATES OMB APPROVAL SECURITIES AND EXCHANGE COMMISSION OMB Number: 3235-0145 Washington, D.

August 5, 2020 10-Q

Quarterly Report - 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-36182 Xencor, Inc.

August 5, 2020 EX-10.1

Third Amendment to Lease, dated April 30, 2020, by and between the Company and 111 Lemon Investors LLC (incorporated by reference to Exhibit 10.1 to the Company’s Form 10-Q filed with the SEC on August 5, 2020).

Exhibit 10.1 THIRD AMENDMENT TO LEASE This THIRD AMENDMENT TO LEASE (this “Amendment”) is made and effective as of April 30, 2020 (the “Effective Date”) by and between 111 LEMON INVESTORS LLC, a California limited liability company successor-in-interest to BF Monrovia, LLC, a California limited liability company (“Landlord”) and XENCOR, INC., a Delaware corporation successor-in-interest to Xencor,

August 4, 2020 EX-99.1

Xencor Reports Second Quarter 2020 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Second Quarter 2020 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - MONROVIA, Calif.-August 4, 2020- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer and autoimmune diseases, today reported financial results for the second quarter ended June 30, 2

August 4, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State of incorporation) (Commission File No.) (IRS Employer Identific

July 10, 2020 SC 13G/A

XNCR / Xencor, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 2)* Name of issuer: Xencor Inc. Title of Class of Securities: Common Stock CUSIP Number: 98401F105 Date of Event Which Requires Filing of this Statement: June 30, 2020 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rule 13d-1(

June 26, 2020 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State of incorporation) (Commission File No.) (IRS Employer Identifica

June 17, 2020 SC 13G

XNCR / Xencor, Inc. / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ) Xencor, Inc. (Name of Issuer) Common Stock, par value $0.01 (Title of Class of Securities) 98401F105 (CUSIP Number) June 8, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

June 10, 2020 SC 13D/A

XNCR / Xencor, Inc. / STAFFORD JOHN S III - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D/A (Amendment No.

June 5, 2020 SC 13G/A

XNCR / Xencor, Inc. / PRIMECAP MANAGEMENT CO/CA/ - SC 13G/A Passive Investment

UNITED STATES OMB APPROVAL SECURITIES AND EXCHANGE COMMISSION OMB Number: 3235-0145 Washington, D.

June 3, 2020 SC 13D/A

XNCR / Xencor, Inc. / STAFFORD JOHN S III - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D/A (Amendment No.

May 20, 2020 SC 13D/A

XNCR / Xencor, Inc. / STAFFORD JOHN S III - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D/A (Amendment No.

May 12, 2020 SC 13D/A

XNCR / Xencor, Inc. / STAFFORD JOHN S III - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D/A (Amendment No.

May 8, 2020 10-Q

Quarterly Report - 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-36182 Xencor, Inc.

May 7, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State of incorporation) (Commission File No.) (IRS Employer Identificati

May 7, 2020 EX-99.1

Xencor Reports First Quarter 2020 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports First Quarter 2020 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - MONROVIA, Calif., May 7, 2020 - Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer and autoimmune diseases, today reported financial results for the first quarter ended March 31, 202

May 1, 2020 SC 13D/A

XNCR / Xencor, Inc. / STAFFORD JOHN S III - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D/A (Amendment No.

April 29, 2020 DEFA14A

- DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 29, 2020 DEF 14A

- DEF 14A

Table of Contents SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 8, 2020 SC 13D/A

XNCR / Xencor, Inc. / STAFFORD JOHN S III - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D/A (Amendment No.

February 25, 2020 EX-4.3

Description of the Common Stock of the Company (incorporated by reference to Exhibit 4.3 to the Company’s Form 10-K filed with the SEC on February 25, 2020).

Exhibit 4.3 DESCRIPTION OF COMMON STOCK The following summary description of the common stock of Xencor, Inc. (we, our or us) is based on the provisions of our amended and restated certificate of incorporation, as well as our amended and restated bylaws, and the applicable provisions of the Delaware General Corporation Law. This information is qualified entirely by reference to the applicable prov

February 25, 2020 EX-10.34

Employment Agreement dated November 13, 2019 by and between the Company and Dr. Allen Yang, M.D., Ph.D. (incorporated by reference to Exhibit 10.34 to the Company’s Form 10-K filed with the SEC on February 25, 2020).

Exhibit 10.34 November 12, 2019 Dr. Allan S. Yang Dear Dr. Yang, Congratulations! I am pleased to confirm our offer of a position as Senior Vice President and Chief Medical Officer reporting to the President & CEO. The specifics of this offer, subject to approval by the Board of Directors, are as follows: · Annual base salary of Four Hundred Sixty Five Thousand dollars ($465,000), less standard wi

February 25, 2020 S-8

February 25, 2020 (File No. 333-236607)

As filed with the Securities and Exchange Commission on February 24, 2020 Registration No.

February 25, 2020 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36182 Xencor, Inc.

February 25, 2020 EX-10.33

Employment Agreement dated August 5, 2019 by and between the Company and Celia Eckert (incorporated by reference to Exhibit 10.33 to the Company’s Form 10-K filed with the SEC on February 25, 2020).

Exhibit 10.33 revised August 5, 2019 Ms. Celia Eckert Dear Ms. Eckert, Congratulations! I am pleased to confirm our offer of a position as Vice President, General Counsel and Corporate Secretary reporting to the President & CEO. The specifics of this offer, subject to approval by the Board of Directors, are as follows: · Start date of September 3rd, 2019 · Annual base salary of Three Hundred Seven

February 24, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2020 XENCOR, INC. (Exact name of registrant as specified in its charter) Delaware 001-36182 20-1622502 (State of incorporation) (Commission File No.) (IRS Employer Identi

February 24, 2020 EX-99.1

Xencor Reports Fourth Quarter and Full Year 2019 Financial Results -- Management to Host Conference Call at 4:30 p.m. ET Today --

Exhibit 99.1 Xencor Reports Fourth Quarter and Full Year 2019 Financial Results - Management to Host Conference Call at 4:30 p.m. ET Today - MONROVIA, Calif., Feb. 24, 2020 - Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer and autoimmune diseases, today reported financial results for the fourth quarter a

February 14, 2020 SC 13G

45782T105 / Inmune Bio Inc. / Xencor Inc - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2020 SC 13G/A

XNCR / Xencor, Inc. / Redmile Group, LLC - SCHEDULE 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1) Xencor, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 98401F105 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whi

February 12, 2020 SC 13G/A

XNCR / Xencor, Inc. / PRIMECAP MANAGEMENT CO/CA/ - SC 13G/A Passive Investment

UNITED STATES OMB APPROVAL SECURITIES AND EXCHANGE COMMISSION OMB Number: 3235-0145 Washington, D.

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