XENE Insider Trading - Xenon Pharmaceuticals Inc.

Jumlah Saham Beredar	77,105,799 shares
Saham Orang Dalam	1,060,395 shares
Kepemilikan oleh Orang Dalam	1.38 %
Orang Dalam Sejati	38

Skor Sentimen Orang Dalam

Skor Sentimen Orang Dalam mengidentifikasi perusahaan yang dibeli oleh orang dalam korporat.

Ini adalah hasil dari model kuantitatif multifaktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi internal tertinggi. Model penilaian ini menggunakan kombinasi dari jumlah bersih orang dalam yang membeli dalam 90 hari sebelumnya, total saham yang dibeli sebagai persentase dari jumlah saham yang beredar, dan total saham yang dimiliki oleh orang dalam. Angka tersebut berkisar dari 0 hingga 100, dengan angka yang lebih tinggi menunjukkan tingkat akumulasi yang lebih tinggi dibandingkan dengan perusahaan sejenis, dan 50 adalah rata-rata.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan akumulasi orang dalam tertinggi.

Lihat Saham dengan Peringkat Tertinggi

Skor Sentimen Petugas

Skor Sentimen Pejabat menemukan perusahaan yang dibeli oleh Pejabat Korporat.

Menurut definisi, Pejabat Korporasi adalah Orang Dalam Korporasi, tetapi tidak seperti beberapa Orang Dalam lainnya (Pemegang Saham 10% dan Anggota Dewan), Pejabat bekerja untuk perusahaan setiap hari, dan mereka menggunakan uang mereka sendiri saat bertransaksi . (Pemegang Saham 10% dan Anggota Dewan seringkali adalah manajer dana yang mengelola uang orang lain.) Dengan demikian, transaksi orang dalam yang dilakukan oleh Pejabat jauh lebih signifikan dan harus ditangani dengan tepat.

Seperti Skor Sentimen Internal, Skor Sentimen Pejabat adalah hasil dari model kuantitatif multi-faktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi pejabat tertinggi.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan sentimen orang dalam tertinggi.

Lihat Saham dengan Peringkat Tertinggi

Metrik Utama Orang Dalam

Kartu ini menunjukkan peringkat perusahaan berdasarkan berbagai metrik internal. Peringkat persentil menunjukkan bagaimana perusahaan ini dibandingkan dengan perusahaan lain di pasar AS. Peringkat yang lebih tinggi menunjukkan situasi yang lebih baik.

Sebagai contoh, secara umum diterima bahwa pembelian oleh orang dalam perusahaan adalah indikator positif, sehingga perusahaan dengan lebih banyak pembelian oleh orang dalam akan mendapat peringkat lebih tinggi daripada perusahaan dengan lebih sedikit pembelian oleh orang dalam (atau bahkan penjualan oleh orang dalam).

Jumlah Bersih Pembelian oleh Orang Dalam (Peringkat)

-1 ( )

9883 out of 11305

Jumlah Bersih Pembelian oleh Orang Dalam adalah total jumlah orang dalam yang membeli dikurangi total jumlah orang dalam yang menjual dalam 90 hari terakhir. Peringkat persentil ditunjukkan di sini (kisaran dari 0 hingga 100%).

Persentase Saham yang Dibeli oleh Orang Dalam (Peringkat)

0.000 %( )

5172 out of 11224

Persentase Saham yang Dibeli oleh Orang Dalam adalah total jumlah saham yang dibeli oleh orang dalam dikurangi total jumlah saham yang dijual oleh orang dalam dalam 90 hari terakhir, dibagi dengan total jumlah saham yang beredar dan dikalikan dengan 100.

Grafik Perdagangan Orang Dalam

Grafik berikut menunjukkan Xenon Pharmaceuticals Inc. transaksi orang dalam. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Secara umum, melakukan transaksi di perusahaan mereka berdasarkan informasi material yang belum dipublikasikan adalah ilegal bagi orang dalam. Ini tidak berarti bahwa mereka dilarang melakukan transaksi apa pun di perusahaan mereka sendiri. Namun, mereka wajib melaporkan semua transaksi kepada SEC melalui Formulir 4.

Daftar Orang Dalam dan Metrik Profitabilitas

Tabel ini menampilkan daftar orang dalam yang diketahui, dan dibuat secara otomatis dari pengajuan yang diungkapkan kepada SEC. Selain nama, jabatan terbaru, dan sebutan direktur, pejabat, atau pemilik 10%, kami memberikan kepemilikan terbaru yang diungkapkan. Selain itu, jika memungkinkan, kami memberikan kinerja perdagangan historis untuk orang dalam tersebut. Kinerja perdagangan historis adalah rata-rata tertimbang dari kinerja transaksi pembelian pasar terbuka aktual yang dilakukan oleh orang dalam tersebut. Untuk informasi lebih lanjut tentang bagaimana ini dihitung, tonton webinar YouTube ini.

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Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Sherry Aulin Chief Financial Officer - [O]	0	0
Ernesto Aycardi-fonseca Chief Medical Officer - [O]	0	0
Mohammad Azab Director - [D]	74,225	74,225
Biotechnology Value Fund Ii Lp -	59,464	59,464
Biotechnology Value Fund L P -	59,464	59,464
Bvf Inc/il 10% Owner - [10%]	59,464	59,464
Bvf Partners L P/il 10% Owner - [10%]	59,464	59,464
BVF Partners OS Ltd. -	59,464	59,464
Biotechnology Value Trading Fund OS LP -	59,464	59,464
Gary Bridger	5,144
Cohen Charles J. VP, Biology - [O]	6,550	6,550
Corraini Karen G. See Remarks - [O]	4,114	4,114

Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Gillian Cannon Director - [D]	0	0
Darren S Cline Chief Commercial Officer - [O]	0	0
Clarissa Desjardins Director - [D]	0	0
Andrea DiFabio Chief Legal Officer - [O]	0	0
Empfield James R. EVP, Drug Discovery - [O]	10,000	10,000
Johnston L Evans Director - [D]	444,655	444,655
Steven Gannon Director - [D]	7,141	7,141
Garofalo Elizabeth A. Director - [D]	0	0
Goldberg Y. Paul VP of Clinical Development - [O]	6,000	6,000
Gover Justin D. Director - [D]	0	0
Frank A Holler Director - [D]	143,653	143,653
Michael R Hayden Director - [D]	116,206	116,206
Christopher John Kenney Chief Medical Officer - [O]	0	0

Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Mark N Lampert 10% Owner - [10%]	59,464	59,464
Ian Mortimer PRESIDENT & CEO, Director - [D] [O]	31,302	31,302
Associates, LLP MX 10% Owner - [10%]	0	0
Patrick Machado Director - [D]	0	0
Gary Patou Director - [D]	23,573	23,573
Pimstone Simon N. Director - [D]	6,000	6,000
Sherrington Robin EVP, Strategy & Innovation - [O]	8,398	8,398
Richard H Scheller Director - [D]	7,000	7,000
Stein Evan A. Director - [D]	4,172	4,172
Dawn Svoronos Director - [D]	25,000	25,000
Michael M Tarnow Director - [D]	77,942	77,942
Seggern Christopher Von Chief Commercial Officer - [O]	4,000	4,000
Raymond Winquist Head, Translational Research - [O]	1,000	1,000

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Rekam Jejak Pembelian Orang Dalam - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di XENE / Xenon Pharmaceuticals Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Maksimal	Harga di Maksimal	Maksimal Keuntungan ($)	Maksimum Pengembalian (%)
2022-01-21	KENNEY CHRISTOPHER JOHN	700	28.8100	700	28.8100	20,167	215	39.8200	7,707	38.22
2021-12-06	Von Seggern Christopher	4,000	24.4000	4,000	24.4000	97,600
2017-11-15	AZAB MOHAMMAD	15,000	2.2187	15,000	2.2187	33,280
2017-09-22	AZAB MOHAMMAD	8,000	2.9500	8,000	2.9500	23,600
2017-09-21	AZAB MOHAMMAD	2,000	2.9500	2,000	2.9500	5,900
2017-08-18	AZAB MOHAMMAD	6,312	2.8995	6,312	2.8995	18,302
2017-08-18	WINQUIST RAYMOND	1,000	2.9950	1,000	2.9950	2,995
2017-08-17	AZAB MOHAMMAD	23	2.6500	23	2.6500	61
2017-08-15	EMPFIELD JAMES R.	10,000	2.4824	10,000	2.4824	24,824

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

XENE / Xenon Pharmaceuticals Inc. Insider Trades

Rekam Jejak Penjualan Orang Dalam - Analisis Kerugian Jangka Pendek

Dalam bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan dalam pasar terbuka yang tidak direncanakan oleh orang dalam yang dilakukan di XENE / Xenon Pharmaceuticals Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Menit	Harga di Menit	Kerugian Maksimal Dihindari ($)	Kerugian Maksimal Dihindari (%)
2025-06-05	GANNON STEVEN	3	30.4800	3	30.4800	91	50	30.3000	-0	-0.11
2024-12-18	AULIN SHERRY	7,199	41.2300	7,199	41.2300	296,815
2024-12-18	AULIN SHERRY	11,510	41.1900	11,510	41.1900	474,097
2024-11-22	PATOU GARY	2,851	41.1100	2,851	41.1100	117,205
2024-11-22	PATOU GARY	2,040	41.0500	2,040	41.0500	83,742
2024-03-08	GAROFALO ELIZABETH A.	2,092	45.6900	2,092	45.6900	95,583
2024-03-07	ROBIN SHERRINGTON	1,019	46.1500	1,019	46.1500	47,027
2024-03-07	ROBIN SHERRINGTON	6,118	46.3000	6,118	46.3000	283,263
2024-03-07	GANNON STEVEN	1,000	46.4500	1,000	46.4500	46,450

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

Riwayat Transaksi

Klik ikon tautan untuk melihat riwayat transaksi lengkap. Transaksi yang dilaporkan sebagai bagian dari rencana perdagangan otomatis 10b5-1 akan memiliki tanda X di kolom yang bertanda 10b-5.

Berkas Tanggal	Perdagangan Tanggal	Formulir	Orang Dalam	Ticker	Judul Keamanan	Kode	Langsung	Latihan Harga	Satuan Harga	Unit Diubah	Nilai Diubah (1 ribu)	Sisa Pilihan	Sisa Saham
2025-06-24		3	Cline Darren S	XENE	No securities are beneficially owned.		D						0
2025-06-06	2025-06-05	4	GANNON STEVEN	XENE	Common Shares	S - Sale	D		30.4800	-3	-0		7,141
2025-05-16	2025-05-14	4	GANNON STEVEN	XENE	Common Shares	M - Exercise	D		12.5700	5,144	65		7,144
2025-01-27	2025-01-27	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		41.0700	-1,149	-47		31,302
2025-01-27	2025-01-27	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		17.7600	1,149	20		32,451
2025-01-27	2025-01-27	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		40.4600	-15,166	-614		31,302
2025-01-27	2025-01-27	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		17.7600	15,166	269		46,468
2025-01-27	2025-01-24	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		40.2000	-22,468	-903		31,302
2025-01-27	2025-01-24	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		17.7600	22,468	399		53,770
2025-01-27	2025-01-23	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		40.0800	-16,217	-650		31,302
2025-01-27	2025-01-23	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		17.7600	16,217	288		47,519
2024-12-19	2024-12-18	4	AULIN SHERRY	XENE	Common Shares	S - Sale	D		41.1900	-11,510	-474		0
2024-12-19	2024-12-18	4	AULIN SHERRY	XENE	Common Shares	F - Taxes	D		41.2800	-4,490	-185		11,510
2024-12-19	2024-12-18	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		11.5800	16,000	185		16,000
2024-12-19	2024-12-18	4	AULIN SHERRY	XENE	Common Shares	S - Sale	D		41.2300	-7,199	-297		0
2024-12-19	2024-12-18	4	AULIN SHERRY	XENE	Common Shares	F - Taxes	D		41.2800	-2,135	-88		7,199
2024-12-19	2024-12-18	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		9.4400	9,334	88		9,334
2024-11-22	2024-11-22	4	PATOU GARY	XENE	Common Shares	S - Sale	D		41.0500	-2,040	-84		23,573
2024-11-22	2024-11-22	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		39.8000	-1,046	-42		25,613
2024-11-22	2024-11-22	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		13.4800	3,086	42		26,659
2024-11-22	2024-11-22	4	PATOU GARY	XENE	Common Shares	S - Sale	D		41.1100	-2,851	-117		23,573
2024-11-22	2024-11-22	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		39.8000	-649	-26		26,424
2024-11-22	2024-11-22	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		7.3800	3,500	26		27,073
2024-03-11	2024-03-08	4	GAROFALO ELIZABETH A.	XENE	Common Shares	S - Sale	D		45.6900	-2,092	-96		0
2024-03-11	2024-03-08	4	GAROFALO ELIZABETH A.	XENE	Common Shares	F - Taxes	D		46.1600	-1,408	-65		2,092
2024-03-11	2024-03-08	4	GAROFALO ELIZABETH A.	XENE	Common Shares	M - Exercise	D		18.5600	3,500	65		3,500
2024-03-08	2024-03-07	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		46.3000	-6,118	-283		8,398
2024-03-08	2024-03-07	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		46.1500	-1,019	-47		14,516
2024-03-08	2024-03-07	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		45.9600	-1,289	-59		15,535
2024-03-08	2024-03-07	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		9.8500	7,407	73		16,824
2024-03-08	2024-03-07	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		45.9600	-215	-10		9,417
2024-03-08	2024-03-07	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		9.8500	1,234	12		9,632
2024-03-08	2024-03-07	4	GANNON STEVEN	XENE	Common Shares	S - Sale	D		46.2012	-2,000	-92		2,000
2024-03-08	2024-03-07	4	GANNON STEVEN	XENE	Common Shares	S - Sale	D		46.3025	-5,000	-232		4,000
2024-03-08	2024-03-07	4	GANNON STEVEN	XENE	Common Shares	S - Sale	D		46.2500	-5,000	-231		9,000
2024-03-08	2024-03-07	4	GANNON STEVEN	XENE	Common Shares	S - Sale	D		46.4500	-1,000	-46		14,000
2024-01-02	2023-12-29	4	ROBIN SHERRINGTON	XENE	Common Shares	J - Other	D			-8,398			8,398
2023-12-20	2023-12-19	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		9.8500	3,497	34		74,225
2023-12-20	2023-12-19	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		9.8500	823	8		70,728
2023-12-15	2023-12-14	4/A	PATOU GARY See Note	XENE	Common Shares	S - Sale	I		41.0500	-7,598	-312		4,902
2023-12-15	2023-12-13	4	PATOU GARY See Note	XENE	Common Shares	S - Sale	I		41.0500	-7,598	-312		4,902
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	S - Sale	D		39.8400	-3,977	-158		23,573
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		39.6800	-1,167	-46		27,550
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		9.0000	5,144	46		28,717
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	S - Sale	D		39.1000	-2,303	-90		23,573
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		39.6800	-577	-23		25,876
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		9.8500	2,880	28		26,453
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	S - Sale	D		38.9400	-5,100	-199		23,573
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		39.6800	-1,278	-51		28,673
2023-12-15	2023-12-13	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		9.8500	6,378	63		29,951
2023-08-24	2023-08-24	4	Svoronos Dawn	XENE	Common Shares	S - Sale	D		38.7000	-25,000	-968		25,000
2023-08-10		3	Gover Justin D.	XENE	No securities are beneficially owned.		D						0
2023-08-10		3	Cannon Gillian	XENE	No securities are beneficially owned.		D						0
2023-06-01	2023-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.7800	-24,255	-941		6,000
2023-06-01	2023-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		38.5300	-20,745	-799		30,255
2023-06-01	2023-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		17.7600	45,000	799		51,000
2023-06-01	2023-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.9700	-7,458	-291		6,000
2023-06-01	2023-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		38.5300	-1,860	-72		13,458
2023-06-01	2023-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		7.6900	9,318	72		15,318
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.6900	-26,856	-1,039		6,000
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		38.3700	-23,144	-888		32,856
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		17.7600	50,000	888		56,000
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.8100	-23,670	-919		6,000
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		38.3700	-6,165	-237		29,670
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		9.8500	29,835	294		35,835
2023-06-01	2023-05-31	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.5300	-12,000	-462		6,000
2023-06-01	2023-05-30	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		39.9000	-19,000	-758		18,000
2023-06-01	2023-05-30	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.6300	-18,006	-696		37,000
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		41.4900	-1,407	-58		31,302
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	F - Taxes	D		41.8400	-1,171	-49		32,709
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		9.8500	6,172	61		33,880
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		41.3700	-13,179	-545		27,708
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	F - Taxes	D		41.8400	-3,902	-163		40,887
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		9.8500	20,576	203		44,789
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	S - Sale	D		41.4400	-17,069	-707		24,213
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	F - Taxes	D		41.8400	-7,310	-306		41,282
2023-05-26	2023-05-24	4	MORTIMER IAN	XENE	Common Shares	M - Exercise	D		9.4400	42,592	402		48,592
2023-03-24	2023-03-24	4	KENNEY CHRISTOPHER JOHN	XENE	Common Shares	S - Sale	D		35.0100	-700	-25		0
2023-03-09	2023-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		36.9400	-8,242	-304		55,006
2023-03-09	2023-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		37.1300	-1,618	-60		63,248
2023-03-09	2023-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		2.5900	30,864	80		64,866
2023-03-09	2023-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		37.0100	-10,990	-407		34,002
2023-03-09	2023-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		37.1300	-2,160	-80		44,992
2023-03-09	2023-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		2.6800	41,152	110		47,152
2022-12-13	2022-12-12	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		2.6800	3,086	8		69,905
2022-11-28	2022-11-25	4	PATOU GARY	XENE	Common Shares	S - Sale	D		34.7911	-1,937	-67		23,573
2022-11-28	2022-11-25	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		34.3700	-120	-4		25,510
2022-11-28	2022-11-25	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		2.6800	2,057	6		25,630
2022-11-28	2022-11-23	4	PATOU GARY	XENE	Common Shares	S - Sale	D		34.3265	-2,057	-71		23,573
2022-11-09		3	DiFabio Andrea	XENE	No securities are beneficially owned.		D						0
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	S - Sale	D		39.5700	-15,355	-608		0
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	F - Taxes	D		39.5300	-3,293	-130		15,355
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		4.7500	6,511	31		18,648
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		3.1000	2,292	7		12,137
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		8.4000	813	7		9,845
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		7.4900	32	0		9,032
2022-09-07	2022-09-02	4	AULIN SHERRY	XENE	Common Shares	M - Exercise	D		9.4400	9,000	85		9,000
2022-09-02	2022-09-01	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		38.8000	-8,776	-341		16,796
2022-09-02	2022-09-01	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		38.0300	-35,103	-1,335		25,572
2022-09-02	2022-09-01	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		38.8100	-6,121	-238		60,675
2022-09-02	2022-09-01	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		4.7500	50,000	238		66,796
2022-09-02	2022-08-31	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		38.5700	-21,352	-824		16,796
2022-09-02	2022-08-31	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		37.8600	-1,572	-60		38,148
2022-09-02	2022-08-31	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		4.7500	5,000	24		39,720
2022-09-02	2022-08-31	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		2.6700	17,488	47		34,720
2022-08-16	2022-08-12	4	EMPFIELD JAMES R.	XENE	Common Shares	S - Sale	D		38.6800	-21,875	-846		10,000
2022-08-16	2022-08-12	4	EMPFIELD JAMES R.	XENE	Common Shares	S - Sale	D		38.0800	-35,868	-1,366		31,875
2022-08-16	2022-08-12	4	EMPFIELD JAMES R.	XENE	Common Shares	F - Taxes	D		38.0200	-7,257	-276		67,743
2022-08-16	2022-08-12	4	EMPFIELD JAMES R.	XENE	Common Shares	M - Exercise	D		4.7500	45,000	214		75,000
2022-08-16	2022-08-12	4	EMPFIELD JAMES R.	XENE	Common Shares	M - Exercise	D		3.1000	20,000	62		30,000
2022-08-16	2022-08-16	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.8700	-20,000	-777		6,000
2022-08-16	2022-08-16	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.2900	-32,058	-1,228		26,000
2022-08-16	2022-08-15	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		37.7600	-33,942	-1,282		58,058
2022-08-16	2022-08-12	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		39.1500	-1,000	-39		92,000
2022-08-16	2022-08-12	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		38.6000	-47,000	-1,814		93,000
2022-08-16	2022-08-12	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		37.9100	-43,135	-1,635		140,000
2022-03-14	2022-03-10	4	Von Seggern Christopher	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		100,000		100,000
2022-03-14	2022-03-10	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		75,000		75,000
2022-03-14	2022-03-10	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		25,000		25,000
2022-03-14	2022-03-10	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		400,000		400,000
2022-03-14	2022-03-10	4	KENNEY CHRISTOPHER JOHN	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		125,000		125,000
2022-03-14	2022-03-10	4	AULIN SHERRY	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		125,000		125,000
2022-03-14	2022-03-10	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	30.01		65,000		65,000
2022-03-08	2022-03-08	4/A	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.8000	-2,500	-77		193,135
2022-03-08	2022-03-08	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.5000	-2,500	-76		183,135
2022-03-08	2022-03-08	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.5500	-2,500	-76		185,635
2022-03-08	2022-03-08	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.2000	-2,500	-76		188,135
2022-03-08	2022-03-08	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.1000	-2,500	-75		190,635
2022-03-08	2022-03-08	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		3.8000	-2,500	-10		193,135
2022-03-08	2022-03-08	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.6000	-2,051	-63		195,635
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-20,576		0
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.5500	-2,500	-76		197,686
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.5000	-7,500	-229		200,186
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.5200	-2,500	-76		207,686
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.4400	-4,516	-137		210,186
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.4500	-4,516	-138		214,702
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.4900	-4,517	-138		219,218
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.6000	-5,037	-154		223,735
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		30.2300	-1,990	-60		228,772
2022-03-08	2022-03-07	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.6700	20,576	76		230,762
2022-03-08	2022-03-04	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-10,288		0
2022-03-08	2022-03-04	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.5600	-4,793	-146		210,186
2022-03-08	2022-03-04	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		30.6600	-4,532	-139		214,979
2022-03-08	2022-03-04	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		31.4200	-963	-30		219,511
2022-03-08	2022-03-04	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.6700	10,288	38		220,474
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-6,172		0
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-1,234		0
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		30.2300	-5,000	-151		17,232
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		31.0500	-5,000	-155		22,232
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		30.1500	-5,000	-151		27,232
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		30.5600	-6,710	-205		32,232
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.6700	6,172	23		38,942
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		31.4200	-696	-22		32,770
2022-03-08	2022-03-04	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.6700	1,234	5		33,466
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	M - Exercise	D	6.76		-40,000		0
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	M - Exercise	D	8.40		-2,500		0
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Common Shares	S - Sale	D		30.5400	-31,048	-948		10,000
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Common Shares	S - Sale	D		30.6200	-1,805	-55		41,048
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Common Shares	F - Taxes	D		30.2300	-8,952	-271		42,853
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Common Shares	M - Exercise	D		6.7600	40,000	270		51,805
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Common Shares	F - Taxes	D		30.2300	-695	-21		11,805
2022-03-08	2022-03-07	4	EMPFIELD JAMES R.	XENE	Common Shares	M - Exercise	D		8.4000	2,500	21		12,500
2022-03-08	2022-03-04	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	M - Exercise	D	8.40		-25,000		0
2022-03-08	2022-03-04	4	EMPFIELD JAMES R.	XENE	Common Shares	S - Sale	D		30.7900	-18,315	-564		10,000
2022-03-08	2022-03-04	4	EMPFIELD JAMES R.	XENE	Common Shares	F - Taxes	D		31.4200	-6,685	-210		28,315
2022-03-08	2022-03-04	4	EMPFIELD JAMES R.	XENE	Common Shares	M - Exercise	D		8.4000	25,000	210		35,000
2022-01-21	2022-01-21	4	KENNEY CHRISTOPHER JOHN	XENE	Common Shares	P - Purchase	D		28.8100	700	20		700
2021-12-17	2021-12-15	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-3,086		0
2021-12-17	2021-12-15	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		3.6700	3,086	11		66,819
2021-12-10	2021-12-08	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-2,057		0
2021-12-10	2021-12-08	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		3.6700	2,057	8		25,630
2021-12-07	2021-12-06	4	Von Seggern Christopher	XENE	Common Shares	P - Purchase	D		24.4000	4,000	98		4,000
2021-11-16	2021-11-15	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		31.3300	-17,557	-550		210,186
2021-08-25		3	KENNEY CHRISTOPHER JOHN	XENE	No securities are beneficially owned.		D						0
2021-08-25	2021-08-23	4	KENNEY CHRISTOPHER JOHN	XENE	Stock Option (Right to Buy)	A - Award	D	16.64		150,000		150,000
2021-06-04	2021-06-03	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		10,000		10,000
2021-06-04	2021-03-17	4	PATOU GARY See Note	XENE	Common Shares	L - Other	I		19.4900	100	2		100
2021-06-03	2021-06-03	4	Svoronos Dawn	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		10,000		10,000
2021-06-03	2021-06-03	4	Machado Patrick	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		10,000		10,000
2021-06-03	2021-06-03	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		10,000		10,000
2021-06-03	2021-06-03	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		10,000		10,000
2021-06-03	2021-06-03	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		10,000		10,000
2021-06-03	2021-06-03	4	GAROFALO ELIZABETH A.	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		20,000		20,000
2021-06-03		3	GAROFALO ELIZABETH A.	XENE	No securities are beneficially owned.		D						0
2021-06-03	2021-06-03	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		125,000		125,000
2021-06-03	2021-06-03	4	AULIN SHERRY	XENE	Stock Option (Right to Buy)	A - Award	D	18.56		100,000		100,000
2021-06-03		3	AULIN SHERRY	XENE	No securities are beneficially owned.		D						0
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.85		-13,374		0
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-12,345		0
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		18.8100	-2,912	-55		32,232
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Common Shares	S - Sale	D		18.8100	-3,155	-59		35,144
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		18.9100	-2,192	-41		38,299
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.8500	13,374	51		40,491
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		18.9100	-2,024	-38		27,117
2021-06-01	2021-05-28	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.7600	12,345	46		29,141
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-36,008		0
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-3,086		0
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		18.6800	-8,485	-158		143,653
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		18.6900	-2,579	-48		152,138
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		18.8800	-5,911	-112		154,717
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.7600	36,008	135		160,628
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		18.8800	-507	-10		124,620
2021-06-01	2021-05-27	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.7600	3,086	12		125,127
2021-05-26	2021-05-24	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-22,633		0
2021-05-26	2021-05-24	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		19.1700	-5,076	-97		227,743
2021-05-26	2021-05-24	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.7600	22,633	85		232,819
2021-05-20	2021-05-18	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-5,144		0
2021-05-20	2021-05-18	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-1,028		0
2021-05-20	2021-05-18	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.87		-2,057		0
2021-05-20	2021-05-18	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.6700	5,144	19		77,942
2021-05-20	2021-05-18	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.6700	1,028	4		72,798
2021-05-20	2021-05-18	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.8700	2,057	8		71,770
2021-05-20	2021-05-18	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.85		-3,500		0
2021-05-20	2021-05-18	4	Hayden Michael R	XENE	Common Shares	M - Exercise	D		3.8500	3,500	13		116,206
2021-03-15	2021-03-12	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	20.55		65,000		65,000
2021-03-15	2021-03-12	4	Von Seggern Christopher	XENE	Stock Option (Right to Buy)	A - Award	D	20.55		60,000		60,000
2021-03-15	2021-03-12	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	20.55		65,000		65,000
2021-03-15	2021-03-12	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	20.55		100,000		100,000
2021-03-15	2021-03-12	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	20.55		225,000		225,000
2021-02-18	2021-02-18	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	2.68		-30,864		0
2021-02-18	2021-02-18	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	3.67		-10,288		0
2021-02-18	2021-02-18	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		2.6800	30,864	83		92,076
2021-02-18	2021-02-18	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		3.6700	10,288	38		61,212
2021-02-18	2021-02-16	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	M - Exercise	D	2.68		-5,144		0
2021-02-18	2021-02-16	4	Hayden Michael R	XENE	Common Shares	M - Exercise	D		2.6800	5,144	14		112,706
2020-12-15	2020-12-15	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-3,086		0
2020-12-15	2020-12-15	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		3.7600	3,086	12		63,733
2020-11-05	2020-11-05	4	Machado Patrick	XENE	Stock Option (Right to Buy)	A - Award	D	11.85		20,000		20,000
2020-11-05		3	Machado Patrick	XENE	No securities are beneficially owned		D						0
2020-10-29	2020-10-28	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-5,144		0
2020-10-29	2020-10-28	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-5,144		0
2020-10-29	2020-10-28	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-10,288			69,713
2020-10-29	2020-10-28	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.7600	5,144	19		80,001
2020-10-29	2020-10-28	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.7600	5,144	19		80,001
2020-10-29	2020-10-28	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-2,057		0
2020-10-29	2020-10-28	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		3.7600	2,057	8		23,573
2020-08-24	2020-08-20	4	PIMSTONE SIMON N.	XENE	Common Shares	J - Other	D			-45,000			210,186
2020-08-17	2020-08-17	4	Von Seggern Christopher	XENE	Stock Option (Right to Buy)	A - Award	D	11.27		100,000		100,000
2020-08-17		3	Von Seggern Christopher	XENE	No securities are beneficially owned.		D						0
2020-06-10	2020-06-09	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.52		-5,144		0
2020-06-10	2020-06-09	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.5200	5,144	18		69,713
2020-06-02	2020-06-01	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-06-01	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-8,230		0
2020-06-02	2020-06-01	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		13.7000	-1,630	-22		16,796
2020-06-02	2020-06-01	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.5600	8,230	29		18,426
2020-06-02	2020-06-01	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		14.4300	-3,000	-43		255,186
2020-06-02	2020-05-29	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		13.9900	-5,000	-70		258,186
2020-06-02	2020-06-01	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-05-29	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-3,086		0
2020-06-02	2020-05-29	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.5600	3,086	11		122,041
2020-06-02	2020-06-01	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-06-01	4	Desjardins Clarissa	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-06-01	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-06-01	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-06-01	4	Svoronos Dawn	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-06-02	2020-06-01	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	13.11		10,000		10,000
2020-05-28	2020-05-26	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-6,172		0
2020-05-28	2020-05-26	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		14.9000	-1,108	-17		263,186
2020-05-28	2020-05-26	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.5600	6,172	22		264,294
2020-03-13	2020-03-12	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	11.58		65,000		65,000
2020-03-13	2020-03-12	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	11.58		65,000		65,000
2020-03-13	2020-03-12	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	11.58		145,000		145,000
2020-03-13	2020-03-12	4	AYCARDI-FONSECA ERNESTO	XENE	Stock Option (Right to Buy)	A - Award	D	11.58		65,000		65,000
2020-03-13	2020-03-12	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	11.58		280,000		280,000
2020-01-14	2020-01-13	4	Desjardins Clarissa	XENE	Stock Option (Right to Buy)	A - Award	D	16.42		25,000		25,000
2020-01-14		3	Desjardins Clarissa	XENE	No securities are beneficially owned		D						0
2019-12-17	2019-12-16	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-3,086		0
2019-12-17	2019-12-16	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		3.5600	3,086	11		60,647
2019-12-06	2019-12-04	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-2,057		0
2019-12-06	2019-12-04	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		3.5600	2,057	7		21,516
2019-11-22	2019-11-21	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.51		-2,057		0
2019-11-22	2019-11-21	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-5,144		0
2019-11-22	2019-11-21	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-2,057			64,569
2019-11-22	2019-11-21	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.5100	2,057	7		66,626
2019-11-22	2019-11-21	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-5,144			64,569
2019-11-22	2019-11-21	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.5600	5,144	18		69,713
2019-09-24	2019-09-20	4	PIMSTONE SIMON N.	XENE	Common Shares	S - Sale	D		9.5100	-10,395	-99		258,122
2019-09-20	2019-09-20	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		9.3900	-5,206	-49		118,955
2019-09-20	2019-09-19	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		9.2700	-7,600	-70		124,161
2019-09-18	2019-09-16	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-16	4	SCHELLER RICHARD H	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-16	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		45,000		45,000
2019-09-18	2019-09-16	4	Svoronos Dawn	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.38		-12,345		0
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-9,259		0
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.70		-36,008		0
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		9.4400	-3,692	-35		268,517
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.3800	12,345	42		272,209
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		9.4400	-2,769	-26		259,864
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.0700	9,259	28		262,633
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		9.4400	-10,769	-102		253,374
2019-09-18	2019-09-17	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.7000	36,008	133		264,143
2019-09-18	2019-09-16	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		280,000		280,000
2019-09-18	2019-09-18	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		9.2800	-4,368	-41		131,761
2019-09-18	2019-09-17	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		9.3200	-5,069	-47		136,129
2019-09-18	2019-09-16	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-16	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		135,000		135,000
2019-09-18	2019-09-16	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-16	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		40,000		40,000
2019-09-18	2019-09-16	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-16	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-18	2019-09-16	4	AYCARDI-FONSECA ERNESTO	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		65,000		65,000
2019-09-17	2019-09-16	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	9.44		15,000		15,000
2019-09-17	2019-09-13	4	AZAB MOHAMMAD	XENE	Common Shares	S - Sale	D		9.3122	-23	-0		57,561
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.00		-25,720		0
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-3,086		0
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.70		-3,086		0
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		9.3800	-7,781	-73		141,198
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.0000	25,720	77		148,979
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		9.3800	-934	-9		123,259
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		9.3800	-934	-9		123,259
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.0700	3,086	9		124,193
2019-09-13	2019-09-12	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.7000	3,086	11		122,041
2019-09-13	2019-09-12	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-6,172		0
2019-09-13	2019-09-12	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		9.3800	-1,868	-18		10,196
2019-09-13	2019-09-12	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.0700	6,172	19		12,064
2019-05-23	2019-05-21	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.21		-2,057		0
2019-05-23	2019-05-21	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.2100	2,057	7		64,569
2019-03-20	2019-03-19	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	3.38		-20,576		0
2019-03-20	2019-03-19	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		3.3800	20,576	70		50,924
2019-03-12	2019-03-11	4	Hayden Michael R By Spouse	XENE	Common Shares	G - Gift	I			17,337			114,403
2019-03-12	2019-03-11	4	Hayden Michael R	XENE	Common Shares	G - Gift	D			-24,045			107,562
2018-12-26	2018-12-21	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-5,000			62,512
2018-12-18	2018-12-14	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-2,057		0
2018-12-18	2018-12-14	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		3.0700	2,057	6		19,459
2018-12-13	2018-12-11	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-4,115		0
2018-12-13	2018-12-11	4	COHEN CHARLES J.	XENE	Common Shares	F - Taxes	D		7.0000	-1,644	-12		6,550
2018-12-13	2018-12-11	4	COHEN CHARLES J.	XENE	Common Shares	M - Exercise	D		3.0700	4,115	13		8,194
2018-12-10	2018-12-06	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-3,086		0
2018-12-10	2018-12-06	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		3.0700	3,086	9		57,584
2018-06-22	2018-06-21	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.70		-10,288		0
2018-06-22	2018-06-21	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		3.7000	10,288	38		54,498
2018-06-22	2018-06-21	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-5,144		0
2018-06-22	2018-06-21	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.70		-5,144		0
2018-06-22	2018-06-21	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.66		-2,057		0
2018-06-22	2018-06-21	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.0700	5,144	16		67,512
2018-06-22	2018-06-21	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.6600	2,057	8		62,368
2018-06-22	2018-06-21	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.7000	5,144	19		60,311
2018-06-15	2018-06-14	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.70		-8,230		0
2018-06-15	2018-06-14	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		8.3000	-2,856	-24		17,402
2018-06-15	2018-06-14	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		3.7000	8,230	30		20,258
2018-06-05	2018-06-04	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	SCHELLER RICHARD H	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	Svoronos Dawn	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-06-05	2018-06-04	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	6.20		15,000		15,000
2018-03-29	2018-03-27	4	BVF PARTNERS L P/IL	XENE	Series 1 Preferred Shares	J - Other	D			238,000		238,000
2018-03-29	2018-03-27	4	BVF PARTNERS L P/IL	XENE	Series 1 Preferred Shares	J - Other	D			861,000		861,000
2018-03-29	2018-03-27	4	BVF PARTNERS L P/IL	XENE	Series 1 Preferred Shares	J - Other	D			1,338,000		1,338,000
2018-03-29	2018-03-27	4	BVF PARTNERS L P/IL	XENE	Common Shares, no par value per share	J - Other	D			-238,000			59,464
2018-03-29	2018-03-27	4	BVF PARTNERS L P/IL	XENE	Common Shares, no par value per share	J - Other	D			-861,000			216,694
2018-03-29	2018-03-27	4	BVF PARTNERS L P/IL	XENE	Common Shares, no par value per share	J - Other	D			-1,338,000			336,468
2018-03-20		3	AYCARDI-FONSECA ERNESTO	XENE	No securities are beneficially owned		D						0
2018-03-20	2018-03-19	4	AYCARDI-FONSECA ERNESTO	XENE	Stock Option (Right to Buy)	A - Award	D	4.65		50,000		50,000
2018-03-16	2018-03-14	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.77		-3,086		0
2018-03-16	2018-03-14	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		3.7700	3,086	12		118,955
2018-03-16	2018-03-15	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.77		-3,086		0
2018-03-16	2018-03-15	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		4.6250	-1,928	-9		5,892
2018-03-16	2018-03-15	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.7700	3,086	12		7,820
2018-03-14	2018-03-12	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.77		-10,288		0
2018-03-14	2018-03-12	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.7700	10,288	39		228,135
2018-03-13	2018-03-12	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	4.75		140,000		140,000
2018-03-13	2018-03-12	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	4.75		105,000		105,000
2018-03-13	2018-03-12	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	4.75		55,000		55,000
2018-03-13	2018-03-12	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	4.75		45,000		45,000
2018-03-13	2018-03-12	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	A - Award	D	4.75		40,000		40,000
2018-03-01	2018-02-22	4	Hayden Michael R By Spouse	XENE	Common Shares	G - Gift	I			21,180			97,066
2018-03-01	2018-02-22	4	Hayden Michael R	XENE	Common Shares	G - Gift	D			-29,580			131,607
2018-02-14	2018-02-12	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.71		-26,748		0
2018-02-14	2018-02-12	4	COHEN CHARLES J.	XENE	Common Shares	F - Taxes	D		3.5000	-22,669	-79		4,079
2018-02-14	2018-02-12	4	COHEN CHARLES J.	XENE	Common Shares	M - Exercise	D		3.7100	26,748	99		26,748
2017-11-16	2017-11-15	4	AZAB MOHAMMAD	XENE	Common Shares	P - Purchase	D		2.2187	15,000	33		44,210
2017-10-24	2017-10-23	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	A - Award	D	3.10		11,000		11,000
2017-10-24	2017-10-23	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	3.10		20,000		20,000
2017-10-24	2017-10-23	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	A - Award	D	3.10		11,000		11,000
2017-10-24	2017-10-23	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	3.10		11,000		11,000
2017-10-24	2017-10-23	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	3.10		11,000		11,000
2017-10-24	2017-10-23	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	3.10		25,000		25,000
2017-09-25	2017-09-22	4	AZAB MOHAMMAD	XENE	Common Shares	P - Purchase	D		2.9500	8,000	24		29,210
2017-09-25	2017-09-21	4	AZAB MOHAMMAD	XENE	Common Shares	P - Purchase	D		2.9500	2,000	6		21,210
2017-08-21	2017-08-18	4	WINQUIST RAYMOND	XENE	Common Shares	P - Purchase	D		2.9950	1,000	3		1,000
2017-08-21	2017-08-18	4	AZAB MOHAMMAD	XENE	Common Shares	P - Purchase	D		2.8995	6,312	18		19,210
2017-08-21	2017-08-17	4	AZAB MOHAMMAD	XENE	Common Shares	P - Purchase	D		2.6500	23	0		12,898
2017-08-17	2017-08-15	4	EMPFIELD JAMES R.	XENE	Common Shares	P - Purchase	D		2.4824	10,000	25		10,000
2017-08-16	2017-08-15	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		2.4122	7,429	18		1,077,694
2017-08-16	2017-08-15	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		2.4122	11,429	28		1,674,468
2017-08-16	2017-08-14	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		2.7036	13,337	36		1,070,265
2017-08-16	2017-08-14	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		2.7036	28,007	76		1,663,039
2017-08-15	2017-08-14	4	Svoronos Dawn	XENE	Common Shares	P - Purchase	D		2.8154	50,000	141		50,000
2017-08-14	2017-08-11	4	GANNON STEVEN	XENE	Common Shares	P - Purchase	D		2.8178	15,000	42		15,000
2017-08-14	2017-08-14	4	Hayden Michael R	XENE	Common Shares	P - Purchase	D		2.7498	15,000	41		161,187
2017-08-14	2017-08-10	4	PIMSTONE SIMON N.	XENE	Common Shares	P - Purchase	D		2.9000	6,000	17		217,847
2017-08-14	2017-08-10	4	SCHELLER RICHARD H	XENE	Common Shares	P - Purchase	D		2.8500	7,000	20		7,000
2017-08-14	2017-08-10	4	MORTIMER IAN By Spouse	XENE	Common Stock	P - Purchase	I		2.9000	10,000	29		14,300
2017-08-14	2017-08-10	4	MORTIMER IAN	XENE	Common Stock	P - Purchase	D		2.8450	5,000	14		6,000
2017-08-14	2017-08-10	4	PATOU GARY See Note	XENE	Common Stock	P - Purchase	I		2.7781	7,500	21		12,500
2017-08-10	2017-08-08	4	PATOU GARY See note	XENE	Common Stock	P - Purchase	I		3.0005	5,000	15		5,000
2017-06-30	2017-06-27	4/A	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.0361	8,496	26		297,464
2017-06-30	2017-06-27	4/A	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.0361	30,170	92		1,056,928
2017-06-30	2017-06-27	4/A	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.0361	46,795	142		1,635,032
2017-06-29	2017-06-27	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	8,496	34		297,464
2017-06-29	2017-06-27	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	30,170	121		1,056,928
2017-06-29	2017-06-27	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	46,795	187		1,635,032
2017-06-23	2017-06-22	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	854	3		288,968
2017-06-23	2017-06-22	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	2,884	12		1,026,758
2017-06-23	2017-06-22	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	4,525	18		1,588,237
2017-06-23	2017-06-21	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	1,362	5		288,114
2017-06-23	2017-06-21	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	4,406	18		1,023,874
2017-06-23	2017-06-21	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		4.0000	6,380	26		1,583,712
2017-06-20	2017-06-19	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.51		-1,028		0
2017-06-20	2017-06-19	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-1,028			55,167
2017-06-20	2017-06-19	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.5100	1,028	4		56,195
2017-06-19	2017-06-19	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8500	357	1		286,752
2017-06-19	2017-06-19	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8500	1,271	5		1,019,468
2017-06-19	2017-06-19	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8500	1,967	8		1,577,332
2017-06-19	2017-06-16	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8500	1,064	4		286,395
2017-06-19	2017-06-16	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8500	3,873	15		1,018,197
2017-06-19	2017-06-16	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8500	6,097	23		1,575,365
2017-06-19	2017-06-15	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8370	1,160	4		285,331
2017-06-19	2017-06-15	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8370	3,845	15		1,014,324
2017-06-19	2017-06-15	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8370	6,774	26		1,569,268
2017-06-08	2017-06-07	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8512	20,594	79		284,171
2017-06-08	2017-06-07	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8512	73,749	284		1,010,479
2017-06-08	2017-06-07	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.8512	113,446	437		1,562,494
2017-06-08	2017-06-06	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.7500	913	3		263,577
2017-06-08	2017-06-06	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.7500	53,260	200		936,730
2017-06-08	2017-06-06	4	BVF PARTNERS L P/IL	XENE	Common Stock, no par value per share	P - Purchase	D		3.7500	96,736	363		1,449,048
2017-06-02	2017-06-01	4	SCHELLER RICHARD H	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		1,250		1,250
2017-06-02	2017-06-01	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	Svoronos Dawn	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-06-02	2017-06-01	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	3.85		3,500		3,500
2017-05-16	2017-05-12	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.21		-2,057		0
2017-05-16	2017-05-12	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		4.1800	-1,345	-6		4,734
2017-05-16	2017-05-12	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		3.2100	2,057	7		6,079
2017-03-15	2017-03-14	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	3.56		-3,086		0
2017-03-15	2017-03-14	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	3.07		-4,629		0
2017-03-15	2017-03-14	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	3.77		-4,115		0
2017-03-15	2017-03-14	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.67		-5,144		0
2017-03-15	2017-03-14	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.76		-25,720		0
2017-03-15	2017-03-14	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.70		-18,004		0
2017-03-15	2017-03-14	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		3.5600	3,086	11		30,348
2017-03-15	2017-03-14	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		3.0700	4,629	14		27,262
2017-03-15	2017-03-14	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		3.7700	4,115	16		22,633
2017-03-15	2017-03-14	4	Hayden Michael R	XENE	Common Shares	M - Exercise	D		3.6700	5,144	19		146,187
2017-03-15	2017-03-14	4	Hayden Michael R	XENE	Common Shares	M - Exercise	D		3.7600	25,720	97		141,043
2017-03-15	2017-03-14	4	Hayden Michael R	XENE	Common Shares	M - Exercise	D		3.7000	18,004	67		115,323
2017-03-14	2017-03-13	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		75,000		75,000
2017-03-14	2017-03-13	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		140,000		140,000
2017-03-14	2017-03-13	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		27,500		27,500
2017-03-14	2017-03-13	4	WINQUIST RAYMOND	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		20,000		20,000
2017-03-14	2017-03-13	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		20,000		20,000
2017-03-14	2017-03-13	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		27,500		27,500
2017-03-14	2017-03-13	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	A - Award	D	8.40		27,500		27,500
2017-01-27	2017-01-26	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-7,201			55,167
2016-12-19	2016-12-15	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		7.8500	-30,000	-236		115,869
2016-12-13	2016-12-12	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.21		-14,403		0
2016-12-13	2016-12-12	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-7,202			62,368
2016-12-13	2016-12-12	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.2100	14,403	46		69,570
2016-12-08	2016-12-06	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.21		-12,345		0
2016-12-08	2016-12-06	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		7.9000	-4,403	-35		12,028
2016-12-08	2016-12-06	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		3.2100	12,345	40		16,431
2016-12-02	2016-12-01	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.21		-12,345		0
2016-12-02	2016-12-01	4	AZAB MOHAMMAD	XENE	Common Shares	F - Taxes	D		7.8000	-4,408	-34		12,875
2016-12-02	2016-12-01	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		3.2100	12,345	40		17,283
2016-09-27		3	Svoronos Dawn	XENE	No securities are beneficially owned		D						0
2016-09-27	2016-09-27	4	Svoronos Dawn	XENE	Stock Option (Right to Buy)	A - Award	D	8.15		5,144		5,144
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,381,916
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						3,850,758
2016-09-12		3	LAMPERT MARK N	XENE	Common Stock, no par value per share		D						2,761,110
2016-08-23	2016-08-19	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		7.6510	-11,938	-91		145,869
2016-08-18	2016-08-18	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		7.7000	-9,599	-74		157,807
2016-08-18	2016-08-17	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		7.8900	-1,600	-13		167,406
2016-08-18	2016-08-16	4	HOLLER FRANK A	XENE	Common Shares	S - Sale	D		8.2500	-6,863	-57		169,006
2016-08-02	2016-07-29	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.30		-12,345		0
2016-08-02	2016-07-29	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		7.4600	-4,703	-35		211,847
2016-08-02	2016-07-29	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		3.3000	12,345	41		216,550
2016-06-28	2016-06-24	4	MORTIMER IAN By spouse	XENE	Common Stock	P - Purchase	I		6.3000	1,300	8		4,300
2016-06-28	2016-06-24	4	MORTIMER IAN By spouse	XENE	Common Stock	P - Purchase	I		6.2500	2,000	12		3,000
2016-06-28	2016-06-24	4	MORTIMER IAN By spouse	XENE	Common Stock	P - Purchase	I		6.1000	1,000	6		1,000
2016-06-28	2016-06-24	4	MORTIMER IAN	XENE	Common Stock	P - Purchase	D		6.1500	1,000	6		1,000
2016-06-03	2016-06-02	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-06-03	2016-06-02	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-06-03	2016-06-02	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-06-03	2016-06-02	4	SCHELLER RICHARD H	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-06-03	2016-06-02	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		1,250		1,250
2016-06-03	2016-06-02	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-06-03	2016-06-02	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-06-03	2016-06-02	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	7.38		3,500		3,500
2016-05-27	2016-05-25	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	3.30		-8,230		0
2016-05-27	2016-05-25	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		3.3000	8,230	27		18,518
2016-04-29	2016-04-28	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.35		-1,543		0
2016-04-29	2016-04-28	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-1,543			55,167
2016-04-29	2016-04-28	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		3.3500	1,543	5		56,710
2016-04-04		3	WINQUIST RAYMOND	XENE	No securities are beneficially owned		D						0
2016-04-04	2016-04-04	4	WINQUIST RAYMOND	XENE	Stock Option (Right to Buy)	A - Award	D	7.10		35,000		35,000
2016-03-11	2016-03-11	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	A - Award	D	7.49		20,000		20,000
2016-03-11	2016-03-11	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	7.49		40,000		40,000
2016-03-11	2016-03-11	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	7.49		20,000		20,000
2016-03-11	2016-03-11	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	A - Award	D	7.49		25,000		25,000
2016-03-11	2016-03-11	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	7.49		50,000		50,000
2016-02-09		3	EMPFIELD JAMES R.	XENE	No securities are beneficially owned		D						0
2016-02-09	2016-02-08	4	EMPFIELD JAMES R.	XENE	Stock Option (Right to Buy)	A - Award	D	6.76		40,000		40,000
2015-12-21	2015-12-18	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	7.69		15,000		15,000
2015-12-21	2015-12-16	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	5.22		-411		0
2015-12-21	2015-12-16	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		7.9400	-229	-2		4,022
2015-12-21	2015-12-16	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		5.2200	411	2		4,251
2015-12-21	2015-12-18	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	7.69		40,000		40,000
2015-12-21	2015-12-18	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	7.69		25,000		25,000
2015-12-21	2015-12-18	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	A - Award	D	7.69		15,000		15,000
2015-12-21	2015-12-18	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	A - Award	D	7.69		15,000		15,000
2015-12-14	2015-12-11	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	5.22		2,469		0
2015-12-14	2015-12-11	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		5.2200	2,469	13		4,938
2015-11-25	2015-11-24	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	5.22		-2,057		0
2015-11-25	2015-11-24	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		9.3900	-995	-9		175,869
2015-11-25	2015-11-24	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		5.2200	2,057	11		176,864
2015-11-06	2015-11-04	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	5.22		-3,497		0
2015-11-06	2015-11-04	4	PATOU GARY	XENE	Common Shares	F - Taxes	D		8.3200	-1,955	-16		4,086
2015-11-06	2015-11-04	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		5.2200	3,497	18		6,041
2015-11-04	2015-11-02	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	5.22		-5,041		0
2015-11-04	2015-11-02	4	TARNOW MICHAEL M	XENE	Common Shares	G - Gift	D			-5,041			55,167
2015-11-04	2015-11-02	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		5.2200	5,041	26		60,208
2015-09-24	2015-09-24	4	GOLDBERG Y. PAUL	XENE	Common Shares	S - Sale	D		8.6000	-12,000	-103		6,000
2015-09-24	2015-09-23	4	GOLDBERG Y. PAUL	XENE	Common Shares	S - Sale	D		9.0200	-4,000	-36		18,000
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	2.68		-785		243
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	2.68		-7,973		4,372
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.73		-3,115		1,000
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.52		-3,703		0
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.56		-6,172		0
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.07		-5,144		0
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.77		-1,028		0
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	3.21		-2,057		0
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	5.22		-411		0
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	S - Sale	D		9.3323	-6,149	-57		22,000
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-167	-2		28,149
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		2.6800	785	2		28,316
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-1,687	-16		27,531
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		2.6800	7,973	21		29,218
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-923	-9		21,245
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		3.7300	3,115	12		22,168
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-1,098	-10		19,053
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		3.5200	3,703	13		20,151
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-1,829	-17		16,448
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		3.5600	6,172	22		18,277
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-1,525	-15		12,105
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		3.0700	5,144	16		13,630
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-305	-3		8,486
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		3.7700	1,028	4		8,791
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-610	-6		7,763
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		3.2100	2,057	7		8,373
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		9.5300	-198	-2		6,316
2015-09-24	2015-09-22	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		5.2200	411	2		6,514
2015-08-20	2015-08-18	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-2,057
2015-08-20	2015-08-18	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.81		-1,028
2015-08-20	2015-08-18	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		11.0000	-868	-10		3,840
2015-08-20	2015-08-18	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		4.9800	2,057	10		4,708
2015-08-20	2015-08-18	4	ROBIN SHERRINGTON	XENE	Common Shares	F - Taxes	D		11.0000	-434	-5		2,651
2015-08-20	2015-08-18	4	ROBIN SHERRINGTON	XENE	Common Shares	M - Exercise	D		4.8100	1,028	5		3,085
2015-08-20	2015-08-18	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-15,432		0
2015-08-20	2015-08-18	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.81		-5,144		0
2015-08-20	2015-08-18	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		11.0000	-6,508	-72		204,205
2015-08-20	2015-08-18	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		4.9800	15,432	77		210,713
2015-08-20	2015-08-18	4	PIMSTONE SIMON N.	XENE	Common Shares	F - Taxes	D		11.0000	-2,170	-24		195,281
2015-08-20	2015-08-18	4	PIMSTONE SIMON N.	XENE	Common Shares	M - Exercise	D		4.8100	5,144	25		197,451
2015-08-20	2015-08-18	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-2,057		0
2015-08-20	2015-08-18	4	HOLLER FRANK A	XENE	Common Shares	F - Taxes	D		11.0000	-868	-10		174,807
2015-08-20	2015-08-18	4	HOLLER FRANK A	XENE	Common Shares	M - Exercise	D		4.9800	2,057	10		175,675
2015-08-20	2015-08-18	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-2,057		0
2015-08-20	2015-08-18	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.81		-1,028		0
2015-08-20	2015-08-18	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		11.0000	-868	-10		6,103
2015-08-20	2015-08-18	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		4.9800	2,057	10		6,971
2015-08-20	2015-08-18	4	GOLDBERG Y. PAUL	XENE	Common Shares	F - Taxes	D		11.0000	-434	-5		4,914
2015-08-20	2015-08-18	4	GOLDBERG Y. PAUL	XENE	Common Shares	M - Exercise	D		4.8100	1,028	5		5,348
2015-06-19	2015-06-17	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.95		-1,543		0
2015-06-19	2015-06-17	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		4.9500	1,543	8		55,167
2015-05-22		3	GANNON STEVEN	XENE	No securities are beneficially owned		D						0
2015-05-22	2015-05-21	4	GANNON STEVEN	XENE	Stock Option (Right to Buy)	A - Award	D	12.57		5,144		5,144
2015-05-06	2015-05-04	4	SCHELLER RICHARD H	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-06	2015-05-04	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-06	2015-05-04	4	Evans Johnston L	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-06	2015-05-04	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-06	2015-05-04	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-06	2015-05-04	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		1,028		1,028
2015-05-06	2015-05-04	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-06	2015-05-04	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	13.48		3,086		3,086
2015-05-04	2015-04-30	4	STEIN EVAN A.	XENE	Common Shares	J - Other	I			4,172			4,172
2015-05-04	2015-04-30	4	STEIN EVAN A.	XENE	Common Shares	J - Other	I			909,619			910,586
2015-05-04	2015-04-30	4	STEIN EVAN A.	XENE	Common Shares	J - Other	I			-1,038,964			0
2015-03-19	2015-03-17	4	ROBIN SHERRINGTON	XENE	Stock Option (Right to Buy)	A - Award	D	17.76		35,000		35,000
2015-03-19	2015-03-17	4	PIMSTONE SIMON N.	XENE	Stock Option (Right to Buy)	A - Award	D	17.76		95,000		95,000
2015-03-19	2015-03-17	4	MORTIMER IAN	XENE	Stock Option (Right to Buy)	A - Award	D	17.76		55,000		55,000
2015-03-19	2015-03-17	4	GOLDBERG Y. PAUL	XENE	Stock Option (Right to Buy)	A - Award	D	17.76		35,000		35,000
2015-03-19	2015-03-17	4	CORRAINI KAREN G.	XENE	Stock Option (Right to Buy)	A - Award	D	17.76		35,000		35,000
2015-03-19	2015-03-17	4	COHEN CHARLES J.	XENE	Stock Option (Right to Buy)	A - Award	D	17.76		35,000		35,000
2015-03-18		3	SCHELLER RICHARD H	XENE	No securities are beneficially owned		D						0
2015-03-18	2015-03-16	4	SCHELLER RICHARD H	XENE	Stock Option (Right to Buy)	A - Award	D	17.65		5,144		5,144
2015-02-05	2015-02-03	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	4.81		-5,144		0
2015-02-05	2015-02-03	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		4.8100	5,144	25		10,288
2015-01-21	2015-01-07	4/A	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-3,497		0
2015-01-21	2015-01-07	4/A	PATOU GARY	XENE	Common Shares	F - Taxes	D		22.2800	-953	-21		2,544
2015-01-21	2015-01-07	4/A	PATOU GARY	XENE	Common Shares	M - Exercise	D		4.9800	3,497	17		3,497
2015-01-12	2015-01-08	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-2,469		0
2015-01-12	2015-01-08	4	AZAB MOHAMMAD	XENE	Common Shares	M - Exercise	D		4.9800	2,469	12		2,469
2015-01-12	2015-01-08	4	Hayden Michael R By Genworks Inc.	XENE	Stock Option (Right to Buy)	M - Exercise	I	4.98		-5,144		0
2015-01-12	2015-01-08	4	Hayden Michael R By Genworks Inc.	XENE	Common Shares	M - Exercise	I		4.9800	5,144	26		5,144
2015-01-12	2015-01-08	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-5,041		0
2015-01-12	2015-01-08	4	TARNOW MICHAEL M	XENE	Common Shares	M - Exercise	D		4.9800	5,041	25		53,624
2015-01-09	2015-01-07	4	PATOU GARY	XENE	Stock Option (Right to Buy)	M - Exercise	D	4.98		-3,497		0
2015-01-09	2015-01-07	4	PATOU GARY	XENE	Common Shares	M - Exercise	D		4.9800	3,497	17		3,497
2015-01-07	2014-12-31	4	MX Associates, LLP	XENE	Common Shares	J - Other	D			-17,680			0
2015-01-07	2014-12-31	4	MX Associates, LLP	XENE	Common Shares	J - Other	D			-85,119			17,680
2015-01-07	2014-12-31	4	MX Associates, LLP	XENE	Common Shares	J - Other	D			-85,119			17,680
2015-01-07	2014-12-31	4	MX Associates, LLP	XENE	Common Shares	J - Other	D			-117,456			187,918
2015-01-07	2014-12-31	4	MX Associates, LLP	XENE	Common Shares	J - Other	D			-1,169,286			305,374
2014-11-25	2014-11-21	4	Bridger Gary	XENE	Stock Option (Right to Buy)	A - Award	D	12.65		5,144		5,144
2014-11-12	2014-11-09	4	HOLLER FRANK A	XENE	Series E Preferred Shares	C - Conversion	D			-2,737		0
2014-11-12	2014-11-09	4	HOLLER FRANK A	XENE	Series B Preferred Shares	C - Conversion	D			-4,988		0
2014-11-12	2014-11-09	4	HOLLER FRANK A By wife	XENE	Series A Preferred Shares	C - Conversion	I			-941		0
2014-11-12	2014-11-09	4	HOLLER FRANK A	XENE	Series A Preferred Shares	C - Conversion	D			-95,002		0
2014-11-12	2014-11-09	4	HOLLER FRANK A By wife	XENE	Common Shares	C - Conversion	I			941			1,184
2014-11-12	2014-11-09	4	HOLLER FRANK A	XENE	Common Shares	C - Conversion	D			2,737			173,618
2014-11-12	2014-11-09	4	HOLLER FRANK A	XENE	Common Shares	C - Conversion	D			4,988			170,881
2014-11-12	2014-11-09	4	HOLLER FRANK A	XENE	Common Shares	C - Conversion	D			95,002			165,893
2014-11-12	2014-11-09	4	Evans Johnston L By Invesco Capital Entities	XENE	Series E Preferred Shares	C - Conversion	I			-444,655		0
2014-11-12	2014-11-09	4	Evans Johnston L By Invesco Capital Entities	XENE	Common Shares	C - Conversion	I			444,655			444,655
2014-11-12	2014-11-09	4	Hayden Michael R By wife	XENE	Series E Preferred Shares	C - Conversion	I			-1,504		0
2014-11-12	2014-11-09	4	Hayden Michael R By wife	XENE	Series B Preferred Shares	C - Conversion	I			-2,693		0
2014-11-12	2014-11-09	4	Hayden Michael R By wife	XENE	Series A Preferred Shares	C - Conversion	I			-10,030		0
2014-11-12	2014-11-09	4	Hayden Michael R By wife	XENE	Common Shares	C - Conversion	I			1,504			75,886
2014-11-12	2014-11-09	4	Hayden Michael R By wife	XENE	Common Shares	C - Conversion	I			2,693			74,382
2014-11-12	2014-11-09	4	Hayden Michael R By wife	XENE	Common Shares	C - Conversion	I			10,030			71,689
2014-11-12	2014-11-09	4	TARNOW MICHAEL M	XENE	Series A Preferred Shares	C - Conversion	D			-16,718		0
2014-11-12	2014-11-09	4	TARNOW MICHAEL M	XENE	Common Shares	C - Conversion	D			16,718			48,583
2014-11-12	2014-11-09	4	PIMSTONE SIMON N.	XENE	Series B Preferred Shares	C - Conversion	D			-1,914		0
2014-11-12	2014-11-09	4	PIMSTONE SIMON N.	XENE	Series A Preferred Shares	C - Conversion	D			-964		0
2014-11-12	2014-11-09	4	PIMSTONE SIMON N.	XENE	Common Shares	C - Conversion	D			1,914			192,307
2014-11-12	2014-11-09	4	PIMSTONE SIMON N.	XENE	Common Shares	C - Conversion	D			964			190,393
2014-11-12	2014-11-09	4	STEIN EVAN A. By Lipoterx, Ltd.	XENE	Series E Preferred Shares	C - Conversion	I			-1,038,964		0
2014-11-12	2014-11-09	4	STEIN EVAN A. By Stein Family LLC	XENE	Series B Preferred Shares	C - Conversion	I			-967		0
2014-11-12	2014-11-09	4	STEIN EVAN A. By Lipoterx, Ltd.	XENE	Common Shares	C - Conversion	I			1,038,964			1,038,964
2014-11-12	2014-11-09	4	STEIN EVAN A. By Stein Family LLC	XENE	Common Shares	C - Conversion	I			967			967
2014-11-12	2014-11-09	4	MX Associates, LLP	XENE	Series E Preferred Shares	C - Conversion	D			-1,474,660		0
2014-11-12	2014-11-09	4	MX Associates, LLP	XENE	Common Shares	C - Conversion	D			1,474,660			1,474,660
2014-11-06		3/A	HOLLER FRANK A By wife	XENE	Common Shares		I						243
2014-11-06		3/A	HOLLER FRANK A	XENE	Common Shares		D						70,891
2014-11-06	2014-11-04	4	TARNOW MICHAEL M	XENE	Stock Option (Right to Buy)	A - Award	D	9.00		5,144		5,144
2014-11-06	2014-11-04	4	Hayden Michael R	XENE	Stock Option (Right to Buy)	A - Award	D	9.00		5,144		5,144
2014-11-06	2014-11-04	4	AZAB MOHAMMAD	XENE	Stock Option (Right to Buy)	A - Award	D	9.00		5,144		5,144
2014-11-06	2014-11-04	4	Evans Johnston L	XENE	Stock Option (Right to Buy)	A - Award	D	9.00		5,144		5,144
2014-11-06	2014-11-04	4	PATOU GARY	XENE	Stock Option (Right to Buy)	A - Award	D	9.00		5,144		5,144
2014-11-06	2014-11-04	4	STEIN EVAN A.	XENE	Stock Option (Right to Buy	A - Award	D	9.00		5,144		5,144
2014-11-06	2014-11-04	4	HOLLER FRANK A	XENE	Stock Option (Right to Buy)	A - Award	D	9.00		5,144		5,144
2014-11-04		3	CORRAINI KAREN G.	XENE	Common Shares		D						4,114
2014-11-04		3	CORRAINI KAREN G.	XENE	Common Shares		D						4,114
2014-11-04		3	Hayden Michael R	XENE	Common Shares		D						256,297
2014-11-04		3	Hayden Michael R By wife	XENE	Common Shares		I						220,637
2014-11-04		3	Hayden Michael R	XENE	Common Shares		D						256,297
2014-11-04		3	Hayden Michael R By wife	XENE	Common Shares		I						220,637
2014-11-04		3	TARNOW MICHAEL M	XENE	Common Shares		D						63,730
2014-11-04		3	TARNOW MICHAEL M	XENE	Common Shares		D						63,730
2014-11-04		3	HOLLER FRANK A	XENE	Common Shares		D						142,025
2014-11-04		3	HOLLER FRANK A By wife	XENE	Common Stock		I						71,377
2014-11-04		3	HOLLER FRANK A	XENE	Common Shares		D						142,025
2014-11-04		3	HOLLER FRANK A By wife	XENE	Common Stock		I						71,377
2014-11-04		3	ROBIN SHERRINGTON	XENE	Common Shares		D						4,114
2014-11-04		3	ROBIN SHERRINGTON	XENE	Common Shares		D						4,114
2014-11-04		3	PIMSTONE SIMON N.	XENE	Common Shares		D						395,318
2014-11-04		3	PIMSTONE SIMON N.	XENE	Common Shares		D						395,318
2014-11-04		3	PIMSTONE SIMON N. By wife	XENE	Common Shares		I						222,349
2014-11-04		3	PIMSTONE SIMON N. By wife	XENE	Common Shares		I						222,349
2014-11-04		3	GOLDBERG Y. PAUL	XENE	Common Shares		D						8,640
2014-11-04		3	GOLDBERG Y. PAUL	XENE	Common Shares		D						8,640

Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.

Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.

Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)

Konversi turunan

Penjualan atau pengalihan sekuritas kembali ke perusahaan.

Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.

Pemberian sekuritas oleh atau kepada orang dalam.

Swap ekuitas dan transaksi lindung nilai serupa

Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)

Transaksi yang dilaporkan secara sukarela pada Formulir 4.

Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)

XENE / Xenon Pharmaceuticals Inc. - Insider Trading and Ownership Report - SEC Form 3, 4, 5